24th week of 2009 patent applcation highlights part 47 |
Patent application number | Title | Published |
20090149478 | NOVEL COMBINATION ANTICANCER AGENTS - A cancer therapeutic agent according to the present invention comprises a combination of compound A described below, or a pharmaceutically acceptable salt thereof, and compound B described below, or a pharmaceutically acceptable salt thereof:
| 2009-06-11 |
20090149479 | DOSING REGIMEN - Methods and kits are provided enabling a twice daily dosing regimen that achieves daily patient blood levels of active pharmaceutical ingredient comparable to a dosing regimen requiring the same active ingredient to be administered three times a day. | 2009-06-11 |
20090149480 | METHODS OF USING PDE V INHIBITORS FOR THE TREATMENT OF CONGESTIVE HEART FAILURE - The uses of PDE V inhibitors in methods for the treatment of congestive heart failure and other physiological disorders, as a monotherapy and in combination with other active agents are disclosed. Such PDE V inhibitors include those having the formula (I), with the variables defined herein: | 2009-06-11 |
20090149481 | PHARMACEUTICAL COMPOSITION AND BEVERAGE COMPOSITION COMPRISING L-ARGININE - A pharmaceutical composition and a beverage composition comprising the following three components (A), (B) and (C): (A) L-arginine or a salt thereof; (B) caffeine or a salt thereof; and (C) at least one substance selected from the group consisting of vitamin C or a derivative thereof, vitamin E or a derivative thereof and folic acid or a derivative thereof. The compositions show an effect of L-arginine even at a low L-arginine content, and therefore can be suitably used for the prevention, amelioration and/or treatment of at least one disease selected from the group consisting of arteriosclerosis, angiectasia, hyperlipemia, climacteric disorder, diabetes, angina pectoris, hypertension, erectile dysfunction, thrombosis, immunodeficiency, dementia, gestosis, respiratory failure and hemorrhoid, in the form of a pharmaceutical preparation or a beverage. | 2009-06-11 |
20090149482 | STEREOCHEMICALLY DEFINED DIPEPTIDE ESTERS OF ANTIVIRAL AGENTS FOR ENHANCED OCULAR TREATMENT - Stereochemically defined dipeptide esters of nucleoside-analogous antiviral agents including acyclovir and ganciclovir are provided. Certain of these stereochemically defined dipeptide esters are found to have unexpectedly enhanced delivery to and uptake by ocular tissues, crossing the blood-ocular barrier more effectively than other stereochemically defined dipeptide esters. For example, (L-Val)-(D-Val)-acyclovir was found to be taken up more effectively into corneal tissue than were underivatized acyclovir, monoesters (L-Val)-acyclovir or (D-Val)-acyclovir, or diester (L-Val)-(L-Val)-acyclovir. | 2009-06-11 |
20090149483 | BICYCLIC PYRROLE DERIVATIVES - Compounds represented by the general formula (I), prodrugs thereof, or pharmaceutically acceptable salts of both are provided as compounds which have high DPP-IV inhibiting activity and are improved in safety, toxicity and so on: (I) | 2009-06-11 |
20090149484 | QUINAZOLIN-4-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - The invention relates to chemical compounds of the formula (I): or pharmaceutically acceptable salts thereof, which possess B-Raf inhibitory activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm-blooded animal such as man. | 2009-06-11 |
20090149485 | PYRIMIDINEDIONES AS TYROSINE KINASE INHIBITORS - The present invention relates to a compound of formula (I) | 2009-06-11 |
20090149486 | 4,5-DIPHENYL-PYRIMIDINYL-OXY OR -MERCAPTO SUBSTITUTED CARBOXYLIC ACIDS, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS - This invention relates to a compound of formula I, | 2009-06-11 |
20090149487 | 4,5-DIPHENYL-PYRIMIDINYLAMINO SUBSTITUTED CARBOXYLIC ACIDS, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS - This invention relates to a compound of formula I, | 2009-06-11 |
20090149488 | Tetrahydroprotoberberine Compounds, the Synthetic Method and the Use Thereof - The present invention relates to tetrahydroprotoberberines of the formula (I) and the physiologically acceptable salts thereof. The invention also relates to the use of the compounds of the formula (I) or pharmaceutically acceptable salts thereof for preparing a pharmaceutical composition for the treatment of a medical disorder susceptible to treatment with dopamine receptor ligand, such as schizophrenia. | 2009-06-11 |
20090149491 | CARBOCYCLIC OXIME HEPATITIS C VIRUS SERINE PROTEASE INHIBITORS - The present invention discloses compounds of formula I, II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: | 2009-06-11 |
20090149492 | 7,8-DIHYDRO-1,6-NAPHTHYRIDIN-5(6H)-ONES AND RELATED BICYCLIC COMPOUNDS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV AND METHODS - The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I. Additionally, the present application provides pharmaceutical compositions containing at least one compound according to Formula I and optionally at least one additional therapeutic agent. Finally, the present application provides methods for treating a patient suffering from an DPP4 modulated disease or disorder such as, for example, diabetes, by administration of a therapeutically effective dose of a compound according to Formula I. | 2009-06-11 |
20090149493 | INHIBITORS OF THE INTERACTION BETWEEN MDM2 AND P53 - The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, m, p, s, t, R | 2009-06-11 |
