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19th week of 2009 patent applcation highlights part 50
Patent application numberTitlePublished
20090118502BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME - The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.2009-05-07
20090118503FAAH INHIBITORS - Indole derivatives that are useful for treating pain, inflammation and other conditions are described. Certain of the compounds are benzyl derivatives and others are benzoyl derivatives. The compounds are substituted at least at the 3 position of the indole.2009-05-07
20090118504Novel phosphonic acid compounds as inhibitors of serine proteases - The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.2009-05-07
20090118505PROCESS FOR THE PREPARATION OF SUBSTITUTED PHENYLALANINES - Intermediates and synthetic processes for the preparation of substituted phenylalanine-based compounds (e.g., of Formula I) are disclosed:2009-05-07
200901185066,11-BRIDGED BIARYL MACROLIDES - The present invention discloses compounds of formula I, II or, or pharmaceutically acceptable salts, esters, or prodrugs thereof:2009-05-07
20090118507Method for Preparing (3-Chloro-4-Fluorophenyl)-(4-Fluoro-4--Piperidin-1-Yl)-Methanone and Novel Intermediate Pyrimidine Derivatives - The present invention concerns the method for preparing (3-chloro-4-fluorophenyl)-(4-fluoro-4-{[(5-methyl-pyrimidin-2-ylmethyl)-amino]-methyl}-piperidin-1-yl)-methanone of formula (II) by condensation between 5-methyl-pyrimidin-2-methylamine of formula (I) and cyanohydrin of formula (III).2009-05-07
20090118508Novel phosphonic acid compounds as inhibitors of serine proteases - The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.2009-05-07
20090118509PREPARATION OF [2-METHYL-5-PHENYL-3-(PIPERAZIN-1-YLMETHYL)] PYRROLE DERIVATIVES - A process for the preparation of compounds of Formula I and their pharmaceutically acceptable acid addition salt2009-05-07
20090118510Dark coloured azo dyes - The present invention relates to 2009-05-07
20090118512Process for Preparing 6,7-Dihydro-5H-Imidazo[1,5-A]Pyridin-8-One - 6,7-Dihydro-5H-imidazo[1,5-a]pyridin-8-one (I), is obtainable in high yields by: 1) a process which proceeds from a suitably protected C-(3-hydroxypyridin-2-yl)methylamine whose amine is converted to the formamide which is then cyclized to the imidazo[1,5-a]pyridine and hydrogenated to the 6,7-dihydro-5H-imidazo[1,5-a]pyridin-8-one, and suitably protected C-(3-hydroxypyridin-2-yl)methylamines can be prepared either in 2 steps proceeding from commercially available 3-hydroxy-2-cyanopyridine [932-35-4] or in 3 steps proceeding from commercially available 2-hydroxymethylpyridin-3-ol [14173-30-9]; 2) a process for preparing 4-hydroxy-1-(1H-imidazol-4-yl)butan-1-one, an intermediate from the synthesis of 6,7-dihydro-5H-imidazo[1,5-a]pyridin-8-one (formula I), as described in WO 2002/040484, proceeding from N,N-dimethyl-2-(trialkylsilanyl)imidazole-1-sulphonamide by lithiation and subsequent reaction with a suitably protected 4-hydroxybutyraldehyde, followed by oxidation of the secondary alcohol, acid-induced deprotection of the imidazole and deprotection of the alcohol functionality; 3) a process which proceeds from 5,6,7,8-tetrahydroimidazo[1,5-a]pyridine [38666-30-7], which is oxidized.2009-05-07
20090118513Chemical Compounds - The present invention provides a compound of a formula (I):2009-05-07
20090118514PROCESSES FOR PREPARING PIOGLITAZONE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS - An improved process for the preparation of pioglitazone and its pharmaceutically acceptable salts by reducing 5-[4-[2-(5-ethyl-2-pyridyl)ethoxy]benzilidene]-2,4-thiazolidinedione with sodium borohydride in presence of a cobalt ion and dimethyl glyoxime. More particularly the cobalt ion used is cobalt chloride hexahydrate, or, cobalt (II) nitrate hexahydrate in presence of mixture of DMF and water as solvents.2009-05-07
20090118515PROCESS FOR PREPARING INTERMEDIATES USEFUL TO PREPARE CERTAIN ANTIBACTERIAL N-FORMYL HYDROXYLAMINES - The present invention is directed to a process for preparing intermediates that are useful to prepare certain antibacterial N-formyl hydroxylamine compounds which are peptide deformylase inhibitors.2009-05-07
20090118516Process for preparing ligands of ppardelta and the intermediate compounds for preparing the same - The present invention provides a process for preparing thiazole derivatives of formula (I), that activate the delta subtype of the human Peroxisome Proliferator Activated Receptor (hPPAR δ), and also provides compounds of formula (II), (IV), (X), (XI) and (XII), intermediate compounds for preparation of the above compounds of formula (I).2009-05-07
20090118517Purification process for anastrozole intermediate - The invention is directed to processes for purifying the Anastrozole intermediate, 3,5-bis(2-cyanoisopropyl)toluene, processes for producing Anastrozole, processes for preparing Anastrozole pharmaceutical compositions, and Anastrozole and Anastrozole pharmaceutical compositions prepared with the processes of the invention.2009-05-07
20090118518Fluvastatin sodium crystal forms, processes for preparing them, compositions containing them and methods of using them - Provided are crystalline forms of fluvastatin sodium and processes for their preparation.2009-05-07
20090118519Production Method of Polycyclic Lactams - A process for producing lactams of formula (1) below, including the step of reacting lactones of formula (2) below with imides of any of formulae (3a), (3b) and (3c) to thereby obtain corresponding carboxylic acids (step A); the step of esterifying the carboxylic acids into corresponding esters (step B); and the step of reacting the esters with amines to thereby obtain lactams of the formula (1) (step C). In the formulae (1)-(2) and (3a)-(3c), when R2009-05-07
20090118520PROCESS FOR PREPARATION OF (3R, 5R)-7-[2-(4-FLUOROPHENYL)-5-ISOPROPYL-3-PHENYL-4-[(4-HYDROXY METHYL PHENYL AMINO) CARBONYL]-PYRROL-1-YL]-3,5-DIHYDROXY-HEPTANOIC ACID HEMI CALCIUM SALT - The present invention relates to processes for the preparation of (3R, 5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxy methyl phenyl amino)carbonyl]-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid hemi calcium salt.2009-05-07
20090118521NANOENGINEERED ORGANIC NONLINEAR OPTICAL GLASSES - Nonlinear optically active compounds having film-forming properties, films including the compounds, methods for making the compounds and films, and electro-optic devices including the films and compounds.2009-05-07
20090118522Synthesis of Cyclopentadienedithiophene Derivatives - A process for preparing cyclopentadiene derivatives having formula (I) wherein T2009-05-07
20090118523Separation of Propylene Oxide from a Mixture Comprising Propylene Oxide and Methanol - A method of separating propylene oxide from a mixture (M) comprising propylene oxide and methanol, said method comprising: (i) introducing said mixture (M) into an extractive distillation column; (ii) additionally introducing an extracting solvent into said extractive distillation column; (iii) distilling propylene oxide overhead from said extractive distillation column as top stream; (iv) withdrawing a bottoms stream from said extractive distillation column; (v) compressing the top stream obtained overhead in (iii) by means of at least one compressor to give a compressed vapor.2009-05-07
