21st week of 2012 patent applcation highlights part 45 |
Patent application number | Title | Published |
20120129112 | Method Of And A System For Combusting Fuel In An Oxyfuel Combustion Boiler - A method of and a system for combusting fuel in an oxyfuel combustion boiler. Fuel is fed to a furnace of the boiler. Oxidant gas that includes a mixture of substantially pure oxygen and recycled flue gas is fed to the furnace, prior to the feeding of the oxidant gas. At least a portion of the oxidant gas is preheated to generate preheated oxidant gas. The fuel is combusted with the oxidant gas in the furnace so as to generate steam and to produce the flue gas, and at least a portion of the steam is superheated to generate superheated steam. The preheating of the at least a portion of the oxidant gas is performed by using a heat exchanger that transfers heat from a portion of the superheated steam to the oxidant gas. | 2012-05-24 |
20120129113 | SYSTEM AND METHOD OF MANAGING ENERGY UTILIZED IN A FLUE GAS PROCESSING SYSTEM - A method for managing an amount of energy utilized by a carbon dioxide capture system that includes providing a fuel and a feed stream including oxygen to a combustion system. The feed stream includes a portion of a flue gas stream generated upon combustion of the fuel in the combustion system. The flue gas stream is subjected to a carbon dioxide capture system to remove carbon dioxide therefrom and an amount of at least one of an oxygen stream or the portion of the flue gas stream introduced to the feed stream is adjusted such that the feed stream maintains an oxygen concentration in a range of between 10% to 90% by volume and the carbon dioxide capture system operates at an energy load between about 1.4 GJ/ton of carbon dioxide and about 3.0 GJ/ton of carbon dioxide. | 2012-05-24 |
20120129114 | Candle Wick System - This invention relates to a candle wick system for use with a container, in particular, a system including a candle wick, a wick dip, utilized alone and in combination thereof; wherein the candle wick system is for use with a container populated by a fuel having a wick with a height, a variable cross-sectional area, and a thickness. | 2012-05-24 |
20120129115 | METHOD FOR CHANGING THE DIRECTION OF MAGNETIZATION IN FERROMAGNETIC LAYER - The invention provides a method of modifying the direction of magnetization of an upper layer ( | 2012-05-24 |
20120129116 | Removable Rodent Intraoral Device - A removable intraoral device is useful for longitudinal in vivo biofilm research. The device is adapted to allow it to be retained in the oral cavity long enough for biofilm to form and to affect the oral mucosa. The device is readily removable to facilitate longitudinal observations. The device is biostable. The device does not interfere with the animal's daily activities such as eating and drinking. The device can be fabricated and maintained at low cost. | 2012-05-24 |
20120129117 | ORTHODONTIC TEETH POSITIONING APPLIANCES - An Orthodontic teeth positioning appliance comprising an anterior positioning component, a posterior component and a resilient means connecting the anterior and posterior components. The anterior positioning component is configured to be in contact with, in order to push against, the lingual faces of a plurality of anterior teeth, when worn by the user and the posterior component is configured to be anchored to at least one posterior tooth, when worn by the user in order that the resilient means urges apart the anterior positioning component from the posterior component. The appliance is preferably removable by the user. | 2012-05-24 |
20120129118 | Orthodontic Buccal Tube - Provided is an orthodontic buccal tube, which is capable of preventing glue from flowing out towards a boundary between a tooth ( | 2012-05-24 |
20120129119 | SELF-LIGATING ORTHODONTIC BRACKET HAVING UNDERCUTS AND RELATED METHODS - A method of manufacturing an orthodontic appliance may include molding a plurality of green bodies in plurality of molds and coupling the green bodies so as to form an intermediate green body. The orthodontic appliance may be an orthodontic bracket body. The plurality of green bodies may be molded so as to be devoid of any undercut formations. Coupling the plurality of green bodies may form the intermediate green body to include at least one undercut formation. An orthodontic bracket may include an undercut formation not capable of being formed in a single shot molding process and not formed through post-formation processes. The undercut formation may include a guiding track and/or a retaining recess configured to receive a portion of the ligating member. The ligating member may include a flexible ligating portion that overlies the archwire slot and a relatively rigid main body portion. | 2012-05-24 |
20120129120 | SET OF BRACKETS FOR ORTHODONTICS - The invention concerns a set of self-ligating brackets for orthodontics the brackets include a base, a block arranged on the base, an occlusal wall extending from the block and having at least one occlusal ligature wing, a gingival wall extending from the block and having at least one gingival ligature wing, a slot, which separates the occlusal wall and the gingival wall from one another, has the same minimum clear width for the brackets of the set and extends continuously in the direction from mesial to distal and has a base area on which an archwire lies during orthodontic treatment, and with a passage, which extends in the gingival-occlusal direction through the block and is delimited by a lingually located surface and by a labially located surface, as well as resilient clips with a labial leg and with a lingual leg, which are interconnected by an occlusally arranged portion. | 2012-05-24 |
20120129121 | Orthodontic Treatment Tube - Provided is an orthodontic treatment including a main tube, and a pair of caps provided at both ends of the main tube to form an adhesion space therebetween in which an adhesive is accommodated and the adhesive is prevented from flowing into the main tube through an insertion hole of the main tube. | 2012-05-24 |
20120129122 | Device for Orthodontic Arch and Brackets - Orthodontic device comprising an orthodontic arch or a wire and a set of brackets which have conduits through which said orthodontic arch passes characterized in that either of the following: a surface of the conduit of at least one bracket that is aimed to come into contact with the wire, or a region of the wire in contact with at least one bracket, has a textured surface with protruding regions and sunken regions for reducing the contact surface between the bracket and the orthodontic arch, the surface of the wire or of the bracket aimed to come into contact with the textured surface being of smooth nature. | 2012-05-24 |
20120129123 | MULTI-COORDINATE ORTHODONTIC IMPLANT POSITIONING DEVICE - A multi-coordinate orthodontic implant positioning device includes a measuring reference member having a predetermined thickness and being provided thereon with measuring scales formed of a radiopaque material. The measuring reference member is connected at an edge to a fixing member for fixedly attaching to the patient's teeth. The measuring scales define a coordinate-type positioning structure, which includes at least a main coordinate system and a sub-coordinate system. The main coordinate system divides the positioning structure into a plurality of coordinate blocks, each of which has a main coordinate code readable from the main coordinate system; and the sub-coordinate system is provided in some specified ones of the coordinate blocks. Since the main coordinate system and the sub-coordinate system are two different and independent coordinate systems, the use of them enables primary and more accurate positioning of an implant point to effectively upgrade the efficiency in the orthodontic implant surgery. | 2012-05-24 |