20090149494 | THERAPEUTIC USE OF IMIDAZO[1,2-a]PYRIDINE-2-CARBOXAMIDE DERIVATIVES - The present invention is related to the use of a compound of formula (I): | 2009-06-11 |
20090149495 | COMPOUNDS - The present invention relates to new mGluR1 and mGluR5 receptor subtype preferring ligands of formula (I) wherein X represents a group selected from CO, SO, SO | 2009-06-11 |
20090149496 | INHIBITORS OF THE TASK-1 AND TASK-3 ION CHANNEL - The invention relates to the use of Kv1.5 inhibitors for the therapy or prophylaxis of respiratory disorders, sleep-related respiratory disorders, central and obstructive sleep apneas, upper airway resistance syndrome, Cheyne-Stokes respiration, snoring, disrupted central respiratory drive, sudden child death, postoperative hypoxia and apnea, muscle-related respiratory disorders, respiratory disorders after long-term ventilation, respiratory disorders during adaptation in high mountains, acute and chronic lung disorders with hypoxia and hypercapnia, neurodegenerative disorders, dementia, Alzheimer's disease, Parkinson's disease, Huntington's disease, cancer disorders, breast cancer, lung cancer, colon cancer and prostate cancer. | 2009-06-11 |
20090149497 | POLYMORPHS OF FEXOFENADINE HYDROCHLORIDE - The present invention provides novel crystal forms of fexofenadine hydrochloride Forms V, VI and VIII through XV and processes for their preparation and preparation of amorphous form and other crystalline forms of fexofenadine hydrochloride. Forms XIV and XV are solvates of ethyl acetate, while Form IX is anhydrous, but can be crystallized as a solvate of MTBE or cyclohexane. The forms are useful for administration to humans and animals to alleviate symptoms caused by histamine. The present invention further provides pharmaceutical compositions of the new crystalline forms. | 2009-06-11 |
20090149498 | Pharmaceutical composition having prokinetic effect - The invention refers to the use of O-(3-piperidino-2-hydroxypropyl)nicotinic amidoxime or a pharmaceutically suitable acid addition salt thereof for the preparation of a pharmaceutical composition that restores and/or enhances the activity of the neuronal nitric oxide synthase enzyme. | 2009-06-11 |
20090149499 | POLYMORPHIC FORMS OF 3-(4-AMINO-1-OXO-1,3 DIHYDRO-ISOINDOL-2-YL)-PIPERIDINE-2,6-DIONE) - Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione are disclosed. Compositions comprising the polymorphic forms, methods of making the polymorphic forms and methods of their use are also disclosed. | 2009-06-11 |
20090149500 | POLYMORPHIC FORMS OF 3-(4-AMINO-1-OXO-1,3 DIHYDRO-ISOINDOL-2-YL)-PIPERIDINE-2,6-DIONE - Polymorphic forms of 3-(amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione are disclosed. Compositions comprising the polymorphic forms, methods of making the polymorphic forms and methods of their use are also disclosed. | 2009-06-11 |
20090149501 | NOVEL INDOLES ARE CANNABINOID RECEPTOR LIGANDS - The present invention provides novel compounds of Formula (I) | 2009-06-11 |
20090149502 | Optically active isomers of ketotifen and therapeutically active metabolites thereof - Racemic norketotifen, racemic 10-hydroxy-ketotifen, racemic 10-hydroxy-nor-ketotifen and optically active isomers of ketotifen, norketotifen, 10-hydroxy-ketotifen and 10-hydroxy-norketotifen were found to have antiallergic and anti-inflammatory effects while being devoid of the severe dose-limiting sedative side effects of Ketotifen. | 2009-06-11 |
20090149503 | NEW 5-ARYL PYRIDINES AS 11-BETA INHIBITORS FOR THE TREATMENT OF DIABETES - Compounds of formula (I): | 2009-06-11 |
20090149504 | Novel 5-Substituted Indole Derivatives As Dipeptidyl Peptidase IV (DPP-IV) Inhibitors - The present invention relates to 5-substituted indole derivatives of formula (I): having inhibitory potential of dipeptidyl peptidase IV (DPP IV) enzyme where x and R | 2009-06-11 |
20090149505 | Metabotropic Glutamate Receptor-Potentiating Isoindolones - Compounds of Formula I: | 2009-06-11 |
20090149506 | INSECTICIDAL COMPOSITIONS WITH IMPROVED EFFECT - The present invention relates to increasing the activity of crop protection compositions comprising anthranilic acid diamides through the addition of ammonium salts and/or phosphonium salts or through the addition of ammonium or phosphonium salts and penetrants, to the corresponding compositions, to processes for preparing them and to their use in crop protection. | 2009-06-11 |
20090149507 | METHOD FOR CUSTOMIZED DISPENSING OF VARIABLE DOSE DRUG COMBINATION PRODUCTS FOR INDIVIDUALIZING OF THERAPIES - The method set out herein involves identifying the concentration of each of two or more active therapeutics tailored to treat a particular patient's unique metabolism and one or more diseases, communicating that information to a producer who has multiple fixed or variable concentrations of each active available, where the producer then combines the individual concentrations of each active into single units such as a tablets or pills, and distributes those indirectly or directly to the patient. | 2009-06-11 |
20090149508 | Process for the preparation of substituted phenyl ether compounds - A novel process for the preparation of a compound of the formula (II), which is useful as intermediate compound for the preparation of thiazolidinedione derivatives, such as rosiglitazone, pioglitazone, troglitazone and ciglitazone, is disclosed. | 2009-06-11 |
20090149509 | NOVEL PYRROLIDINE BICYCLIC COMPOUNDS AND ITS DERIVATIVES, COMPOSITIONS AND METHODS OF USE - N-[1-oxo-(optionally 2-aza)-2-alkyl-3-(carboxyl or thiol or hydroxyaminocarbonyl or N-hydroxyformamido)-propyl]-(aryl or heteroaryl)-azacyclo | 2009-06-11 |
