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22nd week of 2011 patent applcation highlights part 43
Patent application numberTitlePublished
20110130542METHOD FOR THE SELECTIVE SEPARATION OF PEPTIDES AND PROTEINS BY MEANS OF A CRYSTALLIZATION PROCESS - Method for removing and selective separating peptides and proteins from a solution by controlled crystallization.2011-06-02
20110130543CHOLESTEROL CONSENSUS MOTIF OF MEMBRANE PROTEINS - The invention provides the structure of a human β2-adrenergic receptor, a cholesterol consensus motif, and methods of identifying modulators of G-protein coupled receptors (GPCRs). Methods of using the modulators of the receptor, GPCRs, and the cholesterol consensus motif are also provided.2011-06-02
20110130544ANTIBODIES WITH DECREASED DEAMIDATION PROFILES - The present invention relates to antibodies with decreased deamidation profiles, and methods for producing antibodies with decreased deamidation profiles.2011-06-02
20110130545PROCESS FOR PRODUCING MILK FRACTIONS RICH IN SECRETORY IMMUNOGLOBULINS - The present invention concerns a process for producing compositions that are rich in secretory IgA (S-IgA) by fractionating milk containing S-IgA. Such compositions may be used in particular for treating and/or preventing infections and/or inflammation of the mucosal surfaces, e.g. the gastro-intestinal tract, urogenital tract, respiratory tract, nasal cavity or oral cavity, treating and/or preventing obesity and related diseases, or treating and/or preventing food allergies in subjects in need of such treatment. Briefly stated, the current invention provides a process for producing milk fractions rich in secretory Immunoglobulin A, using one or more microporous membrane filtration steps. A preferred protocol of the present process involves de-fatting, micro-filtration and ultrafiltration-concentration through a number of diafiltration cycles. The process of the invention, apart from the unexpectedly high yields achievable, offers advantages which are of particular interest in view of the scalability, application in existing diary factories and controllability of process parameters influencing the S-IgA quality and stability.2011-06-02
20110130546IMMUNOSUPPRESSIVE POLYPEPTIDES AND NUCLEIC ACIDS - The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.2011-06-02
20110130547Reagents For The Detection Of Protein Phosphorylation In EGFR Signaling Pathways - The invention discloses 168 novel phosphorylation sites identified in signal transduction proteins and pathways downstream of, and including, EGFR kinase, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Actin Binding proteins, Adaptor/Scaffold proteins, Calcium-Binding Proteins, Cell Cycle Regulation proteins, Cytoskeletal proteins, DNA Binding and Replication Proteins, GTPase Activating proteins, Guanine Nucleotide Exchange Factor proteins, Lipid Kinases, Receptor Tyrosine Kinases, Receptor Tyrosine Kinase ligands, Protein Kinases, Receptor and Protein Phosphatases, Transcription Factor proteins, Tumor Suppressor proteins, and Vesicle proteins.2011-06-02
20110130548ANTI-HUMAN IL-21 MONOCLONAL ANTIBODIES - Human anti-human IL-21 monoclonal antibodies and the hybridomas that produce them are presented. Certain of these antibodies have the ability to bind native human IL-21, a mutant recombinat IL-21 protein and/or peptide regions of human IL-21. These human anti-IL-21 antibodies are useful in therapeutic treatment of autoimmune and inflammatory diseases, particularly diseases mediated by T follicular helper cells, B cells T2011-06-02
20110130549Method for the treatment of amyloidoses - The present invention relates to a method for the treatment of an amyloidosis such as Alzheimer's disease in a subject in need thereof, characterized in that it comprises administering an inhibitor of the interaction between Aβ globulomer and the P/Q type voltage-gated presynaptic calcium channel to said subject.2011-06-02
20110130550PROTEIN MONOMER, PROTEIN POLYMER OBTAINED FROM SAID MONOMER, AND DEVICE THAT CONTAINS THEM - A protein polymer having a larger molecular weight is provided by regularly arranging a protein having a large molecular weight. The protein polymer having a large molecular weight can be obtained using a protein monomer represented by formula (I) or a salt thereof:2011-06-02
20110130551Lipid Extraction From Microalgae Using A Single Ionic Liquid - A one-step process for the lysis of microalgae cell walls and separation of the cellular lipids for use in biofuel production by utilizing a hydrophilic ionic liquid, 1-butyl-3-methylimidazolium. The hydrophilic ionic liquid both lyses the microalgae cell walls and forms two immiscible layers, one of which consists of the lipid contents of the lysed cells. After mixture of the hydrophilic ionic liquid with a suspension of microalgae cells, gravity causes a hydrophobic lipid phase to move to a top phase where it is removed from the mixture and purified. The hydrophilic ionic liquid is recycled to lyse new microalgae suspensions.2011-06-02
20110130552AZO DYE - An azo dye represented by the following formula (I):2011-06-02
20110130553NOVEL SYNTHESIS OF GALACTOSIDE INHIBITORS - Novel synthesis routes for preparation of thiodigalactosides and intermediates are presented. The method includes the use of a 3-azido-galactosyl thiouronium salt derivative, which is activated to the corresponding thiol in situ, which in turn is directly reacted with a 3-azido-galactosyl bromide resulting in the 3,3′-di-azido-thio-di-galactoside before the thiol has a chance to reduce the azido 10 group. Hence, in situ formation of the 3-azido-galactosyl thiol from the thiouronium salt is essential in the synthesis procedure, because any other method that generate the thiol separately results in extensive unwanted azide reduction.2011-06-02
20110130554PROCESS FOR THE GLYCOSIDATION OF COLCHICINE AND THIOCOLCHICINE - A process for the preparation of compounds having formula (I) is disclosed, wherein: —R2011-06-02
20110130555LIPID-POLYMER CONJUGATES, THEIR PREPARATION AND USES THEREOF - This invention provides low molecular weight lipid-GAG and phospholipids-GAG conjugates and methods of use thereof in suppressing, inhibiting, preventing, or treating a pathogenic effect on a cell, including, inter alia, infection with intracellular pathogens.2011-06-02
20110130556METHOD FOR ENZYMATIC PRODUCTION OF GLP-2(1-33) AND GLP-2(1-34) PEPTIDES - The invention provides methods for making peptides from a polypeptide containing at least one copy of the peptide using clostripain to excise the peptide from the polypeptide. The methods enable the use of a single, highly efficient enzymatic cleavage to produce any desired peptide sequence.2011-06-02
