21st week of 2010 patent applcation highlights part 40 |
Patent application number | Title | Published |
20100129830 | Label Independent Detection Biosensor Composition and Methods Thereof - A biosensor article including a substrate; a tie-layer attached to the substrate surface; and a nanometer scale cross-linked acryloyl copolymer layer attached, for example, by copolymerization, to the tie-layer, as defined herein. Methods for making the biosensor article or cell culture article and methods for performing an assay of a ligand with the target derivatized biosensor article are also disclosed. | 2010-05-27 |
20100129831 | METHODS FOR DIAGNOSING HYPERSENSITIVITY REACTIONS - The invention is directed to the diagnosis of allergic reactions. Particularly, the invention is directed to in vitro assays for diagnosing systemic hypersensitivity reactions, and identifying agents causing these reactions. | 2010-05-27 |
20100129832 | DETECTION METHOD AND DETECTION REAGENT FOR AUTOIMMUNE PANCREATITIS OR FULMINANT TYPE-1 DIABETES - By detecting an antibody which immunologically reacts with amylase α2-A in a sample, AIP or FT1DM is examined or the possibility of developing FT1DM is determined. Detection of this antibody is for instance carried out by an immunological method using an antigen which immunologically reacts with this antibody. The antigen is preferably a partial fragment containing the amino acid sequence of amino acid numbers 299 to 512 of human amylase α2-A. | 2010-05-27 |
20100129833 | Methods to Identify Modulators - Sucralose-binding TAS2R bitter taste receptors have been identified. Novel methods to identify modulators and in particular inhibitors to the bitter taste of sucralose and an inhibitor, are provided. | 2010-05-27 |
20100129834 | AUTOIMMUNE REGULATION OF PROSTATE CANCER BY ANNEXIN A3 - The present invention relates to a method for the diagnosis of prostate carcinoma comprising the determination of annexin A3 (ANXA3) and/or autoantibodies against ANXA3 with a specific reagent. The method allows differentiation between benign, premalignant and malignant conditions. Further, the method has a prognostic relevance. | 2010-05-27 |
20100129835 | Methods for Selecting Improved Strains - The present invention relates to a system for improving a strain of filamentous fungus that is useful in producing an enzyme of interest such as a cellulase. The invention involves generating genetic diversity in a strain of fungal cells, subjecting the population of cells to selection, and isolating the cells that overproduce the enzyme. The selection techniques involve culturing the population of cells in purified cellulose and/or at an elevated temperature that is adverse to production of the enzyme. | 2010-05-27 |
20100129836 | System for detecting bacteria in blood, blood products, and fluids of tissues - The invention provides methods for screening for the presence of a clinically relevant amount of bacteria in donor blood or a blood product from a donor mammal, particularly blood or a blood product that will be transferred from the donor mammal to a recipient mammal. The method comprises contacting a sample of the donor blood or a blood product with a set of binding agents that comprises binding agents that specifically bind to Gram-negative bacterial antigen and/or binding agents that specifically bind to Gram-positive bacterial antigen, and determining binding of the set of binding agents to the sample, wherein binding indicates the presence of a clinically relevant amount of Gram-positive bacteria and/or Gram-negative bacteria in the donor blood or blood product and no binding indicates the absence of a clinically relevant amount of Gram-positive bacteria and/or Gram-negative bacteria in the donor blood or blood product. | 2010-05-27 |
20100129837 | METHODS OF CAPTURING BACTERIAL WHOLE CELLS AND METHODS OF ANALYZING SAMPLES FOR BACTERIA - In certain embodiments, the invention relates to methods of capturing bacterial whole cells that includes the use of two or more antibodies having antigenic specificities for two or more distinct analytes characteristic of the specific bacterium. In certain embodiments, the invention relates to methods of analyzing a sample for a bacterium of interest. In particular, the methods are useful for detecting one or more analytes characteristic of a bacterium of interest, such as components of cell walls that are characteristic of a bacterium, particularly | 2010-05-27 |
20100129838 | METHODS FOR PREDICTION OF INFLAMMATORY BOWEL DISEASE (IBD) USING SEROLOGIC MARKERS - The present invention provides methods, systems, and code for accurately classifying whether a sample from a pediatric individual is associated with inflammatory bowel disease (IBD) or a clinical subtype thereof. In particular, the present invention is useful for classifying a sample from a pediatric individual as an IBD sample using a statistical algorithm and/or empirical data. The present invention is also useful for differentiating between a clinical subtype of IBD such as Crohn's disease (CD) and ulcerative colitis (UC) using a statistical algorithm and/or empirical data. Thus, the present invention provides an accurate diagnostic prediction of IBD or a clinical subtype thereof and prognostic information useful for guiding treatment decisions. | 2010-05-27 |
20100129839 | Method for in vitro diagnosis of pvl-producing staphylococcus aureus - The present invention relates to a method for in vitro diagnosis of | 2010-05-27 |
20100129840 | Method and Apparatus for Reducing Luminescent Test Result Interferences - This application involves detecting luminescence. Various methods and devices are described that reduce interference of ambient light, including UV radiation, on test results. Such methods and devices include using UV blocking material and covering test components prior to use. | 2010-05-27 |
20100129841 | DETECTION OF A BLOOD COAGULATION ACTIVITY MARKER IN A BODY FLUID SAMPLE - The invention relates to a method for detecting in a body fluid sample at least one blood coagulation activity marker that reflects the blood coagulation activity of an individual. By correlating the amount or concentration of the blood coagulation activity marker present e.g. in a urine sample, it is possible to monitor the blood coagulation activity of a patient following surgery without having to obtain a blood sample from said patient. | 2010-05-27 |
20100129842 | ISOBARICALLY LABELED ANALYTES AND FRAGMENT IONS DERIVED THEREFROM - This invention pertains to isobarically labeled analytes and fragment ions thereof. | 2010-05-27 |
20100129843 | CHARACTERIZATION OF N-GLYCANS USING EXOGLYCOSIDASES - The present disclosure provides methods for analyzing structure and/or composition of N-glycans. Such methods often involve digestion of N-glycans with multiple exoglycosidases. In some embodiments, N-glycans are digested with multiple exoglycosidases simultaneously. In some embodiments, N-glycans are digested with multiple exoglycosidases sequentially. In some embodiments, methods in accordance with the present disclosure involve comparison of cleavage products of N-glycans that have been digested with multiple exoglycosidases simultaneously to N-glycans that have been digested with multiple exoglycosidases sequentially. | 2010-05-27 |