20090149510 | Compositions and methods for modulating a kinase cascade - The invention relates to compounds and methods for modulating one or more components of a kinase cascade. | 2009-06-11 |
20090149511 | Administration of an Inhibitor of HDAC and an mTOR Inhibitor - Methods of treating patients with an HDAC inhibitor and an mTOR inhibitor are provided. | 2009-06-11 |
20090149512 | Use of Ghrelin Antagonists to the Treatment of Certain CNS Diseases - Ghrelin antagonists can be used for the treatment of certain CNS disorders. For example, certain oxadiazoles, preferably such being ghrelin antagonists, can be used to treat obesity, e.g., drug-induced obesity. | 2009-06-11 |
20090149513 | Compositions of an Orally Active 1,2,4-Oxadiazole for Nonsense Mutation Suppression Therapy - The present invention relates to specific doses of and dosing regimens for using a 1,2,4-oxadiazole benzoic acid compound in treating or preventing diseases associated with nonsense mutations. In particular, the invention relates to specific doses and dosing regimens for the use of 3-[5-(2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid in mammals having diseases associated with nonsense mutations. | 2009-06-11 |
20090149514 | OXADIAZOLINE LIGANDS FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX - The present invention relates to methods to use non-steroidal ligands in nuclear receptor-based inducible gene expression system to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene. | 2009-06-11 |
20090149515 | Treatments for the control of schistosomiasis - A method for controlling schistosome parasites in a mammal comprising delivering an effective amount of an agent for silencing TGR activity in the parasites. | 2009-06-11 |
20090149516 | Synthesis of Epothilones, Intermediates Thereto, Analogues and Uses Thereof - The present invention provides compounds of formula (I): | 2009-06-11 |
20090149517 | NOVEL 2-SUBSTITUTED TIAZOLE-4-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND USE AS PHARMACEUTICALS - The present invention relates to 2-substituted thiazole-4-carboxamide derivatives of the formula (I), the use thereof as medicament for the treatment of various disorders, and processes for the preparation thereof | 2009-06-11 |
20090149518 | PHARMACEUTICAL FOR PROTECTION OF MOTOR NERVE IN PATIENT WITH AMYOTROPHIC LATERAL SCLEROSIS - The present invention relates to an agent for protecting a motor nerve of a patient with amyotrophic lateral sclerosis, which comprises a combination of (a) (2R)-2-propyloctanoic acid or a salt thereof and (b) a therapeutic agent for amyotrophic lateral sclerosis such as riluzole. An agent comprising a combination of (a) (2R)-2-propyloctanoic acid which is orally administered once a day in an amount per dose of about 1200 mg and (b) riluzole which is orally administered twice a day in an amount per dose of about 50 mg is useful for protecting a motor nerve in a patient(s) with amyotrophic lateral sclerosis. The agent can also suppress the respiratory disability associated with the progression of the disease condition and improve the survival rate of the patient(s). | 2009-06-11 |
20090149519 | PHENYLAMINO-BENZOXAZOLE SUBSTITUTED CARBOXYLIC ACIDS, METHOD FOR THEIR PRODUCTION AND USE THEREOF AS MEDICAMENTS - This invention relates to a compound of formula I, | 2009-06-11 |
20090149520 | OXAZOLIDINONES CONTAINING OXINDOLES AS ANTIBACTERIAL AGENTS - The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein X is C | 2009-06-11 |
20090149521 | DUAL-ACTING BENZOIMIDAZOLE ANTIHYPERTENSIVE AGENTS - The invention relates to compounds having the formula: | 2009-06-11 |
20090149522 | Method of preserving a customised composition - The invention concerns a process for producing a preserved customised consumer composition, preferably from a Vending machine, wherein a plurality of ingredient streams are mixed together in predefined relative amounts, characterised in that At least two streams consist of water and preservative only, at least two of which having different concentrations of preservative. The Invention permits the final preservative mix to be independently variable to the formation. | 2009-06-11 |
20090149523 | USE OF N-AMINOIMIDAZOLE CYTOPROTECTIVE COMPOUNDS FOR TREATING CELL DEATH AND/OR GSK-3 MEDIATED DISEASES - The present invention relates to the use of N-aminoimidazole or N-aminoimidazole-thione derivatives as cytoprotective compounds in vitro and in vivo and for the treatment or prevention of cell death mediated disorders and/or GSK-3 mediated disorders or processes. | 2009-06-11 |
20090149524 | N-(Phenylmethyl)-2-(1H-Pyrazol-4-yl) Acetamide Derivatives as P2X7 Antagonists for the Treatment of Pain, Inflammation and Neurodegeneration - The present invention relates to novel pyrazole derivatives of formula (I) which bind to the P2X7 receptor and are capable of interfering with the effects of ATP at the P2X7 receptor: | 2009-06-11 |
20090149525 | NOVEL DERIVATIVES OF PORPHYRIN, PARTICULARLY CHLORINS AND/OR BACTERIOCHLORINS, AND USES THEREOF IN PHOTODYNAMIC THERAPY - The invention relates to derivatives of porphyrin, particularly chlorins and/or bacteriochlorins, which can be used in photodynamic therapy. According to the formulas of the invention, X | 2009-06-11 |
20090149526 | Tetracyclic Indole Derivatives as Antiviral Agents - The present invention relates to tetracyclic indole derivatives of formula (I): wherein Ar, A, R | 2009-06-11 |
