18th week of 2021 patent applcation highlights part 13 |
Patent application number | Title | Published |
20210128744 | THIENOAZEPINE IMMUNOCONJUGATES, AND USES THEREOF - The invention provides immunoconjugates of Formula I comprising an antibody linked by conjugation to one or more thienoazepine derivatives. The invention also provides thienoazepine derivative intermediate compositions comprising a reactive functional group. Such intermediate compositions are suitable substrates for formation of the immunoconjugates through a linker or linking moiety. The invention further provides methods of treating cancer with the immunoconjugates. | 2021-05-06 |
20210128745 | RAPID FORMATION OF SUPRAMOLECULAR HYDROGELS BY SHORT PEPTIDE AND BIOACTIVE SMALL MOLECULES - Disclosed are a peptide capable of induced self-assembly by a bioactive molecule comprising a (i) hydrogelation-promoting amino acid sequence and (ii) an oligomerization sequence; compositions containing the peptide and, optionally, bioactive molecule; hydrogels formed thereby; and various methods of using the same | 2021-05-06 |
20210128746 | DNA-TEMPLATED MICELLE AND USES THEREOF - The present invention discloses a multifunctional DNA-templated micelle system that has a payload carrier of at least a DNA bridge and a functionalized polyethylene glycol (PEG) segment. The micelle can be used to deliver molecules, such as drugs and polynucleotides, to targeted cells for pharmaceutical uses. The PEG segment provides a functional group, such as amine, for ligand conjugation. The DNA-templated micelle of the present invention is highly controllable in size, loading efficiency and tissue targeting, and can carry multiple payloads for targeted combination strategies in cancer therapy, such as gene delivery, gene therapy, and immunotherapy. | 2021-05-06 |
20210128747 | GUANYLUREA FUNCTIONALIZED PEPTIDES AND PROTEINS FOR THERAPEUTICS - A cell-penetrating peptide (CPP) comprising comprises a plurality of mono(amino acid)s, oligo(amino acid)s, or poly(amino acid)s where a plurality of the amino acids comprise a positively charged guanylurea unit with a small molecule fragment and each of the mono(amino acid)s, oligo(amino acid)s, or poly(amino acid)s comprising a drug attached through a linker. The CPP can be used for treating cancers. | 2021-05-06 |
20210128748 | THREE-DIMENSIONAL SELF-ASSEMBLED NUCLEIC ACID NANOPARTICLES AND USE THEREOF - The present invention relates to three-dimensional self-assembled nucleic acid nanoparticles, a drug delivery system comprising the same, and a pharmaceutical composition for the prevention or treatment of acute kidney injury, which comprises the same. The three-dimensional self-assembled nucleic acid nanoparticles of the present invention, which have a tetrahedral structure, exhibit an excellent renal-targeting ability, and thus the nanoparticles conjugated with the pharmaceutically active ingredient for p53 exhibit excellent p53 and caspase 3 expression reductions in vitro and in vivo, and can thereby be applied to the prevention or treatment of acute kidney injury. | 2021-05-06 |
20210128749 | ADENO-ASSOCIATED VIRUS VECTOR DELIVERY OF MUSCLE SPECIFIC MICRO-DYSTROPHIN TO TREAT MUSCULAR DYSTROPHY - The invention provides gene therapy vectors, such as adeno-associated vims (AAV) vectors, expressing a miniaturized human micro-dystrophin gene and method of using these vectors to express micro-dystrophin in skeletal muscle including diaphragm and cardiac muscle and to protect muscle fibers from injury, increase muscle strength and reduce and/or prevent fibrosis in subjects suffering from muscular dystrophy. | 2021-05-06 |
20210128750 | MODULATION OF NEURAL PATHWAYS - Provided herein are compositions and methods for the design of synthetic regulatory sequences and for subsequent modulation of neural pathways. | 2021-05-06 |
20210128751 | RECOMBINANT PROMOTERS AND VECTORS FOR PROTEIN EXPRESSION IN LIVER AND USE THEREOF - Disclosed herein are recombinant viral vectors comprising a liver specific promotor in operable combination with a heterologous nucleic acid sequence encoding a protein, such as a clotting factor. Methods of treating a subject with a clotting disorder, such as hemophilia A or hemophilia B, are also provided. | 2021-05-06 |
20210128752 | METHOD FOR CULTURING 3-DIMENSIONAL LUNG CANCER ORGANOID AND METHOD FOR PREPARING PATIENT-DERIVED XENOGRAFT ANIMAL MODEL USING SAME - The present invention relates to a method for culturing a 3-dimensional lung cancer organoid and a method for preparing a patient-derived xenograft animal model using the same. More specifically, the present invention relates to a method for culturing a 3-dimensional lung cancer organoid, a lung cancer organoid prepared by the method, a medium composition for culturing the lung cancer organoid, a method for preparing a xenograft animal model using the lung cancer organoid, a patient-derived lung cancer organoid xenograft animal model prepared by the method, and a method for analyzing therapeutic efficacy of an anticancer agent and a method for screening an anticancer agent, using the animal model. | 2021-05-06 |
20210128753 | ACTIVITY-BASED PROBE COMPOUNDS, COMPOSITIONS, AND METHODS OF USE - Activity-based probe compounds for use in labeling a cysteine protease are provided. The compounds are targeted to the protease through a specific targeting element. The compounds additionally include a detectable element, such as a fluorescent label, a radiolabel, or a chelator. In some cases, the compounds additionally include a quenching element that is released upon reaction with the protease. Also provided are compositions comprising the compounds and methods for using the compounds, for example in labeling a protease in an animal and in visualizing a tumor in an animal. | 2021-05-06 |
20210128754 | COMPOSITIONS FOR USE IN LYSIS OF SELECTIVE CANCER CELLS - The present invention relates to a method of necrosing, causing membranolysis, or causing poration of selective cancer cells. In some aspects, the method includes administering a peptide including PPLSQETFSDLWKLL-KKWKMRRN QFW VKV QRG or ETFSDLWKLL-KKWKMRRNQFWVKVQRG to a selective cancer cell to cause necrosis, membranolysis, or poration of said selective cancer cell. | 2021-05-06 |
20210128755 | TARGETING LIGANDS FOR TAU PATHOLOGY - Methods and compositions for detecting tau pathology are described. The compositions for detecting tau pathology comprise a targeting ligand that specifically binds to a cell surface marker of tau pathology, wherein the targeting ligand is linked to a liposome that includes an imaging agent. The compositions can be used in a method for imaging tau pathology in a subject that comprises administering to the subject an effective amount of the composition to a subject and imaging at least a portion of the subject to determine if that portion of the subject exhibits tau pathology. The compositions can also be used to detect tau pathology in biological samples obtained from a subject. | 2021-05-06 |
20210128756 | RADIOLIGANDS FOR MYELIN - A radioligand for labeling myelin includes a fluorescent trans-stilbene derivative. | 2021-05-06 |
20210128757 | TRIFUNCTIONAL CONSTRUCTS WITH TUNABLEPHARMACOKINETICS USEFUL IN IMAGING AND ANTI-TUMOR THERAPIES - The present technology provides compounds, as well as compositions including such compounds, useful for imaging and/or treatment of a glioma, a breast cancer, an adrenal cortical cancer, a cervical carcinoma, a vulvar carcinoma, an endometrial carcinoma, a primary ovarian carcinoma, a metastatic ovarian carcinoma, a non-small cell lung cancer, a small cell lung cancer, a bladder cancer, a colon cancer, a primary, gastric adenocarcinoma, a primary colorectal adenocarcinoma, a renal cell carcinoma, and/or a prostate cancer. The compounds are represented by the following formula: (I) or a pharmaceutically acceptable salt thereof. | 2021-05-06 |
20210128758 | Composition Containing a Somatostatin Analogue for Radiopharmaceutical Use - The present invention relates to a somatostatin analogue composition for radiopharmaceutical use, in particular for diagnostic or therapeutic use. More specifically the somatostatin analogue is a receptor-selective somatostatin peptide antagonist. | 2021-05-06 |
20210128759 | DECONTAMINATION DEVICE, ISOLATOR SYSTEM, AND OPERATING METHOD - A decontamination device ( | 2021-05-06 |
