24th week of 2014 patent applcation highlights part 49 |
Patent application number | Title | Published |
20140162276 | METHOD OF AMPLIFYING TARGET NUCLEIC ACID, METHOD OF ANALYZING TARGET NUCLEIC ACID, KIT FOR AMPLIFYING TARGET NUCLEIC ACID, AND COMPOSITION FOR AMPLIFYING TARGET NUCLEIC ACID - Provided are methods of efficiently amplifying or analyzing a target nucleic acid and a kit and a composition to efficiently amplify a target nucleic acid. | 2014-06-12 |
20140162277 | METHOD FOR PREDICTING RESPONSIVENESS TO DRUGS - The present invention provides a novel method to determine the likelihood of effectiveness of a treatment in an individual affected with or at risk for developing cancer. The method involves detecting the presence or absence of Met amplification in an individual. The presence of Met amplification indicates that a Met targeting treatment is likely to be effective. Preferably, the Met targeting treatment is PHA-665752 or PF-02341066. In addition, the present methods allow for the detection of cancer in an individual, wherein the presence of Met amplification indicates that cancer is present and further that it will be treatable, namely with a Met targeting treatment. | 2014-06-12 |
20140162278 | METHODS AND COMPOSITIONS FOR ENRICHMENT OF TARGET POLYNUCLEOTIDES - The invention provides methods, apparatuses, and compositions for high-throughput amplification sequencing of specific target sequences in one or more samples. In some aspects, barcode-tagged polynucleotides are sequenced simultaneously and sample sources are identified on the basis of barcode sequences. In some aspects, sequencing data are used to determine one or more genotypes at one or more loci comprising a causal genetic variant. | 2014-06-12 |
20140162279 | PROCESS FOR IMPROVED PROTEIN EXPRESSION BY STRAIN ENGINEERING - This invention is a process for improving the production levels of recombinant proteins or peptides or improving the level of active recombinant proteins or peptides expressed in host cells. The invention is a process of comparing two genetic profiles of a cell that expresses a recombinant protein and modifying the cell to change the expression of a gene product that is upregulated in response to the recombinant protein expression. The process can improve protein production or can improve protein quality, for example, by increasing solubility of a recombinant protein. | 2014-06-12 |
20140162280 | METHODS AND SYSTEM FOR THE AUTOMATED DETERMINATION OF IMMUNOFLUORESCENT FOCI USING A CELL-BASED IMMUNOFLUORESCENCE ASSAY USING SYNTHETIC CALIBRATION PARTICLES - The invention relates to a method for automated determination of immunofluorescent foci by means of an immunofluorescence assay using synthetic calibration particles, in addition to a system and kit for carrying out the method. In a preferred embodiment the method is characterized in that the immunofluorescent foci are gamma H2Ax foci. | 2014-06-12 |
20140162281 | COMPOSITIONS AND KITS FOR SEPARATING CELLS AND METHOD OF SEPARATING CELLS USING THE SAME - Provided are compositions, kits, and methods for separating cells including complexes of at least one type of linker capable of binding to an antibody or antigen binding fragment and a solid phase. | 2014-06-12 |
20140162282 | METHODS FOR DETERMINING DRUG EFFICACY USING CEREBLON-ASSOCIATED PROTEINS - Use of cereblon-associated proteins as biomarkers for clinical sensitivity to cancer, inflammatory diseases, and patient response to drug treatment. | 2014-06-12 |
20140162283 | Compositions and Methods for Detecting Mycobacterium - The present disclosure provides methods of detecting | 2014-06-12 |
20140162284 | In Vitro Assay Method Using Immunological Technique - The present invention relates to a novel method of in vitro assay of the molecules of the extracellular matrix synthesized by cells in culture and uses thereof in the form of a kit for in vitro measurement and/or for a method of screening of cosmetic and/or pharmaceutical ingredients. | 2014-06-12 |
20140162285 | Methods of Modulating Vesicular Trafficking - Described are methods of identifying compounds useful for modulating vesicular trafficking, particularly those that disrupt the interactions between ARNO and the V-ATPase a2-subunit. Also described are peptides that modulate vesicular trafficking. | 2014-06-12 |
20140162286 | METHOD FOR THE DETECTION OF ENZYMATIC ACTIVITY WITH MAGNETICALLY FUNCTIONALIZED SUBSTRATES - The present invention provides methods for detecting an enzymatic activity, the method including combining at least one magnetic particle to an enzyme substrate to form a magnetically modified substrate, reacting the magnetically modified substrate with at least one enzyme; and detecting a change in a magnetic property of the magnetically modified substrate or its cleavage products, thereby detecting an activity of said at least one enzyme, wherein the method may be applied to a human subject to detect a disease selected from the group consisting of rheumatitis, arthritis, an injury, Dupuytren's disease, Peyronie's disease, a collagen related disease, steatosis, fibrosis, cirrhosis, metastasis, tissue regeneration, cancer, coronary disease, a liver disease, a metabolic condition, an infection and an inflammatory disease. | 2014-06-12 |
20140162287 | Method for Prognosing Response to Cancer Therapy with 5, 10, 15, 20-Tetrakis (Carboxyphenyl) Porphine - Presented is a method of prognosing a patient's response to a cancer therapy wherein prior to the therapy contacting a sample of cells from the patient's tissue or organ being treated for the cancer with a solution of TCPP to permit binding of the TCPP to components of the abnormal dysplastic or carcinomic cells, if any are present; detecting TCPP fluorescence in the sample, the presence of TCPP fluorescence being indicative that the sample contains dysplastic or carcinomic cells; at intervals during the therapy and subsequent to the therapy performing steps a-c on another sample of cells from the patient's tissue or organ being treated for the cancer; and determining if the percentage of abnormal pre-cancerous cells in the samples tested during and subsequent to the therapy are reduced as compared with the sample tested prior to the therapy, the reduction being prognostic of the patients response to the cancer therapy. | 2014-06-12 |
20140162288 | BIOMARKER FOR REPLICATIVE SENESCENCE - The present invention provides biomarkers for replicative senescence. In particular, Lamin B1 is provided as a biomarker for replicative senescence. | 2014-06-12 |
20140162289 | IDENTIFYING MOLECULES MODULATING PROTEIN-PROTEIN INTERACTIONS USING PROTEASE ACTIVATED REPORTERS - Assay methods and systems use enzymatic cleavage resulting from protein-protein interaction to modulate (activate or inactivate) a reporter. | 2014-06-12 |
