21st week of 2021 patent applcation highlights part 26 |
Patent application number | Title | Published |
20210155923 | OLIGONUCLEOTIDE ASSEMBLY USING ELECTRICALLY CONTROLLED HYBRIDIZATION - Electrically controlled hybridization is used to selectively assemble oligonucleotides on the surface of a microelectrode array. Controlled activation of individual electrodes in the microelectrode array attracts oligonucleotides in solution to specific regions of the array where they hybridize to other oligonucleotides anchored on the array. The oligonucleotides that hybridize may provide locations for subsequent oligonucleotides to hybridize. The active electrodes and the oligonucleotides in solution may be varied during each round of synthesis. This allows for multiple oligonucleotides each with different and specific sequences to be created in parallel. This is accomplished without the use of phosphoramidite chemical synthesis or template-independent DNA polymerase enzymatic synthesis. Oligonucleotides created with these techniques may be used to encode digital data. Fully assembled oligonucleotides may be separated from the array and sequenced, stored, or otherwise processed. | 2021-05-27 |
20210155924 | METHODS AND COMPOSITIONS FOR INDUCING TUMOR CELL DEATH - The disclosure provides methods and compositions that employ gene editing systems to enable cells to express guide RNAs. Gene editing systems specifically target fusions in tumor DNA to introduce a coding sequence that is expressed by tumor cells as a guide RNA that targets known repetitive elements in the human genome in tumor cells. The CRISPR-like systems are expressed in the tumor cells and cleave the tumor DNA at the known repetitive elements thereby inducing tumor cell death. | 2021-05-27 |
20210155925 | COMPOSITIONS AND METHODS FOR DISRUPTING THE MOLECULAR MECHANISMS ASSOCIATED WITH MITOCHONDRIAL DYSFUNCTION AND NEURODEGENERATIVE DISEASE - Retrotransposons, operating though human-specific neurological pathways, can contribute to environment, lifestyle, and/or age-related neurodegeneration by disrupting functional mitochondrial populations within neurons. The mitochondrial disruption can occur through a number of retrotransposon-induced mechanisms that can influence the efficient and accurate transcription and/or translation of mitochondrial genes encoded in the nuclear genome, operating primarily through epigenetic processes. Alu element-related conformational changes (both subtle and major) of the outer and inner mitochondrial membrane pores can restrict or prevent the normal translocation of proteins (i.e., TOMM and TIMM complexes), ultimately contributing to mitochondrial stress, mitophagy, inflammation, and neuron and glial cell death. Compositions and methods are provided for mitigating and/or preventing Alu element-induced conformational changes to prevent and/or treat neurodegenerative disease and other diseases and disorders associated with at least one TOMM, TIMM, or APOE isoform including cancer and other inflammatory diseases. | 2021-05-27 |
20210155926 | siRNAs WITH AT LEAST TWO LIGANDS AT DIFFERENT ENDS - There is provided inter alia a conjugate for inhibiting expression of a target gene in a cell, said conjugate comprising a nucleic acid portion and ligand portions, said nucleic acid portion comprising at least one duplex region that comprises at least a portion of a first RNA strand and at least a portion of a second RNA strand that is at least partially complementary to the first strand, wherein said first strand is at least partially complementary to at least a portion of RNA transcribed from said target gene, said ligand portions comprising a linker moiety and a targeting ligand for in vivo targeting of cells and being conjugated exclusively to the 3′ and/or 5′ ends of one or both RNA strands, wherein the 5′ end of the first RNA strand is not conjugated, wherein: (i) the second RNA strand is conjugated at the 5′ end to the targeting ligand, and wherein (a) the second RNA strand is also conjugated at the 3′ end to the targeting ligand and the 3′ end of the first RNA strand is not conjugated; or (b) the first RNA strand is conjugated at the 3′ end to the targeting ligand and the 3′ end of the second RNA strand is not conjugated; or (c) both the second RNA strand and the first RNA strand are also conjugated at the 3′ ends to the targeting ligand; or (ii) both the second RNA strand and the first RNA strand are conjugated at the 3′ ends to the targeting ligand and the 5′ end of the second RNA strand is not conjugated. | 2021-05-27 |
20210155927 | METHODS FOR TREATING SICKLE CELL DISEASE - The present disclosure provides a method of modifying a globin gene in the genome of a hematopoietic stem/progenitor cell (HSPC), the method comprising: A) obtaining HSPCs from an individual having a globin gene comprising a sickle cell disease (SCD)-associated single nucleotide polymorphism (SNP) to generate an in vitro population of CD34+ HSPCs and B) contacting the in vitro population with a genome editing composition, as described in further detail below. Also provided is a method of treating sickle cell disease (SCD) in an individual including administering to an individual an in vitro mixed population derived from the method of modifying a globin gene, as well as kits for practicing the same. | 2021-05-27 |
20210155928 | RNA-AIDED IMMUNOTHERAPEUTICS - The present disclosure provides materials and methods for treating cancer, including Epstein-Barr virus-related cancer. | 2021-05-27 |
20210155929 | DIFFERENTIAL KNOCKOUT OF AN ALLELE OF A HETEROZYGOUS ELANE GENE - II - Methods for inactivating in a cell a mutant allele of the elastase, neutrophil expressed gene (ELANE gene) gene having a mutation associated with severe congenital neutropenia (SCN) or cyclic neutropenia (CyN) and which cell is heterozygous at one or more polymorphic sites selected from the group consisting of: rs10424470, rs4807932, rs10414837, rs376107533, rs3761010, rs10413889, rs3761007, rs10409474, rs3761005, rs351107, rs3761001, rs740021, rs781452480, rs371057361, rs570466264, rs1041904080, rs7250194, rs17216649, rs199720952, rs6510983, rs17223066, rs7255385, rs112639467, rs141213775, rs28591229, rs10469327, rs3834645, rs1683564, rs71335276, and rs8107095, the method comprising
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20210155930 | MICRORNA TARGETING AGENT FOR TREATMENT OF HEART DISEASE - The present invention relates to an oligonucleic acid agent directed against the microRNA miR27b-5p for use in a method of treatment or prevention of heart disease. | 2021-05-27 |
20210155931 | TREATMENT OF RAPIDLY EVOLVING BIOLOGICAL ENTITIES - The present disclosure describes methods and compositions for the treatment of rapidly evolving biological entities (e.g., cancer cells, bacteria, virus, etc.) using therapeutic nucleic acids. | 2021-05-27 |
20210155932 | COMPOSITIONS AND METHODS TO TREAT CANCER - The disclosure provides novel personalized therapies, kits, transmittable forms of information and methods for use in treating patients having cancer, wherein the cancer is amenable to therapeutic treatment with an inhibitor, e.g., an inhibitor of any of the targets disclosed herein. Kits, methods of screening for candidate inhibitors, and associated methods of treatment are also provided. | 2021-05-27 |
20210155933 | TLR-9 AGONISTS FOR MODULATION OF TUMOR MICROENVIRONMENT - A TLR-9 agonist for use in the treatment of a tumor disease, in particular of colon cancer, and for the modulation of the tumor microenvironment. | 2021-05-27 |
