20th week of 2017 patent applcation highlights part 37 |
Patent application number | Title | Published |
20170138886 | Analyte Sensors and Methods of Using Same - Provided are sensors for determining the concentration of an analyte in a sample fluid. In certain embodiments, the sensors include conductive particles and exhibit improved uniformity of distribution of one or more sensing chemistry components, increased effective working electrode surface area, and/or reduced entry of interfering components into a sample chamber of the sensor. Methods of using and manufacturing the sensors are also provided. | 2017-05-18 |
20170138887 | Analyte Test Sensor And Method Of Manufacturing The Same - An analyte test sensor for use in measuring the concentration of a particular analyte in a test sample includes a non-conductive substrate, a reference electrode deposited on the substrate, a working electrode deposited on the substrate and a compensation electrode deposited on the substrate. The compensation electrode is provided with a resistive ladder and is designed to correct for test result inaccuracies which are the result of variances in the manufacturing of the test sensor. Specifically, in one embodiment, the compensation electrode corrects for test result inaccuracies in an analog manner by shunting a portion of the working current away from working electrode. In another embodiment, the compensation electrode corrects for test result inaccuracies in a digital manner by providing a calibration code which is proportional its resistance value. A batch of analyte test sensors are preferably manufactured in the following manner. An initial batch of the test sensors is constructed. Then, a limited sampling of the sensors is tested for accuracy using a control sample. Based on the test results, the resistance value of the compensation electrode for each remaining sensor in the batch is adjusted accordingly. | 2017-05-18 |
20170138888 | APPARATUS AND METHOD FOR MEASURING ERYTHROCYTE SEDIMENTATION RATE - An apparatus and method for measuring an erythrocyte sedimentation rate based on a change in conductivity of blood over time. The apparatus for measuring an erythrocyte sedimentation rate may include: a chamber for holding blood; a pair of electrodes being partially or completely brought into contact with the blood; and a conductivity meter measuring the conductivity through the pair of electrodes. The apparatus and method according to the present invention are less time-consuming than the Westergren method and can acquire a variety of information (for example, hematocrit, dynamics of the sedimentation rate and aggregation of erythrocytes, a relationship between the sedimentation rate and aggregation of erythrocytes, and the like). | 2017-05-18 |
20170138889 | BIOLOGICAL TEST SHEET - A biological test sheet includes an insulating substrate, an electrode structure, a first insulating septum and an insulating layer. The electrode structure is disposed on the insulating substrate and has at least one top surface and at least one side surface, and the side surface is connected between at least one fringe of the top surface and the insulating substrate. The first insulating septum is disposed on the insulating substrate and partially covers the electrode structure. The first insulating septum has a notch, and the notch exposes a first segment of the electrode structure. The insulating layer covers the fringe of the top surface and the side surface at the first segment of the electrode structure. | 2017-05-18 |
20170138890 | GAS SENSOR CONTROL METHOD - A catalytic conversion characteristic of a catalyst, which indicates a relationship between an air-to-fuel ratio and a catalytic conversion efficiency of the catalyst, includes a second air-to-fuel ratio point, which is a point of starting an outflow of NOx from the catalyst and is located on a rich side of a first air-to-fuel ratio point that forms an equilibrium point for a rich component and oxygen. A constant current circuit, which induces a flow of an electric current from an exhaust side electrode to an atmosphere side electrode through a solid electrolyte layer in a sensor element, is connected to the sensor element. A microcomputer controls a current value of the electric current, which is induced by the constant current circuit, based on a difference between the first air-to-fuel ratio point and the second air-to-fuel ratio point at the catalyst. | 2017-05-18 |
20170138891 | GAS SENSOR, METHOD FOR PRODUCING CONDUCTIVE PASTE, AND METHOD FOR MANUFACTURING GAS SENSOR - A gas sensor capable of measuring a high concentration range is provided. A sensing electrode provided in a sensor element of a mixed-potential gas sensor for measuring the concentration of a predetermined component in a measurement gas is formed of a cermet including a noble metal and an oxygen-ion conductive solid electrolyte. The noble metal includes Pt and Au. A Au abundance ratio, which is an area ratio of a portion covered with Au to a portion at which Pt is exposed in a surface of noble metal particles forming the sensing electrode, is 0.1 or more and less than 0.3. | 2017-05-18 |
20170138892 | A/F SENSOR ELEMENT AND METHOD OF MANUFACTURING THE SAME - An A/F sensor element includes a substrate made of an insulating ceramic having a bottomed cylindrical shape, an electrolyte part made of a solid electrolyte, and a pair of electrode portions. The electrolyte part is embedded in at least a portion of the side wall of the substrate. The A/F sensor element is used by inserting a rod-like heater in the substrate having the bottomed cylindrical shape. The substrate is formed of the insulating ceramic at a contact position to the heater within the substrate. In a manufacturing of the substrate, a molded body having a space for a forming position of the electrolyte part is formed by using substrate-forming clay, and then the molded body is molded by filling electrolyte-forming clay into the space. | 2017-05-18 |
20170138893 | GAS SENSOR AND METHOD FOR MANUFACTURING GAS SENSOR - A gas sensor with excellent detection sensitivity is provided. A sensing electrode, which is provided in a mixed-potential gas sensor for measuring a concentration of a predetermined gas component of a measurement gas to sense the predetermined gas component, is formed of a cermet of a noble metal and an oxygen-ion conductive solid electrolyte. The noble metal includes Pt and Au. A range of at least 1.5 nm from a surface of a noble metal particle included in the sensing electrode is a Au enriched region having a Au concentration of 10% or more. | 2017-05-18 |
20170138894 | GAS SENSOR - A mixed-potential gas sensor for measuring a concentration of a predetermined gas component of a measurement gas includes sensing electrodes mainly made of an oxygen-ion conductive solid electrolyte and located on a surface of a sensor element, and at least one reference electrode including a cermet including Pt and an oxygen-ion conductive solid electrolyte. The sensing electrodes each include a cermet including a noble metal and an oxygen-ion conductive solid electrolyte. The noble metal includes Pt and Au. A Au abundance ratio, which is an area ratio of a portion covered with the Au to a portion at which the Pt is exposed in a surface of noble metal particles forming each of the sensing electrodes, differs among the sensing electrodes. The gas sensor determines a concentration of the predetermined gas component based on a potential difference between each of the sensing electrodes and the at least one reference electrode. | 2017-05-18 |
20170138895 | GAS SENSOR - A gas sensor includes a sensor element having a detection section at a distal end portion thereof, and an element cover that surrounds a periphery of the sensor element. The sensor element includes electrodes and formed on a surface of a solid electrolyte body, a heater, and a porous protective layer formed on an outside of the detection section. The element cover includes a cover member with gas flow holes on a side surface and a gas passage is formed between the cover member and the sensor element. A distance between the cover member and the side surface of the sensor element in a direction perpendicular to an axis of the sensor element is in a range of 0.2 mm to 0.8 mm in the entire region of the gas passage leading from the gas flow holes to the detecting section. | 2017-05-18 |
20170138896 | GAS SENSOR INCLUDING SENSOR ELEMENT, HOUSING AND ELEMENT COVER - A gas sensor is provided with: a sensor element having a solid electrolyte body, a measurement electrode and a reference electrode; a housing into which the sensor element is inserted; and an element cover arranged at the tip-end side of the housing. The element cover has an inner cover arranged so as to cover the tip-end portion of the sensor element from outside, and an outer cover arranged so as to cover the inner cover from outside. When L is defined as an axial distance from a base end of an internal space of the inner cover to the base end of the measurement electrode, an axial distance M from the base end of the internal space of the inner cover to the base end of an inner vent hole positioned in the most base-end side among the inner vent holes provided to the inner cover is 0.2 L to 0.65 L. | 2017-05-18 |