20120129124 | HANDPIECE HAVING AN ELECTRICAL CONNECTION MEANS - A dental handpiece ( | 2012-05-24 |
20120129125 | DENTAL MATRIX BAND - A dental matrix band device may be applied in a single step without the need for additional instruments for its application. The matrix band device may include a conventional matrix band, such as a Tofflemier™ band and a wire attached to the band. The band may be used to separate adjacent teeth, while the wire keeps the band in place until the procedure is completed. At the completion of the procedure, the band and wire are easily removed from the patient. | 2012-05-24 |
20120129126 | DEVICE AND PROCEDURE FOR IMPLANTING A DENTAL IMPLANT - Various tools and procedures are provided for implantation of an implant at a target site. The procedure can comprise performing an osteotomy at the target site; placing a guide sleeve into the osteotomy; inserting a coring tool into the guide sleeve; coring the target site up to a depth less than the depth of the osteotomy, the coring tool being configured to collect autogenous bone material from the target site during the coring of the target site; placing the implant at the implant site; and grafting the autogenous bone material into selected portions of the target site. | 2012-05-24 |
20120129127 | DEVICE FOR STORING AND DISPENSING A MATERIAL AND METHOD OF MAKING SUCH A DEVICE - A device for dispensing a dental material comprises a container for containing the material and an outlet which is closed by a closure. A breakable seal is arranged between the closure and the container. The device further is operable between a storage position in which the outlet is closed and an operational position in which the outlet is open. An initial operation toward the operational position causes the seal to break, whereby the closure is captured in the device. The device may provide a relatively long shelf life for the material, and may facilitate preparation of the material for use. | 2012-05-24 |
20120129128 | Vacuum Level Control Valve For A Dental Vacuum System - A control valve for a dental vacuum system includes a housing having a first end, a second end and a sidewall therebetween, which define a cavity of the housing. An imaginary central longitudinal axis extends from the first end to the second end and generally parallel to the sidewall. A first opening in the sidewall of the housing is operatively connected to a vacuum control volume and a pair of opposing second openings in the sidewall are spaced-apart from the first opening along the imaginary central longitudinal axis. A biasing member and a plunger valve are located within the cavity of the housing. The plunger valve is movable along the imaginary central longitudinal axis between a first position that blocks at least a portion of a flow of air through the housing and a second position that substantially permits the flow of air through the housing and to a vacuum pump. | 2012-05-24 |
20120129129 | MEDICAL CLEANING KIT - The present invention relates to the field of cleaning and/or conditioning of biological and dental implant surfaces. More particularly, the invention relates to a kit comprising a) a cleaning device said cleaning device ( | 2012-05-24 |
20120129130 | Torque wrench and kit for implant dentistry - A wrench for a installing a support member for a prosthesis including a body, rotating cylinder in the center, and cap. The cylinder has a cap on one end and a driver on the other. The bottom of the cap has radially disposed ridges and grooves. The body has bores therein, each with a spring and rotatable ball. Each ball protrudes from a bore and is in contact with a groove. | 2012-05-24 |
20120129131 | MEDICAL IMPLANT II - Medical implant at least partially consisting of a polymer, where:
| 2012-05-24 |
20120129132 | Expandable Bone Implant - An expendable bone implant has a first member with a coronal end portion configured for supporting a prosthesis. A second member is at least partially porous, engages the first member, and is configured to expand outwardly upon a longitudinal force being applied to at least one of the first and second members. This anchors the implant in bone before mastication forces are applied to the implant. | 2012-05-24 |
20120129133 | IMPLANT PELLETS AND METHODS FOR PERFORMING BONE AUGMENTATION AND PRESERVATION - Embodiments described herein are related to pellets that are placed within an extraction site that is in need of bone augmentation and preservation. The pellets are typically cylindrical in shape and comprise a material and a polymer coating. The goal of the pellets are to encourage sufficient new bone growth that jaw bone deterioration is prevented. The pellets create, arrange, and assemble an ideal growth environment for new bone growth to rapidly grow and preserve the original contours of an individual's jaw bone. | 2012-05-24 |
20120129134 | Light-Curable Bone Growth Material for Treating Dental Bone Defects - Improved compositions comprising a mixture of particulate bone growth material and polymeric carrier are provided. The particulate is preferably porous, resorbable, anorganic bone material. The polymeric carrier can be light-cured to form a cross-linked, biodegradable hydrogel. In one version, the bone growth material is a synthetic peptide bound to anorganic bone matrix particles and the carrier is methacrylated sodium hyaluronate (MHy) or methacrylated hydroxyethylcellulose (MHEC). The composition is particularly suitable for repairing defective dental and orthopedic bone tissue. The particulate and hydrogel carrier are biodegradable so the composition can be replaced by new bone formation over time. | 2012-05-24 |
20120129135 | NOVEL TYPE OF ANION-CONTAINING CALCIUM PHOSPHATE COMPOUND FOR DENTAL REMINERALIZATION - The invention provides an anion-containing calcium phosphate compound, composition and dental patch comprising the same and their use in remineralizing teeth. The anion-containing calcium phosphate compound has the following formula: | 2012-05-24 |
20120129136 | APPARATUS FOR CONVERTING A PISTOL INTO A WEAPON SIMULATOR - An apparatus for non-permanent conversion of a semiautomatic pistol into a compressed gas powered weapon simulator. The apparatus replaces the pistol's barrel, recoil spring and magazine with no modification of the pistol, which allows retaining the operational functions of the pistol's remaining components. Compressed gas, from the simulation magazine unit, is used in the compressed gas valve means, in the barrel unit, to operate the slide mechanism, to compress the simulation recoil spring, and to emit a laser pulse beam on a target when activated by the firing mechanism; and battery power, from the simulation magazine unit, is used to count the number of shots, lock the slide after a predetermined number of shots and transmit information from the weapon simulator to a remote data system. The compressed simulation recoil spring returns the slide mechanism back to its original position, unless locked open by the apparatus. | 2012-05-24 |
20120129137 | Video and Pictorial Mathematical Learning Kit and Method - A kit and method is described for introducing mathematical concepts to children through video tutorials and pictorial flash cards. The video tutorials include visual and auditory stimulation based on instructional and entertaining skits, cinematic representations and similar means to deliver and reinforce concepts. The flash cards correspond to the content of the videos tutorials, and are useful before, during and after the video tutorials for further reinforcement of the provided concepts. The kit and method utilize association and repetition as a basis to teach young children, and to provide physical meaning of basic mathematical concepts without requiring abstract thought or computational thinking therefrom. The kit may be tailored to a given audience by varying the chosen videos and flash cards based on a predefined lesson plan, allowing an instructor or parent to adjust the difficulty level to an appropriate level for a particular child or classroom of children. | 2012-05-24 |
