| 23rd week of 2009 patent applcation highlights part 38 |
| Patent application number | Title | Published |
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| 20090142708 | Optical fiber illuminator, method of fabricating optical fiber illuminator, and optical recording head and optical recording and reading apparatus having the optical fiber illuminator - Provided is an optical fiber illuminator used for recording and reading high density optical information according to a near field recording (NFR) scheme, a method of fabricating the optical fiber illuminator, and an optical recording head and recording apparatus having the optical fiber illuminator. The optical fiber illuminator includes: an optical fiber having a core upon which light is incident and a clad that surrounds the core, one end of the optical fiber having a mirror formed in an inclined manner; and a lens formed on an outer surface of the optical fiber for focusing light reflected by the mirror. The optical fiber illuminator has an improved optical arrangement for optical illumination and detection, it is easy to manufacture, its optical input is easy to control, and it can be readily provided in an array form. When an array type optical recording and reading apparatus having an optical recording head and multiple aperture probes adopts the optical fiber illuminator, the resulting simple arrangement and compact size enables size reduction of the overall apparatus, a signal to noise ratio is high, and high density optical information can be recorded and reproduced at an extremely high rate. | 2009-06-04 |
| 20090142709 | IMAGER WITH TUNED COLOR FILTER - An optimized color filter array is formed in, above or below one or more damascene layers. The color filter array includes filter regions which are configured to optimize the combined optical properties of the layers of the device to maximize the intensity of the particular wavelength of light incident to a respective underlying photodiode. | 2009-06-04 |
| 20090142710 | METHOD FOR PATTERNING A PHOTORESIST LAYER - The disclosed is a method for patterning a photoresist layer. An object is provided, a photoresist layer is formed on the object, and an ink pattern is printed on the photoresist layer. Shielded by the ink pattern, the photoresist is exposed and developed to be patterned. In addition, a layered material is optionally formed between the object and the photoresist layer. | 2009-06-04 |
| 20090142711 | METHOD OF FORMING MASK PATTERN - The present invention relates to a method of forming a mask pattern. According to the present invention, a negative photoresist layer is formed over a substrate. Some regions of the negative photoresist layer are exposed. The exposed negative photoresist layers are developed. A positive photoresist layer is formed over the substrate including negative tone working photoresist layers. The substrate is baked so that a hydrogen gas is diffused into the positive photoresist layers at boundary portions of the negative tone working photoresist layers. The positive photoresist layers into which the hydrogen gas is diffused are developed. | 2009-06-04 |
| 20090142712 | METHOD OF MANUFACTURING IMAGE FORMING ELEMENT, IMAGE FORMING ELEMENT, AND IMAGE FORMING APPARATUS HAVING THE SAME - A method of manufacturing an image forming element which can reduce a manufacturing time and a manufacturing cost with a simplified manufacturing process, an image forming element manufactured by the method, and an image forming apparatus having the same. The method includes preparing a cylindrical image drum having at least one slot formed along a lengthwise direction, arranging a control board having a plurality of terminals inside the image drum such that the plurality of terminals are located in the slot, forming a photosensitive resin layer on an outer circumference of the image drum, processing the photosensitive resin layer to form a plurality of installation recesses along a circumference of the image drum in correspondence to the plurality of terminals and a plurality of connection holes to expose the terminals through an area of each of the installation recesses, and forming a plurality of ring electrodes in the installation recesses to connect to the plurality of terminals through the connection holes. | 2009-06-04 |
| 20090142713 | SUBSTRATE PROCESSING SYSTEM AND SUBSTRATE PROCESSING METHOD - A substrate processing system is used for a light exposure apparatus which performs light exposure at least twice on each of substrates. The system includes a carrier block, and a process section configured to process each of substrates transferred from the carrier block one by one. The process section includes a first coating process section configured to perform a first coating process, a first developing process section configured to perform a first developing process, a second coating process section configured to perform a second coating process, and a second developing process section configured to perform a second developing process. The system further includes an interface block configured to transfer substrates between the process section and the light exposure apparatus, and a substrate transfer mechanism configured to transfer substrates among them. | 2009-06-04 |
| 20090142714 | METHOD FOR USING A TOPCOAT COMPOSITION - A method of forming an image on a photoresist. The method includes: forming a photoresist over a substrate; applying a topcoat composition, the topcoat composition comprising at least one fluorine-containing polymer and a casting solvent, onto the photoresist; removing the casting solvent of the topcoat composition resulting in the formation of a topcoat material over the photoresist; exposing the photoresist to radiation, the radiation changing a chemical composition of the regions of the photoresist exposed to the radiation, forming exposed and unexposed regions in the photoresist; and removing i) the topcoat material and ii) the exposed regions of the photoresist or the unexposed regions of the photoresist. | 2009-06-04 |
| 20090142715 | LAMINATED RESIST USED FOR IMMERSION LITHOGRAPHY - There is provided a laminated resist which is transparent in the case of exposure light of not less than 193 nm and can form a fine pattern having an intended form without defects with good reproducibility. The laminated resist has a photoresist layer (L | 2009-06-04 |
| 20090142716 | Combustion Apparatus - A combustion apparatus comprising: a device for mixing a fuel with an oxidant; a combustion chamber in which combustion of the fuel/oxidant mix takes place; a pre-chamber located between the device and the combustion chamber; and means for supplying a gas to the pre-chamber so as to form a film of gas on the interior surface of the pre-chamber so as to prevent a combustion flame from the combustion chamber attaching itself to this interior surface damaging the pre-chamber, the supply of gas to the pre-chamber being such that where the gas first reaches the interior surface of the pre-chamber it forms a substantially continuous film of gas over this interior surface. | 2009-06-04 |
| 20090142717 | Metering combustion control - Metering combustion control in a fired equipment is disclosed in which both the fuel flow rate and the combustion air flow rate are metered in a desired ratio corresponding to a master firing rate demand, and the master firing rate demand combustion air flow directed to the combustion air regulating element is trimmed in response to an error based correction adjustment determined from the respective values of the fuel flow meter and combustion air flow meter input signals to drive the ratio between the fuel flow rate and the combustion air flow rate toward the desired ratio for controlling the combustion in accordance with the master firing rate demand. | 2009-06-04 |