20090149527 | Apparatus and Method for Application of a Pharmaceutical to a Surface of an External Ear Canal for Treatment of Keratosis Obutrans - A packaged kit for treating keratosis obturans includes a plurality of ear needles having different shaped absorbent applicators on distal ends of the needles, a vial of a single dose of an otologic formulation of mitomycin-C, and a diluent carrier syringe containing sterilized water. The component parts of the kit are used together to reconstitute the contents of the vial with the water in the diluent carrier syringe. A selected one of the plurality of ear needles is then communicated with the syringe. The syringe and needle are then used to inject the reconstituted drug into the absorbent pad at the end of the needle, and the absorbent pad containing the drug is used to apply the drug to the surface of the external ear canal. | 2009-06-11 |
20090149528 | Cinnamic acid amides - The present invention relates to compounds, to processes for preparing them, to pharmaceutical compositions comprising them, and to their use in the therapy and/or prophylaxis in illnesses in people or animals, especially diseases of bacterial infection. | 2009-06-11 |
20090149529 | Antioxidant-Containing Food Composition For Use In Enhancing Antiviral Immunity In Companion Animals - The invention encompasses compositions for enhancing the ability of a companion animal to resist and/or overcome viral infections. The compositions of the invention include an amount of lipoic acid that is effective in enhancing the antiviral immunity of a companion animal. | 2009-06-11 |
20090149530 | Antiinfective Flavonol Compounds and Methods of Use Thereof - In one aspect of the invention, the antiinfective agents are flavonol compounds of the represented by formula I: | 2009-06-11 |
20090149531 | CHEMICAL COMPOSITION DERIVED FROM P-HYDROXYPHENYL PROPIONIC ACID FOR THE TREATMENT OF PSORIASIS - The present invention is a chemical composition including: | 2009-06-11 |
20090149532 | HERPESVIRUS-DERIVED THERAPEUTIC AGENT FOR PAIN - A therapeutic agent for treatment of herpes virus-derived pain which comprises (±)-[2-[4-(3-ethoxy-2-hydroxypropoxy)phenylcarbamoyl]ethyl]dimethylsulfonium p-toluenesulfonate represented by the formula (1) as an active ingredient. | 2009-06-11 |
20090149533 | NOVEL FENOFIBRATE FORMULATIONS AND RELATED METHODS OF TREATMENT - The invention provides novel omega-3 ester-based oil solutions of fenofibrate. These solutions are substantially free of any food effect, effective in small volumes, and readily bioavailable. Notably, because the solutions of the invention contain an omega-3 ester-based oil as the major ingredient, they not only provide an antihyperlipidemic effect due to the fenofibrate active ingredient, they also provide recommended daily dosages of omega-3 oils (i.e., approximately 1 gram of omega-3 oil per day), or a portion thereof. | 2009-06-11 |
20090149534 | Crystalline modifications of (1R,2R)-3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)-phenol - Crystalline modifications of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol, pharmaceutical compositions which contain these modifications, and the use thereof to treat pain or other conditions. | 2009-06-11 |
20090149536 | 4-OXO-(ISO)TRETINOIN FOR THE TOPICAL TREATMENT OF SEVERE DERMATOLOGICAL DISORDERS - A method for the treatment of dermatological disorders wherein such treatment includes at least one of inhibiting lipogenesis in the skin and reducing the size of sebaceous glands, said treatment comprising the topical administration of a compound selected from 4-oxo-tretinoin, 4-oxo-isotretinoin and mixtures thereof to a patient in need thereof. The method of the invention is particularly advantageous for the topical treatment of severe acne and seborrhoea. | 2009-06-11 |
20090149537 | Use of Bile Acid or Bile Salt Fatty Acid Conjugates - The present invention relates to the use of a bile acid or bile salt fatty acid conjugate of general formula II | 2009-06-11 |
20090149538 | Aspirin-Triggered Lipid Mediators - Aspirin triggered lipid mediators (ATLMs) are disclosed which are useful for the treatment of prevention of inflammation associated with various diseases, including ischemia. | 2009-06-11 |
20090149539 | PET FOOD COMPOSITIONS AND METHODS - Presently described are compositions and methods which utilize stearidonic acid (SDA). | 2009-06-11 |
20090149540 | Compositions and Methods for Attenuating Mitochondria-Mediated Cell Injury - The present invention relates to a S-nitrosated mitochondria-targeted thiol-based antioxidant prodrug and uses therefore for the prevention or treatment of diseases or conditions associated with mitochondrial dysfunction resulting from changes in the mitochondrial redox environment. When activated, prodrug of the present invention can specifically provide a NO* donor and a thiol-based antioxidant to mitochondria thereby decreasing the degree of mitochondrial dysfunction. | 2009-06-11 |
20090149541 | Method of delaying the onset of clinically definite multiple sclerosis - A method for delaying the onset of clinically definite multiple sclerosis in a patient at risk of developing clinically definite multiple sclerosis and retard long-term progression of multiple sclerosis and its symptoms, the method comprising periodically administering a pharmaceutical composition comprising a therapeutically effective amount of glatiramer acetate to the patient, thereby delaying onset of clinically definite multiple sclerosis in the patient and retarding long-term progression of multiple sclerosis and its symptoms. | 2009-06-11 |
