22nd week of 2012 patent applcation highlights part 42 |
Patent application number | Title | Published |
20120135821 | Golf Club Heads Or Other Ball Striking Devices Having Distributed Impact Response - A ball striking device, such as a golf club head, includes a face having a ball striking surface configured for striking a ball and a body connected to the face and extending rearwardly from the face. The body has an impact-influencing structure in the form of a channel positioned on at least one surface of the body. A majority of a force generated by impact with a ball is absorbed by the impact-influencing structure, and a majority of a response force generated by the head upon impact with the ball is generated by the impact-influencing structure. The face may have increased stiffness as compared to existing faces, and may include a stiffening structure to create the increased stiffness, such as a porous or cellular stiffening structure. | 2012-05-31 |
20120135822 | GOLF CLUB HEAD HAVING A MULTI-MATERIAL FACE - A golf club with a multi-material face is disclosed herein. More specifically, the golf club head in accordance with the present invention has a striking face that forms a pocket, wherein the pocket is filled with a secondary material having a lower density to improve the performance of the golf club head. The multi-material face disclosed in accordance with the present invention may generally have a characteristic time slope of greater than about 5 and less than about 50, wherein the characteristic time slope is determined based on the various data points collected according to the United States Golf Association's (USGA's) Characteristic Time (CT) test. | 2012-05-31 |
20120135823 | METHOD FOR SELECTING ORGANIC SULFUR COMPOUND FOR GOLF BALL, METHOD FOR PRODUCING GOLF BALL, AND GOLF BALL - An object of the present invention is to provide a golf ball having high resilience. The gist of the present invention resides in selecting an organic sulfur compound used for a golf ball rubber composition containing (a) a base rubber, (b) a co-crosslinking agent, (c) a crosslinking initiator, and (d) the organic sulfur compound from organic sulfur compounds having specific structures such that a sum of substituent constants of the substituents X in a structure represented by the following formula (4) is 0.2 or more and SP value of the structure represented by the following formula (4) is in a range from 19.0 (J/cm | 2012-05-31 |
20120135824 | GREEN REPAIR TOOL, GOLF ACCESSORY, AND COMBINATION GOLF BALL MARKER RETENTION AND GREEN REPAIR TOOL DEVICE - A golf accessory for retaining a marker therein, the accessory having a body, the upper end thereof including a semi-circular recess dimensioned to receive a removable metallic ball marker fixedly retainable within the recess. The accessory includes a pair of spaced prongs contiguous with and extending downward from the lower end of the body to prong tips, a first plurality of magnets embedded in the body adjacent the semi-circular recess, and a second plurality of magnets embedded in the spaced prongs. | 2012-05-31 |
20120135825 | INTERACTIVE DEVICE FOR VIDEO GAMES - The invention concerns a device for interactive football practice combined with an imaging and sound system constituting the football programme to be followed by a player, comprising an object relatively fixed to the ground (I), of spherical shape which the player can kick, and various means for determining the types of kicks practised by the player and the intensity thereof. | 2012-05-31 |
20120135826 | BAT HAVING VARIABLE PROPERTIES RELATIVE TO A SWING AXIS - A bat having different stiffnesses in different planes relative to a longitudinal axis (i.e., swing axis) of the bat. More specifically, the bat includes a greater stiffness in a vertical plane as compared to relatively more flexible stiffness in a swing plane. This differential stiffness may be accomplished with an intermediate material located within an internal space defined where a handle affixes to a barrel of the bat or alternatively with a transitional member structurally arranged between the handle and the barrel of the bat. The transitional member may provide for vibration and/or shock dampening to minimize or eliminate the “sting” typically associated with monolithic, metallic bats. Additionally, the handle may include a shape that tends to naturally align the vertical and swing planes of the bat when the handle is gripped by a player. | 2012-05-31 |
20120135827 | BASEBALL BAT - Baseball bats described herein may have handle, throat and/or barrel portions that include non-circular cross-sections. | 2012-05-31 |
20120135828 | Panel Configuration for a Game Ball - A game ball, which may be a soccer ball or a variety of other types of ball. The game ball includes a plurality of pentagonal panels, with each of the pentagonal panels having five convex edges. The game ball also includes a plurality of hexagonal panels, with each of the hexagonal panels having three substantially linear edges and three concave edges. The pentagonal panels and the hexagonal panels are connected along abutting concave edges and convex edges, and the hexagonal panels are connected each other along abutting linear edges. | 2012-05-31 |
20120135829 | CONTROLLER AND CONTROL METHOD OF BELT TYPE CONTINUOUSLY VARIABLE TRANSMISSION - Provided is control device and method for a belt type continuously variable transmission which can reduce drive energy consumption by a decrease in belt friction when the estimated accuracy of belt slip condition is high and which can prevent the belt from greatly slipping during belt slip control when the estimated accuracy of belt slip condition is low. The device includes a primary pulley ( | 2012-05-31 |
20120135830 | Torsion Cushioning Sprocket - A drive sprocket for machines such as a motorcycle includes cushioning dements to reduce spikes in stress levels between the machine's power transmission and a driven member, such as the wheel of motorcycle. The sprocket has an inner plate which is located coaxially within the outer ring. The inner plate is formed with outwardly projecting lugs that are arranged to mesh with the inwardly projecting lugs of outer ring. The outwardly projecting lugs comprise six wide lugs and six narrow lugs disposed alternately around the outside of the inner ring. The outer edges of outwardly projecting lugs are formed with a bearing slot. In the case of the six wide lugs, their bearing slots cooperate with bearing slots on the inside wall of the outer ring to provide a ball bearing race for bearings. The sides of the lugs are also formed with cushion slots to engage cushioning elements. | 2012-05-31 |
20120135831 | Tensioning Device with a Damping Means Comprising a Minimum Capacity - A tensioning device for a flexible drive means, such as a chain or a belt, includes a housing, a tensioning piston movably arranged in the housing and provided with a hollow space, a pressure chamber for hydraulic fluid arranged between the housing and the tensioning piston, a vent opening arranged in the tensioning piston, and a damping means in flow communication with the vent opening and with the pressure chamber. A packing element is arranged in the hollow space of the tensioning piston and is at least a component of the damping means, such that the damping means comprises a capacity for hydraulic fluid which corresponds to at least 30% of the volume of the pressure chamber added in a 1 mm stroke of the tensioning piston in the extension direction. The device relates to a series of tensioning devices as well as a transmission and a series of transmissions. | 2012-05-31 |
