19th week of 2012 patent applcation highlights part 54 |
Patent application number | Title | Published |
20120116022 | PROCESS FOR MAKING ETHYLENE POLYMER BLENDS WITH CONTROLLED LONG-CHAIN BRANCHING - A high-temperature solution process for making an ethylene polymer blend having a controlled degree of long-chain branching is disclosed. Ethylene is polymerized in the presence of a first Ziegler-Natta catalyst comprising titanium, magnesium, and aluminum in the absence of hydrogen to produce a first ethylene polymer component having substantial long-chain branching. A second ethylene polymer component having little or no long-chain branching is also prepared. Both polymerizations are performed at a temperature from 140° C. to 250° C. The first and second ethylene polymer components are combined to give a polymer blend. The degree of long-chain branching in the blend is controlled by adjusting the relative amounts of the first and second ethylene polymer components. The invention enables the preparation of valuable products having a pre-determined degree of long-chain branching using readily available Zeigler-Natta catalysts, commercially practiced techniques, and conventional equipment. | 2012-05-10 |
20120116023 | METHOD FOR CONTROLLING ANIONIC POLYMERIZATION - This invention deals with an approach to control anionic polymerization. The anionic polymerization is conducted by adding a kind of initiator ligand compound, directly or in the form of solution into the monomer or initiator at the same or different time, or at different stages. The metal atoms in the ligand can form the association with the initiator cations, while the alkyloxy groups in the intiator ligand can restrict the entering channel of the addition of the monomers due to their relatively large volume or steric hindrance. Therfore, the initiator ligand compound can restrict the rate of anionic polymerization, restrain the side reaction, and make the anionic polymerization possible to be conducted at room or even higher temperature. | 2012-05-10 |
20120116024 | SELF-SUPPORTING THIN POLYMER FILM - [Object] To provide a self-supporting thin polymer membrane having a large surface area, a high strength, and a perpendicularly oriented cylindrical structure, and to provide a method of producing the membrane. | 2012-05-10 |
20120116025 | VINYL ESTER RESIN COMPOSITION - The present invention relates to a resin composition comprising (a) from 30 to 70 wt. % of a vinyl ester resin, (b) from 30 to 70 wt. % of reactive diluent, wherein the resin composition comprises methacrylate containing compound and an itaconate ester as reactive diluent. | 2012-05-10 |
20120116026 | PROCESS FOR DEGRADING NITRILE RUBBERS IN THE PRESENCE OF CATALYSTS HAVING AN INCREASED ACTIVITY - A process of degrading nitrile rubbers comprises subjecting them to a metathesis reaction in the presence of specific catalysts with increased activity. | 2012-05-10 |
20120116027 | PROCESS FOR THE PURIFICATION OF HUMAN GROWTH HORMONE POLYPEPTIDES USING AFFINITY RESINS COMPRISING SPECIFIC LIGANDS - The present invention relates to a novel process for the purification of growth hormone polypeptides, e.g. recombinant human Growth Hormone. The process utilizes an affinity resin comprising a solid phase material having immobilized thereto one or more low-molecular weight synthetic ligands. The affinity resins enable the separation of Growth Hormone from closely related proteins. | 2012-05-10 |
20120116028 | METHOD FOR PRODUCING POLYCARBONATE MATERIAL HAVING EXCELLENT SOLUBILITY AND AFFINITY, AND CONTACT LENS MATERIAL COMPRISING THE SAME - According to the present invention, a contact lens material being excellent in oxygen permeability and transparency, being capable of undergoing injection molding, having no water content and having flexibility, as well as a contact lens gel material having excellent oxygen permeability and transparency can be provided. The present invention relates to a contact lens material comprising a polycarbonate resin derived from at least two compounds among compounds represented by a general formula (A), a general formula (B) and a general formula (C), a highly polar molecular weight control modifier (chain terminator) and a compound forming a carbonic acid ester, wherein the compound of the general formula (A) is essentially comprised, and to a production method thereof. | 2012-05-10 |
20120116029 | METHOD FOR POLYMERIZING POLYPROPYLENE - The present disclosure relates to a method for polymerizing polypropylene, optionally with one or more additional comonomers in a gas phase reactor in the presence of a mixed electron donor system comprising at least one selectivity control agent and at least one activity limiting agent. The process involves controlling the polymerization process to ensure that the difference between the reactor temperature and the dew point temperature of the incoming monomer stream is 12° C. or greater. | 2012-05-10 |
20120116030 | PROCESS FOR CONTINUOUSLY PRODUCING THERMOPLASTICALLY PROCESSABLE POLYURETHANES - The invention relates to a process for continuously producing thermoplastically processable polyurethanes in a recycle reactor with flexibly adjustable mixing conditions. | 2012-05-10 |
20120116031 | High Activity Catalyst Component for Olefin Polymerization and Method of Using the Same - A catalyst system containing (a) a solid catalyst component containing a titanium halide, a magnesium halide, a first internal electron donor compound, and a second internal electron donor compound, (b) an organoaluminum compound, and (c) an external electron donor compound is disclosed. The first internal electron donor compound contains at least one ether group and at least one ketone group. The second internal electron donor compound is a 1,8-naphthyl diester compound. Methods of polymerizing or copolymerizing alpha-olefins using the catalyst system also are disclosed. | 2012-05-10 |
20120116032 | PROCESS FOR THE PREPARATION OF POLYMER OF 1-BUTENE - A process for the preparation of 1-butene homopolymers or 1-butene/alpha olefin copolymers wherein the alpha olefins are selected from ethylene, propylene or alpha olefins of formula CH | 2012-05-10 |
