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23rd week of 2015 patent applcation highlights part 9
Patent application numberTitlePublished
20150150989Plasticizers For Coating Compositions - A biocompatible plasticizer useful for forming a coating composition with a biocompatible polymer is provided. The coating composition may also include a biobeneficial polymer and/or a bioactive agent. The coating composition can form a coating on an implantable device. The implantable device can be used to treat or prevent a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof2015-06-04
20150150990ORAL PHARMACEUTICAL COMPOSITIONS IN A SOLID DISPERSION COMPRISING PREFERABLY POSACONAZOLE AND HPMCAs - The present application provides novel compositions comprising posaconazole and a polymer wherein the composition has a glass transition temperature temperature (Tg) of less than about 110° C. The application also describes compositions comprising posaconazole and a polymer having a bulk density of greater than about 0.4 mg/mL. The application also describes compositions comprising posaconazole and a polymer which provide an exposure (AUCtf) of at least about 10,000 ng·hr/mL when administered to a patient in a fasted state. The application also describes a novel process for preparing these compositions.2015-06-04
20150150991NOVEL SUSTAINED RELEASE DOSAGE FORM - The novel sustained release dosage form comprising an active agent and a combination of a non-swelling pH dependent release retardant and a non swelling pH independent release retardant polymer which provides pH-independent drug release for a considerable period of time after administration.2015-06-04
20150150992COMPOSITION FOR THE PHOTODYNAMIC DIAGNOSIS AND THERAPY OF TUMOURS - The present invention relates to a composition which can be used in particular in the photodynamic diagnosis and/or therapy of tumours. The invention relates further to the use of albumins for stabilising chlorin e6 or pharmaceutically acceptable derivatives thereof.2015-06-04
20150150993SILK MICROSPHERES AND METHODS FOR SURFACE LUBRICATION - Provided herein relates to compositions and methods for lubrication of a surface. The surface amenable to the compositions and methods described herein can be a non-biological surface, a biological surface, or a combination thereof. In some embodiments, the composition comprising a phospholipid-coated silk microsphere can be used for lubrication of a surface. In some embodiments, the composition comprising a phospholipid-coated silk microsphere can be used for joint lubrication, e.g., for treatment of joint disorders such as arthritis.2015-06-04
20150150994LIVER TARGETED DRUG DELIVERY SYSTEMS USING METAL NANOPARTICLES AND PREPARING METHOD THEREOF - The present invention relates to liver targeted drug delivery system using metal nanoparticles and a method for preparing the same. More particularly, the present invention relates to a method for preparing hyaluronic acid-gold nanoparticles/protein complex that can be used as liver targeted drug delivery system, by surface modifying gold nanoparticles having excellent stability in the body with hyaluronic acid having biocompatibility, biodegradability and liver tissue-specific delivery property, and binding protein drugs for treating liver diseases to the non-modified surface of the gold nanoparticles. And, the present invention relates to use of the hyaluronic acid-gold nanoparticles/protein complex for liver disease drug that may be safely applied to human body, increase drug efficacy duration time, and be effectively delivered to liver.2015-06-04
20150150995CONJUGATED ANTI-MICROBIAL COMPOUNDS AND CONJUGATED ANTI-CANCER COMPOUNDS AND USES THEREOF - Disclosed herein are synthesis methods for generation of conjugated anti-microbial compounds and conjugated anti-cancer compounds. Several embodiments, related to the uses of such compounds in the treatment of infections, in particular those caused by drug-resistant bacteria. Some embodiments relate to targeting cancer based on the metabolic signature of tumor cells.2015-06-04
20150150996COMPOSITIONS AND METHODS FOR ANTIGEN-SPECIFIC TOLERANCE - The present invention provides compositions and methods for inducing antigen-specific tolerance in a subject. In one embodiment, the present invention provides a composition comprising an apoptotic body and an epitope of an antigen. Also provided herein are methods of preparing and administering the composition. The composition and methods provided herein can induce antigen-specific tolerance in a subject.2015-06-04
20150150997Activated Sialic Acid Derivatives For Protein Derivatisation And Conjugation - Derivatives of PSAs are synthesised, in which a reducing and/or non-reducing end terminal sialic acid unit is transformed into a N-hydroxysuccinimide (NHS) group. The derivatives may be reacted with substrates, for instance substrates containing amine or hydrazine groups, to form non-cross-linked/crosslinked polysialylated compounds. The substrates may, for instance, be therapeutically useful drugs, peptides or proteins or drug delivery systems.2015-06-04
20150150998METHODS FOR OXIME CONJUGATION TO KETONE-MODIFIED POLYPEPTIDES - The invention provides improved methods to prepare protein conjugates from a ketone-modified protein. In one embodiment, the protein is prepared by linking two free cysteines by reaction with a 1,3-dihaloacetone or similar ketone-containing reactant, linking the sulfur atoms of the two cysteines together. The ketone inserted between the sulfur atoms is then used to form an oxime, thus conjugating the protein to a payload. In another embodiment, two cysteine residues are tied together by reaction with a 1,3-dihaloacetone or similar reactant, and the new ketone is used to form an oxime with a suitable payload molecule, thus conjugating the protein to a payload. The method provides improved reaction conditions for the oxime formation, whereby higher yields and improved product homogeneity are achieved.2015-06-04
20150150999POLYMER-NSAID CONJUGATE - The invention relates to polymer-drug conjugate for delivering a substituted alkanoic acid non-steroidal anti-inflammatory drug (NSAID). The invention also relates to drug delivery systems comprising the polymer-NSAID conjugate. The polymer-NSAID conjugates comprise a substituted alkanoic acid non-steroidal anti-inflammatory drug (NSAID) conjugated to a biodegradable polymer backbone by an ester linkage.2015-06-04
20150151000PEPTIDE CONJUGATES FOR TREATING PAIN - Described herein are compounds, composition, and methods for treating pain. In particular, described herein compounds, compositions, and methods that modulate the protein-protein-interaction between CRMP-2 and a calcium channel for treating pain.2015-06-04
20150151001COMPOSITIONS AND METHODS FOR DETECTING OR ELIMINATING SENESCENT CELLS TO DIAGNOSE OR TREAT DISEASE - Disclosed are agents (e.g., peptides, polypeptides, proteins, small molecules, antibodies, and antibody fragments that target senescent cells) and methods of their use for imaging senescent cells in vivo and for treating or preventing cancer, age-related disease, tobacco-related disease, or other diseases and disorders related to or caused by cellular senescence in a mammal. The methods include administering one or more of the agents of the invention to a mammal, e.g., a human. The agents, which specifically bind to senescent cells, can be labeled with a radioactive label or a therapeutic label, e.g., a cytotoxic agent.2015-06-04