20120135832 | CHAIN TENSIONER DEVICE - A chain tensioner device having a first slide surface of a main arm pivotably supported at an upper end thereof, and a second slide surface of a sub-arm pivotably supported at a lower end thereof. The first and second slide surfaces slidably abut against each other. When the main arm is biased toward a timing chain via the sub-arm by a biasing force of a plunger of a tensioner lifter, a stroke of the main arm is increased with respect to a stroke of the plunger. | 2012-05-31 |
20120135833 | ELECTRICAL DRIVE APPARATUS FOR VALVES - An electrical drive apparatus for valves includes: a main body having an internal first receiving space in which a transmission unit is received; a drive unit disposed on one side of the main body for driving the transmission unit to rotate; a hand wheel fixed with a top section of the transmission unit, a lower section of the hand wheel being formed with several sockets; and a switch unit for controlling whether the hand wheel and the first transmission shaft can be rotated so as to switch the electrical drive apparatus between an electrical drive operation mode and a manual drive operation mode. | 2012-05-31 |
20120135834 | MULTI-RATIO TRANSMISSION - A multi step transmission comprising planetary gearsets (P | 2012-05-31 |
20120135835 | MULTI-RATIO TRANSMISSION - A multi step transmission comprising planetary gearsets (P | 2012-05-31 |
20120135836 | HYBRID VEHICLE AND HYBRID POWER SYSTEM - An operation method of a hybrid vehicle having an automatic manual transmission system adapted to use at least two energy sources is provided with the following steps. Engaging an engine with a starter generator motor such that the engine and the starter generator motor rotate synchronously. Performing a speed changing by using a control unit assembly through controlling rotation speed of the traction motor and a rotation speed of the starter generator motor to a desired rotation speed for the speed changing according to a running state of the vehicle, such that the engine and the traction motor nearly rotate synchronously with the automatic manual transmission system to perform a gear ratio shifting process thereby to perform the speed changing. Controlling an automatic-switching clutch to engage or disengage the engine and the traction motor to achieve a plurality of driving mode for the vehicle. | 2012-05-31 |
20120135837 | VEHICLE CONTROL SYSTEM AND CONTROL METHOD THEREOF - A time required until the friction element is completely engaged is delayed when a switch from a non-driving position to a driving position is detected or when the engine automatic stop condition no longer holds until the differential rotation of the friction element disappears after the engine automatic stop condition holds as compared with the case where the switch from the non-driving position to the driving position is detected or the engine automatic stop condition no longer holds after the differential rotation of the friction element disappears. | 2012-05-31 |
20120135838 | METHOD FOR OPERATING A TRANSMISSION DEVICE OF A VEHICLE DRIVETRAIN - A method of operating a transmission of a vehicle drive-train that comprises frictional shifting elements and an interlocking shifting element. In the neutral operating condition of the transmission, and in the case of an operating condition variation of the vehicle drive-train in which, when it is required to establish the force flow in the transmission, the interlocking shifting element is to be changed from a disengaged to an engaged operating condition, by increasing the transmission capacities of at least two frictional shifting elements which have to be engaged for producing the force flow, a rotational speed difference in the area of the interlocking shifting element is determined, and a drive torque of a drive machine is adjusted to a level that brings the speed difference within a predefined range at which the interlocking shifting element is approximately synchronized and can therefore be engaged. | 2012-05-31 |
20120135839 | CONTROLLER OF VEHICLE AND CONTROL METHOD OF VEHICLE - A controller of a vehicle, provided with a coast stop control unit which automatically stops an engine during the travel of a vehicle if coast stop conditions are met during the travel of the vehicle, and the coast stop control unit automatically stops the engine at least if a change amount of acceleration of the vehicle caused by the automatic stop of the engine is predetermined acceleration or less. | 2012-05-31 |
20120135840 | COAST STOP VEHICLE AND CONTROL METHOD FOR COAST STOP VEHICLE - A coast stop vehicle, includes an engine, a transmission arranged between the engine and drive wheels and having a plurality of gear positions, a coast stop starting unit which automatically stops the engine when a coast stop start condition holds during travel, a coast stop releasing unit which automatically starts the engine when a coast stop release condition holds during a coast stop, and a downshifting unit which starts engagement of a frictional engagement element, which realizes a lower gear position than the one when the coast stop release condition holds, before complete explosion of the engine and causes a downshift of the transmission when the coast stop release condition holds. | 2012-05-31 |
20120135841 | COAST STOP VEHICLE AND CONTROL METHOD FOR COAST STOP VEHICLE - A coast stop vehicle includes a hydraulic pressure supplying unit which supplies a hydraulic pressure to the transmission while the engine is stopped, a coast stop start condition judging unit which judges whether or not a coast stop start condition holds, a coast stop control unit which stops the engine when the coast stop start condition is judged to hold by the coast stop start condition judging unit and starts the engine when receiving an acceleration request from a driver during the coast stop, a transmission control unit which causes a downshift of the transmission when receiving the acceleration request from the driver during the coast stop, and a hydraulic control unit which supplies the hydraulic pressure to an after-shift frictional engagement element which realizes a gear position after the downshift of the transmission during the coast stop. | 2012-05-31 |