20110130557INTERCALATING TRIPLEXES AND DUPLEXES USING ARYL NAPHTHOIMIDAZOL AND PROCESS FOR THE PREPARATION THEREOF - There is provided an intercalating oligonucleotide for stabilizing natural or modified DNA and RNA triplexes, duplexes and hybrids thereof having the general structure (I) triplex forming oligonucleotides of the invention are capable of binding specifically to double stranded target nucleic acids and are therefore of interest for modulation of the activity of target nucleic acids and also detection of target nucleic acids.2011-06-02
20110130558METHOD FOR ISOLATING NUCLEIC ACIDS - The invention relates to a method and kits for isolating and/or purifying nucleic acids, in particular, short-chain nucleic acids, from a nucleic acid containing starting material, characterised by the following method steps: (a) bonding the nucleic acids to a nucleic acid bonding support material, wherein the starting material is brought into contact with the nucleic acid bonding support material in the presence of at least one chaotropic compound and preferably isopropanol, wherein the isopropanol is present in a concentration of ≧15% (v/v) and ≦35% (v/v), (b) optional elution of the bonded nucleic acids from the nucleic acid bonding support material. Said method is particularly suitable for the purification of foetal DNA from maternal blood2011-06-02
20110130559Methods to Manufacture 1,3-Dioxolane Nucleosides - This application provides a process for preparing enantiomerically pure β-D-dioxolane nucleosides. In particular, a new synthesis of (−)-DAPD, suitable for large scale development, is described. In one embodiment the invention provides a process for preparing a substantially pure β-D- or β-L-1,3-dioxolane nucleosides comprising a) preparing or obtaining an esterified 2,2-dialkoxy ethanol; b) cyclizing the esterified 2,2-dialkoxy ethanol with glycolic acid to obtain a 1,3-dioxolane lactone; c) resolving the 1,3-dioxolane lactone to obtain a substantially pure D- or L-lactone; d) selectively reducing and activating the D- or L-chiral lactone to obtain a substantially pure D- or L-1,3-dioxolane; e) coupling the D- or L-1,3-dioxolane to an activated and/or protected purine or pyrimidine base; and f) optionally purifying the nucleoside to obtain a substantially pure protected β-D- or β-L-1,3-dioxolane nucleoside.2011-06-02
20110130560SONICATION CARTRIDGE FOR NUCLEIC ACID EXTRACTION - A cartridge in which sonication is applied to biological matter to disrupt and release nucleic acids from the matter is formed from a cartridge body containing a series of wells connected by fluid passages engineered to prevent backflow, with at least one well containing a sonication window covered by a thin lamina to transmit sonic vibrations from a sonication horn contacting the exterior surface of the window. Fluid transport among the wells is achieved by pressure differentials through the fluid passages, and a succession of functions is performed in the various wells, including disruption, mixing, binding of the released nucleic acids to binding materials, washing, elution, and collection.2011-06-02
20110130561METHOD FOR LYSING CELLULOSE - A method for obtaining a saccharide by lysing cellulose which is substance that is not readily lysed. Cellulose is mixed in acidic electrolyzed water, and the resulting mixture is stirred at a maximum temperature of 210° C. and at saturation vapor pressure of 1.9 MPa to obtain a saccharide.2011-06-02
20110130562Surfactant-Enabled Transition Metal-Catalyzed Chemistry - In one embodiment, the present application discloses mixtures comprising (a) water in an amount of at least 1% wt/wt of the mixture; (b) a transition metal catalyst; and (c) one or more solubilizing agents; and methods for using such mixtures for performing transition metal mediated bond formation reactions.2011-06-02
20110130563SYNTHESIS IF DIHYDROTHIENO[3,2-D]PYRIMIDINE DIOLS - The present invention relates to an improved process for the preparation of dihydrothieno[3,2-d]pyrimidine diols, and similar pyrimidine diols, that is efficient, high-yielding, and does not require expensive and potentially unstable intermediates. The diols are used as intermediates in the synthesis of pyrimidine compounds which inhibit PDE4, and are thus useful in the treatment of respiratory or gastrointestinal diseases and complaints, peripheral or central nervous system diseases and disorders, inflammatory conditions, and cancers.2011-06-02
20110130564COMPOUNDS USEFUL IN THE PREPARATION OF TRYPTOPHAN HYDRROXYLASE INHIBITORS - Intermediates and synthetic processes for the preparation of substituted phenylalanine-based compounds (e.g., of Formula I) are disclosed:2011-06-02
20110130565Luminescent Hybrid Liquid Crystal - Embodiments of the present disclosure include compounds including a M2011-06-02
20110130566Perylene tetracarboximide derivatives for photovoltaic devices - The compounds of the present invention are represented by the following formula (I):2011-06-02
20110130567STEROSELECTIVE SYNTHESIS OF CERTAIN TRIFLUOROMETHYL-SUBSTITUTED ALCOHOLS - A process for stereoselective synthesis of a compound of Formula (X)2011-06-02
20110130568Acylsulfonamides and Processes for Producing the Same - The present disclosure relates to acylsulfonamides and processes for their preparation. The processes involve a target-guided synthesis approach, whereby a thioacid and a sulfonyl azide are reacted in the presence of a biological target protein, a Bcl-2 family protein, to form the acylsulfonamide.2011-06-02
20110130569Process for the Preparation of d-threo-Ritalinic Acid Hydrochloride by Resolution of dl-threo-Ritalinic Acid Using Chiral Carboxylic Acid - The invention disclosed in this application relates to an improved process for the manufacture of d-threo-ritalinic acid hydrochloride and l-threo-ritalinic acid hydrochloride in an optically pure form by the resolution of dl-threo-ritalinic acid using a chiral carboxylic acid The d-threo-ritalinic acid hydrochloride prepared by the process of the present invention on esterification gives d-threo-methylphenidate, a very well known CNS stimulant.2011-06-02
20110130570Novel Form of S-Omeprazole - The present invention relates to a novel form of the (−)-enantiomer of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2 -pyridinyl)-methyl]sulfinyl]-12011-06-02
20110130571PROCESS FOR THE MANUFACTURE OF AGOMELATINE AND ITS INTERMEDIATE - A process for the manufacture of agomelatine and its intermediate N-[2-(7-methoxy-1-naphthyl)ethyl]phthalimide is provided and includes reacting 7-methoxy-1-naphthyl ethanol (III) with benzenesulfonyl chloride to obtain 7-methoxy-1-naphthylethyl benzene sulfonate (IV), which is reacted with potassium phthalimide to produce N-[2-(7-methoxy-1-naphthyl)ethyl]phthalimide (II); and subjecting N-[2-(7-methoxy-2011-06-02
