19th week of 2019 patent applcation highlights part 13 |
Patent application number | Title | Published |
20190134223 | METHODS AND COMPOSITIONS FOR TREATING HEART FAILURE - This invention is generally related to novel compositions for treating or preventing heart failure. Specifically, the disclosure provides a composition comprising an amino-terminal domain of Beta.adrenergic receptor kinase-1 (Beta.ARKnt) peptide, or a nucleic acid encoding Beta.ARKnt. Further disclosed are methods of using the compositions for treating or preventing heart failure in a subject or for altering Beta.-adrenergic receptor (Beta.AR) density in a subject. | 2019-05-09 |
20190134224 | DIET CONTROLLED EXPRESSION OF A NUCLEIC ACID ENCODING A PRO-APOPTOTIC PROTEIN - A nucleic acid for the controlled expression of a nucleic acid encoding a pro-apoptotic protein in an individual, including: a regulatory polynucleotide including a minimal promoter and at least one AARE (amino acid response element) nucleic acid, the regulatory polynucleotide being activated in an individual upon consumption of a diet deficient in at least one essential amino acid; and a nucleic acid encoding a pro-apoptotic protein, which is placed under the control of the regulatory polynucleotide. | 2019-05-09 |
20190134225 | INTRATHECAL DELIVERY OF RECOMBINANT ADENO-ASSOCIATED VIRUS 9 - The present invention relates to Adeno-associated virus type 9 methods and materials useful for intrathecal delivery of polynucleotides. Use of the methods and materials is indicated, for example, for treatment of lower motor neuron diseases such as SMA and ALS as well as Pompe disease and lysosomal storage disorders. It is disclosed that administration of a non-ionic, low-osmolar contrast agent, together with a rAA9 vector for the expression of Survival Motor Neuron protein, improves the survival of SMN mutant mice as compared to the administration of the expression vector alone. | 2019-05-09 |
20190134226 | INTRATHECAL DELIVERY OF RECOMBINANT ADENO-ASSOCIATED VIRUS 9 - The present invention relates to Adeno-associated virus type 9 methods and materials useful for intrathecal delivery of polynucleotides. Use of the methods and materials is indicated, for example, for treatment of lower motor neuron diseases such as SMA and ALS as well as Pompe disease and lysosomal storage disorders. It is disclosed that administration of a non-ionic, low-osmolar contrast agent, together with a rAA9 vector for the expression of Survival Motor Neuron protein, improves the survival of SMN mutant mice as compared to the administration of the expression vector alone. | 2019-05-09 |
20190134228 | System and Method for Managing All Cancers by Disabling the Cancer Cells Ability to Reproduce - This invention provides tools and methods that prevent a cancer cell from growing and reproducing more cancer cells. When growth ceases the body's immune defenses are enabled to attack and destroy these cells if the cancer cell itself has not initiated its own natural apoptotic self-destruction processes. The tools and methods of the invention obstruct the metabolic adaptions required to support cancer growth. By addressing the increased rates of metabolism characteristic of all rapidly reproducing cancer cells using chemical and/or physical nanotechnology to identify, segregate, isolate these hypermetabolizing cells, the body's immune system and other natural defenses are empowered to further isolate and eliminate the diseased cells. The extreme growth rates required for their rapid reproduction involve massively increased rates of the biochemical reactions supporting the cancerous growth. Each excess reaction produces extra heat and raises the internal cell's temperature and the tissue space immediate to the rapidly growing cells. This heat signature is used as a primary biomarker that enables binding of a nanoviral particle engineered to migrate to at attach at the target site at the site and prevent the cell from continued metabolism. Preferably, the nanoparticle not only binds and blocks external membrane receptors on the target cell, but incorporates into the rapidly metabolizing cells additional metabolic blocking agents to stop their growth. When cell growth and proliferation are stopped, the body's natural defenses are able to segregate and eliminate these cells. The massively increased rates of metabolic reactions characteristic of cancer cells also produce excess acid. The decreased pH is useful as a secondary or confirmatory marker for identifying these cancer cells. | 2019-05-09 |
20190134229 | METHOD OF IDENTIFYING ASD PHENOTYPE 1 PATIENTS - The present invention is directed to a method of identifying autism spectrum disorder (ASD) phenotype 1 patients, wherein the method comprises: administering an Nrf2-activator to an ASD patient previously diagnosed with idiopathic ASD or a subject displaying clinical signs of ASD, and identifying the ASD patient as an ASD phenotype 1 patient if the patient shows a negative response after administration of the Nrf2-activator. Likewise, the present invention is directed to a method for classifying autism spectrum disorder (ASD) phenotype 1 patients, the method comprising: administering an Nrf2-activator to a subject, and observing if the subject shows a negative response after administration of the Nrf2-activator, in which the subject is a patient previously diagnosed with idiopathic ASD or a subject displaying clinical signs of ASD and in which the negative response supports classification of the subject as an ASD phenotype 1 patient. | 2019-05-09 |
20190134230 | CHALLENGE TEST FOR DIAGNOSING SUBTYPES OF ASD - The present invention is directed to a method for differentiating between ASD phenotype 1, phenotype 2 and other ASD patients, wherein the method comprises,: administering an Nrf2-activator to a subject, and identifying the subject as an ASD phenotype 1 patient if the subject shows a negative response, as a phenotype 2 patient if he shows a positive response and as another ASD patient if he does not show a positive nor a negative response, wherein the subject is a patient previously diagnosed with idiopathic ASD or a subject displaying clinical signs of ASD. Likewise, the present invention is directed to an Nrf2-activator for use in differentiating between autism spectrum disorder (ASD) phenotype 1 patients, phenotype 2 patients and other ASD patients, wherein the Nrf2-activator is administered to a subject, wherein a phenotype 1 patient is identified by a negative response, a phenotype 2 patient is identified by a positive response and other ASD patients are identified by the absence of a positive and a negative wherein the subject is a patient previously diagnosed with idiopathic ASD or a subject displaying clinical signs of ASD. | 2019-05-09 |
20190134231 | METHODS AND COMPOSITIONS FOR DETECTING ANEURYSMS - Provided herein are methods and compositions for the detection of vulnerable, rupture-prone aneurysms using multi-meric folate conjugated peptides (FCPs). Further provided are methods for treating aneurysms identified to be at risk of rupture. | 2019-05-09 |
20190134232 | RADIOLIGANDS FOR MYELIN - A radioligand for labeling myelin includes a fluorescent trans-stilbene derivative. | 2019-05-09 |
20190134233 | COMPOSITIONS AND METHODS FOR AL AMYLOID DETECTION AND USES THEREOF - Among the various aspects of the present disclosure is the provision of compositions and methods for imaging and treating subjects with amyloidosis or multiple myeloma with or without amyloidosis. | 2019-05-09 |
20190134234 | COMPOSITION FOR STABILIZING RADIOCHEMICAL PURITY OF [18F] FLUORO-DOPA AND METHOD FOR PREPARING SAME - The present disclosure relates to a composition for stabilizing the radiochemical purity of [ | 2019-05-09 |
20190134235 | 18F-FNDP FOR PET IMAGING OF SOLUBLE EPOXIDE HYDROLASE (sEH) - Radiofluorinated FNDP for PET imaging of soluble epoxide hydrolase (sEH) and method of using the same are disclosed. | 2019-05-09 |
20190134236 | CONJUGATES FOR IMAGING - The invention described herein relates to conjugates and compositions for imaging, diagnosing, and/or monitoring diseases using radionuclide-based imaging. In particular, the invention described herein relates to conjugates and compositions for imaging, diagnosing, and/or monitoring diseases using positron emission tomography. | 2019-05-09 |