20120135842 | TRANSLATORY MOTION STRENGTH TRAINING SYSTEM AND METHOD - A strength training apparatus adapted for conducting translatory motion against a counteracting resistance. The apparatus includes strength training devices wherein a carriage and corresponding guide means are provided for translating mass under the effect of gravity along a rectilinear or curvilinear path. Certain embodiments are configured for utilizing a selectable weight stack, loaded free weights or the user's body weight as a primary resistance that is independent of velocity. The apparatus enhances the results of strength training and exercise equipment for providing velocity-dependent resistance in addition to “static” resistance provided by the apparatus at constant velocity. The apparatus includes velocity-dependent resistance provided by eddy current resistance caused by the interaction of an electrically conductive structure encountering relative motion with a magnetic field. The electrically conductive structure is secured to a frame and magnetic field is provided by one or more permanent magnets secured to the carriage. | 2012-05-31 |
20120135843 | INTEGRATED PUNCHING BAG SYSTEM - A punching bag base and punching bag assembly. The base provides multiple areas to store exercise accessories such as weighted dumbbells and weighted ankle weights. In one form, the areas formed in the base to receive weights or related exercise equipment form a shape that is complementary to that of the equipment stored in it. In another form, the base can be of a generally hollow construction to accept ballast to provide additional stability of the base when it is placed on a floor or related support structure. The system may also include an integrated hook placed on the pole that allows the user the ability to hang boxing gloves, towels or other exercise equipment. The system may also include a wheel assembly to facilitate ease of movement. | 2012-05-31 |
20120135844 | MULTIFUNCTION DUMBBELL - A multifunction dumbbell includes a handle comprising two projections on both ends respectively; two hollow weight members each comprising a protrusion extending toward the handle; two spacer sleeves each comprising a closed flange fixedly secured to a joining portion of the handle and either projection, the spacer sleeves fixedly fastened between the protrusions and the projections; two rings each having an inner diameter less than an outer diameter of the weight member so that the rings can be put on the weight members and retained thereon respectively; two half-spherical members each fixedly secured to the ring and complimentarily engaged with the weight member; and two truncated conic springs each put on the protrusion and a portion of the weight member to be retained between the spacer sleeve and the ring. The rings and the half-spherical members together are adapted to rotate about the weight members. | 2012-05-31 |
20120135845 | PLASTIC BAG MAKING APPARATUS - Upon cutting a corner of a plastic bag, the cut-out portion is prevented from attaching to the plastic bag. A plastic film ( | 2012-05-31 |
20120135846 | Centrifuge - The present invention provides a centrifuge capable of adjusting a temperature of a material. | 2012-05-31 |
20120135847 | METHOD AND APPARATUS FOR CUTTING A BRITTLE-MATERIAL SUBSTRATE, AND WINDOW GLASS FOR VEHICLE OBTAINED BY THE METHOD - A method for cutting a brittle-material substrate by irradiating a converged laser beam on a brittle-material substrate along first and second cutting lines intersecting each other at least at one point, includes forming scribe lines along the first and the second cutting lines on a surface of the brittle-material substrate, and relatively moving an irradiation position of the laser beam on the surface of the brittle-material substrate along the scribe lines to cut the brittle-material substrate at a forward position of the irradiation position in the moving direction of the irradiation position. The irradiation of the laser beam is limited in a region in the vicinity of an intersection where the first and the second cutting lines intersect. | 2012-05-31 |
20120135848 | FUSION FORMED AND ION EXCHANGED GLASS-CERAMICS - The present disclosure relates to fusion formable highly crystalline glass-ceramic articles whose composition lies within the SiO | 2012-05-31 |
20120135849 | MODULUS, LITHIUM FREE GLASS - An R-glass composition including SiO | 2012-05-31 |
20120135850 | PERGALLOUS ALKALINE EARTH SELENOGERMANATE GLASSES - IR-transmitting alkaline earth selenogallo- and/or selenoindo-germanate glasses that are capable of hosting luminescent rare earth dopants. The relatively high Ga and/or In content of most compositions serves to eliminate the typical clustering tendency of rare earth dopants in chalcogenide glasses, resulting in improved luminescence. | 2012-05-31 |
20120135851 | HIGH TRANSMITTANCE LIGHT-COLORED GLASS AND PROCESS FOR PRODUCING THE GLASS - To provide a high transmittance light-colored glass having a high Tva (at least 60%), a low Te (at most 60%), a low Pe (at most 6.0%) and λd of from 560 to 780 nm or λc of from −550 to −492 nm. A high transmittance light-colored glass comprising, as a glass matrix composition, SiO | 2012-05-31 |
20120135852 | ALKALINE EARTH ALUMINO-BOROSILICATE CRACK RESISTANT GLASS - The present disclosure relates to glass articles for use as a touchscreen substrate or cover glass article for use in a portable electronic device, particularly an aluminoborosilicate glass being substantially free of alkalis, comprising at least 55 mol % SiO | 2012-05-31 |
20120135853 | GLASS ARTICLES/MATERIALS FOR USE AS TOUCHSCREEN SUBSTRATES - The present disclosure relates to glass articles for use as a touchscreen substrate for use in a portable electronic device, particularly comprising an alkali-free aluminosilicate glass exhibiting a high damage threshold of at least 1000gf, as measured by the lack of the presence of median/radial cracks when a load is applied to the glass using a Vickers indenter, a scratch resistance of at least 900gf, as measured by the lack of the presence of lateral cracks when a load is applied by a moving Knoop indenter and a linear coefficient of thermal expansion (CTE) over the temperature range 0-300° C. which satisfies the relationship: 25×10−7/° C.≦CTE≦40×10−7/° C. | 2012-05-31 |
20120135854 | Method of Forming Porous Ceramic Articles Using Inert Gas - A method of manufacturing a porous ceramic article is provided that includes injecting a gas into a precursor batch material. The gas is pressurized to a positive gauge pressure. Exemplary gasses that can be injected into the precursor batch material include at least one of nitrogen, helium, neon, argon, krypton, and xenon. Air can also be injected into the precursor batch material, including air in which at least a portion of CO | 2012-05-31 |
20120135855 | TITANIUM-BASED MATERIAL HAVING VISIBLE LIGHT RESPONSE AND EXCELLENT IN PHOTOCATALYTIC ACTIVITY AND METHOD OF PRODUCTION OF SAME - The provision of beautiful colored titanium which is excellent in adhesion of the pure titanium or a titanium alloy with the base material, is excellent in photocatalytic activity, and further is excellent in design properties and a method of production of the same which is excellent in productivity and uses an anodic oxidation process is made the object. A titanium-based material having visible light response and excellent in photocatalytic activity characterized in that the material has pure titanium or titanium alloy as a base material, a thickness of a titanium oxide layer which is present on its surface is 0.1 μm to 5.0 μm in range, said titanium oxide layer contains anatase-type titanium dioxide and titanium bonded with hydroxy groups, and further said titanium oxide layer contains nitrogen and carbon respectively in 0.5 to 30 mass %. | 2012-05-31 |
