| 18th week of 2010 patent applcation highlights part 52 |
| Patent application number | Title | Published |
|---|
| 20100112518 | Conditioning Agent and Method for Binding Hardenable Mixtures to Moulded Bodies Made of Filled High-Temperature Resistant Plastics - The invention describes a conditioning medium, the use thereof in mediating in the adhesion of a hardenable mixture to a shaped article, and a method of pretreating the surfaces of shaped articles made of filler-containing high-temperature-resistant plastics for the purpose of better adhesion of hardenable mixtures to those shaped articles, and also the method products resulting therefrom, especially conditioned shaped articles. | 2010-05-06 |
| 20100112519 | IMPLANT, METHOD FOR PRODUCING THE IMPLANT, AND USE OF THE IMPLANT - An implant comprises titanium and has one or more surfaces which can be applied in or on a bone growth area. One or more of the surfaces are arranged with a depot for bone-growth-initiating or bone-growth-stimulating substance, in which the depot is formed by a pore arrangement in a relatively thick oxide layer on the titanium. The substance is acted on, for a considerable period of time, by one or more release functions for the substance which permit a controlled or optimized release of substance to the surrounding tissue or bone growth area. | 2010-05-06 |
| 20100112520 | Dental implant system - The dental implant system includes implants having integral abutments therewith for the removable or fixed attachment of plural or single prosthetic teeth, as appropriate. The system for removable dental prostheses includes a metal housing permanently installed in the removable prosthesis, and a rubber retentive insert installed in the housing. The insert is removably installed over the abutment of the implant to secure the dental prosthesis thereto. The system includes transfer copings for transferring an impression to the lab for manufacture of the prosthesis, and lab processing copings and analogs for handling and forming the prosthesis during manufacture. The system may be assembled as a kit having some or all of the above components. | 2010-05-06 |
| 20100112521 | DENTAL ABUTMENT ANALOG FOR IMPLANT-SECURED RESTORATION - An abutment analog for fabricating an implant-based dental restoration includes an abutment base which is fixed within a patient's mouth in an angularly indexed fashion. After an impression is made, an implant analog will be attached to the abutment analog, and the combined abutment analog and implant analog will be replaced within the impression. The resulting impression, including the abutment analog and attached implant analog, will be used to make a model of a patient's mouth structure, to permit fabrication of a dental restoration device in a laboratory. | 2010-05-06 |
| 20100112522 | Mesh Plate for Dental Implant and Dental Implant Structure Having the Same - Provided is a dental implant structure for recovering or improving function of a lost or damaged tooth. A mesh plate | 2010-05-06 |
| 20100112523 | CONDENSING SKELETAL IMPLANT THAT FACILITATE INSERTIONS - A dental implant that facilitates insertion includes a body having a coronal end and an apical end opposite the coronal end. An implant-prosthetic interface region is provided adjacent the coronal end. A tapered region is adjacent the apical end. A variable profile helical thread extends along the tapered region. The thread becomes broader in the apical-coronal direction and higher in the coronal-apical direction. The threads include an apical side, a coronal side and a lateral edge connecting them. The variable profile thread includes an expanding length of the lateral edge while the distance of the lateral edge from the base is reduced in the direction of the coronal end. The implant also has a gradual compressing tapered core, a self drilling apical end with a spiral tap, and a coronal end with and inverse tapering. | 2010-05-06 |
| 20100112524 | Method for producing a functional prosthesis - The invention relates to a method for producing a functional prosthesis as a provision for a jaw region, allowing for the procedural steps of taking a dental impression of the jaw region to be provided with the functional prosthesis, producing a preliminary structure and possibly testing the preliminary structure in an articulator, and producing the functional prosthesis on the basis of the possibly re-worked preliminary structure. In order to produce a functional prosthesis by incorporating a preliminary structure, in which a functional analysis of the stomatognathic system can be taken into account, it is proposed that the preliminary structure be manufactured of a markable material with a hardness H that corresponds to 90% to 100% of the hardness of at least one natural or refurbished tooth of an antagonist of the jaw region, that the preliminary structure subsequently be integrated into the jaw region and remain in the jaw region for a wearing period of approximately 5 to 30 day, that the preliminary structure subsequently be removed and thereupon the functional prosthesis be manufactured taking into consideration any changes the preliminary structure underwent during its wearing. | 2010-05-06 |