| 20090142718 | ARTIFICIAL ACETYLENE GAS CANDLE - An improved artificial candle having an exterior appearance of a traditional wax candle, but which provides illumination by means of producing and burning acetylene gas. | 2009-06-04 |
| 20090142719 | Venturi housing assembly and method - A venturi housing assembly having a horizontal wall that is cast as part of the venturi housing assembly. A plurality of gas/air release openings are cast into the horizontal wall that gradually provide a balanced mix of gas and air to one or more burner heads and release the gas and air mixture in order to provide an even heat pattern. | 2009-06-04 |
| 20090142720 | Water Heater and a Method of Operating Same - A water heater (10) including a tank (12), a burner (26) and a heated gas outlet duct (40). The tank (12) has a substantially central flue (14) having an outlet (24) substantially adjacent the top (20) of the tank (12). The tank (12) is adapted for mounting with the flue (14) substantially vertically. The burner (26) is located beneath the tank (12). The burner (26) has an air inlet (32) and a pilot flame and is adapted to a burn a fuel to discharge heated gases up through the flue (14). The heated gas outlet duct (40) is of substantially unrestricted cross-section and has an upper, first end (42) in gas communication with the flue outlet (24) and a second, lower end (46) in gas communication with atmosphere. When only the pilot flame is burning, the heated gas outlet duct (40) is adapted to restrict the air drawn into the flue (14) via the air inlet (32) to the minimum amount required to maintain the pilot flame alight. | 2009-06-04 |
| 20090142721 | Atmosphere Heat Treatment Apparatus and Method of Operating the Same - An object of the present invention is to provide an atmosphere heat treatment apparatus that is operable without relying on experiences and/or intuitions of an operator, and a method of operating the same. The atmosphere heat treatment apparatus includes an entrance side exhaust path ( | 2009-06-04 |
| 20090142722 | CERAMIC MULTILAYER COMPONENT, METHOD FOR THE PRODUCTION THEREOF, AND RETAINING DEVICE - A retaining device for use when sintering electrical components made of ceramic and metal electrodes inside the ceramic. The retaining device includes a structure to hold the electrical components. The structure has a surface that contains a sintering aid. The sintering aid includes a material that is able to bind to a gas contained in the structure and to release the gas. | 2009-06-04 |
| 20090142723 | ORTHODONTIC DEVICE - Orthodontic device for activating the growth of the lower jaw for use in combination with fixed orthodontic appliances, comprising two plastic bodies, each provided with at least one counter-surface corresponding to the chewing surface of molars in the upper jaw, and at least one counter-surface corresponding to the chewing surface of molars in the lower jaw, and further attaching means for attaching to the upper jaw, wherein each plastic body comprises at least two parts which can be displaced and fixed relative to each other substantially parallel to the longitudinal direction of the respective counter-surfaces, wherein each part is provided with at least one of said counter-surfaces. | 2009-06-04 |
| 20090142724 | ILLUMINATION SYSTEM FOR DENTISTRY APPLICATIONS - A dental illumination system includes an adjustable self-supporting frame and a lamp head coupled to the frame. The lamp head includes a housing and a spacer having formations that is adapted to removably mechanically couple the lamp head to a reference device, again having formations, for facilitating illumination of a tooth by a light source contained within the lamp head. The spacer and lamp head may be formed integrally. If formed separately, both the lamp head and the spacer may include formations. | 2009-06-04 |
| 20090142725 | DENTAL MATRIX BAND - A dental matrix band includes a body portion, having a fluoropolymer layer disposed thereon. The fluoropolymer layer reduces undesirable adhesion between dental restorative material and the matrix band. In one embodiment, the fluoropolymer is applied onto the body portion of a stainless steel matrix band in a layer having a thickness in the range of from approximately 0.0005 inches to 0.001 inches. | 2009-06-04 |
| 20090142726 | Radicular Spectral Attenuation Coefficient for Use in Endodontic Foraminal Locator - The discovery of a new coefficient named “Radicular Spectral Attenuation Coefficient-RSAC”, applicable in electronic foramen locators is described. The novelty is the use of the spectral attenuation of a multifrequency electrical current signal, applied through the endodontic file into the tooth canal (TC), to determine the root length and the foramen position. FIG. ( | 2009-06-04 |
| 20090142727 | DEVICE FOR DELIVERING MEDICINAL IMPLANTS - The invention includes a device for inserting a medicament within a body cavity of a mammal, the device including a cartridge for containing the medicament therein, the cartridge including a housing, a retractable chamber disposed within the housing and having a lumen, a substantially stationary member disposed within the lumen of the retractable chamber and having a uniform cross-section sized to provide a sliding fit within the lumen to provide for retraction of the retractable chamber about the substantially stationary member upon actuation of the device, and means for retracting the retractable chamber about the substantially stationary member while maintaining the substantially stationary member in a substantially stationary position upon actuation of the device; the device further including means for activating the means for retracting the retractable chamber. | 2009-06-04 |
| 20090142728 | ACTUATORS FOR DEVICE FOR DELIVERING MEDICINAL IMPLANTS - The invention includes an actuator for actuating a device for inserting a medicament within a body cavity of a mammal, the actuator including a handle case having a proximal portion for gripping and a distal portion including means for attaching the actuator to a cartridge for containing medicament, and means for creating a proximal to distal linear motion with respect to the handle case, wherein the cartridge includes a retractable chamber for containing the medicament disposed therein, a substantially stationary member and means for retracting the retractable chamber about the substantially stationary member while maintaining the substantially stationary member in a substantially stationary position. | 2009-06-04 |
| 20090142729 | Method and Releasably Connecting a Tool to a Dental Handpiece and Connection Between the Tool and Dental Handpiece - The invention relates to a method for establishing a releasable connection between a tool connection or coupling piece, which is formed on a dental handpiece, and the tool shank of a dental hand instrument. In order to connect a journal-like fastening section, which tapers toward a free end, on one of the elements to be connected, is inserted into an opening while matching the same, which is adapted to this section, on the other of the elements to be connected. | 2009-06-04 |
| 20090142730 | Device for holding a dental instrument - The invention relates to a device for holding a dental instrument in the head of a contra-angle, an instrument of the type comprising, in its upper part which is inserted into the head of the contra-angle, a lateral flat for rotating it and an annular groove for axially retaining it, characterized in that the shank receiving the handle of the instrument, comprises a transverse cutback ( | 2009-06-04 |
| 20090142731 | Reamer for Operating Implant - Provided is a reamer for operating an implant. The reamer includes a cutting blade for cutting a bone in order to place the implant in the bone, and a screw portion formed in a left-hand screw such that the cutting blade pushes upward bone remnants generated after the bone is cut or a transplanted bone transplanted in advance to a maxillary sinus mucous membrane while the reamer for operating the implant rotates counterclockwise. | 2009-06-04 |