20090149542 | COMPOUNDS AND COMPOSITIONS FOR TREATING NEURONAL DEATH OR NEUROLOGICAL DYSFUNCTION - The present invention relates to 2-hydroxy-alkylamino-benzoic acid derivatives and to a combination of cell necrosis inhibitor and lithium, process for the preparation of the derivatives or the combination, pharmaceutical formulation containing the derivatives or the combination, and use of the derivatives or the combination by either concomitant or sequential administration for improvement of treatment of neuronal death or neurological dysfunction. The derivatives and the combination of the present invention are useful for treating neurological diseases, such as amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), spinal muscular atrophy, Alzheimer's disease, Parkinson's disease, Huntington's disease, stroke, traumatic brain injury or spinal cord injury; and for treating ocular diseases such as glaucoma, diabetic retinopathy or macular degeneration. | 2009-06-11 |
20090149543 | SOLID PHARMACEUTICAL COMPOSITIONS COMPRISING LUMIRACOXIB - A method of treating a cyclooxygenase-2 dependent disorder or condition comprising administering 5-methyl-2-(2′-chloro-6′-fluoroanilino)phenylacetic acid in an amount effective to treat such a disorder or condition for about 24 hours, comprising administering orally once a day to a human in need of such treatment one or more immediate release pharmaceutical compositions comprising 5-methyl-2-(2′-chloro-6′-fluoroanilino)phenylacetic acid, and compositions suitable for use in such methods. | 2009-06-11 |
20090149544 | Alpha-aminoamide derivatives - This invention relates to novel alpha-aminoamide derivatives, their pharmaceutically acceptable salts, solvates, and hydrates thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an inhibitor of monoamine oxidase type B (MAO-B) and/or a sodium (Na | 2009-06-11 |
20090149545 | TREATMENT OF CORONAVIRUS INFECTION - A method for treating coronavirus infection by administering to a subject in need of the treatment an effective amount of one or more of the following compounds: aklavin, sanguinarine, amiodarone, chlorpromazine, clomiphene, dihydroergotamine, dipyridamole, emetine, ephedrine, prochlorperazine, promazine, propiomazine, aminacrine, fluphenazine, fenoterol, peruvoside, proglumide, atenolol, nerifolin, nefopam, cycloheximide, avermectin B1, bepridil, cinnarizine, ethisterone, pararosaniline, methylbenzethonium, niclosamide, pipobroman, homidium, calcimycin, anisomycin, metergoline, amodiaquine, danazol, danthron, ethopropazine, eucatropine, nortriptyline, resorcinol, mebhydrolin, mebeverine, trimipramine, triflupromazine, chlorprothixene, cyclobenzaprine, enoxacin, sulfanitran, monensin, nigericin, perphenazine, methoxamine, astemizole, trifluoperazine, acriflavinium, rotenone, acebutolol, quabain, methiothepin, convallatoxin, halcinonide, cyclosporin, pimethixene, mycophenolic acid, promethazine, mesoridazine, thioridazine, chlorprothixene, thiothixene, clozapine, haloperidol, haloperidol decanoate, loxapine, molindone, olanzapine, pimozide, quetiapine, risperidone, and amitriptyline. | 2009-06-11 |
20090149546 | Enhanced Bimatoprost Ophthalmic Solution - A composition comprising from 0.005% to 0.02% bimatoprost by weight and from 100 ppm to 250 ppm benzalkonium chloride, wherein said composition is an aqueous liquid which is formulated for ophthalmic administration is disclosed herein. | 2009-06-11 |
20090149547 | VIRUCIDAL DISINFECTANT FOR AVIAN INFLUENZA VIRUS - A novel virucidal disinfectant for avian influenza virus is provided. A virucidal disinfectant for avian influenza virus characterized by containing as essential constituents
| 2009-06-11 |
20090149548 | NOVEL 1,2-DIPHENYLETHENE DERIVATIVES FOR TREATMENT OF IMMUNE DISEASES - The invention provides novel 1,2-diphenylethene derivatives and pharmaceutically acceptable salts thereof, the process for production of these compounds and their pharmaceutical composition and the use of these compounds as modulators of T-cells, neutrophils, macrophages and their associated cytokines as agents for treating immune, inflammatory and auto-immune diseases. | 2009-06-11 |
20090149549 | PREPARATION OF CHIRAL AMIDES AND AMINES - This invention provides a convenient method for converting oximes into enamides. The process does not require the use of metallic reagents. Accordingly, it produces the desired compounds without the concomitant production of a large volume of metallic waste. The enamides are useful precursors to amides and amines. The invention provides a process to convert a prochiral enamide into the corresponding chiral amide. In an exemplary process, a chiral amino center is introduced during hydrogenation through the use of a chiral hydrogenation catalyst. In selected embodiments, the invention provides methods of preparing amides and amines that include the 1,2,3,4-tetrahydro-N-alkyl-1-naphthalenamine or 1,2,3,4-tetrahydro-1-naphthalenamine substructure. | 2009-06-11 |
20090149550 | WRINKLE REDUCTION AGENT, LIPOLYSIS ACCELERATOR, COMPOSITION FOR EXTERNAL USE ON SKIN, AND FOOD OR BEVERAGE COMPOSITION - An antiwrinkle agent, lipolysis promoter, external composition for skin, and food and beverage composition having for an active ingredient thereof a compound represented by general formula (1): | 2009-06-11 |
20090149551 | OXIDIZED cis-TERPENONE AND ITS USE AS A CHEMOPROTECTIVE AND ANTI-MALARIAL AGENT | 2009-06-11 |
20090149552 | Pesticides based on vicinal diols - Pesticides based on vicinal diols, are available to control arthropod ectoparasites such as | 2009-06-11 |