20190134237 | TRIAZINE BASED RADIOPHARMACEUTICALS AND RADIOIMAGING AGENTS - Metal complexes including a radionuclide and a compound of Formula I and Formula II are potent inhibitors of PSMA. | 2019-05-09 |
20190134238 | SN-117M LABELED MANNOSE COUPLED DEXTRAN AMINE - Amine modified dextran is labeled with mannose molecules as well as tin-117m. This tin-117m labeled mannose modified dextran is useful in treating maladies that express CD206, in particular rheumatoid arthritis, as well as the cancer typically located in the lymph nodes. This provides a systemic treatment for such maladies. The tin-117m will destroy cells to which it is bonded and also can be imaged. Further, due to the nature of the radiation from the tin-117m, it does not do significant damage to nearby healthy cells. | 2019-05-09 |
20190134239 | PRE-TARGETING STRATEGIES FOR MOLECULAR IMAGING AND/OR RADIOIMMUNOTHERAPY - The present invention provides a method of targeted molecular imaging and/or targeted drug delivery, wherein two components or probes each interacts with one or more biomarkers on a cell and separately interact with each other to form a stable bond, such as a stable covalent bond. In certain non-limiting embodiments, at least one of the probes is photo-triggered to allow for bonding with at least one second probe. In certain non-limiting embodiments, the cell is a tumor or cancer cell. The present invention also relates to compounds, probes, and kits for use in targeted molecular imaging and/or targeted drug delivery. | 2019-05-09 |
20190134240 | DIMERIZATION STRATEGIES AND COMPOUNDS FOR MOLECULAR IMAGING AND/OR RADIOIMMUNOTHERAPY - The present invention provides a multivalent compound for targeted molecular imaging and/or targeted drug delivery, wherein two components or targeting molecules each interacts with one or more biomarkers on a cell. The present invention further provides a multifunctional chelator to combine the targeting molecules. The present invention also provides an in vitro high-throughput screening assay to determine the length of the spacer molecules. The present invention also relates to compounds/probes, kits and methods for use in targeted molecular imaging and/or targeted drug delivery. | 2019-05-09 |
20190134241 | NOZZLE-TYPE ELECTRON BEAM IRRADIATION DEVICE, AND ELECTRON BEAM STERILIZATION EQUIPMENT EQUIPPED WITH SAME - A nozzle-type electron beam irradiation device includes a vacuum chamber, an electron beam generator disposed in the vacuum chamber, and a vacuum nozzle that is connected to the vacuum chamber so as to guide an electron beam from the electron beam generator and emit the electron beam to the outside. The nozzle-type electron beam irradiation device includes a high-vacuum pump capable of sucking gas from the vicinity of the connecting part of the vacuum nozzle in the vacuum chamber. | 2019-05-09 |
20190134242 | SYSTEMS AND METHODS FOR DISINFECTION - A disinfecting system includes a housing. An ultraviolet light (UV) source is secured to the housing and configured to emit UV light for disinfection of a target. A processor is secured to the housing in communication with the UV light source. The processor is configured to activate the UV light source for a selected amount of time suitable for disinfection of the target. | 2019-05-09 |
20190134243 | PLASMA STERILIZATION SYSTEM AND METHODS - A system and methods for sterilizing or disinfecting articles, particularly the hollow internal areas of medical instruments are disclosed. The system includes a plasma generator having an electrode, a shield, and a dielectric gap between the electrode and the shield. A source of electrical power is connected to the plasma generator for applying an electron energy density between the electrode and the shield. A source of gas comprising water vapor, oxygen and nitrogen provides a flow of gas between the electrode and the shield, to form a plasma containing acidic and/or oxidizing species. In the exemplary system, the temperature at the shield's surface is <150° C. when the electron energy density is >0.05 eV/molecule of the gas. Also disclosed is a method for disinfecting an article contaminated with a bio-film or spores, by exposing the contaminated article to the plasma for an exposure time sufficient to achieve at least 2-log | 2019-05-09 |
20190134244 | METHOD OF LIMITING THE SPREAD OF NOROVIRUS WITHIN A CRUISE SHIP - A method of limiting the spread of the norovirus within a cruise ship comprising: identifying a surface within a common area of a cruise ship that passengers are likely to touch; and applying a silane quaternary ammonium ion or salt thereof to the surface. The common area can be an elevator and the surface an elevator button. The common area can be a stairway and the surface a handrail. The common area can be a casino. The common area can be a dining room. The common area can be a walkway and the surface a handrail. The silane quaternary ammonium ion or salt thereof can be 3-(trimethoxysilyl)propyldimethyloctadecyl ammonium ion, 3-(trimethoxysilyl)propyldimethyloctadecyl ammonium chloride, 3-(trihydroxysilyl)propyldimethyloctadecyl ammonium ion, or 3-(trihydroxysilyl)propyldimethyloctadecyl ammonium chloride. Applying the silane quaternary ammonium ion or salt thereof to the surface comprises applying a solution including the silane quaternary ammonium ion or salt thereof and a solvent. | 2019-05-09 |
20190134245 | Apparatus and Method for Reducing Malodor on Surfaces - A method of reducing malodor on surfaces including providing an apparatus in an environment including a surface wherein the surface has a malodor containing compound selected from: amine-containing compound and thiol-containing compound. The apparatus includes a volatile material having a volatile carbonyl containing compound. The volatile material is exposed to the environment such that the volatile carbonyl containing compound vaporises and deposits on the surface. The carbonyl containing compound undergoes a nucleophilic addition in the presence of the malodor containing compound. | 2019-05-09 |
20190134246 | RECHARGEABLE, MICRO-DIFFUSER APPARATUS AND METHOD - A rechargeable, micro-diffuser apparatus and method provide a housing having a cage to hold an absorbent solid. The cage may include slots admitting air over absorbent beads. An aromatic liquid may drip or pour through an opening to the beads, which then absorb or adsorb that liquid. Ambient air evaporates or otherwise diffuses the aromatic liquid as aromatic vapor into surrounding air. The apparatus operates with no open container of bulk liquid, but only interstitially held liquid within polymeric molecules of absorbent beads or spread over an adsorbent surface. | 2019-05-09 |
20190134247 | FAN WITH AIR FRESHENING DISPENSER - The fan with air freshening dispenser comprises a fan operated by an electrical motor, which dispenses a scent from an air freshener located at the front center of the fan. The air freshener is held within an air freshener compartment, which may be opened to replenish the air freshener. The fan comprises a stand suitable for use on a support surface, such as a desk or table, or on the floor. The fan with air freshening dispenser comprises an electronics unit, which provides clock, alarm, and timer functions. A remote control allows the fan with air freshening dispenser to be operated from a distance. | 2019-05-09 |
20190134248 | METHOD AND APPARATUS FOR DISINFECTION - A process and apparatus for disinfection of spaces using a disinfecting liquid droplet spray atomization are described, in which an electric fan | 2019-05-09 |
20190134249 | Method and Apparatus for Rapid Sterilization of Building Air - Methods and systems for rapid sterilization of building air are disclosed, including using a UV source to generate a UV light within an interior volume of duct work of an air handling system; and absorbing the UV light to sterilize. Other embodiments are described and claimed. | 2019-05-09 |