20110130572METHODS OF SYNTHESIZING CYCLIC NITRO COMPOUNDS - The present invention provides cyclic nitro compounds, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.2011-06-02
20110130573METHOD FOR PRODUCING PHTHALIC ACID ANHYDRIDE - Method for the production of phthalic acid anhydride by catalytic gas phase oxidation of o-xylol with oxygen, in which the reaction is carried out in 5 to 60 serially arranged reaction zones under adiabatic conditions, and reactor system for carrying out the method.2011-06-02
20110130574CATALYST COMPOSITION INCLUDING ZIRCONIUM COMPOUNDS FOR ESTERFICATION REACTION AND METHOD FOR PREPARING ESTER COMPOUNDS - The present invention relates to an esterification catalyst composition that includes a zirconium compound and a method for producing an ester compound, which includes the steps of esterifying alcohol and carboxylic acid compounds by using the same, and it may be applied to a mass synthesis process.2011-06-02
20110130575SYNTHESIS OF CLAY-TEMPLATED SUBNANO-SIZED ZERO VALENT IRON (ZVI) PARTICLES, CLAYS CONTAINING SAME, AND USE OF BOTH IN CONTAMINANT TREATMENTS - A clay comprising a 2:1 aluminosilicate clay having negative charge sites, the 2:1 aluminosilicate clay containing subnano-sized zero valent iron (ZVI) particles distributed on clay surfaces is provided. In one embodiment, at least some or all of the particles have a cross-section of five (2011-06-02
20110130576PROCESS FOR PRODUCING (Z)-1-PHENYL-1-(N,N-DIETHYLAMINOCARBONYL)-2-PHTHALIMIDOMETHYLCYCLOPROPANE - The present invention provides a process for producing (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-phthalimidomethylcyclopropane, which includes reacting (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-hydroxymethylcyclopropane with an orthoester and a brønsted acid, and reacting the reaction product with a phthalimidating agent; and a process for producing (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-aminomethylcyclopropane hydrochloride through the above process.2011-06-02
20110130577Process for the Preparation of Prostaglandin Analogues and Intermediates Thereof - The present application provides intermediates for preparing prostaglandin analogues and processes for preparing prostaglandin analogues and intermediates thereof. The intermediates include: A compound of formula (6):2011-06-02
20110130578STEREOSELECTIVE SYNTHESIS OF CERTAIN TRIFLUOROMETHYL-SUBSTITUTED ALCOHOLS - A process for stereoselective synthesis of a compound of Formula (X) or Formula (X′)2011-06-02
20110130579PROCESS FOR THE PREPARATION OF A TITANIUM ZEOLITE CATALYST - A process for the preparation of a catalyst for the use in a hydrocarbon conversion reaction, said catalyst containing a titanium zeolite and carbonaceous material, the catalyst containing said carbonaceous material in an amount of from 0.01 to 0.5% by weight based on the total weight of titanium zeolite contained in the catalyst, the process comprising (i) preparing a catalyst containing the titanium zeolite and (ii) depositing carbonaceous material on the catalyst according to (i) in an amount of from 0.01 to 0.5% by weight based on the total weight of titanium zeolite contained in the catalyst by contacting said catalyst, prior to using the catalyst in said hydrocarbon conversion reaction, with a fluid containing at least one hydrocarbon in an inert atmosphere, to obtain the carbonaceous material containing catalyst, wherein in (ii), the catalyst is not contacted with an oxygen containing gas.2011-06-02
20110130580USE OF BUCKYSOME OR CARBON NANOTUBE FOR DRUG DELIVERY - Compositions and methods for administering a therapeutic agent to a mammal are disclosed. The compositions comprise either (i) vesicles comprising an amphiphilic substituted fullerene, wherein the therapeutic agent is present in the vesicle interior or between layers of the vesicle wall, (ii) a substituted fullerene, comprising a fullerene core and a functional moiety, wherein the therapeutic agent is associated with the substituted fullerene, or (iii) carbon nanotubes, wherein the therapeutic agent is covalently bonded to the carbon nanotubes.2011-06-02
20110130581Method and intermediates for preparing 2-alkoxy and 2-aryloxy estrogen compounds - The present invention relates to 2-alkoxy and 2-aryloxyestrogen compounds, and the intermediate compounds prepared during the preparation thereof, which intermediate compounds are useful intermediates in the preparation of certain physiologically active compounds.2011-06-02
20110130582PROCESS FOR PREPARING (METH)ACRYLATES OF C17-ALCOHOL MIXTURES - A process for preparing (meth)acrylates of C2011-06-02
20110130583Phosphorylcholine Group-Containing Compound And Surface Modifying Agent Composed Of Such Compound - A phosphorylcholine group-containing chemical compound represented by the following formula (1).2011-06-02
20110130584INSULATING FILM MATERIAL, METHOD OF FILM FORMATION USING INSULATING FILM MATERIAL, AND INSULATING FILM - An insulating film material for plasma CVD represented by a chemical formula (1) shown below, a method of film formation using the insulating film material, and an insulating film. According to the present invention, an insulating film having a low dielectric constant and a superior copper diffusion barrier property suitable for an interlayer insulating film or the like of a semiconductor device can be obtained. In the chemical formula (1), n represents an integer of 3 to 6, and each of R2011-06-02
20110130585METHOD OF PREPARING ALLYLCHLOROSILANE DERIVATIVE - Provided is a method of preparing allylchlorosilane, and more particularly, a method of preparing allylchlorosilane with high yield by Si—C coupling reaction of an allyl chloride derivativce with a hydrosilane derivative under specific reaction conditions without using a catalyst.2011-06-02
20110130586RECOVERY OF MULTIPLE COMPOUNDS AND RECYCLABLE WATER FROM THIN STILLAGE - Methods for recovery of recyclable water and/or fermentation co-products from thin stillage process streams. Microbial metabolites and/or plant derivatives and/or plant extractives are removed from thin stillage after which, recyclable water is recovered from the processed thin stillage. Thin stillage is commingled with one or more polar organic solvents to react microbial metabolites and/or plant derivatives and/or plant extractives with the organic solvents. The reacted organic solvents are then separated from the processed thin stillage. Thin stillage may be commingled with an oil to re act with certain organic compounds, after which, the reacted oil is separated from the processed thin stillage is further extracted with one or more polar organic solvents. Alternatively, thin stillage may be first processed with one or more polar organic solvents, and then processed with an oil. Useful organic compounds may recovered from the reacted oil and from the reacted organic solvents.2011-06-02