20210155934 | ANTISENSE ANTIBACTERIAL COMPOUNDS AND METHODS - Provided are antisense morpholino oligomers targeted against bacterial virulence factors such as genes that contribute to antibiotic resistance or biofilm formation, or essential genes, and related compositions and methods of using the oligomers and compositions, for instance, in the treatment of an infected mammalian subject. | 2021-05-27 |
20210155935 | MODULATORS OF EZH2 EXPRESSION - The present embodiments provide methods, compounds, and compositions useful for inhibiting EZH2 expression, which may be useful for treating, preventing, or ameliorating a cancer associated with EZH2. | 2021-05-27 |
20210155936 | MODULATION OF GENE EXPRESSION AND SCREENING FOR DEREGULATED PROTEIN EXPRESSION - Disclosed herein include compositions and methods of modulating protein expression that utilizes an activator or a repressor of a non-sense mediated RNA decay switch exon (NSE). In some embodiments, also included herein are compositions and methods of modulating protein expression that uses an agent that targets a transposed element. | 2021-05-27 |
20210155937 | COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF CD274/PD-L1 GENE - The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the CD274/PD-L1 gene, and methods of using such dsRNA compositions to inhibit expression of CD274/PD-L1. | 2021-05-27 |
20210155938 | TRANS-SPLICING MOLECULES - The present invention features nucleic acid trans-splicing molecules (e.g., pre-mRNA trans-splicing molecules (RTMs)) capable of correcting one or more mutations in the ABCA4 gene or the CEP290 gene. Such molecules are useful in the treatment of disorders associated with mutations in ABCA4, such as Stargardt Disease (e.g., Stargardt Disease 1) and disorders associated with a mutation in CEP290, such as Leber congenital amourosis 10 (LCA 10). Also provided by the invention described herein are methods of using the nucleic acid trans-splicing molecules for correcting mutations in ABCA4 and CEP290 and for treating disorders associated with mutations in ABCA4 and CEP290, such as Stargardt Disease and LCA 10. | 2021-05-27 |
20210155939 | METHODS FOR STABILIZING PRODUCTION OF ACETYL-COENZYME A DERIVED COMPOUNDS - The present disclosure relates to the use of a switch for the production of heterologous non-catabolic compounds in microbial host cells. In one aspect, provided herein are genetically modified microorganisms that produce non-catabolic compounds more stably when serially cultured under aerobic conditions followed by microaerobic conditions, and methods of producing non-catabolic compounds by culturing the genetically modified microbes under such culture conditions. In another aspect, provided herein are genetically modified microorganisms that produce non-catabolic compounds more stably when serially cultured in the presence of maltose followed by the reduction or absence of maltose, and methods of producing non-catabolic compounds by culturing the genetically modified microbes under such culture conditions. | 2021-05-27 |
20210155940 | METHOD FOR MODULATING GENE EXPRESSION BY MODIFYING THE CPG CONTENT - The invention relates to nucleic acid modifications for a directed expression modulation by the targeted insertion or removal of CpG dinucleotides. The invention also relates to modified nucleic acids and expression vectors. | 2021-05-27 |
20210155941 | COMPOSITIONS AND METHODS FOR MAKING ENGINEERED T CELLS - The disclosure provides a vector which can be used in a method of generating engineered T cells for use in an autologous or allogeneic setting for engineered immunotherapy. The knockdown of endogenous TCR expression through a vector comprising a miRNA cassette allows for engineering of cells that efficiently express a therapeutic TCR. | 2021-05-27 |
20210155942 | Bacteria-Based Protein Delivery - The present invention relates to recombinant Gram-negative bacterial strains and the use thereof for delivery of heterologous proteins into eukaryotic cells. | 2021-05-27 |
20210155943 | Bakers's Yeast Expressing Anti-Staling/Freshness Amylases - A recombinant yeast cell comprising a heterologous polynucleotide encoding an anti-staling/freshness amylase; in particular an anti-staling/freshness amylase selected from the group consisting of a maltogenic amylase (EC 3.2.1.133), a beta-amylase (EC 3.2.1.2), and a glucan 1,4-alpha-maltotetrahydrolase (EC 3.2.1.60). | 2021-05-27 |
20210155944 | ACETATE TOXICITY TOLERANCE IN RECOMBINANT MICROBIAL HOST CELLS - Acetate is a potent microbial inhibitor which can affect the performance of yeast in ethanolic fermentation. The present disclosure provides a recombinant microbial host cell having (i) a first genetic modification for increasing the activity of one or more proteins that function in a first metabolic pathway to convert acetate into an alcohol in the microbial host cell; (ii) a second genetic modification for increasing the activity of one or more proteins that function in a second metabolic pathway to import glycerol in the recombinant microbial host cell (iii) a third genetic modification for increasing the activity of one or more proteins that function in a third metabolic pathway to convert a C5 carbohydrate into ethanol in the microbial host cell. The recombinant microbial host cell comprises and natively expresses native proteins that function in a fourth native metabolic pathway to produce glycerol in the microbial host cell. | 2021-05-27 |
20210155945 | ACID-RESISTANT YEAST WITH SUPPRESSED ETHANOL PRODUCTION PATHWAY AND METHOD FOR PRODUCING LACTIC ACID USING SAME - The present invention relates to an acid-resistant yeast endowed with a lactic acid production ability and having a suppressed ethanol production pathway, and a method for producing lactic acid using same. According to the present invention, by effectively suppressing the production of ethanol in an acid-resistant yeast, and by expressing an LDH enzyme with strong expression and high efficiency, it is possible to produce lactic acid with high yield even at low pH without degrading growth. | 2021-05-27 |
20210155946 | RECOMBINANT MICELLE AND METHOD OF IN VIVO ASSEMBLY - A method of in vivo assembly of a recombinant micelle including: introducing a plasmid into a plant cell, wherein: the plasmid includes a segment of deoxyribonucleic acid (DNA) for encoding a ribonucleic acid (RNA) for a protein in a casein micelle, the segment of DNA is transcribed and translated; forming recombinant casein proteins in the plant cell, wherein: the recombinant casein proteins include a κ-casein and at least one of an αS | 2021-05-27 |
20210155947 | PROTEIN EXPRESSION SYSTEMS - The invention is based on an expression enhancer sequence derived from the RNA-2 genome segment of a bipartite RNA virus, in which a target initiation site in the RNA-2 genome segment has been mutated. Deletion of appropriate start codons upstream of the main RNA2 translation initiation can greatly increase in foreign protein accumulation without the need for viral replication. Also provided are methods, vectors and systems, including the ‘hyper-translatable’ Cowpea Mosaic Virus (“CPMV-HT”) based protein expression system. | 2021-05-27 |
20210155948 | METHOD FOR INCREASING THE EXPRESSION LEVEL OF A NUCLEIC ACID MOLECULE OF INTEREST IN A CELL - The present invention method for increasing the expression level of a nucleic acid molecule of interest in a cell, preferably a plant cell by means of promoter activating nucleic acid sequences, which are able to increase expression of a nucleic acid molecule of interest in a cell or an organism upon site-specific introduction into a recipient promoter controlling the expression of the nucleic acid molecule of interest. The invention also provides methods to identify such promoter activating elements and methods to introduce them into an organism or a cell to specifically increase the expression of a nucleic acid molecule of interest. Furthermore, the invention also relates to the use of the promoter activating elements to increase the expression of a nucleic acid molecule of interest. | 2021-05-27 |