20120116033 | Catalyst Components, Process for Their Preparation and Their Use as Catalyst Components in Polymerization of Olefins - Catalyst compositions having Cs symmetry and processes utilizing Cs symmetric catalyst components for the polymerization of ethylenically unsaturated monomers to produce polymers, including copolymers or homopolymers. Monomers, which are polymerized or copolymerized include ethylene, C | 2012-05-10 |
20120116034 | SOLUTION POLYMERIZATION PROCESS AND PROCATALYST CARRIER SYSTEMS USEFUL THEREIN - A procatalyst carrier system which includes one or more paraffinic solvents, one or more paraffin-insoluble procatalysts, and optionally one or more cocatalysts wherein the carrier system is in the form of a slurry is provided. Also provided is a process including selecting one or more paraffin-insoluble organometallic procatalysts; adding the one or more procatalysts to a sufficient quantity of paraffinic solvent to form a slurry of the one or more procatalysts in the paraffinic solvent; introducing one or more first cocatalysts into a polymerization reactor; and introducing the slurry into the polymerization reactor; a reaction product of the process and articles made from the reaction product. | 2012-05-10 |
20120116035 | HIGH ACTIVITY, LOW MOLECULAR WEIGHT OLEFIN POLYMERIZATION PROCESS - Group 4 metal complexes comprising a polyvalent, heteroaryl donor ligand and their use as components of olefin polymerization catalysts, especially suited for preparing propylene/ethylene copolymer products having high isotacticity and low molecular weight, are disclosed. | 2012-05-10 |
20120116036 | PRODUCTION METHOD OF COPOLYMER OF ALLYL MONOMER CONTAINING POLAR GROUP - The present invention relates to a method for producing a high-molecular-weight copolymer of polar group-containing allyl monomers including monomer units represented by formulae (3) and (4) (in the formulae, R | 2012-05-10 |
20120116037 | ORGANIC THIN FILM TRANSISTOR, SURFACE LIGHT SOURCE AND DISPLAY DEVICE - An organic thin-film transistor of the invention comprises an organic semiconductor layer that contains a polymer compound having a repeating unit represented by the following formula (1) and/or a repeating unit represented by the following formula (2), and a repeating unit represented by the following formula (3). | 2012-05-10 |
20120116038 | RESIST COMPOSITION FOR IMMERSION EXPOSURE, METHOD OF FORMING RESIST PATTERN, AND FLUORINE-CONTAINING RESIN - A resist composition for immersion exposure including: a base component (A) which exhibits changed solubility in an alkali developing solution under the action of acid; an acid-generator component (B) which generates acid upon exposure; and a fluorine-containing resin component (F); dissolved in an organic solvent (S), the fluorine-containing resin component (F) including a structural unit (f1) containing a fluorine atom, a structural unit (f2) containing a hydrophilic group-containing aliphatic hydrocarbon group, and a structural unit (f3) derived from an acrylate ester containing a tertiary alkyl group-containing group or an alkoxyalkyl group. | 2012-05-10 |
20120116039 | METHOD FOR THE PRODUCTION OF TERPOLYMERS BASED ON VDF, TRFE AND CFE, OR CTFE - A process for manufacturing terpolymers by polymerization of VDF (vinylidene difluoride), TrFE (trifluoroethylene), and CFE (1-chloro-1-fluoroethylene) or CTFE (chlorotrifluoroethylene) monomers in the presence of a radical polymerization initiator, characterized in that:
| 2012-05-10 |
20120116040 | Compositions having HASE rheology modifiers - A monomer compound that contains at least one polymerizable functional group per molecule, and at least one bicycloheptyl-, bicycloheptenyl-, or branched (C | 2012-05-10 |
20120116041 | REACTIVE SYSTEMS CONTAINING FORMAMIDES - The invention relates to novel formamides derived from diamines or triamines. As compared to amines, these formamide-terminated compositions have a decelerated reactivity to polyisocyanates, that is, prepolymers. | 2012-05-10 |
20120116042 | Method of synthesizing tuneably high functionality in high molecular weight natural oil polyols - Methods of one-pot synthesis of high molecular weight natural oil polyols having a functionality of between about 4 and about 8 are provided. The resultant polyols may be directly reacted with polyisocyanates to produce polyurethanes. | 2012-05-10 |
20120116043 | Method for providing higher molecular weight natural oil polyols without loss of functionality - Methods of one-pot synthesis of high molecular weight natural oil polyols having a functionality of at least two are provided. The resultant polyols may be directly reacted with polyisocyanates to produce polyurethanes. | 2012-05-10 |
20120116044 | POLYETHERESTER POLYOLS - The present invention relates to hydrophobic polyetherester polyols, to a process for preparing them, and to the use of the polyetherester polyols of the invention for producing polyurethanes. | 2012-05-10 |
20120116045 | Liquid Crystal Alignment Agent, Liquid Crystal Alignment Film Manufactured Using the Same, and Liquid Crystal Display Device Including the Liquid Crystal Alignment Film - Disclosed is a liquid crystal alignment agent including a polymer including polyamic acid including a repeating unit represented by Chemical Formula 1, polyimide including a repeating unit represented by Chemical Formula 2, or a combination thereof. | 2012-05-10 |
20120116046 | SYNTHESIS OF DIAMINODINITROPYRIDINE - A process for the preparation of diaminodinitropyridine or diaminodinitrobenzene by contacting an aminopyridine or aminobenzene with oleum and nitric acid, wherein the improvement comprises adding at least about 1% molar excess of nitric acid, based upon the aminopyridine or aminobenzene, with stirring for at least two hours to form first the intermediate sulfonic acid, and then diaminodinitropyridine or diaminodinitrobenzene, and use of such products in the preparation of rigid rod polymers is disclosed. | 2012-05-10 |