20210128760 | STERILIZING APPARATUS, IN PARTICULAR FOR STERILIZING POST-CONSUMER ABSORBENT SANITARY PRODUCTS - An apparatus for sterilizing post-consumer absorbent sanitary products, comprising: a container rotatable about a longitudinal axis, having a closed first end and a second end provided with an opening for loading/unloading, closed by a removable door, wherein the container has a hollow wall including an inner wall, an outer wall, and a hollow space, which extends from said first end to said second end, a rotary joint located at said first end of the container and having a steam inlet chamber and a condensate discharge chamber, at least one hollow helical blade, which extends between said first end and said second end of the container and protrudes inwardly from said inner wall of the container. | 2021-05-06 |
20210128761 | STERILIZATION MANAGEMENT DEVICE AND METHODS FOR OPERATING SAME - A method for controlling an environment within a sterilizer device is disclosed. The method includes equipping an interior space of the sterilizer device with an auxiliary device having a temperature sensor, a humidity sensor, a heating element, monitoring temperature within the sterilizer device, receiving, by the sterilization device, information associated with an initiation of a sterilization cycle of the sterilizer device; monitor duration of the sterilization cycle, receiving, by the sterilization device, information associated with an end of a sterilization cycle of the sterilizer device, determining whether a current humidity measurement is above a predefined threshold, and controlling the heating element to an ON operating state when the current humidity measurement is above the predefined threshold. | 2021-05-06 |
20210128762 | SYSTEMS, METHODS, AND APPARATUS FOR DEVICE SANITIZATION - A sanitization device comprises primary emitters configured to emit sanitizing electro-optical (EO) radiation into an interior compartment. A support member is configured to hold and/or secure a target object within the interior compartment of a sanitization device. An end portion of the support member may extend into a secondary compartment comprising a secondary emitter configured to produce external stimulus adapted to excite and recover primary emitters from dormancy. The support member is configured to transmit EO radiation produced by the secondary emitter into the interior compartment to thereby prevent and/or recover from dormancy conditions of the primary emitters. Detection circuitry can detect activation failures of the primary emitters. Thermal management circuitry can limit certain critical failures of a sanitization device that result from activation failures of primary emitters. | 2021-05-06 |
20210128763 | PERFORMANCE MONITORING SYSTEM AND METHOD FOR AN ADVANCED OXIDATION PROCESS (AOP) WATER SANITIZER - A system for monitoring performance of a water sanitation device includes a housing having a water flow path, a power source, an ozone generating element configured to provide ozone to the water flow path, and an ultraviolet (UV) light generating element configured to expose the water in the flow path to UV light, a first monitoring circuit configured to monitor at least one operational aspect of the ultraviolet (UV) light generating element, a second monitoring circuit configured to monitor at least one operational aspect of the ozone generating element, a control circuit configured to receive an output of the first monitoring circuit and an output of the second monitoring circuit, and a display element configured to provide an indication of a status of at least one of the power source, the ultraviolet (UV) light generating element and the ozone generating element. | 2021-05-06 |
20210128764 | DEPLOYABLE ULTRAVIOLET LIGHT SANITIZING SYSTEMS AND METHODS - An ultraviolet (UV) light sanitizing system and method are configured to sanitize at least one surface within an enclosed space. The UV light sanitizing system includes a UV light assembly that is selectively moveable between a stowed position and a deployed position. The UV light assembly is stowed within a stowage chamber connected to the enclosed space in the stowed position. The UV light assembly deploys out of the stowage chamber and into the enclosed space in the deployed position. | 2021-05-06 |
20210128765 | MAGNETIC LATCH CONNECTOR ASSEMBLY - A connector is configured to electrically connect a plasma emitter array with an identification chip to a power supply controller, and to further mechanically support the emitter device supporting the array during use. Cooperating components of the connector and emitter device form a magnetic latch assembly: the connector includes one or more magnets flush with a top receiving surface of the connector, and one or more alignment pegs extending outward from the receiving surface; the emitter device includes a steel plate attached to a substrate, and one or more holes disposed through the plate and the substrate. The holes align with the alignment pegs and the magnets attract the plate and secure the emitter device against the top receiving surface. Electrical contacts of the connector establish electrical communication with the identification chip, providing power to the emitter device and enabling the controller to read data stored in the identification chip. | 2021-05-06 |
20210128766 | FOGGING SYSTEM PROVIDING ATOMIZED SOLUTION AND ULTRAVIOLET LIGHT TO TREATMENT AREA - A system for disinfecting an enclosed area may include a humidity sensor, and a fogging device including a portable housing, an atomizing disinfectant generator carried by the portable housing, at least one output circuit carried by the portable housing, and a processor carried by the portable housing. The processor may be configured to determine a humidity level within the enclosed area based upon the humidity sensor, operate a humidity control device via the at least one output circuit responsive to the determined humidity control level being outside of a starting humidity range, cease operating the humidity control device responsive to the humidity level being within the starting humidity range based upon the humidity sensor, and initiate a treatment cycle during which the atomizing disinfectant generator dispenses atomized disinfectant fluid into the enclosed area. | 2021-05-06 |
20210128767 | Method and Apparatus for Providing Polyiodide Resin Powder-Enhanced Personal Protective Equipment (PPE) - Disclosed is a method and apparatus for providing polyiodide resin-enhanced personal protective equipment (PPE) including but not limited to face masks, gloves, gowns and respirators. The disclosed method comprises the application of a polyiodinated ink polymer in or on one or more targeted surfaces of PPE to create a molecular sub-microscopic protective barrier between the equipment and the user. The disclosed system provides a PPE device capable of direct contact kill of organisms. In addition, the system provides for a sustained kill of organisms for up to 96 hours. The resultant PPE device is broadly effective against viral, bacterial, fungicidal and other microbial agents. | 2021-05-06 |
20210128768 | PACKAGING FOR USE IN A DECONTAMINATION SYSTEM - An apparatus for use in a method of decontaminating a device including a tray. A membrane permeable by a decontaminating fluid is positioned over the top of the tray to form an enclosed space. A lid is secured to the tray and the membrane is positioned between the tray and the lid. A hub assembly is positioned within the tray. | 2021-05-06 |
20210128769 | AUTOMATIC SOURCE-SEEKING INDOOR POLLUTION PURIFYING AND REMOVING DEVICE AND METHOD - The present invention discloses an automatic source-seeking indoor pollution purifying and removing device and method for airborne pollutants. The device comprises pollutant concentration sensors, a control unit, a position sensor, a power plant, a moving mechanism, a telescopic device, a pollutant collection hood, and a filtering and purifying device. The control unit can identify the actual release positions and hourly release rates of relevant pollutants according to the concentration data monitored by the pollutant concentration sensors, and can control the pollutant collection hood in the device to move to a designated position in a space, so as to realize the collection and removal of pollutants at the release position of the pollutants. | 2021-05-06 |