| 20090142732 | Immediate-Load Dental Implants - The present invention relates to a medicinal device made of biocompatible ceramics and/or titanium comprising a threaded part ( | 2009-06-04 |
| 20090142733 | SUPPORT STRUCTURE FOR A PRINTED MODEL IN MULTI-COMPONENT DENTAL APPLIANCES - Dental appliances including multiple components and a system and method for constructing the same are disclosed herein. The dental components are designed to fit together to form the dental appliance. The components of the dental appliance are electronically modeled, printed, and pressed sequentially, separately, or as a unitary piece. Forming the dental appliance from multiple components enables each component of the dental appliance to be formed from a different material, each material having different features associated with it. In various embodiments, different materials have different colors, textures, opacities, and transformation factors associated with them. Furthermore, each component can be formed from multiple components. In some other embodiments, a support structure is designed and constructed in order to minimize deformation of a dental component during fabrication of the component. | 2009-06-04 |
| 20090142734 | Cosmetic accessory device for teeth - An improved cosmetic accessory device for teeth that simulates the appearance of an assemblage of teeth and gum. The device includes a gum portion and a tooth portion shaped and dimensioned to cover the user's upper or lower front teeth. The device is made of a nontoxic, nonirritating, tasteless, odorless, resilient, easily cleaned and chemically stable material that does not stick to natural teeth, gums, or most dental work. In use, the device is held in place by custom-fitted inner projections that match the spaces between the user's own front teeth. Optionally, a shelf extending just across the front teeth and extra fitting material placed in spaces where there are missing teeth provides additional security in holding the device in place. The device may be refitted as necessary by simply partially submerging the device in hot water. Unlike typical conventional novelty dental devices, the natural teeth and gums are not completely covered and there is no protrusion into the mouth cavity, so the device is comfortable to wear and does not interfere with natural speech or bite closure. | 2009-06-04 |
| 20090142735 | Bacterial intraoral disease treatment composition, washing treatment solution, hemostatic treatment solution, and bacterial intraoral disease treatment method - A treatment method is provided that is entirely different from conventional treatment methods in that it is capable of sufficiently suppressing pain and the recurrence of all the bacterial intraoral diseases without depending on removal of living tissues. This treatment method is a lesion-sterilizing and tissue-repairing treatment method including the processes of: washing teeth affected with bacterial intraoral disease with a washing treatment solution; administering a treatment composition to the washed teeth; and covering an opening of the teeth. This treatment composition includes an antibacterial agent having an antibacterial property against intraoral bacteria and a base containing polyethylene glycol 400, polyethylene glycol 600, polyethylene glycol 6000, and propylene glycol. | 2009-06-04 |
| 20090142736 | Goal Based System Utilizing a Table Based Architecture - A system is disclosed that provides a goal based learning system utilizing a rule based expert training system to provide a cognitive educational experience. The system provides the user with a simulated environment that presents a business opportunity to understand and solve optimally. Mistakes are noted and remedial educational material presented dynamically to build the necessary skills that a user requires for success in the business endeavor. The system utilizes an artificial intelligence engine driving individualized and dynamic feedback with synchronized video and graphics used to simulate real-world environment and interactions. A robust business model provides support for realistic activities and allows a user to experience real world consequences for their actions and decisions and entails realtime decision-making and synthesis of the educational material. The system is architectured around a table of components to manage and control the system. | 2009-06-04 |
| 20090142737 | Method and system for developing reading skills - A system and method for developing reading skills, the system comprising a processor and a reader interface in communication with one another. The processor is structured to run at least one computer program for facilitating interactive multimedia learning relating to the development of reading skills. The reader interface is structured to present multimedia content including a text-based passage to a reader, and to receive input from the reader. The reader interface is further structured to display animated text, and to permit placement of the animated text in a location that facilitates viewing thereof. The reader interface also comprises audio and graphic aids which correspond to the text-based passage. Additionally, the processor is structured to measure and track at least one reading performance indicator. | 2009-06-04 |
| 20090142738 | Music and math teaching system - A music and math teaching system teaches fraction computations utilizing musical note names and note values in the form of blocks with varying lengths while simultaneously teaching rhythmic topics of time signatures, beats, and tempo. A rhythm board is used to mount note blocks and beat blocks in the process and a blind is used to block the vision of a student working with the blocks. | 2009-06-04 |
| 20090142739 | LAPAROSCOPIC TRAINER AND METHOD OF TRAINING - A surgical training device for the practice of surgical techniques comprises a base and a face wall extending from a side of said base such to block direct visualisation of the operation area from the normal external position of the eyes of the trainee using the device. The face wall comprises a front wall and an upper wall. The front wall is extended upwardly from the base; the upper wall is then extended upwardly and inwardly from the front wall. A flexible membrane is stretched on upper wall and has at least two portals such that adaptors can be inserted on flexible membrane. The adaptors are further fitted with stoppers to prevent adaptors been pulled out from the membrane during training. The surgical instruments can pass through the openings of adaptors to manipulate simulated tissue or another operable structure on the base. A plain spherical bearing set, including a bearing seat and a plain spherical bearing, is also installed on said upper wall. The bearing seat has a bearing hole to interference fit with plain spherical hearing and two bolt holes to hold bearing seat on upper wall such that a camera handle can pass through plain spherical bearing to catch the image on base. | 2009-06-04 |
| 20090142740 | METHOD AND SYSTEM FOR INTERACTIVE PERCUTANEOUS PRE-OPERATION SURGICAL PLANNING - The success of percutaneous radiofrequency ablation mainly depends on the accuracy of the needle insertion, making it possible to destroy the whole tumor, while avoiding damages on other organs and minimizing risks of a local recurrence. This invention presents a simulated 3D environment for user to interactively place a treatment probe to a target position. | 2009-06-04 |
| 20090142741 | MEDICAL TRAINING METHODS AND DEVICES - The present subject matter relates to medical training methods and models. In one embodiment, the invention provides for devices and methods of training paracentesis procedures. In another embodiment, the subject matter provides for devices and methods of training thoracentesis procedures. In yet another embodiment, the present subject matter provides for a training methods and model for performing lumbar punctures. | 2009-06-04 |