20120116047 | PROCESS FOR PREPARING CONDENSATION RESINS AND THE USE THEREOF - The present invention relates to new condensation resins formed from urea, formaldehyde and CH-acidic aldehydes, to processes for preparing them, and to use thereof. | 2012-05-10 |
20120116048 | Coating Compositions for Containers and Methods of Coating - This invention provides a coating composition for use on a food-contact surface of a container (e.g., a food or beverage can) that includes a polymer having one or more segments of Formula I: | 2012-05-10 |
20120116049 | PURIFICATION OF A CONVENTIONAL POLYMER FLOW CONTAMINATED WITH PLA - Method for purifying a conventional polymer stream (PE, PP, PET, PVC, etc.) contaminated with not more than 50% PLA, comprising steps for the suspension of the polymer with solubilisation of the PLA fraction and the recovery of the purified polymer after separation. | 2012-05-10 |
20120116050 | PYRENE-BASED POLYMERS FOR ORGANIC LIGHT EMITTING DIODES (OLEDS) - The present invention relates to novel pyrene-based polymers, methods of preparing the same and uses thereof, in particular for electroluminescent devices. The novel polymers of the invention have the following general formula (I): wherein R | 2012-05-10 |
20120116051 | Polymer Conjugate Of Bioactive Substance Having Hydroxy Group - A polymer conjugate of a physiologically active substance, which enables drug release independent of a biological enzyme and can be expected to have a high therapeutic effect, is demanded. | 2012-05-10 |
20120116052 | Nucleic Acid Molecules Encoding TNF-Alpha Ligand Polypeptides Having a CD154 Domain - The present invention is directed to an isolated polynucleotide sequence encoding a chimeric TNFα, comprising a first nucleotide sequence encoding a domain or subdomain of a tumor necrosis factor ligand other than TNFα, wherein the encoded domain or subdomain replaces a cleavage site of native TNFα, and a second nucleotide sequence encoding a domain or subdomain of native TNFα that binds to a TNFα receptor. The encoded chimeric TNFα is significantly less susceptible to cleavage from the cellular surface and, as a result can increase the concentration of a ligand capable of binding to a TNFα receptor on the surface of a cell. The chimeric TNFα is therefore useful in methods for inducing apoptosis of a cell expressing a TNFα receptor, inducing activation of an immune system cell and treating neoplastic cells, by introducing into the cell of interest an isolated polynucleotide sequence encoding a chimeric TNFα that is expressed on the surface of the cell. | 2012-05-10 |
20120116053 | EXPRESSION OF TRIPLE-HELICAL COLLAGEN-LIKE PRODUCTS IN E.COLI - Recombinant bacterial triple-helical collagen-like proteins comprising two or more repetitive sequences of Gly-Xaa-Yaa yielding high-stability polymeric constructs without the need for post-translational modifications and which may incorporate one or more functional domains of biological or structural importance. The polymers are capable of high-yield production for a variety of applications | 2012-05-10 |
20120116054 | CONCENTRATED PROTEIN LYOPHILATES, METHODS, AND USES - The invention provides, among other things, lyophilized compositions of high surface area that comprise a protein and that reconstitute quickly and efficiently to solution of high protein concentration with minimal formation, if any, of foam, effervescence, bubbles, turbidity, or particulates that might be deleterious. The invention also provides, among other things, methods for making the lyophilized compositions. The invention in additional aspects also provides Raman Imaging Spectrographic methods for real time analyses of polymorphs in a sample using PLS algorithms. By way of particular example, the use of the method for the analysis of mannitol polymorphs is described, and the use of the analysis to determine optimum compositions and lyophilization methods for producing lyophilates of pharmaceutical proteins having a predefined distribution of mannitol polymorphs and having the aforementioned reconstitution properties is also described. | 2012-05-10 |
20120116055 | NOVEL CANOLA PROTEIN ISOLATE - A novel canola protein isolate consisting predominantly of 2S canola protein and having improved solubility properties, has an increased proportion of 2S canola protein and a decreased proportion of 7S canola protein. The novel canola protein isolate is formed by heat treatment of aqueous supernatant from canola protein micelle formation and precipitation, to effect precipitation of 7S protein which is sedimented and removed. | 2012-05-10 |
20120116056 | Fc fusion proteins of human growth hormone - Fc fusion proteins of human growth hormone with good biological activities relative to rhGH on a molar basis are disclosed. The hGH-L-vFc fusion protein comprises hGH, a flexible peptide linker of about 20 or fewer amino acids, and a human IgG Fc variant. The Fc variant is of a non-lytic nature and shows minimal undesirable Fc-mediated side effects. A method is also disclosed to make or produce such fusion proteins at high expression levels. Such hGH-L-vFc fusion proteins exhibit extended or prolonged serum half-life and/or good biological activities relative to that of rhGH on a molar basis, leading to improved pharmacokinetics and pharmacodynamics, thus fewer injections will be needed within a period of time. | 2012-05-10 |
20120116057 | DESIGN OF STABLE AND AGGREGATION FREE ANTIBODY FC MOLECULES THROUGH CH3 DOMAIN INTERFACE ENGINEERING - The present invention relates to methods of increasing stability and reducing aggregation in compositions comprising antibody Fc molecules and to composition comprising such molecules. Certain amino acid substitutions in the CH3 domain result in increased stability and reduced aggregation of compositions containing polypeptides comprising a CH3 domain, e.g., an antibody or Fc-fusion protein. | 2012-05-10 |
20120116058 | URA5 Gene and Methods for Stable Genetic Integration in Yeast - A novel gene encoding | 2012-05-10 |
20120116059 | Treatment For MTreatment For Multiple Sclerosis - The present invention relates to methods for the treatment and/or prophylaxis of multiple sclerosis (MS). Antagonists of GM-CSF, such as antibodies specific for GM-CSF or the GM-CSF receptor, are effective in the treatment and/or prophylaxis of multiple sclerosis. | 2012-05-10 |