20140162290 | PROBE FOR DETECTING DEAD CELL - Provided is a molecular imaging probe that accumulates specifically and highly sensitively at a tumor site in vivo, and enables quantitative analysis, e.g. a probe for detecting an apoptotic cell(s) and/or a necrotic cell(s), comprising a fusion protein of a Tim4 protein and a protein or polypeptide that forms a dimer, the protein or polypeptide being bound to the C-terminus of the Tim4 protein, wherein the mucin domain of the Tim4 protein and the C-terminal side domain thereof are replaced with a polypeptide consisting of the amino acid sequence of a) or b) below: a) an amino acid sequence having a length of 30 to 120 amino acid residues comprised in the amino acid sequence of the mucin domain of a wild-type Tim4 protein; b) an amino acid sequence having an identity of not less than 80% to the amino acid sequence of a). | 2014-06-12 |
20140162291 | IN VITRO METHOD USING HUMAN SKIN FOR EVALUATING THE INFLUENCE OF ABC TRANSPORTERS - An in vitro method is described that uses full-thickness human skin for evaluating the influence of ABC transporters (such as MDR1, MRP1, MRP2 or BCRP) on the absorption and distribution of topically applied medicinal substances. | 2014-06-12 |
20140162292 | Reagent For Diagnosing Tumor, Pharmaceutical Composition, And Screening Method - The present invention provides antibodies useful for diagnosing and treating tumors as well as methods of screening for antitumor agents. More specifically, tumors can be diagnosed and treated using an anti-phosphorylated p62 antibody that recognizes phosphorylation of serine at position 351 of an amino acid sequence of SEQ ID No. 1 or at a position corresponding thereto. An antitumor agent can be obtained by screening for a substance that inhibits the phosphorylation or that dephosphorylates the phosphorylated serine. | 2014-06-12 |
20140162293 | GENE CODED FOR A MHC CLASS I MOLECULE, PLASMID, EXPRESSION SYSTEM PROTEIN, MULTIMER, REAGENT AND KIT TO ANALYZE A T CELL FREQUENCY - A gene coded for a MHC class I molecule. The MHC class I molecule comprises an ALPHA-1 helix and an ALPHA-2 helix. The gene is coded so that a bond is formed between the ALPHA-1 helix and the ALPHA-2 helix in the MHC class I molecule. | 2014-06-12 |
20140162294 | METHODS AND COMPOSITIONS FOR ASSAYING VITAMIN D - The present invention provides methods for assaying a vitamin D moiety in a sample, using a water miscible organic solvent, a specific binding partner that specifically binds to said vitamin D moiety, the binding partner being different from a natural vitamin D binding protein for the vitamin D moiety, and a water soluble polymer that facilitates binding between the specific binding partner and the vitamin D moiety. Kits and reaction mixtures for assaying a vitamin D moiety in a sample are also provided. | 2014-06-12 |
20140162295 | Method and Biomarker for Detecting of Acute Kidney Injury - A method and a biomarker for detecting of acute kidney injury is provided, wherein the method of the present comprises the following steps: detecting a soluble form of hemojuvelin in a sample obtained from a subject, wherein when the soluble form of hemojuvelin is present in the sample, the subject is identified as having acute kidney injury. | 2014-06-12 |
20140162296 | Novel Read-Through Fusion Polynucleotides and Polypeptides and Uses Thereof - The present disclosure provides for and relates to novel fusion proteins and polypeptides expressed by breast cancer and other cancer cells, and to compositions, materials and methods for detecting, characterizing and treating said breast and other cancers. In one embodiment, the fusion polypeptides are read-through fusion transcripts. | 2014-06-12 |
20140162297 | ANTI-CARBAMYLATED PROTEIN ANTIBODIES AND THE RISK FOR ARTHRITIS - Antibodies against citrullinated protein antigens (ACPA) have shown their relevance for the diagnosis and possibly pathogenesis in arthritis. Described are means and methods for determining antibodies against homocitrulline-containing proteins or carbamylated proteins/peptides (anti-CarP) for the classification of individuals suffering from, or at risk of suffering from, arthritis. | 2014-06-12 |
20140162298 | IMMOBILIZED ENZYMATIC REACTOR - An immobilized enzymatic reactor can include a wall defining a chamber having an inlet and an outlet; a solid stationary phase covalently linked to an enzyme and disposed within the chamber; and a pressure modulator in fluid communication with the chamber and adapted to support continuous flow of a liquid sample comprising a polymer analyte through the inlet, over the solid stationary phase, and out of the outlet under a pressure between about 2,500 and 35,000 psi. In one example, the solid stationary phase includes inorganic/organic hybrid particles in an ultra performance liquid chromatography system, the enzyme is a protease, and the polymer analyte is a polypeptide. The immobilized enzymatic reactor can prepare an analyte for applications such as for hydrogen deuterium exchange mass spectrometry. | 2014-06-12 |
20140162299 | RAPID AND ACCURATE ANALYSIS OF PROTEIN SIALYLATION - The invention relates to methods and kits for the analysis of the sialylation of gluco-proteins. The samples of gluco-protein are incubated separately under three conditions: with beta-galactosidase, with beta-galactosidase+alpha-sialidase, and without an enzyme. After the enzyme treatment, high performance anion exchange chromatography with pulsed amperometric detection (HPAEC PAD) is used to make a quantitative determination of the total galactose in the sample, the non sialylated galactose and the exogenous galactose in the medium. The determination of said values makes it possible to deduce the percentage of sialylation of the gluco-protein. | 2014-06-12 |
20140162300 | SPHINGOMYELIN MEASUREMENT METHOD AND MEASUREMENT KIT - Provided is a method for simply and accurately measuring sphingomyelin in a sample, and a kit therefor. The method is a method for measuring sphingomyelin in a sample, comprising reacting the sample with a phospholipase D which does not react with sphingomyelin and lysophosphatidylcholine but reacts with phosphatidylcholine, a lysophospholipase or a monoglyceride lipase, and a choline oxidase, eliminating the formed hydrogen peroxide, reacting the resultant with a phospholipase D which does not react with glycerol-3-phosphorylcholine and free fatty acid but reacts with sphingomyelin, and a choline oxidase, and measuring the formed hydrogen peroxide. | 2014-06-12 |
20140162301 | Method for Classifying the Presence or Absence of a Microorganism in a Biological Medium - The present invention relates to a method for determining the presence or absence of a microorganism, said method including the steps of: 1) providing an enclosure containing a liquid or semi-solid phase consisting of a biological medium capable of containing a living form of said microorganism, nutritional elements, and an enzymatic substrate which is specific to said microorganism and which can be metabolised into at least one VOC metabolite, and a gaseous phase adjacent to said liquid or semi-solid phase; 2) exposing at least said liquid or semi-solid phase to conditions that are propitious for said microorganism to metabolise said enzymatic substrate into a molecule of said VOC metabolite; and 3) determining, by optical transduction, the presence or absence of said VOC metabolite, characterised in that the latter interacts with a nanoporous matrix, said matrix being implemented in a form that is separate from said enzymatic substrate, and in that the detection, by optical transduction, of a change in the optical properties of said matrix indicates an interaction of said matrix with said metabolite. | 2014-06-12 |