20150151002TARGETED THERAPY FOR THE PREVENTION OF RESTENOSIS IN THE CARDIOVASCULAR SYSTEM - Provided herein are compositions and methods for targeted drug delivery to prevent restenosis in the cardiovascular system. In particular, provided herein are nanoscale delivery vehicles for drugs that prevent proliferation and neointimal hyperplasia.2015-06-04
20150151003MAYTANSINOID DERIVATIVES - Disclosed herein are maytansinoid drug linker derivatives which can be linked to a antigen binding unit (Abu), and maytansinoid drugs linked with an antigen binding unit (Drug-Linker-Antigen binding Unit: D-L-Abu), for targeted delivery to disease tissues. D-L-Abu, D-L-Abu derivatives, and methods relating to the use of such drug conjugates to treat antigen positive cells in cancers and immunological disorders are provided.2015-06-04
20150151004METHODS AND COMPOSITIONS OF MODULATING TUMOR INITIATING CELLS AND THE USE THEREOF - A therapeutic vector can include: a lipid particle; a CD44 antigen targeting moiety associated with the lipid particle; and a therapeutic nucleic acid associated with the lipid particle. The CD44 antigen targeting moiety can be anti-CD44 antibody and/or anti-CD44 scFv. The lipid particle can have a formula according to one of the following: DOTAP/DOPE 1:1 molar ratio; DDAB/DOPE 1:1 molar ratio; DDAB/DOPE 1:2 molar ratio; DOTAP/Chol 1:1 molar ratio; DDAB/Chol 1:1 molar ratio; DOTAP/DOPE/Chol 2:1:1 molar ratio; and DDAB/DOPE/Chol 2:1:1 molar ratio. The molar ratios can range +/−1%, 5%, 10%, or 20%. A method of inhibiting cancer development can include: providing the therapeutic vector and administering the therapeutic vector to the subject in an amount to inhibit cancer development.2015-06-04
20150151005MICROPARTICLES AND NANOPARTICLES MADE UP OF HYDROPHOBIZED POLYSACCHARIDES AND AN ALPHA-CYCLODEXTRINE - Microparticles and nanoparticles of hydrophobized polysaccharide and an alpha-cyclodextrin, obtained by self-association in an aqueous medium, the hydrophobized polysaccharide being obtained by grafting of alkyl chains derived from fatty acids, by an acylation reaction. These microparticles and nanoparticles constitute systems used for encapsulating substances of interest, in particular in the pharmaceutical field, and vectorization thereof for therapeutic purposes.2015-06-04
20150151006Compositions and Methods for Gene Therapy - Compositions and methods for the delivery of a protein and/or nucleic acid of interest are provided.2015-06-04
20150151007GENE THERAPY FOR LYSOSOMAL STORAGE DISEASES - This disclosure provides methods and compositions for treating lysosomal storage diseases in a subject. In one aspect of the invention, a transgene product is delivered to a subject by administering a recombinant neurotrophic viral vector containing the transgene to the brain. The viral vector delivers the transgene to a region of the brain which is susceptible to infection by the virus and which expresses the encoded recombinant viral gene product. Also provided are compositions for delivery of a transgene product to a subject by administering a recombinant neurotrophic viral vector containing the transgene to the subject's brain. The transgene product may be any that is deficient in a lysosomal storage disease.2015-06-04
20150151008Contrast Media Taste Masking Formulations - The disclosure provides oral solid particle formulations comprising of an iodinated imaging agent and at least one taste masking agent showing improved bioadhesive properties, and are also useful for imaging of the gastrointestinal tract.2015-06-04
20150151009TRIARYLMETHYL RADICALS - New radical compounds, useful in the field of MRI imaging of formula (I). The radical compounds are in particular new triarylmethyl (“trityl”) radicals which can be used as polarizing agents for polarizing a molecule in the DNP process.2015-06-04
20150151010Plectin-1 Targeted Agents for Detection and Treatment of Pancreatic Ductal Adenocarcinoma - Described herein are compositions and methods for cancer cell biomarkers, such as pancreatic ductal adenocarcinoma (PDAC) cell biomarkers, and binding molecules for diagnosis and treatment of cancer, e.g., PDAC. Methods of identifying “accessible” proteomes are disclosed for identifying cancer biomarkers, such as plectin-1, a PDAC biomarker. Additionally, imaging compositions are provided comprising magnetofluorescent nanoparticles conjugated to peptide ligands for identifying PDACs.2015-06-04
20150151011Preparation of Technetium-99M Tricarbonyl Labeled Glycine Monomer or Oligomer Containing Probes That Have Biomolecules and Its Application as Imaging Complex-Composition - Disclosed is a technetium-99m-labeled glycine oligomer associated with imaging probes for biomolecules of interest. The glycine oligomer can be readily synthesized in a single process using an automated peptide synthesizer. The technetium-99m tricarbonyl-labeled glycine oligomers can be useful as a radiotracer for gamma or SPECT imaging apparatus. The technetium-99m tricarbonyl-labeled glycine oligomers can be applied to various peptidyl biomolecules such as RGD peptide, somatostatin, neurotensin, etc., and exhibit rapid renal clearance without being excessively retained within the body.2015-06-04
20150151012DISINFECTION APPARATUS - The invention relates to an apparatus (100) and a method for the disinfection of skin areas, particularly for the disinfection of hands (H). Disinfection is achieved by application of a short IR light pulse emitted by at least one IR source(103) to the skin area. The parameters of the light pulse are chosen such that germs at the skin surface are killed while damaging of deeper skin layers is prevented.2015-06-04
20150151013METHOD FOR STERILIZING MEMBRANE COMPRISING AND OXIDOREDUCTASE ENZYME AND ASSOCIATED BIOSENSOR - A method for sterilizing a membrane comprising an oxidoreductase enzyme in an environment having a relative humidity, comprises: irradiating the membrane comprising an oxidoreductase enzyme with gamma radiation under vacuum at a relative humidity lower than the relative humidity of the environment. Associated biosensors are also described.2015-06-04
20150151014Method and Device For Disinfection and/or Purification Of A Product - The present invention relates to a method and device for illuminating and at the same time purifying or disinfecting products such as air, flowers, food, vegetables, meat, poultry or fish. The method comprises the use of IR emitting LED elements.2015-06-04
20150151015ENVIRONMENTAL CLEANING AND ANTIMICROBIAL LIGHTING COMPONENT AND FIXTURE - A system and method according to various embodiments combines three separate technologies to form a unique lighting system with enhanced antimicrobial properties and air cleaning capabilities. The combination of the three technologies also produces a lighting system that extends the required maintenance period for lighting fixtures. The first technology is based on anatase type TiO2015-06-04
20150151016SANITATION APPARATUS FOR BUTTONS - An apparatus for disinfecting a button including a housing having an inner side and an outer side. At least one button is disposed within the housing, the button having a rotational symmetry allowing rotation of the button with respect to the housing. A rotation mechanism rotates the button with respect to the housing. A disinfecting system positioned on the inner side of the housing disinfects a portion of the button that is exposed on the inner side of the housing. The rotation mechanism rotates the button at a substantially constant speed. The apparatus provides a safer operation of the button as there is a continuous sanitizing of the surface of the button contaminated by users.2015-06-04