20090118524Process for Removing Volatile Components from a Substance Mixture & Apparatus for Performing this Process - A process and an apparatus separate a volatile component from a substance mixture (raw product). The substance mixture is heated, the volatile component is at least partly evaporated and then the vapor formed is condensed. To improve the separating action, the condensate, in the region of the point of condensation, is contacted with a liquid in which the condensate dissolves.2009-05-07
20090118525Reduction of sterols and other compounds from oils - Disclosed are methods of removing and/or reducing compounds from oils (e.g., marine oils) and oils prepared by the disclosed methods. Methods of bleaching oils are also disclosed.2009-05-07
20090118526Preparation of MnB12H12 - A method for producing M2009-05-07
20090118527FULLERENE DERIVATIVE AND METHODS FOR PRODUCING SAME - The present invention provides a method for producing a fullerene derivative comprising reacting: a serene; an organometallic reagent (A) comprising B, Al, Zn, Sn, Pb, Te, Ti, Mn, Zr or Sm; and a copper compound (B).2009-05-07
20090118528NATURAL GAS DESULFURIZATION - A method for desulfurizing natural gas includes contacting the natural gas with an adsorbent which preferentially adsorbs at least one of hydrogen sulfide, COS, sulfur odorants, or combinations thereof, at a selected temperature and pressure, thereby producing desulfurized natural gas and an at least one of hydrogen sulfide/COS/sulfur odorant/combinations thereof-rich adsorbed component. The adsorbent includes a copper species adapted to form π-complexation bonds and direct metal-sulfur bonds with the at least one of hydrogen sulfide, COS, sulfur odorants, or combinations thereof, and wherein the preferential adsorption occurs by π-complexation and direct metal-sulfur bonding.2009-05-07
20090118529Highly reactive zinc form, method for the production thereof, and use of the same - The invention relates to a highly reactive zinc form, to a method for the production thereof, and to the use of said highly reactive zinc form in synthetic chemistry.2009-05-07
20090118530Industrial Process for Production of Aromatic Carbonate - It is an object of the present invention to provide a specific process that enables an aromatic carbonate required for producing a high-quality high-performance aromatic polycarbonate to be produced industrially in a large amount (e.g. not less than 1 ton/hr) stably for a prolonged period of time (e.g. not less than 1000 hours, preferably not less than 3000 hours, more preferably not less than 5000 hours) from a cyclic carbonate and an aromatic monohydroxy compound. When producing an aromatic carbonate from a cyclic carbonate and an aromatic monohydroxy compound, the above object can be attained by carrying out a step of: (I) producing a dialkyl carbonate and a diol using a reactive distillation column having a specified structure, and (II) producing the an aromatic carbonate using a first reactive distillation column having a specified structure.2009-05-07
20090118531NOVEL SUPPORTED CATALYST FOR AMMOXIDATION - Supported catalysts comprising a support having a mean diameter of ≦78 μm, a vanadium oxide, an antimony oxide, one or more alkali metal or alkaline earth metal oxides, and one or more oxides of tungsten, molybdenum, titanium, iron, cobalt, nickel, manganese, potassium, copper or mixtures thereof; processes for preparing said catalysts; and processes for preparing an aromatic or heteroaromatic nitrile in the presence of such a supported catalyst.2009-05-07
20090118532Process for the Synthesis of Mandipropamid and Derivatives Thereof - A process for the preparation of a compound of formula (I) wherein: R is an alkynyl group; R2009-05-07
20090118533METHOD FOR THE CONTINUOUS PRODUCTION OF UNSATURATED CARBOXYLIC ACID ANHYDRIDES - The invention relates to a method for the continuous production of unsaturated carboxylic acid anhydrides of general formula (I): R—C(O)—O—C(O)—R (I), wherein R is an unsaturated organic group with 2 to 12 C atoms, by reaction of a ketene with an unsaturated carboxylic acid of general formula (II): R—COOH (II), wherein R is defined as above, in an apparatus which has a reaction zone (2009-05-07
20090118534METHOD OF PRODUCING OPTICALLY ACTIVE (S)-7-HYDROXY-6-METHYLHEPTAN-2-ONE AND PRECURSOR THEREOF - Provided is a method capable of industrially producing optically active (S)-7-hydroxy-6-methylheptan-2-one and its precursor simply and efficiently. The production method, allows a R-body preferentially hydrolyzable Aspergillus microorganism-derived esterase to act on a 2-methyl-6-oxoheptanoate (II), to produce an optically active (S)-2-methyl-6-oxoheptanoate (III).2009-05-07
20090118535PROCESS FOR PRODUCING OPTICALLY ACTIVE ESTER - A process for producing an optically active 2-hydroxybutyric ester (1), characterized by including reacting an optically active 2,3-epoxybutyric ester (2) with a thiol in the presence of scandium trifluoromethanesulfonate or ytterbium trifluoromethanesulfonate, to thereby produce Compound (3), and subjecting Compound (3) to desulfurization reaction:2009-05-07
20090118536Process for the Production of Aromatic Carboxylic Acids in Water - A process is disclosed for producing at least one aromatic carboxylic acid by contacting a liquid reaction mixture comprising an aromatic feedstock and water with oxygen in the presence of a bromine-free metal catalyst composition wherein the metal catalyst composition has activity in the absence of bromine for oxidation of the aromatic feedstock with at least 80% conversion to oxidized aromatic derivatives of the aromatic feedstock and with at least 80% selectivity to the aromatic carboxylic acid. This process operates in water without the use of bromine at temperatures and residence times substantially the same as conventional processes for aromatic carboxylic acid manufacture, as well as with less total burning and with yields to product equivalent or higher than conventional processes.2009-05-07
20090118537Process for the Preparation of Contrast Agents - The present invention refers to a process for preparing a compound of formula (I) through a carboxymethylation reaction occurring in the presence of a suitable alkylating agent and of a base, without the need of monitoring the pH of the reaction environment. The compound of formula (I) is a useful intermediate in the preparation of diagnostic contrast agents for MRI techniques.2009-05-07
20090118538PROCESS FOR PREPARATION OF PURE ACITRETIN - Processes and systems for the preparation of substantially pure acitretin based on reacting crude acitretin and an amine in presence of a suitable solvent to provide a salt that is then reacted with an organic acid to obtain substantially pure acitretin.2009-05-07
