21st week of 2016 patent applcation highlights part 24 |
Patent application number | Title | Published |
20160145516 | Process for Producing Biodiesel and Related Products - There is described a process for producing biodiesel and related products from mixtures. There is also described a process for producing precursors and feedstock materials for producing biodiesel and related products. The processes use esterification and trans-esterification, separation and purification. Other process steps such as acidification and distillation can also be used. | 2016-05-26 |
20160145517 | METHOD FOR EXTRACTING NATURAL GAS LIQUIDS FROM NATURAL GAS USING AN ADSORBENT MEDIA COMPRISING A CROSS-LINKED MACROPOROUS POLYMER - A method is disclosed for the separation of ethane and heavier hydrocarbons or propane and heavier hydrocarbons from natural gas to provide a methane-rich natural gas stream and less volatile natural gas liquids (NGLs). This method provides for passing a natural gas feedstream though a regenerable adsorbent media which adsorbs the NGLs to provides the methane rich natural gas product. The regenerable adsorbent media of the present invention is a cross-linked macroporous polymeric adsorbent media. | 2016-05-26 |
20160145518 | OXYGEN AND SULFUR TOLERANT ADSORBENT SYSTEM - A process for treating a gas stream, such as natural gas, comprising a process design that prevents the formation of undesired sulfur and sulfates from the reaction of oxygen and sulfur is disclosed. After water is removed from the gas stream, a portion of the dried gas stream is sent through a cooled adsorbent bed that has a first layer to remove sulfur compounds and then a layer to remove oxygen. There may be additional layers of adsorbent to remove other contaminants. The gas stream that is then heated to regenerate an adsorbent bed no longer contains sulfur and oxygen and undesirable reactions of sulfur and oxygen are avoided. | 2016-05-26 |
20160145519 | CARBONIZED COMPONENT-BASED FUEL PELLET - With the rapid increase in the price of fossil fuels and growing concerns over climate change, the demand for renewable energy sources continues to increase. Densified biomass fuels are an alternative, renewable energy source that is becoming increasingly popular. A densified biomass with increased and controllable energy density is needed. Various embodiments of densified biomass and process to manufacture are taught herein. | 2016-05-26 |
20160145520 | METHOD AND DEVICE FOR TREATING TWO-PHASE FRAGMENTED OR PULVERIZED MATERIAL BY NON-ISOTHERMAL REACTIVE PLASMA FLUX - Method and device implemented in a reactor for the plasma treatment of carried fragmented material or of pulverized elements by a support gas where the main element is an intermediate temperature plasma (PIT) generator fed by a source of electric, pulses, the amplitude of whose current is limited and for which the generating frequency, the duration of the pulses and the duration of the time spans between the pulses are determined in such a way as to generate a nonthermal plasma (PIT) of large extent, the plasma and the carrier gas flux ( | 2016-05-26 |
20160145521 | Method for Producing Combustible Gas from Carbon Dioxide and Oxyhydrogen Gas - A new combustible gas is produced by reacting a gas mixture consisting of 90%-10% of carbon dioxide and 10%-90% of OHMASA-GAS under a pressure of 0.1 MPa-10 MPa at a temperature of 5° C.-50° C. | 2016-05-26 |
20160145522 | GREASE COMPOSITION AND ROLLING BEARING - There is provided a grease composition containing an edible oil as a base oil and calcium stearate as a thickener, wherein a structure stabilizer for preventing thermal hardening is added and an unworked penetration after heating at 100° C. for 100 hours is 77 or more, and a rolling bearing in which the grease composition is sealed. | 2016-05-26 |
20160145523 | COMPRESSOR OIL, METHOD FOR PRODUCING COMPRESSOR OIL, METHOD FOR COMPRESSING HYDROGEN, METHOD FOR GENERATING ELECTRIC POWER, AND METHOD FOR SUPPLYING HYDROGEN - The present invention provides a compressor oil comprising a hydrocarbon oil having the sulfur content of 0.1% or less by mass and the aromatic content of 1% or less by mass, wherein the content of hydrocarbons having 10 or less carbon atoms is 100 ppm or less by mass based on the total amount of the compressor oil. | 2016-05-26 |
20160145524 | Lubricating Composition Containing Viscosity Modifier Combination - The present invention relates to a lubricating composition containing (a) an oil of lubricating viscosity, (b) a star polymer and (c) a substantially linear polymer with a weight average molecular weight of 45,000 or less. The invention further provides a method of lubricating a mechanical device, typically a manual transmission with the lubricating composition. The invention further provides for the use of the lubricating composition to provide a number of benefits including lower operating temperatures and fuel economy. | 2016-05-26 |
20160145525 | COMPLEX POLYESTER COMPOSITION, LUBRICANT COMPOSITION, LUBRICANT, AND PRODUCTION METHOD FOR COMPLEX POLYESTER COMPOSITION - An object of the present invention is to provide a lubricant which has excellent lubrication performance and is able to exhibit excellent lubrication performance even when under extreme pressure conditions. The present invention relates to a complex polyester composition containing polyester obtained by condensing polyhydric alcohol having at least two hydroxyl groups, a dicarboxylic acid having 44 carbon atoms, and monohydric alcohol. Further, the present invention relates to a lubricant composition containing the complex polyester composition, and a lubricant and a production method for a complex polyester composition. | 2016-05-26 |
20160145526 | PRODUCTION METHOD FOR COMPLEX POLYESTER COMPOSITION, COMPLEX POLYESTER COMPOSITION, LUBRICANT COMPOSITION, AND LUBRICANT - An object of the present invention is to provide a lubricant having excellent lubrication performance. Further, another object of the present invention is to produce a polyester composition having a small load on an environment and mass productivity. The present invention relates to a production method for a complex polyester composition including a step of obtaining a complex polyester composition by condensing polyhydric alcohol, polycarboxylic acid having at least two carboxyl groups and carbon atoms of greater than or equal to 5, monohydric alcohol having at least one oxyalkylene group in the absence of a solvent, in which a component having a weight average molecular weight of less than or equal to 1300 in a GPC chart of the complex polyester composition is less than or equal to 43 area %. Further, the present invention relates to a complex polyester composition, a lubricant composition, and a lubricant. | 2016-05-26 |
20160145527 | THERMOSETTING RESIN COMPOSITION, SLIDING MEMBER AND METHOD FOR PRODUCING SLIDING MEMBER - There is provided a thermosetting resin composition including: an epoxy compound having an isocyanuric acid ring represented by the following formula (1); a solid lubricant; and a diisocyanate compound, or the diisocyanate compound and a bismaleimide compound. | 2016-05-26 |