20110130587PROCESS FOR PREPARING R-BETA-AMINO PHENYLBUTYRIC ACID DERIVATIVES - Disclosed is a process for preparing single enantiomers of beta-amino phenylbutyric acid derivatives and pharmaceutically acceptable salts thereof, which affords the desired compounds having special optical configuration. The process comprises a step of chemical synthesis and a step of resolving the optical isomers of beta-amino phenylbutyric acid derivatives with a resolving agent. The resolving step comprises reacting the optical isomers with resolving agents, such as di-para-toluoyl-L-tartaric acid and di-para-toluoyl-D-tartaric acid. The obtained R-beta-amino phenylbutyric acid derivatives (I) have high optical purity, and the total yield of the accumulative resolution of the laevo and the dextro isomer is up to above 70%.2011-06-02
20110130588COMPOSITION, AND ORGANIC PHOTOELECTRIC CONVERSION ELEMENT COMPRISING SAME - Disclosed is a composition produced by reacting a fullerene derivative with a reducing agent. The composition is preferably produced by adding a reducing agent to a composition comprising a fullerene derivative and a solvent to cause the reaction of the fullerene derivative and the reducing agent. The reducing agent is preferably a trivalent phosphorus compound.2011-06-02
20110130589PROCESS FOR THE PREPARATION OF BIS(FLUOROALKYL)PHOSPHINIC ACID OR FLUOROALKYLPHOSPHONIC ACID - The invention relates to a process for the preparation of bis(fluoroalkyl)phosphinic acid and/or fluoroalkylphosphonic acid by reaction of, monofluoroalkyltetrafluorophosphorane bis(fluoroalkyl)trifluorophosphorane or tris(fluoroalkyl)difluorophosphorane with water.2011-06-02
20110130590METHOD FOR THE PRODUCTION OF (METH)ACRYLIC ESTERS - The present invention relates to a process for preparing (meth)acrylates, comprising the transesterification of a low-boiling ester of (meth)acrylic acid with a reactant alcohol in the presence of catalysts, which is characterized in that the transesterification is catalysed by a basic ion exchanger.2011-06-02
20110130591STEROSELECTIVE SYNTHESIS OF CERTAIN TRIFLUOROMETHYL-SUBSTITUTED ALCOHOLS - A process for synthesis of a compound of Formula (X)2011-06-02
20110130592Catalyst and Process for Hydrogenating Organic Compounds - The invention relates to a catalyst and a process for hydrogenating organic compounds.2011-06-02
20110130593SOLUBLE, PERSISTENT NONACENE DERIVATIVES - The present invention is directed towards a new class of semi-conducting nonacene derivatives. These compounds are all soluble species and they all possess superior resistance to oxidation as compared to their counterparts that lack the substitution patterns disclosed herein.2011-06-02
20110130594CLASS OF SOLUBLE, PHOTOOXIDATIVELY RESISTANT ACENE DERIVATIVES - The present invention is directed towards a new class of semi-conducting acene derivatives. These compounds are all soluble species and they all possess superior resistance to photooxidation as compared to their counterparts that lack the substitution patterns disclosed herein.2011-06-02
20110130595PROCESS FOR PREPARING C5 ALDEHYDE MIXTURES WITH A HIGH N-PENTANAL CONTENT - A process for preparing a C2011-06-02
20110130596PROCESS FOR PREPARING (METH)ACROLEIN BY HETEROGENEOUSLY CATALYZED GAS PHASE PARTIAL OXIDATION - A process for preparing (meth)acrolein by heterogeneously catalyzed gas phase partial oxidation of a precursor compound, in which the reaction gas mixture which comprises at least 3% by volume of precursor compound is passed through a fresh fixed catalyst bed whose active material is a multielement oxide which comprises the elements Mo, Fe and Bi and at least one of the elements Ni and Co, and the fixed catalyst bed is loaded with at least 40 l (STP)/l·h of precursor compound, and the precursor compound is converted to an extent of at least 90 mol %, wherein, over the first 8000 operating hours, during X=10 to 500 operating hours, the highest temperature of the reaction gas mixture in the fixed catalyst bed is 400 to 450° C. and, during the remaining 8000−X operating hours, is 300 to <400° C., and the loading of the fixed catalyst bed with organic precursor compound, averaged over the time, for the X=10 to 500 operating hours is greater than for the 8000−X operating hours.2011-06-02
20110130597Method of producing alcohols - A method comprising reacting an alkane gas with a halogen gas in a halogenations reactor to form a halogenation reaction product mixture comprising alkane halide and hydrogen halide mixture; mixing the halogenations reaction product mixture with a countercurrent flow of a metal organic salt thereby forming an extractor product mixture of a metal halide, organic salt, and organic acid separating the organic ester and organic acid mixture from the metal halide; oxygenating the metal halide to form a metal oxide and halide containing gasses; separating the metal oxide from the halide containing gasses; mixing the metal oxide with water to form a metal oxide slurry; mixing the metal oxide slurry with a countercurrent flow of the organic ester and organic acid mixture to form a raw product comprising alkanol, a metal organic salt is provided.2011-06-02
20110130598MEMBRANE AUGMENTED DISTILLATION TO SEPARATE SOLVENTS FROM WATER - Processes for removing water from organic solvents, such as ethanol. The processes include distillation to form a rectified overhead vapor, compression of the rectified vapor, and treatment of the compressed vapor by two sequential membrane separation steps.2011-06-02
20110130599CATALYTIC GAS PHASE FLUORINATION OF 1230XA TO 1234YF - A one reactor, gas phase catalyzed process for the fluorination of 1,1,2,3-tetrachloropropene (1230xa) to produce 1,1,1,2-tetrafluoropropene (1234yf) is disclosed. The process of the present invention is a catalytic, gas phase fluorination using a high pressure activated catalyst which is supported or unsupported. Fluorination products of the formula CF3R, where R is selected from —CCl=CH2, —CF=CH2, —CF2—CH3, —CFCl—CH3 and mixtures thereof are produced. Co-produced materials are separated from the desired product and recycled to the same reactor.2011-06-02