20150151017STERILIZATION CASSETTE SYSTEMS, INSTRUMENT RETENTION SYSTEMS FOR A USE WITH A STERILIZATION CASSETTE, AND CONFIGURABLE INSTRUMENT RETENTION MEMBERS FOR USE THEREWITH - Sterilization cassette systems, instrument retention systems for use with a sterilization cassette, and configurable instrument retention members are disclosed that are suitable at least for holding medical and/or dental instruments during sterilization in an autoclave.2015-06-04
20150151018Catalytic Fragrance Burner Assembly and a Method of Manufacture Thereof - A catalytic fragrance burner assembly, comprising: a porous core of sintered material; a catalyst, deposited on or around the core; and a wick, in communication with the porous core, and arranged to draw fuel to the core.2015-06-04
20150151019FUNCTIONALIZED SURGICAL ADHESIVES - A bioadherent composition includes a first mixture containing a plurality of reactive members of a specific binding pair, said reactive members being bound to a ligand capable of binding a receptor on biological tissue, and a second mixture containing a plurality of complementary reactive members of the specific binding pair, said complementary reactive members being bound to a ligand capable of binding a receptor on biological tissue, said reactive members capable of forming covalent bonds with said complementary reactive members via a reaction selected from Huisgen cycloaddition reactions, Diels-Alder reactions, and/or thiol-alkene reactions. A method for bonding biological tissue involves utilizing the bioadherent composition.2015-06-04
20150151020FORMED SHEET PRODUCT AND HEMOSTATIC MATERIAL - A formed sheet product of a polymer composition comprising at least one protein selected from the group consisting of fibrinogen and thrombin and at least one polymer selected from the group consisting of an aliphatic polyester and a water-soluble polymer, and a laminated formed sheet product comprising a first polymer composition layer composed of fibrinogen and a water-soluble polymer and a second polymer composition layer composed of thrombin and an aliphatic polyester are provided. These formed products are applied onto a wound site and function as a hemostatic material.2015-06-04
20150151021SOFT HYDROPHOBIC ACRYLIC MATERIALS - Soft hydrophobic acrylic materials with improved resistance to fluid diffusion and suitable mechanical properties that allow deformation upon application of force are disclosed. The acrylic materials are particularly suitable for use in fluid-based accommodating intraocular lenses and comprises combination of a perfluoro-substituted alkyl (meth)acrylate and an alkyl (meth)acrylate, and a cross-linking agent.2015-06-04
20150151022SOFT ACRYLIC MATERIALS WITH HIGH REFRACTIVE INDEX AND MINIMIZED GLISTENING - High refractive index acrylic device materials with reduced glistenings are disclosed. The device materials are particularly suitable for use as ophthalmic or otorhhinolaryngological device materials and comprises a poly(phenyl ether)-containing monomer and/or a poly(phenyl ether)-containing cross-linking agent.2015-06-04
20150151023MULTI-MODAL SHAPE MEMORY POLYMERS - The present disclosure relates to a multi-modal shape memory polymer material comprising a blend or at least one polymer component having a first molecular weight and at least a second polymer component having a second molecular weight that is less than the first component.2015-06-04
20150151024Selectively Absorbable/Biodegradable Fibrous Composite Constructs and Applications Thereof - A family of selectively absorbable/biodegradable, fibrous composite constructs includes different combinations of biostable and absorbable/biodegradable yarns assembled as initially interdependent, load-bearing components, transitioning to exhibit independent functional properties during in vivo end-use. The family of constructs consists of two groups, one group is made of fiber-reinforced composites of high compliance, absorbable matrices of segmented polyaxial copolyesters reinforced with multifilament yarn constructs, which are combinations of ultrahigh molecular weight polyethylene fibers and at least one absorbable/biodegradable fiber selected from silk fibers and multifilament yarns made from linear segmented, l-lactide copolyesters and poly (3-hydroxyalkanoates, are useful in orthopedic, maxillofacial, urological, vascular, hernial repair and tissue engineering applications. The second group is made of coated and uncoated, warp-knitted mesh constructs for use in hernial, vascular, and urological tissue repair and tissue engineering.2015-06-04
20150151025Antimicrobial Hydrochloric Acid Catheter Lock Solution and Method of Use - A catheter lock solution includes a hydrochloric acid solution having a concentration of 0.3 Molar to 1.0 Molar. This hydrochloric acid solution may be used to lock a catheter and/or salvage an infected catheter.2015-06-04
20150151026IMPLANTABLE DEVICE HAVING OSSEOINTEGRATING PROTUBERANCES - An implantable device for mounting to a patient's bone includes a housing and at least one osseointegrating protuberance. The housing includes a surface having an abutting portion configured to abut the bone when the housing is implanted in the patient, the abutting portion defining a housing axis orthogonal to the surface. The at least one osseointegrating protuberance: extends from the surface of the housing; is adapted to abut the patient's bone; and has a substantially smooth shaft.2015-06-04
20150151027Bioabsorbable Medical Device or Medical Device Component and Preparation Method Thereof - A bioabsorbable medical device or a medical device component comprises an absorbable component prepared by subjecting a prefabricated component of an iron-based raw material to ion nitriding. Substance composition inside the absorbable component changes with the depth from the surface. The absorbable component comprises at least a first part and a second part. The first part surrounds the second part. Hardness of the first part is higher than hardness of the second part. An interface exists between the first part and the second part. A crack generated in the first part is impeded by the interface when extending to the second part. On the premise of ensuring radial stand strength, the bioabsorbable medical device or medical device component and a preparation method thereof reduce wall thickness of an iron-based stand, improve a stand corrosion rate and malleability, and achieve broader adaptability.2015-06-04
20150151028Tropoelastin for Promoting Endothelial Cell Adhesion or Migration - The invention provides methods, compositions, and devices for promoting adhesion or migration of endothelial cell.2015-06-04
20150151029IMPLANTABLE POLYMERIC DEVICE FOR SUSTAINED RELEASE OF DOPAMINE AGONIST - The present invention provides compositions, methods, and kits for treatment of Parkinson's disease and other conditions for which treatment with a dopamine agonist is therapeutically beneficial. The invention provides a biocompatible nonerodible polymeric device which releases dopamine agonist continuously with generally linear release kinetics for extended periods of time. Dopamine agonist is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with dopamine agonist.2015-06-04