20160145528 | LUBRICATING OIL ADDITIVE AND LUBRICATING OIL COMPOSITION - A lubricating oil additive comprising an organic molybdenum compound represented by general formula (1) below: (1) Wherein in formula (1), R1 denotes a straight chain or branched chain alkyl group represented by the general formula C | 2016-05-26 |
20160145529 | LUBRICATING COMPOSITION CONTAINING AN AROMATIC COMPOUND - The invention provides a lubricating composition containing an aromatic compound and an oil of lubricating viscosity. The invention further relates to the use of the lubricating composition in an internal combustion engine. The invention further relates to the use of the aromatic compound as an antiwear agent. | 2016-05-26 |
20160145530 | FUNCTIONALIZED OLEFIN COPOLYMERS WITH MONOAMINE TERMINATED POLYETHER AND LUBRICATING OIL COMPOSITIONS - A method for is disclosed for improving diesel engine wear by lubricating the engine with a composition comprising an oil of lubricating viscosity and based upon the total composition of the lubricating oil composition from about 0.1 to about 2.0 weight % actives of a reaction product of an ethylene-alpha olefin copolymer acylated with maleic anhydride having a number average molecular weight from 5,000 to 120,000 and a hydrocarbyl-substituted poly(oxyalkylene) monoamine represented by the formula: R | 2016-05-26 |
20160145531 | Method to Produce Catalytically Active Nanocomposite Coatings - A nanocomposite coating and method of making and using the coating. The nanocomposite coating is disposed on a base material, such as a metal or ceramic; and the nanocomposite consists essentially of a matrix of an alloy selected from the group of Cu, Ni, Pd, Pt and Re which are catalytically active for cracking of carbon bonds in oils and greases and a grain structure selected from the group of borides, carbides and nitrides. | 2016-05-26 |
20160145532 | Compositions and Use Thereof for Metal Shaping - The present invention provides metal shaping compositions and processes for using same for shaping metal substrates. Specifically, the metal shaping composition discussed herein are environmentally-friendly, water-containing composition which provide excellent lubricity under metal shaping process conditions while also providing excellent rust protection. The metal shaping compositions discussed herein contain (i) a film-forming lubricant capable of being solubilized into water in dispersible or emulsifiable form and which softens at a temperature of about 80 to about 200° C.; (ii) a film forming polymeric binder capable of being solubilized into water in dispersible or emulsifiable form; (iii) a solid lubricant capable of being solubilized into water in dispersible or emulsifiable form; and (iv) a corrosion inhibitor. | 2016-05-26 |
20160145533 | METHOD FOR EXTRACTING ORGANIC SOLIDS AND OIL FROM MARINE ORGANISMS ENRICHED WITH ASTAXANTHIN - A method is for extracting shrimp oil. Particularly, shrimp processing water (EPC) is recovered and subjected to a dissolved air flotation (DAF) system after adding a flocculating agent. The suspended and dissolved solids form aggregates that are recovered from the surface by a procedure referred to as “skimming”. The skimming product is then directed into a horizontal centrifuge (decanter) in order to separate the solid phase (SOC) and the liquid phase having water and shrimp oil. The liquid phase is pumped into the 3-phase vertical centrifuge in order to separate the shrimp oil, the water, and the solids. The solids recovered after using the separator can then be added to the solid phase obtained after settling. The resulting shrimp oil is very rich in astaxanthin and the resulting water contains very little organic material and can be returned to the general processing plant effluent. | 2016-05-26 |
20160145534 | POLYSILOXANE CONJUGATES AS FRAGRANCE DELIVERY SYSTEMS - The present invention relates to the field of perfumery. More particularly, it concerns polymers derived from siloxane derivatives and comprising at least one β-thio carbonyl moiety capable of liberating an active molecule such as, for example, an α,β-unsaturated ketone or aldehyde. The present invention concerns also the use of polymers in perfumery as part of a perfuming or malodor counteracting composition as well as the perfuming compositions or perfumed articles comprising the invention's compounds. | 2016-05-26 |
20160145535 | Compositions Comprising Encapsulated Actives within Droplets and other Compartments - The present invention generally relates to microparticles and, in particular, to systems and methods for encapsulation within microparticles. In one aspect, the present invention is generally directed to microparticles containing entities therein, where the entities contain an agent that can be released from the microparticles, e.g., via diffusion. In some cases, the agent may be released from the microparticles without disruption of the microparticles. The entities may be, for instance, polymeric particles, hydrogel particles, droplets of fluid, etc. The entities may be contained within a fluid that is, in turn, encapsulated within the microparticle. The agent may be released from the entity into the fluid, and then from the fluid through the microparticle. In such fashion, the release of agent from the microparticle may be controlled, e.g., over relatively long time scales. Other embodiments of the present invention are generally directed to methods of making such microparticles, methods of using such microparticles, microfluidic devices for making such microparticles, and the like. | 2016-05-26 |
20160145536 | Methods and Devices for Producing Biodiesel and Products Obtained Therefrom - Methods and devices for economically producing a purified biodiesel product from feedstocks. Some embodiments of the methods comprise using at least one of a crude feedstock pretreatment process and a free fatty acid refining process prior to transesterification and the formation of crude biodiesel and glycerin. The crude biodiesel is then subjected to at least one biodiesel refining process which, in conjunction with feedstock pretreatment and free fatty acid refining produces a purified biodiesel product that meets multiple commercial specifications. A wide variety of feedstocks may be used to make biodiesel that otherwise would not meet the same commercial specifications, including corn oil, used cooking oil, poultry fats, fatty acid distillates, pennycress oil, and algal oils. The combination of feedstock refining and biodiesel refining processes is necessary to reduce problems associated with feedstocks having waxes, high free fatty acid levels, unacceptable color, high unsaponifiables levels, and high sulfur levels. | 2016-05-26 |
20160145537 | COMPOSITIONS TO BOOST FABRIC SOFTENER PERFORMANCE - Method for treating a textile under industrial and institutional fabric care conditions to impart softness within a single wash and/or rinse cycle are disclosed. More particularly, the present invention relates to a combination of a liquid or solid fabric conditioning composition and a softening booster for treating a textile to impart softness within a single wash and/or rinse cycle. Compositions employed therein are further disclosed | 2016-05-26 |