| 20090142742 | Analysis for Assessing Test Taker Responses to Puzzle-Like Questions - Some embodiments of the invention provide computer-delivered curriculum content to a student. The curriculum of some embodiments includes learning interactions that are designed to give a student substantive feedback when the student provides a response to a “puzzle-like” question. Puzzle-like questions are questions that have a solution space with a relatively large number of potential responses (e.g., with more than one correct answer or partially correct answer or partially incorrect response or incorrect response). Some embodiments provide assessment analysis for the puzzle-like questions. When a test taker provides an incorrect response or a partially correct response, for example, some embodiments present to the test taker prestored feedback regarding the particular misunderstanding that is associated with the response in order to explain the possible misunderstanding. Some embodiments perform the assessment analysis for puzzle-like questions by using a rule-based technique to describe multiple acceptable responses (e.g., one or more completely correct answers and one or more partially correct answers). Rules can be specified to associate commentary to different possible responses. Some embodiments embed the rules in an XML format that is utilized at runtime. | 2009-06-04 |
| 20090142743 | SERVICE PROVIDING SYSTEM - There is provided a system which is able to realize study assistance or a desired appliance operation for a user, even in the absence of an answer input from the user. | 2009-06-04 |
| 20090142744 | Method for the Analysis of a Blood Sample, and Apparatus and Reagent for Its Implementation - Method for the automatic analysis of a blood sample in which: an analysis solution containing the blood sample, a diluent, and at least one compound to lyze the erythrocytes; at least one compound to stabilize the haemoglobin in the form of a chromogenic complex, is formed in a single dilution and analysis tank, the haemoglobin level is measured in this analysis solution by spectrophotometry in the tank after the lysis of the erythrocytes; and an appropriate quantity of this analysis solution is taken from the tank on which a leucocytic differentiation is carried out by an optical elements characterized in that the analysis solution also contains at least one compound to protect the leucocytes, allowing the distinguishing of at least four main leucocyte sub-populations. A haematological analysis apparatus for the implementation of such a method is disclosed. | 2009-06-04 |
| 20090142745 | INSTRUMENTS AND METHODS FOR EXPOSING A RECEPTACLE TO MULTIPLE THERMAL ZONES - A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle. | 2009-06-04 |
| 20090142746 | Pancreatic Cancer Genes - The present invention provides the art with the DNA coding sequences of polynucleotides that are up-or-down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dysplasia. Inhibitors of the up-regulated polynucleotides and proteins can decrease the abnormality of cancer and dysplasia. Enhancing the expression of down-regulated polynucleotides or introducing down-regulated proteins to cells can decrease the growth and/or abnormal characteristics of cancer and dysplasia. | 2009-06-04 |
| 20090142747 | Development of Diagnostic Kit for the Detection of Chrysanthemum Virus B - The present invention provides a method for detection of | 2009-06-04 |
| 20090142748 | MICROPOROUS MATERIALS, METHODS OF MAKING, USING, AND ARTICLES THEREOF - Described herein are methods for separating one or more analytes present in a fluid sample. The methods involve passing the fluid through or into a microporous material, wherein the analytes are localized near the surface of the microporous material. Additional processing steps such as hybridization and amplification can be performed once the analyte is localized. In one method, once the analyte is localized, the analyte can be detected, counted, and correlated in order to determine the concentration of the analyte in the sample. In another method, the localized analyte is destabilized to make the localized analyte more accessible for chemical manipulation. Modified microporous materials and composite materials are also disclosed that can be used in any of the methods and articles described herein. The composite is composed of a microporous material and a pigment, wherein the pigment is incorporated in the microporous material. The pigments alter the optical properties of the microporous material, which enhances the detection of analyte once it is localized. Methods for making pigmented composites are also disclosed. In a further aspect, various kits and articles such as filtration devices containing any of the microporous materials described herein are provided. | 2009-06-04 |
| 20090142749 | Assessment of disease risk by quantitative determination of epimutation in normal tissues - An assay for assessing the risk of disease in an individual, wherein said assay comprises the steps of isolating a population of cells from normal tissue of said individual, and quantitatively determining the frequency of epimutation of a particular gene in said population of cells, wherein the epimutation of said gene is associated with said disease and said gene is other than one that is subject to normal parent of origin-specific expression. Preferably, the epimutation is DNA methylation of a tumour suppressor gene such as hMLH1, hMSH2, APC 1A, APC 1B and p16. | 2009-06-04 |
| 20090142750 | Method of detecting and identifying gram-negative obligative anaerobic bacterium - There is provided a method of detecting potentially beer-spoiling obligatory anaerobic gram-negative bacteria, and a method of simultaneously detecting and distinguishing different beer-spoilage microorganisms including such bacteria. | 2009-06-04 |
| 20090142751 | ANALYZING POLYNUCLEOTIDE SEQUENCES - An apparatus is provided for analysing a polynucleotide. The apparatus includes: a support having an impermeable surface; porous material attached to the impermeable surface; and an array of oligonucleotides with predetermined sequences attached to the porous material. The array includes at least two defined cells, the sequence of the oligonucleotides of a first cell being different from the sequence of the oligonucleotides of a second cell, and the oligonucleotides being shorter than the polynucleotide. | 2009-06-04 |
| 20090142752 | Snap-Back Primers And Detectable Hairpin Structures - The present invention provides methods, compositions, and kits comprising snap-back primers used for forming 3′ hairpin structures, 5′ hairpin structures, and double hairpin structures. The hairpin structures may be used for detecting target sequences (e.g., such as small RNA target sequence), for detecting polymorphisms in target sequences (e.g., such as polymorphisms located near the 5′ or 3′ ends of the target sequence), or other nucleic acid characterization methods. In certain embodiments, the hairpin structures form invasive cleavage structures (e.g., in combination with a probe or upstream oligonucleotide) which may be cleaved by structure-specific enzymes in order to detect the presence or absence of a particular nucleotide or nucleotide sequence. | 2009-06-04 |
| 20090142753 | Compositions and methods for detecting compounds to treat a neurological disorder - The present invention generally provides compositions and methods that can be used to detect compounds that modulate the activity of at least one of the DJ-1, Parkin and Pink-1 genes. | 2009-06-04 |
| 20090142754 | RNA Detection Assays - The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5′ nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof. | 2009-06-04 |