20210128770 | AIR FRESHENING DEVICE - An air freshening device is provided. The device includes a water-based fragrance emitter including water, a water absorbing polymer and a fragrance composition. The fragrance composition includes from about 3% to about 70% by weight of at least one fragrance ingredient exhibiting a standard equilibrium headspace concentration (HS | 2021-05-06 |
20210128771 | Rotational Aroma Diffuser Structure - An aroma diffuser structure includes a base, a holding member, a frame, an adjusting member, and an aroma diffuser. The holding member is mounted on the base and has a screw hole. The frame is mounted on the holding member and has an upper portion provided with a first magnetic member. The adjusting member has an external threaded section extending through the frame and screwed through the screw hole of the holding member. The aroma diffuser has a plurality of air vents. The aroma diffuser is rotatable on the adjusting member and has a top provided with a rotation shaft which is provided with a second magnetic member magnetically attracted with the first magnetic member. | 2021-05-06 |
20210128772 | NEBULIZER DIFFUSER - A nebulizer diffuser comprises a base, a nebulizer module, a power supply unit, at least one fluid container module, and a cover. The base comprises a conducting chamber comprising a first through hole, wherein the conducting chamber is for holding a first fluid; an accommodation space, wherein the conducting chamber is located above the accommodation space. The nebulizer module comprises an oscillator and a controller which manages the operation of the oscillator, wherein the oscillator is attached to the first through hole and the controller is disposed in the accommodation space. The power supply unit is disposed in the accommodation space and electrically connected to the nebulizer module. The at least one fluid container module comprises a fluid tank separably located on the conducting chamber and the fluid tank is for holding a second fluid. The cover separably covers on the fluid tank and an air chamber is formed thereinside. | 2021-05-06 |
20210128773 | AROMA CARTRIDGE, AROMA DISPLAY AND METHOD OF LOADING AND UNLOADING AROMA DISPLAY WITH AROMA CARTRIDGE - An aroma cartridge | 2021-05-06 |
20210128774 | Antiviral Air-Filtering Lighting Device Using Visible Light - An antiviral air-filtering lighting device includes an air-permeable lampshade, a visible light source, a driver, and an air circulation mechanism. The lampshade diffuses a visible light emitted from the visible light source and includes an air inlet port. The lampshade is coated with a visible-light activatable antiviral photocatalytic coating. The visible light source is disposed inside the lampshade to shine its light through the lampshade to activate the visible-light activatable antiviral photocatalytic coating on the lampshade. The air circulation mechanism sucks an ambient air from outside the lighting device, and forces the air through the lampshade. The lampshade traps airborne microbials on the surface having the visible-light activatable antiviral photocatalytic coating. A light emitted by the first visible light source activates a photocatalyst material in the visible-light activatable antiviral photocatalytic coating, and the airborne microbials trapped by the air filter are killed or deactivated by the activated photocatalyst material. | 2021-05-06 |
20210128775 | DISCHARGE DEVICE AND ELECTRIC MACHINE - Provided is a discharge device that can improve the efficiency of generating reactive species. A discharging unit that discharges in response to an application of a voltage protrudes from a housing. The discharging unit is disposed in a duct through which gas flows. An upstream support is disposed upstream of the discharging unit in a direction of gas flow without overlapping the discharging unit. The upstream support protrudes further from the housing than the discharging unit. The upstream support includes a root portion joined to the housing. The root portion includes a widened portion that is disposed in the duct and that protrudes toward the discharging unit when viewed in the direction of gas flow. | 2021-05-06 |
20210128776 | NEGATIVE ION GENERATOR, WEARABLE AIR PURIFIER HAVING THE AFOREMENTIONED NEGATIVE ION GENERATOR, AND METHOD OF MANUFACTURING THE AFOREMENTIONED NEGATIVE ION GENERATOR - A negative ion generator includes a fiber bundle, a boost circuit board, a sleeve component and an electrically conductive adhesive. The fiber bundle includes a combining portion. The boost circuit board is connected to the fiber bundle and includes an electrically conductive terminal. An output end of the electrically conductive terminal is inserted into the combining portion of the fiber bundle. The boost circuit board provides a high-voltage current to the fiber bundle to enable the fiber bundle to emit negative ions by corona discharging. An accommodating space is enclosed by the sleeve component. The combining portion of the fiber bundle is installed inside the accommodating space. The electrically conductive adhesive is poured into the accommodating space and located between the combining portion of the fiber bundle and the output end of the electrically conductive terminal for adhering and electrically connecting the fiber bundle to the electrically conductive terminal. | 2021-05-06 |
20210128777 | ADDITIVE ABLE TO PROVIDE UNDERWATER ADHESION - Compositions and methods for sealing tissue of a patient in a wet environment are disclosed. | 2021-05-06 |
20210128778 | SOLVENT DEPOSITION SYSTEM AND METHODS - A hemostatic device comprising a biomaterial matrix and a polymeric material prepared by combining the polymeric material with a solvent, applying the combination to the biomaterial, removing the solvent, and retaining an effective layer of the polymeric material to the biomaterial to enhance the performance of the hemostatic device in the treatment of wounds. | 2021-05-06 |
20210128779 | WATER-CONTAINING HYDROGELS FOR DRESSING WOUNDS - The invention relates to water-containing hydrogels for dressing wounds, comprising a polyurethane-polyurea copolymer having a polyvalent alcohol, except propylene glycol. | 2021-05-06 |
20210128780 | OSTEOSTIMULATIVE, BIOACTIVE AND FLOWABLE BONE VOID FILLER - An osteostimulative, bioactive and flowable bone void filler or bone cement. This bone void filler may be a settable, hardening material having sufficient compression strength for use in bone repair techniques. The cement may be a calcium phosphate cement having incorporated therein bioactive glass, and can be used as a bone graft substitute or bone void filler for any number of applications in spine surgery and orthopedic surgery, such as for example, subchondral bone repair. | 2021-05-06 |
20210128781 | GLASS STRUCTURE AND METHOD FOR PRODUCING THE SAME - A glass structure includes: a plurality of glass particles, each of the glass particles including SiO | 2021-05-06 |
20210128782 | ANTI-MICROBIAL IMPLANT COATING - A coating for an implant component, in particular a component of a spinal implant, is provided. The coating is a ceramic titanium nitride coating comprising an at % content of 5 to 30 At % of Ag in addition to an at % content of Ti and an at % content of N. | 2021-05-06 |
20210128783 | LAMINATED SKIN MIMETIC - The present disclosure features a skin mimetic, including a base layer including a hydrogel; and a top layer including a synthetic stratum corneum. The skin mimetic mimics a skin portion of a human subject, such as a facial skin portion. In an embodiment, the skin mimetic can serve as a mimic for a cheek skin portion, for example, for use in the testing of cosmetic products, therapeutic agents, moisturizers, shaving products, other skin care products, and the like. | 2021-05-06 |
20210128784 | Cancellous Bone Product Including Viable Osteogenic Cells - A bone implant comprising cancellous bone that is essentially free of blood cells, and which has been treated with at least one loosening agent, such as collagenase or a digestive enzyme, for a time and at a concentration to loosen the osteogenic cells in the cancellous bone matrix. The osteogenic cells in the matrix are viable cells. The treatment of the cancellous bone with at least one loosening agent enables the osteogenic cells to be more available for carrying out their osteogenic function and to provide for an increased rate of bone formation. Such implant also may include demineralized bone, such as demineralized cortical bone, which enhances the bone regenerative capacity of the cancellous bone. | 2021-05-06 |