20210155949 | IMPROVING AGRONOMIC CHARACTERISTICS IN MAIZE BY MODIFICATION OF ENDOGENOUS MADS BOX TRANSCRIPTION FACTORS - Genome edited plants, plant cells, seeds and plant parts of maize are provided where expression levels and/or activities of MADS-box transcription factors are modulated to improve one or more agronomic characteristics such as grain yield. Also provided are compositions comprising polynucleotides encoding polypeptides and guide RNAs targeted to endogenous maize MADS-box proteins including for example, targeted site-directed mutagenesis using CRISPR-associated nucleases. Additionally, various methods of employing the polynucleotides and genetic modifications in plants, such as methods for modulating expression level in a maize plant and methods for increasing yield of a maize plant are also provided herein. | 2021-05-27 |
20210155950 | GENE OSNIA3 OF RICE NITRATE REDUCTASE NIA3 PROTEIN, AND ITS APPLICATION - The present invention discloses a gene OsNia3 of a rice nitrate reductase NIA3 protein. The cDNA sequence of the gene is as set out in SEQ ID NO.1, and the rice NIA3 protein encoded by it has an amino acid sequence as set out in SEQ ID NO.2. A homozygous mutant in which the rice gene OsNia3 is knocked out and a homozygous line in which the OsNia3 is over-expressed are obtained by utilizing a transgenic technology. It has been discovered by analysis that the line in which the OsNia3 gene is knocked out has a shortened plant height and a shorted growth period; while the line in which the OsNia3 is over-expressed has a relatively high plant height and a prolonged growth period. | 2021-05-27 |
20210155951 | MADS BOX PROTEINS AND IMPROVING AGRONOMIC CHARACTERISTICS IN PLANTS - Provided are compositions comprising polynucleotides encoding polypeptides. Also provided are recombinant DNA constructs, plants, plant cells, seed, grain comprising the polynucleotides, and plants, plant cells, seed, grain comprising a genetic modification at a genomic locus encoding a polypeptide. Additionally, various methods of employing the polynucleotides and genetic modifications in plants, such as methods for modulating expression level in a plant and methods for increasing yield of a plant are also provided herein. | 2021-05-27 |
20210155952 | METHODS AND COMPOSITIONS FOR PLANT PATHOGEN RESISTANCE IN PLANTS - The disclosure relates to a plant that is tolerant or resistant to species of | 2021-05-27 |
20210155953 | PLANTS COMPRISING WHEAT G-TYPE CYTOPLASMIC MALE STERILITY RESTORER GENES AND USES THEREOF - Methods are described for selecting or producing a cereal plant comprising a functional restorer gene for wheat G-type cytoplasmic male sterility and nucleic acids and/or polypeptides for use therein. | 2021-05-27 |
20210155954 | CRISPR LOGIC CIRCUITS FOR SAFER AND CONTROLLABLE GENE THERAPIES - Aspects of the disclosure relate to synthetic regulatory systems composed of a multifunctional Cas nuclease, at least two guide RNAs (gRNAs) configured to target distinct nucleotide sequences, and a multilayered regulatory control element comprising ribozyme-based safety switches providing spatial and temporal control over the synthetic circuit in vivo. | 2021-05-27 |
20210155955 | THERAPEUTIC CONSTRUCTS FOR TREATING CANCER - The present disclosure provides nucleic acid constructs for the treatment of cancer, comprising a cancer-specific promoter and one or more therapeutic genes. | 2021-05-27 |
20210155956 | COMPOSITIONS AND METHODS FOR TREATING DUCHENNE MUSCULAR DYSTROPHY - Described herein are triple-splice mutants of dystrophin or utrophin and methods of use thereof for treating Duchenne Muscular Dystrophy. Also provided are viral vectors which comprise a nucleic acid encoding a triple-splice mutant dystrophin or utrophin under the control of regulatory elements direct expression thereof. Compositions are also provided which contain such viral vectors formulated for delivery to a human patient. | 2021-05-27 |
20210155957 | LENTIVIRAL VECTOR AND METHOD FOR DELIVERING EXOGENOUS RNA BY THE LENTIVIRAL VECTOR - A lentiviral vector and a method for delivering an exogenous RNA by the lentiviral vector are provided. The lentiviral vector is prepared by transfecting plasmids containing a genome sequence of the lentiviral vector into a virus-producing cell, collecting a supernatant and concentration. Specifically, according to the principle of combining an RNA-binding protein with an RNA sequence identified by the RNA-binding protein, the RNA-binding protein is integrated into a skeleton of a lentivirus GagPol long-chain protein, and the RNA sequence identified by the RNA-binding protein is connected to the exogenous target RNA, so that the exogenous target RNA is packaged into lentiviral particles during the assembly of the lentiviral particles. The exogenous target RNA can be mRNA, gRNA or RNA with other functions. The present invention can be used in the fields of gene editing, gene therapy, cell therapy, immunotherapy, regenerative medicine and basic biology. | 2021-05-27 |
20210155958 | BIOLUMINESCENT MARKERS OF NEURAL ACTIVITY - Provided is a polypeptide including an amino acid sequence represented by any of SEQ ID NOs:13-24, or a sequence having at least 90% sequence homology with any one of the foregoing, or a sequence having at least 95% sequence homology with any one of the foregoing. Also provided is a polynucleotide including a fluorescent protein connected to an aequorin by a linker, wherein the amino acid sequence of the fluorescent protein is represented by amino acids 1 through 239 of SEQ ID NO:13, amino acids 1 through 239 of SEQ ID NO:14, amino acids 1 through 237 of SEQ ID NO:15, or amino acids 1 through 237 of SEQ ID NO:16, the amino acid sequence of the linker is represented by amino acids 240 through 256 of SEQ ID NO:13, and the amino acid sequence of the aequorin is represented by amino acids 257 through 448 of SEQ ID NO:13, amino acids 257 through 450 of SEQ ID NO:17, or amino acids 257 through 450 of SEQ ID NO:21. Also provided is a polynucleotide including a sequence that encodes for the polypeptide and a viral vector including the polynucleotide. | 2021-05-27 |
20210155959 | COMPOSITIONS AND METHODS FOR SOMATIC CELL REPROGRAMMING AND MODULATING IMPRINTING - The invention provides methods for improving cloning efficiency and modulating an imprinting control region. In particular embodiments, the invention provides methods for activating a repressed allele within an imprinting control region, thereby treating an imprinting associated disorder. In other embodiments, the invention provides methods for improving somatic cell nuclear transfer efficiency that involve Kdm4d overexpression is a Xist knockout donor cell. | 2021-05-27 |
20210155960 | METHOD FOR PRODUCING BIOETHANOL FROM DATES - The method for producing bioethanol from dates includes manufacturing a suitable substrate for bioethanol from dates and fermenting the date substrate to produce bioethanol. The date substrate may be produced by de-pitting date fruits, heating the flesh with water to produce a mixture, filter pressing the mixture to produce a juice, and concentrated by vacuum drying to produce a date substrate. The date substrate may then be fermented in either a batch or a fed-batch culture. The fermentation may be performed with a thermophilic yeast, such | 2021-05-27 |