20140162302 | PON1 AS A MARKER FOR HEART FAILURE - Provided herein are methods for assessing the risk a test subject with heart failure has of experiencing a major adverse cardiac event, requiring revascularization, requiring a heart transplant, requiring unscheduled hospitalization for heart failure, progression of heart failure status, or any combination thereof. Also provided herein are methods for assessing the risk a test subject has of developing heart failure. The present methods comprise determining the levels of paraoxonase 1 activity in the serum, non-chelated plasma, or both in the test subject and comparing the level of PON1 activity in the test subject's sample with a control or baseline value based on levels of PON1 activity in serum, non-chelated plasma, or both samples from a population of control subjects. Also provided herein are kits useful in assessing such risks. | 2014-06-12 |
20140162303 | Method for marking or immobilising a target structure - Method for marking a target structure, comprising the following steps:
| 2014-06-12 |
20140162304 | MACROPHAGE HAZARDOUS MATERIAL DETECTION - Sentinel Cells, respond quickly and differentially to and among various high explosives (e.g., RDX, PETN, HMX, TNT, TNG), taggant (DMDNB), and bacteria, as well as volatiles of commercial C4, Semtex 1A, and military C4. These effects are observable within 5 minutes of exposure, indicate profound biological effects in exposed cells, and are distinctly different from responses to bacteria (e.g., | 2014-06-12 |
20140162305 | Patient In Vivo Gut Diagnostic and Treatment Tool - An orally ingestible capsule device with monitoring and control instruments is provided for practicing physicians to use in patient examining rooms. The Capsule is part of an in vivo gut healthcare system with capabilities of delivering medications to any point in the gut, administering them at any time, or autonomously based upon onboard measurements, and simultaneously measuring results, along with extra body function measurements. It is capable of delivering gut medications or autoimmune perturbation substances and simultaneously measuring responses and sample gut substances/microbes at application points. Objectives, as part of patient diagnosis, include determining microbe roles in the patient's digestion process, along with toxic substances contributing to illnesses or diseases, such as gluten sensitivities. Capsule embodiments include a belt with pockets for substance delivery or sampling, lab-on-a-chip devices, chip-based logic, sensor/transducer, and control circuits, and data reduction and storage, for efficient, cost-effective diagnostics and treatment in minimal time. | 2014-06-12 |
20140162306 | POLYMUTANT TAU PROTEIN VARIANTS AND THEIR USE FOR RECAPITULATING HUMAN TAUOPATHIES - The present invention relates to a tau protein comprising at least four different mutations selected from group consisting of mutations which cause the condition frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), and to nucleic acids encoding said tau protein. The invention further pertains to methods for identifying an agent for treating or preventing neurogenerative disease, and to methods for recapitulating tauopathies. | 2014-06-12 |
20140162307 | METHODS FOR MAKING A STERILIZATION INDICATOR AND FOR MONITORING A STERILIZATION PROCESS USING MEMBRANE POTENTIAL - The disclosed invention relates to a method of making a sterilization indicator including depositing an electronically conductive material on a substrate using an ink jet printer and depositing a biological indicator on part or all of the electronically conductive material using the ink jet printer, and further relates to a method for monitoring a sterilization process including (A) exposing an article to be sterilized and a biological indicator to a sterilization medium during a sterilization process, the biological indicator comprising a cell with a plasma membrane in which the biological indicator is positioned on part or all of an electronically conductive material positioned on a substrate; and (B) measuring the membrane potential of the cell to detect the viability of the cell. | 2014-06-12 |
20140162308 | DEVICE AND METHOD FOR IDENTIFYING MICROBES AND COUNTING MICROBES AND DETERMINING ANTIMICROBIAL SENSITIVITY - A method of determining antimicrobial activity of an agent can include providing a well, wherein the well contains at least one antimicrobial agent, the well further including at least two electrodes. A sample of a microbe can be added into the well and a voltage pulsed between the electrodes. An electrical property can be sampled and recorded. In another aspect, a method of identifying at least one microbe includes taking a sample containing the at least one microbe, isolating the at least one microbe from the sample, dividing the at least one microbe into at least one well, wherein each well contains at least one antimicrobial agent and at least two electrodes. A voltage is pulsed between the at least two electrodes, an electrical property is sampled during the pulsing and recorded. In another aspect, a diagnostic device for detecting at least one microbe is presented. | 2014-06-12 |
20140162309 | Arsenical Fluorescent Agents and Assays - The invention provides methods and compositions for labeling dithiol-containing analytes, including a substituted, optionally hydro-, optionally hetero-, monoarsenical anthracene compound comprising a 4′ rotation blocking group and a 5′ arsenic, and that exhibits a detectable increase or shift in fluorescence when the arsenic reacts with two thiols of a rotation-blocking binding target molecule. | 2014-06-12 |
20140162310 | RAPID DETECTION OF VIABLE BACTERIA SYSTEM AND METHOD - An improved system and method is provided for detecting viable bacteria in a suspension sample. A sample of a suspension in which bacterial presence is suspected is collected from a source and a portion of the sample transferred to a microfluidic unit. A series of analysis signals at different frequencies are applied to the sample portion. An impedance is measured via a signal analyzer for the sample portion for each of the analysis signals to define an impedance data set. An initial bulk capacitance value is determined for a model circuit based on the impedance dataset. After a predetermined time period, a new bulk capacitance value is determined for on another portion of the sample. The difference between the new bulk capacitance and the initial bulk capacitance value is compared to a threshold value to determine if viable bacterial is present in the sample. | 2014-06-12 |