20210128785 | BIOARTIFICIAL VASCULAR PANCREAS - The present invention provides compositions, systems and methods for treating diabetes in a subject. The composition of the present invention includes a decellularized vascular graft, a biocompatible hydrogel encasement with tunable rigidity, and a plurality of cells such as pancreatic islet cells. | 2021-05-06 |
20210128786 | AVIAN BASED LUNG ASSIST DEVICE - Compositions, materials, devices and methods are disclosed for the use of decellularized avian lung scaffolds for potential xenotransplantation and other uses including use as novel lung assist or bridge-to-transplant devices and as potential alternatives to current ECMO devices and technologies. Decellularization of an avian lung and recellularization with human lung cells is described. | 2021-05-06 |
20210128787 | SURGICAL IMPLANT MATERIAL FOR ASSISTED REPAIR OF MUSCLE MECHANICS AND METHOD OF PREPARING THE SAME - The present invention provides a surgical implant material for assisted repair of muscle mechanics and a method of preparing the same. The surgical implant material for assisted repair of muscle mechanics comprises a collagen compound within a net-like bacterial cellulose base material. A bacterial cellulose base material is placed into solution of collagen, treated via vortex shaking, dried at room temperature; and then immersed in an aqueous solution of an aldehyde compound under vacuum to react for 10 to 30 minutes, thereby producing the surgical implant material for assisted repair of muscle mechanics. The surgical implant material of the present invention can effectively improve the biocompability, and maintain the flexibility, smoothness and fitness of the base material to reduce the damage to surrounding tissues, thereby reducing the bleeding and inflammatory response. Meanwhile, the processing conditions of the preparation method is more reasonable and convenient to control, and more suitable for industrial scale-up. | 2021-05-06 |
20210128788 | ARTIFICIAL BLOOD VESSEL - The present invention provides an artificial blood vessel that can achieve a balance between cell penetration efficiency and crush resistance and can regenerate a blood vessel at very high efficiency. Provided is an artificial blood vessel having a tubular shape, including: a foam containing a bioabsorbable material; a reinforcement A containing a bioabsorbable material; and a reinforcement B including threads containing a bioabsorbable material, the foam being reinforced with the reinforcements A and B, wherein the reinforcement A is a non-woven fabric, a film, or a weft-knitted, warp-knitted, or woven fabric made of knitted or woven fibers, the reinforcement B includes monofilament threads each having a cross-sectional diameter of 0.1 mm or more and 1 mm or less, the reinforcement B includes a winding portion having a helical shape, a ring shape, or an X shape and a warp thread portion stretched in a direction parallel to a longitudinal direction of the artificial blood vessel, and the artificial blood vessel is a composite including the reinforcement A and reinforcement B inside the foam. | 2021-05-06 |
20210128789 | TEXTILE PRODUCTS HAVING A SEALANT OR COATING AND METHOD OF MANUFACTURE - A textile graft includes a tubular wall disposed between a first open end and an opposed second open end and having an inner surface and an opposed outer surface. The tubular wall includes a textile construction of one or more filaments or yarns, the textile construction by itself being permeable to liquid. A portion of the inner surface of the tubular wall includes a coating of a substantially water-soluble material thereon. The outer surface includes a coating of a substantially water-insoluble elastomeric sealant disposed thereon. The tubular wall having the coating of the substantially water-insoluble elastomeric sealant is, after curing thereof, substantially impermeable to liquid. | 2021-05-06 |
20210128790 | CLICK-CROSSLINKED HYDROGELS AND METHODS OF USE - The present disclosure provides click-crosslinked hydrogels and methods of use. | 2021-05-06 |
20210128791 | GALVANIC REDOX MATERIAL AND IMPLANTABLE DEVICE AND METHODS THEREOF - The application discloses an implantable device, comprising a galvanic redox system formed on a body substrate of the implantable device. The implantable device has a non-zero surface potential when it is deployed. The galvanic redox system comprises a first metal site and a second metal site, the first metal site comprising a first metal having a first metal electrode potential (FMEP) and the second metal site comprising a second metal having a second metal electrode potential (SMEP), which FMEP being lower than SMEP and SMEP being substantially different such that the implantable device is galvanized when it is deployed. Methods of making and using the implantabe device are also disclosed. | 2021-05-06 |
20210128792 | ELECTROSPUN MATRIX AND METHOD - The present disclosure relates a biocompatible biodegradable polymer matrix which serves as a template for the growth of differentiated skin tissue comprising a dermis and an epidermis, the combination of the matrix and the differentiated skin, the method of preparing the same and the tissue obtainable from said method. The disclosure also extends to use of the differentiated skin in treatment. Thus, there is provided a matrix of electrospun fibres for growing differentiated skin tissue prepared by electrospinning solution of a biocompatible biodegradable polymer, wherein the electrospun fibres are about 0.3 μm to about 5 μm in diameter for example 1 to 5 μm, such as 1, 1.5, 2, 2.5, 3, 3.5, 4, or 4.5 μm | 2021-05-06 |
20210128793 | BIODEGRADABLE METALLIC MICRO-STRUCTURES. - Bioresorbable medical devices, such as stents, scaffolds and other medical devices implantable in human and animal bodies, in which galvanic couples are formed. The devices include bioresorbable amalgamates, wires, laminates, layered structures or combinations thereof. Also, methods of manufacturing the devices, including laminating, folding, 110 braiding, weaving, crocheting or cold spraying of materials with different galvanic potentials Also, machining of amalgamated materials using electrical discharge machining. | 2021-05-06 |
20210128794 | METHOD COMPRISING CONTACTING TISSUE WITH A CROSS-LINKABLE POLYESTER PREPOLYMER - The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked to form the elastic biodegradable polymer. In preferred embodiments, the cross-linking is performed by functionalization of one or more OR groups on the pre-polymer backbone with vinyl, followed by photopolymerization to form the elastic biodegradable polymer composition or material. Preferably, acrylate is used to add one or more vinyls to the backbone of the pre-polymer to form an acrylated pre-polymer. In various embodiments, acrylated pre-polymers are co-polymerized with one or more acrylated co-polymers. | 2021-05-06 |
20210128795 | SPIRAL COATED STENT WITH CONTROLLABLE GRADIENT DEGRADATION, PREPARATION METHOD THEREOF AND APPLICATION THEREOF - Disclosed are a spiral coated stent with controllable gradient degradation, a preparation method thereof and an application thereof. The spiral coated stent with controllable gradient degradation is composed of a degradable medical polyurethane and a degradable magnesium alloy material, wherein the degradable medical polyurethane contains a following chemical structure: PCL-PEG-PCL, wherein a molecular weight of the PEG is 200 to 1,000 and the molecular weight of the PCL is 200 to 10,000, and the degradable magnesium alloy material is of a spiral stent structure; and physical properties of the spiral coated stent with controllable gradient degradation need to satisfy the following technical parameters that: a breaking strength needs to be no less than 1 N, a pressure resistance needs to be no less than 2 N, and a degradation characteristic of the magnesium alloy after surface treatment shows gradient degradation with different time. | 2021-05-06 |