20120116060 | Blockers of NMDA Receptor for the Treatment of Sickle Cell Anemia - Sickle cell anemia is a genetic disease characterized by red blood cells that assume an abnormal, rigid, sickle shape. Acute complications of Sickle cell anemia are treated symptomatically with analgesics and transfusions, and a prophylactic treatment of sickle cell crisis is long term application of hydroxyurea. According to the present invention, an N-methyl D-aspartate receptor (NMDAR) blocker is used for the treatment of sickle cell anemia and for manufacture of a medicament for the treatment of sickle cell anemia. Moreover, a method for screening for a compound effective in the treatment of sickle cell anemia comprises contacting a candidate compound with the NMDAR and selecting said candidate compound as effective if it is found to selectively reduce activity of the NMDAR. | 2012-05-10 |
20120116061 | METHOD OF ARRAYING FERRITIN - A method of selectively arraying ferritin and inorganic particles on a silicon oxide substrate at regions having vanadium, niobium or tantalum. An aspect of the method includes steps of: preparing a solution which contains ferritin modified at an N-terminal part of a subunit with a peptide set out in SEQ ID NO: 1, and from 0.01 v/v % to 10 v/v % of a nonionic surfactant and having a pH of from 7.4 to 8.2; and a binding step of bringing the solution in contact with regions of the substrate having vanadium, niobium, or tantalum to selectively array peptide-modified ferritin to vanadium, niobium or, tantalum portion. The method may also include a step of selectively arraying ferritin modified with the peptide set out in SEQ ID NO: 1, and the inorganic particles contained in ferritin at the vanadium, niobium, or tantalum portion by removing the solution. | 2012-05-10 |
20120116062 | TECHNOLOGY FOR PREPARATION OF MACROMOLECULAR MICROSPHERES - Microspheres are produced by contacting an aqueous solution of a protein or other macromolecule with an organic solvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals of defined dimensions. | 2012-05-10 |
20120116063 | METHODS AND SYSTEMS FOR PROCESSING LIGNOCELLULOSIC MATERIALS AND RELATED COMPOSITIONS - A method comprising: (a) providing a lignocellulosic substrate; (b) contacting said lignocellulosic substrate with an extractant comprising a water-soluble organic solvent to form an extracted substrate and a miscella; (c) removing miscella from said extracted substrate; and (d) hydrolyzing said extracted substrate using a chemically catalyzed process. | 2012-05-10 |
20120116064 | HYBRID LIPID COMPOUNDS BASED ON PENTAERYTHRITOL, INTERMEDIATES, PREPARATION METHODS AND USE THEREOF - This invention relates to a novel class of hybrid lipid compound based on pentaerythritol, their intermediates, preparation methods and uses thereof. Different kinds of functional groups such as alkyl chain, siloxane group, azobenzene, porphyrins, cholesterol, benzene ring and carboxyl were introduced into the four hydroxyl groups of pentaerythritol through chemical reaction to obtain the final hybrid lipid compounds based on pentaerythritol. Cerasomes prepared from such lipids have uniform size, silicate network surface, good stability and biocompatibility, and the leakage of drugs is not easy. The present liposome can be used as functional materials such as drugs or drug carriers, or used for optical storage and molecular devices, simulation, design and synthesis of artificial systems, nano-composite membrane materials and the removal of organic pollutants, etc., in addition, the preparation method of the present invention is simple, and it is easy for industrial production. | 2012-05-10 |
20120116065 | NOVEL METHOD FOR THE SYNTHESIS OF A TRISACCHARIDE - The present invention relates to an improved synthesis of a trisaccharide of the formula, novel intermediates used in the synthesis and the preparation of the intermediates. | 2012-05-10 |
20120116066 | EFFICIENT AND SCALABLE PROCESS FOR THE MANUFACTURE OF FONDAPARINUX SODIUM - The present invention relates to a process for the synthesis of the Factor Xa anticoagulent Fondaparinux and related compounds. The invention relates, in addition, to efficient and scalable processes for the synthesis of various intermediates useful in the synthesis of Fondaparinux and related compounds. | 2012-05-10 |
20120116067 | METHOD FOR THE SOLID PHASE-BASED PRODUCTION OF PHOSPHATE-BRIDGED NUCLEOSIDE CONJUGATES - The invention relates to a method for producing phosphate-bridged nucleoside conjugates. In the method, a cyclosaligenyl nucleotide is produced first, to which a linker is added, which is used to perform the immobilization on a solid phase. A subsequent reaction with corresponding nucleophiles results in the desired phosphate-bridged nucleoside conjugates, which can then again be cleaved from the solid phase-bound linker. | 2012-05-10 |
20120116068 | METHOD FOR BREAKING DOWN CELLULOSE IN SOLUTION - The present invention describes a process for the degradation of cellulose by dissolving the cellulose in an ionic liquid and treating it with an acid, if appropriate with addition of water. | 2012-05-10 |
20120116069 | GLUCOSE METABOLISM-IMPROVING AGENT AND GLUCOSE METABOLISM-IMPROVING COMPOSITION - A sugar metabolism-improving agent including at least one of a compound having a structure expressed by the following Structural Formula (1) and a compound having a structure expressed by the following Structural Formula (2). | 2012-05-10 |
20120116070 | METHOD FOR THE PRODUCTION OF CEFTOBIPROLE MEDOCARIL - The present invention relates to a method for the production of organic compounds, in particular sodium (6R,7R)-7-[(Z)-2-(5-amino-[1,2,4]thiadiazol-3-yl)-2-hydroxyimino-acetylamino]-8-oxo-3-[(E)-(R)-1′-(5-methyl-2-oxo-[1,3]-dioxol-4-ylmethoxycarbonyl)-2-oxo-[1,3′]bipyrrolidinyl-3-ylidenemethyl]-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate (ceftobiprole medocaril), and compounds of the general formula (1) and of the general formula (2), the compounds themselves and intermediates in the production according to the invention. | 2012-05-10 |