20150151030BIOABSORBABLE COATING WITH TUNABLE HYDROPHOBICITY - The present invention relates to implantable medical devices coated with polymer having tunable hydrophobicity and their use in the treatment of vascular diseases.2015-06-04
20150151031MOLDED VAD - Various blood pumps and methods of manufacture therefor are disclosed. An embodiment of a blood pump comprises a blood-flow lumen having an inlet and an outlet, and a rotor within the blood-flow lumen, the rotor having an impeller for pumping blood through the blood pump. A motor is also provided including a plurality of magnetic poles carried by the rotor, and a stator including a plurality of electrically conductive coils adjacent to and at least partially surrounding the blood-flow lumen. An over-molded monolithic enclosure covers the stator, the enclosure at least partially sealingly enclosing the stator and encasing the blood-flow lumen.2015-06-04
20150151032SPEED CHANGE ALGORITHIM FOR A CONTINUOUS FLOW BLOOD PUMP - A ventricular assist device (“VAD”) includes a continuous-flow pump (2015-06-04
20150151033Fluid Volume Monitoring for Patients with Renal Disease - A method includes initiating a blood fluid removal session of a patient; monitoring an indicator of tissue fluid volume of the patient, or a portion thereof, during the blood fluid removal session; monitoring an indicator of blood fluid volume of the patient during the blood fluid removal session; determining whether a ratio of the indicator of tissue fluid volume to indicator of blood fluid volume is outside of a predetermined range; and altering the rate of fluid removal during the blood fluid removal session if the ratio is determined to be outside of the predetermined range. A blood fluid removal system may be configured to carry out the method.2015-06-04
20150151034Methods of Administering Nitric Oxide to Arterial or Arterialized Blood - The present invention provides methods of administering nitric oxide (NO) to a patient, the method comprising delivering nitric oxide-containing gas directly into arterial or arterialized blood. The methods of the present invention may be used in the treatment or prevention of a variety of diseases and disorders responsive to nitric oxide, including those resulting from ischemia or hypoxia.2015-06-04
20150151035DEVICE AND FILTER CARTRIDGE FOR SEPARATING PLASMA FROM WHOLE BLOOD - A multi-part device for separating plasma from whole blood is provided, with a sample taking unit for receiving whole blood, a filter unit with a layered filter with multiple layers for extracting plasma, and a pumping unit, typically a plunger pump, for creating a partial vacuum in the filter unit. The filter unit and a plasma collector vessel with a conical tip extending towards the filter unit are contained in a filter cartridge, which may be taken apart after plasma extraction, thus exposing the conical tip of the plasma collector vessel for sample input into an analyser.2015-06-04
20150151036BLOOD PURIFICATION APPARATUS AND PRIMING METHOD FOR THE SAME - The present teachings provide a blood purification apparatus and a priming method, which can reduce or dispense with dedicated components used for automated priming and which can reduce manufacturing costs of a blood circuit while achieving the automated priming. The present teachings further provide a blood purification apparatus including a liquid level adjustment device that can optionally introduce or discharge air into or from an upper portion of a venous air trap chamber, a control device that can adjust a liquid level formed inside the venous air trap chamber to have the height at any desired position by operating the liquid level adjustment device, and a priming solution supplying line that can supply a priming solution to an arterial blood circuit and a venous blood circuit. As taught herein, during priming, the control device can fill the arterial blood circuit and the venous blood circuit with priming solution supplied from the priming solution supplying line by operating the liquid level adjustment device at any desired timing.2015-06-04
20150151037DEVICE FOR BIO-AFFINITY MATERAL - Apparatus for contacting body fluids with the bio-affinity material is disclosed. The apparatus includes a container having top and bottom lock covers that clip onto the container.2015-06-04
20150151038MULTI-CONDUIT BALLOON CATHETER - A suctioning and irrigating sinus balloon catheter is provided for treating a patient's paranasal sinus system, including dilating prepared openings, and natural ostia and ducts and excising sinus cavities and choana. The catheter has a number of fluid carrying conduits to provide irrigation, suction and inflation/deflation to the distally mounted balloon. The catheters have sufficient stiffness and column strength that the balloon carrying distal segment of the catheter can be pushed into the prepared opening, natural ostium or duct, choana or sinus to be excised. Some catheters can be hand bendable by the surgeon. Some catheters provide the capability of threading an endoscope through one of the conduits. The methods use the balloon catheters to dilate prepared openings to selected parts of the sinus system, to dilate natural ostia and ducts of the sinus system, choana, and/or to dilate sinus cavities to remove them.2015-06-04
20150151039INJECTOR FOR THE INJECTION OF A FLUID AND METHOD FOR THE CONTROL OF AN INJECTOR - An injector for the injection of a fluid into human or animal bodies with a pump for the conveying of the fluid at a flow rate, and with a control device for the control of the pump and for the setting of a desired flow rate (theoretical flow) of the fluid, and a pressure measurement device coupled with the control device for the recording of the pressure of the fluid conveyed by the pump, wherein a theoretical pressure is specified for the control device. In order, on the one hand, to reliably prevent an exceeding of a pressure hazard in the injection system and, on the other hand, to avoid an unnecessary prolongation of the injection process by a power reduction or a switching off of the drive mechanism, and to increase the throughput of several injection processes carried out with the injector one after the other, provision is made so that the control device compares the pressure of the fluid recorded by the pressure measurement device to the theoretical pressure, and when the theoretical pressure is exceeded over a time period, integrates the chronological pressure course of the pressure recorded by the pressure device over this time period for the determination of a pressure integral, and switches off the pump or operates it with a lower pump power if the determined pressure integral exceeds a prespecified integral limiting value.2015-06-04
20150151040CONTROLLER FOR THE AUTOMATIC CONTROL OF AN INJECTION DEVICE - The invention concerns an device for injecting a patient with a liquid product contained in a container (2015-06-04