20170138897 | ELECTROPHORESIS CONTROLLERS, SENSORS, AND METHODS FOR CONTROLLING ELECTROPHORESIS PROCESSES - An electrophoresis controller for use with an electrophoresis apparatus having a gel matrix disposed between electrodes for separation of particles along with a tracking dye. The electrophoresis controller includes a sensor system and a controller. The sensor system includes a support, a light emitter, and a light receiver. The support includes a first portion positionable on a first side of the gel matrix and a second portion positionable adjacent a second side of the gel matrix. The light emitter is positioned on the first portion of the support for emitting light onto one side of the gel matrix. The light receiver is positioned on the second portion of the support adjacent to the other side of the gel matrix for receiving light from the light source as it is passing through the gel matrix. At least one of the light emitter and the light receiver includes a light guide having a first end and a second end. The first end is positioned on the support and facing the gel matrix, and the second end is remote from the sensor system. The controller is operably connected to the sensor for monitoring a change in the light from the illuminated gel matrix due to migration of the tracking dye into the illuminated gel matrix and received by the light receiver. | 2017-05-18 |
20170138898 | NANOPORE-BASED DETERMINATION OF PROTEIN CHARGE, SHAPE, VOLUME, ROTATIONAL DIFFUSION COEFFICIENT, AND DIPOLE MOMENT - Physical parameters of macromolecules are determined by measuring electrical current I over time for translocation events as the macromolecules in solution move between two liquid compartments that are separated by and fluidically coupled through a synthetic nanopore. Values of charge, volume, shape, rotational diffusion coefficient, ad dipole moment are derived from the measurements. | 2017-05-18 |
20170138899 | Hole Formation Method and Measurement Device - While an insulating film having a near-field light generating element placed thereon is being irradiated with light in an electrolytic solution, or after the film that has been irradiated with light is disposed in the electrolytic solution, a first voltage is applied between the two electrodes installed in the electrolytic solution across the film, a second voltage is then applied between the two electrodes, and a value of a current that flows between the two electrodes due to the application of the second voltage is detected. This procedure is stopped when the current value reaches or exceeds a pre-set threshold value, whereby a hole is formed at a desired location in the thin-film. | 2017-05-18 |
20170138900 | ELECTROCHEMICALLY ACTUATABLE ELECTRONIC COMPONENT AND PROCESS FOR PRODUCING THE ACTUATABLE ELECTRONIC COMPONENT - An electrochemically actuatable electronic component comprises: a substrate; at least one first and one second actuating electrodes; at least one first and one second measuring electrodes; at least one storing electrode configured to free ions under the action of the actuating electrodes; at least one ionic conductor able to conduct the ions and that is located in a region placed between the measuring electrodes; a device suitable for: applying a voltage or a current between the first and second actuating electrodes to allow the migration of ions from the storing electrode to the first actuating electrode forming thereon an electrochemical deposition through the ionic conductor and for measuring, between the first and second measuring electrodes, a modification of at least one characteristic of the region placed between the first and second measuring electrodes, to determine at least one characteristic of the electronic component. | 2017-05-18 |
20170138901 | ELECTRODE DRIVE AND SENSING CIRCUITS AND METHODS - An electrode drive and sensing circuit and method are provided for a fluidics droplet actuator apparatus. The circuit comprises a droplet operations electrode. An electrowetting (EW) driver is connected to the droplet operations electrode by a signal path. The EW driver is to supply an electrowetting drive signal component to the droplet operations electrode. A capacitance measurement (CM) device is connected to the droplet operations electrode by the signal path. The CM device is to sense a sensing signal component indicative of at least one of a presence or absence of a droplet at the droplet operations electrode. A first coupling circuit is positioned between the EW driver and the droplet operations electrode along the signal path. A second coupling circuit is positioned between the CM device and the same droplet operations electrode along the signal path. | 2017-05-18 |
20170138902 | DARKROOM TYPE SECURITY INSPECTION APPARATUS AND METHOD - The present invention discloses darkroom type security inspection apparatus and method. An apparatus comprises a housing constituting a closed darkroom, and assemblies disposed inside the housing. The assemblies disposed inside the housing are communicated by fittings or connectors and comprises: a sampling assembly comprising a sample collecting unit and a conveyer unit configured to convey an object to be inspected into the sample collecting unit; a sample processing assembly configured to concentrate and analyze the sample; and, an inspecting assembly configured to inspect composition of the sample by means of a gas chromatographic-ion mobility spectrometer (GC-IMS) or a separated ion mobility spectrometer (IMS). The security inspection apparatus of the present invention can perform the sampling easy, rapidly and effectively and perform the inspection accurately and rapidly without destroying and unpacking an object to be inspected, and thus is suitable for requirements of on-site rapid inspection of forbidden items in the airport, customs and the likes. | 2017-05-18 |
20170138903 | SHUTTER FOR AN ION MOBILITY SPECTROMETER - The invention relates to a shutter for an ion mobility spectrometer ( | 2017-05-18 |
20170138904 | ION MOBILITY SEPARATION DEVICE - A drift voltage generator under the control of the control unit applies a rectangular waveform voltage to each annular electrode so as to form alternately in times a uniform accelerating electric field for accelerating the ions introduced to the drift region toward the end of the drift tube and a uniform decelerating electric field for decelerating the ions. The control unit adjusts the duty ratio of the rectangular waveform voltage according to the preset degree of separation. By forming a decelerating electric field periodically, the average movement speed of ions becomes slow compared to the case of forming an accelerating electric field continuously. Thereby, the drift time becomes longer despite of the same drift distance, enlarging the difference of time for the two types of ions having different mobility to arrive at the detector, improving the degree of separation. | 2017-05-18 |
20170138905 | CASING DEFECT DETERMINATION USING EDDY CURRENT TECHNIQUES - A system comprises one or more electromagnetic coils configured to generate and direct excitation signals toward a plurality of casings in a wellbore and receive response signals based on the excitation signals. The system further comprises one or more processors configured to receive a first response signal from the one or more electromagnetic coils and determine one or more characteristics of a first defect in the plurality of casings using the first response signal and small defect information. | 2017-05-18 |
20170138906 | SYSTEM AND METHOD FOR INSPECTING PARTS USING FREQUENCY RESPONSE FUNCTION - A system and method for the non-destructive testing of additively manufactured parts. An input mechanism excites with an excitation force (e.g., a vibration) an additive manufacturing build platform on which the part is located to induce a dynamic response in the part. An output mechanism (e.g., a non-contact transducer) senses the induced dynamic response in the part. A processor determines and examines the relationship between the response and excitation to identify an indication of a defect in the part, and communicates an alert if the indication is identified. The processor may compare the phase, magnitude, coherence, or time delay of the relationship to a reference relationship and/or may compare the modal frequency or the modal damping to a reference to identify a deviation greater than a pre-established threshold. | 2017-05-18 |
20170138907 | Ultrasonic System for Nondestructive Testing - Example systems and methods for nondestructive ultrasonic testing are provided. One example system includes at least one air-coupled ultrasonic transducer configured to emit primary ultrasound waves that interfere with each other. The primary ultrasound waves include fundamental frequency components that are multiples of each other and emitted simultaneously in locked phase. Further, the interference of the primary ultrasound waves generates a plurality of frequency harmonics in the air. The system also includes at least one receiver configured to receive ultrasonic waves emitted from an object under test. | 2017-05-18 |