20190134250 | PHOTOCATALYTIC AIR TREATMENT SYSTEM AND METHOD - A photocatalytic air treatment system, including apparatuses and methods, for killing and/or mineralizing bacteria, viruses, mold, fungi, spores, mycotoxins, allergens, and other similar microorganisms or agents, and for oxidizing volatile organic compounds (VOCs). The system comprises one or more reactor beds configured in one or more stages with each reactor bed including a plurality of photocatalyst coated media substantially surrounding a plurality of sheathed ultraviolet light sources that may be arranged in a plurality of configurations. Adjacent ultraviolet light sources are positioned so as to create killing zones of photocatalyst coated media therebetween that are irradiated with ultraviolet light from multiple sources and in which an increased number of hydroxyl radicals are present. The photocatalyst generally comprises titanium dioxide, but may include one or more enhancers. The media is formed from or is coated with a material that induces the photocatalyst to form a nano-particle structure. | 2019-05-09 |
20190134251 | DEODORIZATION MODULE AND STORAGE APPARATUS COMPRISING SAME - A deodorization module and a storage apparatus, the deodorization module including: a housing having one surface including a curved surface; a suction port formed on one surface of the housing to draw in external air; a fan disposed in the suction port and drawing in air; a discharge port formed on one surface of the housing to discharge the air drawn through the fan into the outside of the housing; a photocatalytic filter disposed between the fan and the discharge port and including a through hole through which air passes; and a light source module for irradiating ultraviolet rays onto the photocatalytic filter. | 2019-05-09 |
20190134252 | DRESSINGS COMPRISING PLATELET LYSATE - A dressing comprises a delivery vehicle and platelet lysate. The dressing can also include an antimicrobial agent, a hemostatic agent, and a binder. It is contemplated that the dressing can be used for expediting hemostasis, improving antimicrobial activity, minimizing fluid loss, and accelerating wound healing when applied to a wound. The dressing would be useful in applications including military in-theater medical care and for conditions such as diabetic foot ulcers, as well as other applications. | 2019-05-09 |
20190134253 | WOUND MANAGEMENT SYSTEM AND METHODS OF USING - A wound management system can comprise a surgically acceptable adhesive disposed over a wound and a surgically acceptable film repositionably disposed over the surgically acceptable adhesive, and methods of managing a wound involving the same. | 2019-05-09 |
20190134254 | WATER-VAPOR-PERMEABLE ADHESIVE BANDAGES - The present invention relates to adhesive bandages provided with a water-vapor permeable back layer and an adhesive layer, in which the adhesive layer includes 10 weight percent of a disperse internal phase of hydrophilic particles that are water-swellable in an outer phase that includes at least 10 weight percent of a styrene block copolymer and at least 20 weight percent of an ester resin of colophony, and that can further contain at least one anti-virus substance. | 2019-05-09 |
20190134255 | SILICONE FREE PRODUCTS WITH EQUIVALENT ADHESION AND SILICONE-LIKE LOW TRAUMA SKIN CONTACT PROPERTIES - This technology relates to silicone-free gel adhesives with advanced skin properties for low trauma applications. These gel adhesive products provide the benefits of silicone products while improving on the major disadvantages of silicone adhesive products such as being more cost-effective and gamma sterilizable. The adhesives for this technology may be solvent acrylic, hot melt acrylics or modified block rubbers. | 2019-05-09 |
20190134256 | AN ADHESIVE WAFER WITH A NEUTRALIZER MATRIX - An adhesive wafer ( | 2019-05-09 |
20190134257 | POLYMER PARTICLES - Biodegradable, cross-linked polymer particle embolics and methods of making the same are described. The particle embolics can be used as embolization agents. | 2019-05-09 |
20190134258 | HEMOSTATIC PASTE HAVING SURFACE ENRICHED WITH HEMOSTASIS-PROMOTING AGENTS AND DEVICES FOR DELIVERY - The present invention is directed to a hemostatic semi-solid paste material comprising a bioabsorbable carrier hemostatic material; and a supplemental hemostatic agent; wherein the paste material has an elongated form extending along a lengthwise axis with an aspect ratio of at least 3; wherein the paste is self-supporting and syringe extrudable; and wherein the supplemental hemostatic agent has a non-homogenous distribution profile across a cross-section taken across the lengthwise axis. In another aspect, the present invention relates to devices for forming and expressing the hemostatic material. | 2019-05-09 |
20190134259 | INTRAOPERATIVE USES OF SETTABLE SURGICAL COMPOSITIONS - Provided herein are settable surgical compositions and methods for their intraoperative use. | 2019-05-09 |
20190134260 | SHEET-LIKE HEMOSTATIC MATERIAL EMPLOYING POLY-GAMMA-GLUTAMIC ACID, AND METHOD OF MANUFACTURING SAME - A sheet-like hemostatic material is provided with: an adhesive layer which serves as an affixing surface to a bleeding site and which is formed from at least poly-γ-glutamic acid (γ-PGA); and a covering layer which is a sheet formed from at least one biodegradable material (covering material) other than γ-PGA, and which serves as an opposite surface to the affixing surface. At least one of the adhesive layer and the covering layer is a single sheet. If the adhesive layer is a single sheet, the adhesive layer should be a sponge-like sheet, and if the adhesive layer is a partial layer, the adhesive layer should be a sponge-like sheet or a nonporous layer. Alternatively, in another sheet-like hemostatic material, a sheet which is formed from at least poly-γ-glutamic acid (γ-PGA) and to which at least one of a saccharide and collagen has been added is provided as the adhesive layer. | 2019-05-09 |
20190134261 | PHOSPHOCALCIC CEMENT COMPOSITION COMPRISING BLOOD - A bone cement paste containing a powder component comprising α-tricalcium phosphate (α-TCP) particles having an average size greater than or equal to 9 μm, and a liquid component comprising blood is disclosed. A method for preparation of the phosphocalcic cement composition is also disclosed. | 2019-05-09 |
20190134262 | Bioactive Glass-Polymer Composite Bone Scaffolds - Disclosed herein is a technology for healing bone defects using bioactive silicate glass (BSG) and a 3D osteomimetic composite porous scaffold containing microspheres comprised of poly(lactide-co-glycolide) (PLGA). | 2019-05-09 |
20190134263 | System and Method for Vascularized Biomimetic 3-D tissue Models - The present invention relates to a vascularized three dimensional construct for thick tissue, a process for making the construct and to the use of the construct in tissue regeneration and repair and in drug development. The three-dimensional (3-D) tissue technology is used to generate vascularized, biomimetic tissue models in vitro utilizing a biodegradable nanofiber scaffold. The culture system allows the maintenance of long-term survival and function of liver and heart cells. The system utilizes a novel approach to generate structures that mimic in vivo tissue architecture. The system provides a microenvironment for forming 3-D microvascular networks within the nanofiber scaffolds. | 2019-05-09 |
20190134264 | TISSUE STRUCTURE SCAFFOLDS - A method of forming a scaffold comprises the steps of: preparing a high internal phase emulsion (HIPE) comprising an aqueous solution of: proteins selected from the group consisting of collagen and mixtures of collagen and chitosan; and a cross-linking agent; by addition of an immiscible solvent to the solution to form the HIPE; reducing the temperature of the HIPE to solidify the HIPE; removing water and solvent by vaporisation at a temperature above the melting point of the solvent to form a porous structure; and before or after removal of solvent, causing cross-linking of the protein with the cross-linking agent to form a crosslinked scaffold structure. | 2019-05-09 |
20190134265 | TISSUE-DERIVED TISSUEGENIC IMPLANTS, AND METHODS OF FABRICATING AND USING SAME - The disclosure provides implants containing a plurality of particles containing at least one population of viable cells adherent to and resident in soft tissue matrix or at least one viable population of cells caused to be in contact with the soft tissue matrix; methods of fabricating the implants; and use of the implants in tissue repair. | 2019-05-09 |
20190134266 | Prosthetic Tissue Valves and Methods for Replacing Native Atrioventricular Valves with Same - A percutaneous transseptal surgical implantation method for replacing a defective atrioventricular (AV) valve with a conical shaped prosthetic valve formed from extracellular matrix (ECM) tissue. When the method is employed to replace a native mitral valve, the method positions the prosthetic tissue valve in the mitral valve region, whereby the valve does not obstruct the outflow tract of the aortic valve and prevents the leaflets of the aortic valve from coapting. | 2019-05-09 |