20210128796 | COMPOSITE STENT HAVING MULTI-AXIAL FLEXIBILITY AND METHOD OF MANUFACTURE THEREOF - A bioabsorbable composite stent structure, comprising bioabsorbable polymeric ring structures which retain a molecular weight and mechanical strength of a starting substrate and one or more interconnecting struts which extend between and couple adjacent ring structures. The ring structures can have a formed first diameter and being radially compressible to a smaller second diameter and re-expandable to the first diameter. The ring structures can comprise a base polymeric layer. The interconnecting struts can be formed from a polymer blend or co-polymer of poly-L-lactide (PLLA) and an elastomeric polymer. The interconnecting struts each can have a width that is less than a circumference of one of the ring structures. The adjacent ring structures can be axially and rotationally movable relative to one another via the interconnecting struts. The interconnecting struts can also be bioabsorbable. | 2021-05-06 |
20210128797 | DRUG-LOADED IMPLANTED MEDICAL DEVICE AND PREPARATION METHOD THEREFOR - A drug-loaded implanted medical device and a preparation method therefor. The drug-loaded implanted medical device comprises a device body and grooves ( | 2021-05-06 |
20210128798 | HEMOSTATIC DEVICES AND METHODS OF USE - An anchorage device is provided that is configured to surround an implantable medical device. The anchorage device includes a substrate having a hemostatic agent and an active pharmaceutical ingredient selectively positioned on the substrate. Kits, systems and methods are disclosed. | 2021-05-06 |
20210128799 | NEGATIVE PRESSURE WOUND THERAPY DEVICE CONTROL IN PRESENCE OF FAULT CONDITION - Embodiments of negative pressure wound therapy systems and methods are disclosed. In one embodiment, an apparatus includes a wound dressing, negative pressure source, switch, interface element, and control circuitry. The negative pressure source, switch, and interface element can be disposed on or within the wound dressing. The control circuitry can be in a first or second mode. In the first mode, the control circuitry can cause supply of negative pressure in response to a first user input via the switch when the negative pressure source is not supplying negative pressure and prevent supply of negative pressure in response to the first user input while the negative pressure source is supplying negative pressure, and the control circuitry can change from the first mode to a second mode in response to a second user input via the interface element. In the second mode, the control circuitry can disable supply of negative pressure. | 2021-05-06 |
20210128800 | IRRIGATION SLEEVE FOR OPHTHALMIC PROCEDURES - Devices and methods are disclosed for improved irrigation sleeves for ophthalmic instruments to prevent or reduce the likelihood of the irrigation sleeve twisting and/or buckling upon inserting the irrigation sleeve into the eye. In some embodiments, an irrigation sleeve comprises a side opening for irrigation having an elongated shape, wherein the elongated shape is longer in a direction parallel to the longitudinal axis of the distal tube of the irrigation sleeve than in a direction around a circumference of the distal tube of the irrigation sleeve. In some embodiments, an irrigation sleeve comprises at least one rib on an internal surface of the distal end of the irrigation sleeve. In some embodiments, the irrigation sleeve has been subjected to one or more manufacturing steps adapted to stiffen the irrigation sleeve, such as being coated with a stiffening coating or being treated by being exposed to gamma irradiation. | 2021-05-06 |
20210128801 | SYRINGE PUMP - A syringe pump to deliver heparin to into the blood circuit of a hemodialysis system. The syringe pump is configured to receive a syringe having a plunger movable within a lumen of an elongate tubular member. The syringe pump may include a housing having a recess configured to receive at least a portion of the syringe, a drive mechanism for moving the plunger within the lumen, the drive mechanism comprising a motor and a lead screw; and a grabber mechanism. The grabber mechanism includes a control arm, back panel, and upper and lower control fingers, the control fingers each have first and second ends, and a curved portion therebetween having a width, an interior edge, and an exterior edge, wherein the first ends of the upper and lower control fingers are coupled to the control arm via first and second spring hinges. | 2021-05-06 |
20210128802 | LEAK-RESISTANT BANDAGE SYSTEMS AND METHODS WITH HYDROPHILIC FOAM WOUND INSERT FOR FLUID-INSTILLATION AND/OR NEGATIVE-PRESSURE WOUND THERAPIES - Wound treatment systems and methods (e.g., having hydrophilic wound inserts), such as for negative-pressure and/or fluid-installation wound therapies. Some embodiments include a check-valve assembly between a wound dressing and a vacuum source. | 2021-05-06 |
20210128803 | ASSEMBLY COMPRISING A SUCTION DEVICE SUITABLE FOR BEING PLACED ON A WOUND AND/OR AN INCISION - An assembly including a suctioning device suitable for being placed on an incision and/or a wound of a patient to disinfect and/or dry the incision or wound, the device including a drape. The drape includes an outer layer with an upper face and a lower face, the upper face being impermeable, an inner layer, made of non-woven sterile material, including an upper face and a lower face, the lower face to come into contact with the wound and/or the incision. The drape is wound around a limb or around the body of the patient. The assembly also includes a suctioning zone having cavities, a discharge tube connected to the suctioning zone, and a suctioning member is a system for recovering portable or mobile autologous blood. | 2021-05-06 |
20210128804 | DRESSING DESIGN INCORPORATING FORMED 3D TEXTILE FOR THE DELIVERY OF THERAPEUTIC NEGATIVE PRESSURE AND COMPRESSIVE FORCES TO A TREATMENT SITE - A system for applying negative pressure to a joint positioned in a treatment area. The system includes a negative pressure dressing. The negative pressure dressing includes a compressive layer and a sealing layer. The compressive layer includes a first surface and a second, treatment area-facing. The compressive layer further includes a first elongated portion configured to be positioned proximate the joint. The first elongated portion includes a first end and a second end. The compressive layer further includes a second elongated portion spaced from the first elongated portion and configured to be positioned proximate the joint. The second elongated portion includes a first end and a second end. The compressive layer further includes an interconnecting portion extending between the first elongated portion and the second elongated portion. The interconnecting portion is configured to overlie at least a portion of the joint. The compressive layer further includes a plurality of channels formed in the first surface and extending proximate the second surface. The plurality of channels is formed in at least one of the first end and the second end of the first elongated portion and at least one of the first end and the second end of the second elongated portion. The sealing layer is configured to form a seal around a perimeter of the negative pressure dressing. | 2021-05-06 |
20210128805 | AN APPARATUS CONFIGURED TO BE USED WITH A BREAST PUMP DEVICE - The invention relates to an apparatus ( | 2021-05-06 |
20210128806 | HEMODIALYSIS SYSTEM RESERVOIR LEVEL SENSOR - A portable hemodialysis system is provided including a dialyzer, a closed loop blood flow path which transports blood from a patient to the dialyzer and back to the patient, and a closed loop dialysate flow path which transports dialysate through the dialyzer. In addition, the hemodialysis system includes two reservoirs which can be alternately placed in the dialysis flow path using various controllable fluid valves. The weight, and therefore the level of dialysate, of each reservoir is measured by a preferred level sensor having a lever arm, a load cell, and a tilt sensor. The load cell and tilt sensor are electrically connected to a processor for sending force and tilt measurements to the processor. The processor may analyze the tilt measurements to correct for any inaccurate measurements of the load cell caused by the tilt. | 2021-05-06 |