| 20100112525 | METHODS AND SYSTEMS FOR PROGRESSIVELY TREATING AND CONTROLLING ORAL PERIOPATHOGENS CAUSING SYSTEMIC INFLAMMATIONS - Methods and systems for treating and controlling oral periopathogens that have been found to be associated with systemic inflammation and/or disease in a periodontal pocket, inhibiting their entry into the host circulatory system, and decreasing the systemic effects. A bacterial community present in one or more oral treatment regions is determined. A periodontal medicament delivery tray is prepared for the patient with the delivery tray being configured with one or more application regions, each configured for applying a medicament to a different one of the oral treatment regions. The medicaments are applied to each oral treatment region, including placing each medicament into a different application region of the delivery tray. Each of the applied medicaments is applied as a function of a determined efficacy of the medicament against the bacterial community determined to be in the oral treatment region associated with the application region in which each medicament is applied. | 2010-05-06 |
| 20100112526 | ARTICLE AND METHOD FOR CONTROLLING ORAL-ORIGINATED SYSTEMIC DISEASE - Systems and methods for treating gingival tissue or oral biofilm includes applying to the gingival tissue (sulcus or periodontal pocket) a biofilm penetrating antimicrobial agent; removing the imbedded anaerobic bacteria from the gingival tissue following at least one applying of the antimicrobial agent to the gingival tissue; administering colloidal hydrogen peroxide gel to the gingival tissue following the removing of imbedded anaerobic bacteria; and cleaning the gingival tissue with a cleaning agent directly following the administering of the colloidal hydrogen peroxide gel for modifying the environment from anaerobic (diseased) to aerobic (healthy). | 2010-05-06 |
| 20100112527 | METHOD FOR FABRICATING AN IMPLANTED DENTAL RESTORATION - A method for fabricating an implant-based dental restoration includes attaching an abutment analog to a dental implant contained in a patient's mouth in an angularly indexed fashion. After an impression is made, an implant analog will be attached to the abutment analog, which is contained within the impression, and the assembled impression, including the abutment analog, including an impression coping and abutment base, will be employed along with the implant analog to make a model of a patient's mouth structure, including thread-timed implant analogs, to permit fabrication of an angle-corrected dental restoration device in a laboratory. | 2010-05-06 |
| 20100112528 | Human behavioral simulator for cognitive decision-making - A simulator is disclosed for training a responder to react in situations that have the potential for the use of force when encountering a main character, such as a person, whom a police officer might encounter during a routine stop and search. The simulator is equipped with natural language recognition and processing such that the main character reacts to voice commands from the trainee. In addition, feedback from the weapon and the weapon aimpoint alters the behavior of the main character. The dynamic scenario architecture is responsive to the language and weapon and interacts with the main character to affect the main character's behavior. The main character is equipped with a behavioral model to vary behavior in a given scenario. | 2010-05-06 |
| 20100112529 | Safe driving evaluation system and safe driving evaluation program - Safety driving evaluation systems, methods, and programs count a frequency of a braking operation of a vehicle and determine whether each braking operation is a sudden braking operation. The systems, methods, and programs calculate a sudden braking percentage. The systems, methods, and programs determine whether a vehicle deceleration frequency is low for a road where the sudden braking occurred, and correct the sudden braking percentage to a higher value if the vehicle deceleration frequency is determined as low. The systems, methods, and programs acquire evaluation information based on the sudden braking percentage. | 2010-05-06 |
| 20100112530 | Real-time interpreting systems & methods - Systems, methods and computer program products for the provision and enabling of multi-language and sign language services in real-time are disclosed. System components include a call processing computer/server that receives requests and is in communication with other system components, a video server/computer for processing and relaying video images, user interface devices for making requests and receiving data transmitted between system components and service provider devices for responding to or satisfying requests received. | 2010-05-06 |
| 20100112532 | CARD-TYPE LEARNING TOOLS, LEARNING APPARATUSES, PROGRAMS FOR LEARNING APPARATUSES, AND RECORDING MEDIA THEREFOR - An offensive player operates input means ( | 2010-05-06 |