20190134267 | BIOPOLYMER SCAFFOLD IMPLANTS AND METHODS FOR THEIR PRODUCTION - Compositions and blends of biopolymers and bio-acceptable polymers are described, along with the use of benign solvent systems to prepare biocompatible scaffolds and surgically implantable devices for use in supporting and facilitating the repair of soft tissue injuries. | 2019-05-09 |
20190134268 | MEMBRANOUS TISSUE WITH EVENLY SPACED ELEVATED PROJECTIONS ON ONE SIDE AND CONCAVE DEPRESSIONS ON THE OTHER SIDE METHOD AND USE - The present invention discloses the method of preparation and use of soft tissue membranous structures into slip resistant membranes with regularly spaced surface projections on one side and concave depressions on the other side with perforations or without perforations which enhance vascular ingrowth and tissue incorporation. | 2019-05-09 |
20190134269 | INDIRECT METHOD OF ARTICULAR TISSUE REPAIR - Methods and devices for the repair of a torn or injured ligament or tendon are provided. The methods include the use of multiple scaffolds, e.g., beads. The multiple scaffolds may be positioned along a suture or other device such that they are moveable with respect to one another or the injured tissue. | 2019-05-09 |
20190134270 | DEVICE AND PROCESS FOR PRODUCING FIBER PRODUCTS AND FIBER PRODUCTS PRODUCED THEREBY - The present invention is directed to a fiber, preferably bone fiber, having a textured surface, which acts as an effective binding substrate for bone-forming cells and for the induction or promotion of new bone growth by bone-forming cells, which bind to the fiber. Methods of using the bone fibers to induce or promote new bone growth and bone material compositions comprising the bone fibers are also described. The invention further relates to a substrate cutter device and cutter, which are effective in producing substrate fibers, such as bone fibers. | 2019-05-09 |
20190134271 | YARN FOR CELL CULTURE SCAFFOLD, AND FABRIC INCLUDING THE SAME FOR CELL CULTURE SCAFFOLD - Provided is yarn for a cell culture scaffold. The yarn includes ply-twisted fiber strands, and to prevent density-dependent inhibition of cultured cells and increase a cell-contacting specific surface area, at least a part of the plurality of twisted fiber strands are untwisted such that an open space is formed between the fibers. A cell proliferation rate and cell viability may be increased by creating microenvironments suitable for migration, proliferation and differentiation of the cultured cells using the yarn. A large quantity of cells may be simultaneously cultured by creating a cell proliferation space as large as possible in a scaffold space having a limited cell proliferation space, and cell proliferation may be steadily maintained by preventing the inhibition of cell proliferation due to intercellular contact. The cells cultured may be cultured to have a shape/structure suitable for application to an in vitro experiment model or implantation into an animal body. | 2019-05-09 |
20190134272 | Hybrid Implant Made of a Composite Material - The present invention relates to a (poly)hybrid implant made of one or more composite materials, having a polymer matrix and a ceramic-inorganic and/or inorganic component, wherein the polymer matrix has at least one component, selected from the group PDLLA; PLGA, PCL, HDPE, PE, UHMWPE, PEAK, PEEK, PP, PUR, and the ceramic-inorganic component has at least one calcium-phosphate-based component, preferably selected from the group HAP, α-TCP, β-TCP and CaCO | 2019-05-09 |
20190134273 | HIGH TEMPERATURE MELTING - The present invention relates to methods for making wear and oxidation resistant polymeric materials by high temperature melting. The invention also provides methods of making medical implants containing cross-linked antioxidant-containing tough and ductile polymers and materials used therewith also are provided. | 2019-05-09 |
20190134274 | ENGINEERING MULTILEVEL CELL SHEET-DERIVED BLOOD VESSELS - Engineered multilevel cell sheet-derived blood vessels and methods of preparing and using them are disclosed. Blood vessels are generated by wrapping cell sheets around a rod-like device, such as an angiocath needle, to form a tube, which is stabilized with a cyanoacrylate membrane or fibrin glue followed by endothelialization. Such engineered blood vessels can be implanted in tissue and used in vascular surgery as vascular bypass or interposition grafts as well as for vascularization and perfusion of tissue or organs prior to transplant. | 2019-05-09 |
20190134275 | HYALURONIC ACID-BASED GELS INCLUDING LIDOCAINE - Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and pharmaceutically acceptable salts thereof. In one aspect, hyaluronic acid-based compositions described herein include a therapeutically effective amount of at least one anesthetic agent, for example, lidocaine. The present hyaluronic acid-based compositions including lidocaine have an enhanced stability and cohesivity, relative to conventional compositions including lidocaine, for example when subjected to sterilization techniques or when stored for long periods of time. Methods and processes of preparing such hyaluronic acid-based compositions are also provided. | 2019-05-09 |
20190134276 | THREE DIMENSIONAL POROUS CARTILAGE TEMPLATE - This application relates to biologically compatible porous cartilage templates for in vitro and in vivo generation of bone with enhanced structural characteristics. Provided herein are compositions having an internal structure desirable for the generation and regeneration of bone, along with methods of preparation and use. | 2019-05-09 |
20190134277 | ANTI-INFLAMMATORY COATINGS TO IMPROVE BIOCOMPATIBILITY OF NEUROLOGICAL IMPLANTS - Neurological implants whose surfaces have been chemically and covalently modified to impart beneficial properties to the neurological implants are described. The neurological implants possess improved biocompatibility compared to a corresponding neurological implant that lacks the chemical modification. Following implantation in a subject, the surface-modified neurological implants induce a lower-foreign body response, compared to a corresponding unmodified product. | 2019-05-09 |
20190134278 | Apparatus And Method For Identifying Alternative Cell Chemistries For Batteries - New and useful systems, methods, and apparatuses for automatically identifying alternative cell chemistries of batteries that power portable electric devices and adjusting the characteristics of such devices in response to the identification of such cells in a reduced-pressure therapy environment are set forth in the appended claims. | 2019-05-09 |
20190134279 | ARTHROSCOPIC DEVICES AND METHODS - A fluid management system includes a pump connectable to a fluid source. An inflow line removably connects to a cannula for delivering a fluid flow from the pump into a surgical site, such as a joint cavity. A flow pressure sensor is coupled to measure flow pressure in the inflow line and produce a measured pressure value, A controller is connected to the pump and the flow pressure sensor, and the controller maintains a pressure set point by controlling a pump speed based on a backpressure-adjusted pressure value calculated by subtracting a backpressure value selected from a backpressure table from the measured pressure value. The BAPV is monitored to determine whether the BAPV deviates outside an initial BAPV range, and corrective measure are taken should such deviations occur. | 2019-05-09 |
20190134280 | INTEGRATED SYSTEM FOR ASSESSING WOUND EXUDATES - An integrated system for assessing wound exudates from the wound of a patient is described. The system may contain functionality to detect, process and report various wound parameters. The system also may make treatment determinations based on these findings. The system may detect one or more physiological values of the wound exudates from the wound of the patient. The system may means for comparing the one or more detected physiological values to predetermined physiological values in order to obtain a comparison result in real time. The system may include a processor | 2019-05-09 |