20120129138 | DEVICE AND METHOD FOR EXERCISE PRESCRIPTION, DETECTION OF SUCCESSFUL PERFORMANCE, REPORTING, AND PROVISION OF REWARD THEREFORE - An exercise computer monitors the exercises of a user, especially a child, and provides rewards for exercises done well and regularly, thereby motivating the user. Rewards take the form of video games, cartoons, music, and merchant coupons. The exercise computer also provides encouragement and advice as the user progresses in skill level. Exercises may be prescribed. A record of exercise performance can be produced, to track the user's progress over time. The system and method can readily utilize the current install base of handheld computers and video games pre-existing in the marketplace. | 2012-05-24 |
20120129139 | DISEASE MANAGEMENT SYSTEM USING PERSONALIZED EDUCATION, PATIENT SUPPORT COMMUNITY AND TELEMONITORING - Disclosed herein are systems and methods for interactive guided personalized/personalizable patient disease management system. The system offers ongoing personalized education in response to user inputs which may include a patient's electronic health record, diagnostic codes, billing codes, and/or medical history, the ability to monitor a patient's progress throughout their treatment plan which is initially provided by the system and a patient support community for boosting patient treatment plan compliance through ongoing monitoring and personal coaching. The systems and methods provide personalized relevant diagnostic, prognostic, prevention and/or treatment information output which are curated to manage the patient's needs. | 2012-05-24 |
20120129140 | DENTAL MANIKIN - A dental simulator having a simulated teeth assembly, a manikin head and a locking mechanism. The manikin head is configured to receive the simulated teeth assembly. A locking mechanism includes a receiving portion and an interacting portion. The interacting portion is slidingly engaged with the receiving portion to thereby secure the simulated teeth assembly to the manikin head. Either the receiving portion or the interacting portion is connected to the simulated teeth assembly and the other of the receiving and interacting portion are connected to the manikin head. | 2012-05-24 |
20120129141 | e-Learning System - An e-Learning system provides a dashboard adapted to permit user navigation to a multiplicity of lessons. Each lesson is presented in a web page as an audio-video program and a text field adapted to permit a user to enter notes which watching the audio-video program is provided on the web page. Individual quizzes associated with each of the lessons are provided and once the individual quizzes have been completed the user may take a comprehensive final exam. Any notes taken during the lessons are accessible to the user during the quizzes and the final exam. | 2012-05-24 |
20120129142 | METHOD AND DEVICE FOR LEARNING IN ELECTRONIC BOOK READER - Provided is a method and device for learning in an electronic book reader. A method for learning in an electronic book reader includes displaying a mask region covering an object of electronic book contents displayed on a screen, and releasing the displayed mask region to again display the covered object of the electronic book contents. | 2012-05-24 |
20120129143 | System and method for generating a plot of a digital print - There is provided a system and method for generating a plot of a digital print. According to an exemplary embodiment, a method includes presenting a micro event of the digital print, the digital print having a plurality of micro events, each micro event having a plurality of outcomes and polling for user input for the micro event while presenting the micro event. The method further includes determining an outcome of the micro event based on the polling for user input and selecting a scenario from a scenario map based on the outcome of said micro event. Finally, the method includes generating a storyline of the plot based on the scenario selected from the scenario map. | 2012-05-24 |
20120129144 | Computer Aided Apparatus and Method of Learning - A learning device for students of all classes consisting of a virtual tutor. It comprises of hardware and software system with inbuilt internet. The tutor application is a software instructions executed in the central processing unit that reads the course contents stored in the hardware storage and gives the audio visual output to the learner. The device acts as an educational tool and provides assistance for assimilating the subject material. The device or system consists of inbuilt internet facility with internet browser and tracks user's activities. The user's activities get analyzed and user's profiling is generated for records and sent to parents. The device or system consists of search filter to prevent accessing of foul or irrelevant contents. Attachable Solar panels help operate the device when there is no electricity or in rural and remote regions where there is no electricity. | 2012-05-24 |
20120129145 | SYSTEM FOR FOSTERING INNOVATION AMONG A GROUP OF USERS - A computer-implemented system for facilitating users to develop, practice and apply competency in innovation-conducive behaviors and techniques. The system has a user system and coupled to the user system, a server system, a data store and an innovation enablement system (IES). IES has a first module that includes information to guide users through a first set of tasks directed to developing competencies in innovation. IES also has a second module that includes information to guide users through a second set of predetermined tasks, including at least two tasks that together form an innovation process that directs a user towards producing an innovation. IES also has a third module that integrates the first module and the second module, wherein information about the users, generated utilizing one of the two modules, can inform and facilitate what the users input as information when utilizing the other of the two modules. | 2012-05-24 |
20120129146 | ERASABLE WRITING PANEL INTEGRATED INTO ARTICLES - Various articles, such as notebooks, notepads, journals and folders, that include an integrated or integral erasable writing panel. The writing panel may be a cover member of the article, e.g., on a front surface thereof, and includes a substrate and a transparent or translucent sheet superposed relative to the substrate to overlie or be apart from the substrate. | 2012-05-24 |
20120129147 | METHOD OF PREPARING CONTROLS FOR GLYCATED HEMOGLOBIN S-A1C DERIVED FROM HEALTHY BLOOD CELLS - By way of summary, the present invention meets some or all of the above needs by providing in a first aspect a method comprising contacting red blood cells in a suspension medium containing mannose under conditions such that the concentration of S-Alc glycated hemoglobin is increased to greater than about 6 percent by weight of the hemoglobin in the red blood cells. Preferably the suspension medium is an aqueous suspension medium. In preferred embodiments, the method is performed at about ambient temperature, 18° C. to about 23° C. | 2012-05-24 |
20120129148 | COMPOSITIONS AND METHODS FOR THE STORAGE OF RED BLOOD CELLS - The present invention provides an aqueous composition for storage of red blood cells consisting essentially of: adenine; dextrose; at least one nonmetabolizable membrane-protectant sugar; and a specifically defined pH buffering system. Also provided are improved methods for preserving red blood cells and methods for increasing the viability, membrane retention, and recoverability while suppressing apoptosis, hemolysis, and post-reinfusion clearance of stored red blood cells which utilize the novel compositions. | 2012-05-24 |