20210155961 | BIOCONVERSION OF LEVULINIC ACID IN GENETICALLY ENGINEERED HOSTS - Described is a recombinant expression vector that enables a cell transformed to contain and express the vector to use levulinic acid as a carbon source, thereby converting levulnic acid into 2-butanne. Also described are genetically modified cells transformed to contain and express the vector and methods of using the cells to produce 2-butanone from a medium containing levulinic acid. | 2021-05-27 |
20210155962 | MODIFICATIONS TO LYSINE DECARBOXYLASE ENZYMES - The invention provides CadA polypeptides with mutations that increase activity in alkaline pH compared to the wild-type lysine decarboxylase. The invention also provides methods of generating such mutant polypeptides, microorganisms genetically modified to overexpress the mutant polypeptides, and methods of generating such microorganism. | 2021-05-27 |
20210155963 | COMPOSITIONS AND METHODS FOR MAKING NOSCAPINE AND SYNTHESIS INTERMEDIATES THEREOF - Methods that may be used for the manufacture of the therapeutic chemical compound noscapine and noscapine synthesis intermediates. Compounds useful for the synthesis of noscapine are also provided. | 2021-05-27 |
20210155964 | AMMONIUM BASED IONIC LIQUIDS USEFUL FOR LIGNOCELLULOSIC PROCESSING - Methods and compositions are provided for ionic liquid processing of biomass. | 2021-05-27 |
20210155965 | NUCLEIC ACID AMPLIFICATIONS - A method includes combining a polynucleotide and an amplification reagent mixture to form a reaction mixture, wherein the reaction mixture comprises reversibly bound divalent ions in solution, and adjusting the pH of the reaction mixture to release the reversibly bound divalent ions, thereby initiating amplification of the polynucleotide. | 2021-05-27 |
20210155966 | PRODUCTION OF STEVIOL GLYCOSIDES IN RECOMBINANT HOSTS - The invention relates to recombinant microorganisms and methods for producing steviol glycosides, glycosides of steviol precursors, and steviol glycoside precursors. | 2021-05-27 |
20210155967 | Methods for Producing Polypeptides in Protease-Deficient Mutants of Trichoderma - The present invention relates to mutants of a parent | 2021-05-27 |
20210155968 | NEUROTRANSMITTER TRANSPORT IN PROBIOTICS - The present invention is directed to methods of probiotic selection and use based on the capability of microbial biogenic amine uptake as a method for targeted clinical and veterinary applications, including promoting health and well-being and/or treating therapeutic conditions. The present invention utilizes a microbially-focused approach for the development of drug selection and/or probiotic administration in a variety of diseases and disorders. | 2021-05-27 |
20210155969 | METHODS AND COMPOSITIONS FOR THE DETECTION OF BETA-LACTAMASES - Presented herein are methods and compositions for the detection of specific beta-lactamases, including class A serine carbapenemases, metallo-beta-lactamases, AmpC beta-lactamases, and extended-spectrum beta-lactamases (ESBLs). The methods presented herein include methods that permit the detection of the presence of specific beta-lactamases in bacterial samples within as few as 2 to 10 minutes. | 2021-05-27 |
20210155970 | ?-1,6-GLUCANASE MUTANT, AND METHOD FOR MEASURING ?-1,6-GLUCAN - A β-1,6-glucanase mutant which is a mutant of β-1,6-glucanase (EC 3.2.1.75), wherein a Glu residue located at a position corresponding to Glu (E)-321 in SEQ ID NO: 1 is substituted by an amino acid residue X or a Glu (E) residue located at a position corresponding to each of Glu (E)-225 and Glu (E)-321 in SEQ ID NO: 1 is substituted by an amino acid residue X, wherein the amino acid residue (X) is selected from the group consisting of Gln (Q), Gly (G), Ala (A), Leu (L), Tyr (Y), Met (M), Ser (S), Asn (N), and His (H); and a method for measuring β-1,6-glucan, including measuring β-1,6-glucan bonded to the mutant. | 2021-05-27 |
20210155971 | METHODS OF DETECTING AMINO ACID DEFICIENCIES - The present application relates to a method of screening a subject (and/or treating a subject) for a disease. The application further relates to cells and kits for determination of a disease. Also contemplated are treatments, including those based on a personalized cell model system that determines a subject's threshold for a disease and their personalized treatment. | 2021-05-27 |
20210155972 | TARGETED RARE ALLELE CRISPR ENRICHMENT - Methods of detecting a mutation comprise introducing a Cas endonuclease complex to a nucleic acid sample, wherein guide RNA in the Cas endonuclease complex bind to a location of a suspected mutation. Unbound nucleic acid in the sample is degraded or separated from the bound complex, and presence of the mutation is detected by detecting bound Cas endonuclease complex. The Cas endonuclease complex comprises a Cas endonuclease and guide RNA. The guide RNA is designed to bind to the location of the suspected mutation. In some instances, the Cas endonuclease complex comprises a detectable label, such as a fluorescent label. Therefore, detecting presence of the mutation comprises detecting presence of the label. An exonuclease may be used to degrade or digest unbound nucleic acid and isolate the mutation. Methods include further analysis of the isolated mutation. | 2021-05-27 |
20210155973 | METHODS FOR DNA TARGETS DETECTION DIRECTLY IN CRUDE SAMPLES THROUGH POLYMERASE CHAIN REACTION AND GENOTYPING VIA HIGH RESOLUTION MELTING ANALYSIS - A method id disclosed for DNA targets detection directly in crude samples through Polymerase Chain Reaction (PCR) and genotyping via High Resolution Melting (HRM) analysis. The method comprises diluting the crude sample, treating the diluted crude sample by performing a ramp of increasing and then decreasing temperature, performing PCR amplification and then an HRM analysis. The method further comprises monitoring, during the HRM analysis, the change in the signal emission resulting from the temperature-induced denaturation of the double-stranded amplicons into two single-stranded DNA, due to the release of an intercalating molecule or compound. The detection of DNA targets in the crude sample is performed through a reader analysing the signal variation, obtaining the result of the analysis through a graphic interface connected to the reader. | 2021-05-27 |
20210155974 | NUCLEIC ACID INTEGRATED DETECTION METHOD AND DETECTION REAGENT TUBE - A nucleic acid integrated detection method and detection reagent tube are provided, separating a lysis solution, a cleaning solution and a reaction solution in a detection reagent tube by providing a plurality of separation plugs in an over-under arrangement and disposing a hydrophobic layer in liquid or solid phase on each separation plug; adding a sample into the lysis solution; extracting nucleic acid in the sample using magnetic nanobeads; and then driving the magnetic nanobeads carrying the nucleic acid to sequentially pass through each hydrophobic layer along a magnetic bead channel and into the cleaning solution and the reaction solution to realize a cleaning and amplification for the nucleic acid, and finally, detecting the nucleic acid of the sample by an external device using an optical detection method, thus realizing a plurality of steps of nucleic acid extraction, cleaning and amplification reactions in the same detection reagent tube. | 2021-05-27 |
20210155975 | METHOD AND SYSTEM FOR SAMPLING MATERIAL FROM CELLS - Methods, systems, and devices for sampling/isolating material from cells. An exemplary system may comprise a chip including an electrode array of sampling electrodes arranged along a surface of the chip. A cell-receiving area may be located adjacent the surface of the chip. The system also may comprise a tag array of tags supported by the chip and aligned with the electrode array. Each tag of the tag array may include an identifier that is unique to the tag within the tag array. Each tag may be configured to bind nucleic acids, or a capturing agent distinct from the tag may be aligned with each sampling electrode of the electrode array to capture a protein or other analyte of interest. The system further may comprise a control circuit configured to apply an individually controllable voltage to each sampling electrode of the electrode array and measure an electrical property of the sampling electrode. | 2021-05-27 |