20190134281 | Foot Pedal Occlusion Indicator System, Apparatus, and Method - A system, method and apparatus for notifying a surgeon of an occlusion in an ocular surgical apparatus are disclosed herein. Through operation of a handpiece of the surgical apparatus, the handpiece may become blocked or occluded. An occlusion detector is configured to sense the occlusion in the handpiece, and an occlusion signal is generated. A control module is provided to send an occlusion warning signal to a foot pedal of the surgical apparatus, where a tactile notification is provided to a user of the apparatus that an occlusion has occurred. | 2019-05-09 |
20190134282 | Foot Pedal Occlusion Indicator System, Apparatus, and Method - A system, method and apparatus for notifying a surgeon of an occlusion in an ocular surgical apparatus are disclosed herein. Through operation of a handpiece of the surgical apparatus, the handpiece may become blocked or occluded. An occlusion detector is configured to sense the occlusion in the handpiece, and an occlusion signal is generated. A control module is provided to send an occlusion warning signal to a foot pedal of the surgical apparatus, where a tactile notification is provided to a user of the apparatus that an occlusion has occurred. | 2019-05-09 |
20190134283 | Foot Pedal Occlusion Indicator System, Apparatus, and Method - A system, method and apparatus for notifying a surgeon of an occlusion in an ocular surgical apparatus are disclosed herein. Through operation of a handpiece of the surgical apparatus, the handpiece may become blocked or occluded. An occlusion detector is configured to sense the occlusion in the handpiece, and an occlusion signal is generated. A control module is provided to send an occlusion warning signal to a foot pedal of the surgical apparatus, where a tactile notification is provided to a user of the apparatus that an occlusion has occurred. | 2019-05-09 |
20190134284 | NEGATIVE PRESSURE WOUND THERAPY DEVICE - A wound therapy device and a kit for same with a housing material, a gasket disposed around at least a portion of the housing material, a non-woven absorption material, and a port. The gasket is sized and configured such that at least a first portion of the gasket will be adhered to a second portion of the gasket upon a folding of the housing material. A method of using a wound therapy device. | 2019-05-09 |
20190134285 | VENTRICULAR ASSIST ASSEMBLY, SYSTEM, AND METHOD - An implantable anastomotic assembly, which is configured to be attached to cardiovascular tissue, includes a connection interface, a plurality of outer plates, and a plurality of connectors configured to extend between and interconnect the connection interface and the plurality of outer plates, respectively, according to various embodiments. An outer plate of the plurality of outer plates is configured to be engaged against the cardiovascular tissue before a respective connector of the plurality of connectors is interconnected between the connection interface and the outer plate of the plurality of outer plates, according to various embodiments. | 2019-05-09 |
20190134286 | UPDATING A VAD SYSTEM WITHOUT STOPPING THE PUMP - A remote controller updating system for an implantable blood pump including an implantable blood pump, an implantable controller coupled to the implantable blood pump, and a pump driveline including a data network connection in communication with the implantable controller. The system may also include a pump connector coupled to the pump driveline, a remote controller couplable to the implantable blood pump, and a system update assembly including a system update connector couplable to the pump connector and a power source coupled to the system update connector. | 2019-05-09 |
20190134287 | VAD WITH INTRA-HOUSING FLUID ACCESS PORTS - A blood pump including a housing having an inflow tube defining a major axis spanning through the inflow tube and a flow path spanning along the major axis, a rotor disposed within the inflow tube, the rotor and the inflow tube defining a gap therebetween, a stator surrounding the inflow tube and the rotor, and the housing defining an access conduit spanning through the inflow tube and the stator transverse to the major axis, the access conduit being in communication with the gap. | 2019-05-09 |
20190134288 | METHOD AND DEVICE TO MONITOR PATIENTS WITH KIDNEY DISEASE - A medical monitoring device for monitoring electrical signals from the body of a subject is described. The medical monitoring device monitors electrical signals originating from a cardiac cycle of the subject and associates each cardiac cycle with a time index. The medical monitoring device applies a forward computational procedure to generate a risk score indicative of hyperkalemia, hypokalemia or arrhythmia of the subject. The medical monitoring device can adjust the forward computational procedure based upon clinical data obtained from the subject. | 2019-05-09 |
20190134289 | SODIUM AND BICARBONATE CONTROL SYSTEM - The invention relates to systems and methods for performing dialysis with closed-loop control of sodium and bicarbonate concentrations in the dialysate. The system and methods can use one or more conductivity sensors in a dialysate flow path to determine a water addition rate and a bicarbonate addition rate resulting in a dialysate having desired sodium and bicarbonate concentrations. | 2019-05-09 |
20190134290 | APPARATUS AND METHOD FOR DETERMINING A PARAMETER INDICATIVE OF THE PROGRESS OF AN EXTRACORPOREAL BLOOD TREATMENT - An apparatus and process for extracorporeal treatment of blood ( | 2019-05-09 |
20190134291 | PATIENT BUN ESTIMATOR FOR SORBENT HEMODIALYSIS - The invention relates to systems and methods for estimating a patient urea level at any arbitrary time during dialysis treatment. The systems and methods use either one or more urea sensors or any two of a pH sensor, ammonia sensor, and ammonium sensor to determine an amount of urea removed by a dialysate regeneration system. The systems and methods use the amount of urea removed by the dialysate regeneration system to estimate the patient urea level. | 2019-05-09 |
20190134292 | DEVICE FOR EXTRACORPOREAL BLOOD TREATMENT WITH GRAVIMETRIC BALANCING AND POSSIBILITY OF ULTRAFILTRATION - A device for extracorporeal blood treatment, in particular a dialysis machine, including an internal fluidic system to which a blood treatment unit, in particular a dialyzer, can be connected, the internal fluidic system comprising at least one balancing chamber on the fresh flow side for balancing fresh treatment fluid flowing to the blood treatment unit and at least one balancing chamber on the used flow side for balancing used treatment fluid flowing off the blood treatment unit, wherein the device has a measuring device for gravimetric detection of treatment fluid in the balancing chamber on the fresh flow side and/or a measuring device for gravimetric detection of treatment fluid in the balancing chamber on the used flow side. A method of balancing treatment fluid in such a device. | 2019-05-09 |
20190134293 | ACCELERATED METHOD FOR PREPARING PLATELET RICH PLASMA - Provided is an accelerated method for preparing platelet rich plasma (PrP) without centrifugation or filtration. The method comprises contacting a sample of whole blood with an anti-coagulant and an inducer of Rouleaux formation; allowing the mixture to stand thereby depleting the sample of RBCs, and collecting the platelet-rich plasma fraction. The PrP volume obtained by the present method is about 10-60% of the volume of the starting whole blood sample, and contains less than 200,000 RBCs and at least 100,000 platelets per microliter. | 2019-05-09 |