20120116071 | Rifaximin - Amorphous rifaximin, methods of making it, and pharmaceutical compositions containing it. Also described are methods of converting amorphous rifaximin to crystalline rifaximin and vice versa. | 2012-05-10 |
20120116072 | NOVEL BENZENESULFONAMIDE COMPOUNDS, METHOD FOR SYNTHESIZING SAME, AND USE THEREOF IN MEDICINE AS WELL AS IN COSMETICS - Benzenesulfonamide compounds having a structure of the following general formula (I) are described. Also described, are methods for synthesizing the compounds, and to the use thereof in pharmaceutical compositions for human or veterinary medicine and in cosmetic compositions. | 2012-05-10 |
20120116073 | P2X4 RECEPTOR ANTAGONIST - A compound having the following formula (II) or its pharmacologically acceptable salt is used as a P2X | 2012-05-10 |
20120116074 | METHODS FOR THE PREPARATION OF [2-(8,9-DIOXO-2,6-DIAZABICYCLO[5.2.0]NON-1(7)-EN-2-YL)ETHYL]PHOSPHONIC ACID AND PRECURSORS THEREOF - The present invention is directed to processes associated with the preparation of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)ethyl]phosphonic acid (perzinfotel). | 2012-05-10 |
20120116075 | Acrylamide Derivative And Use Thereof In Manufacture Of Medicament - An acrylamide derivative represented by formula (I), pharmaceutically acceptable salts and solvates thereof, as well as a medicament containing said acrylamide derivative or its pharmaceutically acceptable salts as the active ingredient, which can be used to treat disorders associated with tyrosine kinase especially Bcr-Abl, including proliferative disorders such as cancers, and inflammation and the like are provided. | 2012-05-10 |
20120116076 | SWITCHABLE SOLVENTS AND METHODS OF USE THEREOF - A solvent that reversibly converts from a nonionic liquid mixture to an ionic liquid upon contact with a selected trigger, e.g., contact with CO | 2012-05-10 |
20120116077 | [1,2,4]THIADIAZIN-3-YL ACETIC ACID COMPOUND[[S]] AND METHODS OF MAKING THE ACETIC ACID COMPOUND - The invention is directed to [1,2,4]thiadiazine 1,1-dioxide compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus. | 2012-05-10 |
20120116078 | PHOSPHORUS-CONTAINING BISPHENOLS AND PREPARING METHOD THEREOF - The Phosphorus-containing bisphenols and preparing method thereof are disclosed. A method for producing the phosphorus-containing bisphenol of the formula (1) includes reacting compounds respectively defined by a formula (a), (b), (c) and an acid catalyst to yield compounds of phosphorus-containing bisphenol. | 2012-05-10 |
20120116079 | PHOSPHONATE FLUORESCENT DYES AND CONJUGATES - Reagents are provided for the introduction of phosphonate groups into fluorescent dyes. Methods are also provided for preparing dye conjugates. | 2012-05-10 |
20120116080 | PROCESS FOR THE STEREOSELECTIVE PREPARATION OF BICYCLIC HETEROCYCLES - The present invention relates to a process for the stereoselective preparation of compounds of general formula (I) | 2012-05-10 |
20120116081 | Process for the Synthesis of 5-(Methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzeneamine - The present invention provides a new method of making compounds of formula (I): | 2012-05-10 |
20120116082 | PROCESS FOR THE PREPARATION OF ROSUVASTATIN SALTS - The present invention relates to a new process for the preparation of rosuvastatin [7-[4-(4-Fluorophenyl)-6-isopropyl-2-(methanesulphonyl-methyl-amino)-pyrimidin-5-yl]-(3R,51S)-dihydroxy-hept-6-enoic acid] of the formula (I) salts formed with bivalent cations, preferably with calcium or zinc ions, characterized in that rosuvastatin tert.-butylammonium salt is reacted with the appropriate bivalent cation, preferably with calcium or zinc ions in a mixture of a water immiscible or slightly miscible organic solvent and water and the formed salt is isolated. | 2012-05-10 |
20120116083 | HETEROAROMATIC PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS - Polyaromatic sodium channel blockers represented by the formula: | 2012-05-10 |
20120116084 | N-TYPE ORGANIC SEMICONDUCTORS INCLUDING AT LEAST TWO 2-DICYANOMETHYLENE-3-CYANO-2,5-DIHYDROFURAN GROUPS - The invention relates to a method for manufacturing transistors. Said method involves using a molecule including at least two 2-dicyanomethylene-3-cyano-2,5-dihydrofuran groups. The invention can be implemented in particular in the field of electronics. | 2012-05-10 |
20120116085 | METHOD FOR THE MANUFACTURING OF NALTREXONE - The present invention relates to an improved process for producing naltrexone[17-(cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxy-morphinan-6-one] from noroxymorphone[4,5-α-epoxy-3,14-dihydroxy-morphinan-6-one] by alkylation with a cyclopropylmethyl halide. | 2012-05-10 |
20120116086 | Sinomenine Derivatives and Processes for their Synthesis - The invention generally provides processes and intermediate compounds useful for the production of sinomenine derivatives. In particular, the process may encompass synthetic routes for the production of (+)-sinomenine derivatives and their intermediates. | 2012-05-10 |
20120116087 | CRYSTALS OF PYRROLOQUINOLINEQUINONE SODIUM SALTS - A crystal of pyrroloquinoline quinone disodium salt having peaks at 2θ of 9.1°, 10.3°, 13.8°, 17.7°, 18.3°, 24.0°, 27.4°, 31.2° and 39.5° (±0.2° for each) in powder X-ray diffractometry using Cu Kα radiation, or a crystal of pyrroloquinoline quinone trisodium salt having peaks at 2θ of 6.6°, 11.4°, 13.0°, 22.6°, 26.9°, 27.9°, 37.0°, 38.9° and 43.4° (±0.2° for each) in powder X-ray diffractometry using Cu Kα radiation. | 2012-05-10 |