| 20100112533 | System and method of training by providing motional feedback - A method is generally described which includes providing training by altering a user's motional response includes directing a user to perform specified motions in accordance with a training sequence and detecting the user's motions, by a feedback sensor device, the motions associated with the user. The method also includes generating, by the control program, control data based on the data representative of the detected motions and the training sequence. The control program is configured to receive data representative of the detected motions and to receive the training sequence. The control program has a control algorithm configured to generate control data based on the data representative of the detected motions and the information. Further, the method includes running the control program by a controller configured to output control signals based on the control data. Further still, the method includes delivering current, during a repeating phase in which the user is attempting to repeat the training sequence, from the current source to a vestibular stimulation device configured to deliver a stimulation current to at least one electrical contact, in response to the control signals. The at least one electrical contact is configured to contact flesh of the user. | 2010-05-06 |
| 20100112534 | Board Sport Training Apparatus - Disclosed herein is a portable apparatus for training a user in increasing levels of skill, control and maneuverability of a board for a board sport. The portable apparatus comprises a foot placement mat and a support unit. The foot placement mat comprises multiple placement zones for indicating a first location for positioning a support unit and second locations for placing the user's feet. The support unit comprises laterally opposite support members and hand placement platforms. Each of the laterally opposite support members comprises an elongated section and a lower protruding section. The hand placement platforms are detachably attached to the elongated section or the lower protruding section of the laterally opposite support members for enabling placement of the user's hands in an elevated position or a lower position respectively. The support unit positioned on the foot placement mat enables the training of the user in increasing levels of skill, control and maneuverability of a board for a board sport. | 2010-05-06 |
| 20100112535 | System and method of altering motions of a user to meet an objective - A method is generally described which includes detecting motions associated with a user, by a feedback sensor device. The method of also includes receiving information by a control program, the information being related to an objective of the user's motion from an objective information source and receiving data representative of the detected motions by the control program. Further, the method includes generating control data based on the data representative of the detected motions and the information, by a control algorithm of the control program. Further still, a method includes running the control program by a controller. Yet further still, the method includes outputting control signals based on the control data and delivering current from a current source to the vestibular system of the user in response to the control signals. | 2010-05-06 |
| 20100112536 | GROUP COACHING SYSTEM AND METHOD - Group coaching system, comprising at least a first and a second coaching device ( | 2010-05-06 |
| 20100112537 | Objects that interact with a user at a visceral level - Objects that interact with a user at a visceral level when the object comes within the user's personal environment. The objects detect a user's visceral behavior, for example breathing pattern or perspiration. In response to the visceral behavior the object simulates a behavior of a living entity such as breathing, or produces an output to which the user responds viscerally, such as an electric field. The form of the output or simulated behavior is determined by the visceral behavior. The output or simulated behavior may be modified to guide the user's visceral behavior, for example by first synchronizing simulated breathing to the user's breathing and then slowing down while the user's breathing is entrained to the simulated breathing. One such object has a skin that is warm to the touch, and simulates breathing with a breathing sound. Another such object produces electric fields like electric fields of the heart. A further such object simulates a purring sound in response to the user's breathing: the form of the purring also depends on sounds in the environment. | 2010-05-06 |