20160145538 | COMPOSITIONS TO BOOST FABRIC SOFTENER PERFORMANCE - Method for treating a textile under industrial and institutional fabric care conditions to impart softness within a single wash and/or rinse cycle are disclosed. More particularly, the present invention relates to a combination of a liquid or solid fabric conditioning composition and a softening booster for treating a textile to impart softness within a single wash and/or rinse cycle. Compositions employed therein are further disclosed | 2016-05-26 |
20160145539 | COMPOSITIONS TO BOOST FABRIC SOFTENER PERFORMANCE - Method for treating a textile under industrial and institutional fabric care conditions to impart softness within a single wash and/or rinse cycle are disclosed. More particularly, the present invention relates to a combination of a liquid or solid fabric conditioning composition and a softening booster for treating a textile to impart softness within a single wash and/or rinse cycle. Compositions employed therein are further disclosed. | 2016-05-26 |
20160145540 | Detergent Compositions Comprising Metalloproteases - The present invention relates to the use of and compositions comprising isolated polypeptides having protease activity and polynucleotides encoding the polypeptides. The invention also relates to cleaning compositions, and the use of the polypeptides in cleaning processes. | 2016-05-26 |
20160145541 | Bleach Catalyst Granules, Use Thereof and Washing Cleaning Agents Containing the Same - The invention relates to a bleach catalyst granules containing a metal-containing bleach catalyst, which comprises at least one ligand selected from the group comprising di- or trimethyltriazcyclononanes or derivatives therefrom, and a homo- or copolymer polycarboxylate, salts thereof or partially neutralized having a pH-value of between 3 and 9. Said granules are produced in an anhydrous granulation process, in particular by compacting, the treatment temperature being maintained at below 100° C. | 2016-05-26 |
20160145542 | Cleaning Composition - This invention relates to cleaning compositions with controlled dissolution and improved chelation system. The cleaning composition is generally comprised of a majority by weight of a percarbonate compound, a chelation system, and a binder system. The invention also relates to non-oxidizing solid cleaning compositions containing peroxide moieties. These compositions are ideal for use in cleaning appliances, such as automatic washing machines and dishwashers. | 2016-05-26 |
20160145543 | CLEANING POUCH - A single or multi-compartment water-soluble cleaning pouch comprising a cleaning composition and an enveloping material, the pouch comprising at least one compartment comprising a liquid composition said liquid composition comprising a mixture of a first complexing agent and a second complexing agent wherein the first complexing agent is selected from the group consisting of methyl glycine diacetic acid, its salts and mixtures thereof and wherein the mixture of the complexing agents comprises at least 10% by weight thereof of the first complexing agent and the liquid composition has an eRH of about 65% or less at 20° C. | 2016-05-26 |
20160145544 | CLEANING POUCH - A single or multi-compartment water-soluble cleaning pouch comprising a cleaning composition and an enveloping material, the pouch comprising at least one compartment comprising a liquid composition said liquid composition comprising a mixture of a complexing agent and an eRH reducing agent wherein the complexing agent is selected from the group consisting of methyl glycine diacetic acid, its salts and mixtures thereof and the eRH reducing agent is a salt of an organic acid selected from the group consisting of mono-, di-carboxylic acids and mixtures thereof. | 2016-05-26 |
20160145545 | CLEANING POUCH - A single or multi-compartment water-soluble cleaning pouch comprising a cleaning composition and an enveloping material, the pouch comprising at least one compartment comprising a liquid composition said liquid composition comprising an aminocarboxylic complexing agent wherein the composition has a pH of from about 10 to about 11 as measured as a 1% aqueous solution at 22° C. | 2016-05-26 |
20160145546 | CLEANING POUCH - A single or multi-compartment water-soluble cleaning pouch comprising a cleaning composition and an enveloping material, the pouch comprising at least one compartment comprising a liquid composition said liquid composition comprising
| 2016-05-26 |
20160145547 | Film-Encased Cleaning Composition - This invention relates to a cleaning composition encased within a film material. The film-encased cleaning composition is useful for cleaning appliances, such as washing machines. | 2016-05-26 |
20160145548 | CLEANING COMPOSITION REFILL FOR AN AUTOMATIC DISHWASHER DISPENSING DEVICE - A cleaning composition dispensing device for use in an automatic dishwasher is provided for dispensing the right cleaning composition at the right time during a wash cycle. The device includes wash cycle sensing system that controls the release of cleaning composition via temperature and water flow data measured with respect to time. The device includes a refill compartment receiving a multi-section refill including at least two cleaning composition sections divided by separable seams. The multi-section refill separates into individual cleaning composition sections during placement in the refill compartment that fall into the slots forming the refill compartment. | 2016-05-26 |
20160145549 | SYSTEM AND METHOD FOR HAZARDOUS DRUG SURFACE CLEANING - The present invention relates to a method of cleaning a surface contaminated with a hazardous drug product involving cleaning in succession with a quaternary ammonium solution and an isopropyl alcohol solution. | 2016-05-26 |
20160145550 | Device And Method For Extracting Aroma Substances From Vegetable Aroma Carriers Into A Brewing Liquid - A device for extracting aroma substances from vegetable aroma carriers into a brewing liquid, in particular into beer, includes a fluidized bed extractor accommodating a suspension bed including the brewing liquid and solid particles contained in aroma carriers. The fluidized bed extractor has at least an inlet and an outlet for the brewing liquid. A feed pump pumps the brewing liquid from the inlet through the fluidized bed extractor to the outlet. A feeding speed of the feed pump is set to a value at which an average vertical feeding speed of the brewing liquid in the fluidized bed extractor is lower than an average vertical sedimentation speed of the solid particles in the fluidized bed extractor. | 2016-05-26 |
20160145551 | PICK UP TUBE ASSEMBLY USEFUL FOR FLUID TRANSFER INCLUDING LIQUID TRANSFER IN ALCOHOLIC BEVERAGE BREWING OPERATIONS - The present invention relates to a plumbing connection useful in the field of fluid transfer, including in many stages of beer brewing operations, to connect to a fluid inlet or outlet in which the plumbing connection includes a threaded, compressible bushing that compressibly grips a tube when tightened to make a plumbing connection. | 2016-05-26 |
