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19th week of 2009 patent applcation highlights part 46
Patent application numberTitlePublished
20090118099CLOSED-LOOP POWER DISSIPATION CONTROL FOR CARDIO-FITNESS EQUIPMENT - Various embodiments of the present invention provide (a) an inexpensive apparatus enabling the measurement of power dissipated by the rider of a cardio-fitness station (or any other stationary bicycle) that does not depend on manufacturing tolerances or machine condition variations, and (b) a method of using the data measured by such an apparatus to improve the accuracy of exercise condition settings by implementing the invented apparatus into a closed-loop control system which improves the quality of the exercise experience and enhances the adoption of exercise on a cardio-fitness station employing this as a community activity.2009-05-07
20090118100MOBILE EXERCISE ENHANCEMENT WITH VIRTUAL COMPETITION - A glanceable interface presented by a computing device to a user while the user engages in physical exercise can provide information regarding exercise-related data within the context of the user's exercise-oriented goals. In particular, the glanceable interface can display the difference between a user's current exercise level and a target level, optionally with instructions how to reach the target level. Once the target level is reached, the glanceable display can provide raw exercise-related data to the user. In addition, virtual competition can be based on a target-achievement-score that is based on the amount of time, and the accuracy with which, a competitor maintains their exercise level within a target exercise level zone. Competitors can be automatically selected based on the closeness of their target-achievement-scores to the user's target-achievement-score, so long as at least one competitor has a higher target-achievement-score than the user so as to further motivate the user.2009-05-07
20090118101Practice Samurai Sword - A practice sword simulating a Katana. The practice sword provides an affordable, safe practice weapon that correctly simulates the size, weight and curve of the Japanese sword with both simulated cutting and thrusting capabilities. The practice sword includes generally a handle, a handle guard, and a simulated blade. The blade is comprised of a plurality of flexible limbs. The limbs are interconnected at a proximal end, proximate the handle and handle guard. The distal end of each limb is limited to axial movement with respect to each other limb. The blade includes a plurality of flexible limbs. The proximal end of each flexible limb is fixed relative to each other proximate the handle guard. The distal end of each flexible limb is limited to axial movement with respect to each other flexible limb.2009-05-07
20090118102TRAINING APPARATUS FOR SKATING-TYPE SPORTS - A training apparatus configured for skating-type sports whereon a user can perform training, exercising, strengthening and conditioning while wearing footgear designed for use in skating-type sports. The training apparatus comprises a pair of interconnected opposed matching elongate platforms extending backward and away from each other preferably at an angle equal to or less than 90°. Each platform is provided with an abrasion-resistant exercise surface assembly configured to slidingly communicate with and to controllably engage and disengage a user's footgear. Each platform is provided with a controllably pivotable and lockable foot stop assembly. The training apparatus is provided with an electronic device configured to measure, monitor, record and report at least one of a user's vital signs and a physical performance criterion associated with skating-type motions and activities. The training apparatus is optionally provided with a vertically adjustable knee brace apparatus.2009-05-07
20090118103DUAL DIRECTION EXERCISE TREADMILL FOR SIMULATING A DRAGGING OR PULLING ACTION WITH A USER ADJUSTABLE CONSTANT STATIC WEIGHT RESISTANCE - An exercise treadmill having an endless moveable surface looped around rollers or pulleys to form an upper run and a lower run, the movable surface being rotated when one of the rollers or pulleys is rotated, and an exercise surface for walking or running while exercising, a weight resistance mechanism for providing a weight resistance for simulating the dragging or pulling of a load, wherein the weight resistance can be adjusted and set to a specific weight resistance setting; a movable hand controller operatively attached to the weight resistance mechanism for operating and controlling the exercise treadmill and the weight resistance mechanism, wherein the endless movable surface moves in a direction simulating walking or running backwards, and wherein the weight resistance mechanism applies a constant and static force to the hand controller generally only in the same as the direction the endless movable surface moves and opposite a pulling direction, whereby operation of the treadmill simulates the dragging or pulling of a load by a combination of the actuation of the weight resistance mechanism to simulate the load and the walking or running backwards to provide the dragging or pulling action.2009-05-07
20090118104AB-Exerciser bench - An abdominal muscle exercise machine that generally contains a diagonal member with an adjustable seat and a backrest and a pivot member that pivots with respect to the diagonal member. A chest push can be mechanically coupled to the pivot member through an adjustable force multiplier. An optional counterweight can be placed near one end of the pivot member to lighten the force, or an optional load weight can be placed near the other end of the pivot member to increase the force. The pivot member can be constructed to telescope or otherwise adjust for different body sizes. The machine provides a smooth exercise where the top and bottom portions of the body move together in a linked fashion. The machine of the present invention works without heavy external weights.2009-05-07