20090118539GENERATION OF ENDO- AND/OR EXO-NORBORNENECARBOXALDEHYDE AS AN INTERMEDIATE TO FUNCTIONALIZED NORBORNENES - Embodiments in accordance with the present invention provide for forming essentially pure diastereomers of 5/6-substituted norbornene-type monomers. Further, embodiments in accordance with the present invention encompass polymerizing such diastereomers to form addition or ROMP polymers where a desired exo-/endo-ratio of the diastereomers is provided to the polymerization, such ratio designed to provide a desired ratio of endo-/exo-structured repeating units for a resulting polymer to have desired physical or chemical properties.2009-05-07
20090118540Method For Producing Pyruvic Acid - The invention relates to a method for the production of pyruvic acid.2009-05-07
20090118541Method for producing glycolic acid - Provided is a production method of glycolic acid having a first step of preparing glycolonitrile from formaldehyde and hydrocyanic acid and a second step of hydrolyzing the glycolonitrile into glycolic acid directly or via a glycolate salt, which method can produce glycolic acid in easy production and purification steps while consuming less energy. In the production method, by carrying out the first and second steps continuously or by storing the glycolonitrile obtained in the first step at pH 4 or less and carrying out a hydrolysis reaction of the second step at from pH 5 to 9, a production yield of glycolic acid, activity for the production of glycolic acid and accumulated concentration of glycolic acid are improved, resulting in the production of glycolic acid having an improved purity and quality.2009-05-07
20090118542Process for Production of Optically Active Carboxlic Acid Compound - An optically active acylated camphorsultam can be hydrolyzed with an aqueous solution of an alkaline earth metal hydroxide in the presence of a branched alkanol, to give a corresponding optically active carboxylic acid compound in safely and inexpensively.2009-05-07
20090118543METHOD FOR PRODUCING TRIFLUOROMETHANESULFONIC ANHYDRIDE - This method for producing trifluoromethanesulfonic anhydride reacting trifluoromethanesulfonic acid with phosphorus pentoxide to produce trifluoromethanesulfonic anhydride, wherein hardening of the reaction solution due to polyphosphoric acid, which is produced as a byproduct, is prevented by using an excess amount of trifluoromethanesulfonic acid with respect to the phosphorus pentoxide.2009-05-07
20090118544Process for the synthesis of (7-methoxy-1-naphthyl) acetonitrile and its application in the synthesis of agomelatine - A process for the industrial synthesis of the compound of formula (I)2009-05-07
20090118545MICROREACTOR TECHNOLOGY TO BUCHWALD-HARTWIG AMINATION - A process for forming an arylamine compound, including reacting an arylamine and an aryl halide in the presence of a palladium ligated catalyst, a base and a suitable solvent in a microreactor.2009-05-07
20090118546METHODS FOR STABILIZING LITHIATED HALOGEN-SUBSTITUTED AROMATIC COMPOUNDS - The present invention provides novel methods for stabilizing lithiated halogen-substituted aromatic compounds. In particular, the method is useful for the preparation of 2-methoxy-5, 6-difluorobenzaldehyde, an important intermediate for the preparation of [4-amino-2-(1-methanesulfonylpiperidin-4-ylamino) pyrimidin-5-yl](2,3-difluoro-6methoxyphenyl)methanone, a potent and selective inhibitor of CDK4/Cyclin D1, CDK2/Cyclin E and CDK1/Cyclin B. The method is also useful for stabilizing other lithiated halogen-substituted aromatic compounds and is particularly useful for scale up reactions where the exothermic nature of the reaction can lead to reaction runway.2009-05-07
200901185474-(4-ALKYLCYCLOHEXYL)BENZALDEHYDE - A process for effectively producing a 4-(4-alkylcyclohexyl)benzaldehyde, 4-(cyclohexyl)benzaldehyde, a 4-(trans-4-alkylcyclohexyl)benzaldehyde and a (trans-4-alkylcyclohexyl)benzene useful for electronic material applications such as liquid crystals and for pharmaceutical and agrochemical applications, etc., are disclosed. The present invention provides (1) a process for producing a 4-(4-alkylcyclohexyl)benzaldehyde or 4-(cyclohexyl)benzaldehyde by formylating a (4-alkylcyclohexyl)benzene or cyclohexylbenzene with carbon monoxide, (2) a process for producing a 4-(trans-4-alkylcyclohexyl)benzaldehyde by formylating a (4-alkylcyclohexyl)benzene having a cis/trans molar ratio of 0.3 or less with carbon monoxide, and (3) a process for producing a (trans-4-alkylcyclohexyl)benzene by isomerizing a mixture of the cis and trans isomers of a (4-alkylcyclohexyl)benzene, all of the processes being performed in the presence of HF and BF2009-05-07
20090118548HYDROFORMYLATION PROCESS AND PRODUCT SEPARATION WITH IMPROVED RECOVERY OF RHODIUM - A non-aqueous hydroformylation process with liquid catalyst recycle involving a hydroformylation step and one or more stages of phase separation to recover a high molecular weight aldehyde product with efficient recovery of rhodium catalyst. The process includes a hydroformylation step to prepare a non-aqueous hydroformylation reaction product composition comprising one or more aldehyde products, one or more conjugated polyolefins, a rhodium-organophosphorus ligand complex, free organophosphorus ligand, and an organic solubilizing agent for said complex and said free ligand, and thereafter one or more stages of phase separation using added water under a carbon monoxide gas, hydrogen gas, or a mixture thereof. The process requires a specific range of total pressure for the hydroformylation, a specific range of total pressure for at least one of the separation stages, and a minimum sum of the total pressure of the hydroformylation step and the total pressure of the separation stage containing said gas.2009-05-07
20090118549Process for Production of Acrolein - There is provided a process for producing acrolein from glycerin, exhibiting a suppressed decrease in the yield of acrolein with time. In the process for producing acrolein by dehydrating glycerin in the presence of a catalyst containing a metal phosphate, one, or two or more, metal phosphates are used, which are selected from aluminum salts, zirconium salts, manganese salts, alkali metal salts (provided that the alkali metal is sodium, potassium, or cesium, and the ratio between the mole number (M) of the alkali metal and the mole number (P) of phosphoric acid (i.e., M/P ratio) in the metal phosphate is 2.0 or lower), alkali earth metal salts (provided that the ratio between the mole number (M) of the alkali earth metal and the mole number (P) of phosphoric acid (i.e., M/P ratio) in the metal phosphate is 1.0 or lower), and the like.2009-05-07
20090118550PROCESS FOR PREPARING HIGH PURITY MONOCARBOXYLIC PERFLUOROPOLYETHERS - A process for preparing monocarboxylic perfluoropolyethers of formula: A-O-(R2009-05-07