20210155976 | HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES - The present report relates to hybridizing single-stranded (ss-) oligonucleotides which entirely consist of locked nucleic acid (LNA) monomers. The present document shows hybridization experiments with pairs of entirely complementary ss-oligonucleotides which fail to form a duplex within a given time interval. The present report provides methods to identify such incompatible oligonucleotide pairs. In another aspect, the present report provides pairs of complementary ss-oligonucleotides which are capable of rapid duplex formation. The present report also provides methods to identify and select compatible oligonucleotide pairs. In yet another aspect the present report provides use of compatible oligonucleotide pairs as binding partners in binding assays, e.g. immunoassays. | 2021-05-27 |
20210155977 | COUMARIN COMPOUNDS AND THEIR USES AS FLUORESCENT LABELS - The present application relates to new coumarin compounds and their uses as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications. | 2021-05-27 |
20210155978 | ANALYTICAL SYSTEMS AND METHODS FOR NUCLEIC ACID AMPLIFICATION USING SAMPLE ASSIGNING PARAMETERS - Systems and methods for performing a plurality of nucleic acid amplification assays in an automated analyzer. A first nucleic acid amplification assay of the plurality is performed in accordance with a first set of assay parameters which consist of system-defined parameters. And a second nucleic acid amplification assay of the plurality is performed in accordance with a second set of assay parameters which includes one or more user-defined parameters. | 2021-05-27 |
20210155979 | METHOD OF DETECTING TARGET NUCLEIC ACID USING ROLLING CIRCLE AMPLIFICATION AND COMPOSITION FOR DETECTING TARGET NUCLEIC ACID - The present invention relates to a method of detecting a target nucleic acid on the basis of rolling circle amplification (RCA), and more specifically, to a method of detecting a target nucleic acid, the method in which a target nucleic acid (a nucleic acid having a target nucleic acid sequence), when present, forms a circular template with a template for performing an amplification reaction, wherein during the amplification reaction, a restriction enzyme is added to further induce a new RCA reaction, thus increasing the reaction rate and sensitivity, and to an RCA composition for implementing the method. The method of detecting a target nucleic acid according to the present invention, by detecting a barcode sequence predefined according to the type of the target nucleic acid, enables multiple detections of the presence of the target nucleic acid without sequencing, is inexpensive for not using costly enzymes, such as CRISPR, can detect barcode sequences, and can utilize various existing nucleic acid detection systems, and thus, can be useful in the detection of gene mutations. | 2021-05-27 |
20210155980 | MOLECULAR QUALITY ASSURANCE METHODS FOR USE IN SEQUENCING - The present invention relates to quality assurance methods for use in amplification techniques, such as Next Generation Sequencing (NGS). | 2021-05-27 |
20210155981 | SYSTEM AND KIT FOR DETECTING THE NUMBER OF CGG REPEATS IN THE 5' UNTRANSLATED REGION OF FMR1 GENE - Disclosed are a detection system and a detection kit for the number of CGG unit repeats in the 5′ untranslated region of genes. The detection system comprises three primers located upstream, downstream and at the boundary of the repeat of CGG repeats, and the number of CGG repeat units can be determined according to the results of the detected full-length product size and number of CGG product. In particular, since the primer located at the boundary of the repeating fragment has stronger binding ability to the corresponding template, the maximum CGG product can be determined more clearly, thereby the specific number of CGG repeats can be accurately determined, the number of repeats which is less than 60 repeats can be effectively and accurately determined, and it is possible to clearly determine whether there is a genotype with a larger number of repeats. | 2021-05-27 |
20210155982 | PIPELINE FOR SPATIAL ANALYSIS OF ANALYTES - Systems and methods for spatial analysis of analytes include placing a sample on a substrate having fiducial markers and capture spots. Then, an image of the sample is acquired and sequence reads are obtained from the capture spots. Each capture probe plurality in a set of capture probe pluralities is (i) at a different capture spot, (ii) directly or indirectly associates with analytes from the sample and (iii) has a unique spatial barcode. The sequencing reads serve to detect the analytes. Sequencing reads include a spatial barcode of the corresponding capture probe plurality. Spatial barcodes localize reads to corresponding capture spots, thereby dividing them into subsets, each subset for a respective capture spot. Fiducial markers facilitate a composite representation comprising (i) the image aligned to the capture spots and (ii) a representation of each subset of sequence reads at respective positions within the image mapping to the corresponding capture spots. | 2021-05-27 |
20210155983 | CYCLOOCTATETRAENE CONTAINING DYES AND COMPOSITIONS - Embodiments of the present disclosure relate to cyclooctatetraene containing dyes and their uses as fluorescent labels. Also provided are composition containing cyclooctatetraene. The dyes and compositions may be used in various biological applications, such as nucleic acid sequencing. | 2021-05-27 |
20210155984 | HIGHLY SENSITIVE IN VITRO ASSAYS TO DEFINE SUBSTRATE PREFERENCES AND SITES OF NUCLEIC-ACID BINDING, MODIFYING, AND CLEAVING AGENTS - Methods and compositions for performing highly sensitive in vitro assays to define substrate preferences and off-target sites of nucleic-acid binding, modifying, and cleaving agents. | 2021-05-27 |
20210155985 | SURFACE CONCATEMERIZATION OF TEMPLATES - Presented herein are methods and compositions for concatenating template strands during the bridge amplification process. The methods are useful for surface amplification at improved densities. The methods and compositions provided herein enable creation of clusters that are brighter, but at the same densities as currently achieved using standard cluster amplification. | 2021-05-27 |
20210155986 | NON-INVASIVE DETECTION OF RESPONSE TO IMMUNOTHERAPY - Provided herein are method of determining the efficacy of an immunotherapy in a subject by detecting changes in levels of circulating tumor DNA (ctDNA) and/or differences in TCR clonotype levels. Also provided herein are method of determining resistance to an immunotherapy in a subject by detecting changes in levels of circulating tumor DNA (ctDNA) and/or differences in TCR clonotype levels. | 2021-05-27 |
20210155987 | CIRCULATING RNA SIGNATURES SPECIFIC TO PREECLAMPSIA - The present invention includes methods and materials for use in the detection preeclampsia and/or determining an increased risk for preeclampsia in a pregnant female, the method including identifying in a biosample obtained from the pregnant women a plurality of circulating RNA (C-RNA) molecules. | 2021-05-27 |