| 20090142755 | ASSAY FOR DETECTING GENETIC ABNORMALITIES IN GENOMIC NUCLEIC ACIDS - The present invention provides methods of detecting unamplifed genomic nucleic acid anchored to a solid support. The methods are useful for the detecting genetic abnormalities associated with various diseases, diagnosis, and prognosis. | 2009-06-04 |
| 20090142756 | PREDICTION OF BARE METAL STENT RESTENOSIS - Methods for predicting whether or not a patient is likely to experience restenosis after the placement of a bare metal stent are provided. The methods involve detecting and analyzing gene expression patterns of the cellular components of whole blood, where activation of selected genes has been found to be indicative of a high probability of restenosis. The method thus allows the identification, prior to placement of a stent, of patients who are i) likely to experience restenosis, and thus should receive a stent that includes anti-restenosis agents; or ii) unlikely to experience restenosis, and thus should receive a stent without anti-stenosis agents. | 2009-06-04 |
| 20090142757 | STRIP AND METHOD FOR DETECTING NUCLEOTIDE AMPLIFICATION PRODUCTS OF MYCOBACTERIUM TUBERCULOSIS AND NON-TUBERCULOUS MYCOBACTERIUM - The present invention provides a test strip and a method for rapid identifying the presence of the amplified DNA product of | 2009-06-04 |
| 20090142758 | STRATEGIES FOR SEQUENCING COMPLEX GENOMES USING HIGH THROUGHPUT SEQUENCING TECHNOLOGIES - A method for determining a genome sequence comprising the steps of digesting the genome with at least one first restriction endonuclease, ligating at least one adaptor to the restriction fragments of the first subset, selectively amplifying the first set of adaptor-ligated restriction fragments using a first primer combination wherein at least a first primer contains a first selected sequence at the 3′ end of the primer sequence, comprising 1-10 selective nucleotides, repeating these steps with at least a second primer combinations wherein the primer contains a different second selected sequence, fragmenting each of the subsets of amplified adaptor-ligated restriction fragments to generate sequencing libraries, determine the nucleotide sequence of the fragments, aligning the sequence of the fragments in each of the libraries to generate contigs, repeating these steps for one second and/or further restriction endonucleases, aligning the contigs obtained for each of the second and/or further restriction endonucleases to provide for a sequence of the genome. | 2009-06-04 |
| 20090142759 | qPCR array with IN SITU primer synthesis - Application of in situ oligonucleotide synthesis, using a maskless photolithographic oligonucleotide synthesis apparatus or by other means, for direct fabrication of polymerase chain reaction (PCR) primers in situ in PCR reaction wells. The synthesized oligonucleotides contain an enzymatically degradable linker sequence and a specific primer sequence. The method may be used for manufacturing of quantitative PCR (qPCR) arrays containing a plurality of independent qPCR assays while eliminating the need for presynthesized primer libraries. | 2009-06-04 |
| 20090142760 | Nucleic Acid Sequences Associated with Cell States - The present invention is directed to nucleic acid sequences whose expression is associated with different cell states, including nucleic acid sequences whose expression is induced at least 100-fold, or alternatively upregulated, in cells exhibiting asymmetric self-renewal relative to other cells. The invention is also directed to nucleic acid sequences whose expression is induced at least 100-fold, or alternatively upregulated, in cells exhibiting symmetric self-renewal relative to other cells. | 2009-06-04 |
| 20090142761 | METHODS AND KITS FOR METHYLATION DETECTION - Ligation-based methods and kits are disclosed for determining the degree of methylation of one or more target nucleotides. In certain embodiments, the methylation status of one or more target nucleotides is determined by generating misligation products. In certain embodiments, at least one target nucleotide is amplified prior to the ligation reaction. In certain embodiments, at least one ligation product, at least one ligation product surrogate, at least one misligation product, at least one misligation product surrogate, or combinations thereof are amplified. In certain embodiments, one or more ligation probes comprise at least one nucleotide analog, at least one Modification, at least one mismatched nucleotide, or combinations thereof. | 2009-06-04 |
| 20090142762 | Method of Screening for Binding Interaction Using Sets of Microparticles and Unique Probes - The present invention relates to methods for screening for binding interactions using multiple sets of microparticles, wherein said set has the same identifiable characteristic and wherein one of more sets comprise subsets of microparticles and said subset presents at least one unique probe that acts as a binding partner for a target molecule in a biological sample. In particular, the invention provides for methods of detecting tissue-typing antigens in donor tissue or recipient tissue using these multiple sets of microparticles. | 2009-06-04 |
| 20090142763 | NESTED PCR-BASED METHOD FOR SPECIFIC GENOTYPING OF THE FC GAMMA RECEPTOR IIIA GENE - The application describes a novel method for detection of a single nucleotide polymorphism, e.g., the 158 F/V polymorphism, in the FcγRIIIa gene using nested PCR to amplify large gene amplicons to aid in, e.g., genotyping applications. Thus, based on the results obtained in FcγRIIIa genotyping analysis, the present invention provides specific, efficient, reproducible, and accurate detection of such polymorphisms in genomic DNA. | 2009-06-04 |
| 20090142764 | Methods and Kits for Multiplex Amplification of Short Tandem Repeat Loci - Methods and materials are disclosed for use in simultaneously amplifying at least 11 specific STR loci of genomic DNA in a single multiplex reaction, as are methods and materials for use in the analysis of the products of such reactions. Included in the present invention are materials and methods for the simultaneous amplification of 16 specific loci in a single multiplex reaction, comprising the 10 AmpFISTR® SGMplus® STR loci, the Amelogenin locus, and 5 new STR loci, including methods and materials for the analysis of these loci. | 2009-06-04 |
| 20090142765 | METHOD AND APPARATUS FOR RAPIDLY COUNTING AND IDENTIFYING BIOLOGICAL PARTICLES IN A FLOW STREAM - A method for increasing the throughput, or the precision, or both the precision and the throughput, of a flow cytometer, or of a hematology analyzer employing a flow cytometer, and for further reducing the complexity of such a cytometer or analyzer, by utilizing the technique of laser rastering in combination with a lysis-free single-dilution method. Laser rastering involves sweeping a laser beam across a flowing sample stream in a hematology analyzer. A lysis-free single-dilution method involves performing all the flow cytometer measurements on a sample using a single aliquot, a single lysis-free reagent solution, a single dilution, and a single pass of said dilution through the measurement apparatus. An apparatus suitable for carrying out the method of this invention comprises an optical module comprising a source of light, a scanning device, a lens or system of lenses, a flowcell, detectors, and filters; and an electronic module comprising preamplifiers, analog signal conditioning elements, analog-to-digital converters, field-programmable gate arrays, digital signal processing elements, and data storage elements. | 2009-06-04 |