20100129844 | AMINOACYLASE 1 ASSAY METHOD FOR THE IN VITRO DIAGNOSIS OF COLORECTAL CANCER - A method for the in vitro diagnosis of colorectal cancer by determining the presence of Aminoacylase 1 tumor marker in a biological sample taken from a patient suspected of having colorectal cancer. Said method can be used for early diagnosis, screening, therapeutic follow-up and prognosis, and also for relapse diagnosis in relation to colorectal cancer. | 2010-05-27 |
20100129845 | Astaxanthine Biosynthesis in Eukaryotes - The invention relates to a DNA vector comprising (a) a DNA sequence coding for the phytoene desaturase protein that is modified in one position by an amino add exchange providing resistance, and (b) a multiple cloning site into which any DNA sequence to be cloned. The invention also relates to the use of said DNA vector for transforming enkaryotic cells, transformation methods, and transgenic plant cells produced in said manner. | 2010-05-27 |
20100129846 | Isoform specificities of blood serum proteins and their use as differentially expressed protein biomarkers for diagnosis of breast cancer - The present invention discloses twenty two 22 protein biomarkers of breast cancer. More specifically, the present invention discloses the identities, specificities, and uses of up to twenty two (22) protein biomarkers in blood serum for distinguishing between patients with earlier and later stages of breast cancer, patients with benign breast diseases or abnormalities, and normal individuals lacking breast abnormalities. More specifically, the present invention relates to specificities of isoforms of up to 22 protein biomarkers in blood serum for distinguishing between patients with earlier and later stages of breast cancer, patients with benign breast diseases or abnormalities, and normal individuals lacking breast abnormalities. | 2010-05-27 |
20100129847 | METHOD FOR THE DETECTION OF AMYLOID-B OLIGOMERS IN BODY FLUIDS - The present invention relates to a method for the detection of marker of the Alzheimer's disease, namely the amyloid-β oligomers in human CSF, using a combination of steps including demasking the epitopes responsible for antibody binding on the Aβ peptide oligomers as well as detecting fluorescently marked antibodies binding to said epitopes, preferably by using the FRET technology. | 2010-05-27 |
20100129848 | Rapid Mixing Device for Subsecond Analysis of Cell Surface Kinetics in Flow Cytometry - The present invention provides improved flow cytometry tubes containing ports to allow rapid addition and mixing of reagents with sample during flow cytometry. The present invention further provides rapid mixing cytometry devices and method for their use in rapid reagent mixing during flow cytometry. | 2010-05-27 |
20100129849 | CELL OBSERVATION APPARATUS, CELL OBSERVATION METHOD, AND PROGRAM - The present invention relates to a cell observation apparatus that facilitates the setting of schedules. An observation schedule that has already been registered is presented to a user by a time schedule display unit of a schedule setting screen, and a new observation schedule is acquired in response to an input of set values of photographic conditions by the user. Then determination is made whether the photographing time of this observation schedule and the photographing time of the already registered observation schedule overlap, and when the photographing times are determined to overlap, the photographic conditions including the photographing time of one or both of the observation schedules are changed and the observation schedule is registered. The invention can be applied, for example, to incubators for culturing cells. | 2010-05-27 |
20100129850 | METHOD FOR ANALYZING THE EFFECT OF A GASEOUS MEDIUM ON A BIOLOGICAL TEST SYSTEM USING AN EXTRACELLULAR METABOLIZATION SYSTEM AND A DEVICE FOR CARRYING OUT THE METHOD - The invention relates to a method for analyzing the effect of a gaseous medium on a biological test system using an extracellular metabolization system. The method consists of the following steps: a biological test sample is cultivated on a permeable carrier, the gaseous medium is guided over the surface of the biological test system in order to form an exposition atmosphere over the biological test system, the extracellular metabolization system is added to a conservation medium and the permeable carrier is brought into contact with a conservation medium that comprises the extracellular metabolization system below the permeable carrier, in such a manner that the extracellular metabolization system only passes through the permeable carrier and that the biological test system is not submerged by the conservation medium containing the extracellular metabolization system. | 2010-05-27 |
20100129851 | METHODS OF DIAGNOSING MUSCLE DAMAGE - A method for assessing muscle damage in a biological sample obtained from a subject is disclosed. The method involves obtaining a biological sample from a subject being assessed for muscle damage, and evaluating the sample for the presence or absence of a myofilament protein modification product. Preferably, the myofilament protein modification product is a chemical adduct of a myofilament protein. The method can also be used to assess the extent and/or type of muscle damage in a subject by studying the profile of myofilament protein modification products detected in the sample taken from the subject. The invention further provides a method for screening for an agent which modulates the level of a myofilament protein modification product present in a biological sample or for a calcium sensitizing agent. The invention is applicable to cardiac muscle and skeletal muscle. | 2010-05-27 |
20100129852 | Integrated Bioanalyzer - The present invention relates to an in vitro assay method and device that provides for detection and measurement of entities in a fluid sample that can be captured and concentrated in a unitized self-contained enclosed filter apparatus that is analyzed in an optical detection instrument for indications of the entity. It provides for analysis of biological material including cells, their enzymes, or other constituents thereof, that can be identified based on an indicator-generating means. The analyses provided for include detection of the presence of the entity, and changes in the entity over time, such as associated with growth and increasing metabolic activity with an expanding population of cells, or decreasing metabolic activity, for example, due to presence of inhibitory or toxic agents. | 2010-05-27 |
20100129853 | DISEASE MARKERS - The present invention relates to biomarkers for autoimmune disease, and in particular to a method for determining a status of an autoimmune disease in a test subject, comprising measuring production of IL-5 and IL-13, as well as to associated uses and kits. | 2010-05-27 |
20100129854 | LIVER CELL TOXICITY ASSAY - The disclosure provides methods for characterizing the toxicity of a candidate molecule to liver cells as defined herein; methods of culturing metabolically active liver cells on a biosensor as defined herein; and biosensor liver culture systems as defined herein. | 2010-05-27 |