20090118551Integrated Separation and Preparation Process - Integrated separation and preparation process comprising a gas separation process wherein a first component is separated from a mixture of components by diffusion of the first component through a porous partition into a stream of sweeping component; and a preparation process wherein the sweeping component is used as feed. Separation unit and device for use in such a process and industrial set-up for use in such a process.2009-05-07
20090118552PROCESS FOR PRODUCING 2-PERFLUOROALKYLETHYL ALCOHOL - In a first sulfation step, 2-perfluoroalkylethyl iodide is brought into contact with fuming sulfuric acid to obtain a reaction mixture comprising 2-perfluoroalkylethyl sulfate and bis(2-perfluoroalkylethyl)sulfate. Then, in a first hydrolysis step, 2-perfluoroalkylethyl sulfate produced in the first sulfation step is hydrolyzed to obtain a reaction mixture comprising 2-perfluoroalkylethyl alcohol. In a second sulfation step, bis(2-perfluoroalkylethyl)sulfate produced in the first sulfation step is brought into contact with fuming sulfuric acid to obtain a reaction mixture comprising 2-perfluoroalkylethyl sulfate. Then, in a second hydrolysis step, 2-perfluoroalkylethyl sulfate produced in the second sulfation step is hydrolyzed to obtain a reaction mixture comprising 2-perfluoroalkylethyl alcohol. According to such procedures, 2-perfluoroalkylethyl alcohol can be obtained in a high yield.2009-05-07
20090118553METHOD FOR DIRECT-OXYGENATION OF ALKANE GASES - A method for alkyl oxygenate (e.g., methanol) manufacture via partial oxidation of alkane (methane) uses an injectively-mixed backmixing reaction chamber in fluid communication with a tubular-flow reactor. Alkyl free radicals are induced in the backmixing reaction chamber prior to being fed through a flow-restriction baffle to the tubular-flow reactor. Injective intermixing of feed streams agitates the backmixing reaction chamber. In one embodiment, a variable position flow restriction baffle is axially moved to commensurately modify the backmixing reaction chamber and tubular-flow reactor volumes. In another embodiment, the tubular-flow reactor is quenched with a variable position quenching input. The method further provides for condensing the output stream from the reaction system in a condensing scrubber and also for recycling a portion of the scrubbed output stream to the reactor system.2009-05-07
20090118554Process for the preparation of 1,3,3,3-tetrafluoropropene and/or 2,3,3,3-tetrafluoropropene - A process for the manufacture of CF2009-05-07
20090118555INTEGRATED HFC TRANS-1234ZE MANUFACTURE PROCESS - An integrated process for the manufacture of HFO trans-1,3,3,3-tetrafluoropropene (HFO trans-1234ze) by first catalytically dehydrofluorinating 1,1,1,3,3-pentafluoropropane to thereby produce a mixture of cis-1,3,3,3-tetrafluoropropene, trans-1,3,3,3-tetrafluoropropene and hydrogen fluoride. Then optionally recovering hydrogen fluoride, catalytically isomerizing cis-1234ze into trans-1234ze, and recovering trans-1,3,3,3-tetrafluoropropene.2009-05-07
20090118556ZEOLITIC CATALYST WITH A CONTROLLED DOPING ELEMENT CONTENT, AND IMPROVED PROCESS FOR PROCESSING HYDROCARBON FEEDS - The present invention concerns doped catalysts on a mixed zeolite/alumino-silicate support with a low macropore content, and hydrocracking/hydroconversion and hydrotreatment processes employing them. The catalyst comprises at least one hydrodehydrogenating element selected from the group formed by elements from group VIB and group VIII of the periodic table and a doping element in a controlled quantity selected from phosphorus, boron and silicon, and a support based on zeolite Y defined by a lattice parameter a of the unit cell in the range 24.40×102009-05-07
20090118557Dehydrogenation of alkyl aromatics - Dehydrogenation of a reactor system of one or more vertically oriented flow reactors equipped with a system for introducing a catalyst extender into the inlet of the reactor. A vertically oriented radial flow reactor comprises inner and outer reactor tubes having perforated wall members extending longitudily of the reactor and defining an annulus containing a dehydrogenation catalyst. A supply line to the reactor is equipped with a rotation vane. An injection nozzle comprising a coaxial flow tube extends into the supply line downstream of the vane. The coaxial flow tube has an interior chamber and an annular chamber surrounding the interior chamber and extending into the supply line along with the interior chamber. The interior chamber is connected to a catalyst extender source and the annular chamber is connected to a source of a carrier gas which is effective to disperse the extender within feedstock flowing into the reactor.2009-05-07
20090118558Dehydration Process - A process for producing an olefin and/or an ether is described, which comprises heating an alcohol in the presence of an acidic ionic compound which exists in a liquid state at a temperature of below 150° C.2009-05-07
20090118559Oxidic Metal Composition, Its Preparation And Use As Catalyst Composition - Oxidic composition consisting essentially of oxidic forms of a first metal, a second metal, and optionally a third metal, the first metal being either Fe or Zn and being present in the composition in an amount of from about 5 to about 80 wt %, the second metal being Al and being present in the composition in an amount of from about 5 to about 80 wt %, the third metal being selected from the group consisting of Mo, W, Ce, and V, and being present in an amount of from 0 to about 17 wt %—all weight percentages calculated as oxides and based on the weight of the oxidic composition, the oxidic composition being obtainable by (a) preparing a physical mixture comprising solid compounds of the first, the second, and the optional third metal, (b) optionally aging the physical mixture, without anionic clay being formed, and (c) calcining the mixture. This composition is suitable for use in FCC processes for the reduction of SO2009-05-07
20090118560Nuclear waste removal system and method using wet oxidation - Methods for removing nuclear waste from a component are provided. In one embodiment, the method includes the steps of supplying oxalic acid to the nuclear waste on the component to form an oxalic acid/waste solution, feeding the oxalic acid/waste solution from the component, feeding an oxidant to the oxalic acid/waste solution to form carbon-dioxide, water and a precipitate, and separating the precipitate from the water. A system for removing nuclear waste is also provided.2009-05-07
20090118561Method for Gasification of Carbonic Materials Using CO2 and Apparatus for Performing Same - A method for gasification of carbonic materials using CO2009-05-07