20110130600METHOD FOR PRODUCING CYCLOOLEFIN AND PRODUCTION APPARATUS THEREOF - There is provided a method for producing cycloolefin where the nickel which elutes in the liquid-contact portion of the reactor is removed from the reaction system of the partial hydrogenation reaction and cycloolefin can be stably produced from a monocyclic aromatic hydrocarbon over a long term. A method for producing a cycloolefin by a partial hydrogenation reaction of a monocyclic aromatic hydrocarbon in an aqueous phase, which contains a metal salt-containing acidic aqueous solution and a ruthenium catalyst in a reactor with a liquid-contact portion formed of a nickel-containing material, the method comprising a first step of bringing at least a part of the ruthenium catalyst contained in the aqueous phase into contact with oxygen, a second step of separating the aqueous phase containing the ruthenium catalyst that has been processed in the first step into a first phase containing the ruthenium catalyst at a high ratio and a second phase containing the ruthenium catalyst at a lower ratio than the first phase, and a third step of feeding the first phase to a reaction system of a partial hydrogenation reaction.2011-06-02
20110130601PROCESS FOR REACTING ISO-PENTANE - A process for reacting an iso-pentane with an olefinic feedstock, comprising:2011-06-02
20110130602PROCESS FOR REACTING ISO-ALKANE - A process for reacting an iso-alkane, comprising: 2011-06-02
20110130603Aromatics Processing Catalyst System - This disclosure relates to a catalyst system adapted for processing aromatic feedstreams comprising C2011-06-02
20110130604SYSTEM AND PROCESS FOR PRODUCING LINEAR ALPHA OLEFINS - Processes and systems for producing linear alpha olefins are described herein. One embodiment is a process comprising: a) separating a mixed butene stream comprising 1-butene and 2-butene into an overhead 1-butene stream and a bottoms 2-butene stream in a butene distillation column, a portion of the bottoms 2-butene stream being separated to form a butene reboiler stream that is heated and vaporized in a reboiler and returned to the butene distillation column, (b) subjecting at least a portion of the overhead 1-butene stream from (a) to catalytic metathesis to produce an effluent including 3-hexene, (c) isomerizing 3-hexene from (b) to produce a mixed hexene stream comprising 1-hexene, 2-hexene and 3-hexene, (d) separating the mixed hexene stream in a hexene fractionation tower to form a 1-hexene vapor overhead stream that is condensed in a cooler and a bottoms stream comprising 2-hexene and 3-hexene, and (e) using heat obtained by condensing the 1-hexene vapor overhead stream of (d) to heat the butene reboiler stream of (a). Another embodiment is a superfractionation process. Corresponding systems are also disclosed.2011-06-02
20110130605Regeneration and Stabilization of Dehydrogenation Catalyst - The present invention relates to a process for catalytically converting an alkylaromatic hydrocarbon into a vinylaromatic hydrocarbon by directing said alkylaromatic hydrocarbon and steam into a reactor containing dehydrogenation catalyst, said process comprising the steps of: 2011-06-02
20110130606PROCESS FOR OBTAINING BENZENE, TOLUENE (AND NAPHTHALENE) FROM C1-C4-ALKANES WITH CO-DOSAGE OF HYDROGEN OF A SEPERATE LOCATION - The present invention relates to a process for nonoxidatively dehydroaromatizing a reactant stream comprising C2011-06-02
20110130607REACTOR FOR CARRYING OUT AUTOTHERMAL GAS-PHASE DEHYDROGENATIONS - A reactor (2011-06-02
20110130608Alkylation of Aromatic Substrates and Transalkylation Process - The present invention is a process for the alkylation of an aromatic substrate comprising:2011-06-02
20110130609Dilute Liquid Phase Alkylation - Methods of forming ethylbenzene are described herein. In one embodiment, the method includes contacting dilute ethylene with benzene in the presence of an alkylation catalyst to form ethylbenzene, wherein such contact occurs in a liquid phase reaction zone and recovering ethylbenzene from the reaction zone.2011-06-02
20110130610ZEOLITE CATALYST FOR HYDROISOMERIZATION OF LIGHT PARAFFINS TO PRODUCE HIGH OCTANE GASOLINE - The present invention is directed to a process for isomerizing light paraffins by using a catalyst containing a zeolite selected from the group consisting of CON- and TUN-type zeolites, and at least one Group VIII metal. It has been found that the CON- and TUN-type zeolite catalysts of the present invention selectively convert C2011-06-02
20110130611PROCESS FOR MEMBRANE SEPARATION OF AN OLEFIN THAT IS CONTAINED IN A HYDROCARBON MIXTURE - This invention relates to the field of processes for membrane separation and applies in particular to the purification of C2 or C3 olefins. This process makes it possible more particularly to separate propylene from a mixture that contains other C3 hydrocarbons such as propane. The membranes that are used in the process according to this invention are vitreous polymer-based membranes whose pattern contains a bis-phenyl-9,9-fluorene group.2011-06-02
20110130612DISPOSAL OF HUMAN REMAINS - An alkaline hydrolysis unit, and method of using the same to dispose of a cadaver, the alkaline hydrolysis unit comprising: a chamber for receiving a cadaver to be chemically decomposed, the chamber including a head-receiving part intended to receive the head of a cadaver; a recirculation pump fluidly connected to the chamber of the alkaline hydrolysis unit and adapted to recirculate fluids within the chamber; a head retaining means locatable in the chamber for retaining the head of the cadaver in the head-receiving part of the chamber; and at least one recirculation jet fluidly connected to the recirculation pump and positioned to aim fluid from the recirculation pump at the head-receiving part of the chamber.2011-06-02
20110130613MECHANOLUMINESCENT X-RAY GENERATOR - A device for generating x-rays has an enclosing vessel having a structure suitable to provide an enclosed space at a predetermined fluid pressure, wherein the enclosing vessel has a window portion and a shielding portion in which the shielding portion is more optically dense to x-rays than the window portion; a mechanoluminescent component disposed at least partially within the enclosing vessel; and a mechanical assembly connected to the mechanoluminescent component. The mechanical assembly provides mechanical energy to the mechanoluminescent component while in operation, and at least some of the mechanical energy when provided to the mechanoluminescent component by the mechanical assembly is converted to x-rays.2011-06-02
20110130614PROSPECTIVE ADAPTIVE RADIATION THERAPY PLANNING - A therapy planner (2011-06-02