20100129855 | BLOOD CELL ANALYZER, BLOOD CELL ANALYZING METHOD, AND COMPUTER PROGRAM PRODUCT - A blood cell analyzer comprising: a detector for detecting predetermined component of leukocytes contained in a specimen; and a controller, including a memory under the control of a processor, the memory storing: correlation information relating to the correlation between leukocyte distribution data and either stab neutrophil or segmented leukocyte classification data; and instructions enabling the processor to carry out operations, comprising: (a) obtaining leukocyte distribution data of a subject based on the detection results of the detector; (b) obtaining the stab neutrophil or segmented leukocyte classification data based on the correlation information and the leukocyte distribution data of the subject; and (c) outputting the obtained stab neutrophil or segmented leukocyte classification data. A blood cell analyzing method and a computer program product is also disclosed. | 2010-05-27 |
20100129856 | Methods and Devices for Cell Signaling Under Pulse Stimulation - The disclosure provides a device for measuring cellular responses under controlled environments. The disclosure also provides an array of devices for measuring cellular responses under controlled environments. The disclosure also provides methods to study cell signaling using the devices. By using microfluidics, the disclosure enables study of cell signaling under well-defined environment conditions. Such capability can be used for differentiating long-acting ligands from short-acting ligands, for determining the kinetics of receptor resensitization and functional recovery of receptor signaling, and for differentiating the sensitivity of a cell type to laminar flow-induced stress force. Through combination with conventional static label-free cell assays, the full spectrum of a drug compound can be studied in details, thus creating a complete representation of its pharmacology acting on living cells. | 2010-05-27 |
20100129857 | Methods for the isolation and identification of microorganisms - The present invention is directed to a method for separating, characterizing and/or identifying microorganisms in a test sample. The method of the invention comprises an optional lysis step for lysing non-microorganism cells that may be present in a test sample, followed by a subsequent separation step. The method may be useful for the separation, characterization and/or identification of microorganisms from complex samples such as blood-containing culture media. The invention further provides methods for separating, characterizing and/or identifying microorganisms in situ within a single system. | 2010-05-27 |
20100129858 | Method for separation, characterization and/or identification of microorganisms using spectroscopy - The present invention is directed to a method for separating, characterizing and/or identifying microorganisms in a test sample. The method of the invention comprises an optional lysis step for lysing non-microorganism cells that may be present in a test sample, followed by a subsequent separation step. The method may be useful for the separation, characterization and/or identification of microorganisms from complex samples such as blood-containing culture media. The invention further provides for spectroscopic interrogation of the separated microorganism sample to produce measurements of the microorganism and characterizing and/or identifying the microorganism in the sample using said spectroscopic measurements. | 2010-05-27 |
20100129859 | APPARATUS AND METHODS FOR AUTOMATED HANDLING AND EMBEDDING OF TISSUE SAMPLES - An automated machine for handling and embedding tissue samples contained on microtome sectionable supports. The machine includes an input member configured to hold a plurality of the microtome sectionable supports prior to a tissue embedding operation. An output member is configured to hold a plurality of the microtome sectionable supports after the tissue embedding operation. A cooling unit is configured to hold at least one of the microtome sectionable supports during the tissue embedding operation. A motorized carrier assembly is mounted for movement and configured to hold at least one of the microtome sectionable supports. The carrier assembly moves the support from the input member to the cooling unit and, finally, to the output member. A dispensing device dispenses an embedding material onto the microtome sectionable support and at least one tissue sample carried by the microtome sectionable support during the embedding operation. | 2010-05-27 |
20100129860 | Methods of producing the cellulolytic enhancing activity of a polypeptide - The present invention relates to methods of increasing the activity of a polypeptide having cellulolytic enhancing activity, comprising: adding a soluble activating divalent metal cation to a composition comprising the polypeptide having cellulolytic enhancing activity, wherein the presence of the soluble activating divalent metal cation and the polypeptide having cellulolytic enhancing activity increases degradation or conversion of a cellulose-containing material by a cellulolytic enzyme composition compared to the polypeptide having cellulolytic enhancing activity without the soluble activating divalent metal cation. The present invention also relates to compositions, methods for degrading or converting a cellulose-containing material, and methods for producing a fermentation product. | 2010-05-27 |
20100129861 | Isolation and Use of Novel Mammalian DExH Box Helicases - The present invention relates to the isolation, purification, and use of novel mammalian DExH box helicases. In particular, the present invention relates to the isolation, purification and use of DHX29, a novel mammalian RNA helicase. | 2010-05-27 |
20100129862 | Novel lipolytic Enzyme lip1 - The present invention provides a novel nucleic acid sequence, designated LIP1, encoding a lipolytic enzyme and the corresponding encoded amino acid sequences. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding at least one novel lipolytic enzyme, recombinant lipolytic enzyme proteins and methods for producing the same. | 2010-05-27 |
20100129863 | Optimized core promoters and uses thereof - The present invention provides core promoter motif ten elements (MTE) and core promoter constructs comprising the MTEs and an initiator element (Inr) in combination with one or both of a TATA box and a downstream promoter element (DPE) which increases gene expression over the strongest known core promoters. Particularly, an optimized or super core promoter is provided which comprises Inr, MTE, TATA box and DPE elements. The present invention also provides expression vectors and host cells comprising the core promoter constructs. Additionally, methods of increasing production of a protein using the core promoter constructs are provided. | 2010-05-27 |
20100129864 | Novel Bacteriocins, Transport and Vector System and Method of Use Thereof - New bacteriocins capable of inhibiting the growth of bacteria are disclosed, along with methods of obtaining secretion of proteins from lactic acid bacteria, and methods for protecting foodstuffs. | 2010-05-27 |