20090118105ADJUSTABLE-WEIGHT EXERCISE APPARATUS AND METHOD - An adjustable-weight exercise apparatus include a rod with opposing end sections defining bearing surfaces, a first shallow channel without ribs, and a second shallow channel with ribs. The weights each include a hub shaped to telescopingly slide onto ends of the rod. Each hub further includes opposing flexible fingers with tips configured to slide along the second shallow channel when in a first rotational orientation during assembly of the weights onto the rod, and configured to flex over a raised detent into engagement with the second shallow channel between the ribs when the weight is rotated.2009-05-07
20090118106Exercise machine - An exercise machine includes manually grasped and displaced levers and includes bracket assemblies adjustable to permit the levers to engage the levers and enable each lever individually and independently to be manually pulled or pushed. An elastic operably associated with each bracket provides resistance and returns each bracket to a stored at rest position after a manual displacement force on the bracket is released.2009-05-07
20090118107Reaction Training Belt With Variable Release Resistance - A cost effective training belt that offers the ability to vary the release resistance and that allows the release resistance to remain relatively constant throughout the life of the belt. In one disclosed embodiment, the reaction belt has a first and second belt detachably secured together with a detaching structure that can connect the first and second belts together in at least two different ways. Each of the connecting ways offers a different release resistance; thereby a user can select the desired release resistance by selecting which way to connect the two belts together.2009-05-07
20090118108Exercise apparatus with a pull cord central pulley attached to a carriage and a pulley locking mechanism - An exercise apparatus including a frame, a carriage, a central pulley, first and second frame pulleys, a pull cord, and a locking mechanism. The frame defines a longitudinal axis. The carriage is mounted on the frame and movable along the longitudinal axis. The central pulley is attached to the carriage. The first and second frame pulleys are attached to the frame. The pull cord has first and second handle portions. The pull cord is looped about the pulleys. The central pulley is between the first and second frame pulleys along the pull cord. The first frame pulley is between the first handle portion and the central pulley along the pull cord. The second frame pulley is between the second handle portion and the central pulley along the pull cord. The locking mechanism is configured to engage the central pulley.2009-05-07
20090118109VERTICAL FILTER FILLING MACHINE AND PROCESS - Process and apparatus for the mass production of compound cigarette filters function to deposit granular filter material into the open ends of vertically oriented filter tubes. Predetermined amounts of diverse granular material are withdrawn by suction from sources of such material, and these amounts are deposited into the tubes. Solid filter segments seal the granular material within the tube. After one half of each filter tube is filled with granular material and sealed, the tube is inverted and the opposite end is filled in substantially the same manner. When cut in half each filter tube produces two cigarette filters.2009-05-07
20090118110Flexible Vase With Integral Label and a Method for Its Manufacture - The present invention provides an article of manufacture formed from a sheet material. The article has a collapsed vase portion and a label portion integral with the vase portion. The vase portion and the label portion have a common boundary, and when the label portion is detached from the vase portion is detached from the vase portion, the vase portion forms a flexible vase. In a preferred embodiment, the boundary is a weakened region in the sheet material, so that the label portion may be detached from the vase portion by tearing the label portion off from the vase portion along the weakened boundary. The invention also provides a method for manufacturing the article of manufacture of the invention, as well as a method for using the article of manufacture.2009-05-07
20090118111Impulse Centrifuge for the Purification of the Lubricating Oil from an Internal Combustion Engine - A free-jet centrifuge for the cleaning of lubricating oil comprising, a housing with a removable cover, a rotor rotatable arranged in the housing and with channels for feeding and removing the lubricating oil. The rotor is of split design with a drive part and a dirt trapping part which can each be flowed through by their own partial lubricating oil flow and which are designed with torque transmission means which are engageable and disengageable. The dirt trapping part is separable from the drive part. Means are provided to prevent or restrict the axial mobility of the dirt trapping part relative to the drive part, which are ineffective or detachable when the cover is removed. The drive part extends from the bottom towards the top into the dirt trapping part or entirely through it. The drive part comprises all parts serving for the rotatable bearing of the rotor and the drive part is securely positioned against axial removal with an opened cover.2009-05-07
20090118112LIQUID DELIVERY APPARATUS AND LIQUID DELIVERY METHOD - A chamber chip 2009-05-07
20090118113CRYSTALLIZED GLASS - In all of an in-plane magnetic recording system and a perpendicular magnetic recording system, there is provided a crystallized glass for a disk substrate for information recording medium, etc., which has satisfactory surface properties capable of sufficiently adapting with a lamp loading system for high-density recording, has high strength such that it is able to withstand high-speed rotation and impact, has heat expansion properties and heat resistance in agreement with respective drive members, has a low melting temperature, has excellent productivity and is reduced in the elution amount of an alkali from the raw material, namely excellent in chemical durability. The crystallized glass of the invention is a crystallized glass containing an SiO2009-05-07