20120129149 | REMOVAL OF OXYGEN FROM BIOLOGICAL FLUIDS - A system for reducing the concentration of oxygen in a fluid including red blood cells includes a housing, a plurality of hollow tubes extending within the housing and adapted for flow of the fluid therethrough, wherein each tube includes an inlet and an outlet, and a carrier system that reduces the concentration of oxygen at an exterior surface of the tubes to facilitate transport of oxygen from the fluid flowing through the tubes to an exterior of the tubes. | 2012-05-24 |
20120129150 | PARTICLES EMBEDDED IN A POROUS SUBSTRATE FOR REMOVING TARGET ANALYTE FROM A SAMPLE - The invention provides devices, test kits and methods for removing target agents from a sample. The device contains one or more porous matrices having pore sizes larger than | 2012-05-24 |
20120129151 | Quantitative Real-Time Assay For Noroviruses And Enteroviruses With Built In Quality Control Standard - A method is provided for reverse transcription-polymerase chain reaction (RT-PCR) accomplished by: a) amplifying a reverse transcribed cDNA in a mixture containing Norovirus Genogroup I and Norovirus Genogroup II primers and probes, in which the Norovirus primers and probes can distinguish between Genogroup I and Genogroup II viruses; b) quantifying virus; and c) normalizing data based on a universal internal RNA control. Optionally, the method may also include primers and probes for Enteroviruses. The present invention also provides a reaction mixture comprising containing Norovirus Genogroup I and Norovirus Genogroup II primers and probes, in which the Norovirus primers and probes can distinguish between Genogroup I and Genogroup II viruses and universal internal RNA control primers and probes. | 2012-05-24 |
20120129152 | Diagnostic method for the prediction of the development of and control over the effectiveness of treatment of cardiovascular illnesses - A diagnostic method for the prediction of the development and control of the effectiveness of the treatment of cardiovascular diseases, in which patient tissue samples are taken, microassay are prepared, specific antiviral immunoglobulins are processed, the number of cells infected by two or more viruses before the beginning of treatment are determined, and the dynamic of the change in the number of infected cells and their interrelationships are established: when the number of cells infected by cytomegalovirus and any other viruses decreases by more than 50±10% in patients without symptoms of cardiovascular pathology, a diagnostic conclusion is high danger of the development of atherosclerosis; if the number of cells infected by cytomegalovirus and any other viruses exceeds 50±10% in patients with demonstrated clinical signs of cardiovascular system pathology, a diagnostic conclusion is drawn of the danger of the development of complications such as arrhythmia, thrombolytic embolism. | 2012-05-24 |
20120129153 | Diagnostic method for the prediction of the development and control of the effectiveness of the treatment of oncological illnesses - A diagnostic method, in which patient tissue samples are taken, microassay are prepared, specific anti-viral immunoglobulins are processed, the number of cells infected by two or more viruses before the beginning of treatment are determined, and the dynamic of the change in the number of infected cells and their interrelationships are established: if the number of blood cells infected by any two or more viruses exceeds 50±10% in patients without signs of oncological pathology, a diagnostic conclusion is drawn of a high danger of oncological illness in connection with immune system ineffectiveness; if the number of cells infected by any two or more viruses exceeds 50±10% in patients with diagnosed oncological illnesses, a diagnostic conclusion of the cancer tumor's low sensitivity to chemotherapy and the perspective of quick tumor metastasis is drawn. | 2012-05-24 |
20120129154 | METHODS AND COMPOSITIONS FOR THE DETECTION OF BACTERIAL BLIGHT - Methods and compositions relating to the detection of bacterial blight are provided. In one embodiment, a detection system is provided comprising a phage operable to infect a | 2012-05-24 |
20120129155 | METHODS FOR AMPLIFYING HEPATITIS C VIRUS NUCLEIC ACIDS - A method of amplifying an HCV nucleic acid in an HCV infected sample comprises amplifying a segment of a DNA template that is complementary to a genome of HCV RNA from the sample by a two-stage PCR, wherein a first stage PCR employs a first outer primer and a second outer primer, and a second stage PCR employs a first inner primer and a second inner primer. The nucleotide sequence of the first outer primer comprises a nucleotide sequence as set forth in SEQ ID NO: 2; or SEQ ID NO:9, wherein optionally 1, 2 or 3 nucleotides are other nucleotides than those of SEQ ID NO: 9. The nucleotide sequence of the second outer primer comprises a nucleotide sequence set forth in SEQ ID NO: 3 or 4; or a nucleotide sequence as set forth in SEQ ID NO: 10 or 11, wherein optionally 1, 2 or 3 nucleotides are other nucleotides than those of SEQ ID NO: 10 and 11. The nucleotide sequence of the first inner primer comprises a nucleotide sequence as set forth in SEQ ID NO: 5; or SEQ ID NO:12, wherein optionally 1, 2 or 3 nucleotides are other nucleotides than those of SEQ ID NO: 12. The nucleotide sequence of the second inner primer comprises a nucleotide sequence as set forth in SEQ ID NO: 6 or 7; or a nucleotide sequence as set forth in SEQ ID NO: 13 or 14, wherein optionally 1, 2 or 3 nucleotides are other nucleotides than those of SEQ ID NO: 13 and 14. | 2012-05-24 |
20120129156 | BARRIERS FOR FACILITATING BIOLOGICAL REACTIONS - The present invention relates to systems, devices, and methods for performing biological reactions. In particular, the present invention relates to the use of lipophilic, water immiscible, or hydrophobic barriers in sample separation, purification, modification, and analysis processes. | 2012-05-24 |
20120129157 | Methods and Devices for Rapid Detection and Identification of Live Microorganisms by Aptamers and/or Antibodies Immobilized on Permeable Membranes - The invention provides methods, devices and kits for rapid detection and identification of one or more live target microorganisms in a liquid sample or grown on plates containing nutrient media. The invention includes mixing one or more target microorganisms with one or more aptamers and/or one or more antibodies, each conjugated to a reporter compound and specific for a first site on one or more target microorganisms to form a mixture. The mixture is placed on a permeable membrane having immobilized thereon one or more aptamers linked to an amine compound, and/or one or more antibodies, each specific for a second site on one or more target microorganisms or a site on the aptamer conjugate and/or antibody conjugate. A detection solution is added to the membrane and detection and identification of one or more target microorganisms is achieved in about one hour or less. | 2012-05-24 |
20120129158 | SYSTEMS AND METHODS FOR IDENTIFYING AND DISRUPTING CELLULAR ORGANELLES - This invention relates to optomechanical systems and methods for altering, modifying or disrupting a target object. Such systems and methods are used for, for example, ablating the endogenous nucleus in a cell. | 2012-05-24 |
20120129159 | METHODS AND COMPOSITIONS FOR PROTEIN LABELING USING LIPOIC ACID LIGASES - The present disclosure provides compositions and methods of use thereof for labeling peptide and proteins in vitro or in vivo. The methods described herein employ lipoic acid ligase or mutants thereof, and lipoic acid analogs (e.g., lipoic acid analogs comprising a resorufin moiety) recognized by lipoic acid ligase and lipoic acid ligase mutants. Also provided herein is a method of imaging protein-protein interaction via a reaction mediated by lipoic acid ligase. | 2012-05-24 |