20090149553 | INJECTABLE RESORBABLE BONE GRAFT MATERIAL, POWDER FOR FORMING SAME AND METHODS RELATING THERETO FOR TREATING BONE DEFECTS - An injectable resorbable bone graft material, and methods of using the same, provide increased compressive strength after injection in a bone defect. The bone graft material is made from calcium sulfate hemihydrate having a thick stubby rod-like crystalline structure and low water-carrying capacity. | 2009-06-11 |
20090149554 | WATER-SOLUBLE METAL ALCOHOLATE DERIVATIVES, PRODUCTION METHODS THEREOF, AND SOLID GELATINOUS EXTERNAL PREPARATIONS CONTAINING THE SAME - The object of the present invention is to provide a production method of water-soluble silane derivatives, the separation and purification of which are easy, and the reaction for which can be conducted under an industrially practicable temperature condition (under the temperature condition of 90° C. or lower) and to provide compounds with which solid gelatinous external preparations, with excellent stability against a temperature change and against an effect of additives and with excellent usability, can be prepared. The water-soluble silane derivative could be formed by the substitution reaction of a metal alkoxide with a polyhydric alcohol under the presence of a solid catalyst. According to this production method, the separation of the catalyst from the product is very easy, and the reaction can be carried out under the temperature condition of 90° C. or lower. The obtained water-soluble metal alcoholate derivative can satisfactory solidify an aqueous formulation of an external preparation by its blending thereinto. The obtained solid gelatinous external preparation has excellent stability against a temperature change and against the effect of additives. In addition, the external preparation is easily disintegrated during use; thus the usability such as easiness to be scooped up with fingers and spreadability during application is excellent. | 2009-06-11 |
20090149555 | METHOD FOR PREPARING POLYHYDROXYALKANOATES, POLYMERS THUS OBTAINED, COMPOSITIONS COMPRISING THEM AND THEIR USES - Method for preparing a polyhydroxyalkanoate (PHA) polymer by ring-opening polymerization of a lactone such as β-butyrolactone, that is preferably racemic, in which the polymerization is carried out in the presence of an initiator of formula (II): | 2009-06-11 |
20090149556 | Non-Tumorigenic Ointment/Cream Base for Topical Application - A non-tumorigenic skin care composition is provided. | 2009-06-11 |
20090149557 | Demulsifiers in solvent base for separating emulsions and methods of use - Demulsifiers containing an anionic surfactant selected from alkylsulfosuccinates, alkylphosphonic acids, and their salts; a nonionic surfactant selected from ethylene oxide/propylene oxide copolymers, ethoxylated fatty acids of polyethylene glycol, terpene alkoxylates, and modified alkanolamides; and solvent bases comprising blends of dibasic esters. Methods for breaking emulsions using such demulsifiers and solvent bases are also disclosed. | 2009-06-11 |
20090149558 | METHODS AND APPARATUS FOR CONTINUOUS REMOVAL OF CARBON DIOXIDE FROM A MIXTURE OF REACTING GASES - The disclosed invention provides methods and apparatus for producing one or more C | 2009-06-11 |
20090149559 | HEAT-EXPANDABLE MICROSPHERES, METHOD FOR PRODUCING THE SAME, AND APPLICATION THEREOF - Heat-expandable microspheres include a shell of thermoplastic resin and a blowing agent encapsulated therein having a boiling point not higher than the softening point of the thermoplastic resin, have a maximum expanding ratio not lower than 50 times, and are thermally expanded into hollow particulates having a repeated-compression durability not lower than 75 percent. The method of producing the heat-expandable microspheres includes the steps of dispersing an oily mixture containing a polymerizable component and the blowing agent in an aqueous dispersing medium containing a specific water-soluble compound and polymerizing the polymerizable component contained in the oily mixture. | 2009-06-11 |
20090149560 | POLYHYDROXYALKANOATE-BASED RESIN FOAMED PARTICLE, MOLDED ARTICLE COMPRISING THE SAME AND PROCESS FOR PRODUCING THE SAME - The object is to provide a molded product of foamed particles obtained by charging biodegradable resin foamed particles which are of vegetable origin and excellent in environmental compatibility into a mold, followed by heat molding, which molded product is not accompanied by post shrinkage after the molding with a wide range of variation of processing in the molding. Further, P3HA resin foamed particles being composed of a resin composition that comprises an isocyanate compound, and a polymer, poly(3-hydroxyalkanoate), having a recurring unit represented by the general formula (1): | 2009-06-11 |
20090149561 | EXTRUDED POLYMER FOAMS CONTAINING BROMINATED 2-OXO-1,3,2-DIOXAPHOSPHORINANE COMPOUNDS AS FLAME RETARDANT ADDITIVES - Extruded polymer foams are prepared using 5,5-bis(bromomethyl)-2-oxo-1,3,2-dioxaphosphorinane or brominated 2-oxo-1,3,2-dioxaphosphorinane compounds. The brominated FR additives unexpectedly are stable at the extrusion temperatures, and provide excellent flame retardancy to the foams. | 2009-06-11 |
20090149562 | PURIFICATION OF A DISTILLED BOTTOM PRODUCT CONTAINING (METH)ACRYLIC ACID BY MEANS OF A CRYSTALLIZATION PROCESS - A process for the preparation of (meth)acrylic acid is disclosed that includes:
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20090149563 | CROSSLINKABLE COMPOSITIONS FOR PAINT PRODUCTS - The present invention relates to a crosslinkable composition for paint products comprising: a) at least one acrylic oligomer that is crosslinkable through the combined action of heat and UV radiation; b) at least one acrylic oligomer that is crosslinkable through exposure to UV radiation alone; c) at least one acrylic monomer that is crosslinkable through exposure to UV radiation; d) at least one photoinitiator agent; e) at least one additive. The invention also relates to a thermo-crosslinkable paint product added with the aforementioned component, and a process for painting substrates of various natures, preferably car bodies and automotive parts thereof. | 2009-06-11 |
20090149564 | TRANSPARENT FLEXIBLE FILM AND FABRICATION METHOD THEREOF - A transparent flexible film is provided, formed by curing a composition, comprising: about 40-75 parts by weight of a clay; about 15-45 parts by weight of a water-soluble polymer; about 1-10 parts by weight of a mono-functional acrylic oligomer of formula (I), wherein n | 2009-06-11 |
20090149565 | Method for Making High Performance Mixed Matrix Membranes - The present invention discloses method for making defect-free high performance mixed matrix membranes (MMMs) containing a continuous polymer matrix and dispersed molecular sieves such as AlPO-14 or UZM-5. These MMMs can be used for separations. The novel method for making defect-free high performance MMMs comprises: post treating the MMM at a temperature ≧150° C. This new method results in a MMM with either no macrovoids or voids of less than 5 angstroms at the interface of the continuous polymer matrix and the molecular sieves. The MMMs are in the form of symmetric dense film, thin-film composite (TFC), asymmetric flat sheet or asymmetric hollow fiber. These MMMs have good flexibility and high mechanical strength, and exhibit high carbon dioxide/methane (CO | 2009-06-11 |
20090149566 | Fragrant gel polymer system - The fragrant gel polymer system is a process where a complete fragrance formulation remains whole and is then blended with either a polymer or a cross-linking agent. The non-fragrance carrying polymer is then liquefied and made homogenous with a solvent. The solvents modify viscosity and ease the mixing of the non-fragrance carrying polymer with the fragrance carrying polymer. The method also provides surfactants and wetting agents for further integration and mixing of the fragrance oils with either the polymer or the cross-linking agent during the steps of the process. Mixing of the fragrance carrying polymer and the non-fragrance polymer results in a gel that sets in less time and with less syneresis than existing processes. | 2009-06-11 |
20090149567 | Adhesive composition and wound dressings or ostomy appliances comprising such adhesive composition - An adhesive composition of a rubbery elastomeric matrix comprising a block-copolymer and a homopolymer where the block-copolymer contains one or more block(s) of a polymerised mono alkenyl arene monomer and one or more block(s) consisting of a linear or branched saturated hydrocarbon chain wherein the homopolymer is a linear or branched saturated hydrocarbon chain made from the same monomer as said block(s) consisting of a linear or branched saturated hydrocarbon chain. | 2009-06-11 |
20090149568 | Biodegradable Coatings For Implantable Medical Devices - Biodegradable coatings for implantable medical devices are disclosed. | 2009-06-11 |
20090149569 | SURFACE ENGINEERING OF TISSUE GRAFT MATERIALS FOR ENHANCED POROSITY AND CELL ADHESION - In one aspect, the invention relates to providing enhanced application tissue graft materials in regenerative medicine through improved cellular interactions. Biocompatible implant materials, methods for preparing biocompatible implant materials, methods for using same, and methods for treating tissue injury are disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 2009-06-11 |
20090149570 | Plasticizer, a biodegradable material comprising the plasticizer and application thereof - The present invention relates to a Plasticizer, which is fabricated by mixing monomers of biodegradable polymer with bio-molecules subsequently to deal the mixture with thermal treatment. The Biodegradable material comprising the Plasticizer has high melt index which is contributive for the processing of thermal processing, and the microwave-tolerance and water-resistance of the material makes the material suitable for food packaging. | 2009-06-11 |
20090149571 | METHODS AND SYSTEMS FOR CONVERTING WASTE INTO COMPLEX HYDROCARBONS - A method for receiving animal waste from animal confinements or other concentrated animal waste sources and for converting the waste into a complex hydrocarbon is described. The waste contains both liquids and solids. The method includes separating the liquids and solids into separate waste streams, controlling an amount of moisture in the solids waste stream such that the amount of moisture in the solid waste stream is compatible with a selected energy conversion process, and feeding the moisture controlled solid waste into the energy conversion process. The complex hydrocarbon may be suitable for use as a substitute or additive to petroleum-based asphalt binder. | 2009-06-11 |