20100129865 | KETOSE 3-EPIMERASE, ITS PREPARATION AND USES - An object of the present invention is to provide a novel ketose 3-epimerase, a process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, and a process for producing a ketose by using the enzyme. The present invention solves the above objects by providing a ketose 3-epimerase which is obtainable from a microorganism of the genus | 2010-05-27 |
20100129866 | METHOD FOR PRODUCTION OF DIPEPTIDE - According to the present invention, a protein having dipeptide-synthesizing activity, a DNA encoding the protein, a recombinant DNA containing the DNA, a transformant obtained via transformation with the recombinant DNA, a process for producing a protein having dipeptide-synthesizing activity using the transformant or the like, a process for producing a dipeptide using a protein having dipeptide-synthesizing activity, and a process for producing a dipeptide using a culture or the like of a transformant or a microorganism that produces a protein having dipeptide-synthesizing activity as an enzyme source are provided. | 2010-05-27 |
20100129867 | METHOD FOR PRODUCING DIPEPTIDE - The invention provides a microorganism having an ability to produce a protein having a dipeptide synthesizing activity and
| 2010-05-27 |
20100129868 | DELTA 4,5 GLYCURONIDASE COMPOSITIONS AND METHODS RELATED THERETO - The invention relates to Δ4,5 glycuronidase, related compositions, and methods of use thereof. | 2010-05-27 |
20100129869 | Methods and compositions for inactivating glutamine synthetase gene expression - Disclosed herein are methods and compositions for inactivating a glutamine synthetase (GS) gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins. | 2010-05-27 |
20100129870 | METHOD FOR OBTAINING OLIGONUCLEOTIDE - The present invention is to provide a method for obtaining an oligonucleotide such as RNA aptamer having high binding capacity to a target substance with easy-to-use and high purity. The method for obtaining oligonucleotide according to the present invention is as follows: | 2010-05-27 |
20100129871 | PYROPHOSPHOROLYSIS ACTIVATED POLYMERIZATION (PAP) - A novel method of pyrophosphorolysis activated polymerization (PAP) has been developed. In PAP, pyrophosphorolysis and polymerization by DNA polymerase are coupled serially for each amplification by using an activatable oligonucleotide P* that has a non-extendible 3′-deoxynucleotide at its 3′ terminus. PAP can be applied for exponential amplification or for linear amplification. PAP can be applied to amplification of a rare allele in admixture with one or more wild-type alleles by using an activatable oligonucleotide P* that is an exact match at its 3′ end for the rare allele but has a mismatch at or near its 3′ terminus for the wild-type allele. PAP is inhibited by a mismatch in the 3′ specific sequence as far as 16 nucleotides away from the 3′ terminus. PAP can greatly increase the specificity of detection of an extremely rare mutant allele in the presence of the wild-type allele. Specificity results from both pyrophosphorolysis and polymerization since significant nonspecific amplification requires the combination of mismatch pyrophosphorolysis and misincorporation by the DNA polymerase, an extremely rare event. Using genetically engineered DNA polymerases greatly improves the efficiency of PAP. | 2010-05-27 |
20100129872 | SYSTEM AND METHOD FOR MOVEMENT AND POSITIONING OF REACTION MIXTURE DURING NUCLEIC ACID AMPLIFICATION - A system for accurately positioning a reaction mixture during amplification of a nucleic acid includes a reaction vessel that contains the reaction mixture, a first heat exchanger, a second heat exchanger and a pump assembly. The reaction vessel can include .a first zone and a second zone. The first heat exchanger is positioned near the first zone, and the second heat exchanger positioned near the second zone. The first heat exchanger adjusts the temperature of the reaction mixture so the reaction mixture is at a first temperature when the reaction mixture is in the first zone. The second heat exchanger adjusts the temperature of the reaction mixture so the reaction mixture is at a second temperature. The pump assembly adjusts the pressure within the reaction vessel to selectively position the reaction mixture relative to the first zone and the second zone during amplification. The system can include a sensor that monitors the position of the reaction mixture within the reaction vessel. The system can also include a second pump that cooperates with the pump assembly to adjust the position of the reaction mixture within the reaction vessel. | 2010-05-27 |
20100129873 | Highly Parallel Gel-Free Cloning Method - A highly parallel method for gene cloning is presented. PCR products can be isolated using a solid phase and ligated into a positive selection vector. The cloning method has a very high success rate and can be performed entirely by a liquid handling robot with very little human intervention. | 2010-05-27 |
20100129874 | METHOD FOR MULTIPLEXED NUCLEIC ACID PATCH POLYMERASE CHAIN REACTION - The invention encompasses a method for amplifying at least two different nucleic acid sequences. In particular, the method encompasses a multiplexed nucleic acid patch polymerase chain reaction. | 2010-05-27 |
20100129875 | EMULSION PCR AND AMPLICON CAPTURE - Compositions and methods of use are disclosed for clonally amplifying target polynucleotide sequences in solution and attaching the amplicons to a surface by activation of a masked binding moiety. | 2010-05-27 |
20100129876 | Pasting Edge Heater - An apparatus and method for thermal cycling including a pasting edge heater. The pasting edge heater can provide substantial temperature uniformity throughout the retaining elements during thermal cycling by a thermoelectric module. | 2010-05-27 |
20100129877 | Modification of RNA, Producing an Increased Transcript Stability and Translation Efficiency - It was the object of the present invention to provide RNA with increased stability and translation efficiency and means for obtaining such RNA. It should be possible to obtain increased grades of expression by using said RNA in gene therapy approaches. | 2010-05-27 |
20100129878 | METHODS FOR NUCLEIC ACID AMPLIFICATION - The present invention provides methods for amplifying nucleic acid after isolating nucleic acid from a sample using functionalized support material. | 2010-05-27 |
20100129879 | GENOME PARTITIONING USING A NICKING ENDONUCLEASE - A method for partitioning a genome is provided. In certain embodiments, the method comprises: a) nicking a region of the genome using a sequence-specific nicking endonuclease to produce a nicked double-stranded genomic region; b) hybridizing the nicked double-stranded genomic region with an oligonucleotide comprising: i. an affinity tag; and ii. a nucleotide sequence that is complementary to the nucleotide sequence that is immediately adjacent to the nick site, to produce a duplex in which a terminal nucleotide of the oligonucleotide lies immediately adjacent to said a nucleotide of the nick site; c) ligating the terminal nucleotide of the oligonucleotide to the nucleotide of the nick site to produce a ligation product; and d) separating the ligation product from unligated products using the affinity tag. Compositions and kits for practicing the method are provided. | 2010-05-27 |