20120135856 | PROCESS FOR REGENERATING A DEACTIVATED HETEROPOLYMOLYBDOPHOSPHORIC ACID CATALYST - The present invention provides a process for regenerating a deactivated heteropolymolybdophosphoric acid catalyst, comprising the steps of grinding the deactivated catalyst into particles having a particle size of 40 mesh or less, mixing the particles with a mixture comprising aqua ammonia, which is an aqueous solution containing ammonium ions and organic auxiliaries, kneading the mixture of particles and aqua ammonia in a kneader to obtain a paste, drying the paste, molding the paste into cylindrical particles with a through hole in its longitudinal axis, and heating the paste in atmosphere at 350˜450° C. for 1˜10 hours to produce the generated catalyst. | 2012-05-31 |
20120135857 | NOVEL ORGANOMETALLIC COMPOUNDS CONTAINING A METAL BELONGING TO THE SECOND COLUMN OF THE PERIODIC TABLE, AND METHOD FOR PREPARING SAME - The present invention relates to a novel organometallic compound based on a divalent metal belonging to the 2 | 2012-05-31 |
20120135858 | CATALYST AND METHODS FOR PRODUCING MULTI-WALL CARBON NANOTUBES - The present invention provides a catalyst precursor and a catalyst suitable for preparing multi-wall carbon nanotubes. The resulting multi-wall carbon nanotubes have a narrow distribution as to the number of walls forming the tubes and a narrow distribution in the range of diameters for the tubes. Additionally, the present invention provides methods for producing multi-wall carbon nanotubes having narrow distributions in the number of walls and diameters. Further, the present invention provides a composition of spent catalyst carrying multi-wall nanotubes having narrow distribution ranges of walls and diameters. | 2012-05-31 |
20120135859 | HIGHLY EFFICIENT CATALYST USING PRECIOUS METAL - A catalyst for purifying exhaust gas in vehicles may include a precious metal and porous structures that serve as a supporting material for the precious metal. The porous structures are comprised of a plurality of channels which are connected with each other by a plurality of bridges. The channels may have multiple entrances that allow reactants to pass through and react with the precious metal. | 2012-05-31 |
20120135860 | CATALYST PREPARATION METHOD - A method for preparing a catalyst comprising (i) preparing a calcined shaped calcium aluminate catalyst support, (ii) treating the calcined shaped calcium aluminate support with water, and then drying the support, (iii) impregnating the dried support with a solution containing one or more metal compounds and drying the impregnated support, (iv) calcining the dried impregnated support, to form metal oxide on the surface of the support and (v) optionally repeating steps (ii), (iii) and (iv) on the metal oxide coated support. The method provides an eggshell catalyst in which the metal oxide is concentrated in an outer layer on the support. | 2012-05-31 |
20120135861 | PHOTOCATALYTIC MATERIALS AND PROCESS FOR PRODUCING THE SAME - The present invention relates to a photocatalytic material having a visible light activity which includes a tungsten-doped titanium oxide or a tungsten/gallium-codoped titanium oxide, and a divalent copper salt and/or a trivalent iron salt supported on a surface of the doped or codoped titanium oxide, and a process for producing the photocatalytic material. | 2012-05-31 |
20120135862 | METHODS OF PREPARING ELECTROCATALYSTS FOR FUEL CELLS IN CORE-SHELL STRUCTURE AND ELECTROCATALYSTS - Provided are a method of preparing an electrocatalyst for fuel cells in a core-shell structure, an electrocatalyst for fuel cells having a core-shell structure, and a fuel cell including the electrocatalyst for fuel cells. The method may be useful in forming a core and a shell layer without performing a subsequent process such as chemical treatment or heat treatment and forming a core support in which core particles having a nanosize diameter are homogeneously supported, followed by selectively forming shell layers on surfaces of the core particles in the support. Also, the electrocatalyst for fuel cells has a high catalyst-supporting amount and excellent catalyst activity and electrochemical property. | 2012-05-31 |
20120135863 | COMPOSITION AND METHOD FOR PROMOTING PLANT ROOT GROWTH - The present invention provides a composition comprising, as active ingredients, 4-oxo-4-[(2-phenylethyl)amino]-butyric acid and an amide compound of the formula (1); and so on. | 2012-05-31 |
20120135864 | POLLINATION IMPROVER - A composition suitable for improving seed quality in a plant comprising:
| 2012-05-31 |
20120135865 | PESTICIDE FORMULATION WITH STREAMING BIREFRINGENCE - A pesticide composition exhibiting streaming birefringence and methods for making the pesticide composition are disclosed. In one embodiment, the pesticide composition comprises an active ingredient and a surfactant adjuvant. | 2012-05-31 |
20120135866 | INCREASING PLANT VIGOR - Compositions and processes for improving plant vigor are disclosed. | 2012-05-31 |
20120135867 | INPUT/OUTPUT SYSTEM AND DEVICES FOR USE WITH SUPERCONDUCTING DEVICES - An I/O system and device for use with superconducting device provides multi-stage filtering using superconducting electrical pathways, while providing good thermal conductivity to maintain low temperature of the various components and allowing the easy mounting and dismounting of a device sample from a refrigerated environment. Filtering may include a lumped element filter assembly including multiple plates each carrying a number of lumped element filters. Filtering may include a metal powder filter assembly including multiple metal power filters formed in passages of a substantially non-magnetic portions. A device sample holder assembly secures a device sample, for example a superconducting quantum processor, and provides signals, ground and good thermal conduction. | 2012-05-31 |
20120135868 | SUPERCONDUCTING MAGNET ASSEMBLY AND FABRICATING METHOD - A superconducting magnet assembly includes a bobbin comprising a central bore along a longitudinal direction, and a superconducting coil package wound on the bobbin. The superconducting coil package includes a plurality of superconducting coil layers wound on the bobbin, a plurality of supporting member layers, each of the supporting member layers being between a corresponding two adjacent superconducting coil layers, and a thermal conduction layer between two superconducting coil layers or between a superconducting coil layer and an adjacent supporting member layer. | 2012-05-31 |
20120135869 | IRON-BASED SUPERCONDUCTING WIRE AND METHOD FOR PRODUCING THE SAME - Disclosed is an iron-based superconducting wire comprising a tubular material formed mainly from iron, and an iron-based superconductor formed in the tubular material, wherein the iron-based superconductor contains the iron forming the tubular material as a chemical constituent element of the iron-based superconductor. | 2012-05-31 |
20120135870 | Methods and Apparatus for Measuring Analytes Using Large Scale FET Arrays - Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis. | 2012-05-31 |