20210155988 | SYSTEM AND METHOD FOR CLEANING NOISY GENETIC DATA AND DETERMINING CHROMOSOME COPY NUMBER - Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment, the chromosome copy number can be determined from the measured genetic data, with or without genetic information from one or both parents. | 2021-05-27 |
20210155989 | TUMOR ORGANOID CULTURE COMPOSITIONS, SYSTEMS, AND METHODS - Provided herein are novel organoid culture media, organoid culture systems, and methods of culturing tumor organoids using the subject organoid culture media. Also provided herein are tumor organoids developed using such organoid culture systems, methods for assessing the clonal diversity of the tumor organoids, and methods for using such tumor organoids, for example, for tumor modelling and drug development applications. In particular embodiments, the tumor organoid culture media provided herein is substantially free of R-spondins (e.g., R-spondin1). | 2021-05-27 |
20210155990 | NF-KB REGULATED GENE EXPRESSION ASSAY FOR ASSESSING EFFICACY OF MALT1 INHIBITORS - Methods and reagents for determining treatment efficacy of a MALT1 inhibitor in a human subject are described. The method involves determining MALT1 regulated gene expression in stimulated PBMCs of a blood sample obtained from the subject. The method provides information for guiding treatment decisions for those subjects receiving a MALT1 inhibitor therapy, improves the accuracy of optimizing therapy, reduces toxicity, and/or monitors the efficacy of therapeutic treatment. | 2021-05-27 |
20210155991 | A METHOD OF DETERMINING A RISK OF CANCER - There is provided a method of determining a risk of gastrointestinal cancer in a human subject, the method comprising: determining in a biological sample of the subject, whether mutation is present in at least one CTCF-binding sites (CBS) overlapping regions, or portions or flanking sequences thereof, or at least one non-CBS regions, or portions or flanking sequences thereof, wherein presence of mutation in at least one CBS overlapping regions, or portions or flanking sequences thereof, and/or at least one non-CBS regions, or portions or flanking sequences thereof, is indicative of a risk of gastrointestinal cancer in the subject. There are also provided a method of treating gastrointestinal cancer in a human subject and related kits. | 2021-05-27 |
20210155992 | SYSTEMS AND METHODS FOR DETECTING CANCER VIA cfDNA SCREENING - A genomic data processing system can be configured to process next-generation sequencing information. The genomic data processing system described herein can accurately detect mutations in nucleic acid (e.g., cell free DNA (cfDNA) sequence reads associated with plasma nucleic acid samples. The genomic data processing system of the present disclosure also detects microsatellite instability in nucleic acid sequence reads with a higher degree of sensitivity compared to existing genomic data processing systems. | 2021-05-27 |
20210155993 | DETECTION OF LUNG NEOPLASIA BY AMPLIFICATION OF RNA SEQUENCES - Provided herein is technology for lung neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of lung cancer. | 2021-05-27 |
20210155994 | BIOMARKER FOR DETERMINING AGING, DETERMINING OBESITY AND DIAGNOSING CANCER AND DIAGNOSTIC KIT USING THE SAME - The present disclosure relates to a biomarker capable of detecting the genes T3dh (type Ill alcohol dehydrogenase, CG3425), fbp (fructose 1,6-bisphosphatase, CG31692) and AGL (amylo-alpha-1,6-glucosidase, 4-alpha-glucanotransferase, CG9485), which are involved in the induction and occurrence of aging, obesity and cancer, and thereby determining the progression of aging, determining obesity and diagnosing cancer rapidly, accurately and simply. The biomarker may be used to analyze or diagnose the progression of aging, cancer and obesity in a human, a non-human mammal or an insect individually or collectively. | 2021-05-27 |
20210155995 | CONTROLLED PH BIOMASS TREATMENT - A method for treating biomass including lignocellulosic polymers. The biomass is treated in a mixture of water with at least one oxidizing agent and steam at a temperature in a range of from about 130° C. to about 220° C. for a period from about 5 seconds to about 10 hours. The pH of the mixture is periodically measured for substantially an entire duration of the treating step. As necessary, based on the measured pH of the mixture, adjusting the pH of the mixture into a range of from about pH 4.5 to about pH 7.5 by adding a base to the mixture. | 2021-05-27 |
20210155996 | METHOD FOR HEATING A METAL COMPONENT TO A TARGET TEMPERATURE AND CORRESPONDING ROLLER HEARTH FURNACE - The method for heating a metal component to a target temperature, in which the component has a preliminary coating and is passed through a furnace that has at least four zones, which can be respectively adjusted to an individual zone temperature, wherein the component is passed successively through at least an initial heating zone, a plateau zone, a peak heating zone and an end zone and wherein the initial heating zone is adjusted to an initial heating temperature, the plateau zone is adjusted to a plateau temperature, the peak heating zone is adjusted to a peak temperature and the end zone is adjusted to the target temperature, the plateau temperature being chosen such that the temperature of the component in the plateau zone lies in a band around a melting temperature of the preliminary coating which is characterized in that the peak temperature lies by at least 100 K [kelvin] above the target temperature. | 2021-05-27 |
20210155997 | METHOD FOR PRODUCING A STEEL COMPONENT PROVIDED WITH A COATING, AND STEEL COMPONENT - The invention relates to a method for producing a steel component by forming of a flat steel product coated with an anticorrosion coating, and to a steel component produced from a steel substrate coated with anticorrosion coating. The steel component is produced by providing a flat steel product coated with an aluminum-based anticorrosion coating, heat-treating a blank formed from the coated flat steel product, in a furnace, where 0.0034° C./min≤Q≤0.021° C./min, with Q=(T*d)/(t*L), T=furnace temperature in ° C., d=blank thickness in mm, t=dwell time of the blank in the furnace in min, L=furnace length in m, and shaping the blank in a shaping tool. The steel component comprises a steel substrate and, at least on one side of the steel substrate, an anticorrosion coating which comprises at least one first and one second silicon-rich layer (Si1, Si2) and also one first and one second low-silicon layer (A, B), where the quotient X formed from the thickness (dB) of the second low-silicon layer (B) in μm by the thickness (dA) of the first low-silicon layer (A) in μm is at least 0.4 and at most 1.1. | 2021-05-27 |
20210155998 | MARTENSITIC STAINLESS STEEL SHEET, METHOD FOR MANUFACTURING SAME, AND SPRING MEMBER - A martensitic stainless steel sheet has a composition containing, (mass %), from 0.10 to 0.15% of C, from 0.05 to 0.80% of Si, from 0.05 to 2.00% of Mn, 0.040% or less of P, 0.003% or less of S, from 0.05 to 0.50% of Ni, from 11.0 to 15.0% of Cr, from 0.02 to 0.50% of Cu, from 0.005 to 0.06% of N, from 0.001 to 0.20% of Al, from 0 to 1.00% of Mo, from 0 to 0.50% of V, from 0 to 0.01% of B, balance Fe and unavoidable impurities. An M value=420C−11.5Si+7Mn+23Ni−11.5Cr−12Mo−10V+9Cu−52Al+470N+189 is 100 or more. A carbonitride number density having a circle equivalent diameter of 1.0 μm or more is 15.0 or less per 0.01 mm | 2021-05-27 |