20150151041Automatic Device for Transferring Fluid - A transfer station for transferring a medical fluid between at least one supply container and at least one administration container of an infusion device is described. In an embodiment, the transfer station comprises at least one supply port configured for fluidic connection of the at least one supply container to the transfer station, and at least one exit port configured for fluidic connection of the at least one administration container to the transfer station. A transfer mechanism for automatically transferring a predetermined amount of medical fluid from the at least one supply container to the at least one administration container, and an electronic processing unit connected to an actuation means are provided with the transfer station. A processing unit controls the transfer mechanism and fluid transfer conditions according to a predetermined transfer demand entered by the actuation means.2015-06-04
20150151042PROSTHESIS HAVING CONTROL FUNCTION - The present invention relates to a prosthesis having a control function, which can be implanted under the skin of a human body and an animal and can be controlled so as to intentionally and intermittently secrete drugs stored in a chamber and a lumen. The prosthesis has an exterior of an I-shape or a C-shape when viewed from top. The prostheses can be used for drug administration and treatment in male erectile dysfunction, treatment of hypersensitivity reaction for penis dwarfism and dwarfism, drug administration in conversion from off-state to on-state for the treatment of Parkinson's syndrome, drug administration in treatment necessary for multi-frequency and long-time administration, administration of drugs reduced or lost in pharmacological activity in digestive system, drug administration after stereotactic surgery for brain disease, and drug administration in a treatment method of directly administering drugs on a lesion to avoid delayed effect of drug.2015-06-04
20150151043RESERVOIR MODULE COMPRISING A PISTON ROD - A product dispensing apparatus including a reservoir module, a dosing module and a dose setting member. The reservoir module includes a front casing section, a block, a first connector, a piston, and a piston rod moveable in a dispensing movement and against the dispensing movement, and including a return block engageable with the block, wherein engagement between the block and the return block prevents the piston rod from moving against the dispensing movement. The dosing module includes a rear casing section, including a second connector which is engageable with the first connector to form a detachable connection between the reservoir module and the dosing module, and a dosing and drive device. The dose setting member engages the piston rod such that it is moveable together with and in the same direction as the piston rod during the dispensing movement and is moveable relative to the piston rod against the dispensing movement.2015-06-04
20150151044METHOD OF MANUFACTURING A PROPELLANT CONTAINER - A method of manufacturing a container containing propellant includes2015-06-04
20150151045METHOD OF MANUFACTURING A PROPELLANT CONTAINER - A method of manufacturing a container containing propellant includes 2015-06-04
20150151046Linear Actor Arrangement - The invention relates to a linear actor arrangement, comprising a linear actor with two ends whose distance is variable depending on an energizing of the linear actor, wherein each end is attached to a respective first or second coupling element which engage a coupling surface, wherein the coupling surface and the coupling elements exhibit mating surface structures in such a manner that the coupling elements are prevented from moving in a direction while being allowed to move in an opposite direction.2015-06-04
20150151047SYRINGE - A syringe propellable by propellant that boils at a predetermined temperature, the syringe including a barrel having an outlet at a front end, and a stopper axially moveable in the barrel. The stopper separates a first chamber and a second chamber, the first chamber being axially forwards of the stopper and being configured for containing a medicament, and the second chamber being axially rearwards of the stopper and being configured to receive propellant for acting on the stopper to move the stopper axially forwardly in the barrel to expel medicament through the outlet upon actuation of the syringe. The syringe further includes a third chamber for containing propellant. Upon actuation of the syringe, liquid propellant is released from the third chamber and boils outside of the third chamber at or above the predetermined temperature to provide an increasing vapor pressure in the second chamber that causes the stopper to move axially forwardly and begin to expel medicament through the outlet. At least one trigger for triggering an action is provided, the trigger activated in response to the pressure in the second chamber satisfying a predetermined condition.2015-06-04
20150151048AUTOMATIC INJECTION DEVICE - An object of the present invention is to provide an automatic injection device that allows setting of conditions of puncture according to the thickness of a syringe needle, the puncture depth, and so forth to reduce pain in the puncture and reduce the impact in the puncture to allow alleviation of anxiety and fear of a patient. An automatic injection device of the present invention has a syringe holder that holds a syringe attachably and detachably, a first drive unit that causes the syringe holder holding the syringe to advance to perform puncture by a syringe needle, and a control unit that controls the first drive unit to control the puncture speed.2015-06-04
20150151049ON-BODY INJECTOR AND METHOD OF USE - An on-body injector and method of use including an on-body injector for use with an injection device. The on-body injector includes a bolus reservoir; a bolus injection needle in fluid communication with the bolus reservoir, the bolus injection needle having a bolus injection needle tip aligned with the injection port, the bolus injection needle being slideably biased away from the injection port to define a gap between the bolus injection needle tip and the injection port; and a button operably connected to the bolus injection needle to slide the bolus injection needle along the injection axis. The button is operable to advance the bolus injection needle tip to close the gap and advance the bolus injection needle tip into the injection port. The button is further operable to advance a plunger through the bolus reservoir to deliver a predetermined bolus volume to the patient through the injection flow path.2015-06-04
20150151050Infusion Pump System and Method - Some embodiments of an infusion pump system may be configured to allow the user to communicate with the infusion pump system using voice or image input. Optionally, particular embodiments can interpret the voice or image input using speech or image recognition capabilities. By incorporating speech or image recognition equipment within the infusion pump system, user interactions with the pump system can be enhanced and simplified.2015-06-04
20150151051Device and System for Locating and Operating a Medical Device - A device for locating and operating a medical device having different operational modes is provided. The device comprises a first database, wherein from a plurality of different operational modes for the medical device and from a plurality of different geographical positions of use for operation of the medical device, a predetermined operational mode is assigned to a geographical position of use. A positioning means is adapted to be provided at the medical device and to determine the geographical position of the medical device, and a control means is connected to the positioning means and the database and is adapted to determine, by mapping the determined geographical position of the medical device with the geographical positions of use stored in the first database, the predetermined operational mode which is assigned to the geographical position where the medical device is located, and to set the medical device to said predetermined operational mode.2015-06-04