20090118562DECONTAMINATING SHEET MATERIAL CONTAINING REACTIVE NANOCRYSTALLINE PARTICLES AND PRODUCTS CONSTRUCTED THEREFROM - The invention provides a sorptive sheet material in which finely divided nanocrystalline particles that react with a variety of chemical and/or biological agents are dispersed. The sheet material comprises a fibrous web that is formed of a plurality of fibers that are bonded to each other. The fibrous web contains a relatively high concentration of reactive nanocrystalline particles that are entrapped within the matrix of the fibrous web. Fluids containing toxic agents, such as chemical and/or biological agents, odors and/or odor causing compounds, and toxic industrial compounds, pass into the web and contact the reactive nanocrystalline particles contained therein. The reactive nanocrystalline particles react with, and chemically alter or inactivate the toxic agents. The sorptive sheet material may be used to construct containers, such as remains pouches, for the storing and transporting of contaminated items, particularly human remains.2009-05-07
20090118563SYSTEM AND METHOD FOR TREATING ASBESTOS - A method, apparatus, and system to apply a mineralizing agent to an asbestos containing material (ACM) after the ACM is reduced in size, particularly by spraying or injecting the mineralizing agent to a shredded ACM, is provided. The mineralizing agent may include a solution of alkali metal hydroxide, alkali metal silicate, alkali metal borate, alkaline earth borate, or mixtures thereof, which may be heated and mixed and is then delivered to the reduced size or shredded ACM using a piping system that injects the mineralizing agent downstream of an ACM shredding unit. The ACM treated with the mineralizing agent may be heated in a mineralizing furnace to convert the ACM to an essentially asbestos-free mineral. After removal from the mineralizing furnace, the mineralized material is moved to an atmosphere controlled environment where it is cooled gradually for further mineralization.2009-05-07
20090118564Method for Stabilization and/or Fixation of Leachable Metals - Methods for treatment a heavy metal-contaminated solid, semi-solid, liquid or gaseous matrix with magnesium oxide, magnesium sulfite, magnesium sulfate, magnesium chloride, magnesium hydroxide, and mixtures of any two or more of these. Methods for treatment of a solid or semi-solid waste containing unacceptable levels of leachable aluminum and reactive metallic aluminum-containing waste with magnesium oxide, magnesium sulfite, magnesium sulfate, magnesium hydroxide, magnesium chloride, and mixtures of any two or more of these.2009-05-07
20090118565METHOD IN CONNECTION WITH STEEL PRODUCTION - The invention relates to a method in connection with steel production for handling of hydroxide sludge formed in the neutralization of spent metal-contaminated pickling agents from a pickling step for steel, preferably stainless steel and for using calcium fluoride in the hydroxide sludge to replace the natural fluorspar as a fluxing agent in connection with steel production. Accordingly, the addition of the reactive neutralization medium is monitored by the pH electrodes operated in continuous fashion, and the pH value is adjusted at the range between 9.0 and 9.5.2009-05-07
20090118566SYSTEM AND METHOD FOR ACCELERATING THE CONVERSION OF ASBESTOS IN THE PROCESS OF MINERALOGICAL CONVERSION - A process and equipment that accelerates the rate at which asbestos is converted into non-asbestos minerals during the process of mineralogical conversion, the process consisting of new methods and equipment for handling the asbestos that promotes absorption of mineralizing agents, increases the heat transfer properties of the asbestos, increases the overall efficiency of the process, and shortens the period of time required for processing.2009-05-07
20090118567PURGE-FREE MINIATURE ROTARY PUMP - Methods and systems are provided for the circulation of blood using a purge-free miniature pump. In one embodiment, a pump is provided that may comprise a housing including a rotor and a stator within a drive unit. In this embodiment, the pump may establish a primary blood flow through the space between the drive unit and the housing and a secondary blood flow between the rotor and stator. In another embodiment, a method is provided for introducing the pump into the body and circulating blood using the pump.2009-05-07
20090118568Implantable counterpulsation cardiac assist device - A hollow tubular element is inserted in the descending aorta. The caudad end contains a pressure sensitive passive or preferably, hydraulically or electrically activated, unidirectional valve. A flexible diaphragm situated in a rigid shell affixed over an opening in the element wall divides the shell interior into first and second variable volume chambers. The first chamber opens to the artery. A continuously operating electrical pump is connected to the second chamber through a closed hydraulic system including a multi-valve chamber. The valves regulate fluid flow to the second chamber in accordance with electrical signals from the heart. Fluid flow is directed to the second chamber during cardiac diastole and away from the second chamber during cardiac systole, causing the device to function in a counterpulsation mode. The work of the heart is decreased and coronary blood flow is increased to promote the formation of new coronary collateral channels and the perfusion of the heart itself. In the event of mechanical failure, pre-implantation heart function is not impeded.2009-05-07
20090118569Premixed Counseling and Sound Therapy Matrix For Single Media Players - A matrixed and premixed counseling and sound therapy program format for single media players, which provides, and enables user-selection among, a multiplicity of differing music or other sound therapy tracks each separately premixed with a common, or substantially equivalent or redundant counseling track. The system may be applied to more than one substantially different counseling program each based on a common redundant counseling track. The program format is applicable to a diversity of therapeutic, self-improvement, training and educational programs.2009-05-07
20090118570Apparatus and method for minimally invasive implantation of heart assist device - A method and related apparatus for the minimally invasive implantation about a heart of at least a deployable device such as a heart assist device or cardiac compression device. The method comprises the steps of performing a left thoracotomy or subxiphoid incision; obtaining access to the pericardial sac; making a generally linear incision in the pericardial sac; positioning an assembly having an insertion aperture member with an upper ring and a lower ring or flange and insertion tube having therein a deployable device. The apparatus of the present invention includes an insertion aperture member having an upper ring and a lower ring or flange; and an insertion tube having therein a deployable device adapted to be deployed from the insertion tube inside the pericardial sac via a generally linear incision.2009-05-07
20090118571METHOD AND IMPLANT FOR CURING CYSTOCELE - An implant for the treatment of cystocele, having a thin and supple structure, comprises a support body (2009-05-07