20120135871 | HIGH THROUGHPUT DETECTION OF MOLECULAR MARKERS BASED ON AFLP AND HIGH THROUGH-PUT SEQUENCING - The present invention relates to a high throughput method for the identification and detection of molecular markers wherein restriction fragments are generated and suitable adaptors comprising (sample-specific) identifiers are ligated. The adapter-ligated restriction fragments may be selectively amplified with adaptor compatible primers carrying selective nucleotides at their 3′ end. The amplified adapter-ligated restriction fragments are, at least partly, sequenced using high throughput sequencing methods and the sequence parts of the restriction fragments together with the sample-specific identifiers serve as molecular marker. | 2012-05-31 |
20120135872 | METHODS OF FETAL ABNORMALITY DETECTION - Methods and kits for selectively enriching non-random polynucleotide sequences are provided. Methods and kits for generating libraries of sequences are provided. Methods of using selectively enriched non-random polynucleotide sequences for detection of fetal aneuploidy are provided. | 2012-05-31 |
20120135873 | GENOME DETERMINATION ASSAY - The present invention relates to a genome determination assay and method for detecting and cleaving a target non-amplified genomic nucleic acid sequence at two or more genomic nucleic acid sequence sites simultaneously, using a mismatch repair enzyme selected from the group consisting of TDG and Mut Y. The method may be used to detect a species under non-lab conditions and identify a DNA sequence utilizing the specificity of the base excision repair (BER) system enzymes. It may also be used to cleave a specific genomic sequence of choice. Currently, genomic DNA is only cleaved with restriction enzymes at restriction sites. As one example, chicken genome specific sequences are utilized to determine chick gender, without the use of standard assays, such as PCR or Fluorescent In Situ Hybridization (FISH). TDG, a Base Excision Repair (BER) enzyme that restores T/G mismatches to C/G at sites of 5-methylcytosine deamination, is used to detect, bind and function on a primer hybridized to genomic DNA template. The primer sequence may contain a T to mismatch a G in the target genomic DNA sequence or, symmetrically, the mismatch may be reversed so that the primer sequence may contain a G to mismatch a Tin the target genomic DNA sequence, and the T/G is cleaved with high fidelity. | 2012-05-31 |
20120135874 | SINGLE MOLECULE SPECTROSCOPY FOR ANALYSIS OF CELL-FREE NUCLEIC ACID BIOMARKERS - The present invention relates, e.g., to a method for detecting a nucleic acid molecule of interest in a sample comprising cell-free nucleic acids, comprising fluorescently labeling the nucleic acid molecule of interest, by specifically binding a fluorescently labeled nanosensor or probe to the nucleic acid of interest, or by enzymatically incorporating a fluorescent probe or dye into the nucleic acid of interest, illuminating the fluorescently labeled nucleic acid molecule, causing it to emit fluorescent light, and measuring the level of fluorescence by single molecule spectroscopy, wherein the detection of a fluorescent signal is indicative of the presence of the nucleic acid of interest in the sample. | 2012-05-31 |
20120135875 | METHODS FOR DETERMINING SENSITIVITY TO VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 MODULATORS - VEGFR-2 biomarkers useful in a method for identifying and monitoring a mammal that will respond therapeutically to a method of treating cancer comprising administering an VEGFR-2 modulator, wherein the method comprises (a) exposing the mammal to the VEGFR-2 modulator and (b) measuring in the mammal the level of the at least one biomarker, wherein a difference in the level of the at least one biomarker measured in (b) compared to the level of the biomarker in a mammal that has not been exposed to the VEGFR-2 modulator indicates that the mammal will respond therapeutically to the method of treating cancer and (c) wherein the level of the biomarker in a mammal after exposure to a VEGFR-2 modulator indicates that the mammal has responded therapeutically to the method of treating cancer. | 2012-05-31 |
20120135876 | HIGH-THROUGHPUT ASSAY METHODS AND ARTICLES - An assay device and method of use thereof, include a multiwell chip and a microarray slide printed with capture molecules. The chip contains shallow wells for holding liquid samples and, optionally, shoulders for receiving the slide. The slide, when placed on the chip, can contact the top of the liquid sample and draw the liquid sample upwards onto the capture molecules. The microarray slide and multiwell chip are capable of forming a closed incubation chamber preventing outside contamination and liquid evaporation. Patterning of the slide can be carried out by direct write lithography or nanolithography, including DPN printing. Small liquid volumes can be used. | 2012-05-31 |
20120135877 | DNA Methylation Markers For Prostate Cancer Field Defect - A method of detecting the presence of a prostate cancer field defect in a human subject comprising the step of (a) obtaining genomic DNA from the human subject and (b) quantitating methylation in at least one target region selected from the group consisting of CAV1, EVX1, MCF2L, FGF1, NCR2 and WNT2 target, wherein significant methylation changes indicate the presence of prostate cancer or a prostate cancer field defect, wherein the change is relative to tissue from a second human subject who does not have prostate cancer. | 2012-05-31 |
20120135878 | Generation of Neural Stem Cells from Human Trophoblast Stem Cells - Provided herein are isolated neural stem cells. Also provided are methods for treatment of neurodegenerative diseases using suitable preparations comprising the isolated neural stem cells. | 2012-05-31 |
20120135879 | Method and Composition for Cancer Diagnosis and Treatment - Methods and compositions for inhibiting the onset of cancer, and cancer diagnosis and treatment are provided. The treatment method comprises inhibiting the level or function of transcriptional positive factor 4 (PC4). Also provided are methods of screening for cancer inhibition agents based on inhibition of PC4 expression or function. | 2012-05-31 |
20120135880 | Crystal of Human Glycoprotein VI Collagen Binding Domain - A crystal comprising the collagen binding domain of human GPVI is provided and defined by structural atomic coordinates. Employing computer modeling based on the crystal structure, including methods for identifying inhibitors of GPVI collagen binding activity, methods for screening libraries of compounds for potential to bind to the GPVI collagen binding domain, and methods of identifying a compound useful for the treatment of a GPVI-mediated disorder, are also provided. | 2012-05-31 |
20120135881 | MARKERS FOR DETECTION OF GASTRIC CANCER - Early detection of tumors is a major determinant of survival of patients suffering from tumors, including gastric tumors. Members of the GTM gene family can be differentially expressed in gastric tumor tissue, and thus can be used as markers for the detection of gastric and other types of cancer. The present invention provides for novel GTMs for the detection of tumors, including gastric tumors, and in particular human zymogen granule protein 16 (ZG16). The GTMs can be used in isolation or together with other known GTMs to provide for novel signatures to be used in the detection of tumors, including gastric tumors. | 2012-05-31 |