20150151052SYRINGE - A syringe is disclosed. The syringe may include a syringe body with a fluid chamber, the syringe body having a distal end and a proximal end, with an extrusion opening at the proximal end; a dividing wall disposed within the fluid chamber, defining a first fluid chamber and a second fluid chamber, the first fluid chamber and the second fluid chamber in communication with the extrusion opening; a first plunger disposed in a distal end of the first chamber, the first plunger including a first locking mechanism configured to prevent the first plunger from sliding away from the proximal end of the syringe body, when the first plunger is in a first initial position and the second plunger is being depressed; and a second plunger disposed in a distal end of the second chamber, the second plunger including a second locking mechanism configured to prevent the second plunger from sliding away from the proximal end of the syringe body when the second plunger is in a second initial position and the first plunger is being depressed.2015-06-04
20150151053Medicament Delivery Device - The present invention relates to a medicament delivery device (2015-06-04
20150151054Blood Collection Device with Double Pivot Shields - A shieldable needle device including a shield assembly having a first shield member extending from a first side of a hub and a second shield member extending from a second side of the hub, the second side being substantially opposite the first side is disclosed. The shield assembly is pivotable between an open position in which a needle cannula is exposed and the first shield member is spaced apart from the second shield member and a shield position in which the first shield member contacts the second shield member and at least a portion of the first shield member and the second shield member are disposed over the distal end of the needle cannula. In one embodiment, the hub, the first shield member, and the second shield member form an integral component.2015-06-04
20150151055SYRINGE WITH NEEDLE GUARD INJECTION DEVICE - The present invention provides for an injection device including a syringe with a proximal end, a distal end, a needle extending from the distal end, and a plunger inserted into the proximal end. A guard is slidable on the syringe, has a proximal end, a distal end, and is biased from a first position wherein the needle is exposed towards a second position wherein the guard covers the needle. The injection device includes first and second sets of cooperating detents for retaining the guard and syringe in the first and second positions, respectively. A latch member extends proximally from the guard that is engageable by the plunger as the plunger is depressed to release the first set of cooperating detents. Upon release, a spring element biases the guard towards the second position until the second set of cooperating detents engage and secure the guard in the second position.2015-06-04
20150151056SAFETY SYRINGE - A safety syringe includes a barrel having a positioning groove, a needle holder mounted in the barrel and having a first internal flange engaged in the positioning groove of the barrel and a first positioning flange, an interlocking seat mounted in the needle holder and having an elastic flap and a first external flange, and a plunger mounted in the barrel and having a second external flange. By means of engagement between the elastic flap of the interlocking seat and the second external flange of the plunger, the interlocking seat can be pulled by the plunger to let the first external flange to be forced into engagement with the first internal flange of the needle holder for allowing the needle holder with an attached needlestick to be pulled backwardly into the inside of the barrel to assure the safety of the syringe after the injection.2015-06-04
20150151057INFUSION PUMP - An infusion pump includes a main body; a tube attachment section, in which an infusion tube is attachable; a liquid feed driving unit disposed inside the main body; an access cover mounted on the main body and configured to cover the infusion tube when the infusion tube is attached to the tube attachment section when closed; and a bubble detection unit. The bubble detection unit includes a first member disposed at the access cover and a second member disposed at the main body. The infusion pump is configured such that, when the infusion tube is attached to the tube attachment section, a first space of the infusion tube is located between the first member and the second member of the bubble detection unit a second space of the infusion tube is located downstream of the first space, and the second space is smaller than the first space.2015-06-04
20150151058NEBULIZER APPARATUS COMPRISING A MESH2015-06-04
20150151059INHALER - An inhaler comprising a housing defining a chamber to receive a strip having a plurality of blisters each containing a dose of medicament for inhalation by a user is disclosed. It comprises an inhaler comprising a housing to receive a strip having a plurality of blisters, each blister having a puncturable lid and containing a dose of medicament for inhalation by a user, a mouthpiece mounted to the housing and through which a dose of medicament is inhaled by a user, a blister piercing member mounted for rotation about a first axis and an actuating mechanism including an actuating lever mounted for rotation about a second axis to sequentially move each blister into alignment with the blister piercing member, wherein the actuating lever co-operates with the blister piercing member so that the blister piercing member pivots about said first axis in response to rotation of the actuating member from an initial position about the second axis to puncture the lid of an aligned blister so an airflow through the blister is generated to en-train the dose contained therein and carry it, via the mouth-piece, into the users airway when a user inhales through the mouthpiece. The inhaler comprises an actuating lever load control member to control the force that must be applied to the actuating lever to cause it to rotate from its initial position such that a biasing force is applied to the actuating lever throughout all, or at least a substantial portion of, the stroke of the actuating lever.2015-06-04
20150151060OSCILLATING POSITIVE EXPIRATORY PRESSURE DEVICE - An oscillating positive expiratory pressure apparatus having a housing defining a chamber, a chamber inlet, a chamber outlet, a deformable restrictor member positioned in an exhalation flow path between the chamber inlet and the chamber outlet, and an oscillation member disposed within the chamber. The deformable restrictor member and the oscillation member are moveable between an engaged position, where the oscillation member is in contact with the deformable restrictor member and an disengaged position, where the oscillation member is not in contact with the deformable restrictor member. The deformable restrictor member and the oscillation member move from the engaged position to the disengaged position in response to a first exhalation pressure at the chamber inlet, and move from the disengaged position to an engaged position in response to a second exhalation pressure at the chamber inlet.2015-06-04