20120129160 | RAPID IN VIVO GENE MUTATION ASSAY BASED ON THE PIG-A GENE - The invention relates to methods and kits for the quantitative analysis of in vivo mutation frequencies of the Pig-A gene in individuals, particularly using peripheral blood samples of vertebrates. | 2012-05-24 |
20120129161 | METHODS FOR MODULATING EMBRYONIC STEM CELL DIFFERENTIATION - Described herein is Zscan4, a gene exhibiting 2-cell embryonic stage and embryonic stem cell specific expression. Identification of nine Zscan4 co-expressed genes is also described. Inhibition of Zscan4 expression inhibits the 2-cell to 4-cell embryonic transition and prevents blastocyst implantation, expansion and outgrowth. Provided herein are methods of inhibiting differentiation of a stem cell, promoting blastocyst outgrowth of embryonic stem cells and identifying a subpopulation of stem cells expressing Zscan4. Further described is the identification of Trim43 as a gene exhibiting morula-specific expression. Also provided are isolated expression vectors comprising a Zscan4 promoter, or a Trim43 promoter operably linked to a heterologous polypeptide and uses thereof. Further provided are transgenic animals comprising transgenes encoding marker proteins operably linked to Zscan4 and Trim43 promoters. | 2012-05-24 |
20120129162 | CELL CULTURE SYSTEM FOR DETERMINING THE SENSITIZING, ALLERGENIC AND/OR IRRITATING EFFECT OF A SUBSTANCE - The present invention refers to a cell culture system especially for investigating the sensitizing, allergenic and/or irritating effect of substances, comprising a first and a second compartment that can communicate with each other via a permeable interlayer, whereby the first compartment has an epidermis model and the second a cell culture based on immune cells. | 2012-05-24 |
20120129163 | TESTING LUMENECTOMY SAMPLES FOR MARKERS OF NON-VASCULAR DISEASES - Lumenectomy material is tested to determine the presence or likelihood of a condition of a patient. The lumenectomy material is in the form of at least one continuous tissue strand collected in vivo from an inner surface of a body lumen of the patient. The presence of at least one marker of a disease is determined. The disease may be hypertension, hyperlipidemia, depression, obesity, metabolic syndrome, insulin resistance, kidney damage, or diabetes. The patient is identified as having or as likely to develop the disease if a marker of the disease is identified in the lumenectomy material of the patient. | 2012-05-24 |
20120129164 | DEVICE AND PROCESS FOR ISOLATING AND CULTIVATING LIVE CELLS ON A FILTER OR EXTRACTING THEIR GENETIC MATERIAL - The process for isolating live cells on a filter or extracting their genetic material. The process comprises the steps of attaching, at least temporarily, a filter to a lower opening of a compartment having, in addition, an air inlet; inserting into the compartment a liquid carrying the cells; and attaching, in an impermeable manner, a needle, at least temporarily, to the compartment opening, the filter being positioned between the needle and the interior volume of the compartment. The process further comprises the steps of perforation, with the needle, of a plug of a vacuum tube with negative pressure relative to ambient pressure; and aspiration, by means of negative pressure from the vacuum tube, of the liquid through the filter, the filter retaining the cells. | 2012-05-24 |
20120129165 | IMAGING INDIVIDUAL MRNA MOLECULES USING MULTIPLE SINGLY LABELED PROBES - A method for probing a target sequence of messenger ribonucleic acid molecules (mRNA's) in a fixed, permeabilized cell, said target sequence including at least 30 non-overlapping probe binding regions of 15-100 nucleotides, comprising immersing said cell in an excess of at least 30 nucleic acid hybridization probes, each singly labeled with the same fluorescent label and each containing a nucleic acid sequence that is complementary to a different probe binding region of said target sequence; washing said fixed cell to remove unbound probes; and detecting fluorescence from said probes. | 2012-05-24 |
20120129166 | METHOD OF DETECTING FUNGI BELONG TO GENUS GEOSMITHIA - A method of detecting a fungus belonging to genus | 2012-05-24 |
20120129167 | TRUNCATED CD20 PROTEIN, DELTACD20 - The present invention relates in particular to a protein from an alternative splicing of the gene encoding CD20, the nucleic acid sequences encoding the protein according to the invention, a mutated form of the CD20 gene as well as drugs, diagnostic tools, diagnostic methods and treatment methods using the protein and the nucleic acid sequences according to the invention. | 2012-05-24 |
20120129168 | TUMOR MARKER AND USE THEREOF - The present invention detects SNX5 in a sample from a subject. The SNX5 is used as a tumor marker specific to papillary thyroid carcinoma, whereby diagnosis of papillary thyroid carcinoma is carried out easily. The present invention provides also a technique of discriminating papillary thyroid carcinoma using the tumor marker. | 2012-05-24 |
20120129169 | Two-Step Cold Formalin fixation of organic tissue samples - A method for fixation of organic tissue samples includes immersing a tissue sample in a solution of Formalin at a temperature of between 2° C. and 10° C. for a first time period (A), and immersing the tissue sample in a cold fixation dehydrating agent for a second time period (B) following the first time period. An automated tissue fixation system for fixating organic tissue samples in Formalin is also described. | 2012-05-24 |
20120129170 | Methods for Identifying Genomic Deletions - The genomic locus responsible for Van Buchem's disease is narrowed to an approximately 92 kb region of human chromosome 17 at 17q21. Individuals afflicted with or carriers of Van Buchem's disease exhibit a 52 kb deletion within this 92 kb region. Methods are provided that permit the differentiation between individuals homozygous for and therefore afflicted with Van Buchem's disease, individuals heterozygous for and therefore carriers of Van Buchem's disease, and individuals who are normal with respect to Van Buchem's disease. Also provided are general methodologies for the detection of a wide variety of large genomic deletions. | 2012-05-24 |
20120129171 | Genetic Markers for Assessing Risk of Developing Bipolar Disorder - This document provides methods and materials related to genetic markers of Bipolar Disorder (BD) and Schizophrenia (SZ). For example, methods for using such genetic markers to assess risk of developing BD and/or SZ are provided, as are methods for making a differential diagnosis between BD and SZ. | 2012-05-24 |
20120129172 | METHOD FOR SELECTING CLONE OF INDUCED PLURIPOTENT STEM CELLS - To efficiently identify and select a clone from clones of induced pluripotent stem cells (iPS cell) having low tumor formation rate in vivo when allowed to differentiate and transplanted in a living body, iPS cells of the clones are induced to differentiate, undifferentiated cells among the cells after the induction of differentiation are detected, and a clone having the content of the undifferentiated cell below a control is selected. | 2012-05-24 |
20120129173 | RECOMBINASE POLYMERASE AMPLIFICATION REAGENTS AND KITS - This disclosure describes kits, reagents and methods for Recombinase Polymerase Amplification (RPA) of a target DNA that exploit the properties of re-combinase and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The disclosed kits, reagents and methods have the advantage of not requiring thermocycling or thermophilic enzymes, thus offering easy and affordable implementation and portability relative to other amplification methods. | 2012-05-24 |