20090149572 | MULTIPLE PARTICLE AND COMPOSITION HAVING DISPERSE SYSTEM - A multiple particle (e.g., a spherical particle) comprising an organic solid component (A) containing a plurality of organic solid materials (e.g., polymers) is produced by eluting a water-soluble auxiliary component (B) containing at least an oligosaccharide (B1) from a composition having a disperse system, in which a particulate dispersed phase comprising the organic solid component (A) is dispersed in a matrix comprising the auxiliary component (B). The organic solid materials may be different in affinity relative to the auxiliary component (B) from each other. The particle may have a core-shell structure which comprises a core containing a first organic solid material (e.g., a hydrophobic polymer) and a shell containing a second organic solid material (e.g., a hydrophilic polymer) immiscible with the first organic solid material. The weight ratio of the organic solid component (A) relative to the auxiliary component (B) may be about 55/45 to 1/99. The multiple particle corresponding to the dispersed phase (e.g., a core-shell particle) can be produced by a convenient process independently of affinity between the dispersed phase and the matrix and polymerization manner of the polymer. | 2009-06-11 |
20090149573 | SILICONE (METH)ACRYLATE PARTICLES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF - The present invention relates to silicone (meth)acrylate particles, to a process for preparing such silicone (meth)acrylate particles including the steps of:
| 2009-06-11 |
20090149574 | Iron Filled Urethane Cementitious Flooring Composition - Cementitious flooring compositions are products obtained by mixing together and allowing to cure hydraulic cement, water, iron aggregate filler, and resin forming components comprising polyisocyanate and an isocyanate reactive compound. The compositions are particularly suitable for flooring applications and the mixtures, once made up, set very rapidly. | 2009-06-11 |
20090149575 | LIQUID PRINTING INKS FOR FLEXOGRAPHIC AND/OR GRAVURE PRINTING USING HYPERBRANCHED POLYMERS AS BINDERS - Liquid printing inks for flexographic and/or gravure printing comprise solvents, colorants, if required additives, and, as a binder, at least one hyperbranched polymer having functional groups. Printing lacquers for priming unprinted print media or overcoating printed print media comprise solvents, if required additives, and, as a binder, at least one hyperbranched polymer having functional groups. Such hyperbranched polymers are used for the preparation of printing inks and of printing lacquers. | 2009-06-11 |
20090149576 | ELASTOMERIC MATERIAL USEFUL FOR MAKING INCREASED MODULUS RUBBER - A solid elastomeric reinforcing material for use in the manufacture of compounded rubber goods that is made from an elastomeric material coagulated from a natural or synthetic latex, a natural or synthetic fibrous filler that has a linear density of at least 0.5 dtex, a tenacity of at least 1.0 gram per dtex, a fiber length between 0.1 and 6 mm and a specific surface area range between 0.1-25 square meters per gram and a modulus enhancing additive. | 2009-06-11 |
20090149577 | Using Excess Levels of Metal Salts to Improve Properties when Incorporating Polymers in Asphalt - In methods of preparing asphalt and elastomeric polymer compositions such as polymer modified asphalt (PMA), it has been discovered that the compatibility can be improved by adding excess amounts of certain organic and inorganic metal salts beyond the proportions normally used. Suitable metal salts may be metal oxides that include, but are not necessarily limited to, zinc oxide, calcium oxide, and the like. The method of the invention also permits asphalt modified with other polymers such as ground tire rubber (GTR) to have improved compatibility. Additionally, the use of excess amounts of these metal salts helps control gel formation. | 2009-06-11 |
20090149578 | Block copolymer and method for producing same, composition for resin modification and modified resin composition, and method for producing same - A comprising conjugated diene monomer units, and at least one polymer block B comprising conjugated diene monomer units and aromatic vinyl monomer units. This block copolymer is characterized in that (1) the polymer block A has a glass transition temperature of −88° C. to −45° C., (2) the polymer block B has a glass transition temperature of 30° C. to 90° C., (3) the content of aromatic vinyl monomer units in the whole block copolymer is 3-52 wt. %, (4) the aromatic vinyl block ratio in the whole block copolymer is smaller than 69 wt. %, and (5) the viscosity of a 5 wt. % solution of the block copolymer in styrene is 30-80 mPa·s. The block copolymer is useful as a resin modifier. | 2009-06-11 |
20090149579 | POLYROTAXANE-CONTAINING SOLUTION AND USE THEREOF - An object of the present invention is to provide a polyrotaxane-containing solution by finding a good solvent for polyrotaxanes, and more particularly, to provide a polyrotaxane-containing solution by finding a good solvent for polyrotaxanes with a cyclodextrin as the cyclic molecule(s). | 2009-06-11 |
20090149580 | NON-YELLOWING FLOCK ADHESIVE - Disclosed is a flock adhesive composition having a polyurethane coating comprising about 90 to 99 dry weight percent of a polyurethane component consisting essentially of the reaction product of a diisocyanate, a poly(alkylene oxide) polyol, and a di or tri-functional hydroxyl compound; wherein when subjected to a UV exposure of 601 kJ/m2 the resulting color change comprises a delta E of less than 9.0 and a delta b of less than 5.0. The flock adhesive is resistant to natural yellowing and can be employed as a clear flock adhesive or combined with pigment to provide a color stable flock adhesive. | 2009-06-11 |