20120135882 | METHODS FOR DIAGNOSING CHRONIC KIDNEY DISEASE AND ASSESSING THE RISK OF DISEASE PROGRESSION - Methods and compositions for diagnosing chronic kidney disease and assessing the risk of disease progression, as well as methods of screening for molecular biomarkers useful for diagnosing the likelihood of disease progression, are provided. | 2012-05-31 |
20120135883 | MULTIVALENT OPSONOPHAGOCYTIC ASSAY USING BEAD ARRAY AND IMAGING - Embodiments of the present invention relate to devices and methods for detecting opsonophagocytotic antibodies using detection particles having product-specific detection reagents and having a characteristic spectral feature. Detection substrates, include microwells. Phagocytic cells are grown in the microwells, and a sample of serum or other bodily fluid from a patient is introduced into the wells, along with a set of detection particles, each set having an antigen recognized by opsonophagocytotic antibodies. The detection particles bind to the antibodies present in the sample and the phagocytic cells then take up the detection particles, labeling the phagocytic cells. The cells are then visualized via image analysis, thereby detecting the presence of, and the types of the opsonophagocytotic antibodies in the sample. | 2012-05-31 |
20120135884 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING MACULAR DEGENERATION - The present invention relates generally to biomarkers for macular degeneration. In particular, the present invention provides a plurality of biomarkers for monitoring and diagnosing macular degeneration. The compositions and methods of the present invention find use in diagnostic, therapeutic, research, and drug screening applications. | 2012-05-31 |
20120135885 | Methods and Kits Using Extended Rhodamine Dyes - Extended rhodamine compounds exhibiting favorable fluorescence characteristics having the structure | 2012-05-31 |
20120135886 | METHOD FOR DETECTION OF, OR THE RISK OF, BLADDER CANCER - The present invention provides a method for the detection of or the risk of bladder cancer in a patient, comprising the step of detecting the presence of a combination of at least two biomarkers selected from CEA, VEGF, IL-8, NGAL, NSE, IL-2, EGF, TM, d-Dimer, MMP-9, IL-6, IL-4, MMP-9/NGAL, FAS, CRP, TUP and NMP22 in one or more samples isolated from a patient wherein the presence of a combination of at least two biomarkers in the one or more samples indicates the presence or risk of bladder cancer. | 2012-05-31 |
20120135887 | CELL HANDLING, ELECTROPORATION AND ELECTROFUSION IN MICROFLUIDIC SYSTEMS - Method and systems provide improved cell handling in microfluidic systems and devices using lateral cell trapping and methods of fabrication of the same that allow for selective low voltage electroporation and electrofusion. | 2012-05-31 |
20120135888 | METHOD FOR PREDICTING THE RESPONSE OF LOCALLY ADVANCED RECTAL CANCER TO CHEMORADIOTHERAPY - The present invention relates to a method for determining or predicting the response of a patient diagnosed with locally advanced rectal cancer to chemoradiotherapy. The present invention also aims to provide methods and devices for predicting the response of patients diagnosed with rectal cancer to specific medicaments, radiotherapy and/or chemotherapy. More specifically, the present invention provides methods which measure kinase activity by studying phosphorylation levels and profiles in samples of said patients. | 2012-05-31 |
20120135889 | METHODS AND COMPOSITIONS FOR IMPROVED FERTILIZATION AND EMBRYONIC SURVIVAL - Single nucleotide polymorphic site at position 11646 of the bovine FGF2 gene is associated with improved fertilization rate and/or improved embryo survival rate, as well as improved milk production. Also disclosed are nucleic acid molecules, kits, methods of genotyping and marker assisted bovine breeding methods. | 2012-05-31 |
20120135890 | BIOMOLECULE ARRAY AND METHOD OF FABRICATING BIOMOLECULE ARRAY CHIP USING THE SAME - Disclosed are a biomolecule array and a method of fabricating a biomolecule array chip using the same. The present disclosure provides a simple method of fabricating a biomolecule array chip by coupling a pillar array with a well array The pillar array is provided with pillars protruded from a surface of a substrate, having a predetermined size and being arranged at a predetermined interval and is configured to apply biomolecules to a top surface of a pillar and the well array is configured so that each pillar formed in the pillar array is inserted into each well of the well array corresponding one-to-one after the biomolecule solutions are injected into each well. | 2012-05-31 |
20120135891 | METHODS AND DEVICES FOR EARLY DETECTION OF CANCER CELLS AND TYPES THROUGH MICROMECHANICAL INTERACTIONS - Methods and devices for detecting a cancer cell and cancer cell types in a sample of a subject are provided. | 2012-05-31 |
20120135892 | siRNA targeting spleen tyrosine kinase - Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rationale design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. | 2012-05-31 |
20120135893 | High throughput genome sequencing on DNA arrays - The present invention is directed to methods and compositions for acquiring nucleotide sequence information of target sequences using adaptors interspersed in target polynucleotides. The sequence information can be new, e.g. sequencing unknown nucleic acids, re-sequencing, or genotyping. The invention preferably includes methods for inserting a plurality of adaptors at spaced locations within a target polynucleotide or a fragment of a polynucleotide. Such adaptors may serve as platforms for interrogating adjacent sequences using various sequencing chemistries, such as those that identify nucleotides by primer extension, probe ligation, and the like. Encompassed in the invention are methods and compositions for the insertion of known adaptor sequences into target sequences, such that there is an interruption of contiguous target sequence with the adaptors. By sequencing both “upstream” and “downstream” of the adaptors, identification of entire target sequences may be accomplished. | 2012-05-31 |
20120135894 | METHODS AND COMPOSITIONS FOR DETERMINATION OF FRACTURE GEOMETRY IN SUBTERRANEAN FORMATIONS - Disclosed herein is a method comprising disposing in a formation fracture, a proppant and/or a fracturing fluid that comprises a radiation susceptible material that comprises indium and/or vanadium; irradiating the radiation susceptible material with neutrons; measuring gamma-radiation emitted from the radiation susceptible material in a single pass; wherein the single pass does not involve measuring of background radiation from previous or subsequent logging passes; and determining formation fracture height from the measured gamma-radiation. | 2012-05-31 |