20160145552 | FLOATING PHOTOBIOREACTOR SYSTEM COMPRISING A FLOATING PHOTOBIOREACTOR AND AN INTEGRATED PADDLE WHEEL AND AN AIRLIFT AND METHODS OF USE - This invention relates to a floating photobioreactor system comprising a floating photobioreactor and an integrated paddle wheel and an integrated airlift. This invention further relates to methods of using the floating photobioreactor system. | 2016-05-26 |
20160145553 | MODULAR PLATFORM FOR MULTI-TISSUE INTEGRATED CELL CULTURE - The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the organ systems are fluidically connected with a constant-volume pump. | 2016-05-26 |
20160145554 | INTEGRATED HUMAN ORGAN-ON-CHIP MICROPHYSIOLOGICAL SYSTEMS - The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems. | 2016-05-26 |
20160145555 | SYSTEMS AND METHODS FOR CELL CULTURE DEVICE INTERCONNECTION AND FLUIDIC DEVICE INTERCONNECTION - Systems and methods interconnect cell culture devices and/or fluidic devices by transferring discrete volumes of fluid between devices. A liquid-handling system collects a volume of fluid from at least one source device and deposits the fluid into at least one destination device. In some embodiments, a liquid-handling robot actuates the movement and operation of a fluid collection device in an automated manner to transfer the fluid between the at least one source device and the at least one destination device. In some cases, the at least one source device and the at least one destination device are cell culture devices. The at least one source device and the at least one destination device may be microfluidic or non-microfluidic devices. In some cases, the cell culture devices may be microfluidic cell culture devices. In further cases, the microfluidic cell culture devices may include organ-chips. | 2016-05-26 |
20160145556 | AXENIC INOCULATION SYSTEM FOR MICROALGAE USING TR TUBE OF TRIIODIDE RESIN AND METHOD FOR CULTURING AXENIC CULTURE - A triiodide resin (TR) tube of the present invention has a cylindrical shape. A resin exhaust preventing part is provided at a lower portion of the TR tube, and a triiodide resin is received inside the TR tube. A contaminated culture passes through the TR tube to allow an axenic culture to flow out. When a microalgae culture contaminated with bacteria passes through the TR tube filled with the triiodide resin, a pure culture of microalgae can be prepared by using the sterilizing rate of bacteria populations, which is relatively higher than that of microalgae, due to characteristics of iodine exhibiting negative polarity. An axenic inoculation system for microalgae using the TR tube of the present invention comprises the steps of: sterilizing a photobioreactor (PBR) with peracetic acid, washing the PBR with purified water, and filling the PBR with a sterilized culture; allowing a microalgae culture contaminated with bacteria to pass through a TR tube attached on an upper portion of the PBR, thereby obtaining an axenic culture; and inoculating the axenic culture into a culture liquid inside the PBR to culture microalgae. According to the present invention, the microalgae contaminated with bacteria are sterilized together with bacteria in external air flowing in the TR tube while passing through the TR tube, thereby causing no secondary contamination at the time of inoculation or culture. | 2016-05-26 |
20160145557 | Reactor vessel useful for performing multiple pretreatments - The present invention provides for a reactor vessel comprising a reaction chamber comprising an inner surface configured for performing multiple pretreatments. | 2016-05-26 |
20160145558 | CO-INCUBATING CONFINED MICROBIAL COMMUNITIES - This invention provides devices and methods that enable co-incubation of microorganisms. Also provided are methods of making such devices for co-incubation of microorganisms, and various applications of such devices. | 2016-05-26 |
20160145559 | METHOD OF OPERATING CONTINUOUS STERILIZING APPARATUS, CONTINUOUS STERILIZING APPARATUS, FERMENTING SYSTEM, AND CONTINUOUS FERMENTING SYSTEM - A continuous sterilizing apparatus circulates, through members constituting a flow channel, a sterilizing medium that sterilizes the members to sterilize the members, circulates a sterilizing liquid subjected to sterilization treatment through pipes, performs a series of pieces of treatment including heating treatment, holding treatment, and cooling treatment on the sterilizing liquid, controls a flow rate, a temperature, and a pressure to be preset conditions, and switches a liquid to be circulated through the flow channel from the sterilizing liquid to a liquid to be sterilized. | 2016-05-26 |
20160145560 | DEVICE FOR MICROBIAL CULTIVATION WITH OPTIONS FOR FIELD STERILIZATION AND GAS GENERATION - A microbiological cultivation method, and a device for its use is equipped with field-capable system for producing optimal culture conditions for aerobic, microaerobic and anaerobic microbes. They are further equipped with possibilities for independent clean up and sterilization, as well as for gas supply, generation and regulation. This device and method can be used for clinical, environmental and industrial microbial monitoring tasks. | 2016-05-26 |
20160145561 | BIOREACTOR SYSTEM WITH A TEMPERATURE SENSOR - A bioreactor system comprising a base station comprising a control system, a tray arranged to be provided on the base station and arranged to house a bioreactor bag, wherein said base station comprises at least one temperature sensor means and in that said tray comprises at least one opening for receiving said temperature sensor means such that it will contact a surface of a bioreactor provided in the tray. | 2016-05-26 |
20160145562 | A DEVICE FOR MONITORING THE DEVELOPMENT OF A BIOLOGICAL MATERIAL - The present invention relates to a device ( | 2016-05-26 |
20160145563 | DISTRIBUTED PERFUSION BIOREACTOR SYSTEM FOR CONTINUOUS CULTURE OF BIOLOGICAL CELLS - Embodiments provide a distributed bioreactor system in which a plurality of modular bioreactors are operated in parallel to produce and maintain a biological cell culture. A central or nurse perfusion bioreactor produces and maintains a cell culture and transfers portions of the cell culture to a plurality of modular peripheral perfusion bioreactors, each of which produces and maintains the cell culture in turn. In order to prevent contamination and facilitate segregation of particular peripheral bioreactors, the distributed system is configured such that one-way fluid communication is established from the central/nurse bioreactor to each of the peripheral bioreactors while maintaining fluid isolation among the peripheral bioreactors. Each modular peripheral bioreactor unit has a plug-and-play configuration and may be plugged into or otherwise coupled to the central/nurse bioreactor to scale up the over-all size of the cell culture without requiring sterilization or redesign or reconfiguration of the system. | 2016-05-26 |