20120116088 | 2-[[[2-[(HYDROXYACETYL)AMINO]-4-PYRIDINYL]METHYL]THIO]-N-[4-(TRIFLUOROMETH- OXY)PHENYL]-3-PYRIDINECARBOXAMIDE BENZENESULFONATE, CRYSTAL OF SAME, CRYSTAL POLYMORPH THEREOF, AND METHODS FOR PRODUCTION THEREOF - In the course of developing 2-[[[2-[(hydroxyacetyl)amino]-4-pyridinyl]methyl]thio]-N-[4-(trifluoromethoxy)phenyl]-3-pyridinecarboxamide (compound A), there are the multiple problems: 1) compound A or its salt is difficult to be recrystallized, the storage stability largely differs depending on the kind of the salt, and it is very difficult to obtain a salt of compound A having excellent storage stability; 2) in a crystallization process of compound A, it is very difficult to control a crystal polymorph, and 3) compound A (free body) causes mineral deposition in the stomach when it is orally administered repeatedly. For solving these problems, we made examination focusing on the kind of the salt and, as a result, found that 1) benzenesulfonate of compound A does not decompose by light, humidity and other factors in a 1-week preliminary stability test (severe test), and has no problem in its storage stability, 2) a method of selectively producing two kinds of crystal forms of benzenesulfonate of compound A, and that 3) no mineral deposition in the stomach is observed even after a 4-week repeated oral administration. | 2012-05-10 |
20120116089 | BENZIMIDAZOLE DERIVATIVE - The invention relates to a process for preparing the compound of formula 1, a valuable intermediate product in the synthesis of the pharmaceutical active substance dabigatran etexilate. | 2012-05-10 |
20120116090 | Chiral Diacylhydrazine Ligands for Modulating the Expression of Exogenous Genes via an Ecdysone Receptor Complex - The present invention provides diacylhydrazine ligands and chiral diacylhydrazine ligands for use with ecdysone receptor-based inducible gene expression systems. Thus, the present invention is useful for applications such as gene therapy, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable. An advantage of the present invention is that it provides a means to regulate gene expression and to tailor expression levels to suit the user's requirements. | 2012-05-10 |
20120116091 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS - Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme. | 2012-05-10 |
20120116092 | PROCESS FOR THE PREPARATION OF [1-HYDROXY-2-(1H-IMIDAZOL-1-YL)- ETHYLIDENE] BISPHOSPHONIC ACID - A process for the preparation of [1-hydroxy-2-(1H-imidazol-1-yl)-ethylidene]bisphosphonic acid consists of the reaction of aqueous solution of 1H-imidazole-1-acetic acid hydrochloride with phosphorus trichloride followed by removal of the excess of phosphorus trichloride, addition of water and hydrolysis of the reaction products. In order to isolate the product the post-reaction mixture is filtered and the anti-solvent is added to the aqueous filtrate in order to crystallize out [1-hydroxy-2-(1H-imidazol-1-yl)-ethylidene]bisphosphonic acid monohydrate. | 2012-05-10 |
20120116093 | ONE POT PROCESS FOR PREPARING 2-BUTYL-3-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,3-DIAZASP- IRO [4, 4] NON-1-EN-4-ONE (IRBESARTAN) - A one pot process for the synthesis of Irbesartan comprising reacting 2-n-Butyl-1,3-Diazaspiro[4,4]Non-1-en-4-one (Formula III) and Bromomethyl Cyanobiphenyl (Formula IV) in the presence of base and water with the optional use of PTC to give formula II from which Irbesartan is obtained by reacting with sodium azide and triethylamine hydrochloride in the presence of a non polar solvent. | 2012-05-10 |
20120116094 | COMPOSITIONS COMPRISING AND METHODS FOR FORMING FUNCTIONALIZED CARBON-BASED NANOSTRUCTURES - The present invention generally relates to compositions comprising and methods for forming functionalized carbon-based nanostructures. | 2012-05-10 |
20120116095 | GLYCINE TRANSPORTER INHIBITORS - The present invention aims to provide novel compounds represented by formula [I] or pharmaceutically acceptable salts thereof: | 2012-05-10 |
20120116096 | Method of Dehydrating An Ionic Liquid - A method of impeding water input in an ionic liquid is provided, wherein the method comprises adding an additive to the ionic liquid wherein the additive comprises an orthoester. In particular, at least some residues of the additive may remain or may be present in the ionic liquid during the usage of the ionic liquid. For example, the additive may be formed by the orthoester or by a mixture of orthoesters. | 2012-05-10 |
20120116097 | PROCESS FOR PREPARING HETEROAROMATIC RING COMPOUND HAVING N-Rf GROUP - There is provided a preparation process in which a N—H group of a heteroaromatic ring compound having a N—H group in its ring is converted directly to a N—Rf group at a high reaction efficiency without using a catalyst. The preparation process is a process for preparing a compound comprising a heteroaromatic ring structure having a N—Rf group (—Rf is a fluorine-containing organic group) in its ring and is characterized in that the heteroaromatic ring compound having a N—H group in its ring is allowed to react with fluoroalkene in the absence of an alkali metal. | 2012-05-10 |
20120116098 | SYNTHESIS OF REVERSIBLY PROTECTED SILANES - The present invention discloses a method for synthesizing a reversibly protected organometallic compound which comprises (1) reacting an organometallic compound with a hydroxyl group containing compound to produce a solution containing the reversibly protected organometallic compound and hydrogen chloride; (2) reacting the solution containing the reversibly protected organometallic compound and the hydrogen chloride with a trialkyl amine to precipitate the hydrogen chloride from the solution; and (3) recovering the reversibly protected organometallic compound from the solution of the reversibly protected organometallic compound. | 2012-05-10 |
20120116099 | METHOD OF CONVEYING LIQUIDS - The present invention relates to a method of continuously conveying a liquid which is used as starting material in a chemical reaction by means of a displacement pump having physically separate forward-transport valves and a liquid-filled bidirectional flow line between displacement pump and forward-transport valves, wherein an auxiliary liquid which is a product or a starting material of the chemical reaction and has a melting point which is below the melting point or below the saturation temperature of the liquid to be conveyed is present in the bidirectional flow line. | 2012-05-10 |