20170138908 | ANCHOR BOLT DIAGNOSING SYSTEM, METHOD OF THE SAME, AND PROGRAM OF THE SAME - An anchor bolt diagnosing system includes a vibration sensing clip that clips an anchor bolt, and senses a vibration power of the anchor bolt, a blow sensing hammer that gives a blow to the anchor bolt clipped by the vibration sensing clip, and senses blow strength, and a diagnoser that obtains the vibration power and the blow strength output from the vibration sensing clip and the blow sensing hammer, and diagnoses soundness of the anchor bolt in accordance with whether a ratio of the vibration power to the blow strength is higher than a predetermined value. | 2017-05-18 |
20170138909 | METHODS, SYSTEMS, AND FIXTURES FOR INSPECTION OF GASKET WELDS - A method may involve positioning a fixture over a portion of a tube portion of a gasket, where the gasket includes a first lip portion joined to a second lip portion by a weld of the gasket and the first lip portion joined to the second lip portion defines the tube portion, where the fixture comprises a housing and an injection port; positioning an ultrasonic probe in the housing; filling, by the injection port, coupling fluid between the ultrasonic probe and the tube portion of the gasket; and scanning at least a portion of the weld with the ultrasonic probe, where scanning the at least a portion of the weld may involve transmitting, by the ultrasonic probe, a plurality of ultrasonic waves through the coupling fluid into the tube portion, and translating the fixture in a longitudinal direction along the tube portion of the gasket. | 2017-05-18 |
20170138910 | DETECTION DEVICE, DETECTION SYSTEM, AND DETECTION METHOD - According to one embodiment, a detection device is provided in a structure. The structure is constituted of: a first member; a second member provided on an opposite side of the first member; and a welded portion that is provided along an end of the second member facing the first member and fixes the first member and the second member. The detection device include: a plurality of acoustic emission sensors that are disposed so as to be separated from each other in a direction in which the welded portion extends and are configured to detect an elastic wave transmitted to the second member, each acoustic emission sensor being attached to the second member; and an outputter that outputs information, obtained from outputs of the plurality of the acoustic emission sensors, to an outside. | 2017-05-18 |
20170138911 | Acoustic Measurement of Fabrication Equipment Clearance - A system and method for determining clearance between a fabrication tool and a workpiece is provided. In an exemplary embodiment, the method includes receiving a substrate within a tool such that a gap is defined there between. A transducer disposed on a bottom surface of the substrate opposite the gap provides an acoustic signal that is conducted through the substrate. The transducer also receives a first echo from a top surface of the substrate that defines the gap and a second echo from a bottom surface of the tool that further defines the gap. A width of the gap is measured based on the first echo and the second echo. In some embodiments, the bottom surface of the tool is a bottom surface of a nozzle, and the nozzle provides a liquid or a gas in the gap while the transducer is receiving the first and second echoes. | 2017-05-18 |
20170138912 | Gas chromatograph and methods for using air as a carrier gas - The disclosure describes embodiments of an apparatus useful for the on-line analysis of gas and liquid samples including a gas compressor or pump, a sampling valve, a separation module, and one or more detectors. The detectors may include catalytic pellistors, thermal conductivity devices, or other sensors capable of detecting chemical substances in the presence of ambient air. These particular sensors in combination with reference elements allow direct use of ambient air as the carrier for analysis without pretreatment of the said air. Other embodiments are disclosed and claimed. | 2017-05-18 |
20170138913 | SEALING MOVING WITH PISTON IN A HIGH-PRESSURE PUMP - A piston member for a high-pressure pump for pumping fluid in a sample separation apparatus, wherein the piston member comprises a piston configured for being mountable to reciprocate in a piston chamber for displacing fluid, and a sealing for sealing between the piston member and the piston chamber when the piston member is mounted in the piston chamber to reciprocate, wherein the sealing is mounted on the piston so as to reciprocate together with the piston. | 2017-05-18 |
20170138914 | DARKROOM TYPE SECURITY INSPECTION APPARATUS AND METHOD - A darkroom type security inspection apparatus and a method of performing an inspection using the darkroom type security inspection apparatus. An apparatus includes a housing constituting a closed darkroom, and assemblies disposed inside the housing. The assemblies disposed inside the housing include: a sample collecting unit configured to collect a sample, a conveyor unit, and a X-ray detection unit to detect a position of the objected to be inspected, wherein the X-ray detection unit is configured to determine the position of the objected to be inspected within the sampling assembly so that the object to be inspected together with the conveyor unit is conveyed to an expected position; and a sample processing assembly, wherein the assemblies disposed inside the housing are communicated by fittings or connectors. | 2017-05-18 |
20170138915 | Staggered Chromatography Mass Spectrometry - An analytical instrument is disclosed comprising a liquid chromatography system comprising a first column, a chromatographic delay line and a splitter arranged and adapted in a mode of operation to split eluent from the first column into a first portion of eluent and a second portion of eluent. The instrument further comprises a first device. The liquid chromatography system is arranged and adapted in the mode of operation: (i) to pass the first portion of eluent from the splitter to the first device such that a first part of the first portion of eluent arrives at the first device at a first time ti and a second part of the first portion of eluent arrives at the first device at a second time t | 2017-05-18 |
20170138916 | CHROMATOGRAPH MASS SPECTROMETER AND PROGRAM - A chromatograph mass spectrometer has a function that: based on a compound table in which an elution time range and a measurement ion is described for respective compounds, divides an overall measurement time into multiple segments and assigns one or more compounds to each segment; determines an event time for each compound by dividing a previously given measurement loop time in accordance with a number of compounds belonging to the respective segments; and determines a dwell time, which is a data collection time for each ion, based on the event time and the number of ions to be measured for each compound; the chromatograph mass spectrometer allowing an analysis operator to designate whether or not to perform a high-sensitivity analysis for each compound. | 2017-05-18 |
20170138917 | TITRATION METHOD USING A TRACER TO QUANTIFY THE TITRANT - A titration method uses a tracer in the titrant or titrand to quantify the amount of titrant added. The method does not require quantitative addition of titrant or sample. The tracer can be inert or can participate as an indicator of the titrant-analyte reaction. The tracer concentration is quantified by an appropriate method depending upon the type of tracer and analytical performance desired (e.g. precision, accuracy). The method simplifies titrations because it eliminates the need for a precision dispensing device and analytical balance. | 2017-05-18 |
20170138918 | GAS DETECTION SYSTEM FOR TOXIC AND/OR FLAMMABLE GAS - The present invention relates to the field of detection of combustible, flammable and toxic gases present in the air, particularly any way generated by pipe leaks, such as leaks of gaseous hydrocarbons or evaporation or similar potentially toxic and/or explosive gases. For example a sector object of the present invention is the gas environmental detection, more particularly for safety and protection of operators in gas drilling, extraction, transport and stocking. The present invention described a system of detection of flammable and/or toxic gases, comprising detection elements able to increase the reliability of detection of said elements dangerous for both human beings and the environment. | 2017-05-18 |
20170138919 | RAMAN SPECTROSCOPIC DETECTION DEVICE - A Raman spectroscopic detection device comprising at least one microfluidic sample channel; at least one excitation waveguide for exciting a Raman signal and at least one collection waveguide for collecting a Raman signal. The output of the excitation waveguide and the input of the collection waveguide are positioned directly in the microfluidic sample channel | 2017-05-18 |