20210128807 | HEMODIALYSIS SYSTEM INCORPORATING DIALYSATE GENERATOR - A portable hemodialysis system is provided including a dialyzer, a closed loop blood flow path which transports blood from a patient, to the dialyzer, and back to the patient, and a closed loop dialysate flow path which transports dialysate through the dialyzer. The hemodialysis system includes a hemodialysis machine and dialysate generator which are physically connectable to, and disconnectable from, one another. To connect the hemodialysis machine and dialysate generator together, both the hemodialysis machine and dialysate generator possess connectable and disconnectable electrical connectors and fluid connectors which are positioned and constructed to allow both a fluid and electrical connection between the two machines. The hemodialysis machine includes a processor and a user interface, preferably in the form of a touchscreen, that is capable of controlling both the functions of the hemodialysis machine and the dialysate generator. | 2021-05-06 |
20210128808 | DISPOSABLE CARTRIDGE AND PUMP TRACK MECHANISM - Disclosed are example embodiments of a dialysis machine having a frame, a cartridge cassette, one or more alignment-locking features, and an actuation mechanism. The frame is fixedly coupled to the dialysis machine, and the cassette is slidably coupled to the frame. The cassette can have one or more track structures, with each of the one or more track structures having a rotor and one or more rollers. The one or more alignment-locking features extend from the frame and are configured to be inserted into one or more alignment features of a disposable cartridge that functions to secure or release the disposable cartridge. The actuation mechanism is made to slide the cassette with respect to the one or more track structures. | 2021-05-06 |
20210128809 | MEASURING FLUID FLOW ASSOCIATED WITH A DIALYSIS MACHINE - A dialysis machine (e.g., a peritoneal dialysis (PD) machine) can include a control unit configured to monitor an amount of fluid withdrawn from a heater bag line during a PD treatment. A processor in the control unit is configured to operate a first pump to draw fluid into a first pump chamber and measure a first fluid volume in the first pump chamber. The processor is further configured to operate the first pump and a second pump to transfer fluid from the first pump chamber to a second pump chamber, measure a second fluid volume in the second pump chamber, and determine a measured fluid volume for a single pump cycle based on the first fluid volume and the second fluid volume. The first fluid volume is correlated to the second fluid volume and, therefore, the multiple independent measurements increase an accuracy of the fluid volume measurement. | 2021-05-06 |
20210128810 | CLEANING OF BIOLOGICAL FLUID - The present invention relates to removal of protein bound deleterious substances from an extracorporeal biological fluid by changing the affinity of the substance to the protein. The invention relates to the use of displacer substances for removal of deleterious substances. The present invention also relate to a method of removal, a system, a cleaning fluid comprising the displacer substances for removal of deleterious substances. | 2021-05-06 |
20210128811 | Therapeutic Plasma Exchange Systems and Methods - Systems and methods for performing therapeutic plasma exchange are provided. The systems and methods utilize a plasmapheresis device that includes a controller that is configured and/or programmed to monitor the amount plasma collected and initiate delivery of a therapeutic agent. | 2021-05-06 |
20210128812 | Flow Balancing Devices, Methods, and Systems - The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described. | 2021-05-06 |
20210128813 | SYSTEM AND METHOD FOR EXTRACORPOREAL CARBON MONOXIDE REMOVAL WITH PHOTOTHERAPY - Systems and methods for removing carbon monoxide from whole blood are provided. In one configuration, an extracorporeal phototherapy system includes an oxygenator and a light source configured to output light and arranged to emit the light output by the light source onto at least one surface of the oxygenator. The oxygenator includes a plurality of membrane layers each having a plurality of microporous hollow fiber membranes. The plurality of microporous hollow fiber membranes each include an external surface and an internal channel. Each of the plurality of membrane layers may be rotationally offset with respect to an adjacent layer. The oxygenator further includes a gas inlet port in fluid communication with a first end of the internal channels, a gas outlet port in fluid communication a second end of the internal channels, a blood inlet port, and a blood outlet port. | 2021-05-06 |
20210128814 | Ternary phased medical procedural process for fracturing a lipid membrane of a viral pathogen that is infecting a patient's pulmonary system and purging the viral pathogen from the patient's pulmonary system (FLiM) - Ternary phased medical procedural process for fracturing and cleansing a viral pathogen from a pulmonary system, (FLiM) of a patient that has tested positive for a pulmonary viral pathogen, and the viral pathogen's constitution consisting of a lipid membrane, for example, the viral pathogen Covid19, by means of a FLiM performed by a Medical Professional (MP), utilizing potential permutations, “MD/S (nPk) x ELT (nPk)” and of at least: a continuous aqueous suspension, herein understood as; a Microcrystalline Castile Colloid (MCC), at least one medical device, a medically equipped operating theater, at least one computer and a network, and comprised of at least the steps of: diagnosing, determining, prepping, performing, diagnosing and following-up on the patient for FLiM medical procedure process. | 2021-05-06 |
20210128815 | SYSTEM AND METHOD FOR MONITORING FLUID DEFICIT - A fluid management and medical device system may include a fluid management system and a medical device having one or more sensors proximate the distal end of the elongate shaft of the medical device. The controller of the fluid management system may be configured to calculate a fluid deficit when the distal end of the elongate shaft is disposed within a patient and configured to automatically pause fluid deficit calculation when the distal end of the elongate shaft is removed from the patient. In some instances the controller is configured to calculate the fluid deficit using rotational speed of the inflow pump in combination with a difference between a change in weight of a fluid supply source supplying fluid to the fluid management system and a change in weight of a collection container collecting fluid from the fluid management system. | 2021-05-06 |
20210128816 | BALLOON DILATION CATHETER SYSTEM FOR TREATMENT AND IRRIGATION OF THE SINUSES - A medical device for the treatment and irrigation of a sinus opening is described. The device allows for single-handed operation to access, dilate and irrigate a sinus opening. The device includes a sinus guide catheter, a guiding element, a balloon dilation catheter, a balloon catheter movement mechanism and a guiding element movement mechanism. A method for treating a sinus opening and irrigating a sinus is also described. | 2021-05-06 |
20210128817 | NEEDLE UNIT WITH BIOSTATIC CHAMBER - The present invention provides a needle unit ( | 2021-05-06 |
20210128818 | METHODS AND SYSTEMS FOR TIMING A SECOND CONTRAST BOLUS - Methods and systems are provided for adaptive scan control. In one embodiment, a method includes upon a first contrast injection, processing acquired projection data of a subject to measure a contrast signal of the first contrast injection, estimating a time when a venous return to baseline (VRTB) of the first contrast injection is to occur based on the contrast signal, and commanding initiation of a second contrast injection at the estimated time. | 2021-05-06 |
20210128819 | COMPOSITIONS, DEVICES AND KITS FOR SELECTIVE INTERNAL RADIATION THERAPY - Systems, kits and methods for preparing an injection system and/or treating target lesions with a selective internal radiation therapy which includes a double-barrel syringe loaded with a two-component tissue glue and radioisotope loaded microspheres. The microspheres are loaded into the syringe based on the size of the target location and are administered with a needle or dual-lumen catheter. Dosing regimens for treating breast cancer lesions or surgical beds up to 130 mm in diameter and hepatocellular carcinoma lesions up to 50 mm are included. | 2021-05-06 |