20140162311 | CYTOBLOCK PREPARATION SYSTEM AND METHODS OF USE - An apparatus and method that may be used for collecting target cells or tissue and preparing a cell block are disclosed. | 2014-06-12 |
20140162312 | PENTOSE SUGAR FERMENTING CELL - The invention relates to a cell which comprises a nucleotide sequence encoding a xylose isomerase, wherein the amino acid sequence of the xylose isomerase has at least 75% sequence identity to the amino acid sequence set out in SEQ ID NO: 2 and wherein the nucleotide sequence is heterologous to the host. A cell of the invention may be used in a process for producing a fermentation product, such as ethanol. Such a process may comprise fermenting a medium containing a source of xylose with a cell of the invention such that the cell ferments xylose to the fermentation product. | 2014-06-12 |
20140162313 | METHOD FOR PREPARATIVE IN VITRO PROTEIN BIOSYNTHESIS - The invention relates to a method for preparative in vitro protein synthesis in a cell-free transcription/translation system, comprising the following steps: a) in a reaction vessel, a reaction solution is prepared, comprising the following synthesis substances: components of the transcription/translation apparatus for a defined-protein, amino acids, and metabolic components supplying energy and being necessary for the synthesis of the defined protein, b) the synthesis is performed in the reaction vessel in a defined period of time, c) after expiration of the defined period of time, the reaction solution is subjected to a separation step, in which generated low-molecular metabolic products are separated from the solution (and extracted). | 2014-06-12 |
20140162314 | High-Yield Peptide Antibiotics Producing Strain, Preparation Method and Use Thereof - High-yield antibiotics producing strain, preparation method and use thereof are provided in the present invention. The high-yield strain is a mutagenized strain derived from | 2014-06-12 |
20140162315 | Methylotrophic Yeast Transformed with Gal Promoters - A recombinant yeast of the genus | 2014-06-12 |
20140162316 | Anti-GLP-1R Antibodies and Their Uses - The present invention relates to antibodies reactive with GLP-1R, and methods of making and using them. | 2014-06-12 |
20140162317 | ISOFORM ENTRICHED ANTIBODY PREPARATION AND METHOD FOR OBTAINING IT - Herein is reported a method for producing an antibody preparation comprising the steps of a) applying a buffered solution comprising different isoforms of an antibody to a cation exchange chromatography material, b) applying a first solution with a first conductivity to the cation exchange chromatography material, whereby the antibody isoforms remain bound to the cation exchange chromatography material, and c) applying a second solution with a second conductivity to the cation exchange chromatography material and thereby obtaining the antibody preparation, whereby the conductivity of the second solution exceeds the conductivity of the first solution by not more than 10%. | 2014-06-12 |
20140162318 | ENHANCING INGREDIENTS FOR PROTEIN PRODUCTION FROM VARIOUS CELLS - [Summary] The present invention relates to a protein production accelerating agent that has enabled to largely increase the produced amount of a desired protein by adding polysaccharides to a medium for animal cells containing a serum or serum alternative, and a production method of a protein using a medium containing the protein production accelerating agent. | 2014-06-12 |
20140162319 | NUCLEOTIDE SEQUENCES, METHODS, KIT AND A RECOMBINANT CELL THEREOF - The present disclosure relates to recombinant adeno-associated virus (AAV) vector serotype, wherein the capsid protein of AAV serotypes is mutated at single or multiple sites. The disclosure further relates to an improved transduction efficiency of these mutant AAV serotypes. The AAV serotypes disclosed are AAV1, AAV2, AAV3, AAV4, AAV5, AAV6, AAV7, AAV8, AAV9, AAV10. The instant disclosure relates to nucleotide sequences, recombinant vector, methods and kit thereof. | 2014-06-12 |
20140162320 | VECTOR FOR FOREIGN GENE INTRODUCTION, AND METHOD FOR PRODUCING VECTOR IN WHICH FOREIGN GENE HAS BEEN INTRODUCED - The purpose of the invention is to provide means with which it is possible to efficiently select a vector to which a foreign gene has been introduced when a foreign gene is to be introduced by homologous recombination to a vector having multiple sequences homologous with one another. The vector comprises, in succession, a replication origin, a sequence A, a marker gene X, two sequences C and D for introducing a foreign gene by homologous recombination, and a sequence B homologous with sequence A. The two sequences C and D are directly or indirectly adjacent to one another. The vector is used for introducing a foreign gene between the two adjacent sequences C and D. | 2014-06-12 |
20140162321 | Preparation of Gene-Specific Templates for the Use in Single Primer Amplification - This disclosure relates to methods for creating engineered templates that are useful for amplification of one or more antibody genes without the use of gene-specific primers. More specifically, templates engineered using these methods in a polymerase chain reaction setting which allows for the specific amplification of one or more antibody genes. | 2014-06-12 |
20140162322 | BIOLOGICAL PRODUCTION OF PENTOSE SUGARS USING RECOMBINANT CELLS - The invention provides, inter alia, compositions and methods for the biological production of pentose sugars, such as 2-methylerythritol (2-ME), 1-deoxyxylulose (1-DX), and monoacetylated-2-C-methylerythritols, using recombinant cells. | 2014-06-12 |
20140162323 | METHODS OF COMBINED BIOPROCESSING AND RELATED MICROORGANISMS, THERMOPHILIC AND/OR ACIDOPHILIC ENZYMES, AND NUCLEIC ACIDS ENCODING SAID ENZYMES - A genetically modified organism comprising: at least one nucleic acid sequence and/or at least one recombinant nucleic acid isolated from | 2014-06-12 |
20140162324 | Biorefinery Process for Extraction, Separation and Recovery of Fermentable Saccharides, Other Useful Compounds, and Yield of Improved Lignocellulosic Material from Plant Biomass - Non-food plant biomass is subjected hot-water extraction in a pressurized vessel at an elevated temperature up to about 250° C. without addition of reagents, to yield an aqueous extract containing hemicellulosic components and a lignocellulosic residue. The process leaves the lignocellulose substantially intact, but with the hemicellulosic content largely removed. The separated aqueous extract or liquor is concentrated and purified, and long-chain sugars are reduced into monomer saccharides. The lignocellulosic residue may be further processed, to yield a useful fibrous material that is highly resistant to sorption of water. This material may be used for composite materials that resist water degradation, or may be used to produce a higher thermal-yield, water-resistant fuel, or may be used as bioconversion feedstock for producing high-value, lignocellulosic derivatives. | 2014-06-12 |