20120129174 | Target Sequence Amplification Method, Polymorphism Detection Method, and Reagents for Use in the Methods - An object of the present invention is to provide an amplification method that inhibits amplification caused by erroneous annealing of a primer. Primers X1 and X2 are used in amplification of a target sequence including a target site showing a polymorphism. The primer X1 includes a sequence A1′ and a sequence E1. The sequence A1′ is complementary to a partial sequence A1 in a template nucleic acid, and has, in its 3′ region, a base x1′ complementary to a first base x1 at the target site in a 5′ region of the sequence A1. The sequence E1 is noncomplementary to a partial sequence B1 adjacent to the 3′ end of the partial sequence A1 in the template nucleic acid, and is bound to the 5′ end of the partial sequence A1′. The primer X2 includes a sequence A2′. The sequence A2′ is complementary to a partial sequence A2 in the template nucleic acid, and has, in its 3′ region, a base x2′ complementary to a second base x2 at the target site in a 5′ region of the partial sequence A2. Each of the primers X1 and X2 has a base complementary to the target site in its 3′ region. By these primers, when only a template in which the target site is the first base x1 is present, erroneous amplification of the target sequence having the second base x2 can be prevented. Thus, a false positive for the polymorphism of the second base x2 can be inhibited. | 2012-05-24 |
20120129175 | METHOD FOR RENAL DISEASE DIAGNOSIS AND PROGNOSIS USING ANNEXIN A1 AND RAB23 AS MARKERS - Use of Annexin A1 or Rab23 as a biomarker for diagnosing kidney disease or assessing efficacy of kidney disease treatment. | 2012-05-24 |
20120129176 | CYTOKINES AS PROGNOSTIC MARKERS OF RESPIRATORY-TRACT INFECTION FOLLOWING MAJOR SURGERY - The invention relates to the use of a certain subset of cytokine markers as prognostic variables of infection status in an individual, and especially as prognostic markers of a patients developing severe infection such as pneumonia, and respiratory tract infection following surgery. The subset of cytokine markers consists of the interleukin cytokines IL-2, IL-7, IL-23, IL-27, and IL-IO, and Interferon-γ (INFγ) and Tissue Necrosis Factor-α (TNFα). The markers may be employed as individual prognostic variables of infection status, or they may be used in pairs or other combinations. Generally, the abundance of the markers is correlated with infection status by means of an absolute pre-operative value of biomarker abundance, ratio's of pre-operative to post-operative biomarker abundance, or ratio values for pairs of certain biomarkers within the subset. Typically, cytokine abundance is expressed in terms of mRNA copy number wherein the copy numbers are ideally normalised to a house keeping gene and quantification of mRNA copy number is determined by RT-PCR containing reference serial dilutions of cytokine specific cDNA. | 2012-05-24 |
20120129178 | GENOMIC POLYMORPHISM FOR PREDICTING THERAPEUTIC RESPONSE - The present invention relates to the use of genomic polymorphism to provide individualized therapeutic regimens to treat patients suffering from diseases such as cancer. The invention discloses methods for determining the efficacy or choice of chemotherapeutic drugs and regimens for use in treating a diseased patient by associating genomic polymorphism with the effectiveness of the drugs or regimens, or by associating genomic polymorphism with the intratumoral expression of a gene whereby the gene expression affects effectiveness of the drugs or regimens. In particular, the present invention provides novel methods for screening therapeutic regimens, which comprise determining a patient's genotype at a tandemly repeated 28 base pair region in the thymidilate synthase (TS) gene's 5′ untranslated region (UTR). Patients homozygous for a triple repeat will be least successfully treated with a thymidylate synthase directed drug, while those heterozygous for a triple and a double repeat will be more successfully treated, and those homozygous for a double repeat will be even more successfully treated. Those patients homozygous for the double repeat will likely suffer the least side effects from thymidylate synthase directed drugs such as 5-FU. | 2012-05-24 |
20120129179 | SCN5A SPLICING FACTORS AND SPLICE VARIANTS FOR USE IN DIAGNOSTIC AND PROGNOSTIC METHODS - Provided herein are methods of identifying a subject at risk for arrhythmias, heart failure or sudden cardiac death. In exemplary aspects, the method comprises the step of determining a level of splicing factor hLuc7a, splicing factor RBM25 and/or PERK in a biological sample obtained from the subject, wherein an increased level, compared to a control level, indicates a risk for arrhythmia or heart failure. The invention also provides methods of diagnosing hypertrophic cardiomyopathy (HCM), or a risk therefor, in a subject. The method comprises the step of determining a level of E28D, RBM25, PRPF40A, or LUC7L3, or a combination thereof, in a biological sample obtained from the subject, wherein an increased level is indicative of the subject having HCM or a risk therefor. Diagnostic kits comprising binding agents for the markers are furthermore provided. | 2012-05-24 |
20120129180 | Method and A Kit for Detecting Antibiotic Resistant Bacteria - The present invention relates to a method and kit for detecting carbapenemase resistance genes causing carbapenem resistance in bacteria. The invention provides oligonucleotide primers, which can be used in the detection. The method can be used to detect OXA-48, SME, GIM-1, VIM 1-22, SPM, GES 1-10, KPC 1-7, IMI 1-3/NMC-A, IMP 1-24 within a single reaction and OXA-23 group, OXA-24 group, OXA-51 group with ISabal promoter, OXA-55, OXA-58, OXA-60, OXA-62, CMY 1, -10, -11 SFC-1, NDM-1, and SIM-1 within another single reaction. | 2012-05-24 |
20120129181 | DETECTION OF BACTERIAL (MOLLICUTES) CONTAMINATION - The present disclosure provides a method and system for the PCR amplification of a target sequence which suppresses non-specific amplification products. The disclosure concerns the use of a primer pair optimized to amplify a nucleic acid of a contaminant in the background of genomic DNA of a first organism. When DNA from a second organism suspected for comprising the contaminant is subjected to the same PCR-based amplification reaction, detection sensitivity and specificity of the contaminant is enhanced when an amount of genomic DNA of the first organism is present in the amplification reaction. | 2012-05-24 |
20120129182 | AMPLIFICATION OF COMPLEX NUCLEIC ACIDS - What is described is a method for quantitative and qualitative analysis of complex template nucleic acids to be analyzed. The method comprises the co-amplification of a control nucleic acid with the complex template nucleic acid by means of isothermal strand displacement reaction. The method of the invention further comprises the determination of the amount of amplified control nucleic acid as measure for the determination of the quantity and/or quality of the complex template nucleic acid used. The present invention also relates to a kit for carrying out a method of the invention. Furthermore, the use of the method of the invention or the kit of the invention for standardisation of whole-genome, whole-transcriptome and whole-bisulfitome analyses is described. | 2012-05-24 |
20120129183 | METHODS AND KITS FOR ISOLATING PLACENTAL DERIVED MICROPARTICLES AND USE OF SAME FOR DIAGNOSIS OF FETAL DISORDERS - A prenatal method of analyzing a fetus is disclosed. The method comprising: (a) isolating placental derived microparticles; and (b) analyzing at least one component of the contents of the placental derived microparticles, wherein the at least one component is indicative of a characteristic of the fetus. | 2012-05-24 |
20120129184 | SYSTEMIC CARNITINE DEFICIENCY GENE AND USES THEREOF - The gene responsible for systemic carnitine deficiency was found to be the OCTN2 gene involved in the transportation of organic cations. This invention enables tests for this disease by detecting whether or not the OCTN2 gene has a mutation. Furthermore, systemic carnitine deficiency can be treated using the normal OCTN2 gene and its protein. | 2012-05-24 |