20160145564 | MICROBIAL MATERIAL FOR REDUCING SOIL/WATER QUALITY CONTAMINATION, RESTRICTING WARMING GAS GENERATION, AND IMPROVING PLANT FUNCTION, AND METHOD FOR MANUFACTURING FERMENTATION PRODUCT - Provided are a functional microbial material and a method for producing a fermentation product, wherein the functional microbial material and the fermentation product are environment-friendly and improve the quality of crops. The present invention relates to a microbial material and a method for producing a fermentation product wherein the microbial material and the fermentation product are obtained by fermentation of a fermentation raw material including a plant-derived raw material and an animal-derived raw material using a population of microorganisms including a plurality of species of thermophilic microorganisms, and lead to a remedy for soil and water pollution and to the inhibition of greenhouse gas generation, as well as contribute to improvements in the functionality of plants, particularly the expression of genes involved in biophylaxis and resistant to high-temperature disorder, and an increase in antioxidant components. Quality enhancement of plants is promoted without genetic recombination, using a population of microorganisms that have a function to restore the environment and a function as an elicitor for the plant. Further, burdens on the natural environment are maintained and restored through normal production activities. | 2016-05-26 |
20160145565 | CELL CULTURE MEDIA - The present invention relates to cell culture media comprising polymer embedded components. Some components show poor stability in dry powder cell culture media. Others are hygroscopic. Such components can be embedded into polymers to increase stability and reduce clumping | 2016-05-26 |
20160145566 | RECONFIGURABLE ASSEMBLY WITH FARADAY WAVE-BASED TEMPLATES - A method manufactures a structure based on reconfigurable assembly with faraday wave-based templates. The method includes the steps of providing a chamber containing a gas-liquid interface or liquid-liquid interface and dispersing a plurality of floaters at the gas-liquid interface or liquid-liquid interface. The method further includes oscillating the chamber along an axis orthogonal to the gas-liquid interface or liquid-liquid interface, thereby generating a standing wave formed by a parametric instability on the surface of the liquid. After formation of the standing wave, the floaters are allowed to self-assemble, at which point the floaters can be linked together. | 2016-05-26 |
20160145567 | CELL CULTURE ARTICLE AND METHODS THEREOF - A cell culture article, including: a substrate comprising a polygalacturonic acid compound selected from at least one of: pectic acid; partially esterified pectic acid having a degree of esterification from 1 to 40 mol %, or salts thereof; and an adhesion polymer on the surface of the polygalacturonic acid compound. A method of making and using the article are also disclosed. | 2016-05-26 |
20160145569 | Compositions and Methods Useful for Culturing Differentiable Cells - The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand. | 2016-05-26 |
20160145570 | METHODS FOR DIFFERENTIATING CELLS INTO HEPATIC STELLATE CELLS AND HEPATIC SINUSOIDAL ENDOTHELIAL CELLS, CELLS PRODUCED BY THE METHOD, AND METHODS FOR USING THE CELLS - The invention is directed to methods for culturing cells so that the cells are induced to differentiate into cells that express a hepatic stellate phenotype and cells that express a hepatic sinusoidal endothelial phenotype. The invention is also directed to cells produced by the methods of the invention. The cells are useful, among other things, for treatment of liver deficiency, liver metabolism studies, and liver toxicity studies. | 2016-05-26 |
20160145571 | COMPOSITIONS FOR CELLULAR RESTORATION AND METHODS OF MAKING AND USING SAME - A method comprising obtaining a donor composition from a donor subject wherein the donor composition comprises a plurality of adult stem cell types; obtaining a receiver composition from a receiver subject wherein the receiver composition comprises a plurality of adult stem cell types; and co-culturing the donor composition and receiver composition wherein co-culturing comprises contacting the receiver composition a cell-free portion of the donor composition to produce a restored composition. Pharmaceutical compositions comprising a restored composition. | 2016-05-26 |
20160145572 | Differentiated Pluripotent Stem Cell Progeny Depleted of Extraneous Phenotypes - The invention provides methods for depleting extraneous phenotypes from a mixed population of cells comprising the in vitro differentiated progeny of primate pluripotent stem cells. The invention also provides mixed cell populations enriched for a target cell phenotype where the mixed cell population comprises the differentiated in vitro progeny of primate embryonic stem cells. | 2016-05-26 |
20160145573 | Platelet Protection Solution Having a Beta-Galactosidase Inhibitor - The present invention relates to a platelet protection solution (PPS) having an amount of one or more β-galactosidase inhibitors with or without an amount of one or more sialidase inhibitors, and optionally one or more glycan-modifying agents; and one or more of PPS components that include a salt, a citrate source, a carbon source, or any combination thereof. | 2016-05-26 |
20160145574 | KIT AND METHOD FOR PROMOTING MESENCHYMAL STEM CELL DIFFERENTIATION - The present invention is related to a kit comprising: (a) a mesenchymal stem cell; (b) a gelatin-hyaluronan-chondroitin tri-copolymer scaffold; (c) a kartogenin; and (d) a bioreactor. The present invention is also related to a method for promoting differentiation of a mesenchymal stem cell into cartilage tissue, comprising: (a) culturing the mesenchymal stem cell on a gelatin- hyaluronan-chondroitin tri-copolymer scaffold in the presence of a kartogenin; and (b) culturing the mesenchymal stem cell and the gelatin-hyaluronan-chondroitin tri-copolymer scaffold in a bioreactor. | 2016-05-26 |
20160145575 | METHODS OF GENERATING CELLS WITH MULTILINEAGE POTENTIAL - The present invention relates to methods for generating mammalian multilineage-potential cells, including mesenchymal stem cells, comprising contacting mammalian somatic cells exhibiting a mature phenotype with PDGF-AB or functional derivative, fragment or mimetic thereof and Azacitidine or functional derivative or analogue thereof for a time and under conditions sufficient to induce the transition of the somatic cells to cells exhibiting multilineage differentiative potential. Also provided are uses of said multilineage-potential cells, such as in promoting tissue repair and regeneration. | 2016-05-26 |
20160145576 | METHODS OF PRODUCING STEM CELL CONDITIONED MEDIA - Methods of producing stem cell conditioned media to treat mammalian injuries or insults. In at least one embodiment of a method of producing a stem cell conditioned media of the present disclosure, the method comprises the steps of culturing at least one stem cell in a first cell culture medium, replacing some or all of the first cell culture medium with a second cell culture medium and further culturing the at least one stem cell in the second cell culture medium, and collecting a quantity of the second cell culture medium after a culture duration, wherein the quantity of the second cell culture medium contains a cell culture byproduct effective to treat a mammalian insult or injury. | 2016-05-26 |