| 20090142766 | METHODS FOR MEASURING THE METABOLISM OF CNS DERIVED BIOMOLECULES IN VIVO - The present invention provides methods for measuring the metabolism of a central nervous system derived biomolecule implicated in a neurological and neurodegenerative disease or disorder. In particular, the method comprises measuring the in vivo metabolism of the biomolecule in the central nervous system of a subject. Also provided is a method for determining whether a therapeutic agent affects the in vivo metabolism of a central nervous system derived biomolecule. | 2009-06-04 |
| 20090142767 | Method for nucleic acid quantitation - It is intended to provide a novel convenient approach for DNA quantitative analysis that overcomes the disadvantages of conventional formulations. A standard DNA sample is prepared by introducing a single-base substitution into target DNA, and a predetermined amount thereof is mixed with a target DNA sample. The target and standard DNAs are amplified using the same primers designed to amplify a region comprising the single-base substitution site. To a hybridization product of a probe capable of binding to a site immediately before the single-base substitution site, ddATP, ddGTP, ddCTP, and ddTTP are sequentially added one by one to perform a complementary strand synthesis reaction. Luciferase reaction-induced luminescence derived from the formed pyrophosphoric acid is detected. The target DNA is quantitated from the amount of the detected luminescence and the amount of the added standard DNA sample. | 2009-06-04 |
| 20090142768 | PERFORIN-2 PROTEINS - Perforin-2 (P2) molecule is a pore forming protein. The 5′ untranslated region of the perforin-2 protein controls translational activity. Compositions include the perforin protein and the 5′ untranslated region. Methods of use include high-throughput screening assays for identification of therapeutic compounds in treatment of diseases. | 2009-06-04 |
| 20090142769 | Methods for determining anti-TNF therapeutic response - The present invention relates to methods for identifying patients that will respond to treatment with anti-TNF-therapy, i.e., anti-TNF responder patients. In particular, the present invention relates to determining response to an inhibitor of tumor necrosis factor (TNF) in a patient with a chronic inflammatory disease by determining the activity of type I interferon in the patient. The invention further relates to quantification of type I interferon as a measure of predicting responsiveness to anti-TNF therapy in patients with a chronic inflammatory disease such as rheumatoid arthritis (RA), psoriatic arthritis, ankylosing spondylitis, juvenile chronic arthritis, lupus, Crohn's disease, as well as for cardiovascular disease. | 2009-06-04 |
| 20090142770 | Hair Follicle Pharmacodynamic Assay for Telomerase Activity - The invention is directed to methods for determining the efficacy of treatment with telomerase modulators in mammals by the analysis of the level of telomerase reverse transcriptase activity in mammalian hair follicle cells. | 2009-06-04 |
| 20090142771 | Methods and Instruments for Processing a Sample in a Multi-Chambered Receptacle - A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle. | 2009-06-04 |
| 20090142772 | Devices and Methods for the Detection of Analytes - System and methods for detecting analytes such as pathogenic cells are described. The methods allow for the direct measurement of analytes such as pathogenic organisms without the need for sample preparation and/or PCR. The devices can be used individually as point-of-use sensors for airborne pathogens and other pathogenic organisms in foods and agriculture products. | 2009-06-04 |
| 20090142773 | METHODS AND CONTROLS FOR MONITORING ASSAY QUALITY AND ACCURACY IN PARATHYROID HORMONE MEASUREMENT - The present invention relates to the use of control compositions and kits comprising such to evaluate and monitor the consistency of assays utilized to determine parathyroid hormone levels. | 2009-06-04 |
| 20090142774 | METHOD FOR THE EARLY DETECTION OF RENAL INJURY - A method and kit for detecting the immediate or early onset of renal disease and injury, including renal tubular cell injury, utilizing NGAL as an immediate or early on-set biomarker in a sample of blood serum. NGAL is a small secreted polypeptide that is protease resistant and consequently readily detected in the blood serum following renal tubule cell injury. NGAL protein expression is detected predominantly in proximal tubule cells, in a punctuate cytoplasmic distribution reminiscent of a secreted protein. The appearance NGAL in the serum is related to the dose and duration of renal ischemia and nephrotoxemia, and is diagnostic of renal tubule cell injury and renal failure. NGAL detection is also a useful marker for monitoring the nephrotoxic side effects of drugs or other therapeutic agents. | 2009-06-04 |
| 20090142775 | Methods For Separating Organelles - Methods and kits for separating organelles of a specific type from a mixture of organelles of different types are described. The methods comprise providing a mixture of organelles of different types, adding probes to the mixture to form an organelle-probe complex with a distinct diffusion coefficient, and separating the organelles of the specific type from the mixture of organelles based upon the diffusion coefficient of the complex. The probes used in these methods include an affinity portion which binds selectively to the organelle of the specific type and a tag portion which imparts the distinct diffusion coefficient to the complex. | 2009-06-04 |
| 20090142776 | ANTIBODY FOR ASSAYING ADAMTS13 ACTIVITY AND METHOD FOR ASSAYING THE ACTIVITY - The subject of the present invention is to provide a useful antibody for measuring ADAMTS13 activity, in particular, a monoclonal antibody and a method for measuring ADAMTS13 activity. Further, another subject of the present invention also is to provide a monoclonal antibody which has specific reactivity to an antigenic determinant site produced by reacting ADAMTS13 with VWF that is a substrate or a partial peptide of VWF that is a potential substrate, but has no specific reactivity to the complete VWF molecule, and a use of the antibody of interest. Those subjects were achieved by succeeding in obtaining a monoclonal antibody (anti-N-10 monoclonal antibody) which has specific reactivity to a cleavage site that is cleavable by ADAMTS13 in the partial peptide of VWF, and further by finding a method for measuring ADAMTS13 activity using the monoclonal antibody of interest. | 2009-06-04 |
| 20090142777 | Reagents for the detection of protein phosphorylation in leukemia signaling pathways - The invention discloses 424 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human Leukemia, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Adaptor/Scaffold proteins, Cytoskeletal proteins, Cellular Metabolism enzymes, G Protein/GTPase Activating/Guanine Nucleotide Exchange Factor proteins, Immunoglobulin Superfamily proteins, Inhibitor proteins, Lipid Kinases, Nuclear DNA Repair/RNA Binding/Transcription proteins, Serine/Threonine Protein Kinases, Tyrosine Kinases, Protein Phosphatases, and Translation/Transporter proteins. | 2009-06-04 |
| 20090142778 | COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF INFLAMMATORY BOWEL DISEASE - Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of IBD. | 2009-06-04 |
| 20090142779 | METHODS AND KITS FOR MEASURING VON WILLEBRAND FACTOR - Methods and kits for measuring levels of von Willebrand factor function in a sample without using a platelet aggregation agonist, such as ristocetin, comprising recombinant glycoprotein Ibα having at least two of a G233V, D235Y and M239V mutations and an agent to detect a complex between the recombinant glycoprotein Ibα and von Willebrand factor. | 2009-06-04 |
| 20090142780 | METHODS OF DONOR SPECIFIC CROSSMATCHING - The detection of endothelial cell antibodies has been proven clinically important for successful organ transplantation. Disclosed are methods of isolating endothelial cell antibodies and methods for donor-specific crossmatching. | 2009-06-04 |