20150151061Modification of Sympathetic Activation and/or Respiratory Function - Devices, systems and methods are disclosed for modifying sympathetic activation of a patient through alteration of respiratory function. In one form, a sub-apneic ventilation target for a ventilator is determined such that chronic sympathetic activation of the patient is mitigated.2015-06-04
20150151062METHOD AND APPARATUS FOR RESOLVING UPPER AIRWAY OBSTRUCTION, RESISTANCE OR INSTABILITY - A CPAP apparatus has a variable rise time (iii) from a base level of positive air pressure during expiration (EPAP) to a higher level during inspiration (IPAP). The rise time is adjusted in order to reduce obstruction, resistance or instability in the upper airway.2015-06-04
20150151063SYSTEM AND METHODS FOR LUNG ISOLATION AND ONE LUNG VENTILATION - A lung isolation system configured for selective isolation and ventilation of the lung in conjunction with a standard endotracheal tube. The system includes an expandable bronchial isolation tube comprising a collapsible nitinol frame, a bifurcated adapter, and a steerable optical stylet.2015-06-04
20150151064PATIENT INTERFACE SYSTEM WITH ARTICULATING FOREHEAD PAD ATTACHMENT - A patient interface device (2015-06-04
20150151065MASK WITH GUSSET - A mask system for delivering air to a user includes a suspension mechanism to allow relative movement between a face-contacting cushion and a mask shell. The suspension mechanism also provides a predetermined force to the cushion that is a function of mask pressure, displacement of the cushion or both.2015-06-04
20150151066FACIAL MASK WITH CUSTOM-MANUFACTURED CUSHION ELEMENT, AND ASSOCIATED METHOD - Disclosed is a method of forming at least a portion of a mask (2015-06-04
20150151067SEALING CUSHION HAVING ANGLED SEALING FLAP - A cushion (2015-06-04
20150151068PATIENT INTERFACE DEVICE - The present invention relates to a patient interface device (2015-06-04
20150151069PATIENT INTERFACE - The invention provides a patient interface (2015-06-04
20150151070CLOSURE METHODS AND DEVICES FOR HEAD RESTRAINTS AND MASKS - A system for securing a mask about a user's face includes a mask that is configured to fit about the user's face, a padded member that is postionable on the back of the user's head, and at least one strap that extends from the padded member toward the mask. The system also includes a closure system that is coupled with the mask and with the strap. The closure system includes a tension member, a guide that routes the tension member about the mask and/or the strap, and a tensioning device that is operable to tension the tension member and thereby pull the strap and padded member toward the mask to secure and/or tighten the mask about the user's face.2015-06-04
20150151071NASAL MASK SYSTEM - A swivel elbow and connector assembly for a patient interface system includes a ring (2015-06-04
20150151072VENTILATION ANALYSIS AND MONITORING - A ventilation analysis system comprising an interface module adapted to receive a carbon dioxide (CO2015-06-04
20150151073Systems and methods for body temperature management - A system and method of body temperature regulation, including inhalation of cooled or warmed air flow supplied either manually or by a ventilator through an intubation tube or a breathing mask. The system is automatically regulated to produce a regime of compensated hyperventilation defined as the rate of breathing gas supply that would cause the defined decrease of CO2015-06-04
20150151074MEDICAL COMPONENTS WITH MICROSTRUCTURES FOR HUMIDIFICATION AND CONDENSATE MANAGEMENT - New medical circuit components and methods for forming such components are disclosed. These components include microstructures for humidification and/or condensate management. The disclosed microstructures can be incorporated into a variety of components, including tubes (e.g., inspiratory breathing tubes and expiratory breathing tubes and other tubing between various elements of a breathing circuit, such as ventilators, humidifiers, filters, water traps, sample lines, connectors, gas analyzers, and the like), Y-connectors, catheter mounts, humidifiers, and patient interfaces (e.g., masks for covering the nose and face, nasal masks, cannulas, nasal pillows, etc.), floats, probes, and sensors in a variety of medical circuits.2015-06-04
20150151075BREATHING ASSISTANCE APPARATUS - A pressure regulating device for use with a breathing assistance and/or resuscitation apparatus, which conveys gases along a gases pathway to a patient, includes a mounting for connecting the pressure regulating device to a first outlet in fluid communication with the gases pathway. The mounting holds a valve member that selectively blocks, at least in part, the first outlet. A control member can be manipulated to adjust a property of the valve member. The valve member at least partially blocks the first outlet when the pressure of gases in the pathway is below a selected level, and allows at least a portion of the gases to flow out of the first outlet when the pressure of said gases is above the selected level. The property includes a selected level of pressure whereby manipulation of the control member adjusts the level of pressure between a maximum level and a minimum level.2015-06-04
20150151076SOUND PILLOW SLEEP SYSTEM - Provided is a pillow and method of marking the pillow to mitigate tinnitus. The pillow includes a first and second portions of fill material, an anchor strip assembly and a pillow casing. The anchor strip assembly is disposed between the first and second portions of fill material. The anchor strip assembly includes an anchor strip and a plurality of speakers secured onto the anchor strip at a distance from each other. A first and second edge portions of the anchor strip extend beyond edges of the first and second portions of fill material. The pillow casing secures the anchor strip assembly disposed between the first and second portions of fill material inside the pillow casing such that the first and second edge portions of the anchor strip are secured respectively between a first and second seams of the pillow casing.2015-06-04
20150151077Devices And Methods For Renal Denervation - Devices and methods that produce alterations of renal sympathetic nerve activity by use of tissue modifying implants. Devices for percutaneous delivery of implants into a renal artery or vein wall employing various needle assembly arrangements to modify renal nerve activity.2015-06-04
20150151078Catheter - Novel catheters are disclosed herein having multiple body components operatively configured to slideably and sealably interact with one another.2015-06-04
20150151079METHOD OF CONTROLLABLY DIRECTING A DEVICE INTO A HUMAN VESSEL - A method of controllably directing an elongate device into a vessel network including the steps of: obtaining a tubular component with a tubular wall bounding a passageway and having an aperture between spaced ends; directing an introducing member into the vessel network towards a target site; placing the introducing member and tubular component in an operative relationship wherein at least a portion of the introducing member resides within the passageway; relatively repositioning the introducing member and tubular component by guided movement, one against the other, to place the aperture at an introduction location; and directing the device through the passageway to and through the aperture to the target site.2015-06-04