| 20100112538 | PHANTOM AND ITS MANUFACTURING METHOD - A phantom manufacturing method is disclosed, which comprises the steps of: disposing an exudate network with interconnecting first channel and second channel in a container in a manner that the first channel is transversely disposed for an exudate to flow laterally in the container and the top portion of the second channel is longitudinally disposed for the exudate to flow vertically in the container; forming a plurality of stacking solid layers while arranging the first channel at the bottommost solid layer and the top of the second channel at either inside the topmost solid layer or to be exposed outside the top of the topmost solid layer as the bottom of the second channel is connected to the first channel and extending therefrom upward to the topmost solid layer; and forming a recess in the topmost solid layer while connecting the bottom thereof to the second channel. | 2010-05-06 |
| 20100112539 | SELF-SCORING AND SELF-ANALYZING TEST ANSWER SHEET - Self-scoring and self-analyzing test answer sheet which facilitates grading and provides the grader with data concerning the nature of each question and the skill being tested. A skills summary area is provided for recording the total test score and also the number of incorrect responses for each of the specific skills tested. | 2010-05-06 |
| 20100112540 | SYSTEM AND METHOD OF EDUCATION UTILIZING MOBILE DEVICES - A wireless communication system is disclosed, using a server, a teacher computer, an administration computer, and wireless mobile device for delivering educational content to students. | 2010-05-06 |
| 20100112541 | Method for estimating examinee attribute parameters in cognitive diagnosis models - A method of determining a mastery level for an examinee from an assessment is disclosed. The method includes receiving one or more of an overall skill level for an examinee, a weight for the overall skill level, a covariate vector for an examinee, and a weight for the covariate vector. An examinee attribute value is computed using one or more of the received values for each examinee and each attribute. The computation of the examinee attribute values can include estimating the value using a Markov Chain Monte Carlo estimation technique. Examinee mastery levels are then assigned based on each examinee attribute level. Dichotomous or polytomous levels can be assigned based on requirements for the assessment. | 2010-05-06 |
| 20100112542 | Method and apparatus for controlling air pressure in an organ or tissue container - An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The apparatus and methods include the organ cassette with one or more openings configured to allow tubing to pass through the openings and be connected to the organ or tissue within the cassette, and including a pressure control device to allow pressure inside the portable housing to be varied. | 2010-05-06 |
| 20100112543 | PROCESSING SOFT TISSUE, METHODS AND COMPOSITIONS RELATED THERETO - In certain embodiments, the present invention relates to a process for preparing skin removed from a human donor, including a living human donor, and removing cellular components and forming a decellular matrix having as major components collagens and elastins while disinfecting the tissue. In other embodiments, the present invention relates to a process for treating a decellularized soft tissue by freezing the same at a plurality of decreasing temperatures at atmosphere or higher such that there is formation of ice crystals having a size greater than 2.0 and lyophilizing the soft tissue under vacuum to remove the water to less than 6% forming a porous matrix. | 2010-05-06 |
| 20100112544 | MODIFIED ROUTES OF LIPID METABOLISM, MEASURING OXIDIZED LDL AFTER FAT LOADING - The present invention relates to monitoring of lipid metabolism and is, particularly, directed to a test for estimating the individual susceptibility of a subject to the effect of oxidized dietary lipids. A high calorie and high fat meal were given to subjects and postprandial levels of oxidized low-density lipoproteins (LDL) were measured in the plasma of the subjects, indicating susceptibility to atherosclerotic events and insulin resistance. Food were also analysed for peroxide lipid content indicating LDL oxidizing potential of said foodstuff in a subject after consumption. | 2010-05-06 |
| 20100112545 | TRANS-1,2-DIPHENYLETHLENE DERIVATIVES AND NANOSENSORS MADE THEREFROM - Novel trans-1,2-diphenylethylene derivatives are synthesized which can be used to form nanoparticles-monomer-nanomolecule-receptor nanosensors. These trans-1,2-diphenyl-ethylene derivatives are soluble in both water and organic solvents, highly fluorescent and can be synthesized in high yields. The trans-1,2-diphenylethylene derivatives are bonded to a nanoparticle, a nanomolecule bonded to the derivative and a receptor bonded to the nanomolecule to form a nanosensor that can be used to detect chemical and biological agents. | 2010-05-06 |