| 20090142781 | Non-Liquid Phase Type Chemiluminescent Enzyme Immunoassay Method and Assay Kit - A chemiluminescent enzyme immunoassay method whereby a target substance such as a protein is assayed. This chemiluminescent enzyme immunoassay method comprises: the step of capturing an immune complex containing an enzyme-labeled antibody, which is labeled with an enzyme acting a chemiluminescent substrate, and the target substance on a support having no solution layer; the step of overlaying a support membrane containing the chemiluminescent substrate on the immune complex having been captured above; and the step of measuring the luminescence dose caused by the reaction between the enzyme-labeled antibody and the chemiluminescent substrate to thereby quantify the target substance. Since a highly sensitive chemiluminescent enzyme immunoassay is conducted by using a non-liquid phase type reaction system in the chemiluminescent enzyme immunoassay method as described above, multiple items can be assayed by using only a small amount of a specimen and, furthermore, the target substance can be assayed at a high sensitivity thereby without resorting to any troublesome procedures such as pipetting a reagent. | 2009-06-04 |
| 20090142782 | Identification of Actinobacillus actinomycetemcomitans Antigens for Use in the Diagnosis, Treatment, and Monitoring of Periodontal Diseases - Antibodies, polypeptides, and polynucleotides are provided for the detection, prevention, amelioration and treatment of diseases caused by | 2009-06-04 |
| 20090142783 | Human p51 Genes and Gene Products Thereof - Novel human genes falling within the category of family genes relating to p53 gene which is known as a cell proliferation regulatory gene, and gene products thereof. A human p51 gene characterized by containing a base sequence encoding an amino acid sequence represented by SEQ ID NO:1; a human p51 gene having a base sequence consisting of the 145- to 1488-bases in the sequence represented by SEQ ID NO:2; vectors containing these genes; host cells transformed with these vectors; a process for producing a p51 protein having the amino sequence represented by SEQ ID NO:1; which comprises culturing the above host cells and harvesting the protein from the thus obtained culture; and the p51 protein having the amino acid sequence represented by SEQ ID NO:1. | 2009-06-04 |
| 20090142784 | METHODS - A method for identifying a compound expected to be useful in modulating a LRRK2 protein kinase activity, the method comprising the steps of (1) determining whether a test compound modulates the protein kinase activity of a LRRK2 polypeptide on a substrate Ezrin/Radixin/moesin (ERM) family polypeptide and (2) selecting a compound which modulates the LRRK2 polypeptide protein kinase activity. Such a compound may be useful in treating Parkinson's Disease or Parkinsonism. A catalytically active fragment of LRRK2 is identified, requiring the GTPase, COR and kinase domains as well as the WD_40-like motif and C-terminal tail. | 2009-06-04 |
| 20090142785 | Capturing carrier, capturing device, analysis system using the same, and method for capturing and testing microorganisms - In order to make a process of capturing and testing air-borne microorganisms more convenient and quick, a capturing device which comprises the capturing carrier comprising a polymer which is in a gel phase at the time of capturing the microorganisms but undergoes a phase transition under heating to a sol phase at the temperature at or less than 40° C. (especially in the temperature range between 15° C. and 37° C.), and a vessel to contain the capturing carrier is used. Further, by comprising a test reagent in the polymer, the test reagent can be eluted upon said phase transition from a gel phase to a sol phase. By heating the capturing carrier, a phase transition to a sol phase can occur at or less than 40° C. As such, since recovery of microorganisms and addition of a test reagent to the microorganisms can be carried out simultaneously, the process can be simplified and the process time can be shortened. | 2009-06-04 |
| 20090142786 | SECRETED AND TRANSMEMBRANE POLYPEPTIDES AND NUCLEIC ACIDS ENCODING THE SAME - The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. | 2009-06-04 |
| 20090142787 | Albumin Denaturing Agent - An albumin denaturing agent for digesting an albumin by a protease efficiently is provided. The albumin denaturing agent contains quaternary ammonium having a hydrocarbon group with a carbon number of 12 or more, or a salt of the quaternary ammonium. The albumin in a sample is digested by the protease in the presence of the albumin denaturing agent, a glycated part of the thus obtained albumin digestion product and a FAOD effect a reaction, and a redox reaction between the glycated part and the FAOD is measured, thereby determining a ratio (GA (%)) of the glycated albumin of the glycated albumin with respect to the albumin. | 2009-06-04 |
| 20090142788 | SCREENING METHOD USING NEW SUBSTRATE EPHA4 OF GAMMA-SECRETASE - The present invention provides a method of screening for compounds which affect the processing of EphA4 by γ-secretase, comprising the following steps:
| 2009-06-04 |
| 20090142789 | Surface Preparation Method - A method of covalently immobilising a charged chemical species on or near a sensor surface of a mass-sensitive chemical sensor, the sensor surface bearing functional groups capable of forming covalent bonds with the chemical species, the method involving the application of an electric field between the charged chemical species and the sensor surface such that the electrostatic attraction therebetween is increased. | 2009-06-04 |
| 20090142790 | Label Free Biosensors and Cells - Disclosed are compositions and methods for using label free optical biosensors for performing cell assays. In certain embodiments the assays can be performed in high throughput methods and can be multiplexed. | 2009-06-04 |
| 20090142791 | Method and Apparatus for Detecting an Analyte - Embodiments of the present technique facilitate the detection of analytes. Detection is generally achieved by binding agents labeled with non-radiative energy transfer acceptors. The binding agents, when bound to a specific analyte, change conformation such that the distance between the respective non-radiative energy transfer acceptors and a respective quantum dot or quantum well changes. Certain embodiments of the present technique also comprise readout circuitry configured to determine rates of non-radiative energy transfer electrically and not optically. | 2009-06-04 |
| 20090142792 | Biomarkers for the diagnosis of autoimmune disease - Compositions and methods are provided for prognostic classification of autoimmune disease patients into subtypes, which subtypes are informative of the patient's probability of developing clinical symptoms or severe disease. The patterns of circulating blood levels of serum cytokines provides for a signature pattern that can discriminate patients that have a high probability of developing disease from those that have a low probability of developing disease. Assessment of this signature pattern in a patient thus allows improved methods of care and intervention. In one embodiment of the invention, the autoimmune disease is rheumatoid arthritis. | 2009-06-04 |
| 20090142793 | SCREENING ASSAY TO IDENTIFY MODULATORS OF THE SLEEP/WAKE CYCLE - Screening assays for identifying agents that modulate BK channel activity and further modulate the sleep/wake cycle in a subject, circadian regulated locomotor activity in a subject, or both are provided, as are agents identified using such screening assays. Also provided are methods of modulating the sleep/wake cycle in a subject and methods of modulating circadian regulated locomotor activity in a subject by administering an agent that modulates BK channel activity to the subject, for example, an agent identified by a screening assay as disclosed. | 2009-06-04 |