20160145577 | HUMAN MULTIPOTENT EMBRYONIC STEM CELL-LIKE PROGENITOR CELLS - The invention provides a plurality of embryonic stem cell-like progenitor cells, which are isolated from a human tissue by a systemic screening of human mesenchymal stromal stem/progenitor cells and a cell sorting by a cell antigen selected from the group consisting of CD34, CD117, CD133, CD201, GloboH and combination thereof, and cultured in a medium supplemented with at least one or more steroids and one or more growth factors. The cells of the invention express CD34 and exhibit sphere-like clonogenicity in early passages and express multipotent embryonic stem cells (ESCs) like characteristics. | 2016-05-26 |
20160145578 | METHOD FOR DIFFERENTIATION OF PLURIPOTENT STEM CELLS INTO MULTI-COMPETENT RENAL PRECURSORS - This application relates to a method for differentiating pluripotent stem cells (PSCs) into multi-competent renal precursor cells expressing Six2. These renal precursor cells are able to differentiate into fully functional and fully differentiated podocytes. Moreover this application relates to a method for differentiating human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) into defined renal precursor cells expressing Six2 and podocytes based on linked steps of chemically defined medium inductions. | 2016-05-26 |
20160145579 | REGULATING STEM CELLS - Provided are methods for producing progenitor/precursor cells from a population of initiating cells (ICP) that have a density of less than 1.072 g/ml and at least 25% of which are CD31Bright by in vitro stimulating the ICP with different factors. | 2016-05-26 |
20160145580 | METHOD OF CULTURING CANCER STEM CELLS - There is provided a method for culturing a population of cancer stem cells. The method comprises introducing the cancer stem cells on or in a cell culture substrate, the cell culture substrate being in the form of a gel comprising a conjugate of a glycosaminoglycan and a substituted phenalkylamine. | 2016-05-26 |
20160145581 | COMPOSITIONS AND METHODS FOR REPROGRAMING NON-PLURIPOTENT CELLS INTO PLURIPOTENT STEM CELLS - The invention provides a composition and a method for inducing pluripotency in non-pluripotent eukaryotic cells. The composition comprises chemical inducers of pluripotency (CIPs) including glycogen synthase kinase (GSK) inhibitors, TGFp receptor inhibitors, cyclic AMP agonists, S-adenosylhomocysteine hydrolase (SAH) inhibitors, and optionally an agent that promotes histone acetylation. The method comprises contacting a cell with the CIPs for a sufficient period of time to reprogram the cell into a pluripotent stem cell. | 2016-05-26 |
20160145582 | EPISOMAL REPROGRAMMING WITH CHEMICALS - Methods and composition of induction of pluripotent stem cells are disclosed. For example, in certain aspects methods for generating essentially vector-free induced pluripotent stem cells with cell signaling regulators are described. Furthermore, certain aspects of the invention provide novel compositions comprising induced pluripotent stem cells essentially free of exogenous retroviral vector elements in the presence of a medium comprising signaling inhibitors. In certain aspects, feeder-free episomal reprogramming methods may be provided. | 2016-05-26 |
20160145583 | Methods for Preparing Inactivated Rotavirus - Disclosed are methods for production of inactivated rotavirus directly from cell culture supernatants containing active or infectious rotavirus (e.g., bovine rotavirus), without prior isolation or purification of the rotavirus from the cell culture supernatants In some embodiments, inactivated rotavirus (e.g., bovine rotavirus) is produced by heating a volume of culture supernatant to at least a temperature at which the rotavirus is inactivated. In some embodiments, the rotavirus (e.g., bovine rotavirus) is inactivated once the entire volume is heated to at least a temperature at which the rotavirus is inactivated. In some embodiments, the temperature of the cell culture supernatant is maintained for a suitable amount of time, which may be determined using any of the tests described herein. Inactivated rotavirus (e.g., bovine rotavirus) may then be isolated from the culture supernatant. | 2016-05-26 |
20160145584 | MUTATED REP ENCODING SEQUENCES FOR USE IN AAV PRODUCTION - Nucleic acids encoding Parvoviral Rep proteins with a mutated nuclear localization signal (NLS) are provided. Also provided is a nucleic acid comprising a nucleotide sequence encoding a Parvoviral Rep protein with a mutated zinc finger domain and a nucleic acid comprising a nucleotide sequence encoding a Parvoviral Rep protein comprising an amino acid mutation at position 43, 57, 79, 97, 120, 179, 305, 484, 493 or 571 with reference to SEQ ID NO: 2. Nucleic acid constructs and cells, such as insect cells, comprising the nucleic acids are provided as well as a method for producing a recombinant Parvoviral virion using the nucleic acids. | 2016-05-26 |
20160145585 | PROTEIN HAVING NADH AND/OR NADPH OXIDASE ACTIVITY - Water-forming NADH oxidase derived from | 2016-05-26 |
20160145586 | AAD-1 EVENT DAS-40278-9, RELATED TRANSGENIC CORN LINES, AND EVENT-SPECIFIC IDENTIFICATION THEREOF - This invention relates in part to plant breeding and herbicide tolerant plants. This invention includes a novel aad-1 transformation event in corn plants comprising a polynucleotide sequence, as described herein, inserted into a specific site within the genome of a corn cell. In some embodiments, said event/polynucleotide sequence can be “stacked” with other traits, including, for example, other herbicide tolerance gene(s) and/or insect-inhibitory proteins. Additionally, the subject invention provides assays for detecting the presence of the subject event in a sample (of corn grain, for example). The assays can be based on the DNA sequence of the recombinant construct, inserted into the corn genome, and on the genomic sequences flanking the insertion site. Kits and conditions useful in conducting the assays are also provided. | 2016-05-26 |
20160145587 | ARGININE IMPROVES POLYMERASE STORAGE STABILITY - Liquid storage solutions comprising polymerases are provided. | 2016-05-26 |
20160145588 | Novel DNA-Ploymerases - The technology provided herein relates to novel variants of DNA-Polymerases exhibiting high termo-stability as well as a strong strand displacement activity; to nucleic acid molecules encoding said DNA-Polymerases, vectors, host cells containing the nucleic acids and methods for preparation and producing such enzymes; compositions comprising at least one of the DNA-Polymerases; and methods for using such enzymes in DNA sequencing and/or DNA amplification processes. | 2016-05-26 |
20160145589 | COMPOSITION AND FORMULATION COMPRISING RECOMBINANT HUMAN IDURONATE-2-SULFATASE AND PREPARATION METHOD THEREOF - A composition comprising recombinant iduronate-2-sulfatase (IDS) and a method for producing a purified recombinant IDS are provided. The glycosylation pattern and formylglycine content of the IDS composition are different from those of ELAPRASE® and have superior pharmaceutical efficacy and are safer than the conventional agent and thus can be effectively used for the therapy of Hunter syndrome. | 2016-05-26 |