| 20100112546 | NANOSCALE SENSORS - Various aspects of the present invention generally relate to nanoscale wire devices and methods for use in determining analytes suspected to be present in a sample, and systems and methods of immobilizing entities such as reaction entities relative to nanoscale wires. In one aspect, a nucleic acid, such as DNA, may be immobilized relative to a nanoscale wire, and in some cases, grown from the nanoscale wire. In certain embodiments, the nucleic acid may interact with entities such as other nucleic acids, proteins, etc., and in some cases, such interactions may be reversible. As an example, an enzyme such as telomerase may be allowed to bind to DNA immobilized relative to a nanoscale wire. The telomerase may extend the length of the DNA, for instance, by reaction with free deoxynucleotide triphosphates in solution; additionally, various properties of the nucleic acid may be determined, for example, using electric field interactions between the nucleic acid and the nanoscale wire. In another aspect, the invention provides systems and methods for attaching entities such as nucleic acids, receptors such as gangliosides, or surfactants to a nanoscale wire, for example, using aldehyde-producing reactions or hydrophobic interactions. In some aspects, certain systems and methods of the present invention may be used to determine an analyte suspected to be present in a sample, for example, a toxin, a virus, or a small molecule. Systems and methods of using such nanoscale wires are disclosed in other aspects of the invention, for example, within a microarray. Still other aspects of the invention include assays, sensors, kits, and/or other devices that include such nanoscale wires, methods of making and/or using functionalized nanoscale wires (for example, in drug screening or high-throughput screening), and the like. | 2010-05-06 |
| 20100112547 | METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF INFLUENZA - The invention provides method and compositions for determining the presence and amount of an influenza virus in a sample including high risk strains of Influenza A. Also provided are methods for determining whether a subject is infected with a influenza virus, as well as, the type and strain of the influenza virus. The methods involve contacting a sample from the subject with a PDZ polypeptides (PDZ) and/or PDZ ligands (PL) and determining whether binding interactions occur between PDZ and PL. Assays for identifying anti-viral agents are also provided, as well as, methods for using the compositions to alter PDZ binding to PL in influenza infected cells. | 2010-05-06 |
| 20100112548 | KIT FOR DETECTING NON-PATHOGENIC OR PATHOGENIC INFLUENZA A SUBTYPE H5 VIRUS - Current methods for detecting influenza A subtype H5 virus, for example cell culture, haemagglutination-inhibition, fluorescent antibody and enzyme immunoassay, and reverse transcriptase polymerase chain reaction (RT-PCR) may have the disadvantages of low sensitivity and low specificity. Furthermore, such methods are relatively difficult to use, and may not be suitable for routine detection on a daily basis. The kit for detecting H5 virus of this invention may provide a user-friendly alternative that is relatively more sensitive and specific to H5 virus. The detection kit utilizes two specially designed primers A and B for the replication of H5 virus, and a specific capture probe for immobilizing the amplified viral RNA. An additional primer C is also designed for the detection of pathogenic H5 virus. The detection of H5 virus by the detection kit may be accomplished within one day if desired. | 2010-05-06 |
| 20100112549 | Microorganism Detection Method and Apparatus - Embodiments of the present invention relate to selective organism detection, and, more particularly to recombinant bacteriophages and the use of such recombinant bacteriophages to detect target bacteria and to detect specific nucleic acid sequences within said target bacteria thus allowing for the detection of phenotypic characteristics of said bacteria such as determining drug(s) to which such target bacteria are resistant. The present invention further relates to sample preparation apparatuses for preparing samples for detection and analysis using bacteriophage-based techniques, that are low in cost, easy to use, and do not require technical expertise or any additional laboratory infrastructure to perform. | 2010-05-06 |
| 20100112550 | Microfluidic Assay for Characterization of the Leukocyte Adhesion Cascade - An apparatus and method for identifying and screening for agents affecting the leukocyte adhesion cascade (LAC) encompassing rolling, adhesion and migration comprises an optically clear, plastic microfluidic chip comprising flow channels with diameters in the range of 10-500 μm. The flow channels are coated with endothelial cells and at least a portion of the flow channels contains 1-30 μm sized openings, optionally filled with a native or synthetic extracellular matrix, that allow leukocyte migration into one or more tissue spaces. | 2010-05-06 |