| 20090142794 | Mutated anthrax toxin protective antigen proteins that specifically target cells containing high amounts of cell-surface metalloproteinases or plasminogen activator receptors - The present invention provides methods of specifically targeting compounds to cells overexpressing matrix metalloproteinases, plasminogen activators, or plasminogen activator receptors, by administering a compound and a mutant protective antigen protein comprising a matrix metalloproteinase or a plasminogen activator-recognized cleavage site in place of the native protective antigen furin-recognized cleavage site, wherein the mutant protective antigen is cleaved by a matrix metalloproteinase or a plasminogen activator overexpressed by the cell, thereby translocating into the cell a compound comprising a lethal factor polypeptide comprising a protective antigen binding site. | 2009-06-04 |
| 20090142796 | Detection of Inducible Resistance to Macrolide-Lincosamide-Streptogramin b - The embodiments of this invention provide a test panel and method for the detection of inducible resistance to macrolide-lincosamide-streptogramin b (iMLSb) in microorganisms in an automated microorganism identification (ID) and antimicrobial susceptibility determinations (AST) system. | 2009-06-04 |
| 20090142797 | BLOOD DILUENT AND METHOD OF USE THEREOF - Blood diluent for use in the analysis of blood components may include at least one purine compound or salt thereof. The blood diluent may also include at least one of alkali metal salt and/or at least one organic buffers and/or inorganic buffer. The blood diluent may be utilized to stabilize blood cells during storage and facilitate the analysis thereof. | 2009-06-04 |
| 20090142798 | METHOD OF SELECTIVELY LYSING NON-VIABLE CELLS IN CELL POPULATION IN SAMPLE - The present invention provides a method of selectively lysing non-viable cells from a cell population within a sample, the method including selectively lysing non-viable cells by mixing a cell-containing sample with a lysis buffer including a non-ionic surfactant and a divalent cation salt. | 2009-06-04 |
| 20090142799 | METHOD FOR QUANTITATION OF COLLAGEN IN TISSUE - For successful wound healing to occur, the newly formed skin must generate tensile strength through collagen deposition. Measurement of collagen in the granulating wound bed may be predictive of successful wound healing. Existing methods for collagen measurement either require specialized equipment, or do not allow for discrimination of potential interfering molecules. Herein described is an accurate, specific and reliable method to extract and quantify collagen from tissue utilizing high pressure liquid chromatography techniques. The method is sensitive enough to measure the small amounts of collagen found in newly healing wounds. | 2009-06-04 |
| 20090142800 | Secreted and transmembrane polypeptides and nucleic acids encoding the same - The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. | 2009-06-04 |
| 20090142801 | BTL-II NUCLEIC ACIDS - The invention provides isolated BTL-II proteins, nucleic acids, antibodies, antagonists, and agonists and methods of making and using the same. Diagnostic, screening, and therapeutic methods using the compositions of the invention are provided. For example, the compositions of the invention can be used for diagnosis and treatment of inflammatory bowel diseases and for enhancing a mucosal immune response to an antigen. | 2009-06-04 |
| 20090142802 | POLYPEPTIDES AND NUCLEIC ACIDS ENCODING SAME - The present invention relates to isolated polypeptides and isolated nucleic acid sequences encoding the polypeptides, as well as methods for producing and using the polypeptides in animal feed. An example of a polypeptide of the invention is the so-called L12 protein from | 2009-06-04 |
| 20090142803 | Amylolytic Enzyme Variants - The inventors have discovered some striking, and not previously predicted structural similarities and differences between the structure of Novamyl and the reported structures of CGTases, and based on this they have constructed variants of maltogenic alpha-amylase having CGTase activity and variants of CGTase having maltogenic alpha-amylase activity. Further, on the basis of sequence homology between Novamyl® and CGTases, the inventors have constructed hybrid enzymes with one or more improvements to specific properties of the parent enzymes, using recombinant DNA methodology. | 2009-06-04 |
| 20090142804 | Process For Preparing Serine-Rich Protein Employing Cysteine Synthase (CYSK) Gene - The present invention relates to a process for preparing a serine-rich foreign protein comprising culturing a bacterium containing the cysteine synthase (cysK) gene and a gene encoding the serine-rich foreign protein. The present invention comprises the steps of culturing a bacterium transformed with an expression vector containing a gene encoding a serine-rich foreign protein and an expression vector containing the cysK gene, or a bacterium transformed with an expression vector containing the cysK gene and a gene encoding a serine-rich foreign protein and isolating the foreign protein therefrom. The present invention is expected to be widely used to increase the production yield of a serine-rich foreign protein. | 2009-06-04 |
| 20090142805 | High expression cell line that eliminates gene amplification - The present invention relates to methods, cell lines and kits for producing high titers of recombinant proteins without the need for gene amplification. | 2009-06-04 |
| 20090142806 | INTERLEUKIN-17F ANTIBODIES AND OTHER IL-17F SIGNALING ANTAGONISTS AND USES THEREFOR - The present invention provides isolated and purified polynucleotides and polypeptides related to the IL-17F signaling pathway. The invention also provides antibodies to IL-17F homodimers and IL-17A/IL-17F heterodimers, and methods of isolating and purifying members of the IL-17 family, including IL-17A/IL-17F heterodimers, from a natural source. The present invention also is directed to novel methods for diagnosing, prognosing, monitoring the progress of, and treating and/or preventing disorders related to IL-17F signaling, i.e., IL-17F-associated disorders, including, but not limited to, inflammatory disorders, such as autoimmune diseases (e.g., arthritis (including rheumatoid arthritis), psoriasis, systemic lupus erythematosus, and multiple sclerosis), respiratory diseases (e.g., COPD, cystic fibrosis, asthma, allergy), transplant rejection (including solid organ transplant rejection), and inflammatory bowel diseases or disorders (IBDs, e.g., ulcerative colitis, Crohn's disease). The present invention is further directed to novel therapeutics and therapeutic targets, and to methods of screening and assessing test compounds for the intervention (treatment) and prevention of disorders related to IL-17F signaling. | 2009-06-04 |
| 20090142807 | FUSION PARTNER FOR PRODUCTION OF MONOCLONAL RABBIT ANTIBODIES - The invention provides a rabbit-derived immortal B-lymphocyte capable of fusion with a rabbit splenocyte to produce a hybrid cell that produces an antibody. The immortal B-lymphocyte does not detectably express endogenous immunoglobulin heavy chain and may contain, in certain embodiments, an altered immunoglobulin heavy chain-encoding gene. A hybridoma resulting from fusion between the subject immortal B-lymphocyte and a rabbit antibody-producing cell is provided, as is a method of using that hybridoma to produce an antibody. The subject invention finds use in a variety of different diagnostic, therapeutic and research applications. | 2009-06-04 |
| 20090142808 | NOVEL ENZYME WITH FRUCTOFURANOSIDASE ACTIVITY, WHICH IS USED TO OBTAIN PREBIOTIC OLIGOSACCHARIDES - The invention relates to a method of obtaining industrially-viable prebiotic oligosaccharides, using a novel extracellular enzyme (fructofuranosidase) of | 2009-06-04 |