20090118572Controllable gastric band - The invention relates to an adjustable stomach band with a rigid back and a chamber, arranged on the stoma side of the back, for control of stoma constriction by means of introduction or removal of fluid from the chamber. According to the invention, such a stomach band with a preferably automatic setting of the stoma constriction, depending on the food intake, is possible, whereby a second chamber is provided to the stoma side of the back, directly connected to, or cooperating with the first chamber, such that the control of the stoma constriction is achieved by means of displacing the fluid between the chambers or between a reservoir and the stoma-constricting chamber. An auto-regulation can be achieved, whereby a second chamber is embodied as sensor for recording a pressure rise in the stomach and the control of the stoma constriction is achieved depending on the recorded pressure by means of displacement of the fluid from the chamber, or from the reservoir into the stoma-constricting chamber.2009-05-07
20090118575ENDOSCOPIC SYSTEM, TREATMENT SECTION OPERATION CHECK INSTRUMENT FOR THE SAME, AND TREATMENT SECTION OPERATION CHECK METHOD - An endoscopic system includes an endoscope, a cartridge, and a treatment section operation check instrument. The endoscope includes a treatment instrument channel. The cartridge stores a treatment section and a treatment instrument insertion portion introduced into the treatment instrument channel. The treatment section operation check instrument includes a chamber. The chamber contains a hollow section with the volume which allows the treatment section stored in the cartridge to perform a treatment operation. The treatment section operation check instrument is disposed between the endoscope and the cartridge so as to be allowed to perform the operation check by disposing the treatment section in the hollow section of the chamber before insertion of the treatment section into the treatment instrument channel.2009-05-07
20090118576Portable medical apparatus storage holder and capsule endoscope medical care system - An object of the invention is to eliminate unstable behavior of a drawn cable connected to a portable medical apparatus, which is of a storage target, to prevent cable jam or looseness and cable disconnection. A bundling member (2009-05-07
20090118577MEDICAL DEVICE MADE WITH A SUPER ALLOY - A medical device with a shaft having a proximal end and a distal end, the proximal end having an operational interface, the distal end having a working element, and the shaft may include a super alloy. In one example embodiment, the shaft may include a cobalt base alloy. In another example embodiment, a medical device includes a first portion having a super alloy, and a second portion having a dissimilar metal joined to the first portion by an arc welding technique. In another possible embodiment, a first portion includes a cobalt base alloy, and a second portion includes a non-metal joined to the first portion. The inventive subject matter also includes a method for joining a cobalt base alloy to a dissimilar metal by hermetic sealing, such as provided, for example, by an arc welding technique.2009-05-07
20090118578ENDOSCOPE APPARATUS AND IMAGE PROCESSING APPARATUS - A normal light CCD 2009-05-07
20090118579MEDICAL CAPSULE - A medical capsule having a capsule configuration of size permitting introduction in a body, adapted to be at least partially dissolved over time by remaining in the intestines for a predetermined time or more. The medical capsule includes an inner casing provided at both ends with a discharge outlet and, surrounding the periphery thereof, an outer casing with a substantially uniform thickness. The inner casing and the outer casing are made of a material dissolved in the digestive secretion of the intestines. When the medical capsule remains in the intestines by, for example, entering a narrow area of the intestines, the wall of the outer casing begins to be dissolved. By this dissolution, the inner space of the inner casing communicates through the discharge outlet with the outside of the medical capsule. Consequently, a filling, such as a dye, medicine, etc., of the inner casing flows into the intestines.2009-05-07
20090118580Image-type intubation-aiding device - An image-type intubation-aiding device comprises a small-size image sensor and a light source module both placed into an endotracheal tube to help doctors with quick intubation. Light from light emission devices in the light source module passes through a transparent housing and is reflected by a target and then focused. The optical signal is converted into a digital or analog electric signal by the image sensor for displaying on a display device after processing. Doctors can thus be helped to quickly find the position of trachea, keep an appropriate distance from a patient for reducing the possibility of infection, and lower the medical treatment cost. Disposable products are available to avoid the problem of infection. The intubation-aiding device can be used as an electronic surgical image examination instrument for penetration into a body. Moreover, a light source with tunable wavelengths can be used to increase the spot ratio of nidus.2009-05-07
20090118581METHOD FOR ACTIVATING AN IMAGE COLLECTING PROCESS - A method and system may activate an in-vivo capsule to perform image collection while the capsule is outside a body and held in a cup, the cup having a mark on its inner wall. A processor may attempt to identify the mark, and terminate the image collection if the mark is not identified2009-05-07
20090118582MEDICAL INSTRUMENT, ENDOSCOPE AND ENDOSCOPE DEVICE - A medical instrument of the present invention comprises a spiral shaped portion provided at an insertion portion main body, for generating a force at the insertion portion main body to advance/retreat in a subject by a contact with a body wall of the subject, a balloon provided so as to expand radially in a radial direction of the insertion portion main body and capable of contact with the body wall, a suction opening portion provided between the spiral shaped portion and the balloon in the insertion portion main body, and a suction pipeline communicating with the suction opening portion, inserted into the insertion portion main body and connected to a suction pressure controller on a rear end side of the insertion portion main body in the insertion direction.2009-05-07
20090118583SWITCHING MECHANISM FOR ALTERING OPERATION WITH LIGHT - A switching mechanism is used for altering the operation of an electronic device. The switching mechanism has a memory comprising a plurality of memory cells. Each memory cell undergoes a change in binary data upon receiving more than a specific amount of light having a specific wavelength. The operation is altered when the binary data of at least one memory cell of the plurality of memory cells is changed by the light.2009-05-07
20090118584INSERTION TUBE FOR ENDOSCOPE AND ENDOSCOPE - An insertion tube for an endoscope includes a braid tube, the braid tube includes fine line portions arranged in a braided manner and intersecting portions where the fine line portions intersect with each other, and the fine line portions is restricted with each other in the intersecting portions.2009-05-07