20090118114Bioactive graded zirconia-based structures - The present invention provides a functionally graded bioactive glass/ceramic composite structure or bioactive glass/ceramic/bioactive glass sandwich structure for use in such applications as damage resistant, ceramic dental implants, immediate tooth replacement, endodontic posts, orthopedic prostheses, orthopedic stems, bone substitutes, bone screws, plates, and anchors, nonunion fractures repair, alveolar ridge augmentation, missing small bone parts (e.g. fingers, toes, etc), maxilla facial reconstruction, spinal fusion, and scaffolds for bone regeneration, comprising a residual bioactive glass or glass-ceramic layer at all accessible surfaces, followed by an underlying graded glass-ceramic layer, and then an dense interior ceramic. The residual bioactive glass or glass-ceramic layer can be further transformed to a carbonate apatite (CHA) layer by immersing in calcifying solution or simulated body fluid (SBF) with electrolyte composition similar to that of serum. The interior ceramic preferably contains yttria-tetragonal zirconia polycrystal (Y-TZP) or ceria stabilized tetragonal zirconia polycrystal (Ce-TZP) or magnesia stabilized zirconia (Mg-PSZ) or calcia stabilized zirconia (Ca-PSZ) or alumina or zirconia-alumina composites. Further, the invention provides methods for making the same functionally graded bioactive glass/ceramic composite structure or graded bioactive glass/ceramic/bioactive glass sandwich structure.2009-05-07
20090118115USE OF TIO2 RESIDUES FROM THE SULFATE PROCESS2009-05-07
20090118116Catalyst and Method of Manufacturing the Same - A method of manufacturing a catalyst by suspending a titanium-containing silicate porous material in a solution with a metal salt being dissolved therein, and then by exposing the solution to ultra violet light to precipitate metal fine particles on the surface of the porous material.2009-05-07
20090118117SOLVENT, ADDITIVE AND CO-CATALYST EFFECTS FOR ETHYLENE OLIGOMERIZATION CATALYSIS - The invention is directed to catalyst systems for the oligomerization of ethylene. In some embodiments, the catalyst system includes ethylene, a solvent, and a catalyst activated with an aluminoxane co-catalyst. The system may further include an additive. Various modifications to the different reaction parameters may be made to fine-tune the reaction properties, such as productivity, activity and selectivity for a particular oligomer. For example, the solvent may be modified to include a mixture of at least two solvents. Alternatively, the co-catalyst may be modified by aging or partially fluorinating the co-catalyst. In another alternative, an additive may be included in the reaction system. Each modification to the reaction system effects a different reaction outcome, thereby enabling fine-tuning of the reaction properties by varying the modifications to the reaction system.2009-05-07
20090118118Self Limiting Catalyst Composition and Propylene Polymerization Process - A catalyst composition for the polymerization of propylene comprising one or more Ziegler-Natta procatalyst compositions comprising one or more transition metal compounds and one or more esters of aromatic dicarboxylic acid internal electron donors; one or more aluminum containing cocatalysts; a selectivity control agent (SCA) comprising at least one silicon containing compound containing at least one C2009-05-07
20090118119WATER GAS SHIFT CATALYST - A water gas shift catalyst comprising a precious metal deposited on a support, wherein the support is prepared from a mixture comprising a low surface area material, such as an aluminate, particularly a hexaaluminate, and a high surface area material, such as a mixed metal oxide, particularly a mixture of zirconia and ceria, to which may be added one or more of a high surface area transitional alumina, an alkali or alkaline earth metal dopant and an additional dopant selected from Ga, Nd, Pr, W, Ge, Au, Ag, Fe, oxides thereof and mixtures thereof.2009-05-07
20090118120SOLID MATERIALS FOR REMOVING ARSENIC AND METHOD THEREOF - Solid materials have been developed to remove arsenic compounds from aqueous media. The arsenic is removed by passing the aqueous phase through the solid materials which can be in molded, granular, or powder form. The solid materials adsorb the arsenic leaving a purified aqueous stream. The materials are aerogels or xerogels and aerogels or xerogels and solid support structure, e.g., granulated activated carbon (GAC), mixtures. The species-specific adsorption occurs through specific chemical modifications of the solids tailored towards arsenic.2009-05-07
20090118121Exhaust Emission Control Catalyst and Exhaust Emission Control System - PM is more securely restrained from adhering to and depositing on an exhaust gas inlet part of an exhaust emission control catalyst while avoiding disadvantages of lowering in purification performance and strength.2009-05-07
20090118122ENETRANT TRANSFER PRINTING - A penetrant transfer printing method includes the step of: providing an object with a printing layer thereon, and then providing a colorless surface material on the printing layer of the object for baking to form a protective film on the printing layer of the object, and then attaching a transfer paper on the printing layer of the object for hot pressing the transfer paper. The protective film will form pores therein because of expansion of a molecule structure, and a printing ink of a pattern on the transfer paper will be molten and penetrate into the pores of the protective film to transfer the pattern of the transfer paper to the printing layer of the object. Last step of the present is peeling the transfer paper off and clearing the object.2009-05-07
20090118123HERBICIDAL COMPOSITIONS FOR TOLERANT OR RESISTANT SUGAR BEET CROPS - Suitable for controlling harmful plants in sugar beet crops composed of tolerant or resistant mutants or transgenic sugar beet plants are herbicide combinations (A)+(B), if appropriate in the presence of safeners, with an effective content of 2009-05-07
20090118124NOVEL AQUEOUS COMPOSITION AND USE OF THE SAME - An aqueous composition containing a single compound of a ferrosoferric salt as the active ingredient. The composition has many uses, including use as a rust preventative.2009-05-07