20210128820 | METHODS AND SYSTEMS FOR ADAPTIVE TIMING OF A SECOND CONTRAST BOLUS - Methods and systems are provided for adaptive scan control. In one embodiment, a method includes, upon a first contrast injection of a first contrast bolus, processing acquired projection data of a subject to measure a contrast signal of the first contrast bolus, setting a timing for a second contrast injection of a second contrast bolus to a fallback injection timing, and responsive to identifying an adaptive injection timing for the second contrast injection based on the contrast signal before the fallback injection timing is reached, updating the timing for the second contrast injection to the adaptive injection timing and commanding initiation of the second contrast injection at the adaptive injection timing, otherwise commanding initiation of the second contrast injection at the fallback injection timing. | 2021-05-06 |
20210128821 | EMERGENCY MEDICAL INTERVENTION DEVICE - A therapeutic device for treating an acute medical condition of a patient such as cardiac arrest is provided. The device includes one or more sensors that monitor parameters such as heart rhythm that relate to the patient's medical condition. The device also includes a plurality of medication reservoirs, each reservoir including a conduit, wherein each reservoir holds a predetermined medication that may be used to treat the condition. A manifold is connected with the reservoirs via their respective conduits. A delivery line is connected with the manifold to deliver fluids from the manifold to the patient intravenously. One or more medication pumps are in fluid connection with respective ones of the reservoirs. A processor is connected with the sensors. The processor includes a memory that stores processing instructions to interpret the parameters and to determine a recommended medication to deliver to the patient based on the parameters, the recommended medication being one of the predetermined medications. The processor is operatively connected with the medication pumps. When a recommended medication is determined, the processor actuates the medication pump connected with the reservoir including the recommended medication to deliver the medication to the patient via the manifold and the delivery line. | 2021-05-06 |
20210128822 | IMPROVED INTRAVENOUS INFUSION SET - An improved intravenous infusion set ( | 2021-05-06 |
20210128823 | SELECTIVELY MECHANICALLY ACTIVATABLE PREFILLED INFUSION-PUMP DEVICES - This invention provides a prefilled selectively activatable body-worn infusion-pump assembly for rapid delivery of large volumes or highly viscous volume comprising a housing; a pre-filled aseptically-sealed flexible drug reservoir-containing assembly; a conjoined, coordinately controlled and perpendicularly arranged cannulated needle dispensing and needle insertion assembly operationally connected to and in fluid connection with the pre-filled aseptically-sealed drug reservoir-containing assembly, wherein the cannulated needle dispensing assembly projects generally perpendicularly to a generally planar surface of the housing, promotes insertion of the cannulated needle in skin of a subject and promotes retraction of the needle within the cannulated needle dispensing assembly thereafter, and wherein the needle insertion assembly projects generally in a parallel orientation to a generally planar surface of the housing, which projection initiates opening a fluid path with the pre-filled aseptically-sealed drug reservoir-containing assembly; an engine assembly contained in the housing operationally connected to the pre-filled aseptically-sealed flexible drug reservoir-containing assembly promoting release of a drug contained therein, wherein the engine assembly comprises: a motor; a worm gear, operationally connected to the motor; a lifting gear, operationally connected to the worm gear; a piston operationally connected to the lifting gear; and a chassis fitted with an attachment promoting a floating connection thereto with the worm gear; wherein the worm gear and motor are mounted radially with respect to the chassis; a printed circuit board (PCB) assembly, which mechanically supports, electrically connects and controls the function of at least the engine assembly; and a single step activator that when engaged simultaneously promotes activation of the needle insertion assembly opening a fluid path with the pre-filled aseptically-sealed drug reservoir-containing assembly; activation of the engine assembly; and activation of the cannulated needle dispensing assembly inserting in a skin of a subject. | 2021-05-06 |
20210128824 | COMPONENT POSITIONING OF A LINEAR SHUTTLE PUMP - Disclosed herein are wearable drug delivery devices and methods for component positioning of a linear shuttle pump. In some approaches, a pump may include a pump chamber operably coupled with a piston, and a detent apparatus, wherein the detent apparatus comprises a detent body, a detent arm, and a detent engagement member. The detent engagement member may be retained in direct physical contact with first or second arrest locations of either the detent body or the detent arm. The pump may further include a piston grip coupled to the piston, the piston grip including a grip component engaged with an exterior of the piston. Movement of the piston grip may cause the piston to move axially relative to the pump chamber to control receipt and delivery of a liquid drug. | 2021-05-06 |
20210128825 | SYSTEM AND METHOD OF PAIRING AN INFUSION PUMP WITH A REMOTE CONTROL DEVICE - Embodiments of the present disclosure enable a user-wearable infusion pump that may have a limited user interface including no display to be paired with a remote control device that can include a remote consumer electronic device such as a smartphone and/or a dedicated remote controller. | 2021-05-06 |
20210128826 | DRIVING STRUCTURE AND INJECTION MACHINE - A driving structure and an injection machine are disclosed. The driving structure includes: a driving device, a first swinging assembly and a second swinging assembly, the first swinging assembly and the second swinging assembly both comprise a swinging block and a moving block, the swinging block is in contact with the moving block, the swinging block of the first swinging assembly and the swinging block of the second swinging assembly are both connected with an output end of the driving device, the swinging block in the same swinging assembly is configured to drive the moving block to move, and a working stroke of the moving block in the first swinging assembly and a working stroke of the moving block in the second swinging assembly are carried out at intervals. | 2021-05-06 |
20210128827 | KIT AND METHOD OF REDUCING HUMAN ERROR DURING IMPLANTED INFUSION PUMP REFILLING - Method of safely refilling an implanted infusion pump. The method includes contacting a withdrawn fluid with a protein-detecting composition, detecting whether the protein-detecting composition experiences a reaction, and performing a refilling procedure if no reaction is detected. | 2021-05-06 |
20210128828 | METHOD AND APPARATUS FOR TREATMENT OF INTRACRANIAL HEMORRHAGES - An ultrasound catheter with a lumen for fluid delivery and fluid evacuation, and an ultrasound source is used for the treatment of intracerebral or intraventricular hemorrhages. After the catheter is inserted into a blood clot, a lytic drug can be delivered to the blood clot via the lumen while applying ultrasonic energy to the treatment site. As the blood clot is dissolved, the liquefied blood clot can be removed by evacuation through the lumen. | 2021-05-06 |
20210128829 | DELIVERY DEVICE AND ADSORBENT - A delivery device ( | 2021-05-06 |
20210128830 | CONTROLLED DELIVERY DRIVE MECHANISMS FOR DRUG DELIVERY PUMPS - A controlled delivery drive mechanism includes a drive housing, a piston, and a biasing member initially retained in an energized state and is configured to bear upon an interface surface of the piston. The piston is configured to translate a plunger seal and a barrel. A tether is connected between the piston and the winch drum to restrain the free expansion of the biasing member and the free axial translation of the piston upon which the biasing member bears upon. The drive mechanism may further include a gear assembly and an escapement regulating mechanism configured to control the rotation of the gear assembly to release the tether from the winch drum. The metering of the tether by the escapement regulating mechanism controls the rate or profile of drug delivery to a user. | 2021-05-06 |