20090118585BODY-INSERTABLE APPARATUS - In a capsule casing 2009-05-07
20090118586Surgery accessory and method of use - In laparoscopic or thorascopic surgery, a trocar is used to provide an passage into the body cavity of a patient for injecting an inert gas to inflate it. A laparoscope or thorascope is passed through a sealing membrane of the trocar so the patient may be observed without releasing a large quantity of the inert gas. If the scope lens is clouded with body liquids or tissue, the scope is removed from the trocar and its lens cleaned. The trocar cannula is cleaned by running a swab through the sealing membrane into the cannula and removing body liquids, tissue and/or check valve lubricant from the inside of the cannula. The swab includes radiopaque markers on the sorbent end, measuring marks on the swab handle and an enlargement on the swab handle. The enlargement is positioned so it may be grasped and the swab pushed into the cannula a distance which is insufficient to push the sorbent end out of the end of the cannula.2009-05-07
20090118587Manifold for laparoscopic seal assembly - A laparoscopic seal assembly includes a seal cap having a seal with an access opening. The seal cap also includes a manifold connection for attachment of a functional apparatus. The seal assembly further includes a retractor.2009-05-07
20090118588Method and system for providing adaptive rule based cognitive stimulation to a user - A method and system for providing evolving, highly variable, long-term on-going cognitive stimulation over a broad spectrum of cognitive domains. The user is presented with a series of entertaining audio/visual activities customized for the user, based on the user's life experience and cognitive level, each activity providing stimulation in one or more cognitive domains. The activities themselves and their level of challenge may change, in real time, over both the short- and the long term, varying in relation to current and historical user response patterns, creating an experience that remains engaging, with on-going use, over a period of months or years.2009-05-07
20090118589HEALTH MANAGEMENT SUPPORT SYSTEM AND RECORDING MEDIUM - A health management support system capable of showing the change in biometric information in a form which can be easily understood is provided. The health management support system includes: a storage unit for storing a measurement value of biometric information such as a body weight in association with the measurement date; a symbol assignment processing unit for calculating a change tendency of measurement values of the biometric information stored over a plurality of periods each of which consists of previous days including a predetermined measurement day as the last day of the each period and assigning one of arrow symbols 2009-05-07
20090118590MULTI-SENSOR SYSTEM, DEVICE, AND METHOD FOR DERIVING HUMAN STATUS INFORMATION - The invention is a wireless communications device, such as a cellular telephone, having sensors to generate data indicative of a physiological or contextual parameters of a user. A processor on the wireless communications device is adapted derive physiological state information of the user from the contextual or physiological parameters. The apparatus may include a central monitoring unit remote from the sensors for storing data and transmitting data to a recipient.2009-05-07
20090118591METHOD AND APPARATUS FOR COLLECTING DATA FROM HOUSEHOLD MEDICAL DEVICES - Disclosed is a communication protocol for collecting data from household medical devices, the protocol including the steps of: transmitting an initialization packet in order to detect a household medical device capable of communication, and receiving a reply packet including device type/id information from the device; asking the device for a number of stored data items, and receiving a reply; and asking the device for measurement data, and receiving at least one data item from the device, wherein each of the packets for the communication includes a plurality of fields including start code, size, command, device type, device id, and checksum. Accordingly, in data exchange between a Home gateway and a household medical device, a compatible protocol is employed, so that the Home gateway can receive measurement data from various types of medical devices, the protocol can be applied to various manufacturers' products, and the protocol has an extensibility of application even to newly developed medical devices in the future, which enables users to easily select medical devices.2009-05-07
20090118592Medical System Comprising a Sensor Device - A medical system is provided comprising a sensor unit and a receiving unit is provided, the sensor unit being adapted to generate sensor data indicative of a time-dependent characteristic of a subject, and transmit data to a receiver at intervals determined by an analysis of time-dependent changes in the generated sensor data, the receiving unit being adapted to receive sensor data at a non-predetermined rate. By this arrangement sensor data can be transmitted only when considered necessary in accordance with a predetermined strategy, this reducing the energy consumption associated with the transmission of data. The strategy may set out that the transmission of sensor data is skipped in case there is no or only a small change in an actual sensor data value. On the other hand, in case of rapid changes in sensor data values, sensor data may be transmitted at higher rate.2009-05-07
20090118593Determining a demographic characteristic based on computational user-health testing of a user interaction with advertiser-specified content - Methods, apparatuses, computer program products, devices and systems are described that carry out specifying at least one of a plurality of user-health test functions responsive to an interaction between a user and at least one advertiser-specified attribute; and transmitting at least one demographic characteristic of the user based on at least one output of the at least one of a plurality of user-health test functions.2009-05-07
20090118594SMART PARENTERAL ADMINISTRATION SYSTEM - The invention provides methods and systems for evaluating a fluid transfer event between a parenteral fluid delivery and a patient. The evaluation of the fluid transfer event can be prospective real-time and/or historic, as desired, and take a variety of different formats.2009-05-07
20090118595SENSOR FOR ACQUIRING PHYSIOLOGICAL SIGNALS OF A PATIENT - The present invention suggests the use of independent, wireless, smart and therefore self-contained sensors (2009-05-07