20140162325 | Method for Producing an L-Amino Acid Using a Bacterium of the Family Enterobacteriaceae Having Enhanced Expression of the Flagella Formation and Motility Cascade Genes - The present invention provides a method for producing L-amino acid using a bacterium belonging to the family Enterobacteriaceae, particularly a motile bacterium belonging to the genus | 2014-06-12 |
20140162326 | METHODS FOR PREPARATION OF AMMONIUM SALTS OF C4 DIACIDS BY FERMENTAION AND INTEGRATED METHODS FOR MAKING C4 DERIVATIVES - Methods for forming ammonium salts of C4 diacids in a fermentation process with removal of divalent metal carbonate salts are disclosed. The pH of fermentation broths for production of C4 diacids is controlled by adding alkaline oxygen containing calcium or magnesium compounds, which forms divalent metal salts of the diacids. The divalent metal salts of the diacids are substituted with ammonium by introduction of ammonium salts at elevated temperature and pressure forming soluble ammonium salts thereof. C02 or bicarbonate is simultaneously added to the fennentation media at the elevated temperature and pressure. Reducing the temperature and pressure forms insoluble divalent metal carbonate salts that are separated from the solubilized ammonium diacid salts. | 2014-06-12 |
20140162327 | MICROORGANISMS AND METHODS FOR THE COPRODUCTION 1,4-BUTANEDIOL AND GAMMA-BUTYROLACTONE - The invention provides non-naturally occurring microbial organisms comprising 1,4-butanediol (14-BDO) and gamma-butyrolactone (GBL) pathways comprising at least one exogenous nucleic acid encoding a 14-BDO and GBL pathway enzyme expressed in a sufficient amount to produce 14-BDO and GBL. The invention additionally provides methods of using such microbial organisms to produce 14-BDO and GBL. | 2014-06-12 |
20140162328 | Efficient production of biofuels from cells carrying a metabolic-bypass gene cassette - A process for increasing the production of a glycolytic intermediate and/or an organic compound as defined herein by a cell that is able to express a nucleic acid molecule, wherein the expression of the nucleic acid molecule gives the cell the ability to increase the production of a glycolytic intermediate and/or the organic compound and wherein the carbon substrate is sugar and/or protein. | 2014-06-12 |
20140162329 | DGAT GENES COMPRISING PLECKSTRIN HOMOLOGY DOMAINS AND METHODS OF USE FOR TRIGLYCERIDE PRODUCTION IN RECOMBINANT MICROORGANISMS - The present invention provides novel diacylglycerol acyltransferase (DGAT) genes comprising Pleckstrin Homology (PH) domains. The present invention also provides for recombinant cells, such as algae, transformed with acyltransferase genes, such as DGAT, comprising PH domains, and methods of using such recombinant cells to produce increased triglyceride levels. | 2014-06-12 |
20140162330 | ENGINEERED MICROALGAE WITH ENHANCED LIPID PRODUCTION - Described herein are engineered microalgae that exhibit enhanced lipid production during exponential growth. Such engineered microalgae are useful, for example, for the production of biofuels. | 2014-06-12 |
20140162331 | AMPHIPATHIC PEPTIDE-LIPASE CONJUGATE HAVING ADVANCED LIPASE ACTIVITY AND USE THEREOF - Disclosed are an amphipathic peptide-lipase conjugate with enhanced lipase activity, a polynucleotide coding for the conjugate, an expression vector carrying the polynucleotide, a transformant anchoring the expression vector therein, a method for preparing the conjugate, a lipolysis method using the conjugate, and a method for producing biodiesel using the lipase. | 2014-06-12 |
20140162332 | METHOD FOR PRODUCING SCLAREOL - The present invention provides a method of producing sclareol, the method comprising contacting a particular polypeptide having a sclareol synthase activity with labdenediol diphosphate (LPP). In particular, the method may be carried out in vitro or in vivo to produce sclareol, a very useful compound in the fields of perfumery and flavoring. The present invention also provides the amino acid sequence of the polypeptide used in the method. A nucleic acid derived from | 2014-06-12 |
20140162333 | Enhanced Pyruvate to Acetolactate Conversion in Yeast - A high flux in conversion of pyruvate to acetolactate was achieved in yeast through expression of acetolactate synthase in the cytosol in conjunction with reduction in pyruvate decarboxylase activity. Additional manipulations to improve flux to acetolactate are reduced pyruvate dehydrogenase activity and reduced glycerol-3-phosphate dehydrogenase activity. Production of compounds having acetolactate as an upstream intermediate benefit from the increased conversion of pruvate to acetolactate in the described strains. | 2014-06-12 |
20140162334 | XYLOSE-FERMENTING MICROORGANISM - The object of the present invention is to provide a microorganism capable of maintaining its xylose fermentation ability over a long period of time. The present invention also provides a microorganism deficient in the function of expressing NAD kinase gene and/or FPS1 gene, a method for preparing the above microorganism and a method for producing ethanol using the above microorganism. | 2014-06-12 |
20140162335 | Recombinant Yeast Expressing AGT1 - The present invention relates to the identification of variants of the sugar transporter AGT1 that provide enhanced fermentation of oligosaccharides when recombinantly expressed in yeast. The invention further relates to polynucleotides encoding the variants, recombinant yeast cells expressing the variants, and use of the recombinant yeast cells to ferment oligosaccharides. | 2014-06-12 |
20140162336 | MICROORGANISM MEDIATED LIQUID FUELS - Herein disclosed is a method for producing liquid hydrocarbon product, the method comprising disintegrating a hydrocarbon source; pretreating the disintegrated hydrocarbon source; solubilizing the disintegrated hydrocarbon source to form a slurry comprising a reactant molecule of the hydrocarbon source; admixing a biochemical liquor into the slurry, wherein the biochemical liquor comprises at least one conversion enzyme configured to facilitate bond selective photo-fragmentation of said reactant molecule of the hydrocarbon source, to form liquid hydrocarbons via enzyme assisted bond selective photo-fragmentation, wherein said conversion enzyme comprises reactive sites configured to restrict said reactant molecule such that photo-fragmentation favorably targets a preselected internal bond of said reactant molecule; separating the liquid hydrocarbons from the slurry, wherein contaminants remain in the slurry; and enriching the liquid hydrocarbons to form a liquid hydrocarbon product. Various aspects of such method/process are also discussed. | 2014-06-12 |