20210128831 | SYSTEMS AND METHODS FOR DETERMINING PLACEMENT OF WEARABLE DRUG DELIVERY DEVICES - A wearable drug delivery device and method for optimizing performance thereof are provided. A system may include a processor operable with memory, and a drug delivery device and sensor coupled to a user, the sensor operable to detect characteristics of the delivery device. A receiver operable on the processor receives an input signal from the sensor, the input signal representing the detected characteristics. A controller operable on the processor receives the input signal from the receiver, and retrieves, from memory, a baseline characteristics. The controller may determine a location of the delivery device and a tissue profile of the injection location based on a comparison between the detected characteristics and the baseline characteristics. The controller may further control or modify delivery of a liquid drug from the delivery device in response to the location of the delivery device. | 2021-05-06 |
20210128832 | HIERARCHICAL ADAPTIVE CLOSED-LOOP FLUID RESUSCITATION AND CARDIOVASCULAR DRUG ADMINISTRATION SYSTEM - The present disclosure describes a closed-loop fluid resuscitation and/or cardiovascular drug administration system that uses continuous measurements and adaptive control architecture. The adaptive control architecture uses a function approximator to identify unknown dynamics and physiological parameters of a patient to compute appropriate infusion rates and to regulate the endpoint of resuscitation. | 2021-05-06 |
20210128833 | SYSTEM AND METHOD FOR DETECTING ISSUES IN THE BASAL RATE IN INSULIN TREATED DIABETES PATIENTS - A system for determining a deficiency in an infusion rate for a user has a processor, a display, a memory and, optionally, one or more of a pump and an analyte monitor. The processor receives measured glucose values that each have a timestamp indicating the time/date of measurement. The processor determines whether the glucose values include n pairs of glucose values g0 | 2021-05-06 |
20210128834 | INFUSION DEVICES AND RELATED RESCUE DETECTION METHODS - Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device to deliver fluid to a body of a user involves obtaining measurement values for a physiological condition influenced by the fluid, autonomously operating the infusion device to deliver the fluid based at least in part on the measurement values, and detecting a nonactionable condition based on the measurement values. In response to detecting the nonactionable condition, delivery of the fluid is limited while maintaining autonomous operation of the infusion device. In one exemplary embodiment, the nonactionable condition is a rescue condition indicative of the user having consumed fast-acting carbohydrates, and thus insulin delivery may be automatically limited in response to detecting the rescue carbohydrate consumption. | 2021-05-06 |
20210128835 | SYSTEMS AND METHODS FOR PRE-FILLED DUAL-CHAMBER MEDICAL AGENT DELIVERY - A pre-filled dual-chamber medical agent delivery system assembled and configured to allow delivery of a single dose of a combined therapeutic agent (e.g., vaccine, drug, medicament, etc.) from a Blow-Fill-Seal (BFS) vial to a patient. The delivery assembly generally includes a modular design consisting of separately constructed components cooperatively arranged and coupled to one another, such as to facilitate delivery of a reconstituted lyophilized agent to a patient. | 2021-05-06 |
20210128836 | POWER UNIT FOR USE IN AN AUTOINJECTOR AND METHOD OF ASSEMBLING SUCH POWER UNIT - A power unit ( | 2021-05-06 |
20210128837 | AUDIBLE INDICATOR - The disclosure relates to an audible indicator for use with a drug delivery device comprising a bistable resilient force member capable of residing in two states. In a biased state, the resilient force member is biased and stores energy In a relaxed state, the resilient force member is relaxed. The resilient force member releases the stored energy when transitioning from the biased state into the relaxed state, thereby generating an audible signal. | 2021-05-06 |
20210128838 | CARTRIDGE HOLDER AND MEDICINE INJECTION DEVICE COMPRSING THE SAME - According to an embodiment, there are provided a cartridge holder and a medicine injection device including the cartridge holder. The cartridge holder comprises a holder case having an insertion space in which a cartridge is inserted, a cross section of the holder case, perpendicular to a lengthwise direction thereof, having a ring shape and a cartridge support connected to the holder case, the cartridge support supporting an outer surface of the medicine cartridge inserted in the insertion space to fix the medicine cartridge. The cartridge support may allow a cross sectional center of the medicine cartridge to match a cross sectional center of the holder case and aligns the medicine cartridge, with the medicine cartridge placed in the insertion space. | 2021-05-06 |
20210128839 | Planar Micro Injector with Securing Lanyard and a Circumferential Flexible, Collapsible Ring Constructed of Thin Film - A generally planar micro injector with a securing lanyard is disclosed. The micro injector is constructed of an elastic ampoule with a flexible actuation area affixed to a thin base unit through which an injector needle is plumbed. The micro injector is secured to the hand with an adhesive layer and an affixed securing lanyard and has a flexible, collapsible ring constructed of thin film circumferentially attached around its base. The flexible, collapsible ring is filled with anesthetic gel and extends beyond the tip of the needle. | 2021-05-06 |
20210128840 | STRETCHABLE PLUNGER ASSEMBLIES - Disclosed are plunger assemblies which include a plunger sleeve, a plunger rod and an axial protrusion disposed within an inner cavity of the plunger sleeve. Application of a distal force onto the plunger via the plunger rod causes the axial protrusion to contact and apply pressure to an engagement surface in the inner cavity. The engagement surface is configured to receive distal force from the end of the axial protrusion. This causes the plunger to elongate and slightly constrict, thus reducing break loose force and facilitating transition from storage mode to dispensing mode of the plunger. | 2021-05-06 |
20210128841 | A ROTARY DOSAGE SENSING MODULE FOR AND IN A DISPOSABLE PEN DRUG DELIVERY DEVICE - A dosage sensing module for or in a pen drug delivery device and comprising a power source unit, a processor unit and a dosage sensor unit with a first sensor part adapted to be fixed to a part not rotating during dose expelling and comprising a flexible printed circuit board sheet on which a pattern of individual electrical conductive sensor areas are arranged. The sensor unit further comprises a second sensor part adapted to be fixed to the piston rod to follow the rotation thereof during dose expelling. The second sensor part comprises individual structures that together with the conductive sensor areas are adapted to, upon relative rotational movement between the first and second sensor part, provide electrical signals to a processor unit indicative of the relative rotational position between the first and second sensor part. | 2021-05-06 |
20210128842 | AUTOINJECTOR APPARATUS - An autoinjector apparatus is disclosed which comprises a single-use cassette and an autoinjector. The cassette comprises a housing and a sleeve movably disposed in the housing. A syringe may be disposed in the sleeve and secured therein with a lock cap. The lock cap is affixed to a distal end of the sleeve and contacts the distal end of the syringe. A shield remover extends through an opening in a proximal end of the housing for removing a needle shield which covers a needle of the syringe. A cassette identification arrangement is provided on a surface of the housing to enable the autoinjector to identify the cassette. The autoinjector is provided with a detector for reading the cassette identification arrangement. | 2021-05-06 |
20210128843 | TIP FOR INTRA-TYMPANIC INJECTION - Provided is a tip for intra-tympanic injection capable of allowing a practitioner to accurately recognize an injection location and preventing the practitioner from piercing regions of an external auditory meatus other than the eardrum with an injection needle, in case of piercing the eardrum with the injection needle. | 2021-05-06 |