20120116100 | SYSTEM AND METHOD FOR PRODUCING POLYHYDROXYCARBOXYLIC ACID - An object of the present invention is to provide a method and a system by which hydroxycarboxylic acid cyclic dimers are efficiently generated, allowing high yields of high-quality polyhydroxycarboxylic acid to be obtained. The method for synthesizing polyhydroxycarboxylic acid comprises a depolymerization step for depolymerizing hydroxycarboxylic acid oligomers to produce hydroxycarboxylic acid cyclic dimers, wherein, in the depolymerization step, a reaction solution is heated via heat transfer from a heat medium passage under reduced pressure while the reaction solution is being flowing through a horizontally provided reaction solution passage. | 2012-05-10 |
20120116101 | METHOD FOR PREPARING DIAHYDROHEXITOL DIESTER COMPOSITIONS - A dianhydrohexitol diester composition is obtained by esterifying a dianhydrohexitol composition with a carboxylic acid in the presence of an acid catalyst and hypophosphorous acid. Preferably, the hypophosphorous acid is introduced in an amount between 0.05 and 2 wt. percent of dianhydrohexitol, and in a hypophosphorous acid/acid catalyst weight ratio of less than 1/1. Dianhydrohexitol diester compositions, for example isosorbide diesters, isomannide and/or isoidide rich in diester(s), and having a low yellow index (YI), are useful in numerous industrial applications, in particular in plastic compositions. | 2012-05-10 |
20120116102 | SILICON-TITANIUM MIXED OXIDE-CONTAINING DISPERSION FOR THE PRODUCTION OF TITANIUM-CONTAINING ZEOLITES - Dispersion containing pyrogenic silicon-titanium mixed oxide powders with a silicon dioxide content of 75 to 99.99 wt.-% and a titanium dioxide content of 0.01 to 25 wt. %, water and a basic, quaternary ammonium compound, wherein the mean aggregate diameter of the particles of the silicon-titanium mixed oxide powder in the dispersion is 200 nm at most. Process for the production of a titanium-containing zeolite with the use of the dispersion. | 2012-05-10 |
20120116103 | Method for Purifying Lipid Material - The present invention relates to a method for purification of lipid material originating from biological material. In the method the lipid material comprising acylglycerols and phosphorus impurities and at least one added nonpolar solvent and at least one added polar solvent is provided into a reaction zone whereby at least a two phase system comprising a nonpolar phase and a polar phase is formed. The phase system is heated in the closed reaction zone under mixing at a temperature from 150° C. to 300° C. and at a pressure wherein said solvents are in subcritical state, preferably of below 100 bar, dependent on the vapor pressure of the selected solvents, until the phosphorus impurity is removed from the polar phase. Sub-sequently, the nonpolar phase including the purified oil comprising acylglycerols is separated and recovered from said phase system. | 2012-05-10 |
20120116104 | MIXTURES OF AND METHODS OF USE FOR POLYUNSATURATED FATTY ACID-CONTAINING PHOSPHOLIPIDS AND ALKYL ETHER PHOSPHOLIPIDS SPECIES - A chemical composition of a molecular species mixture of phospholipids, purified to at least 85% purity through chromatography purification, the chemical composition contains enriched both sn-1-acyl fatty chains/sn-2-docosahexaenoic acid molecular species and sn-1-ether fatty chains/sn-2-docosahexaenoic acid molecular species, the phospholipids are selected from the group consisting of: phosphatidylcholine, phosphatidylserine and phosphatidylethanolamine. Methods using the above disclosed composition in mammals to treat various conditions. | 2012-05-10 |
20120116105 | METHOD FOR RECOVERY OF OIL FROM BIOMASS - A method and apparatus for recovery of lipids from microbial biomass, including providing wet microbial biomass to thermal pretreatment of at least 100° C. in a pressure vessel, subjecting the thermally pretreated microbial biomass to extraction using a liquid hydrocarbon as an extractant, and subsequently, recovering a product containing lipids. | 2012-05-10 |
20120116106 | CO-PRECIPITATED SALTS OF FATTY ACIDS - A co-salt of a polyunsaturated fatty acid and a non-fatty acid is formed as a precipitate. The co-salt formed is free flowing and does not tend to agglomerate (cake) in storage. The resultant co-salt product will be easy to blend with other products to produce dietary supplements. These novel co-salt products may also tablet very well and may be added to current dietary supplement tablets. | 2012-05-10 |
20120116107 | Liquid Fatty Amine Carboxylate Salt Composition - A composition comprising 40 to 90 wt % of at least one fatty amine carboxylate salt, water, and the carboxylic acid corresponding to said carboxylate is provided. In the composition, the weight:weight ratio of carboxylic acid:water is in the range of from 20:1 to 1:1. The inventive compositions have a pour point at a temperature of below 30° C. | 2012-05-10 |
20120116108 | MICROORGANISMS AND METHODS FOR PRODUCING UNSATURATED FATTY ACIDS - Methods of producing an unsaturated free fatty acid comprising at least 18 carbon atoms are provided. In some embodiments, the methods comprise culturing an engineered microorganism in a culture medium, wherein the engineered microorganism comprises at least one recombinant enzyme selected from acyl-lipid desaturase delta-9 (EC:1.14.19.1), acyl-lipid desaturase delta-12 (EC:1.14.19.6), acyl-lipid desaturase delta-15 (EC:1.14.19.-), and thioesterase (EC:3.1.2.14). Engineered microorganisms comprising at least one of those recombinant enzymes are also provided. The methods and organisms can be used to produce at least one free fatty acid selected from oleic acid, linoleic acid and α-linolenic acid. | 2012-05-10 |
20120116109 | PREPARATION OF A METAL COMPLEX - The present invention provides a process for the preparation of a Pd(0)L | 2012-05-10 |