20090118125Water Dispersible Agricultural Chemical Granules and Method of Producing the Same - A water dispersible agricultural chemical granule having good productivity and dispersion stability in water and a method of producing the same are provided. A water dispersible agricultural chemical granule produced by spray drying after wet pulverization of a suspension containing an agricultural chemical active component having a melting point ranging from 55 to 100° C., a surfactant and water, with a drying loss of the water dispersible agricultural chemical granule ranging from 0.1 to 5.0% by mass. A method of producing a water dispersible agricultural chemical granule including spray drying after wet pulverization of a suspension containing an agricultural chemical active component having a melting point ranging from 55 to 100° C., a surfactant and water so as to obtain the water dispersible agricultural chemical granule having drying loss ranging from 0.1 to 5.0% by mass.2009-05-07
20090118126SUPERCONDUCTOR INDUCTION COIL - An induction heating apparatus that can operate at current frequencies of greater than 60 Hz and at least 1 kW. The induction heating apparatus includes a high frequency power supply, a superconductive induction coil, and a fluid cooling system. A fluid cooling system is designed to cause a cooling fluid to flow at least partially about and/or through the superconductive induction coil.2009-05-07
20090118127Methods for Use in Human-Adapting Monoclonal Antibodies - Methods useful for human adapting non-human monoclonal antibodies are disclosed. The methods select candidate human antibody framework sequences from a database of human germline genes or human sequences with somatic mutations.2009-05-07
20090118128Preparation of templates for nucleic acid sequencing - The invention relates to methods of generating templates for a nucleic acid sequencing reaction which comprise: 2009-05-07
20090118129VIRTUAL READS FOR READLENGTH ENHANCEMENT - Methods arrays and systems that facilitate contig assembly during nucleic acid sequencing are provided. Geographical locations of analyte molecules on an array are correlated with subsequence relationships within larger nucleic acids.2009-05-07
20090118130Structure-activity relationships - The present disclosure relates to compositions and methods for screening a plurality of polypeptide variants.2009-05-07
20090118131Genetic comparisons between grandparents and grandchildren - Displaying a comparison of genotypic information between relatives is disclosed, including receiving an indication that a first individual is a grandparent, receiving an indication that a second individual is a grandchild of the first individual, comparing the genotypic information of the first individual and the second individual and calculating a similarity score, and displaying an indication of the similarity score graphically using colors.2009-05-07
20090118132Classification of Acute Myeloid Leukemia - The present invention relates to rapid and reliable approaches to leukemia prognostication. In addition to methods, the invention also provides related kits and systems.2009-05-07
20090118133BIOLOGICAL DATASET PROFILING OF CARDIOVASCULAR DISEASE AND CARDIOVASCULAR INFLAMMATION - Methods and systems for evaluating biological dataset profiles relating to inflammatory cardiovascular conditions are provided, where datasets comprising information for multiple cellular parameters are compared and identified, and used in the evaluation of candidate pharmacologic agents for suitability as therapeutic agents.2009-05-07
20090118134Template Fixed Beta-Hairpin Loop Mimetics and Their Use in Phage Display - Template-fixed β-hairpin mime tics of the general formula R2009-05-07
20090118135METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS - An assay for determining compounds that inhibit activity of a BCl-2 protein, or affect conversion of Bcl-2 from an antiapoptotic to a proapoptotic form are described. In addition, compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and related Bcl-2 family members are identified.2009-05-07
20090118136ASSAY FOR DETECTING NUCLEOTIDE SEQUENCES IN GENETICALLY MODIFIED CROPS AND PLANTS USING OPTICAL THIN-FILM BIOSENSOR CHIPS - A process for detecting at least one DNA sequence using an optical thin-film biosensor chip includes the steps of placing a sample to be tested in contact with at least one capture probe attached to an optical thin-film biosensor chip; incubating the sample in the presence of an enzyme and a substrate; identifying a change in the color of the sample; and detecting the sample comprises at least one DNA sequence.2009-05-07
20090118137COMPETITIVE OLIGONUCLEOTIDES - The present invention generally relates to competitive oligonucleotides and, in some embodiments, to competitive oligonucleotides for use in comparative genomic hybridization (CGH) and related techniques. One aspect is generally directed to a blocking composition constructed and arranged to be used in an assay of a nucleic acid. The blocking composition may comprise oligonucleotides comprising sequences selected to hybridize to the nucleic acid used in the assay. Another aspect is generally directed to performing CGH assays and similar techniques on genomic DNA, in the absence of a Cot-1 fraction, such that the genomic DNA does not substantially cross-hybridize. Yet other aspects of the invention are directed to devices or kits for making or using competitive oligonucleotides, methods of promoting such competitive oligonucleotides, or the like.2009-05-07
20090118138CELL SENSOR HAVING MULTIFUNCTIONAL REACTIONS FOR THE DEFINITION OF QUALITY CRITERIA DURING THE PRODUCTION OF MATERIALS - Method for producing a cell sensor system for the definition of quality criteria during the production of materials, characterised by the following method steps: 2009-05-07
20090118139Microfluidic method and system for enzyme inhibition activity screening - Methods for screening a compound for enzyme inhibition activity include providing at least one sample mixture to a microfluidic device, applying vacuum pressure to the sample mixture, flowing the sample mixture along a microchannel of the microfluidic device, separating at least two components of the sample mixture based upon a net charge difference between the product and at least one other material to produce separated material, detecting at least one of the separated materials, and determining enzyme inhibition activity based on the detection of the separated material. Kits for screening a compound for enzyme inhibition activity include a first multiwell plate having a specific plurality of enzymes disposed within a first plurality of wells and a second multiwell plate having a plurality of enzyme substrates disposed with a second plurality of wells, a phosphate source and a cofactor disposed within each well of the second plate.2009-05-07