20100129880 | HOSTS AND FERMENTATION PROCESSES FOR CELLULASE PRODUCTION - A fermentation process for the production of cellulase mixtures is provided. The process comprises providing a genetically modified host filamentous fungus that overexpresses a Xyr1 transcription factor and/or that is partially or completely deficient in expressing one or more hemicellulase enzyme. The host filamentous fungus is cultured in a medium comprising a carbon source. The carbon source contains from about 60 wt % to about 100 wt % hemicellulose-derived carbohydrate and less than 5% of a cellulase-inducing carbohydrate or contains from about 25 wt % to about 100% wt % hemicellulose-derived sugar alcohol in combination with from about 0 wt % to about 75 wt % glucose, glycerol or a combination thereof. | 2010-05-27 |
20100129881 | Antigenic Polysaccharides and Process For Their Preparation - A robust and industrial scale process to afford highly pure antigenic polysaccharides is claimed. | 2010-05-27 |
20100129882 | HYDROLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM - Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. Further provided are polypeptides, e.g., enzymes, having a hydrolase activity, e.g., lipases, saturases, palmitases and/or stearatases and methods for preparing low saturate or low trans fat oils, such as low saturate or low trans fat animal or vegetable oils, e.g., soy or canola oils. | 2010-05-27 |
20100129883 | Substrate-selective co-fermentation process - Biological method for conversion of a lignocellulosic hydrolysate into a desired biochemical product. Use of a plurality of substrate-selective cells allows different sugars in a complex mixture to be consumed concurrently and independently. The method can be readily extended to remove inhibitory compounds from hydrolysate. | 2010-05-27 |
20100129884 | Process for Producing Fermentation Product from Carbon Sources Containing Glycerol using Corynebacteria - The present invention relates to a method for producing fermentation product from various carbon sources containing glycerol using Corynebacteria. More particularly, the present invention relates to a method for producing fermentation product from carbon sources containing glycerol or a part of glycerol with high yield and high productivity, by fermenting Corynebacteria introduced with the foreign gene glpDFK facilitating the use of glycerol and accumulating industrially useful amino acids in the culture medium. | 2010-05-27 |
20100129885 | Methods for the production of n-butanol - Embodiments of the present invention include methods for the production of four carbon alcohols, specifically n-butanol, by a consolidated bioprocessing approach for the conversion of cellulosic material to the desired end product. According to some embodiments, recombinant microbial host cells are provided, preferably | 2010-05-27 |
20100129886 | PRODUCTION OF ISOBUTANOL IN YEAST MITOCHONDRIA - Yeast cells with modified expression of certain enzyme activities in the mitochondria are described for isobutanol production. Modifications described provide an isobutanol biosynthesis pathway in the yeast mitochondria. | 2010-05-27 |
20100129887 | INCREASED PRODUCTION OF ISOBUTANOL IN YEAST WITH REDUCED MITOCHONDRIAL AMINO ACID BIOSYNTHESIS - Yeast cells with reduced activity of certain enzymes involved in branched chain amino acid biosynthesis in yeast mitochondria are described. Target enzymes include threonine deaminase, isopropylmalate synthase, and optionally branched chain amino acid transaminase. | 2010-05-27 |
20100129888 | LIQUEFACTION OF STARCH-BASED BIOMASS - The present invention provides processes for the treatment of a starch-based feedstock. The processes include mixing together a starch-based feedstock and a working fluid to form a slurry, hydrating the starch-based feedstock with the working fluid, adding an enzyme to the slurry, pumping the slurry into a substantially constant diameter passage of a fluid mover, and injecting a high velocity transport fluid into the slurry through one or more nozzles communicating with the passage, thereby further hydrating the starch-based feedstock and activating the starch content of the slurry. Apparatuses for carrying out such processes are also provided. Processes for converting a feedstock to a polysaccharide and systems for producing ethanol using the processes and apparatuses of the invention are also provided. | 2010-05-27 |
20100129889 | AFFINITY SEPARATION METHODS AND SYSTEMS - An affinity matrix comprising a base matrix containing biotin; and a fusion protein attached to the base matrix, wherein the fusion protein contains a matrix binding element capable of binding to the base matrix via biotin and a target binding element capable of binding, or being bound by, at least one target component. | 2010-05-27 |
20100129890 | Cytochrome P450 enzyme complexes and methods of treatment using the same - The present invention provides methods and compositions for balancing electron reduction potentials of formulations in a manner that reduces susceptibility to changes from xenobiotics. The present invention also provides novel compositions of matter based on structuring from a mobile nucleotide integral to its architecture. | 2010-05-27 |
20100129891 | BILIRUBIN OXIDASE MUTANT HAVING THERMAL STABILITY - A heat-resistant bilirubin oxidase mutant is disclosed. The bilirubin oxidase mutant is obtained by deletion, replacement, addition or insertion of at least one amino acid residue of a wild type amino sequence of SEQ. ID. No. 1 of a bilirubin oxidase derived from an imperfect filamentous fungus, | 2010-05-27 |
20100129892 | PROCESS FOR THE PREPARATION OF 1,3-PROPANEDIOL BY A RECOMBINANT MICRO-ORGANISM IN THE ABSENCE OF COENZYME B12 OR ONE OF ITS PRECURSORS - The invention concerns a method for preparing 1,3-propanediol from a carbon-containing substance, said method comprising a step which consists in culturing a recombinant micro-organism not producing coenzyme B12 in the absence of coenzyme B12 or one of its precursors. The invention also concerns a nucleic acid coding for a glycerol dehydratase whereof the catalytic activity is independent of the presence of coenzyme B12 or one of its precursors and a nucleic acid coding for a 1,3-propanol dehydrogenase intervening in the synthesis of 1,3-propanediol. The invention further concerns recombinant vectors and host cells comprising said nucleic acids and the polypeptides coded by the latter. | 2010-05-27 |
20100129893 | OPTIMAL PLACEMENT OF A ROBUST SOLVENT/DETERGENT PROCESS POST VIRAL ULTRAFILTRATION OF AN IMMUNE GAMMA GLOBULIN - The solvent-detergent (S/D) process is used to inactivate enveloped viruses in plasma products. While concentrations of 1.0% detergent and 0.3% tri-n-butyl phosphate solvent have been considered necessary for robust removal of viral activity, we show the effectiveness of solvent-detergent treatment after fractionation and nanofiltration of an immune gamma globulin preparation, which required significantly reduced concentrations of solvent and detergent. Reduced levels of solvent and detergent lead to greater efficiencies in their removal post-inactivation with the potential for greater yields and decreased processing costs. | 2010-05-27 |