20190134294 | EXTRACORPOREAL BLOOD HEATING AND COOLING SYSTEM AND METHOD OF OPERATING AND MAINTAINING SAME - An extracorporeal blood heating and cooling system that is connectable to an oxygenator of a cardiopulmonary bypass system, the heating and cooling system comprising: a heater-cooler unit; a coolant flow circuit that is configured to pass coolant through the heater-cooler unit and the oxygenator; and a cardioplegia coolant circuit that is configured to pass coolant through the heater-cooler unit and a cardioplegia heat exchanger; wherein when the heating and cooling system is in a purging mode, the coolant flow circuit and the cardioplegia coolant circuit contain temperature-controlled coolant having a trisodium phosphate concentration of about 1-35 millimole/liter; wherein when the heating and cooling system is in a coolant mode, the coolant flow circuit and the cardioplegia coolant circuit contain temperature-controlled coolant having a trisodium phosphate concentration of about 1-10 millimole/liter; and wherein when the heating and cooling system is in the coolant mode or the purging mode, a first and second plurality of coolant conduits within the oxygenator and the cardioplegia heat exchanger are capable of maintaining a trisodium phosphate concentration ratio across the wall of such coolant conduits of at least 100:1, from the interior to the exterior of each coolant conduit. Methods of purging and operating such extracorporeal blood heating and cooling systems are also disclosed. | 2019-05-09 |
20190134295 | LOCAL DISINFECTION FOR PREFILLED DRUG DELIVERY SYSTEM - A therapeutic substance delivery device is provided for delivering therapeutic substance to the subject. A sterile fluid path includes a needle at an upstream end of the sterile fluid path and an injection assembly at a downstream end of the sterile fluid path. The delivery device engages with a prefilled therapeutic substance reservoir, such that a disinfection chamber is defined between the sterile fluid path and the reservoir. The needle penetrates the disinfection chamber and subsequently the reservoir when the therapeutic substance delivery device and the reservoir are engaged with one another. A disinfection assembly is disposed within the delivery device and configured to disinfect the disinfection chamber prior to the needle penetrating the disinfection chamber. Control circuitry activates the disinfection assembly, terminates the activation of the disinfection assembly, and subsequently drives the needle to penetrate the disinfection chamber and subsequently the reservoir. | 2019-05-09 |
20190134296 | SYSTEMS AND APPROACHES FOR STERILIZING A DRUG DELIVERY DEVICE - A shielding member for use in sterilizing drug container assemblies includes a housing. The housing includes a first shielding portion and a second shielding portion. The first shielding portion includes a first and second surfaces and a plurality of first bore portions extending between. The second shielding portion having a first and second surfaces and a plurality of second bore portions corresponding to and aligned with the plurality of first bore portions. The first and second bore portions cooperate to form a plurality of receptacles including a plurality of openings in the first surface of the first shielding portion of the housing. The receptacles are sized and configured to receive drug container assemblies, each comprising a container with a container contact region and a seal member disposed adjacent the container contact region to seal the contents of the container at a sealing interface, such that each drug container assembly is exposed out of the housing through one of the openings. | 2019-05-09 |
20190134297 | Patch-Sized Fluid Delivery Systems and Methods - A patch-sized fluid delivery device may include a reusable portion and a disposable portion. The disposable portion may include components that come into contact with the fluid, while the reusable portion may include only components that do not come into contact with the fluid. Redundant systems, such as redundant controllers, power sources, motor actuators, and alarms, may be provided. Alternatively or additionally, certain components can be multi-functional, such a microphones and loudspeakers that may be used for both acoustic volume sensing and for other functions and a coil that may be used as both an inductive coupler for a battery recharger and an antenna for a wireless transceiver. Various types of network interfaces may be provided in order to allow for remote control and monitoring of the device. | 2019-05-09 |
20190134298 | SYSTEM, METHOD, AND APPARATUS FOR ESTIMATING LIQUID DELIVERY - A pump includes a reservoir, a port, and a plunger. The reservoir delivers a liquid by discharging the liquid through the port coupled to the reservoir. A piston of the plunger defines a liquid side of the reservoir and a non-liquid side of the reservoir whereby movement of the plunger towards the liquid side of the reservoir discharges liquid through the port. The pump also includes a reference-volume assembly and/or a linear position sensor. The reference-volume assembly is coupled to the reservoir at an opposite end of the reservoir relative to the port and includes a reference-volume chamber in acoustic communication with the non-liquid side of the reservoir, a speaker disposed within the reference-volume chamber, and a reference microphone disposed within the reference-volume chamber. The pump estimate the amount of liquid discharged from the reservoir. | 2019-05-09 |
20190134299 | DEVICES AND METHODS FOR DELIVERING A BENEFICIAL AGENT TO A USER - A device for delivering a beneficial agent is provided and generally includes a cassette, a pump, and a delivery tube. The pump includes a pump housing containing a pump assembly having a fluid drive component. The pump housing has a receiving region disposed proximate the fluid drive component and further includes a rear closure portion. The rear closure portion includes a membrane disposed between the receiving region and the fluid drive component. The cassette includes a cassette housing, which has a cassette body region defining a fluid reservoir chamber therein. The cassette further includes a cassette base region having a boundary configured to be received by the receiving region. | 2019-05-09 |
20190134300 | SELF-INJECTION DEVICE | 2019-05-09 |
20190134301 | APPARATUS TO INJECT FLUIDS INTO BONE MARROW AND OTHER TARGET SITES - The present disclosure relates to an apparatus for providing access to bone marrow and delivering a quantity of fluid to an intraosseous space. The apparatus may include a driver having a housing and a drive shaft, and a plunger operating and cartridge drive mechanism for releasably retaining a portion of a cartridge assembly having a plunger assembly. A plunger operating assembly may be disposed within a longitudinal bore of the plunger operating and cartridge drive mechanism. The plunger operating assembly may include a plunger barrel having a chamber configured to receive a portion of the plunger assembly of the cartridge assembly. The apparatus may also include a drive housing for transmitting rotational forces from the drive shaft to the cartridge assembly. | 2019-05-09 |
20190134302 | IMPLANTABLE FLUID DELIVERY DEVICE - An implantable delivery device for delivering a fluid in a controlled manner, including a body having a chamber, a tube having an inlet and an outlet, at least a portion of the tube passing through the chamber, a drive pinion operatively connected to a motor for rotation, a wheel engaging with the drive pinion, and a ring operatively attached to the wheel, wherein the ring presses against the tube in a pressing zone and is driven by a rotation of the wheel relative to the body such that the pressing zone moves along the tube resulting from the rotation of the wheel to generate a movement of fluid present in the tube from the inlet to the outlet. | 2019-05-09 |
20190134303 | Needleless IV Injection Port - An injection port assembly comprises a body having a first mating structure and a second mating structure coupled together. A resilient barrier is received within the body and compressible between a less compressed first position in which fluid flow through the injection port assembly is blocked, to a more compressed second position in which fluid flow through the injection port assembly is permitted. A hollow cannula is coupled to the first mating structure and configured to be received within the resilient barrier. The hollow cannula has a distal end portion configured to extend through the resilient barrier when the resilient barrier is in the more compressed second position. The hollow cannula is opaque and both the second mating structure and the resilient barrier are transparent, so that any fluid leakage into the internal cavity of the resilient barrier is visible through the resilient barrier and the second mating structure against an opaque background provided by the opaque cannula. | 2019-05-09 |