20170138920 | Methods of separation of a metal from its liquid-soluble oxide for analysis - Various methods for separating a metal from its metal oxide for analysis are provided. For example, exemplary methods include approaches for providing a process for separating a metal from its water-soluble metal oxide in a pyrotechnic composition. Exemplary embodiments include a method of separation that allows for analysis of both metal and metal oxide using an elemental analysis technique, (e.g., inductively coupled plasma optical emission spectrometry (ICP-OES)) and determination of the relative amount of elemental metal and its oxide known as speciation. | 2017-05-18 |
20170138921 | Determining Properties of OBM Filtrates - Methods and apparatus for operating a downhole tool within a wellbore adjacent a subterranean formation to pump contaminated fluid from the formation into the downhole tool while measuring first and second fluid properties of the contaminated fluid. The contaminated fluid comprises native fluid from the formation and a contaminant. The downhole tool is in communication with surface equipment located at surface. The downhole tool and/or surface equipment is operated to estimate a formation volume factor of the contaminated fluid based on at least one of the first and second fluid properties of the contaminated fluid. A linear relationship is then estimated between the first fluid property and a function that relates the first fluid property to the second fluid property and the estimated formation volume factor of the contaminated fluid. A fluid property of the contaminant is then estimated based on the estimated linear relationship. | 2017-05-18 |
20170138922 | SENSING SYSTEM AND METHOD - A system includes a resonant sensor in contact with oil within a gearbox of a rotor system, such as a wind turbine, and one or more processors. The sensor includes electrodes and a sensing circuit that generates electrical stimuli having frequencies applied to the oil at different times during a life of the gearbox. The processors receive electrical signals from the resonant sensor representative of impedance responses of the oil to the electrical stimuli. The processors analyze the impedance responses and determine a concentration of a polar analyte in the oil at different times. The processors calculate a degradation value for the gearbox based on the concentration of the polar analyte. Responsive to the degradation value exceeding a designated threshold, the processors at least one of schedule maintenance for the rotor system, provide an alert to schedule maintenance, or prohibit operation of the rotor system until maintenance is performed. | 2017-05-18 |
20170138923 | APPARATUS AND METHOD FOR DETECTING MICROBES OR BACTERIA - An apparatus and method for detecting microbes use laser speckles. The apparatus includes a light source configured to irradiate light into a sample to detect microbes, and a measuring part configured to measure laser speckles, which are formed due to a multiple scattering of the light which is incident into the sample, every reference time and to measure concentration of the microbes contained in the sample based on temporal correlation of the measured laser speckles. | 2017-05-18 |
20170138924 | AUTOMATED CELL CULTURE SYSTEM AND CORRESPONDING METHODS - Described herein are systems, methods and computer program products for real time assessment and monitoring of biological cells or their environment. In the systems and methods, a computer receives readouts of the biological cells or their environment and assesses changes in the biological cells or their environment by comparing current and previous values of parameters that describe the biological cells or their environment. The computer then determines treatments to be applies to the cells based on the assessing and user-specified criteria and then applies the treatment by controlling a setting on an environmental control unit to cause the treatment to be applied to the biological cells. The systems and methods described herein provide an automated system that includes computer-driven modifications that eliminate the need for the researcher to be present and controlling the flow of the experiment as it is being run. | 2017-05-18 |
20170138925 | Nanopore Structure, Ionic Device Using Nanopore Structure and Method of Manufacturing Nanomembrane Structure - A nanopore structure includes an insulating support member including at least one of silicon and a compound containing silicon and in which a micropore that penetrates one side and the other side is formed in a central portion. The nanopore structure also includes a nanopore film including silicon nitride (SiN), disposed on the insulating support member, and in which a nanopore having a size smaller than that of the micropore is formed in a central portion in order to communicate with the micropore. The nanopore film and the insulating support member are attached by a hydrophilic surface processing. | 2017-05-18 |
20170138926 | SYSTEMS AND METHODS FOR AUTOMATED IMAGE-GUIDED PATCH-CLAMP ELECTROPHYSIOLOGY IN VITRO - Automated, image-guided systems for automatically performing in vitro cell patch clamping are provided. The systems are configured for use with a patch-clamp arrangement and include a camera system for providing images from tissues under investigation and a computer to execute calibration, detection, and whole-cell patching algorithms based on the collected image data. Automated methods for carrying out in vitro cell patch clamping using this automated, image-guided system are also provided and include using images to automatically calibrate a manipulator relative to a tissue of interest, detect and extract coordinates for a plurality of cells, and utilizing the coordinates with a patch-clamp arrangement to automatically move a manipulator directly above each of the plurality of cells and initiate the performance of an automated patch clamp mechanism for each of the plurality of cells driven by the system. | 2017-05-18 |
20170138927 | METHOD AND DEVICE FOR AUTOMATICALLY DETERMINING THE POSITION OF A MICROSYSTEM FOR MANIPULATING A SPHERICAL MICROOBJECT - In a method for automated determination of the relative position (x/y/z) between a first hole ( | 2017-05-18 |
20170138928 | SENSOR CLIP FOR STACKED SENSOR DISPENSING SYSTEM, AND SYSTEMS, METHODS AND DEVICES FOR MAKING AND USING THE SAME - Sensor clip assemblies, sensor clips, analyte testing systems, and methods for making and using the same are disclosed. A sensor clip assembly is disclosed for storing and dispensing analyte testing sensors. The sensor clip assembly includes numerous test sensors arranged in a stack. Each test sensor is configured to assist in testing an analyte in a fluid sample. The sensor clip assembly also includes a skeletal frame with a top, a bottom, and numerous sides. The top, bottom and sides are interconnected to define an internal chamber within which is stored the stack of test sensors. At least one of the sides includes one or more elongated rails with structural gaps on opposing sides thereof. For some configurations, multiple sides of the skeletal frame comprise at least one or multiple elongated rails, each of which has structural gaps on opposing sides thereof and may be columnar in nature. | 2017-05-18 |
20170138929 | PORTABLE BLOOD GLUCOSE MEASUREMENT DEVICE - A portable blood glucose measurement device is provided. The device includes, in an externally exposed way, a temperature measurement medium of which the temperature quickly changes according to outside temperature changes provided on one side surface of a case. The device further includes an infrared temperature sensor. The device measures the temperature of the temperature measurement medium with the infrared temperature sensor in a noncontact manner, and calculates a blood glucose measurement result by considering the measured temperature so as to accurately reflect the outside temperature of an actual blood glucose measuring environment. The temperature measurement medium can be configured to sensitively respond to the outside temperature independently from the case such that the temperature of the temperature measurement medium, in accordance with the change in outside temperature, quickly and accurately changes so as to measure the temperature in a more accurate manner. | 2017-05-18 |
20170138930 | NON-INVASIVE DIAGNOSTIC METHOD FOR THE EARLY DETECTION OF FETAL MALFORMATIONS - A non-invasive method for the early diagnosis of fetal malformations based on the metabolomics analysis of maternal blood is here described. | 2017-05-18 |