20090118140METHOD AND SYSTEM FOR ASSEMBLY OF MACROMOLECULES AND NANOSTRUCTURES - A template-based system enables the assembly of macromolecules and nanostructures. The template system comprises a plurality of single strand DNA molecules which are substantially parallel, substantially inline each from one end, and substantially equally spaced apart, wherein each DNA molecule has a distinguishable length and a known sequence. The system can be used for the precise, accurate, and efficient synthesis of peptides, proteins and enzymes.2009-05-07
20090118141METHODS OF OLIGOSACCHARIDE PROFILING FOR THE DETECTION OF OCULAR ROSACEA - The present invention provides methods for identifying oligosaccharides specific to an inflammatory or infectious disease, methods for diagnosing an inflammatory or infectious disease by detecting the presence or absence of such oligosaccharides, and methods for treating an inflammatory or infectious disease by administering antibodies directed to such oligosaccharides. The present invention also provides methods for diagnosing ocular rosacea by determining the presence or absence of specific oligosaccharide markers. In addition, the present invention provides markers for ocular rosacea comprising 0-linked oligosaccharides as well as kits for diagnosing or treating ocular rosacea.2009-05-07
20090118142METHOD AND AGENT FOR IMMOBILIZING PROTEIN VIA PROTEIN BOUND TO SILICON OXIDE-CONTAINING SUBSTANCE - Disclosed is a method for immobilizing a target protein to the surface of silicon oxide-containing substance such as glass without modifying the surface of silicon oxide-containing substance by using a protein binding strongly to silicon oxide-containing substance. A protein capable binding strongly to silicon oxide-containing substance such as glass has been found, and thus a target protein can be directly bound and immobilized to the surface of silicon oxide-containing substance via the found protein. In addition, a fusion protein of the found protein and a target protein can be bound and immobilized to silicon oxide-containing substance.2009-05-07
20090118143Methods for Manipulation of the Flow of Fluids in Subterranean Formations - A method of treating a subterranean formation penetrated by a wellbore to mitigate the production of unwanted fluids from the wellbore is carried out by forming a treatment fluid containing at least one of an oil-wetting or water-repelling surfactant and a carrier fluid. The treatment fluid is then introduced into the wellbore. The treatment or treatments may be performed remedially or prophylacticaly. The treatment may include the completion and production of zones containing the undesirable fluid(s) and the deliberate formation of cones therein.2009-05-07
20090118144Methods for Manipulation of Air Flow into Aquifers - A method of treating a subterranean formation penetrated by a wellbore to mitigate the production of unwanted air from the wellbore is carried out by forming a treatment fluid containing a water-wetting surfactant and a carrier fluid. The treatment fluid is then introduced into the wellbore. The treatment or treatments may be performed remedially or prophylacticaly. The treatment may include the completion and production of zones containing the undesirable air and the deliberate formation of cones therein.2009-05-07
20090118145METHOD FOR PRODUCING PROPPANT USING A DOPANT - A method for producing sintered pellets and sintered pellets produced therefrom including mixing a dopant with water and kaolin clay to form substantially round and spherical green pellets and sintering the pellets to form a proppant. The dopant is selected from the group consisting of potassium carbonate, potassium sulfate, potassium chloride, mica, kalsilite, and combinations thereof.2009-05-07
20090118146IMPREGNATING OIL COMPOSITION FOR SINTERED BEARING, BEARING APPARATUS AND SLIDING MEMBER - The novel impregnating oil composition for a sintered bearing is disclosed. The composition comprises a base oil, at least one compound represented by a formula (1).2009-05-07
20090118147LOW VOLATILE ORGANIC CONTENT LUBRICANT - A water-based lubricant composition, comprising: water, molybdenum disulfide, polytetrafluoroethylene, and a polymeric binder, wherein the binder is an acrylic resin or a polyurethane resin.2009-05-07
20090118148LOW-FRICTION SLIDING MECHANISM2009-05-07
20090118149Oil Type Lubricant for Forging, Forging Method and Spray Apparatus - An oil type lubricant for forging, which is featured in that the flash point thereof is confined to the range of 70-170° C., the kinematic viscosity thereof at 40° C. is confined to the range of 4-40 mm2009-05-07
20090118150Process for Preparing Polymers and Compositions Thereof - The present invention provides a process for preparing a polymer, employing the steps of: (1) contacting a free radical initiator; a chain transfer agent containing a thiocarbonyl thio group and a free radical leaving group; and a radically polymerisable monomer, to form a polymer chain; and (2) contacting the polymer chain of step (1) with at least one of a polyvalent coupling agent, a polymerisation inhibitor, a grafting acylating agent, an amine and an oil of lubricating viscosity. The invention further provides compositions and uses for the polymer.2009-05-07
20090118151Metal-Processing Oil Composition and Metal-Processing Method - The present invention provides a water-soluble metal-processing oil composition which is excellent in putrefaction resistant properties and sparingly has any bad influence upon global environment and human body and a method for processing metals which makes use of the metal-processing oil composition.2009-05-07
20090118152CLEANSING COMPOSITIONS INCLUDING MODIFIED SORBITAN SILOXANES AND USE THEREOF - The present disclosure generally relates to personal care cleansing compositions and wipes. More particularly, the disclosure relates to single phase compositions and wipes for cleansing the skin and/or hair of a user, while additionally, imparting a perceivable aesthetic feel to the skin of a user. To achieve both cleansing and the perceivable aesthetic feel, a modified sorbitan siloxane is incorporated into the compositions and wipes.2009-05-07