20120116110 | TONER FOR ELECTROPHOTOGRAPHY AND METAL-CONTAINING COMPOUND - Disclosed is a toner for electrophotography, which has good hue, good light resistance and good electrostatic charge, and is capable of providing images that are free from white spots. The toner for electrophotography exhibits a good performance. Specifically disclosed is a toner for electrophotography, which is characterized by containing at least one metal-containing compound that is represented by general formula (1). (In the formula, R1 represents an alkyl group; R2 represents a hydrogen atom, an alkoxycarbonyl group, an aryloxycarbonyl group, a sulfamoyl group, a sulfinyl group, an alkylsulfonyl group, an arylsulfonyl group, an acyl group, a halogen atom or a cyano group; and R3 represents a group that has 9 or more carbon atoms and an aromatic hydrocarbon structure.) | 2012-05-10 |
20120116111 | Process for the preparation of fluoroalkyl (fluoro)alkyl carbonates and carbamates - Fluoroalkyl alkyl carbonates and fluorosubstituted carbamates which are suitable as additives or solvents in lithium ion batteries are prepared from fluoroalkyl fluoroformates and the respective alcohol or amine. Methanol is the preferred alcohol, dimethylamine and diethylamine are preferred amines. Fluoromethyl methyl carbonate is the preferred compound to be produced. Fluoroalkyl fluoroformates can be prepared from aldehydes and carbonyl fluoride. | 2012-05-10 |
20120116112 | PROCESS FOR THE PREPARATION OF FUNCTIONALISED BENZOCYCLOBUTENES, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID - Process for the preparation of compounds of formula (IV): | 2012-05-10 |
20120116113 | PROCESS FOR MAKING NEO-ENRICHED p-MENTHANE COMPOUNDS - A process for making neo-enriched p-menthane intermediates is disclosed. Lewis acid-catalyzed rearrangement of an oxaspiro compound provides an aldehyde mixture comprising normal (II) and neo (III) p-menthane-3-aldehydes: | 2012-05-10 |
20120116114 | PROCESS FOR PRODUCING POLYESTER POLYOLS HAVING SECONDARY OH END GROUPS - The invention relates to a process for producing polyester polyols with secondary hydroxyl end groups, including the step of the reaction of a polyester including carboxyl end groups with an epoxide of the general formula (1): | 2012-05-10 |
20120116115 | Esters with Antimicrobial, Bioresistant and Fungal Resistant Properties - A bromine/nitro moiety linked into the backbone of an ester or other compound over a wide range of occurrence rates provides antimicrobial, bio-resistant and fungal resistant properties for metal working fluids (MWF)s and other coatings. The moiety can be have the bromo and nitro groups linked to the same or different carbon atoms. The present invention also relates to urethanes, urea, amides, imides, carbonates, ethers, siloxanes, and many other types of linkages essential to MWF bases. | 2012-05-10 |
20120116116 | METHOD FOR MANUFACTURING SPILANTHOL AND INTERMEDIATE MANUFACTURING PRODUCT THEREFOR - Provided is an amide ester that is useful as an intermediate manufacturing product for an aroma compound such as spilanthol or the like. Also provided is a spilanthol manufacturing method using said amide ester. High-purity spilanthol can be manufactured by reacting an amide ester represented by general formula (1) with a basic compound. | 2012-05-10 |
20120116117 | PROCESS FOR THE PREPARATION OF MELPHALAN HYDROCHLORIDE - The present invention provides a simple and efficient method for synthesis of 4-[bis (2-chloroethyl)-amino]-L-phenylalanine hydrochloride. The process involves the treatment of 4-[bis(2-chloroethyl)-amino]-L-phenylalanine free base with hydrochloric acid in water followed by isolation of 4-[bis(2-chloroethyl)-amino]-phenylalanine hydrochloride of desired purity. | 2012-05-10 |
20120116118 | Method for Producing (2,4-Dimethylbiphenyl-3-yl)Acetic Acids, the Esters Thereof and Intermediate Compounds - The present invention relates to a novel process for preparing substituted and unsubstituted (2,4-dimethylbiphenyl-3-yl)acetic acids and their esters of the formula (I) using homogeneous and heterogeneous palladium catalysts, and also the intermediates 4-tert-butyl-2,6-dimethylphenylacetic acid and 4-tert-butyl-2,6-dimethylmandelic acid, and to processes for their preparation. | 2012-05-10 |
20120116119 | PRODUCTION OF 2,4-HEXADIENOIC ACID AND 1,3-PENTADIENE FROM 6-METHYL-5,6-DIHYDRO-2-PYRONE - Described is a method of making sorbic acid, pentadiene, or 3-penten-2-one. The method includes partially hydrogenating 4-hydroxy-6-methyl-2-pyrone (HMP) to yield 5,6-dihydro-4-hydroxy-6-methyl-2H-pyran-2-one (4-DHMMP). Then, if 3-penten-2-one is desired, thermally decomposing the 4-DHMMP to yield 3-penten-2-one. If sorbic acid or pentadiene are desired, the 4-DHMMP is hydrogenated to yield 4-hydroxy-6-methyltetrahydro-2-pyrone (4-HMTHP). The 4-HMTHP is then dehydrated by contacting it with a solid acid catalyst to yield parasorbic acid (PSA). The PSA can then be ring-opened by contacting it with a solid acid catalyst. The reaction conditions of the ring-opening reaction can be controlled to yield sorbic acid and/or pentadiene. | 2012-05-10 |
20120116120 | Pyrolysis Reactor Conversion of Hydrocarbon Feedstocks Into Higher Value Hydrocarbons - In one aspect, the inventive process comprises a process for pyrolyzing a hydrocarbon feedstock containing nonvolatiles in a regenerative pyrolysis reactor system. The inventive process comprises: (a) heating the nonvolatile-containing hydrocarbon feedstock upstream of a regenerative pyrolysis reactor system to a temperature sufficient to form a vapor phase that is essentially free of nonvolatiles and a liquid phase containing the nonvolatiles; (b) separating said vapor phase from said liquid phase; (c) feeding the separated vapor phase to the pyrolysis reactor system; and (d) converting the separated vapor phase in said pyrolysis reactor system to form a pyrolysis product. | 2012-05-10 |
20120116121 | PROCESS FOR THE SULFOCHLORINATION OF HYDROCARBONS - Produce a sulfo-chlorinated hydrocarbon using liquid sulfur dioxide, a chlorinating agent such as chlorine or sulfuryl chloride, and a metal complex catalyst, the catalyst being represented as LnM where L is at least one of an amine, phosphine, chloride or oxide, n is an integer within a range of from 1 to 6, and M is a metal selected from a group consisting of copper (Cu), ruthenium (Ru), iron (Fe), chromium (Cr), lanthanum (La), nickel (Ni), palladium (Pd), rhodium (Rh), rhenium (Re), molybdenum (Mo) and manganese (Mn). | 2012-05-10 |