20170138931 | METHOD FOR DIAGNOSIS OF INFLAMMATORY DISEASES USING CALGRANULIN C - The present invention is directed to a method for diagnosing inflammatory diseases based on the marker CALGRANULIN C, particularly for diagnosing specific stages of inflammatory diseases and/or for determining the risk of relapse and/or for discriminating between diseases with similar symptoms, said method comprising the steps of (a) obtaining a biological sample of mammalian body fluid or tissue to be diagnosed; (b) determining the amount and/or concentration of CALGRANULIN C polypeptide and/or nucleic acids encoding the polypeptide present in said biological sample; and (c) comparing the amount and/or concentration of CALGRANULIN C polypeptide determine in said biological sample with the amount and/or concentration of CALGRANULIN C polypeptide as determined in a control sample and/or comparing the amount and/or concentration of nucleic acids encoding CALGRANULIN C polypeptide determined in said biological sample with the amount and/or concentration of nucleic acids encoding CALGRANULIN C polypeptides measured in a control sample, wherein the difference in the amount of CALGRANULIN C polypeptide and/or nucleic acids encoding the polypeptide is indicative for the stages of the disease to be diagnosed. | 2017-05-18 |
20170138932 | COMPOSITIONS AND METHODS FOR TREATING CARDIOVASCULAR DISEASE AND MYOCARDIAL INFARCTION WITH DIPEPTIDYL PEPTIDASE INHIBITORS OR B TYPE NATRIURETIC PEPTIDE ANALOGUES RESISTANT TO PROLYL-SPECIFIC DIPEPTIDYL DEGRADATION - The present invention describes compositions and methods for treating cardiovascular disease and myocardial infarction using dipeptidyl peptidase inhibitors. Also provided are methods for increasing natriuretic peptide function by administering one or more analogues of B type natriuretic peptide that provide increased stability in the presence of prolyl-specific dipeptidyl peptidases. | 2017-05-18 |
20170138933 | smFRET WITH MEMBRANE PROTEINS - This disclosure is directed to methods of conducting dynamic single-molecule fluorescence studies such as smFRET on a membrane protein which permits observation and quantification of conformational dynamics of a membrane protein. Also disclosed herein are mutant membrane proteins in which one or more mutations have been introduced for affixing a fluorophore, as well as reagents and kits containing such mutant membrane proteins for conducting dynamic single-molecule fluorescence studies. The methods and compositions disclosed herein can be used in screening for compounds that enhance or reduce the activity of a membrane protein, useful for treating diseases associated with the malfunction of the membrane protein or alterations in membrane protein conformation. | 2017-05-18 |
20170138934 | DEVICE FOR DETECTING TARGET BIOMOLECULES - A device for detecting target biomolecules is provided. The device consists of an electrically conductive membrane having a biological recognition component configured to bind a target biomolecule immobilized thereon. The membrane is connected to an electric circuit by means of electrodes. A voltage source applies a voltage to the membrane and a resistance monitoring device monitors the resistance of the membrane as a selected volume of fluid sample suspected of containing the target biomolecule is delivered onto the membrane. | 2017-05-18 |
20170138935 | BAW SENSOR WITH PASSIVE MIXING STRUCTURES - A fluidic device includes a base structure, a wall structure, and a cover structure bounding a fluidic passage containing a functionalized active region of at least one bulk acoustic wave (BAW) resonator structure. One or more of the wall structure, the cover structure, or a portion of the base structure includes multiple features (e.g., protrusions and/or recesses) configured to interact with fluid flowing within the fluidic passage to promote mixing between constituents of the fluid. Methods for fabricating a fluidic device, as well as methods for biological or chemical sensing using a fluidic device, are further provided. | 2017-05-18 |
20170138936 | METHOD FOR CAPTURING TARGET SUBSTANCE, SOLID-PHASE CARRIER FOR CAPTURING TARGET SUBSTANCE, AND METHOD FOR PRODUCING SOLID-PHASE CARRIER - To provide a solid-phase carrier that has extremely low nonspecific adsorption of biological substances such as proteins, peptides, nucleic acids and cells, and is capable of maintaining the activity of bound ligands at a high level; and a method for capturing a target substance using the solid-phase carrier. | 2017-05-18 |
20170138937 | DETECTION OF ANALYTES - The present disclosure relates to a one-step immunoassay, in which a solid substrate is pre-coated with an immobilisation agent, and whereby the capture agent, the analyte and the detection agent are added to the solid substrate together, followed by a wash step prior to detection. Methods and kits for detecting an analyte in a sample are disclosed. The capture agent can bind the analyte and comprises a ligand for an immobilisation agent. Certain embodiments are directed to antibody capture agents and/or antibody detectable agents. Certain embodiments are directed to a ligand comprising a peptide tag and an immobilisation agent comprising an anti-peptide tag antibody. Certain embodiments are directed to detection of more than one analyte. | 2017-05-18 |
20170138938 | ANALYTICAL METHOD - The present invention provides a method of analyzing a sample containing an analyte to be qualitatively and/or quantitatively determined, comprising a binding step and a washing step, wherein the binding step comprises: interacting the analyte with beads having a density m | 2017-05-18 |
20170138939 | METHOD OF TRANSFERRING BEADS - The present invention provides a method of transferring beads in a fluidic chip comprising an internal fluid circuit through which various reactants, in which at least one of the reactants are beads, may be moved by use of centrifugal force, the method comprises the steps of: providing beads ( | 2017-05-18 |
20170138940 | METHOD FOR ISOLATING TRACE COMPONENTS FROM A BIOLOGICAL LIQUID SAMPLE - A method for isolating trace components selected from various groups and substances as set forth in the disclosure includes a) lysis of the cells and/or b) depletion of proteins by binding on mobile, magnetic silica gel beads and/or c) removal of peptides, amino acids, sugars, lipids, phospholipids and inorganic salts by binding on mobile, magnetic silica gel beads. The binding on the mobile, magnetic silica gel beads under b) and/or c) takes place non-selectively, selectively and/or reversibly, and the isolation of the trace components takes place timely offset after steps b) and/or c) with the aid of magnetic separation by binding on the surface of the mobile, magnetic silica gel beads, which differ from the mobile, magnetic silica gel beads under b) and/or c) in terms of different functional groups. | 2017-05-18 |
20170138941 | DEVICES FOR DETECTING TARGET BIOLOGICAL MOLECULES FROM CELLS AND VIRUSES - Described herein are fluid-manipulation-based devices. Fluid manipulations as described herein can be configured to perform assays on biological samples. In an embodiment, the device includes a reaction chamber, which can includes an integrated sample isolation module, a cell lysis module, a biological target purification module, and an assay mixing module, which can include a microbead with a capture molecule coupled thereto and a nanoparticle having a probe molecule coupled thereto via a label, which can be a spectroscopic label. In an embodiment, the capture and probe molecules can be configured to be coupled together via a biological target to form a biological molecule bead complex. Devices and methods as described herein can manipulate and analyze nanoliter volumes of fluid, microliter volumes of fluid, milliliter volumes of fluid, or greater. Embodiments of the present disclosure can enable random biological assays and rapid, simultaneous analysis of multiple biological samples. | 2017-05-18 |
20170138942 | ARRAYS, SUBSTRATES, DEVICES, METHODS AND SYSTEMS FOR DETECTING TARGET MOLECULES - Arrays and substrates comprising a material, in particular capture agents and/or detectable targets, attached to the substrates along substantially parallel lines forming a barcoded pattern and related methods and systems. | 2017-05-18 |
20170138943 | METHOD AND APPARATUS FOR BIOMOLECULE ANALYSIS - Disclosed are devices or apparatus and methods for membrane-, bead- or cell-based biomolecule analysis, where a detectable signal can be measured after affinity binding and/or enzymatic reaction occurs on the membranes, beads or cells. The apparatus or device can rapidly separate the beads or cells from the liquid solution without using centrifugation, vacuum, or magnetic force. The apparatus or device includes a sample well for receiving a sample containing cells or beads, as well as other aqueous solutions, a porous filter membrane at the bottom of the well which is capable of retaining the cells or beads on its upper surface by size exclusion, and an absorbing plug in touch with the filter membrane for removing the liquid solution. Multiple devices can be arranged in a multi-well array in a plate so that signals from multiple assays can be directly analyzed in a plate reader or an imaging instrument. | 2017-05-18 |
20170138944 | METHOD FOR DETECTING ENZYME ACTIVITY HYDROLYZING BETA-LACTAM RING ANTIMICROBIAL AGENTS - The present invention relates to a method for detecting an enzyme activity capable of hydrolyzing betalactam ring anti-microbial agents in a biological cell, comprising contacting said biological cell with at least one substrate of said enzyme activity comprising a betalactam ring, in an electrochemical cell, and detecting an impedance variation in said electrochemical cell with monitoring means. The present invention is in particular useful for detecting carbapenemase-producing Enterobacteriaceae (CPE). | 2017-05-18 |