| 20100112551 | Approaches to identifying mutations associated with hereditary nonpolyposis colorectal cancer - The present invention relates to the field of genetic screening. More specifically, the described embodiments concern methods to screen multiple samples, in a single assay, for the presence or absence of mutations or polymorphisms in a plurality of genes. Approaches to screen for the presence or absence of mutations that are associated with Hereditary Nonpolyposis Colorectal Cancer (HNPCC) and approaches to design primers that generate extension products that facilitate the resolution of multiple extension products in a single lane of a gel or in a single run on a column are also provided. | 2010-05-06 |
| 20100112552 | NUCLEIC ACID-BINDING CHIPS FOR DETECTING NITROGEN DEFICIENCIES AS PART OF BIOPROCESS CONTROL - The invention relates to nucleic acid-binding chips for monitoring bioprocesses, specifically for detecting nitrogen deficiencies. Said chips carry probes that are sensitive to at least three of the following 50 genes: kdgR, citA, htrA, ycn1, yppF, trpB, ggt, alsR, glnA, nrgA, yciC, yvtA, nrgB, ycnJ, glnR, yvlA, yncE, yvlB, trpF, ydfS, trpD, ycnK, trpB, trpC, nasD, ycdH, nasC, nasB, trpE, pckA, nasF, yrkC, and tnrA or the homolgs to SEQ ID NO: 91, 41, 53, 19, 55, 47, 21, 17, 9, 85, 45, 49, 95, 63, 15, 93, or 81 at a maximum of 80 different probes that are specific of nitrogen metabolism. The invention also relates to the use of corresponding gene probes, especially on the aforementioned chips, to corresponding methods and possible uses. | 2010-05-06 |
| 20100112553 | LUCIFERASE GENE OPTIMIZED FOR USE IN IMAGING OF INTRACELLULAR LUMINESCENCE - The present invention provides a gene construct encoding pH insensitive luciferase for visualizing intracellular information, wherein an intracellular expression activity is higher compared with a gene construct of luciferase derived from a firefly. | 2010-05-06 |
| 20100112554 | NUCLEIC ACID LIGANDS TO COMPLEX TARGETS - The present invention relates to a nucleic acid ligands capable of binding to one or more target molecules in a complex mixture. | 2010-05-06 |
| 20100112555 | METHOD FOR THE DIAGNOSIS OF COLORECTAL CANCER - The object of the present invention refers to an in vitro method for diagnosing colorectal cancer based on the determination from a biological sample obtained from a subject, of promoter methylation status of at least one of the genes APC, RARB2 and p14 and, optionally, MGMT and p16. Likewise, object of the present invention is a kit for performing the method of the invention. | 2010-05-06 |
| 20100112556 | METHOD FOR SAMPLE ANALYSIS USING Q PROBES - A method of sample analysis is provided. In certain embodiments, the method may comprise: a) contacting a plurality of Q probes with a nucleic acid sample comprising a target polynucleotide under hybridization conditions to form a plurality of flap endonuclease substrates each comprising a Q probe and a site in the target polynucleotide; b) contacting the plurality of flap endonuclease substrates with a flap endonuclease under cleavage conditions to produce cleavage products, in which each of the Q probes of the flap endonuclease substrates is cleaved to produce cleavage products that include at least a first fragment that is hybridized with a site in the target polynucleotide and a second fragment that is linear and free in solution; and c) detecting at least one of the cleavage products. | 2010-05-06 |
| 20100112557 | METHOD FOR HIGH RESOLUTION MELT GENOTYPING - Various methods are described that provide for high resolution melt (HRM) genotyping. The embodiments include providing a locus specific primer and two allele specific primers each having a 5′ end with a short tail, providing a nucleic acid having a single nucleotide polymorphism (SNP) base located within 1-20 base pairs of the 3′ end of nucleic acid, hybridizing the locus specific primer and the allele specific primers to the nucleic acid, amplifying the sample using pyrophosphorolysis activated polymerization (PAP) PCR enzyme, and determining the Tm of the amplicons using HRM. In other embodiments, reactions mixtures and kits for HRM genotyping are provided and disclosed. These kits comprise a locus specific primer, one or more allele specific primers each having a 5′ end with a short tail, a nucleic acid, and a pyrophosphorolysis activate polymerization (PAP) PCR enzyme. | 2010-05-06 |
| 20100112558 | Probe Bead Synthesis and Use - The present invention relates to the field of methods and devices of miniaturized synthesis. More specifically, the present invention relates to the parallel synthesis of large number of different types of molecules and oligomers, such as oligonucleotides (oligos), peptides, lipids, carbohydrates, small ligand molecules, and other organic and inorganic molecules as probes for multiplexing assays. The probes may be synthesized from and/or attached to nanobeads to microbeads. The present invention provides for assays of multiplexing large scale biology, such as analysis of genomic DNAs and RNAs and proteomic proteins or peptides performed simultaneously on the synthetic beads. | 2010-05-06 |