20110130615MULTI-MODALITY NEUROMODULATION OF BRAIN TARGETS - Disclosed are methods and systems and methods for deep or superficial deep-brain stimulation using multiple therapeutic modalities. These impact multiple points in a neural circuit or one or multiple points in multiple neural circuits to produce Long-Term Potentiation (LTP) or Long-Term Depression (LTD) to treat indications such as neurologic and psychiatric conditions. Modality examples are implanted deep-brain stimulators (DBS), Transcranial Magnetic Stimulation (TMS), transcranial Direct Current Stimulation (tDCS), implanted optical stimulation, focused ultrasound, RF stimulation, vagus nerve stimulation, other-implant stimulation, functional stimulation, and drugs. Some targets may be up-regulated and others down-regulated. Coordinated control is provided, as applicable, for control of the direction of the energy emission, intensity, session duration, frequency, pulse-train duration, phase, and numbers of sessions, if and as applicable, for neurormodulation of neural targets. Use of ancillary monitoring or imaging to provide feedback may be applied.2011-06-02
20110130616Magnetically Responsive Nanoparticle Therapeutic Constructs and Methods of Making and Using - Magnetically responsive therapeutic carriers comprise nanoparticles including single-domain nanoparticles comprising magnetite and having an average particle size ranging between 1 and 50 nanometers, clusters of the single-domain nanoparticles, the clusters having an average cluster size ranging between 5 and 1000 nanometers, and mixtures of the two. The single-domain nanoparticles are encapsulated with a silica coating. A silane coupling agent is bonded to the silica coating and has a specific pendant functional group capable of selectively binding with the therapeutic. Preferably, the bond between the specific pendant functional group and the therapeutic is a covalent bond. The movement of magnetically responsive nanoparticle therapeutic constructs, with concentration and extravasation/endocytosis at a target site, such as cancerous tumors, uses a controllable magnetic field generator adapted to move the therapeutic constructs in three dimensions, and is enhanced using a repetitively-varying magnetic field. A method for treating cancer comprises administering and magnetically guiding a therapeutic construct comprising paclitaxel.2011-06-02
20110130617MAGNETIC SYSTEM FOR TREATMENT OF CELLULAR DYSFUNCTION OF A TISSUE OR AN EXTRACELLULAR MATRIX DISRUPTION OF A TISSUE - A system, kit, and pet bed for treating tissue using magnetic coils connected to a pulse generator. The system can include a power supply, a bi-directional communication and power port, a microcontroller, a processor, a data storage, and a Helmholtz-like magnetic coil pair. The kit can include a saddlebag and a support strap. The pet bed can include bedding, a fabric housing, a Halbach array, and an on/off switch.2011-06-02
20110130618ESTHETIC APPARATUS USEFUL FOR INCREASING SKIN REJUVENATION AND METHODS THEREOF - The present invention provides a system for increasing skin rejuvenation of a region of a patient's skin comprising a pulsed electromagnetic field (PEMF) frequency generator for constantly providing electromagnetic pulses to said region of a patient's skin and a deep tissue diathermy device for constantly applying heat to said region of a patient's skin up to temperature T. The system is adapted for simultaneously applying heat and PEMF to the region of a patient's skin,—wherein application of the system increases skin rejuvenation such that the skin rejuvenation increase (SRI) is greater than the sum of the SRI provided by electromagnetic pulses increase and the SRI provided by the deep tissue diathermy device increase.2011-06-02
20110130619VENTRICULAR ASSIST DEVICE AND RELATED METHODS - A method and system are provided for percutaneously gaining access to oxygenated blood with one or more anastomosis devices and pumping such oxygenated blood directly to the aorta adjacent to the right atrium or left atrium via a VAD system. In one embodiment, a VAD system can be implanted with open surgery.2011-06-02
20110130620 INFANT CARE APPARATUS WITH MULTIPLE USER INTERFACES - An infant care apparatus with multiple user interfaces is disclosed herewith. The apparatus comprises: a base; a frame member extending upwardly from said base; an infant platform extending outwardly from said frame member positioned above the base and having lateral side walls and a bottom support. The apparatus further comprises a heating arm extending outwardly from said frame member, positioned above the infant platform and at least one drive mechanism connected to the frame member and to the infant platform. The drive mechanism is provided with at least one user interface extending to the lateral side walls of the infant platform for moving the infant platform.2011-06-02
20110130621INFANT WARMER - An infant warmer apparatus includes a base, a crib and a frame. The frame includes a support plate assembly comprising a plate member defining a pivot aperture and a notch. The heater assembly includes a canopy, and a mounting shaft. The mounting shaft defines a first terminal end secured to the canopy and a second terminal end passing through the pivot aperture of the plate member. The mounting shaft includes a biasing pin configured to settle within the notch of the plate member when the heater assembly is in a neutral position relative to the frame. The mounting shaft is rotatable within the pivot aperture such that the heater assembly can be pivoted in either a clockwise or counter-clockwise direction from the neutral position. A controller is configured to turn off the heater assembly when the heater assembly is pivoted out of the neutral position.2011-06-02
20110130622Inductive Signal and Energy Transfer through the External Auditory Canal - An inductive coil arrangement is described for an ear canal of a recipient patient. An inner transmitter coil inserts into the ear canal for transmitting a communication signal through the skin of the outer wall of the ear canal. The transmitter coil includes transmission wire loops that lie substantially in a common plane which curves around the central axis of the ear canal conformal to the outer wall of the ear canal. An outer receiver coil is implantable under the skin of the outer wall of the ear canal for receiving the communication signal from the transmitter coil. The receiver coil includes receiver wire loops that lie substantially in a common plane which curves around the central axis of the ear canal substantially parallel to the transmitter coil.2011-06-02
20110130624SYSTEM AND METHOD FOR ATTACHING A VESSEL IN A VASCULAR ENVIRONMENT - An apparatus is provided in one example embodiment and includes a body section having an upper surface, a lower surface, and an inner edge circumferentially arranged around at least a portion of an open area. The apparatus also includes a tool extending from the body section into the open area for holding a graft vessel. The lower surface of the body section opposes a receiving vessel when the tool is positioned to transfer the graft vessel to the receiving vessel, such that the graft vessel is axially accessible through the open area to be attached to the receiving vessel. In more specific embodiments, the body section has first and second opposing ends defining a gap sized to permit the vessel to pass through.2011-06-02