20170138945 | METHOD FOR MEASURING ENDOTOXIN - A method for rapidly and highly sensitively measuring endotoxin is provided. Endotoxin is measured using an endotoxin-measuring agent comprising the proteins (1) to (3) below, each of which is a recombinant protein obtainable by being expressed using insect cells as a host:
| 2017-05-18 |
20170138946 | BIOMARKERS FOR RESPONSE TO EZH2 INHIBITORS - The presently disclosed subject matter relates to the use of one or more biomarkers to evaluate the likelihood that an EZH2 inhibitor would produce an anti-cancer effect in a subject. It is based, at least in part, on the discovery that loss of BAP1 results in the upregulation of EZH2 expression and activity. In a specific non-limiting embodiment, the method comprises obtaining a sample of the cancer from a subject, and determining, in the sample, the expression level of an BAP1 biomarker, where if the BAP1 biomarker is absent or expressed at lower level in the cancer as compared to a reference control level, then administering a therapeutically effective amount of an EZH2 inhibitor to produce an anti-cancer effect. | 2017-05-18 |
20170138947 | Biomarker SPAG5 - There has been a recent shift in cancer therapy from one size fits all to a personalized and tailored treatment for individual patients to increase efficiency and avoid unnecessary toxicity. This invention relates to a method of determining the prognosis and suitable treatment of cancer in a subject by measuring the level of expression of SPAG5. In particular, it relates to a method where high expression of SPAG5 in tumour cells correlates with aggressive tumors. | 2017-05-18 |
20170138948 | DIFFERENTIAL CEREBROSPINAL FLUID REACTIVITY TO PFDN5-ALPHA FOR DETECTION OF B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA - A method of managing treatment in a patient with B-cell acute lymphoblastic leukemia (B-ALL) for central nervous system (CNS) leukemia is disclosed. The method comprises obtaining cerebrospinal fluid (CSF) from the patient, obtaining a cell proteome including PFDN5-α from the patient, detecting reactivity of CSF against the PFDN5-α, comparing reactivity profile of CSF against the PFDN5-α at diagnosis and during treatment, and determining the status of proliferation of leukemia in the patient depending on the comparison. The method further comprises treating the patient for CNS leukemia based on the status of proliferation. | 2017-05-18 |
20170138949 | METHOD FOR DIAGNOSING THE RISK OF PRENEOPLASTIC AND NEOPLASTIC LIVER DISEASE IN SUBJECTS AFFECTED BY HEPATITIS - The invention herein described relates to an early and specific diagnosis method based on the use of the peptide fragment 75-99 of the URG7 protein. This peptide is used as an antigen to determine the presence of anti-URG7 antibodies in the sera of carrier subjects of the hepatitis virus, of hepatitis B in particular. | 2017-05-18 |
20170138950 | IDENTIFICATION OF CANCER PROTEIN BIOMARKERS USING PROTEOMIC TECHNIQUES - The claimed invention describes methods to diagnose or aid in the diagnosis of cancer. The claimed methods are based on the identification of biomarkers which are particularly well suited to discriminate between cancer subjects and healthy subjects. These biomarkers were identified using a unique and novel screening method described herein. The biomarkers identified herein can also be used in the prognosis and monitoring of cancer. The invention comprises the use of leptin, prolactin, OPN and IGF-II for diagnosing, prognosis and monitoring of ovarian cancer. | 2017-05-18 |
20170138951 | IMMUNOASSAY METHODS - The present invention generally relates to the field of antibody detection, and in particular relates to assays for the detection of antibodies in a sample comprising patient bodily fluid. The invention provides a method of detecting an antibody in a test sample comprising a bodily fluid from a mammalian subject, wherein the test sample is contacted with a plurality of different amounts of an antigen specific for the antibody, the amount of specific binding between the antibody and the antigen is detected and the presence or absence of antibody is determined based upon the amount of specific binding between the antibody and the antigen and a secondary curve parameter arising from a curve of the amount of specific binding versus the amount of antigen for each amount of antigen used. | 2017-05-18 |
20170138952 | METHOD AND SYSTEM FOR DETECTING A TARGET WITHIN A POPULATION OF MOLECULES - A method of detecting a target within a population of molecules comprising: contacting a plurality of labeled probe molecules with the population of molecules potentially containing a target of the probe molecules; acquiring a probe specific signal emitted by said labeled probe molecules that bound to said target together with a background signal; preferentially modulating said probe specific signal by at least one of modulating said acquisition and modulating an emission of said probe specific signal; and detecting said probe specific signal over said background signal using said preferential modulation. | 2017-05-18 |
20170138953 | METHODS FOR DETECTING AND QUANTIFYING NON-POLAR ANALYTES WITH HIGH SENSITIVITY - The technology of the present application is directed to methods and kits for detecting and quantifying a non-polar analyte in a plant-derived sample. The technology uses a simple extraction, e.g., a liquid-liquid extraction (LLE) or solid-phase extraction (SPE), to enrich a sample for a non-polar analyte of interest and to remove contaminants. After the extraction and clean-up steps, liquid chromatography and mass spectrometry are used to detect the non-polar analyte. In one embodiment, acequinocyl and/or its derivatives is analyzed using liquid chromatography and tandem mass spectrometry (LC-MS/MS) and the improved LC-MS/MS conditions allows detection limits of acequinocyl and/or its derivatives of 50 ppb or less. | 2017-05-18 |
20170138954 | TEST KITS FOR ELECTRONIC ANALYTE ASSAYING - An improved qualitative or semi-quantitative diagnostic test for low levels of any analyte, such as hCG, in a biological sample, such as urine. The test comprises of a test device containing reagents for the detection of the monitored analyte and an electronic reader that measures color development at a detection area of the device. The color development is converted to an electronic or digital signal. Improvements were made to the detection process to optimize the detection of a valid fluid front, increase the detection limit without compromising the reliability and accuracy of the test system, and improve the determination of test result validity. | 2017-05-18 |
20170138955 | QUANTITATIVE PEPTIDE ANALYSIS BY MASS SPECTROMETRY - A method for determining the concentration ratio in a sample of a target peptide to a reference peptide that is chemically identical with the target peptide, but labeled by isotopes, acquires mass spectra of the target and reference peptides. One of a plurality of families of superimposed bell-shaped curves which is a best fit to ion current peak groups of the target and reference peptides in the mass spectra is determined by varying parameters of the families. In each family, each bell-shaped curve has a predetermined height, the curves have fixed distances from each other and the relative curve heights and curve distances in the families are individually calculated from an elemental composition of the peptides and an isotope abundance distribution of elements composing the peptides, taking into account purity of the isotopes. The concentration ratio is then determined from the parameters of the best fit. | 2017-05-18 |
20170138956 | METHODS OF DETERMINING SEROTYPE SPECIFICITY OF AN ANTIBODY - Methods of determining serotype specificity of an antibody that binds to a serotype of a pathogen are provided. Aspects of the methods include producing an assay mixture and evaluating the assay mixture for the presence of an antibody-pathogen-detectable label binding complex to determine the serotype specificity of the antibody. The assay mixture includes the antibody, at least first and second serotypes of the pathogen, a first detectable label that specifically binds to the first serotype of the pathogen, and a second detectable label that specifically binds to the second serotype of the pathogen. The methods find use in a variety of applications, such as for example determining the serotype specificity and/or cross reactivity of an antibody (e.g., an anti-dengue virus antibody). | 2017-05-18 |
20170138957 | METHOD FOR DIAGNOSING, TREATING, OR PREVENTING MOOD DISORDER - An object of the present invention is to provide a novel method of diagnosing and/or treating a mood disorder, the method being superior to the conventional technologies. The present invention attains the object by providing a method of diagnosing and/or treating a mood disorder by use of an anti-SITH-1 antibody level and an anti-HHV-6 antibody level each serving as an index. | 2017-05-18 |