20090118153METALS COMPATIBLE POST-ETCH PHOTORESIST REMOVER AND/OR SACRIFICIAL ANTIREFLECTIVE COATING ETCHANT - A liquid removal composition and process for removing photoresist and/or sacrificial anti-reflective coating (SARC) material from a microelectronic device having same thereon. The liquid removal composition includes at least one organic quaternary base and at least one surface interaction enhancing additive. The composition achieves at least partial removal of photoresist and/or SARC material in the manufacture of integrated circuitry with minimal etching of metal species on the microelectronic device, such as copper and cobalt, and without damage to low-k dielectric materials employed in the microelectronic device architecture.2009-05-07
20090118154Acidic Cleaning Compositions - A cleaning composition with a limited number of natural ingredients contains alkyl polyglucoside, a 2-hydroxylcarboxylic acid, and a fragrance containing lemon oil or d-limonene. The cleaning composition optionally has a small amount of dye, colorant, and preservative. The cleaning composition can be used to clean hard surfaces and cleans as well or better than commercial compositions containing synthetically derived cleaning agents.2009-05-07
20090118155Liquid Whitening Maintenance Composition - The present invention provides a liquid laundry liquid detergent formulation comprising a dye that reduces precipitation of the dye.2009-05-07
20090118156COLOR CHANGING BAR SOAP - A color changing bar soap includes a small toy or figurine located inside a color changing layer such as a bicarbonate shell. The bicarbonate shell is housed within a body of soap. The bicarbonate surrounds and encapsulates the small toy. The soap fully surrounds and encapsulates the bicarbonate layer. The body of soap can be shaped like an egg or other various shapes to be determined, depending on the type of toy to be used with the soaps. In one embodiment, the egg-shaped soap is packaged onto a “nest-like” bail of hay or straw. This is placed inside a wooden or plastic crate for storage and use in a display.2009-05-07
20090118157Processes For Production Of Wine Lactone And Its Intermediates And Application Of The Lactone - The present invention provides a method for producing wine lactone, a method for producing intermediates that are usable in production of wine lactone, and techniques for the application of wine lactone. The method for producing the wine lactone (Compound (6)) of the present invention comprises the following steps (A) to (E):2009-05-07
20090118158COMPOSITIONS FOR ENHANCED EPITHELIAL PERMEATION OF PEPTIDE YY FOR TREATING OBESITY - Pharmaceutical compositions comprising PYY(3-36), a cyclodextrin, and a compound selected from phosphatidylcholine or diglyceride, wherein the PYY(3-36) is present in an amount effective to alleviate one or more symptom(s) of obesity in a subject, and the cyclodextrin and the compound selected from phosphatidylcholine or diglyceride are present in an amount sufficient to enhance epithelial permeation.2009-05-07
20090118159HETEROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES - Compounds of formula (I)2009-05-07
20090118160HETEROCYCLIC COMPOUNDS AND METHODS OF USE - Compounds of the formula2009-05-07
20090118161TREATMENT OF MEDICAL CONDITION WITH A2 DOMAIN OF VON WILLEBRAND FACTOR - The present invention is directed to methods for the prevention, treatment and/or diagnosis of a medical condition, such as sepsis, systemic inflammatory reaction syndrome, and/or thrombosis, for example. In particular, the method employs part or all of the A2 domain of von Willebrand factor. In certain cases, a recombinant A2 domain is utilized for the treatment of sepsis, systemic inflammatory reaction syndrome, and/or thrombosis, for example.2009-05-07
20090118162INHIBITORS OF SERINE PROTEASE ACTIVITY AND THEIR USE IN METHODS AND COMPOSITIONS FOR TREATMENT OF GRAFT REJECTION AND PROMOTION OF GRAFT SURVIVAL - Embodiments of the present invention illustrate methods of treating and preventing transplantation and side effects associated with transplantation. In particular, the present invention relates to compositions and methods for inhibition of graft rejection and promotion of graft survival. Thus, the invention relates to modulation of cellular activities, including graft rejection, promotion of graft survival, graft versus host rejection and conditions commonly associated with graft rejection. More particularly, the present invention relates to the inhibitory compounds comprising naturally occurring and man-made inhibitors of serine protease and inducers of other alpha1-antitrypsin activities.2009-05-07
20090118163Factor H for the Treatment of Chronic Nephropathies and Production thereof - The invention is directed to novel uses of Factor H, in particular in antibody-independent chronic nephropathies, e.g. in tubulointerstitial fibrosis (TIF). The invention is further directed to novel large scale manufacturing processes for Factor H.2009-05-07
20090118164METHODS AND COMPOUNDS FOR THE TARGETED DELIVERY OF AGENTS TO BONE FOR INTERACTION THEREWITH - Bone targeted compounds and methods are provided. Compounds can include a Bone Targeting Portion (R2009-05-07
20090118165METHOD OF TREATING CHEMOTHERAPY-INDUCED THROMBOCYTOPENIA - A method of treating chemotherapy-induced thrombocytopenia includes administering to a subject undergoing chemotherapy a therapeutically effective amount of a Bax-inhibiting peptide.2009-05-07
20090118166Conditioned Decellularized Native Tissues for Tissue Restoration - The invention provides a composition conditioned for the remodeling, restoration, repair, or replacement of tissue within a host. The composition is conditioned by culturing cells on the matrix and/or by exposing the cultured cells or matrix to one or more stressors.2009-05-07
20090118167Selective Vpac2 Receptor Peptide Agonists - The invention provides VPAC2R peptide agonists coupled to at least one polyethylene glycol molecule or derivative thereof, resulting in a biologically active peptide with an extended half-life and a slower clearance when compared to that of unPEGylated peptide.2009-05-07