20140162337 | ISOPRENE PRODUCTION USING THE DXP AND MVA PATHWAY - The invention provides for methods for producing isoprene from cultured cells using various components of the DXP pathway and MVA pathway, or components associated with the DXP pathway and MVA pathway, iron-sulfur cluster-interacting redox polypeptides, and isoprene synthase. The invention also provides compositions that include these cultured cells. | 2014-06-12 |
20140162338 | DEVICE AND METHOD FOR PRODUCING A COLD, HOMOGENEOUS PLASMA UNDER ATMOSPHERIC PRESSURE CONDITIONS - The invention relates to a special plasma source designated as a plasma intractor (PI) for producing a cold, homogeneous plasma under atmospheric pressure conditions, which plasma source can be used advantageously to excite and control reactive processes in flowing media. The device according to the invention is characterized in that the device comprises at least 6 elongated electrodes ( | 2014-06-12 |
20140162339 | Stabilized Compounds Having Secondary Structure Motifs - The present invention provides novel stabilized crosslinked compounds having secondary structure motifs, libraries of these novel compounds, and methods for the synthesis of these compounds libraries thereof. The synthesis of these novel stabilized compounds involves (1) synthesizing a peptide from a selected number of natural or non-natural amino acids, wherein said peptide comprises at least two moieties capable of undergoing reaction to promote carbon-carbon bond formation; and (2) contacting said peptide with a reagent to generate at least one crosslinker and to effect stabilization of a secondary structure motif. The present invention, in a preferred embodiment, provides stabilized p53 donor helical peptides. Additionally, the present invention provides methods for disrupting the p53/MDM2 binding interaction comprising (1) providing a crosslinked stabilized α-helical structure; and (2) contacting said crosslinked stabilized α-helical structure with MDM2. | 2014-06-12 |
20140162340 | SYNTHETIC HEPATITIS C GENOME AND METHODS OF MAKING AND USE - Synthetic representative HCV subtypes, including a 1a and 1b genome, dubbed Bole1a and Bole1b, are provided using an inventive method of Bayesian phylogenetic tree analysis, ancestral sequence reconstruction and covariance analysis. Bole1a branches centrally among 390 full-genome sequences used in its design, a carefully curated 143 sequence full-genome dataset, and separate genomic regions including an independent set of 214 E1E2 sequences from a Baltimore cohort. Bole1a is phylogenetically representative of widely circulating strains. Full genome non-synonymous diversity comparison and 9-mer peptide coverage analysis showed that Bole1a is able to provide more coverage (94% and 78% respectively) than any other sequence in the dataset including H77, a traditional reference sequence. Bole1a also provides unsurpassed epitope coverage when compared to all known T cell epitopes. | 2014-06-12 |
20140162341 | METHOD AND COMPOSITION FOR CRYSTALLIZING A GPCR - Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising, from N-terminus to C-terminus: a) a first portion of a family C G-protein coupled receptor (GPCR), wherein the first portion comprises the TM1, TM2 and TM3, regions of the GPCR; b) a stable, folded protein insertion; and c) a second portion of the GPCR, wherein the second portion comprises the TM4, TM5 TM6 and TM7 regions of the GPCR. | 2014-06-12 |
20140162342 | METHODS AND COMPOSITIONS FOR PRODUCTION OF VACCINA VIRUS - Certain embodiments are directed to viral production processes for the large scale production of vaccinia virus. | 2014-06-12 |
20140162343 | SPORULATION-DEFICIENT B. TEXASPORUS CELLS AND METHODS FOR EFFICIENT AND COST-EFFECTIVE INACTIVATION AND USE THEREOF - Novel strains and methods for their use are provided. Particularly, foods and other oral products or treatments containing sporulation-deficient | 2014-06-12 |
20140162344 | IN SITU EXPRESSION OF LIPASE FOR ENZYMATIC PRODUCTION OF ALCOHOL ESTERS DURING FERMENTATION - Disclosed herein are methods of producing alcohol esters during a fermentation by providing alcohol-producing microorganisms which further comprise an engineered polynucleotide encoding a polypeptide having lipase activity. | 2014-06-12 |
20140162345 | LIGNOCELLULOSE CONVERSION PROCESSES AND PRODUCTS - Processes for converting lignocellulose to feedstock and downstream products are disclosed. The processes may include acid treatment of lignocellulose to produce a fermentation feedstock. In various instances, the processes include recovery or recycling of acid, such as recovery of hydrochloric acid from concentrated and/or dilute streams. Downstream products may include acrylic acid-based products such as diapers, paper and paper-based products, ethanol, biofuels such as biodiesel and fuel additives, and detergents. | 2014-06-12 |
20140162346 | METHOD OF CONCURRENTLY FILTERING PARTICLES AND COLLECTING GASES - A system for concurrently filtering particles and collecting gases. Materials are be added (e.g., via coating the ceramic substrate, use of loose powder(s), or other means) to a HEPA filter (ceramic, metal, or otherwise) to collect gases (e.g., radioactive gases such as iodine). The gases could be radioactive, hazardous, or valuable gases. | 2014-06-12 |
20140162347 | BIDIRECTIONAL TRANSFER OF AN ALIQUOTE OF FLUID BETWEEN COMPARTMENTS - An apparatus adapted to extract an ingredient from a fluid sample by bidirectional transferring of an aliquot of fluid having magnetic particles therein, said apparatus comprising: an open compartment operable at a constant ambient pressure; a closed compartment having a closed pressure, and an upper zone containing an air pocket adapted to generate internal positive and negative pressure; an intermediate transferring-retaining compartment adapted to temporarily retain a fraction of said aliquot of fluid; a flow barrier member adapted to inhibit a flow of said aliquot of fluid when said closed pressure is substantially equal to said ambient pressure and to allow said flow of fluid when said closed pressure is substantially different from said ambient pressure, the pressure differential controllable by a thermo member; a capturing zone adapted to allow magnetic particles in the fluid to be attracted in response to a magnetic force applied. | 2014-06-12 |
20140162348 | ELECTRICAL MEASURING CONTAINER, ELECTRICAL MEASURING APPARATUS AND ELECTRICAL MEASURING METHOD - There is provided an electrical measuring container of a biological sample in a liquid phase, including at least a biological sample holding section configured to accommodate a biological sample in a liquid phase and made of a resin, and an electrical conductive section fixed to the biological sample holding section. In a state in which a portion of the electrical conductive section is buried in the biological sample holding section, the biological sample holding section and the electrical conductive section are integrally formed with each other. | 2014-06-12 |
20140162349 | QUANTITATIVE PHASE MEASUREMENT APPARATUS - Provided is a small-sized quantitative phase measurement apparatus. The quantitative phase measurement apparatus | 2014-06-12 |