20120135895 | Compositions and Methods Relating to the Stabilization of Hydrophobically Modified Hydrophilic Polymer Treatment Fluids Under Alkaline Conditions - The present invention relates to methods and compositions for treating a water- and hydrocarbon-producing subterranean formation with a relative permeability modifier, and more specifically, to improved treatment fluids, methods for preparing treatment fluids, and methods for use thereof in a subterranean formation. Methods of the present invention comprise providing a treatment fluid comprising a relative permeability modifier, at least one surfactant, and an aqueous phase base fluid; and placing the treatment fluid in a subterranean formation. The relative permeability modifier comprises a hydrophobically modified hydrophilic polymer. The at least one surfactant is operable to maintain the relative permeability modifier in a dissolved state in the treatment fluid above a pH of about 8. | 2012-05-31 |
20120135896 | Compositions and Methods for Controlling Fluid Loss - Alkaline earth metal compounds may be fluid loss control (FLC) agents for viscoelastic surfactant (VES) fluids used for fluid loss control pills, lost circulation material pills and kill pills in hydrocarbon recovery operations. The FLC agents may include, but not be limited to oxides and hydroxides of alkaline earth metal, and in one case magnesium oxide where the particle size of the magnesium oxide is between 1 nanometer to 0.4 millimeter. The FLC agent may alternatively be transition metal oxides and/or transition metal hydroxides. The FLC agent appears to associate with the VES micelles and together form a novel pseudo-filter cake quasi-crosslinked viscous fluid layer that limits further VES fluid flow into the porous media. The FLC agent solid particles may be added along with VES fluids. The pills may also contain internal breakers to reduce the viscosity thereof so that the components of the pill may be recovered. | 2012-05-31 |
20120135897 | Lubricant of solid or liquid consistency, exhibiting low viscosity ratio - The invention relates to a lubricant in the form of grease or thick lubricating gel or transmission oil, as well as motor or universal oils with a myriad of applications. As a result of its contents presented in the patent application is characteristic of low coefficient of friction ranging from 0.055 to 0.062. As the main component, the contents of the discussed lubricant includes three or four stearates of metals or hydroxistearates of metals, which interact and cause a noticeable reduction of friction drag on the lubricated surfaces. Additionally, these substances may include a number of other solid or liquid elements, which maintain low friction drags and, furthermore, improve the lubricant through increasing its load capacity, antirust characteristics, shear strength, etc. The lubricant made according to the invention underwent comparative tests against other greases and greasing oils, the accounts of which are included in the application as diagrams, descriptions of research tests and examples of the contents of the lubricant products. | 2012-05-31 |
20120135898 | Multi-Dispersant Lubricating Composition - The present invention relates to a lubricating composition containing a corrosion inhibitor compound and a mixture of two or more dispersants, wherein 0 mole % to less than 50 mole % of the second dispersant molecules contain a carbocyclic ring. The invention further provides a method for lubricating a mechanical device using the lubricating composition. | 2012-05-31 |
20120135899 | Lubricating Composition Containing Friction Modifier and Viscosity Modifier - A lubricant composition suitable for lubricating an internal combustion engine comprises: (a) an oil of lubricating viscosity having a viscosity index of at least 105 and a kinematic viscosity at 100 C of less than 7 mm2s-1; (b) 0.01 to 2 weight percent of a friction modifier represented by the structure [I]; (c) 0.5 to 4 weight percent of a poly(meth)acrylate viscosity modifier polymer; (d) 0 to 500 parts per million by weight of molybdenum in the form of an oil-soluble molybdenum compound; and (e) 0 to 200 parts per million by weight of boron in the form of an oil-soluble boron compound. | 2012-05-31 |
20120135900 | LUBRICANT OIL COMPOSITION AND METHOD FOR MAKING THE SAME - The lubricating oil composition of the invention comprises a lubricating base oil with a kinematic viscosity at 100° C. of 1-20 mm | 2012-05-31 |
20120135901 | LUBRICATING OIL COMPOSITION - A low sulphated ash lubricating oil composition comprises an ashless aromatic amine antioxidant and an overbased magnesium detergent which exhibits improved thermal oxidation stability. | 2012-05-31 |
20120135902 | Polymethacrylates as High VI Viscosity Modifiers - A lubricating composition contains an oil of lubricating viscosity and 0.5 to 10 percent by weight of a poly (meth)acrylate viscosity modifier polymer comprising (i) 15 weight percent to 35 weight percent monomer units of methyl (meth) acrylate, (ii) 0 to 10 weight percent monomer units of one or more C | 2012-05-31 |
20120135903 | LUBRICATING OIL COMPOSITION - A lubricating oil composition comprising: boron atoms from about 5-75 ppm; and 100% by mass being (i) 90 to 10% of a (co)polymer of specified kinematic viscosity and acid values, primarily derived from 1-decene, (ii) 5 to 85% of a (co)polymer having specified kinematic viscosity and molecular weight distribution, mostly derived from 1-octene, and (iii) 5 to 15% of a fatty acid ester. | 2012-05-31 |
20120135904 | LUBRICANT COMPOSITION - A lubricant oil composition which is excellent in wear resistance, high temperature detergency and base number retaining property, despite its low phosphorus content, low sulfur content and low sulfuric acid ash content, is provided at a low cost by compounding a sulfonamide compound having a specific structure in a base oil. | 2012-05-31 |
20120135905 | Aerosol Electrical Contact Cleaning and Lubricating Compound - An aerosol electrical contact cleaning and lubricating compound formulation including a first solvent, a second solvent, a third solvent, a lubricant, and a propellant. The first solvent is a mixture of methyl nanofluoroisobutyl ether and methyl nanofluorobutyl ether. The second solvent is a dichloroethylene, while the third solvent is an alkyl cyclohexane. The lubricant is perfluropolyether oil, and the propellant is a hydrofluorocarbon liquefied gas. | 2012-05-31 |
20120135906 | DEINKING A CELLULOSIC SUBSTRATE USING MAGNESIUM SILICATE - A composition and method for deinking is disclosed. The composition and method contain an activated magnesium silicate or a magnesium silicate. | 2012-05-31 |
20120135907 | DEINKING A CELLULOSIC SUBSTRATE USING MAGNESIUM HYDROXIDE - A composition and method for deinking is disclosed. The composition and method contain an activated magnesium hydroxide or a magnesium hydroxide. | 2012-05-31 |
20120135908 | DEINKING A CELLULOSIC SUBSTRATE USING MAGNESIUM HYDROXIDE - A composition and method for deinking is disclosed. The composition and method contain an activated magnesium hydroxide or a magnesium hydroxide. | 2012-05-31 |