20150151080INSTRUMENT AND METHOD FOR MAKING THE SAME - A process for producing the actuating part of an instrument for endoscopic applications, which instrument comprises a tubular member having a handling end portion with a flexible portion and an actuating device located at another end portion, which actuating device comprises a cylindrical part connected to the handling end portion, a cylindrical part connected to the actuating device and a number of longitudinal elements for transferring the movement of the actuating device to the handling end portion, the actuating device being made beginning with a full cylindrical tube which is provided with a number of longitudinal slits thereby forming the longitudinal elements.2015-06-04
20150151081GUIDE WIRE CONTROL CATHETER FOR CROSSING OCCLUSIONS AND RELATED METHODS OF USE - A wire control catheter for aligning and guiding a guide wire through a lesion in a vessel is provided. The wire control catheter includes a shaft having a guide wire lumen and a control wire lumen. A control wire passes through the control wire lumen and is used in combination with an articulation structure to deflect or curve a distal tip portion of the catheter. The distal catheter shaft may include a centering device for centering the catheter within the vessel. The distal catheter shaft may also include a pre-dilation balloon for dilating the lesion prior to performing angioplasty or other treatment on the lesion. A method of treatment of a blood vessel includes inserting a guide wire into the blood vessel and advancing a control wire over the guide wire until the distal tip of the catheter is near the occlusion in the blood vessel. The tip of the catheter then is deflected via a control wire and an articulation structure. The guide wire is then advanced across the occlusion. The control wire also may be advanced across the occlusion simultaneously with the guide wire or subsequent to the guide wire crossing. Prior to crossing the occlusion, the wire control catheter may be centered using a centering device. Subsequent to crossing the occlusion, the occlusion may be pre-dilated with a pre-dilation balloon of the wire control catheter.2015-06-04
20150151082Cradle Including Optical Indication Device - A cradle and methods of using embodiments of the cradle are described. The cradle has a proximal side and a distal side, where the proximal side has a skin attachment member for releasable attachment to a patient's skin. The distal side includes a device attachment member configured to attach an initially separate medical device. The cradle comprises an electronically controlled optical indication device, the electronically controlled optical indication device being configured to provide optical indications to the patient when the cradle is attached to the patient's skin.2015-06-04
20150151083INTEGRATED VASCULAR DELIVERY SYSTEM - An integrated vascular delivery system having a frame configured to receive a catheter insertable in a patient to deliver fluid at an insertion site. The frame includes a first hub, a second hub, and a pair of flexible lateral members extending between the hubs and including a tubular lateral member. The system also includes a fluidic channel that fluidically communicates with the catheter, wherein the fluidic channel passes through the tubular lateral member and at least one of the hubs, and includes a fixed turnabout portion in which fluid flows in a direction different from that within the catheter. The first and second hubs provide anchoring points on the patient distributed around the insertion site and on opposite ends of the catheter, thereby anchoring the frame to the patient and stabilizing the catheter. A method is provided for using an integrated vascular delivery system.2015-06-04
20150151084CATHETER ASSEMBLY BLOOD CONTROL DEVICE AND RELATED METHODS - A catheter assembly includes a catheter adapter and an introducer needle. The introducer needle extends through the catheter adapter and through a catheter tube so as to assist placement of the catheter tube into a patient's blood vessel. Blood flashback into the catheter tube and/or catheter adapter through an aperture in a side of the needle indicates when the catheter tube is within the blood vessel. After the catheter tube is placed in the blood vessel, the introducer needle is withdrawn. A primary septum within the catheter adapter blocks blood flow in a proximal direction past the primary septum. A secondary septum proximal the primary septum is biased so as to enter into the aperture in the introducer needle and plug the aperture while the needle is being withdrawn, thus blocking blood flow through the aperture after the aperture is drawn through the primary septum.2015-06-04
20150151085SAFETY NEEDLE ASSEMBLIES AND RELATED METHODS - A safety needle assembly having a first hub attached to a flexible tube and a second hub attached to a needle projecting through the flexible tube. A needle guard is positioned in an interior cavity of the first hub. The needle guard has a proximal wall having an opening and two arms each with an end and wherein the two ends spaced from and biased toward the needle in a ready position. In a particular example, a support is located inside the cavity of the first hub and wherein the two ends of the two arms on the needle guard rest on the support in the ready position.2015-06-04
20150151086SAFETY NEEDLE DEVICES AND RELATED METHODS - A needle safety device is disclosed in which a needle guard has several biasing arms that are biased by the needle shaft in a ready to use position. But in a protective position, at least one of the biasing arms is no longer biased by the needle shaft and moves to block a distal opening of the needle guard. The needle has a change in profile for engaging an opening on a proximal wall in a protective position. The needle guard may be formed from a stamped metal sheet having a plurality of cuts or clits. A catheter hub with a catheter tube can further be added for a safety catheter assembly.2015-06-04
20150151087SHEATH FOR GASTROSTOMA, SHEATHED DILATOR, SHEATH FOR GASTROSTOMA WITH INSERTION AID, GASTROSTOMY CATHETER KIT, AND METHOD OF SPLITTING SHEATH FOR GASTROSTOMA - The present invention provides a sheath for gastrostoma (2015-06-04
20150151088CATHETER ASSEMBLY WITH REUSABLE VALVE - A catheter assembly includes a catheter hub having an elastomeric septum that divides the catheter hub into a distal chamber and a proximal chamber. The septum also includes at least one slit that is closed and sealed when the septum is in an at-rest state. A septum activator is proximal the septum. When an external force pushes the activator against the septum, the activator deforms the septum so as to break the seal and create a flow path through the septum. A portion of the septum activator can be collapsible when subjected to the outside force. When the outside force is removed, the collapsible portion springs back to its at-rest shape, helping to pull the activator out of deforming engagement with the septum so that the septum can reseal. The activator can also be spring-biased away from engagement with the septum so that when the outside force is removed, the spring urges the activator out of engagement with the septum. With the activator removed, the septum slit can reseal.2015-06-04
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