20090118596Method and Apparatus for Remotely Monitoring the Condition of a Patient - A patient monitoring system provides enhanced functional capability relative to known systems and provides a wireless communication link between a patient monitoring device, worn by a patient, and a local hub. The patient monitoring system is adapted to monitor various patient physiological characteristics, such as blood pressure, pulse rate, blood glucose, weight, pulse oximetry and others. The data from the patient monitoring device is wirelessly transmitted to a local hub, which, in turn, is configured to automatically transfer the data to a remote server, for example, over a public or private communications network. In one embodiment of the invention, the server is configured as a web portal to selectively allow access to such patient physiological data by designated third parties, such as physicians, clinicians, relatives and the patient themselves.2009-05-07
20090118597Neural Signal Processing - A method of monitoring neural signal activity with an implantable monitoring device implanted in a living subject includes amplifying a neural signal having a signal bandwidth of at least 1000 Hz. The method also includes processing the amplified neural signal to produce a reduced-bandwidth derivative neural signal representative of gross activity of the neural signal, and wirelessly transmitting the derivative neural signal from the implantable monitoring device for receipt by a receiver external of the living subject.2009-05-07
20090118598MEDICAL SENSOR AND TECHNIQUE FOR USING THE SAME - A sensor may be adapted to provide output to indicate when the sensor experiences abnormal forces or pressure. The forces may be outside forces, or the forces may be generated by patient motion. A sensor system as provided may also be adapted to correct for such forces when calculating measurements related to a physiological characteristic.2009-05-07
20090118599COLLECTING ACTIVITY AND SLEEP QUALITY INFORMATION VIA A MEDICAL DEVICE - A device, such as an implantable medical device (IMD) or a programming device, determines when a patient is attempting to sleep. When the device determines that the patient is attempting to sleep, the device determines values for one or more metrics that indicate the quality of a patient's sleep based on at least one physiological parameter of the patient. When the device determines that the patient is not attempting to sleep, the device periodically determines activity levels of the patient. Activity metric values may be determined based on the determined activity levels. A clinician may use sleep quality information and patient activity information presented by a programming device to, for example, evaluate the effectiveness of therapy delivered to the patient by the medical device.2009-05-07
20090118600METHOD AND APPARATUS FOR SKIN DOCUMENTATION AND ANALYSIS - A system and method for documentation and analysis of dermatological aspects of a human body. The system has a predetermined arrangement of at least three image sensors selected from visible light sensors, ultraviolet (UV) light sensors, infrared (IR) sensors. Each of the image sensors has an effective normalized focal length of from about 8 to about 28 millimeters, an aperture stepped-down to at least f/4 or higher F-stop, and a shutter exposure length of no longer than about 125 milliseconds. Output from the image sensors provide a single relatively high resolution image of a skin surface of the human body obtained from a distance of at least about 0.1 meters. A data collection and processing system is integrated with the image sensors to provide storage, analysis, and output of in-situ dermatological information to a system operator.2009-05-07
20090118601IR SPECTROGRAPHIC APPARATUS AND METHOD FOR DIAGNOSIS OF DISEASE - A method for detecting disease in a patient includes providing infrared (IR) light and coupling the IR light through direct lens coupling or through a first group of one or more optical fibers. IR light is reflected from a portion of the patient and collected by a lens arrangement or a second group of one or more optical fibers. The reflected IR light is dispersed into its spectrum which is detected and analyzed. An apparatus suitable for diagnosing a disease in a patient includes an IR light source and optical fiber or direct lens coupling of IR light onto a body part or fluid of the patient. Reflected light from the patient is optically dispersed using a prism or grating. An IR focal plane array receives the optically dispersed light. The spectrum of the reflected IR light is used to provide a diagnosis of disease in the patient by identifying various disease markers or chemical fingerprints. The method and apparatus are capable of non-invasively detecting disease markers in a patient.2009-05-07
20090118602Disease Diagnosis Support System - There is provided a system for supporting the assessment as to which disease group the subject to be examined falls in or what position in the whole disease group the subject is in. This support system comprises the data storage part which stores feature values of optical bio-measurement data of many subjects including patients in multiple disease groups, the analysis part which extracts plural kinds of feature values from the optical bio-measurement data and the display part which displays the results of analysis in the analysis part associated with the dictionary data, wherein the display part produces a scatter diagram on which features values of the dictionary data are plotted, with one of the two feature values being plotted along the axis of abscissa and the other along the axis of ordinate, and displays the positions of the subject to be assessed on the scatter diagram superimposed on the scatter diagram. With this scatter diagram, the relationship between the features of the subject and the feature of the disease group can be known in one glance.2009-05-07
20090118603OPTICALLY ALIGNED PULSE OXIMETRY SENSOR AND TECHNIQUE FOR USING THE SAME - A physiological sensor is provided that includes an emitter and detector disposed on a frame such that the emitter and detector define an optical axis. The frame includes one or more pair of flexible elements disposed generally symmetric relative to the optical axis. In one embodiment, the emitter and detector remain aligned when moved relative to one another along the optical axis.2009-05-07
20090118604ANALYTE MONITORING SYSTEM HAVING BACK-UP POWER SOURCE FOR USE IN EITHER TRANSPORT OF THE SYSTEM OR PRIMARY POWER LOSS - An analyte monitoring system includes a biosensor for detecting an analyte concentration in blood. The monitoring system includes first and second power sources, each selectively couplable to the biosensor for providing power to the biosensors. A sensor may be associated with the first power source and senses the output thereof. A selector is coupled to both the first and second power sources and the biosensor, such that it may selectively couple an output or outputs of either the first or second power sources to the biosensor. In operation, the first power source is coupled to the biosensor to thereby bias the sensor. If the sensor indicates that the first power source is not providing power to the biosensor, the selector decouples the first power source from the biosensor and couples the second power source to the biosensor to thereby maintain the biosensor in a biased state.2009-05-07
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