20170138958 | METHOD FOR MEASURING ANTI-WT1 ANTIBODY - Provided is an invention relating to a method for measuring an anti-WT1 antibody in a sample allowing measurement and evaluation of the anti-WT1 antibody with higher accuracy and to use of the method. The method for measuring an anti-WT1 antibody in a sample includes using a polypeptide having antigenicity to the anti-WT1 antibody selected from a polypeptide comprising the amino acid sequence of positions 294-449 in SEQ ID NO: 1, a partial polypeptide of the polypeptide, and a polypeptide including an amino acid sequence having deletion, substitution, or addition of one to several amino acids in the amino acid sequence constituting each of these polypeptides and/or a polypeptide having antigenicity to the anti-WT1 antibody selected from a polypeptide comprising the amino acid sequence of positions 181-324 in SEQ ID NO: 1, a partial polypeptide of the polypeptide, and a polypeptide including an amino acid sequence having deletion, substitution, or addition of one to several amino acids in the amino acid sequence constituting each of these polypeptides. | 2017-05-18 |
20170138959 | Deglycosylation Reagents and Methods - Compositions and methods are provided for efficiently preparing a completely deglycosylated antibody where efficiency is measured in relative amounts of reagents in soluble or lyophilized form, and time and temperature of the reaction. Compositions and methods are also provided for separating substantially all N-linked glycans from a glycosylated antibody and for preserving functionality of the antibody. The methods are compatible with glycan labeling and protease digestion without the need for prior purification steps. | 2017-05-18 |
20170138960 | DETECTION, MONITORING AND TREATMENT OF ACUTE MYOCARDIAL INFARCTION - Detection, monitoring and treatment of acute myocardial infarction (AMI) using a hybrid immunoassay to both Lp-PLA2 and ApoA1. Described herein are assays and method of performing them useful for the detection of AMI. Also described are methods of monitoring a patient at risk for, or suffering from, AMI. Also described herein are methods and assays for treating patient having or at risk of suffering from AMI. | 2017-05-18 |
20170138961 | NEW MARKERS FOR THE ASSESSMENT OF THE RISK FOR DEVELOPMENT OF A CARDIOVASCULAR DISORDER - The present invention relates to the assessment of the risk for development of a cardiovascular disorder. It discloses the use of biochemical markers in the assessment of the risk for development of a cardiovascular disorder. It also relates to the use of the biochemical markers or marker panels for the assessment of the risk for development of a cardiovascular disorder and to kits for performing the methods of the invention. | 2017-05-18 |
20170138962 | HEALTH TEST FOR A BROAD SPECTRUM OF HEALTH PROBLEMS - Provided herein are methods and devices for the detection of conditions or disorders by detecting altered levels of stress response pathway biomarkers. Also provided are methods and reagents for identifying panels of biomarkers associated with a condition or disorder. | 2017-05-18 |
20170138963 | MARKERS OF THE MALE UROGENITAL TRACT - Methods for detecting urogenital conditions or urogenital status in a subject are described comprising measuring urogenital markers or polynucleotides, encoding the markers in a sample from the subject. The invention also provides localization or imaging methods for urogenital conditions, and kits for carrying out the methods of the invention. The invention also contemplates therapeutic applications for urogenital conditions employing urogenital markers, polynucleotides encoding the markers, and/or binding agents for the markers. | 2017-05-18 |
20170138964 | Systems, Assays, and Methods for Determining Risk Factors for Alzheimer's Disease - A method of determining risk factors for Alzheimer's disease in an individual, including assaying a biological medium obtained from the individual for a biomarker selected from Biomarker 1, Biomarker 2, Biomarker 3, or Biomarker 4, where Biomarker 1 has a mass-to-charge ratio (m/z) of 602.3, Biomarker 2 has a m/z of 804.6, Biomarker 3 has a m/z of 874.6, and Biomarker 4 has a m/z of 804.5, and where the presence of the two or more biomarkers in the individual indicates a risk factor of Alzheimer's disease. | 2017-05-18 |
20170138965 | Nanoveson(TM): Treatment, Biomarkers and Diagnostic Tests for Liver Diseases and Comormid Disease - A method of treatment of liver diseases and comorbid diseases is disclosed wherein an oral dose of lipids in an amount effective to trigger the release of cholecystokinin (CCK) into the duodenum to generate a major release of bile phospholipids from remodeled stores of triglycerides (TAG) in the liver, is administered to a patient in need thereof, thereby causing the formation of sequestered and aggregated mixed micelles and vesicles (SAMMVs) in the intestines of the patient which are then eliminated via the bowels of the patient. | 2017-05-18 |
20170138966 | SYNTHETIC ANTIGEN COMPOSITIONS FOR DETECTING ANTI-PHOSPHATIDYLETHANOLAMINE ANTIBODIES - Provided herein are compositions comprising distinct lipid species in defined ratios and methods of use thereof for the detection of anti-phosphatidylethanolamine (aPE) antibodies and diagnosis of antiphospholipid syndrome (APS). | 2017-05-18 |
20170138967 | METABOLICS BIOMARKER FOR NAFLD AND METHODS OF USE - The present disclosure provides metabolomics biomarkers for NAFLD and indicative of liver fibrosis and methods of using same. | 2017-05-18 |
20170138968 | ApoIII and the Treatment and Diagnosis of Diabetes - The present invention provides methods of identifying candidate compounds for the treatment of type I diabetes comprising contacting pancreatic β cells with an amount of apolipoprotein CIII (“apoCIII”) effective to increase intracellular calcium concentration, in the presence of one or more test compounds, and identifying those test compounds that inhibit an apoCIII-induced increase in intracellular calcium concentration in the pancreatic β cells. The present invention also provides methods for treating patients with type I diabetes comprising administering to the patient an amount effective of an inhibitor of apoCIII to reduce apoCIII-induced increase in intracellular calcium concentration in pancreatic β cells. | 2017-05-18 |
20170138969 | System And Method For Measuring Permeability Of Drugs/Toxic/Chemical Compounds - This invention relates to a system and method for measuring the permeability of drugs/toxin chemical compounds utilizing phospholipid monolayer. A phospholipid monolayer can be deposited onto a cellulose membrane by vertical lifting or Langmuir Schafer technique. The phospholipid monolayer or Langmuir Blodgett (LB) film can be coated on the cellulose membrane or porous support. | 2017-05-18 |
20170138970 | Compounds and Methods for Use in Detecting Gabapentin - Compounds and methods for use in detecting gabapentin in a sample suspected of containing gabapentin are disclosed. Gabapentin derivatives are used to produce gabapentin conjugates. A gabapentin-immunogenic carrier conjugate may be used as an immunogen for the preparation of an anti-gabapentin antibody. A gabapentin-detectable label may be used in a signal producing system in gabapentin assays. | 2017-05-18 |
20170138971 | LABORATORY SAMPLE DISTRIBUTION SYSTEM AND CORRESPONDING METHOD OF OPERATION - A laboratory sample distribution system is presented. The laboratory sample distribution system comprises a number of container carriers. The container carriers each comprise at least one magnetically active device such as, for example, at least one permanent magnet, and carry a sample container. The system further comprises a transport plane to carry the container carriers and a number of electro-magnetic actuators being stationary arranged below the transport plane. The electro-magnetic actuators move a container carrier on top of the transport plane by applying a magnetic force to the container carrier. | 2017-05-18 |
20170138972 | SUBSTRATE FOR SAMPLE ANALYSIS, SAMPLE ANALYSIS DEVICE, SAMPLE ANALYSIS SYSTEM, AND PROGRAM FOR SAMPLE ANALYSIS SYSTEM - A substrate for sample analysis on which transfer of liquids is to occur with rotational motion, includes a substrate having a rotation axis; a first chamber and a second chamber being located in the substrate and respectively having a first space and a second space for retaining a first liquid and a second liquid; a third chamber being located in the substrate and having a third space for retaining the liquids to be discharged from the first chamber and the second chamber; a first channel having a path connecting the first chamber and the third chamber to transfer the first liquid; and a second channel having a path connecting the second chamber and the third chamber to transfer the second liquid. | 2017-05-18 |