20120129185 | METHODS AND COMPOSITIONS FOR DIAGNOSING ANKYLOSING SPONDYLITIS USING BIOMARKERS - The invention provides a method for determining the efficacy of a TNFα inhibitor, such as a TNFα antibody, or an antigen-binding portion thereof, for treating ankylosing spondylitis (AS), using a collagen degradation biomarker and/or a synovitis biomarker. | 2012-05-24 |
20120129186 | DEVICES AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF WOUNDS USING BIOMARKERS - The present invention provides for devices and methods for determining the healing phase of a wound. In some aspects, the present invention provides a wound diagnosis device comprising a surface and at least one agent that is specific to a desired biomarker. In another aspect, the present invention provides a method of determining the phase of wound healing. In still other aspects, the present invention provides methods of determining the phase of wound healing using the disclosed devices. | 2012-05-24 |
20120129187 | DIAGNOSTICAL USE OF PEROXIREDOXIN 4 - The present invention relates to a method for the diagnosis or prognosis of a disease or clinical condition in a subject comprising the steps of: (i) providing a sample of bodily fluid of a subject, (ii) determining the level of peroxiredoxin 4 (PRX4) or a fragment thereof having at least 20 amino acids residues in length in said sample, and (iii) correlating the level of PRX4 or a fragment thereof with a disease or clinical condition. | 2012-05-24 |
20120129188 | CIRCULATING CYTOCHROME C AS BIOMARKER OF REPERFUSION INJURY AND RESPONSIVENESS TO MITOCHONDRIAL TARGETED INTERVENTIONS - The present invention relates generally to the use of circulating cytochrome c as a biomarker of reperfusion injury that results from whole body ischemia. Circulating levels of cytochrome c can be used as predictor of survival rates and to assess the effects of interventions aimed at ameliorating mitochondrial injury during reperfusion. Whole body ischemia may be the result of cardiac arrest or from other hemodynamic crises, such as hemorrhagic shock. | 2012-05-24 |
20120129189 | Methods of Controlling Cell Proliferation - The present disclosure provides methods for increasing self-renewal/expansion of stem cells. The present disclosure provides methods of reducing uncontrolled cell proliferation. The present disclosure provides methods of identifying agents that modulate Notch1/-catenin binding, and methods of identifying agents that inhibit enzyme-mediated cleavage of Notch1 intracellular domain from Notch1 transmembrane domain. | 2012-05-24 |
20120129190 | ENSEMBLE-DECISION ALIQUOT RANKING - Provided herein, among other aspects, are methods and apparatuses for ranking aliquots from a suspension containing bioparticles. In certain embodiments, the bioparticles may be cells, organelles, proteins, DNAs, debris of biological origin, microbeads coated with biological compounds, or viral particles. As such, the methods and apparatuses provided herein may be used to quantify rare cells such as circulating cancer cells, fetal cells and other rare cells present in bodily fluids for disease diagnosis, prognosis, or treatment. | 2012-05-24 |
20120129191 | COCKTAIL ANTIBODY, DETERMINATION KIT AND DETERMINATION METHOD FOR DETERMINING HISTOLOGICAL TYPE OF CARCINOMA - The present invention provides a cocktail antibody useful for determining the histological type of cancer, and a determination method using the same cocktail antibody is disclosed. A determination kit is also provided. | 2012-05-24 |
20120129192 | Apparatus and Methods for Detection of Tumor Cells in Blood - In one embodiment, the present invention provides the description of an inexpensive and disposable handheld device for detecting Circulating tumor cells (CTC) in blood called a handheld CTC detector (HCTCD). The HCTCD is capable of detecting less than | 2012-05-24 |
20120129193 | DEVICE AND METHOD FOR ANALYSING CELLS - There is provided a carrier substrate for nonspecific immobilization of living bacterial and/or eukaryotic cells, especially of animal cells, which can be present as single cells, cell agglomerates or tissue sections. The surface of the carrier substrate is provided at least sectionally with a layer having or consisting of oligonucleic acids, preferably having ribonucleic acids covalently coupled to the carrier substrate, e.g. RNA, preferably single-stranded or double-stranded DNA. | 2012-05-24 |
20120129194 | Visible Detection of Microorganisms - Methods of detecting very low levels of targets, such as cells, are provided. In some embodiments, for example, the methods can detect bacteria present in a sample at concentrations less than 25 cells/mL. The method involves detecting nanoparticle aggregation in the absence of the target. | 2012-05-24 |
20120129195 | Method of quick laboratory diagnosis if illnesses based on the discovery of specific proteins and equipment for its implementation - A method of quick laboratory diagnosis of diseases, based on the discovery of specific protein targets characteristic to the disease in the reaction of their specific interaction with other protein reagents, distinct in that specific protein targets for the given disease are hydrolyzed with proteolytic enzymes and then the chemical structure of the oligopeptide formula created is modified in such a way that its charge is changed to the opposite. This method of quick laboratory diagnosis of illnesses based on the discovery of specific proteins, and the equipment for its implementation, may be applied for the discovery of viral and microbial antigens in various human biological fluids. The method may also be used for the detection of new and little-studied infectious diseases in connection with the ease of diagnostic preparation. | 2012-05-24 |
20120129196 | HIGHLY SENSITIVE MONOCLONAL ANTIBODY RESIDUAL DETECTION ASSAY - The present invention relates to compositions and highly sensitive methods for the detection of biotechnology product residual when monitoring product carry over and/or for cleaning verification in the manufacture of biotechnology products. In particular, the present invention is directed to immunoassays wherein one or more capture antibodies, or antigen binding fragments thereof, are used to detect residuals associated with the production of biotechnology products. | 2012-05-24 |
20120129197 | Immunomodulation of Functional T Cell Assays for Diagnosis of Infectious or Autoimmune Disorders - Improved assays for detecting the presence of a specific cell-mediated immune response in an individual are provided, where a sample comprising T cells and other cells of the immune system, usually a blood sample or derivative thereof, is contacted with test antigen(s) of interest in the presence of a pattern recognition receptor (PRR) agonist. The sample is incubated for a period of time sufficient to activate effector T cells; and release of immune effector molecule(s) is then detected. In some embodiments, the PRR is an agonist of a toll-like receptor (TLR) expressed by mature antigen presenting cells, including without limitation agonists TLR3 and TLR7, such as LPS, poly I:C, imiquimod, etc. | 2012-05-24 |
20120129198 | NOVEL METHODS FOR THE ASSAY OF TROPONIN I AND T AND COMPLEXES OF TROPONIN I AND T AND SELECTION OF ANTIBODIES FOR USE IN IMMUNOASSAYS - Assay systems and specialized antibodies for the detection and quantitation of troponin I and troponin T in body fluids as an indicator of myocardial infarction. Since troponin I and T exist in various conformations in the blood, the ratios of the monomeric troponin I an T and the binary and ternary complexes, as well as which form of troponin present in the blood, may be related to the metabolic state of the heart. Disclosed is a system to determine the presence of a troponin form or a group of troponin forms in a sample of whole blood, serum or plasma. | 2012-05-24 |