20100129894 | Method For Regenerating A Biosensor - In a method for regenerating a biosensor, a biosensor is prepared having a substrate surface on which at least one receptor is immobilized. At least one ligand that is binding specific to the receptor is bound to the receptor, said ligand, together with the receptor, forming a ligand-receptor complex. To regenerate the biosensor, the ligand-receptor complex is brought into contact with an enzyme. The enzyme is selected so that it catalyzes the ligand into fragments. The enzyme is inert with respect to the receptor. | 2010-05-27 |
20100129895 | Biofiltration system for odor control - The invention involves the creation of a corrosion resistant gas treatment system comprising a unitary housing subdivided into at least two internal sections, the only connection between the first and the following section(s) is a gas only passage channel; the design allows the simultaneous remediation of contaminants from multiply contaminated gas streams in which some of the contaminants require the presence of microorganisms tolerant of widely differing pH and moisture needs for their reduction. The operation is simple and very efficient because the absence of fluid communication between the two sections allows keeping the moisture levels, pHs and microorganism profiles of the two sections specifically optimized for the target pollutants in the gas stream. | 2010-05-27 |
20100129896 | SYSTEM FOR DIFFERENTIATING THE LENGTHS OF NUCLEIC ACIDS OF INTEREST IN A SAMPLE - Systems for differentiating the lengths of nucleic acids of interest in a sample are provided. The system includes a microfluidic device, a detector, and a software system. The microfluidic device includes an amplification microchannel or microchamber containing a reaction mixture under conditions that provide one or more amplicons of the nucleic acid of interest. The detector is integral with or proximal to the microfluidic device and is configured to detect the amplicons as one or more signals from a homogenous mixture. The software system interprets one or more coincidentally detected signals to indicate lengths of one or more individual nucleic acid molecules of interest, thereby differentiating the lengths of the nucleic acids of interest. | 2010-05-27 |
20100129897 | BIOLOGICAL COMPONENT-MEASURING UNIT, BIOLOGICAL COMPONENT-MEASURING UNIT PACKAGE, MEDICAL SUPPORT INSTRUMENT KIT, AND MEDICAL SUPPORT INSTRUMENT KIT PACKAGE - A biological component-measuring unit, a package of a biological component-measuring unit, a medical support instrument kit, and a package of a medical support instrument kit, for improving workability and enabling the measurement of components of body fluids hygienically. The biological component-measuring unit comprising a substrate detachably mountable on a medical support device proper, fluid channels fixed to said substrate, the medical support device proper including a fluid transfer structure where fluids in the fluid channels flow in one direction, wherein the fluid channels comprise a biological component-measuring channel which is: attachable to and detachable from a body fluid-drawing channel for drawing a fluid that has been sampled through a body fluid sampler; capable of transferring the fluid in the biological component-measuring channel in one direction, in cooperation with the fluid transfer structure; provided with a biological component sensor for measuring a biological component in the fluid being transferred; and capable of discharging the fluid as a waste after measurement of the biological component. | 2010-05-27 |
20100129898 | REAGENT DELIVERY SYSTEM - A delivery apparatus for selectively delivering one or more liquid reagents into a reaction or test chamber ( | 2010-05-27 |
20100129899 | Flexible Bioreactor - A flexible bioreactor intended for culturing cells in a liquid medium, the bioreactor comprising a flexible wall forming a fluid impermeable bottom wall of the bioreactor when in use, wherein flexible parts of said flexible bottom wall are interrupted by at least one rigid element of said flexible bottom wall, the rigid element and the flexible parts being connected fluid tightly, and wherein the rigid element comprises measuring means allowing for non-invasive monitoring of cellular activity in said bioreactor when in use. | 2010-05-27 |
20100129900 | Layered Flask Cell Culture System - A multilayered cell culture apparatus for the culturing of cells is disclosed. The cell culture apparatus is defined as an integral structure having a plurality of flexible cell culture compartments in combination with a spacer material maintaining air space(s). The expandable compartments of the cell culture apparatus have imparted therein gas permeable membranes in combination with air spaces that will allow the free flow of gases between the cell culture compartments and the external environment. Furthermore an interconnecting passageway is provided between each compartment and between the cell culturing vessel and the external environment. The expandable vessel promotes the growth of large numbers of adherent or suspension cells by providing the volumes of nutrient medium and gaseous exchange. | 2010-05-27 |
20100129901 | HEPATITIS C VIRUS VACCINE - The present invention features Ad6 vectors and a nucleic acid encoding a Met-NS3-NS4A-NS4B-NS5A-NS5B polypeptide containing an inactive NS5B RNA-dependent RNA polymerase region. The nucleic acid is particularly useful as a component of an adenovector or DNA plasmid vaccine providing a broad range of antigens for generating an HCV specific cell mediated immune (CMI) response against HCV. | 2010-05-27 |
20100129902 | Replication Stable and RNase Resistant Chimeras of Pestivirus with Insertion in 3' Nontranslated Region (3'NTR) - The invention relates to the field of nucleic acid amplification, particularly to quality control materials for use in viral RNA assays. It specifically relates to the construction of a recombinant Pestivirus by the identification of a region in the 3′NTR of the viral RNA genome where additional sequence elements can be stably inserted. Chimeric Pestivirus with sequence insertions in the 3′ nontranslated region (3′NTR) of the viral RNA genome were stable in replication and capable of forming infectious, RNase resistant virus particles. This chimeric Pestivirus with a 3′NTR insertion can be utilized as a quality control material in analytical assays for RNA targets, including external, internal controls, quantitative standards in PCR and NAT nucleic acid assays. | 2010-05-27 |
20100129903 | PITX3 EXPRESSION PROMOTERS - Isolated polynucleotides comprising a PITX3 promoter are provided, where a PITX3 regulatory element is operably joined to a PITX3 basal promoter utilizing a non-native spacing between the promoter and regulatory elements. The promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, etc. | 2010-05-27 |