20110130625APPARATUS AND METHODS FOR CORRECTIVE GUIDANCE OF EATING BEHAVIOR AFTER WEIGHT LOSS SURGERY - Apparatuses and methods for corrective guidance of eating behavior of a patient equipped with a gastric restriction device. The apparatus provides continuous monitoring or one or more parameters related to food passing through the gastric restriction device. Each monitored parameter is processed to provide a visual indication of the current eating behavior. The visual indication is used as input to the patient or a caregiver to modify the eating behavior. In some embodiments, the apparatus includes an emergency relief mechanism that automatically relieves excess pressure developing in the gastric restriction device. In some embodiments, the apparatus is enabled to deliver an appetite suppressant to modify the eating behavior.2011-06-02
20110130626Non-Invasive Measurement of Fluid Pressure In An Adjustable Gastric Band - A food intake restriction device for forming a restriction in a patient's gastro-intestinal tract and non-invasively communicating pressure data regarding the restriction to an external monitor. The device includes a food intake restriction device implanted substantially about a patient's gastro-intestinal tract to form a restricted opening in the tract. A port is connected to the restriction device. The port contains a working fluid for affecting the size of the restricted opening. A pressure sensing system communicates with the working fluid to measure the pressure of the working fluid. A transmitter communicates the measured fluid pressure to the external monitor.2011-06-02
20110130627Visualization Instrument - A visualization instrument comprising a display support component removably coupled to a component insertable into a target space. The insertable component includes a camera providing images of the target space. The images are presented in a display device supported by the display support component. The insertable component may be discarded after a permitted number of uses.2011-06-02
20110130628Method for Transmitting Torque and Variably Flexing a Corrugated Insertion Device - A method for transmitting torque and variably flexing an insertion device for receiving an instrument includes the steps of providing a hollow body having a proximal end with an entrance for receiving an instrument, a distal end with a tip for protrusion of the instrument, an outer jacket and an inner sleeve, maintaining the hollow body in relatively flexible and relatively stiff conditions with wires disposed at least partly between the outer jacket and the inner sleeve and being free of at least one of the outer jacket and the inner sleeve, transmitting torque along the hollow body with a corrugated tube disposed between the outer jacket and the inner sleeve, and applying suction to create a vacuum between the outer jacket and the inner sleeve for placing the hollow body in the relatively stiff condition and relieving the vacuum for placing the hollow body in the relatively stiff condition, with a transitioning device for frictionally locking the wires and the corrugated tube in place.2011-06-02
20110130629ENDOSCOPE COVER FIXING DEVICE AND FIXING SYSTEM - An endoscope cover fixing device to reliably fix a cover to an endoscope without associated damage. The endoscope cover fixing device includes a fixing device main body and a pair of fixing protrusion portions. The fixing device main body includes a curved portion and insert holes, and is deformable in the direction in which the bend amount increases. The pair of fixing protrusion portions, which have contact surfaces, are provided to protrude from a concave surface side of the fixing device main body and are disposed in two opposing regions of the concave surface. The contact surfaces are disposed in parallel with a fixed distance therebetween. During deformation of the fixing device main body, the pair of fixing protrusion portions move in parallel in opposing directions. As a result, the contact surfaces contact opposing positions on the outer circumferential surface of the endoscope by way of the cover.2011-06-02
20110130630Method for Transmitting Torque and Variably Flexing a Corrugated Insertion Device - A method for transmitting torque and variably flexing an insertion device for receiving an instrument includes the steps of providing a hollow body, transmitting torque along the hollow body with a corrugated tube, applying suction to create a vacuum in the hollow body for placing the hollow body in a relatively stiff condition, relieving the vacuum for placing the hollow body in a relatively flexible condition, maintaining the hollow body in the relatively flexible and relatively stiff conditions with tendons disposed within the hollow body, and individually adjusting at least some of the tendons in length for steering a distal end of the hollow body.2011-06-02
20110130631ADAPTER DEVICE TO COUPLE AN ENDOSCOPE WITH A MEDICAL APPLIANCE - An adapter device, which is configured to couple an endoscope with a medical appliance, such that the medical appliance is provided to generate light to illuminate an object to be investigated by an endoscope, includes an adapter body with a through-hole through which light generated by the medical appliance can be transmitted, and a fastening device to removably secure the adapter body on the medical appliance. The side of the adapter body that is to face the medical appliance is configured to be held form-locked in a predetermined angle position when the adapter body is secured on the medical appliance.2011-06-02
20110130632Visualization Instrument - A visualization instrument comprising a display support component removably coupled to a component insertable into a target space. The insertable component includes a camera providing images of the target space. The images are presented in a display device supported by the display support component. The insertable component may be discarded after a permitted number of uses.2011-06-02