20120135909 | CLEANING COMPOSITIONS AND METHODS FOR BURNT-ON FOOD AND OIL RESIDUES - Disclosed herein are compositions comprising a solubilizing agent for the removal of burnt-on, cooked-on, baked-on, dried-on and charred organic food and oil residues from surfaces comprising alcohol, a coupling agent, water, an anti-deposition agent, a pH buffer and a surfactant system that preferably includes a fermentation supernatant, where the supernatant contains essentially stress proteins. Further enclosed are methods of cleaning for ovens, industrial cooking equipment and the like. | 2012-05-31 |
20120135910 | Aqueous Laundry Liquid Suitable for Packaging in Polyvinyl Alcohol Pouches - The present invention relates to a liquid cleaning composition comprising (i) at least one nonionic surfactant, (ii) at least one anionic surfactant, (iii) at least one non-aqueous solvent, and (iv) water, characterized in that the water content of the composition is below 10% by weight, and the composition is free of volatile organic compounds (VOCs). In addition, water-soluble packages such as pouches or sachets, containing the liquid cleaning composition, are provided. | 2012-05-31 |
20120135911 | Acetylation of Chitosan - A process for making modified N-acetylated chitosan comprising the steps of:
| 2012-05-31 |
20120135912 | POLYPEPTIDE INHIBITORS OF VLA4 - The invention provides novel 2D-VCAM-1 variant polypeptides and conjugates thereof that bind human VLA4. The invention also provides related polynucleotides, compositions, vectors, host cells, and methods. | 2012-05-31 |
20120135913 | LYSINE COMPOUNDS AND THEIR USE IN SITE- AND CHEMOSELECTIVE MODIFICATION OF PEPTIDES AND PROTEINS - The present invention concerns new thiolysine and selenolysine compounds that can be used as building blocks for peptides and proteins, providing ligation handles for site- and chemoselective modification of said peptides and proteins. In particular, the invention provides. In particular, the invention provides (the use of) the compounds 5-thiolysine (also referred to as δ-thiolysine); 4-thiolysine (also referred to as γ-thiolysine); 5-selenolysine (also referred to as δ-selenolysine) and 4-selenolysine (also referred to as γ-selenolysine). The positioning of the thiol or selenol group at the respective carbon atom allows for a very efficient intramolecular transfer reaction to take place after conjugation with a selected ligand, and the thiol or selenol group may subsequently be removed using reported procedures, thereby restoring the native lysine structure, or be used as an additional conjugation handle. The methodology is fast and gives well-defined material. | 2012-05-31 |
20120135914 | ETOPOSIDE AND DOXORUBICIN CONJUGATES FOR DRUG DELIVERY - The invention relates to improvements in the field of drug delivery. More particularly, the invention relates to polypeptides having a hydrolyzable covalent bond to a therapeutic agent that includes, etoposide, etoposide 4′-dimethylglycine or doxorubicin. These polypeptide conjugates can be used as vectors to transport the podophyllotoxin derivative across the blood brain barrier (BBB) or into particular cell types such as ovary, liver, lung, or kidney. The invention also relates to pharmaceutical compositions that include the compounds of the invention and to uses thereof in methods of treatment. | 2012-05-31 |
20120135915 | TREATMENT OF TRAUMATIC OR DEGENERATIVE NEUROLOGIC, OTOLOGIC, OR OPHTHALMOLOGIC DISEASES WITH TARGETED PROTEASE INHIBITORS - Described herein are compounds and methods for treating or preventing a neurologic, otologic, or ophthalmologic disease in a subject. Also described herein are compounds that can be used as therapeutics. | 2012-05-31 |
20120135916 | MONOMERIC AND DIMERIC FORMS OF ADIPONECTIN RECEPTOR FRAGMENTS AND METHODS OF USE - Methods are disclosed for determining progression of a condition, onset of a condition, or efficacy of treatment of a condition characterized by an adipocyte imbalance in a patient. In addition, methods are disclosed of treating diabetes, abnormal adipocyte activity, and insulin resistance using monomeric, homodimeric, and heterodimeric forms of certain C-terminal fragments of adiponectin receptor. In addition, methods of treating abnormal adipocyte activity, treating metabolic syndrome, causing insulin secretion, increasing insulin levels, inhibiting insulin degradation enzyme, treating Alzheimer's disease, treating cardiovascular disease associated with adiponectin levels, inhibiting ADAM-17 enzyme, inhibiting a protease, treating a condition associated with TNF-alpha, and treating a condition associated with HER2-neu are disclosed. Compositions, dosage forms, and kits are also disclosed. | 2012-05-31 |
20120135917 | Anti-Gram Negative Bacteria Agent - Provided are: a method for blocking the biosynthesis of an outer membrane protein (OMP) necessary for the survival of Gram-negative bacteria by inhibiting the formation of a YaeT complex in the outer membrane of the bacteria and an agent therefor for the purpose of basically solving a problem of the development of multidrug resistance in Gram-negative bacteria. Specifically disclosed is an anti-Gram-negative bacteria agent, wherein the agent exerts a bactericidal action, a growth-inhibiting action, and/or a drug efflux-inhibiting action on Gram-negative bacteria by inhibiting the formation of a YaeT complex. The agent is preferably a peptide molecule comprising an amino acid sequence consisting of at least LTLR or a peptide molecule comprising an amino acid sequence consisting of at least FIRL. | 2012-05-31 |
20120135918 | METHODS OF INHIBITING THE GHRELIN/GROWTH HORMONE SECRETATOGUE RECEPTOR PATHWAY AND USES THEREOF - The invention provides methods for treatment, prevention or management of obesity, obesity related disorders, diabetes mellitus, and metabolic syndrome in a subject by administering a ghrelin O-acyltransferase (GOAT) inhibitor and/or a ghrelin receptor antagonist to the subject. The invention also provides ghrelin receptor antagonists of formula (VII): A | 2012-05-31 |
20120135919 | POLYMER-DRUG CONJUGATES - A conjugate that includes a drug covalently linked to a polymer. Upon administration, the conjugate is digested by an enzyme that is present at the site of administration thereby releasing a therapeutic agent. The conjugate may demonstrate substantially the same pharmacokinetic and pharmacodynamic behavior as the drug itself. A material for controllably releasing a conjugate in response to the local concentration of a molecular indicator. The material includes a plurality of conjugates and a plurality of multivalent cross-linking agents. The polymers of the conjugates include an analog of the indicator within their covalent structure. The multivalent cross-linking agents include cross-link receptors that interact with the indicator analog and thereby cross-link the conjugates. These non-covalent interactions are competitively disrupted when an amount of the molecular indicator is present thereby causing the material to release the conjugate in a manner that is dependent on the local concentration of indicator. | 2012-05-31 |
20120135920 | Preparation Comprising Insulin, Nicotinamide and an Amino Acid - Insulin preparations comprising an insulin compound or a mixture of two or more insulin compounds, a nicotinic compound and an amino acid. | 2012-05-31 |