20190134304 | PRESSURE SPIKE ABSORBING SYSTEMS - An apparatus for coupling to a fluid delivery system and for receiving a fluid into the apparatus; a portion of the apparatus permitting a change in shape or size to accommodate the fluid volume or pressure received therein. The apparatus including a housing with a cavity, an expandable reservoir with an opening and a passage, and a cap; the expandable reservoir positioned within the cavity and coupled to a fluid source. The expandable reservoir includes an unrestrained orientation when a fluid volume or pressure therein is below a threshold, and an expanded orientation, when the fluid volume or pressure therein is above the threshold; the expandable reservoir moving toward the expanded orientation to accommodate a fluid volume or pressure received through an opening, and the expandable reservoir moving toward the unrestrained orientation to direct a fluid volume or pressure through an opening. | 2019-05-09 |
20190134305 | SMART MEDICATION DELIVERY DEVICES FOR PROVIDING USERS WITH DELIVERY INFOMATICS AND METHODS OF USING SAME - A medication delivery device (MDD) (e.g., injection pen, wearable pump) is paired with an external device (e.g., smart phone, iPad, computer) via wireless link or wireline connection. The MDD provides to the external device captured data from the flow sensor relating to medicine delivery to a patient to ensure complete delivery and minimize MDD misuse or malfunction or inaccuracies in dosing. The MDD can have Bluetooth™ and/or near field communication (NFC) communication circuits for proximity-based pairing and connectivity with the external device for real-time or deferred transfer of captured data to the external device, depending on memory and power availability at the MDD. The MDD or external device can use captured data and corresponding time stamps to determine flow infomatics such as flow rate, total dose delivered, and dose completion status. An LED on the MDD indicates states such as powered on, paired, delivery in progress and delivery completion. | 2019-05-09 |
20190134306 | SYSTEM FOR MANAGING ANTI-COAGULANT INFUSIONS IN PATIENTS - An anti-coagulant maintenance system for use in the treatment of patients with deep-vein thrombosis (DVT), pulmonary embolism (PE), Acute Coronary Syndrome, need for prophylactic anticoagulation or another related condition. The system establishes and adjusts the dosing of an anti-coagulant based upon periodic blood testing of a system specified frequency. Warning or alert messages or signals are produced if blood tests are not performed and a dosage adjustment is made based upon a coagulation test result outside of an established normal range. It is particularly useful for patients in a hospital or in-patient environment. | 2019-05-09 |
20190134307 | SYSTEMS AND METHODS FOR PATIENT CARDIOVASCULAR AND RESPIRATORY MANAGEMENT - An information display and control system that enables a fast and easy understanding and management of the status of the patient's dialysis is disclosed. Also disclosed is an information display and control system that enables a fast and easy understanding and management of the status of the patient's cardiovascular and ventilation systems. The system can control management of a patient's dialysis, as well as administration and management of a patient's medication and fluids. The display is organized by goals related to management of patient's dialysis machine, blood flow, dialyzer flow, and patient's body weight. The display is also organized by goals related to management of patient's cardiovascular system, ventilation system, and medications and fluids administration and management. Such goals include urea reduction rate, urea reduction ratio, fractional urea clearance, total urea reduction, dialysis treatment duration, hemodynamics, oxygenation, CO | 2019-05-09 |
20190134308 | SYSTEM AND METHOD FOR MONITORING BLOOD CELL LEVELS IN BLOOD FLOW USING PPG TECHNOLOGY - A biosensor includes a photoplethysmography (PPG) circuit configured to obtain spectral responses at one or more wavelengths from skin tissue of the patient over a predetermined time period. The biosensor monitors the color of the blood to detect a change in the baseline color of blood flow over the predetermined time period. The biosensor may determine a level of red blood cells or white blood cells or a risk of an infection using the change in the baseline color of blood flow. The biosensor may also detect other parameters to detect an infection or identify a type of infection including liver enzyme levels, nitric oxide levels, heart rate or vasodilation in the underlying tissue. | 2019-05-09 |
20190134309 | AN AUTO-INJECTOR DEVICE - An auto-injector device comprises a stopper for expelling a medicament out of a medicament reservoir; a driving element which has a first configuration and a second configuration and is configured to change shape from the first configuration to the second configuration when the temperature of the driving element is raised above a shape change temperature, so as to drive the stopper of the syringe mechanism through the medicament reservoir; and a heating mechanism configured to actively heat the driving element. The heating mechanism is a chemical heating element configured to generate heat through an exothermic process or comprises a fluid reservoir for retaining a fluid; a heater configured to heat the fluid in the fluid reservoir; a pump configured to expel the fluid out of the fluid reservoir; and a connecting conduit arranged to carry the fluid from the fluid reservoir to the driving element. | 2019-05-09 |
20190134310 | Drug Delivery Device for Drug Suspensions - In one aspect of the subject invention, a drug delivery device is provided which includes a reservoir for containing a medicament and has a proximal end and a distal end, the medicament including a suspension of solids in a liquid carrier. Further, the drug delivery device includes a needle in fluid communication with the reservoir and having a distal end for injection into a patient, and a proximal end in the reservoir. An accumulation surface is defined at least partially about the needle, distally of the proximal end of the needle. The accumulation surface defines a distally-extending indentation which is sized and shaped to collect, during use, solids that come out of suspension. Advantageously, with the subject invention, the accumulation surface allows for solids to accumulate at a location spaced from the proximal end of the needle, thereby minimizing the possibility of clogging the needle. | 2019-05-09 |
20190134311 | Drug Delivery Device - A drug delivery device for administering a drug is presented having a body adapted to retain a cartridge containing a drug, at least one electrical unit and a port for electrically contacting the electrical unit, an adapter for attaching an injection needle to the drug delivery device, a safety mechanism arranged to prevent contacting the electrical unit through the port whilst an injection needle is in fluid communication with the cartridge and arranged to prevent establishing a fluid communication between an injection needle and the cartridge whilst the port is configured to allow contacting the electrical unit. | 2019-05-09 |
20190134312 | SYRINGE WITH ROTATABLE ELEMENT, SYSTEMS INCLUDING THE SYRINGE, AND ASSOCIATED METHODS - A syringe includes a barrel and a rotatable element on the barrel; for example at a proximal location along the length of the barrel. The rotatable element rotates at least partially around the barrel. When a handle is associated with the rotatable element, the barrel may rotate as the handle his held substantially stationary or the handle may be rotated while the barrel and any peripheral device secured thereto remain substantially stationary. When handles are associated with a rotatable element that may be removed from a barrel, a barrel that is disassembled from the rotatable element may be replaced with another barrel of the same or a different configuration. Methods of using a syringe with a rotatable element on a barrel thereof are also disclosed. | 2019-05-09 |