20140162350 | Method of Manufacturing a Sample Chamber - The invention comprises a method of manufacturing a sample chamber, comprising the steps of: providing a first ( | 2014-06-12 |
20140162351 | CULTURING SHEET, CULTURING EQUIPMENT MATERIAL AND MANUFACTURING METHOD - An operating efficiency of an observer is considerably restricted since it is not known at which position a culturing cell is disposed among a great number of pieces of holes of a culturing sheet. The culturing sheet is configured by a partitioning wall, a hole isolated by the partitioning wall, a local culturing region formed with plural local culturing region pillars a height of which is lower than that of the partitioning wall at a portion of a bottom face, and identification mark pillars formed at an identification mark region which differs from the culturing region at the bottom face of the hole. An identification mark is prevented from being unable to be optically recognized by adhering a spheroid to the identification mark region by making a diameter and a height of the identification mark pillar smaller than a diameter and a height of the local culturing pillar. | 2014-06-12 |
20140162352 | Dual Use Petri Plate With Locking Feature - A dish structure includes: (a) a bottom container having an outer cylindrical wall and a diametric base interconnecting the outer cylindrical wall; (b) a lid having an inverted cylinder provided with a downwardly extending cylindrical wall, the lid being sized so that the downwardly extending cylindrical wall associates with the outer cylindrical wall of the bottom container; (c) a frictionally-engagable member integral with the surface of the downwardly extending cylindrical wall of the lid; (d) a frictionally engagable member integral with the surface of the wall of the bottom container; and (e) at least one of the bottom container and the lid being formed of flexibly deformable synthetic plastic material, which is thin enough to have the characteristics of being flexibly deformable. By such structure the lid and bottom container base may remain loosely assembled (unlocked), or by user manipulation be tightly assembled into a reversibly locked configuration. | 2014-06-12 |
20140162353 | FLUID SEGMENT SAMPLING DEVICE - A fluid segment sampling device and method wherein a housing includes an input port configured to receive a segment tube, an output port configured for a receptacle, a passageway between the input port and the output port, and a side port leading into the passageway. A blade unit is insertable in the side port to cut a segment tube inserted into the input port. | 2014-06-12 |
20140162354 | METHOD AND SYSTEM FOR USE OF TREATMENT LIQUIDS IN AN APPARATUS FOR STAINING OF TISSUE SPECIMENS ON MICROSCOPE SLIDES - A method and a system for use of treatment liquids in an apparatus for staining of tissue specimens on microscope slides, wherein the apparatus comprises a plurality of vessels ( | 2014-06-12 |
20140162355 | Formulations Containing and Kit for Using Adipose-Derived Stem Cells and Use Thereof - Methods and kits for producing cellular fractions enriched in adipose derived stem cells. Methods are provided where adipose tissue obtained from liposuction is enzymatically treated using a solution containing collagenase and divalent cations prior to the application of traditional methods of stromal-vascular fraction isolation. The enzymatic solutions may contain collagenase types I and II to a final concentration of about 0.001 mg/ml to 0.010 mg/ml. The divalent cations may be present as calcium, magnesium, and zinc chloride. The final concentration of calcium, magnesium, and zinc may range from about 0.001 to 0.1 micromolar; about 0.005 to 0.5 micromolar; and about 0.0015 to 0.15 micromolar, respectively. The enzymatic solutions may be generated using a kit where the collagenase and divalent components are held in separate containers until just prior to use. The cellular fractions isolated in this manner may be used in autologous fat grafts in therapeutic applications. | 2014-06-12 |
20140162356 | MONOCLONAL ANTIBODIES WITH ENHANCED ADCC FUNCTION - The invention concerns a method for obtaining and selecting monoclonal antibodies by an ADDC-type test, said antibodies capable of activating type III Fcy receptors and having a particular glycan structure. The inventive anti-D antibodies can be used for preventing Rhesus isoimmunisation in Rh negative persons, in particular for haemolytic disease in a new-born baby of for uses such as idiopathic thrombocytopenic pupura 9ITP) | 2014-06-12 |
20140162357 | METHODS FOR GENERATION OF ANTIBODIES - This invention generally relates to methods for the production of antibody producing cells and antibodies in protooncogene expressing animals. The invention also relates to methods for the efficient production of antibodies specific for antigens that are normally subject to immunological constraints such as self tolerance. The invention further relates to the production of antibody producing cells and antibodies without the need for the conventional fusing of antibody producing B cells with a myeloma fusion partner. | 2014-06-12 |
20140162358 | Endogenous and Non-Endogenous Versions of Human G Protein-Coupled Receptors - The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is unknown, and to mutated (non-endogenous) versions of the human. GPCRs for evidence of constitutive activity. | 2014-06-12 |
20140162359 | Differentiation of Human Embryonic Stem Cells into Pancreatic Endoderm - The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides methods to produce a population of pancreatic endoderm cells, wherein the initial seeding density of undifferentiated epluripotent cells is defined. | 2014-06-12 |
20140162360 | NEEDLE ARRAY ASSEMBLY AND METHOD FOR DELIVERING THERAPEUTIC AGENTS - A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment. | 2014-06-12 |
20140162361 | PYRIMIDINE CYCLOHEXYL GLUCOCORTICOID RECEPTOR MODULATORS - The present invention provides a class of pyrimidinedione cyclohexyl compounds and methods of using these compounds as glucocorticoid receptor modulators. | 2014-06-12 |
20140162362 | Non-Simian Cells for Growth of Porcine Reproductive and Respiratory Syndrome (PRRS) Virus - Disclosed are compositions and methods relating to growth of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) using non-simian cells. In a particular example, porcine alveolar macrophage cells are described as having a capability of supporting infectivity and reproduction by PRRSV. Cells and cell lines of the invention are disclosed in connection with applications relating to PRRS disease, including vaccine technologies. | 2014-06-12 |
20140162363 | METHOD OF CELL CULTURES AND DEVICE FOR IMPLEMENTING IT - The invention generally provides a cell culture vessel having at least one first zone and at least one second zone, wherein the first zone is a transfer zone for a culture medium which essentially contains no cells and the second zone is a cell culture zone. The invention further includes methods utilizing the cell culture vessel. | 2014-06-12 |