20160145590 | CYTOLETHAL DISTENDING TOXIN SUBUNIT B CONJUGATED OR FUSED TO BACILLUS ANTHRACIS TOXIN LETHAL FACTOR - Disclosed is a protein comprising a cytolethal distending toxin subunit B (CdtB) conjugated or fused to a | 2016-05-26 |
20160145591 | BACTERIAL LYSINS AND USES THEREOF - The present invention relates to substances and compositions thereof useful in the prevention and/or treatment of bacterial infections and disorders, in particular bacteremia caused by group B | 2016-05-26 |
20160145592 | GLUCOAMYLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME - The present invention relates to glucoamylase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants. | 2016-05-26 |
20160145593 | HEAT STABLE KERATINASE AND USE THEREOF - A fusion gene encoding | 2016-05-26 |
20160145594 | Protease Variants and Polynucleotides Encoding Same - The present invention relates to protease variants and methods for obtaining protease variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants. | 2016-05-26 |
20160145595 | Subtilase Variants and Polynucleotides Encoding Same - The present invention relates to novel subtilase variants exhibiting increased stability and optionally on par or improved wash performance. The variants of the invention are suitable for use in e.g. cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions. The present invention also relates to isolated DNA sequences encoding the variants, expression vectors, host cells, and methods for producing and using the variants of the invention. | 2016-05-26 |
20160145596 | Subtilase Variants and Polynucleotides Encoding Same - The present invention relates to novel subtilase variants exhibiting increased stability and preferably on par or improved wash performance. The variants of the invention are suitable for use in e.g. cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions. The present invention also relates to isolated DNA sequences encoding the variants, expression vectors, host cells, and methods for producing and using the variants of the invention. | 2016-05-26 |
20160145597 | HEPARIN AFFINITY TAG AND APPLICATIONS THEREOF - In one aspect, affinity tags for recombinant protein purification are described herein which, in some embodiments, can mitigate or overcome disadvantages of prior affinity tag systems. In some embodiments, for example, affinity tags described herein permit efficient elution of desired recombinant proteins with simplified solution systems, such as alkali metal salt solutions. An affinity tag described herein comprises an amino acid sequence including a repeating amino acid unit of BXXXBXX, wherein B is an amino acid selected from the group consisting of histidine, lysine and arginine and X is an amino acid selected from the group consisting of amino acids other than histidine, lysine and arginine. | 2016-05-26 |
20160145598 | FACTOR X MUTANTS - The present invention concerns a protein comprising a mutated sequence of SEQ ID No. 1, said mutated sequence of SEQ ID No. 1 comprising at least one mutation A, A′, B, C or C′, in which:
| 2016-05-26 |
20160145599 | Mutant Yeasts Having an Increased Production of Lipids and of Citric Acid - The present invention relates to a mutant yeast strain, in which at least the expression or the activity of the 2-methyl-citrate dehydratase is inhibited, and to the use of said strain for the production of lipids and of citric acid. | 2016-05-26 |
20160145600 | MAGNETIC MICROCARRIERS - Magnetic microcarrier beads have a particle size of 1 to 1000 micrometers and include a composite core and a polymer coating that surrounds and encapsulates the core. The composite core includes magnetic particles embedded within an indigestible polymer matrix. The coating is a digestible or indigestible polymer that facilitates cell adhesion to the surface of the beads during cell culture. Magnetic force can be used to agitate the microcarrier beads during cell culture as well as to separate the beads from cultured cells or processed bio-media. | 2016-05-26 |
20160145601 | METHODS AND SYSTEMS FOR DNA ISOLATION ON A MICROFLUIDIC DEVICE - The present invention relates to methods and systems for the isolation of DNA on a microfluidic device and the subsequent analysis of the DNA on the microfluidic device. More specifically, embodiments of the present invention relate to methods and systems for the isolation of DNA from patient samples on a microfluidic device and use of the DNA for performing amplification reactions, such as PCR, and detection, such as thermal melt analysis, on the microfluidic | 2016-05-26 |
20160145602 | METHODS AND APPARATUSES FOR GENE PURIFICATION AND IMAGING - The present disclosure is directed to systems, devices and methods for nucleic acid or protein purification and imaging. A system is provided including a cartridge comprising a sample input area configured to hold a sample, comprising a plurality of hybridized complexes comprising a plurality of target molecules each hybridized with probes and a plurality of non-hybridized probes. The cartridge may also include a first binding chamber configured with first magnetic beads to receive and bind the sample, a first elution channel configured to receive the first magnetic beads and elute the sample from the first magnetic beads, a second binding chamber configured with second magnetic beads to receive and bind the sample, a second elution channel configured to receive the second magnetic beads and elute the sample from the second magnetic beads, and a binding area configured to receive the eluted sample and hold molecules for imaging. | 2016-05-26 |
20160145603 | COMPOSITIONS FOR MAKING RANDOM CODON-MUTANT LIBRARIES AND USES THEREOF - The present disclosure relates to compositions and methods for randomly introducing codon-mutations in a target nucleic acid molecule and, more particularly, using wild-type and triplet-randomized oligonucleotides to introduce mutations uniformly across a target nucleotide of interest in a controlled fashion and with a low rate of insertions or deletions. | 2016-05-26 |
20160145604 | An Integrated System for Library Construction, Affinity Binder Screening and Expression Thereof - A recombinant polynucleotide suitable for use in a display vector is provided. The recombinant polynucleotide includes from 5′ to 3′: a first nucleic acid sequence (or insert) encoding an amino acid sequence to be displayed on a surface; a first pre-selected restriction site; a second nucleic acid sequence encoding a surface peptide capable of being displayed on the surface; and a second pre-selected restriction site. Corresponding display vectors that can be converted into expression vectors in a high-throughput fashion, as well as methods of use thereof, are also provided. | 2016-05-26 |