20210155999 | ZINC-PLATED STEEL SHEET AND MANUFACTURING METHOD THEREOF - A zinc-plated steel sheet of an aspect of the present invention includes a steel sheet having a predetermined chemical composition and a zinc-plated layer. In the steel sheet, steel microstructures in a range of ⅛ thickness to ⅜ thickness, having the center at ¼ thickness from a steel sheet surface, include, by vol %, ferrite: 0% to 10%, bainite: 0% to 30%, tempered martensite: 50% or more, fresh martensite: 0% to 10%, retained austenite: more than 10% and 30% or less, and pearlite: 0% to 5%. In the zinc-plated steel sheet, the amount of hydrogen emitted when the steel sheet is heated to 200° C. from room temperature after removal of the zinc-plated layer is 0.40 ppm or less per mass of the steel sheet, the tensile strength is 1470 MPa or more, and no cracking occurs in a U-shape bending test where a stress equivalent to 1000 MPa is applied for 24 hours. | 2021-05-27 |
20210156000 | SHEET-METAL FORMED COMPONENT AND METHOD FOR THE PRODUCTION OF THE SHEET-METAL FORMED COMPONENT - The invention relates to a sheet-metal formed component and a method or producing the sheet-metal formed component, produced by hot-working and press-quenching from a quenchable, unitary and materially uniform steel alloy, wherein the sheet-metal formed component has multiple superposed martensite layers, wherein a respectively outer martensite layer of the sheet-metal formed component has higher ductility than an underlying martensite layer. | 2021-05-27 |
20210156001 | WELDING BASE METAL FOR RECYCLING RAILWAY WHEEL AND METHOD FOR RECYCLING RAILWAY WHEEL USING THE SAME - The present disclosure relates to a welding base metal for recycling a railway wheel and a method for recycling a railway wheel using the same, which can overlay-weld a railway wheel with a welding base metal suitable for overlay-welding a railway wheel through a heat treatment, form a surface hardened layer, and strengthen the metal structure of the railway wheel, in order to recycle the railway wheel. | 2021-05-27 |
20210156002 | CONNECTION BETWEEN FORKS AND HANGERS ON FORKS - A method for welding at least one hanger to a fork. A friction welding process may be used to create a weld between the hanger and the fork, after which the heat-affected zone (HAZ) may be allowed to cool. Preferably the cooling occurs until martensite is formed, after which a post-tempering current is applied to the HAZ. | 2021-05-27 |
20210156003 | RECOVERY OF METALS FROM PYRITE - A process is disclosed for the recovery of a metal from a pyrite-bearing material. The process comprises thermally decomposing the pyrite-bearing material so as to produce a material comprising pyrrhotite (FeS). The process also comprises leaching the material comprising pyrrhotite with an acid such that the iron in the pyrrhotite is oxidised to a +3 oxidation state, elemental sulphur is produced and the metal is released from the pyrite-bearing material. | 2021-05-27 |
20210156004 | NICKEL-BASED SUPERALLOY FOR DIFFUSION BONDING AND METHOD FOR DIFFUSION BONDING USING THE SAME - The present invention relates to a nickel-based superalloy for diffusion bonding, which includes a surface depletion layer in a state in which an aluminum (Al) or titanium (Ti) content is depleted, the surface depletion layer being formed to a depth of 50 μm or less from a surface for diffusion bonding, and a method for diffusion bonding using the same. | 2021-05-27 |
20210156005 | PROCESS FOR MANUFACTURING AN ALUMINUM ALLOY PART - The invention relates to a process for manufacturing a part ( | 2021-05-27 |
20210156006 | METHOD FOR PROCESSING HIGHLY ALLOYED ALUMINUM ALLOY SHEET WITH HIGH ROLLING YIELD - The present invention discloses a method for processing a highly alloyed aluminum alloy sheet with a high rolling yield, including the steps of cold rolling and hot rolling of an alloy sheet followed by heat treatment. The highly alloyed Al—Cu—Mg—Ag alloy sheet is subjected to short-time solution treatment and quenching at high temperature for multiple times by increasing the solution treatment temperature and shortening the solution treatment time. In this way, the mechanical properties of the alloy at room temperature and high temperature match with or even exceed those of a conventional alloy subjected to long-time solution treatment at high temperature. The present invention implements multiple times of short-time continuous solution treatment and quenching of a highly-alloyed coiled aluminum alloy sheet. This prevents a large amount of scraps caused by the conventional processes of segmented solution treatment and quenching of the coiled material and stretching straightening treatment. | 2021-05-27 |
20210156007 | ALUMINUM-COBALT-CHROMIUM-IRON-NICKEL-SILICON ALLOY, POWDER AND CLADDING THEREOF - An aluminum-cobalt-chromium-iron-nickel-silicon alloy has atomic percentages of 4-12 at % aluminum, 15-25 at % cobalt, 25-35 at % chromium, 4-8 at % iron, 15-25 at % nickel, 10-25 at % silicon, wherein the atomic percentage of aluminum plus silicon is between 18-32 at %. The disclosure applies the alloy design to develop a low-aluminum Al—Co—Cr—Fe—Ni—Si alloy composition, and has high-temperature hardness, high wear resistance, corrosion resistance and high temperature oxidation resistance. | 2021-05-27 |
20210156008 | NANOSTRUCTURE ASSISTED CASTING OF THERMALLY STABLE, ULTRAFINE GRAINED, NANOCRYSTALLINE METALS - Provided herein are nanocrystalline materials comprising, e.g., a matrix including one or more metals; and nanostructures dispersed in the matrix, wherein the matrix is polycrystalline and includes grains having an average size of about 1μm or less. Also provided herein are manufacturing methods of a nanocrystalline materials. | 2021-05-27 |
20210156009 | YTTRIUM-ADDED RARE EARTH PERMANENT MAGNET MATERIAL AND PREPARATION METHOD THEREFOR - The present invention discloses an yttrium-added rare earth permanent magnet material and a preparation method therefor. The chemical formula of the material is expressed as (Y | 2021-05-27 |
20210156010 | MULTIPHASE, COLD-ROLLED ULTRA-HIGH STRENGTH STEEL - A cold-rolled ultra-high strength, multi-phase structured steel is disclosed with improved stamping and forming performance during manufacturing processes, while possessing one or more of the following properties: excellent castability and rollability, excellent galvanizability and/or coatability, excellent formability, excellent fracture resistance, excellent stretch formability and stretch flangeability, excellent dent resistance, excellent durability, excellent impact performance and structural performance, excellent intrusion and crash resistance, and excellent weldability, without the purposeful addition of boron. | 2021-05-27 |
20210156011 | SOFT MAGNETIC ALLOY RIBBON AND MAGNETIC COMPONENT - A soft magnetic alloy ribbon having high corrosion resistance and good magnetic properties is obtained. The soft magnetic alloy ribbon contains Fe and M. M is at least one selected from the group consisting of Nb, Ta, W, Zr, Hf, Mo, Cr, and Ti, and a part of M is included in oxides. A maximum point of a concentration of at least one of M included in the oxides is present in a region within 20 nm from the surface, when a concentration distribution of an element contained in the soft magnetic alloy ribbon is measured from a surface toward an interior of the soft magnetic alloy ribbon in a thickness direction. | 2021-05-27 |
20210156012 | STEEL STRIP, SHEET OR BLANK FOR PRODUCING A HOT FORMED PART, PART, AND METHOD FOR HOT FORMING A BLANK INTO A PART - A steel strip, sheet or blank for producing hot formed parts containing at least the following composition in weight %:
| 2021-05-27 |
20210156013 | NEW DUPLEX STAINLESS STEEL - The present disclosure relates to a new duplex stainless steel. Furthermore, the present disclosure relates to a product comprising the duplex stainless steel, which method comprises the step of performing a heat treatment on an object comprising the duplex stainless steel at a predetermined temperature and during a predetermined time. | 2021-05-27 |