20090118168TOPICAL ADMINSTRATION OF ACYCLOVIR - The present invention provides a topical composition comprising (a) at least one delivery agent compound and (b) a acyclovir compound. Methods of treatment, and methods of preparing the topical composition are also provided.2009-05-07
20090118169NOVEL COMPOUNDS AND PHARMACEUTICAL USE THEREOF - A compound comprising the atom corresponding to N2009-05-07
20090118170BUCCAL, POLAR AND NON-POLAR SPRAY OR CAPSULE - Buccal aerosol sprays or capsule using polar and non-polar solvent have now been developed which provide biologically active compounds for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal polar compositions of the invention comprises formulation I: polar solvent 37-98.58%, active compound 0.005-55%, optionally containing flavoring agent 0.1-10%.2009-05-07
20090118171Use of enzymatic inhibitors of h-prune for the prevention and treatment of the metastases of tumours overexpressing h-prune - The invention relates to the use of enzymatic inhibitors of h-PRUNE and to screening method for the prevention and treatment of the metastases of tumours overexpressing h-PRUNE thereof and to the diagnostic kit for the prognosis of said metastases thereof.2009-05-07
20090118172Shortened glucagon-like peptide 1(sglp-1) preparation method and application - This invention relates to similar compound of glucagon-like peptide 1(glucagon-like peptide-1, GLP-1) secreted by insulinotropic hormone, i.e. shortened glucagon-like peptide 1(sGLP-1) consisting of 26 aminoacids. Its sequence is as follows:2009-05-07
20090118173TREATMENT AND PREVENTION OF INFLAMMATORY BOWEL DISEASES - The present invention relates to the use of heat shock proteins, or fragments thereof, for the treatment and/or prevention of Inflammatory Bowel Diseases. Preferably bacterial and/or mammalian heat shock proteins belonging to the HSP70 families are used.2009-05-07
20090118174Novel peptides and methods for the treatment of inflammatory disorders - Novel peptides, nucleic acids encoding them, and derivatives of the peptides are described. The peptides and nucleic acids are of use in modulating β2 integrin function and in treating β2 integrin-mediated inflammatory disorders.2009-05-07
20090118175Compositions and Methods for Detection, Prognosis and Treatment of Breast Cancer - The present invention relates to methods of detection, prognosis and treatment of breast cancer using a plurality genes or gene products present in normal and neoplastic cells, tissues and bodily fluids. Gene products relate to compositions comprising the nucleic acids, polypeptides, antibodies, post translational modifications (PTMs), variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. Additional uses include identifying, monitoring, staging, imaging and treating cancer and non-cancerous disease states in breast as well as determining the effectiveness of therapies alone or in combination for an individual. Therapies include gene therapy, therapeutic molecules including but not limited to antibodies, small molecules and antisense molecules.2009-05-07
20090118176Stem Cell Factor-Like Protein Scfa1 and Uses Thereof - Methods for stimulating epithelial cell proliferation and for treating oral and gastrointestinal disorders are described. The methods use compositions comprising stem cell factor-like protein A1 (SCFA1) polypeptides and polynucleotides.2009-05-07
20090118177USE OF NERVE GROWTH FACTOR IN EYE-DROPS FOR THERAPY OF PATHOLOGIES OF THE CENTRAL NERVOUS SYSTEM, SUCH AS ALZHEIMER'S AND PARKINSON'S DISEASE - Nerve growth factor (NGF), in the form of a preparation for administration on the ocular surface, is proposed for use in the therapy and/or prophylaxis of pathologies affecting brain tissues and encephalic structures, with particular reference to pathologies affecting the hippocampus, cerebral cortex, basal forebrain, medial septum, Broca's diagonal band, Meynert's basal nucleus, substantia nigra pars compacta, striatum and cerebellum. Applied in the form of an external ophthalmic preparation, for example, as eye-drops or ointment, the NGF is able to pass from the ocular surface to the brain tissues, and has been found to exert a therapeutic action on pathologies of the central nervous system, and particularly on Alzheimer's Disease and Parkinson's Disease.2009-05-07
20090118178Y4 SELECTIVE RECEPTOR AGONISTS FOR THERAPEUTIC INTERVENTIONS - Y4 receptor agonist peptide selected from the group consisting of: [Ala30]PP2009-05-07
20090118179Therapeutic Agent for Dentin-Pulp Complex Regeneration - The present invention provides a therapeutic agent for regenerating a dentin-pulp complex, containing a basic fibroblast growth factor and/or a homolog thereof as an active ingredient. The present invention also provides a pulp-capping agent containing a basic fibroblast growth factor and/or a homolog thereof as an active ingredient.2009-05-07
20090118180USE OF FUSION PROTEINS FOR THE PREVENTION OR THE TREATMENT OF PATHOLOGIES RESULTING FROM ISCHEMIA - The present invention relates to the use of a fusion protein including a peptide sequence having membrane transducing properties, and a peptide sequence having cell survival properties, or a nucleic acid coding for the fusion protein, for the manufacture of a medicament intended for the prevention or the treatment of pathologies resulting from ischemia.2009-05-07
20090118181Compositions and methods for producing bioactive fusion proteins - Disclosed is a composition of matter involving a recombinant fusion protein comprising a a pharmacologically active protein partner, and a small pharmacologically inactive protein domain partner of human origin, such as but not limited to, a 102009-05-07
20090118182Fibroblast Growth Factor-Like Polypeptides - The present invention provides novel Fibroblast Growth Factor-like (FGF-like) polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, antibodies and methods for producing FGF-like polypeptides. Also provided for are methods for the diagnosis and treatment of diseases associated with FGF-like polypeptides.2009-05-07
20090118183ERYTHROPOIETIN RECEPTOR PEPTIDE FORMULATIONS AND USES - The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, and dosages are also provided.2009-05-07