20140162364 | METHOD FOR PRODUCING A POROUS CALCIUM POLYPHOSPHATE STRUCTURE - A method for producing a porous calcium polyphosphate structure, which comprises the steps of mixing monocalcium phosphate (MCP) with silicic acid, and sintering the mixture at a predefined temperature or temperatures for a predefined time, after which the porous calcium polyphosphate is obtained. The method allows a porous biomaterial with a controllable porosity to be obtained, and which also has the ability to activate the platelets in a plasma rich in platelets and cause the release of growth factors from the platelets. | 2014-06-12 |
20140162365 | SIMULATION SYSTEM OF CARDIAC FUNCTION, SIMULATION METHOD OF CARDIAC FUNCTION, SIMULATION PROGRAM OF CARDIAC FUNCTION, AND COMPOSITE MATERIAL SHEET - A composite material sheet to support all or any part of the heart includes a lamina or a laminate of thin sheet made of a composite material which contains reinforcement fiber matrix. A value for the Young' modulus of the reinforcement fiber is as large as one hundred times or more of a value for the Young' modulus of the matrix. | 2014-06-12 |
20140162366 | GENERATION OF VASCULAR PROGENITOR CELLS - Provided herein are, inter alia, methods of generating vascular progenitor cells from primary cells without reprogramming the primary cell into a pluripotent stem cell. The vascular progenitors provided herein may be used to form endothelial cells or smooth muscle cells. Further provided are isolated mutlitpotent cells useful to form vascular progenitor cells. | 2014-06-12 |
20140162367 | BACTERIAL STRAINS, PLASMIDS, METHOD OF PRODUCING BACTERIAL STRAINS CAPABLE OF CHEMOLITHOTROPHIC ARSENITES OXIDATION AND USES THEREOF - The invention provides novel strains | 2014-06-12 |
20140162368 | Portable Nanoparticle Based Assay For Rapid Detection of Food Antioxidants (NanoCerac) - Methods and assay for the portable colorimetric detection of an antioxidant in a food sample. According to one aspect the method comprises the steps of providing a colorimetric reagent comprising a plurality of ceria nanoparticles immobilized to a support, contacting the colorimetric reagent with the food sample, and detecting an optical property of the colorimetric reagent, wherein a change in the optical property of the colorimetric reagent is associated with the presence of antioxidant in the food sample, and further wherein the change in the optical property of the colorimetric reagent is dependent upon the concentration of the antioxidant in said food sample. | 2014-06-12 |
20140162369 | METHOD FOR MEASURING HEMOGLOBINS - The present invention aims to provide a method of measuring hemoglobins which can measure hemoglobins in a short time at high accuracy. The present invention also aims to provide a method of measuring hemoglobin A1c, a method of simultaneously measuring hemoglobin A1c and hemoglobin F, a method of simultaneously measuring hemoglobin A1c and hemoglobin A2, and a method of simultaneously measuring hemoglobin A1c and abnormal hemoglobins, each utilizing the above-mentioned method of measuring hemoglobins by liquid chromatography. The present invention relates to a method of measuring hemoglobins by liquid chromatography. A column used in the method is filled with, as a column-packing material, cation-exchangeable particles including cross-linked polymer particles having a cation-exchange-group-containing polymer bonded to the surface of the cross-linked polymer particles, and the column shows a pressure value of 9.8×10 | 2014-06-12 |
20140162370 | URINE BIOMARKERS FOR NECROTIZING ENTEROCOLITIS AND SEPSIS - Aspects of the invention include methods, compositions, and kits for diagnosing Necrotizing Enterocolitis (NEC), for diagnosing sepsis, for providing a prognosis for a patient with NEC, and for predicting responsiveness of a patient with NEC to medical intervention. These methods find use in a number of applications, such as diagnosing and treating infants who are suspected of having NEC, intestinal perforation (IP), or sepsis. | 2014-06-12 |
20140162371 | METHODS FOR DETECTING VITAMIN D METABOLITES BY MASS SPECTROMETRY - Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay. | 2014-06-12 |
20140162372 | DEVICE FOR MEASURING ELECTROLYTE IONS USING OPTODES AND USES THEREOF - Provided is a device for measuring electrolyte ions that is capable of providing a uniform pH environment in the region of an optode, and a method of measuring electrolyte ion concentration using the device. | 2014-06-12 |
20140162373 | MICROCHIP AND LIQUID SENDING METHOD FOR MICROCHIP - A microchip capable of sending liquid in a micro flow channel to a predetermined place irrespective of the pressure difference and sending a mixture of two or more liquid masses to a predetermined place even if the channel structure is simple. The microchip comprises an intermediate reservoir portion provided in a micro flow channel and adapted for temporarily holding liquid sent through the micro flow channel. The microchip is characterized in that the intermediate reservoir portion has a side channel, the volume of the intermediate reservoir portion is smaller than the total volume of the liquid sent into the intermediate reservoir portion, the side channel is provided for communication of a micro flow channel on the upstream side of the intermediate reservoir portion with a micro flow channel on the downstream side thereof, and the cross-section area of the side channel is smaller than that of the micro flow channel. | 2014-06-12 |
20140162374 | METHOD FOR HOLDING MULTIPLE TYPES OF DIAGNOSTIC TEST CONSUMABLES IN A RANDOM ACCESS SINGLE CONTAINER - An immunodiagnostic test method includes holding a selection of immunological test elements or consumables in one or more containers attached to or positioned in the analyzer and providing random access to any test element therein. The container can hold multiple types of test elements in compartments or slots. Through sensing of a test element position in its slot, the detection mechanism of the invention provides for random access to multiple types of test elements in any sleeve and within a single sleeve, and provides efficient inventory control. The method increases the number of test element types that may be loaded onto an analyzer and maintains fast determination of inventory. | 2014-06-12 |
20140162375 | CARBON BASED BIOSENSORS AND PROCESSES OF MANUFACTURING THE SAME - Sensors, processes for manufacturing the sensors, and processes of detecting a target molecule with the sensor generally includes a substrate including a channel and first and second electrodes electrically connected to the channel, wherein the channel includes a monolayer of surface functionalized graphene or surface functionalized carbon nanotubes, wherein the surface functionalized graphene or surface functionalized carbon nanotubes include an imidazolidone compound. | 2014-06-12 |