20120129199 | COMPOSITIONS, KITS AND METHODS FOR IN VITRO ANTIGEN PRESENTATION, ASSESSING VACCINE EFFICACY, AND ASSESSING IMMUNOTOXICITY OF BIOLOGICS AND DRUGS - Nanoparticle-based compositions, assays, kits, methods and platforms for delivering an antigen (peptides, proteins) or a nucleic acid encoding an antigen to professional APCs (PAPCs) result in the generation of autologous APCs that present a natural peptide repertoire of the antigen for use in assessing the efficacy of a vaccine (e.g., a cytotoxic T lymphocyte (CTL) response to a particular antigen) or other therapy or intervention (cell-based therapy, adjuvant therapy, etc.). The compositions, kits, assays and methods also can be used for delivering a drug or biologic or portion thereof to APCs for assessing the immunogenicity of drugs and biologics. The composition, kits, assays and methods involve the combined use of MHC targeting, universal DR binding peptides (e.g., PADRE, HA) with charged (e.g., positively-charged) highly branched polymeric dendrimers (e.g., PAMAM and other dendrimers) as vehicles for the targeted delivery of nucleic acids, peptides, biologics, drugs, or polypeptides to APCs, giving rise to a new nanoparticle-based method for assessing the immune response (CTL response) to a vaccination or other therapy or intervention, or for assessing the immunogenicity of a biologic or drug. Targeted delivery of nucleic acids, peptides, biologics, drugs, or polypeptides to APCs for effective expression and processing generates more physiologically relevant target antigens for evaluation of cell-mediated immune responses to vaccination, for example, and provides a low-cost approach for rapid generation of reagents and development of assay systems for more accurate profiling of immunological responses to infection, immunization, and other therapies or interventions. Immunoevaluation kits using targeted nanoparticle-based antigen delivery are described herein. | 2012-05-24 |
20120129200 | PRODEFENSIN-A6 ASSAY METHOD FOR THE IN VITRO DIAGNOSIS OF COLORECTAL CANCER - The present invention relates to a method for the in vitro diagnosis of colorectal cancer by determining the presence of the Prodefensin-A6 tumour marker in a biological sample taken from a patient suspected of having colorectal cancer, it being possible for said method to be used both in early diagnosis, screening, therapeutic follow-up and prognosis, and in relapse diagnosis in relation to colorectal cancer. | 2012-05-24 |
20120129201 | MASS SPECTROMETRY IMAGING WITH SUBSTANCE IDENTIFICATION - A method for the identification and localization of proteins or other biomolecules of a histologic tissue section comprises enzymatically digesting the biomolecules of two similar tissue sections while substantially preserving the biomolecule positions in the tissue sections. Next, a mass spectrometric image of the digest products in one of the tissue sections is acquired. Then, the digest products of the other tissue section are extracted and separated and the mass spectra and daughter ion spectra of all the digest products are acquired. A list of all identifiable biomolecules of the tissue section is created by comparing the mass spectra and daughter ion spectra with spectra in biomolecule structure databases or spectral libraries. Finally, the biomolecules in the list are assigned to digest products of the same mass in the mass spectra used to create the mass spectrometric image of the thin tissue section. | 2012-05-24 |
20120129202 | COMPOSITION FOR ASSAYING GLYCATED PROTEINS - Compositions for accurately assaying a glycated protein by: 1) avoiding effects of globulin and ascorbic acid components, 2) stabilizing proteases and at least enzymes acting on glycated amino acids; 3) accurately assaying albumin; and 4) assaying glycated albumin while avoiding the effects of glycated hemoglobin, and an assay method are provided. Thus, the contents of a glycated protein and glycated albumin can be more accurately determined. | 2012-05-24 |
20120129203 | Novel Peptidase Substrates - The present invention relates to the use of a compound of the following formula (I) for detecting a peptidase activity and/or a variation in pH: | 2012-05-24 |
20120129204 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES - The invention relates to the use of a compound having formula (I) as an enzymatic substrate for the detection of a nitroreductase activity, wherein: W | 2012-05-24 |
20120129205 | Novel Nitroreductase Enzymatic Substrates - The invention relates to the use of a compound having formula (I) as an enzymatic substrate for the detection of a nitroreductase activity or as an enzymatic substrate for the detection of a nitroreductase activity and indicator of pH, wherein:
| 2012-05-24 |
20120129206 | METHOD OF IDENTIFYING PATIENTS SUITABLE FOR HIGH-DOSE CYCLOPHOSPHAMIDE TREATMENT - The present invention provides methods of identifying subjects that are suitable for high-dose cyclophosphamide treatment. | 2012-05-24 |
20120129207 | COMPOSITIONS AND METHODS OF FUNCTIONALLY ENHANCED IN VITRO CELL CULTURE SYSTEM - Compositions and methods described herein provide a cell culture system in which cells are in high metabolic states from the onset of the culture. Combinations of various cell culture components disclosed and employed herein allow cells to be in high metabolic states useful for drug testing immediately after the start of cell culture. | 2012-05-24 |
20120129208 | HONEYCOMB SHRINK WELLS FOR STEM CELL CULTURE - This invention provides a microwell array having a plurality of microwells on a hydrophobic surface wherein the microwells each is substantially proximate to each of its adjacent microwells, as well as methods to prepare arrays. Also provided is a plate that comprises at least one microarray, at least one input channel, at least one output channel, and a channel connecting the input and output channel. | 2012-05-24 |
20120129209 | ALIGNING CELLS ON WRINKLED SURFACE - A method is provided for preparing an aligned cell population comprising the culturing one or more cells on a surface having a texture, which texture has an average height of from about 100 nanometers to about 5 micrometers, thereby forming an aligned cell population on the textured surface. Also provided is a method to prepare the surface which method comprises the steps of: a) depositing a metal onto an unstressed or pre-stressed thermoplastic material; b) reducing the surface area of the receptive material by at least about 60%; and c) preparing the surface via lithography. | 2012-05-24 |
20120129210 | Method for Assaying Inositol Hexaphosphate (IHP) - The invention relates to a method for assaying inositol hexaphosphate (IHP) in a product that can be injected in humans or animals or in a fraction of this product, in which a metal compound is added to a sample or a fraction of this product and the complexation of said metal compound with the IHP present is subsequently detected, by virtue of which the IHP present in the product or fraction thereof is assayed. The invention makes it possible to assay the IHP in a suspension or a solution, and in particular in the various compartments of a suspension of red blood cells. | 2012-05-24 |
20120129211 | TITRATION OF DIFFERENTIATION MEDIUM COMPONENTS - Methods and composition for differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including screening of optimal differentiation conditions for a selected stem cell clone in a selected batch of culture medium and use of the determined optimal condition for differentiation into a specific cell lineage. | 2012-05-24 |
20120129212 | METHOD OF MONITORING ERYTHROPOIESIS - The invention relates to methods of monitoring erythropoiesis. In particular, the invention relates to methods of detecting nascent erythrocyte production in vivo as methods for identifying modulators of erythropoiesis. | 2012-05-24 |