20160145605 | PEPTIDE-PRESENTING PROTEIN AND PEPTIDE LIBRARY USING SAME - The object of the present invention is to provide a method for screening peptide(s) highly specific to a target molecule. The object can be solved by a peptide-presenting protein wherein a peptide is presented in a presentation region consisting of the 131st to 139th amino acids in the amino acid sequence of the SEQ ID NO: 54, wherein the peptide consisting of 4 to 15 amino acids is inserted in the 131st to 139th amino acids sequence, or substituted for any of 1 to 9 amino acid(s) sequence in the 131st to 139th amino acids sequence; and a total length of an amino acid sequence corresponding to the 131st to 139th amino acids sequence is 15 or less. | 2016-05-26 |
20160145606 | Nuclease-Resistant DNA Analogues - The present invention provides stable, nuclease-resistant TNA and TNA-DNA oligonucleotides, wherein the oligonucleotides are completely resistant to enzymatic degradation for at least 24-72 hours. Methods of synthesis and use in diagnostic and therapeutic applications are also provided. Specifically, in one embodiment, we describe the chemical and biological stability of TNA and mixed-backbone (mosaic) TNA-DNA oligonucleotides under a variety of conditions and sequence contexts. | 2016-05-26 |
20160145607 | MICRO-RNA FAMILY THAT MODULATES FIBROSIS AND USES THEREOF - The present invention relates to the identification of a microRNA family, designated miR-29a-c, that is a key regulator of fibrosis in cardiac tissue. The inventors show that members of the miR-29 family are down-regulated in the heart tissue in response to stress, and are up-regulated in heart tissue of mice that are resistant to both stress and fibrosis. Also provided are methods of modulating expression and activity of the miR-29 family of miRNAs as a treatment for fibrotic disease, including cardiac hypertrophy, skeletal muscle fibrosis other fibrosis related diseases and collagen loss-related disease. | 2016-05-26 |
20160145608 | MICRO-RNA FAMILY THAT MODULATES FIBROSIS AND USES THEREOF - The present invention relates to the identification of a microRNA family, designated miR-29a-c, that is a key regulator of fibrosis in cardiac tissue. The inventors show that members of the miR-29 family are down-regulated in the heart tissue in response to stress, and are up-regulated in heart tissue of mice that are resistant to both stress and fibrosis. Also provided are methods of modulating expression and activity of the miR-29 family of miRNAs as a treatment for fibrotic disease, including cardiac hypertrophy, skeletal muscle fibrosis other fibrosis related diseases and collagen loss-related disease. | 2016-05-26 |
20160145609 | MICRO-RNA FAMILY THAT MODULATES FIBROSIS AND USES THEREOF - The present invention relates to the identification of a microRNA family, designated miR-29a-c, that is a key regulator of fibrosis in cardiac tissue. The inventors show that members of the miR-29 family are down-regulated in the heart tissue in response to stress, and are up-regulated in heart tissue of mice that are resistant to both stress and fibrosis. Also provided are methods of modulating expression and activity of the miR-29 family of miRNAs as a treatment for fibrotic disease, including cardiac hypertrophy, skeletal muscle fibrosis other fibrosis related diseases and collagen loss-related disease. | 2016-05-26 |
20160145610 | COMPOSITIONS AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS - A compound comprising formula (I): | 2016-05-26 |
20160145611 | AGE-RELATED MACULAR DEGENERATION TREATMENT - This invention is directed to an RNA interference (RNAi) agent and the use of that RNAi agent to treat Age-related Macular Degeneration, as well as pharmaceutical compositions containing the RNAi agents of the invention. The RNAi agent is a DNA-directed RNA interference (ddRNAi) agent (being an RNA molecule), together with an expression cassette or construct to express that agent in a cell (including in vivo), for inhibiting, preventing or reducing expression of an AMD associated gene. Preferably that AMD associated gene is one that is associated with wet AMD. | 2016-05-26 |
20160145612 | DIAGNOSIS AND TREATMENT OF METABOLIC DISORDERS - A method or assay for determining whether an individual is a HNF1A-MODY carrier is described and comprising a step of assaying a biological sample from the individual to detect increased abundance of a micro RNA molecule selected from miR103, miR551b, or miR224, or detect decreased abundance of a micro RNA molecule selected from miR503, and miR539. Increased abundance of one or more of miR103, miR551b, or miR224 or decreased abundance of one or more of miR503 and miR539, indicates that the individual is a HNF1A-MODY carrier. A method for treating metabolic disorders, especially diabetes mellitus, is also described. | 2016-05-26 |
20160145613 | OLIGONUCLEOTIDE DUPLEXES COMPRISING DNA-LIKE AND RNA-LIKE NUCLEOTIDES AND USES THEREOF - Novel oligonucleotide pairs which can form a duplex comprising one or more DNA-like nucleotides (e.g., 2′-substituted arabinonucleotides (ANA)); in combination with one or more RNA-like nucleotides (e.g., 2′-substituted ribonucleotides (RNA) and/or locked nucleic acid nucleotides (LNA)), are disclosed. The use of such oligonucleotide duplexes, such as for silencing the expression of a nucleic acid or gene of interest using small interfering RNA (siRNA) technologies, is also disclosed. | 2016-05-26 |
20160145614 | DOUBLE-STRANDED AGENTS FOR DELIVERING THERAPEUTIC OLIGONUCLEOTIDES - Disclosed are double-stranded nucleic acid agents that can deliver a therapeutic oligonucleotide within a biological sample, and methods for using the same. In one embodiment, the double-stranded nucleic acid agent comprises a first strand comprising a first RNA region, and a second strand comprising a first DNA region, wherein said first RNA region and said first DNA region are hybridized as a RNA/DNA heteroduplex. Said first strand further comprises a nucleic acid therapeutic oligonucleotide region that is capable of being cleaved from at least one nucleotide in said first RNA region. Methods for using the double-stranded nucleic acid agents include methods for delivering the therapeutic oligonucleotide as a single strand by cleaving it from at least a portion of the first RNA region. The methods further include delivering the double-stranded nucleic acid agent and thus the therapeutic oligonucleotide to a target site within the body of a treatment subject. | 2016-05-26 |
20160145615 | AGONISTS OF DDAH1 FOR TREATING ENDOTHELIAL DYSFUNCTION - The present invention derives from the finding that expression of DDAH1 is heavily post-transcriptionally regulated by microRNAs. By preventing or blocking the interaction between such microRNAs and the DDAH1 mRNA, the production of DDAH1 protein can be increased. This has utility in the prevention or treatment of diseases and disorders that are associated with reduced DDAH1 levels or increased ADMA levels, such as diseases or disorders that are characterised by endothelial dysfunction. | 2016-05-26 |
20160145616 | INHIBITION OF MICRORNA FOR TREATMENT OF SEPSIS - A method of treating sepsis comprises administering an agent that inhibits the activity of an miRNA that is upregulated in sepsis. | 2016-05-26 |