20190134313 | DRUG DELIVERY DEVICE - A drug delivery device comprises a medicament reservoir attached to a housing, a drive mechanism comprising a plunger movable relative to the housing, a dose selecting element releasably coupled to the drive mechanism and rotatable relative to the housing, a trigger axially movable relative to the housing, and a limiter selectively permitting and preventing axial movement of the trigger depending on the amount of a selected dose. The limiter is constrained to the dose selecting element and to the trigger. One of the limiter or a component part is axially coupled to the housing comprises a track which is in engagement with a blocking feature of the other of the limiter or the component part axially coupled to the housing. The track comprises a narrow section limiting relative movement between the track and the blocking feature and a wide section permitting relative movement between the track and the blocking feature. | 2019-05-09 |
20190134314 | MEDICAMENT DELIVERY DEVICE WITH TWO DRIVE SPRINGS - A medicament delivery device includes a case, a first plunger, a second plunger arranged telescopically with the first plunger, a first drive spring biasing the second plunger relative to the case, and a second drive spring biasing the first plunger relative to the second plunger. | 2019-05-09 |
20190134315 | INJECTION DEVICE WITH DOSING CONTROL MEANS - An injection device provides a casing which accommodates or forms a reservoir for a liquid drug; a plunger rod which can move relative to the casing in an axially forward direction to deliver the drug; a dosing means which can move in the forward direction relative to the casing to prime the reservoir and which can rotate relative to the casing for selecting a dose to be injected, wherein rotation of the dosing means relative to the casing is prevented until a priming operation for priming the reservoir is completed; d)wherein the dosing means comprises a dosing control means which is configured to enable rotation of the dosing means at the end of the priming stroke for selecting the dose and to prevent a rotation of the dosing means back into the position which the dosing means had at the end of the priming stroke relative to the casing. | 2019-05-09 |
20190134316 | NEEDLE UNIT - The present invention provides a needle unit configured to be mounted to medical syringe, the needle unit including a needle member having a longitudinally extending inner space and having a needle hole formed in a side surface of a front end and an opening formed in a base end, the inner space being in communication with the outside through the needle hole and the opening, a base portion for supporting the base end of the needle member and communicating between the syringe and the inner space of the needle member by being attached to the syringe, a slide member movable along an outer peripheral surface of the needle member and capable of taking a first position to close the needle hole and a second position to uncover the needle hole in the base end portion side of the first position, a biasing member that biases the slide member from the second position side to the first position side; and a cap removably mounted to the base portion and is configured to cover the needle member. | 2019-05-09 |
20190134317 | ADHESIVE AND PERIPHERAL SYSTEMS AND METHODS FOR MEDICAL DEVICES - Fill stations and base stations are provided for personal pump systems. The fill stations may be opened and closed to accept a reservoir and to allow fluid to be introduced into the reservoir for use with personal pump systems. The fill stations may hold the reservoir at a tilt relative to an underlying surface and may discourage overfilling of the reservoir. The filling stations may also include viewing windows having fluid lines marked thereon for indicating volume of fluid within the reservoir. | 2019-05-09 |
20190134318 | INHALATION DEVICE WITH CONSUMPTION METERING WITHOUT AIRFLOW SENSORS - An inhalation device for inhaling a vaporized substance that includes metering capabilities to inform a user when a particular amount of substance has been consumed. The device includes an inlet having an opening, an outlet, a processor, an atomizer configured to vaporize an unvaporized substance into a vaporized substance. The device further includes a channel positioned between the atomizer and the outlet, wherein the vaporized substance flows downstream from the atomizer to the outlet via the channel, a light signal device, wherein the light signal device emits light, and a light sensor, wherein the light sensor senses the light from the light signal device. In addition, the light signal device and the sensor are positioned in the channel such that the vaporized substance can flow past the sensor and the light signal device, the opening is configured to allow entry of air into the device that flows to the atomizer, the inlet is configured such that the air flows at a substantially constant rate, and the processor, using the substantially constant rate and the data from the light sensor, is configured to meter an amount of vapor consumed by a user. | 2019-05-09 |
20190134320 | DUAL CHAMBER VAPORIZATION TANK - A dual chamber vaporization tank comprises an inner tube, an intermediate tube, an outer tube, and a mouthpiece assembly. An e-liquid chamber is defined by a first annulus between the inner tube and the intermediate tube. The tank further comprises a porous ceramic ring having a heating coil disposed on an inner surface and an outer surface in fluid communication with the e-liquid chamber. An airflow path is defined from the surrounding air through an airflow aperture into a second annulus between the intermediate tube and the outer tube, along the second annulus in a first direction, through the heating coil in a second direction opposite the first direction, and through the inner tube. | 2019-05-09 |
20190134321 | DRUG DELIVERY DEVICE WITH ELECTRONICS - A device for delivering medication to a user may include a main body, an electronics module, and a slider. The main body may include a mouthpiece, a medication reservoir, and a mouthpiece cover, where the mouthpiece cover may be hinged to the main body. The electronics module may include a communication circuit, a pressure sensor, and a switch. The slider may be configured to engage the switch when the mouthpiece cover moves from a closed position to an open position. The switch may be configured to switch the electronics module from an off state or a sleep state to an active state. The electronics module may be configured to never return to the off state after the mouthpiece cover is moved to expose the mouthpiece for the first time by the user. | 2019-05-09 |
20190134322 | DEVICE FOR INHALATION-SYNCHRONISED DISPENSING OF A FLUID PRODUCT - A device including a body with a mouthpiece, a fluid reservoir mounted to slide relative to the body, a valve, a blocking element movable and/or deformable between a blocking position in which the metering valve cannot be actuated, and an actuation position in which the metering valve can be actuated; a trigger element movable and/or deformable between a locking position and a release position; and an inhalation-controlled trigger system. The blocking element including a projection that, in the locking position, co-operates with a shoulder of the trigger element to define a latch that prevents the blocking element from moving and/or deforming. The blocking element includes a lateral projection that, in the locking position of the trigger element, co-operates with a bearing surface of the trigger element to form, in the locking position of the trigger element, a second contact point between the blocking element and said trigger element. | 2019-05-09 |
20190134323 | DISPOSABLE MONODOSE INHALER FOR POWDERED MEDICAMENTS - An inhaler for powdered medicaments is provided. It consists of a substantially smoking pipe-shaped hollow body that has a first portion, for housing a cartridge of powdered medicament, and a second portion for delivering the medicament by means of an airstream that carries the powder from an inner drop region along a delivery duct whose end is suitable to be placed in a patient's mouth, the intake of the air being achieved through at least three air intakes arranged symmetrically with respect to the longitudinal midplane of the inhaler, which includes a support base for the cartridge in which oriented flow channels are formed that extend between the three air intakes and the inner powder drop region. | 2019-05-09 |
20190134324 | METHODS AND DEVICES FOR CONTROLLED DRUG VAPORIZATION - The present invention an electronic inhaler for the delivery of pharmaceuticals through vaporization. | 2019-05-09 |