20210156014 | A STEEL WIRE, A METHOD FOR MANUFACTURING THE SAME, AND METHOD FOR MANUFACTURING A SPRING OR MEDICAL WIRE PRODUCTS - The invention relates to a steel wire suitable for making a spring or medical wire products which remarkably improve the performance of conventional stainless steel wire. The steel comprises (in wt. %): C: 0.02 to 0.15, Si: 0.1 to 0.9, Mn: 0.8 to 1.6, Cr 16 to 20, Ni: 7.5 to 10.5, Mo: ≤3, Al: 0.5 to 2.5, Ti: ≤0.15, N: ≤0.05, optional elements, and impurities, balance Fe, wherein the total amount of Cr and Ni is 25 to 27 wt. %, and wherein the steel has a microstructure including, in volume % (vol. %), martensite: 40 to 90, austenite: 10 to 60, and delta ferrite: ≤5. | 2021-05-27 |
20210156015 | 3D Printable Stainless Steel Alloy with Antibacterial Properties for Orthopedic Implants - An austenitic stainless steel alloy having antibacterial properties, corrosion resistance properties, and good hardness and strength is provided. A method of manufacturing by gas atomization, metal additive manufacturing, and heat treatment is also provided. The stainless steel alloy composition and powder consisting of chromium (Cr), molybdenum (Mo), manganese (Mn), nickel (Ni), copper (Cu), silicon (Si), nitrogen (N), carbon (C) and iron (Fe) is described. The alloy can be processed into spherical powder by gas atomization or other methods suitable for metal additive manufacturing or metal 3D printing. The powder can be processed by metal additive manufacturing into articles. Heat treatment promotes the formation of copper nanoprecipitates leading to excellent antibacterial properties and good mechanical properties. The constituent elements of the alloy provide for good corrosion resistance. | 2021-05-27 |
20210156016 | PRODUCTION METHOD OF ALUMINUM ALLOY FORGING FOR AUTOMOBILE SUSPENSION - Provided is a production method of an aluminum alloy forging for an automobile suspension having a disturbance affectable surface with not excessively notch-sensitive. The production method includes, as heat treatment processes, a solution heat treatment process, a quenching process, and an artificial age hardening process. The quenching process is performed by bringing a lower surface of the aluminum forging to be disposed on a ground side when assembled to the automobile into contact with water before an upper surface of the aluminum forging opposite to the lower surface is brought into contact with the water. | 2021-05-27 |
20210156017 | HOT-DIP Sn-Zn-BASED ALLOY-PLATED STEEL SHEET AND METHOD OF MANUFACTURING THE SAME - A hot-dip Sn—Zn-based alloy-plated steel sheet according to an aspect of the present invention includes: a steel sheet having a predetermined chemical composition; a diffusion alloy layer provided on one surface or both surfaces of the steel sheet; and a Sn—Zn-plated layer provided on the diffusion alloy layer, in which the diffusion alloy layer contains Fe, Sn, Zn, Cr, and Ni, an area ratio of a Sn—Fe—Cr—Zn phase to a Sn—Fe—Ni—Zn phase in the diffusion alloy layer is 0.01 or more and less than 2.5, the diffusion alloy layer has a coverage of 98% or more with respect to the one surface, the Sn—Zn-plated layer contains 1% to 20% of Zn by mass % and a remainder consisting of Sn and impurities, and an adhesion amount of the Sn—Zn-plated layer is 10 to 80 g/m | 2021-05-27 |
20210156018 | METHOD FOR PRODUCING A STEEL STRIP WITH IMPROVED BONDING OF METALLIC HOT-DIP COATINGS - A method for producing a steel strip containing, in addition to iron as the main component and unavoidable impurities, one or more of the following oxygen-affine elements in wt. %: Al: more than 0.02, Cr: more than 0.1, Mn: more than 1.3 or Si: more than 0.1, where the surface of the steel strip is cleaned, oxidation-treated and annealed. The treated and annealed steel strip is subsequently coated with a hot-dip coat. In order to be less cost-intensive and to achieve uniform, reproducible adhesion conditions for the coat, the steel strip is oxidation-treated prior to the annealing at temperatures below 200° C., where on the surface of the steel strip, with the formation of oxides with iron from the steel strip, an oxide layer is formed, which contains iron oxide and is reduction-treated during the course of the annealing under a reducing atmosphere to achieve a surface consisting substantially of metallic iron. | 2021-05-27 |
20210156019 | REACTIVE SPUTTER DEPOSITION OF DIELECTRIC FILMS - Reactive sputter deposition method and system are disclosed, in which a catalyst gas, such as water vapor, is used to increase the overall deposition rate substantially without compromising formation of a dielectric compound layer and its optical transmission. Addition to the sputtering or reactive gas of the catalyst gas can result in an increase of a deposition rate of the dielectric oxide film substantially without increasing an optical absorption of the film. | 2021-05-27 |
20210156020 | METHOD FOR FORMING VAPOR DEPOSITION PATTERN, PRESSING-PLATE-INTEGRATED TYPE PRESSING MEMBER, VAPOR DEPOSITION APPARATUS, AND METHOD FOR PRODUCING ORGANIC SEMICONDUCTOR ELEMENT - In a method for forming a vapor deposition pattern using a vapor deposition mask provided with a plurality of openings corresponding to a pattern that is produced by vapor deposition, and forming a vapor deposition pattern in a vapor deposition target, the method includes a close contact step of disposing the vapor deposition mask on one surface side of the vapor deposition target, disposing a pressing member and a magnetic plate in layer in this order on the other surface side of the vapor deposition target, and bringing the vapor deposition target and the vapor deposition mask into close contact with each other by using magnetism of the magnetic plate, and a vapor deposition pattern forming step of causing a vapor deposition material released from a vapor deposition source to adhere to the vapor deposition target through openings after the close contact step, and forming the vapor deposition pattern in the vapor deposition target. | 2021-05-27 |
20210156021 | HARD CARBON FILM, MANUFACTURING METHOD FOR SAME, AND SLIDING MEMBER - A hard carbon film that forms a sliding surface of a sliding member, wherein the hard carbon film includes terminal atoms that bond to carbon atoms and has a plurality of protruding shaped parts, part of which protrude from the surface thereof, with the periphery of each of the plurality of protruding shaped parts being terminated by a terminal atom. A manufacturing method for the hard carbon film for producing the hard carbon film on a sliding surface of the sliding member using arc vapor deposition having graphite as the vaporization source, wherein a gas containing the terminal atoms that bond to carbon atoms is introduced, and the plurality of protruding shaped parts is grown on the surface of the hard carbon film while terminating the periphery of the plurality of protruding shaped parts by bonding of the terminal atoms to carbon atoms. | 2021-05-27 |
20210156022 | VAPOR DEPOSITION METHOD AND VAPOR DEPOSITION APPARATUS - The present disclosure relates to the field of vapor deposition technologies, and discloses a vapor deposition method. The vapor deposition method includes: applying an exciting acoustic wave to the target, such that particles in a predetermined location of the target break away from the target and adhere to a predetermined region of the substrate when an energy of the particles is higher than an energy required for the particles to break away from the target. By using the vapor deposition method, losses of vapor deposition materials may be avoided, utilization of the vapor deposition materials may be increased, and thus costs may be reduced. | 2021-05-27 |