20100129904 | RECOMBINANT HUMAN INTERFERON-LIKE PROTEINS - This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology is described having enhanced anti-viral and anti-proliferative activities in comparison to naturally occurring human interferon alpha 2b (HuIFN-α2b). The invention encompasses a polynucleotide encoding the protein and recombinant vectors and host cells comprising the polynucleotide. Preferably the polynucleotide is selected from the group of polynucleotides each having a sequence at least 93% identical to SEQ ID: No. 1 and the protein is selected from the group of proteins each having an amino acid sequence at least 85% identical to SEQ ID No: 2. The proteins and compositions comprising the proteins can be used for treatment of conditions responsive to interferon therapy, such as viral diseases and cancer. | 2010-05-27 |
20100129905 | MAMMALIAN CYTOKINES; RELATED REAGENTS AND METHODS - Purified genes encoding cytokines from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided. | 2010-05-27 |
20100129906 | Method for Obtaining Xeno-Free Hbs Cell line - A method for obtaining a stable xeno-free hBS cell line, xeno-free hBS cell lines obtained according to said method and use thereof. The method comprises the steps of:
| 2010-05-27 |
20100129907 | HUMAN FORESKIN FIBROBLAST CONDITIONED MEDIA FOR CULTURING ES CELLS - A cell culture comprising human foreskin cells, the human foreskin cells being capable of maintaining stem cells in an undifferentiated state when co-cultured therewith. | 2010-05-27 |
20100129908 | SPACED PROJECTION SUBSTRATES AND DEVICES FOR CELL CULTURE - An article for culturing cells includes a substrate on which cells can be cultured. The substrate has a base surface. An array of projections extends from the base surface. The projections have a height of about 1 micrometer to about 100 micrometers, and have a gap distance along the major surface from center to center between neighboring projections of about 10 micrometers to 80 micrometers. A plurality of arrays of projections may extend from the surface with gaps in the base surface between the arrays. Hepatocytes cultures on such microprojection array substrates maintained in vivo like morphology and membrane polarity. Hepatocytes co-cultured with helper cells on such substrates tended to grow in the area of the arrays, while the helper cells tended to grow in the areas between the arrays. | 2010-05-27 |
20100129909 | DEVICE AND METHOD FOR TREATING BIOMASS - A method for pretreating and disrupting cell structure of biomass by subjecting the biomass to high pressure, thereby disrupting the cell structure of the biomass is provided. Also provided is a device for performing the method, wherein the device includes a cavitating device and a cell structure disrupting device disposed within the cavitating device for disrupting the cell structure and exposing the internal cell structure to enzymes. | 2010-05-27 |
20100129910 | Cell matrix related compositions and their use for generating embryoid bodies - The present invention relates to compositions and methods for the generation of embryoid bodies from embryonic stem cells, and for aggregation of ES cells for establishing ES cell colonies from small numbers of cells. Compositions of the invention, in certain embodiments, comprise embryonic stem cells, an extracellular matrix molecule, and a molecule capable of cross linking. The present invention also relates to methods for embryoid body formation using a composition of the invention and to cells and tissues isolated or derived from an embryoid body generated with a composition or method of the invention. | 2010-05-27 |
20100129911 | Nanoparticulate Affinity Capture for Label Independent Detection System - A biosensor article including a substrate having nanoparticles on the substrate surface, the nanoparticle including:
| 2010-05-27 |
20100129912 | 3D Cell-Culture Article and Methods Thereof - An optically clear, porous polymer composition, an article incorporating the composition, and methods for making and using the composition for cell culture including, for example, regulating or promoting cell function or gene expression as defined herein. | 2010-05-27 |
20100129913 | POLIOMA VECTOR EXPRESSING LONG DOUBLE-STRANDED RNAS - Polyoma viral vector production cell line comprising a heterologous polynucleotide sequence that is capable of being transcribed into an RNA sequence that is capable of folding into double stranded RNA of at least 50 base pairs in length, methods of producing said cell line, uses thereof and recombinant polyoma viral vectors and nucleic acid sequences relating thereto. | 2010-05-27 |
20100129914 | Tol1 FACTOR TRANSPOSASE AND DNA INTRODUCTION SYSTEM USING THE SAME - An object is to provide a Tol1 element transposase and a use thereof. Provided is a Tol1 element transposase containing (a) a protein having the amino acid sequence of SEQ ID No: 1 or (b) a protein having an amino acid sequence homologous to the amino acid sequence of SEQ ID NO: 1 and having an enzymatic activity for transferring Tol1 element. Further, provided are a polynucleotide encoding the transposase and an expression construct containing the polynucleotide therein. The present invention also provides a DNA introduction system including (a) a donor factor having such a structure that a desired DNA is inserted in a transposase gene-defected Tol1 element and (b) a helper factor containing the transposase or the polynucleotide. | 2010-05-27 |
20100129915 | METHODS FOR INDUCING CARDIOMYOGENESIS - The present invention provides methods of inducing cardiomyogenesis and expansion of cardiac progenitors in a population of stem cells or progenitor cells, the methods generally involving inducing a canonical Wnt signaling pathway in the stem cells or progenitor cells. The present invention provides methods of generating a population of cardiomyocytes or cardiac progenitors from a population of stem cells or progenitor cells, the methods generally involving contacting the stem cells or progenitor cells with an agent that induces canonical Wnt signaling. A subject method is useful for generating a population of cardiomyocytes or cardiac progenitors, which can be used in research and therapeutic applications. | 2010-05-27 |
20100129916 | Expression of Toxic Genes In Vivo in a Non-Natural Host - Compositions and methods are provided for expression of a toxic protein in a host cell preferably a bacterial host cell where at least one T7 RNA polymerase gene Is contained on the host cell chromosome and one or more genes encoding a T7 RNA polymerase inhibitor is located on an F′ plasmid or on the chromosome. | 2010-05-27 |
20100129917 | METHOD AND INSTALLATION FOR DETERMINING AT LEAST ONE PARAMETER OF A PHYSICAL AND/OR CHEMICAL CONVERSION - A method, in which a succession of plugs (G) made of a physicochemical system capable of conversion in a carrier phase (P) is made to flow, in a tubular flow member ( | 2010-05-27 |
20100129918 | COMPOSITIONS AND METHODS FOR MONITORING BREAST CANCER TREATMENT - The present invention provides compositions and processes for preparing the same wherein the compositions are useful for monitoring breast cancer treatment. | 2010-05-27 |