20110130633CIRCULAR SURGICAL RETRACTOR - A wound retractor for retracting a surgical incision includes an inner ring, an outer ring and a distensible sleeve coupled to the inner and outer rings. The outer ring includes at least a pair of circular tubes coupled to each other. At least one of the circular tubes includes a lumen and a split that forms open ends. A noncompliant tubular hoop having a split therein is positioned in the lumen. The tubular hoop is oriented with its open ends positioned away from the split of the circular tubes. A core is positioned in the lumen of the tubular hoop. The core has a first end and a second end and is oriented with the ends positioned away from the split in the tubular hoop. The circular tubes may be parallel or may form a helical pattern similar to a Mobius strip.2011-06-02
20110130634PATIENT-MOUNTED RETRACTION - Patient-mounted retractors with varying configurations and/or features are provided, along with additional components for use therewith in provided patient-mounted retractor assemblies. Blade type and tube type patient-mounted retractors that may be re-positioned during the course of a procedure are provided in varying configurations and/or geometries suitable for varying procedures and/or patient anatomies. Applications of re-positionable patient-mounted retractor assemblies are particularly suitable for use in minimally invasive procedures, eliminating the need for table-mounted retraction assemblies and/or cannulas that restrict the operating environment.2011-06-02
20110130635Medical self-service - Techniques for medical self-service are provided. A kiosk interacts with a patient to establish a patient identity, acquire medical records for the patient, and acquire one or more medical vital readings for the patient. The kiosk then packages the information in a summary that is electronically provided to medical personnel before a patient is addressed by the medical personnel at a medical facility.2011-06-02
20110130636Systems, Methods and Devices for the Rapid Assessment and Deployment of Appropriate Modular Aid Solutions in Response to Disasters. - The invention relates generally to systems, devices and methods for global disaster response, more particularly to the rapid detection, qualified assessment and monitoring of disasters and electronic triage of victims, communication, alert and evacuation systems, provision of suitable modular sensing or medical aid solutions, and their rapid deployment via delivery platforms such as disaster messaging formats and resources on client mobile phone applications or physically via remote operated vehicles (unmanned aerial sea or land systems) or targeted air delivery.2011-06-02
20110130637PROTEIN PRODUCT FOR MODIFYING CARDIOVASCULAR HEALTH - A composition for use in the treatment or prophylaxis of conditions mediated by endothelial function in mammals is provided. The composition includes a milk protein hydrolysate generated by treating milk or milk whey protein with a proteolytic enzyme having subtilisin or subtilisin-like activity and/or glutamyl endopeptidase or glutamyl endopeptidase-like activity. The composition is useful in the management of vascular conditions.2011-06-02
20110130638MEDICAL SENSOR AND TECHNIQUE FOR USING THE SAME - A medical sensor may be adapted to account for factors that cause irregularities in pulse oximetry measurements or other spectrophotemetric measurements. Sensors are provided with surface features that reduce the amount of outside light or shunted light that impinge the detecting elements of the sensor. The sensor is adapted to reduce the effect of outside light or shunted light on pulse oximetry measurements.2011-06-02
20110130639Method and System for Providing Continuous Calibration of Implantable Analyte Sensors - Method and system for providing continuous calibration of analyte sensors includes calibrating a first sensor, receiving data associated with detected analyte levels from the first sensor, and calibrating a second sensor based on a predetermined scaling factor and data associated with detected analyte levels from the first sensor, is disclosed.2011-06-02
20110130640Electrode Capable of Attachment to a Garment, System, and Methods of Manufacturing - An electrode for selective attachment to at least one of a garment and a subject, is provided and includes a conductive member defining a first side and a second side; a conductive composition disposed on the first side of the conductive member, wherein the conductive composition has a first adhesive strength; a contact layer disposed on the second side of the conductive member, wherein the contact layer includes a pressure sensitive adhesive portion and a conductive hydrogel portion, wherein the pressure sensitive adhesive portion has a second adhesive strength that is greater than the adhesive strength of the conductive composition; whereby the electrode is adherable to the garment and to the subject such that the conductive composition is adhered to the subject and the pressure sensitive adhesive portion is adhered to the garment, wherein removal of the garment from the subject results in removal of the electrode from the subject.2011-06-02
20110130641IMAGER FOCUSING BASED ON INTRAOPERATIVE DATA - Various embodiments herein provide for imager focusing based on intraoperative data. Ideally, an imaging plane of an ultrasound transducer would be truly planar. That is not the case, though. Instead, ultrasound transducers image a volume that is closer to a rectangular volume, but that has focal depths or areas in the imaged volume that are “thinner” and provide a better resolution. In general, embodiments herein may include determining the pose of an imager, such as an ultrasound transducer, and the pose of a location of interest. Based on those poses, a focal adjustment may be determined in order to, for example, better focus the imager on the object of interest. Then data is generated and the focus of the imager is adjusted. Additionally, imaging data and/or the object of interest may be displayed. In other embodiments, estimated projections of medical devices are displayed to allow for better intraoperative planning.2011-06-02
20110130642SYSTEM AND METHOD FOR TRACKING HEALING PROGRESS OF TISSUE - A system and method for analyzing tissue healing may include capturing an image including a tissue site. A clinician may be enabled to define multiple regions of the image of the tissue site, where at least two of the regions of the image define tissue types at different stages of tissue healing. An area may be calculated of each of the at least two regions of the image defining tissue type at different stages of tissue healing. The calculated areas may be displayed to a clinician. In one embodiment, an image color adjustment may be determined by adjusting the image of the reference color marker to the predetermined color. The image of the tissue site may be normalized by applying the image color adjustment to generate a normalized image.2011-06-02
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