20090118184RECOMBINANT FACTOR VIII HAVING INCREASED STABILITY - The present invention relates to a recombinant factor VIII that includes one or more mutations that result in enhanced stability of both factor VIII and factor VIIIa. Methods of making and using the recombinant factor VIII, and pharmaceutical compositions containing the same are also disclosed. The present invention further relates to an isolated nucleic acid molecule that encodes the recombinant factor VIII, as well as DNA expression systems and host cells containing the isolated nucleic acid molecule.2009-05-07
20090118185RECOMBINANT FACTOR VIII HAVING REDUCED INACTIVATION BY ACTIVATED PROTEIN C - The present invention relates to a recombinant factor VIII that is characterized by one or more mutations within a region surrounding an activated protein C cleavage site, which one or more mutations result in a reduced rate of inactivation by activated protein C. Isolated nucleic acid molecules, recombinant expression vectors, and host cells suitable for expression of the recombinant factor VIII are also disclosed. The recombinant factor VIII can be used for the treatment of clotting disorders, such as hemophilia A.2009-05-07
20090118186Use of TRAIL Polypeptides to Treat Cancer - A novel cytokine designated TRAIL induces apoptosis of certain target cells, including cancer cells and virally infected cells. Isolated DNA sequences encoding TRAIL are disclosed, along with expression vectors and transformed host cells useful in producing TRAIL polypeptides. Antibodies that specifically bind TRAIL are provided as well.2009-05-07
20090118187Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto - The present application is directed to the discovery that preparations of hedgehog polypeptides can be used to control the formation and/or maintenance of epithelial tissue.2009-05-07
20090118188Activin-actriia antagonists and uses for decreasing or inhibiting FSH secretion - In certain aspects, the present invention provides compositions and methods for decreasing FSH levels in a patient. The patient may, for example, be diagnosed with an FSH-related disorder or desire to delay or inhibit germ cell maturation.2009-05-07
20090118189Novel angiogenic composition-based methods - The invention relates to a composition for promoting angiogenesis, for controlling DNA synthesis of a cell, and for controlling chemotactic motility of a cell. The invention also relates to a method for treating ischemia diseases.2009-05-07
20090118190MUTEINS OF FIBROBLAST GROWTH FACTOR 21 - The present invention relates to novel muteins of human fibroblast growth factor 21 with improved pharmaceutical properties. Both protein and the respective encoding nucleic acid species are disclosed. The invention also embodies vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Also disclosed are methods for treating type 2 diabetes, obesity, metabolic syndrome, and in reducing the mortality and morbidity of critically ill patients.2009-05-07
20090118191Anti-Antiogenic Fragments of Pigment Epithelium-Derived Factor (PEDF) - The present invention provides anti-angiogenic derived from pigment epithelium-derived factor (PEDF) pharmaceutical compositions comprising the peptides, and methods of preventing angiogenesis. Such methods are useful in treating angiogenesis-associated disorders and diseases.2009-05-07
20090118192METHODS USEFUL IN THE TREATMENT OF BONE RESORPTION DISEASES - The invention relates to a combined pharmaceutical preparation comprising parathyroid hormone and a bone resorption inhibitor, said preparation being adapted for (a) the administration of parathyroid hormone during a period of approximately 6 to 24 months; (b) after the administration of parathyroid hormone has been terminated, the administration of a bone resorption inhibitor during a period of approximately 12 to 36 months.2009-05-07
20090118193PEGYLATED MUTATED CLOSTRIDIUM BOTULINUM TOXIN - The invention relates to a modified botulinum toxin comprising a natural heavy chain and a modified light chain, characterized in that the modification of the light chain resides in that it comprises (i) an extension of the chain on its N-terminus which has the structure —(C)2009-05-07
20090118194Measurement of melanocortin peptides and uses thereof - The present invention relates to melanocortin peptides and to methods that utilise melanocortin peptides, their measurement, their receptors and biological response systems for the risk assessment and diagnosis of disease. The biological response systems are also utilised to screen for compounds that act as agonists or antagonists of melanocortin receptors.2009-05-07
20090118195Molecules Which Promote Hematopoiesis - The invention relates to supravalent peptide compounds depicting an enhanced efficacy. Supravalent compounds comprise several at least bivalent peptide units that bind to a receptor target and are connected to a large polymeric carrier unit.2009-05-07
20090118196LKKTET And/Or LKKTNT Peptide Compositions Which Are Lyophilized Or In A Form Capable of Being Lyophilized - A composition including a peptide agent including amino acid sequence LKKTET or LKKTNT, a conservative variant thereof, or a stimulating agent that stimulates production of an LKKTET or LKKTNT peptide, or a conservative variant thereof, the composition including at least one amino acid stabilizing agent or lyophilization bulking agent, the composition being in lyophilized form, or in a form capable of being lyophilized.2009-05-07
20090118197Immune-Modulating Peptide - Disclosed are peptides having SEQ ID NOs: 1 to 24 that induce superoxide generation by human monocytes or neutrophils; that induce an intracellular calcium increase by human peripheral blood monocytes or neutrophils; binds to formyl peptide receptor or formyl peptide receptor-like 1; that induce chemotactic migration of human monocytes or neutrophils in vitro; that induce degranulation in formyl peptide receptor expressing cells or formyl peptide receptor-like 1 expressing cells; that stimulate extracellular signal regulated protein kinase phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1; or that stimulate Akt phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1.2009-05-07
20090118198NOVEL PEPTIDE DERIVATIVES USEFUL AS ANTIMICROBIAL AGENTS FOR TREATING WOUNDS - The invention relates to a compound having the general formula (I) R2009-05-07
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