20100129919 | METHODS AND BIOMARKERS FOR DIAGNOSING AND MONITORING PSYCHOTIC DISORDERS - A method of diagnosing or monitoring a psychotic disorder, or predisposition thereto, comprises measuring, in a sample taken from a subject, the level of a biomarker selected from clusterin precursor, inter α-trypsin inhibitor, IgM, apolipoprotein A2 and α2 H5 glycoprotein. | 2010-05-27 |
20100129920 | METHOD AND SYSTEM FOR MEASURING PHYSICAL PARAMETERS WITH A PIEZOELECTRIC BIMORPH CANTILEVER IN A GASEOUS OR LIQUID ENVIRONMENT - A piezoelectric bimorph cantilever is used for determining physical parameters in a gaseous or liquid environment. The sensor works as a driven and damped oscillator. Contrary to common cantilever sensor systems, the piezoelectric film of the bimorph cantilever acts as both a sensor and an actuator. Using at least two resonance mode of the bimorph cantilever, at least two physical parameters can be measured simultaneously in a gas or a liquid. An optimized piezoelectric cantilever and a method to produce the cantilever are also described. | 2010-05-27 |
20100129921 | MONITORING OF IONIC LIQUID CATALYST DEACTIVATION - A process for determining ionic liquid catalyst deactivation including (a) collecting at least one sample of an ionic liquid catalyst; (b) hydrolyzing the at least one sample to provide at least one hydrolyzed sample; (c) titrating the at least one hydrolyzed sample with a basic reagent to determine a volume of the basic reagent necessary to neutralize a Lewis acid species of the ionic liquid catalyst; and (d) calculating the acid content of the at least one sample from the volume of basic reagent determined in step (c) is described. Processes incorporating such a process for determining ionic liquid catalyst deactivation are also described. These processes are an alkylation process, a process for controlling ionic liquid catalyst activity in a reaction producing by-product conjunct polymers, and a continuous process for maintaining the acid content of an ionic liquid catalyst at a target acid content in a reaction producing by-product conjunct polymers. | 2010-05-27 |
20100129922 | DEVICES AND METHODS FOR THE COLLECTION AND DETECTION OF SUBSTANCES - The present invention provides a single self-contained device for collecting, extracting, on-site testing, and transferring for forensic confirmatory analysis, a wide variety of substances including, but not limited to, drugs of abuse, explosives, weapons of mass destruction, food toxins and industrial wastes. Samples can be obtained from a surface by swabbing a suspect area or the testing of solid materials (pills, capsules, powders), air samples and biological and non-biological fluids by placing the substance in the device. The device includes a swab, a retention well including a wash, and analysis technologies that can be, for example, a lateral flow testing system. The swab is rinsed with a wash prior to testing thereby not compromising the chemistry of the detection technologies and allowing for a wide variety of applications under a number of field conditions. Also, the device is a single self-contained unit instead of having a separate reagent droppers or sprays, making it compact and easy to use. Moreover, the device is designed to not only collect and test samples but to seal the originally target analyte, not affected by testing procedures, in a specially designed cap for shipping under chain of custody documentation to a forensic laboratory for confirmatory testing. | 2010-05-27 |
20100129923 | TANDEM MASS SPECTROMETRY FOR DETECTING AND/OR SCREENING FOR CONDITIONS ASSOCIATED WITH ALTERED STEROLS - Embodiments of the present invention provide for detecting and/or screening for conditions associated with altered sterols by dehvatization of sterols to provide suitable sensitivity and selectivity of detection using tandem mass spectrometry with electrospray ionization. Such testing may be performed to detect and/or screen for conditions such as Smith-Lemli-Opitz syndrome, familial hypercholesterolemia, and cerebrotendinous xanthomatosis, or certain bile acid disorders. | 2010-05-27 |
20100129924 | Quality assurance method for olefin polymerization catalysts - A method for evaluating the quality of an olefin polymerization catalyst is disclosed. A single-site organometallic complex is reacted with a methyl alumoxane under controlled reaction conditions. The extent and/or dynamics of methane formation from the reaction are measured, and the results are used to predict the suitability of the complex and/or the methyl alumoxane for use in an olefin polymerization. | 2010-05-27 |
20100129925 | SEMICONDUCTOR NANOWIRES CHARGE SENSOR - A semiconductor nanowire is coated with a chemical coating layer that comprises a functional material which modulates the quantity of free charge carriers within the semiconductor nanowire. The outer surface of the chemical coating layer includes a chemical group that facilitates bonding with molecules to be detected through electrostatic forces. The bonding between the chemical coating layer and the molecules alters the electrical charge distribution in the chemical coating layer, which alters the amount of the free charge carriers and the conductivity in the semiconductor nanowire. The coated semiconductor nanowire may be employed as a chemical sensor for the type of chemicals that bonds with the functional material in the chemical coating layer. Detection of such chemicals may indicate pH of a solution, a vapor pressure of a reactive material in gas phase, and/or a concentration of a molecule in a solution. | 2010-05-27 |
20100129926 | COPD DETERMINATION - There is provided a method of determining the status of chronic obstructive pulmonary disease (COPD) of a human. The method comprises (a) performing a spectral analysis of a sample collected from said human; (b) comparing the spectra produced by said analysis at (a) against a reference; and (c) determining the status of COPD in said human based upon any variations determined at (b). Also provided is an apparatus for determining COPD. | 2010-05-27 |
20100129927 | Peptides for Use in Diagnosing the Presence of Ruptured Atherosclerotic Lesions in a Individual - The present invention relates to peptides that are able to interact with ruptured atherosclerotic plaque-associated antibodies, which peptides comprise an immunoreactive part of one of the amino acid sequences according to SEQ ID NOS: 1-25. The invention further relates to a diagnostic reagent comprising the peptides, to the use of the method and to a method and test kit for the diagnosis of a sample from an individual for the presence therein of antibodies that are indicative of the presence of ruptured atherosclerotic plaques in the individual. | 2010-05-27 |
20100129928 | Tyrosine Phosphorylation Sites - The invention discloses 347 novel phosphorylation sites identified in carcinoma, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above. | 2010-05-27 |
20100129929 | Tyrosine Phosphorylation Sites - The invention discloses 349 novel phosphorylation sites identified in carcinoma, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above. | 2010-05-27 |