20170138973 | AUTOMATIC ANALYZER AND METHOD - The present disclosure includes an automatic analyzer and a method for the determination of a measurand dependent upon the concentration of one or more ingredients of a measuring fluid. The analyzer includes a measuring cell includes a cuvette and a sensing element, the sensing element including at least one radiation source and at least one detector configured to generate measurement signals, a control and evaluation unit that is connected to the sensing element to receive and process measurement signals of the sensing element, and a delivery and metering unit that can be controlled by the control and evaluation unit, where the control and evaluation unit is configured to control the delivery and metering unit to transport measuring fluid into the cuvette and to monitor the transport of the measuring fluid into the cuvette by means of the sensing element. | 2017-05-18 |
20170138974 | DEVICE FOR STORING BIOCHEMICAL REAGENTS, AND BIOCHEMICAL ANALYZER - Provided are: a device for storing biochemical reagents wherein an amount of a reagent can be hermetically stored and dropped from a storage site without coming into contact with the outside air; and a biochemical analyzer using the device. The device ( | 2017-05-18 |
20170138975 | Laser Triangulation For Pipette Tip Position - A sample processing apparatus includes a laser triangulation system that locates the position of a lower end of a pipette tip. When the laser triangulation system identifies a discrepancy between the actual position of the lower end and the proper position of the lower end, the sample processing apparatus may undergo a compensating action to compensate for the discrepancy. | 2017-05-18 |
20170138976 | SYSTEMS AND METHODS FOR DETECTING A LIQUID LEVEL - A method for detecting a liquid surface of a liquid sample with a pipetting tip, the method includes receiving an indication of a capacitance of the pipetting tip, and determining, based on a rate of change of the indication of the capacitance rising above a first preselected threshold, that the pipetting tip has come into contact with the liquid surface. The method also includes determining, based on the rate of change of the indication of the capacitance falling below a second preselected threshold, that the pipetting tip has lost contact with the liquid surface. | 2017-05-18 |
20170138977 | IMMUNODIAGNOSTIC TEST ELEMENT HAVING WEAKENED FOIL LAYER - An immunodiagnostic test element includes a support member, at least one test column containing a test material, and a wrap, such as an adhesively-attached foil wrap, covering the top of the at least one test element. The wrap includes a weakened portion directly above each test column, in which each weakened portion is formed by pre-stressing the portion, but not to the point of puncturing the wrap to enable the wrap to be punctured by a fluid aspirating/dispensing element, such as a metering tip, permitting access to the contents of the test column. | 2017-05-18 |
20170138978 | MONITORING THE STRUCTURAL HEALTH OF COLUMNS - A method and apparatus for monitoring the structural health of a stock of columns such as lighting columns and/or columns within that stock each of which is connected to receive power from an external source or otherwise. The method comprises the steps of locating on an upper surface of each or a plurality of columns within the stock to be monitored a micro controller connected to receive power from the electrical source of the respective column. The micro controller includes an electronic chip or board which includes, in circuit, an accelerometer, a Wi-Fi/RF or 3G/4G component or the like and a global positioning system (GPS) component or the like. The micro controller is operable to detect and monitor the magnitude and direction of forces imposed on the respective column and the direction from which such forces are derived, and to transmit the received data to a remote server for analysis. | 2017-05-18 |
20170138979 | ENERGY-EFFICIENT HOME-AUTOMATION DEVICE AND METHOD FOR TRACKING THE DISPLACEMENT OF A MONITORED OBJECT - Disclosed is a home-automation device including a displacement detector for a monitored object, an accelerometer, an orientation sensor, a memory, a processing unit. The processing unit is programmed to calculate, upon detection of an event, a displacement energy of the detector from the acceleration signals acquired during a waiting time after the triggering event. | 2017-05-18 |
20170138980 | THERMALLY INSENSITIVE OPEN-LOOP HUNG MASS ACCELEROMETER WITH DIFFERENTIAL EDDY CURRENT SENSING - A thermally insensitive open-loop hung mass accelerometer utilizes a transverse geometry to attach the body/flexures/proof mass so that thermal expansion effects due to thermal gradients across the accelerometer or bulk temperatures changes of one flexure relative to the other cause minimal or no axial displacement of the proof mass. In this geometry, multiple flexures may be stacked to achieve the required stiffness, thus reducing manufacturing costs and any tolerancing issues, without affecting thermal sensitivity. The accelerometer is suitably designed to exhibit a radial symmetry. The accelerometer is suitably designed to use low CTE materials for at least the proof mass and body and a low thermal expansion differential Eddy current sensor head. | 2017-05-18 |
20170138981 | Acceleration Sensor - Provided is a highly reliable acceleration sensor that keeps production costs low and has low zero point drift initially and over time even when used in a poor installation environment. In this acceleration sensor, a weight that rotates when acceleration is applied in the z-direction is disposed in a cavity surrounded by a support substrate and a cap layer. The cap layer is formed such that both sides thereof across the axis of rotation of the weight have different masses per unit area. | 2017-05-18 |
20170138982 | METHOD OF MEASURING A TOPOGRAPHIC PROFILE AND/OR A TOPOGRAPHIC IMAGE - Measuring a topographic profile and/or a topographic image of a surface of a sample includes positioning an indenter out of contact with a sample and in a constant position with respect to a headstock; positioning a topographic tip to detect a surface of the sample and positioning a reference structure at a predetermined distance from said surface; measuring the relative position of the indenter with respect to the reference structure by a relative position sensor; translating said sample perpendicular to said longitudinal axis while maintaining the reference structure at said predetermined distance from the surface of the sample by the feedback control system and the second actuator while measuring the relative position of the indenter with respect to the reference structure by the relative position sensor; and generating a topographic profile and/or a topographic image based on measurements of the relative position. | 2017-05-18 |
20170138983 | HEAD-INTEGRATED ATOMIC FORCE MICROSCOPE AND COMPOSITE MICROSCOPE INCLUDING SAME - An object of the application is to provide a head-integrated for an atomic force microscope capable of realizing minimization of a weight and a volume and improvement of structural stability by optimizing a head structure of the atomic force microscope. Another object of the application is to provide a head-integrated atomic force microscope capable of being utilized for imaging a large-area sample by enabling high-rate head scan due to dynamic characteristics improved by mounting the integrated-head described above. Still another object of the application is to provide a composite microscope including a head-integrated atomic force microscope, capable of performing high-rate position search and imaging and performing precise observation of a three-dimensional shape up to an atomic image level in a region of interest by combining the head-integrated atomic force microscope having the improved dynamic characteristics as described above and an electron microscope or an optical microscope with each other. | 2017-05-18 |
20170138984 | EVALUATION APPARATUS FOR SEMICONDUCTOR DEVICE AND EVALUATION METHOD FOR SEMICONDUCTOR DEVICE - An evaluation apparatus for a semiconductor device includes: a chuck stage that has a surface on which a plurality of probe holes are formed and sucks a semiconductor device; and a plurality of in-chuck probes that have first ends which are inserted into the respective probe holes, and second ends which protrude from the surface of the chuck stage, and come into contact with an arrangement surface of the semiconductor device arranged in the chuck stage, wherein a height protruding from the surface of the chuck stage of at least one of the in-chuck probes is different from a height protruding from the surface of the chuck stage of the other in-chuck probe. | 2017-05-18 |
20170138985 | PROBE PIN AND ELECTRONIC DEVICE USING THE SAME - A probe pin includes a coil spring, a first plunger, and second and third plungers. The second and third plungers respectively are independently operable and include a main body and first and second elastic pieces that extend from the main body in the same direction to each other. The first plunger is inserted between the first and second elastic pieces each of the second and third plungers. | 2017-05-18 |