| 20100112559 | PRIMER SET FOR AMPLIFYING OBESITY GENE, REAGENT FOR AMPLIFYING OBESITY GENE CONTAINING THE SAME, AND THE USES THEREOF - Primer sets for amplifying target regions containing sites to be detected in the obesity gene (the β2AR gene, the β3AR gene, and the UCP1 gene) by a gene amplification method are provided, wherein the primer sets can amplify the regions specifically. Three pairs of primer sets are used including forward primers composed of the base sequences of SEQ ID NO: 9 or SEQ ID NO: 109, SEQ ID NO: 25, and SEQ ID NO:43 as well as reverse primers composed of the base sequences of SEQ ID NO: 18, SEQ ID NO: 30, and SEQ ID NO: 63, respectively. The use of these primer sets makes it possible to specifically amplify a target region including a site where a polymorphism to be detected is generated in the β2AR gene, the β3AR gene, and the UCP1 gene, in the same reaction solution at the same time. | 2010-05-06 |
| 20100112560 | MECHANISM TO SIGNAL RECEPTOR-LIGAND INTERACTIONS WITH LUMINESCENT QUANTUM DOTS - Semiconductor quantum dots are becoming valuable analytical tools for use in biomedical applications. Indeed, their unique properties offer the opportunity to design luminescent probes for imaging and sensing with unprecedented performance. In this context, we have identified operating principles to transduce supramolecular association of complementary receptor-ligand binding pairs into enhancement or suppression in the luminescence of sensitive quantum dots. Thus, complementary receptor-ligand binding pairs can be identified with luminescence measurements relying on our design logic. In fact, we have demonstrated with a representative example that our protocol can be adapted to signal receptor-ligand binding. | 2010-05-06 |
| 20100112561 | FLUORESCENT NUCLEOSIDE ANALOGUES - Briefly described, embodiments of the present disclosure include novel fluorescent nucleoside analogs (fNAs) including a fluorescent nucleobase, selected from a purine and a pyrimidine base or analog thereof, and a modified sugar moiety that differs in structure from a sugar moiety of a naturally occurring nucleoside. In embodiments, the fNAs of the present disclosure are analogues of NA prodrugs used to treat viral disorders. Embodiments of the present disclosure also include methods of making the novel fNAs of the present disclosure. | 2010-05-06 |
| 20100112562 | Mutation Implicated in Abnormality of Cardiac Sodium Channel Function - A novel mutation in the SCN5A gene is associated with loss of cardiac sodium channel function. Analysis of the novel mutation provides an early diagnosis of subjects with cardiac diseases or disorders caused by loss of cardiac sodium channel function, particularly Brugada syndrome. Diagnostic methods include analyzing the sequences of the SCN5A gene or protein of an individual to be tested and comparing them with the sequences of the native, nonvariant SCN5A gene or protein. Pre-symptomatic diagnosis of these syndromes will enable practitioners to treat these disorders using existing medical therapy, e.g., using sodium channel blockers or through electrical stimulation. | 2010-05-06 |
| 20100112563 | MULTIPLEX ANALYSIS OF NUCLEIC ACIDS - A method for identifying target nucleic acids includes the steps of contacting a sample containing a plurality of target nucleic acids with at least one series of nucleotide primers under conditions that allow binding of said primers to at least one of said target nucleic acids and labeling of said bound primers with a detectable signal, wherein one member within each series has a lower level of specificity than other members of the series; and measuring said detectable signal of each labeled primer to determine the identity of said target nucleic acids. | 2010-05-06 |
| 20100112564 | Methods for detecting therapeutic effects of anti-cancer drugs - precancerous lesions, and subject having precancerous lesions and being treated with an anti-cancer agent; (2) isolating total microbial genomic DNA from the fecal samples to provide total microbial genomic DNA; (3) comparing the total microbial genomic DNA using fingerprint spectrum analysis; (4) identifying key fingerprint bands correlated with the effect of the anti-cancer agent; (5) identifying key microorganisms associated with the key fingerprint bands; (6) designing microbial sequence-specific primers and probes; and (7) determining the quantitative differences of the key microorganisms in fecal samples to identify an indicator microorganism for monitoring the effect of the anti-cancer agent. | 2010-05-06 |
| 20100112565 | Methods, kits, and reaction mixtures for high resolution melt genotyping - Various methods are described that provide for high resolution melt (HRM) genotyping. Some embodiments comprise providing a locus specific primer, and two allele specific primers each comprising at least one single nucleotide polymorphism (SNP) allele-hybridizable sequence, wherein at least one of the allele specific primers also comprises at least one nucleotide alteration. In some embodiments, a nucleic acid is provided comprising a SNP base located within 1-20 bases of its 3′ end. Some embodiments comprise hybridizing the locus specific primer and at least one of the allele specific primers to the nucleic acid, amplifying the hybridized nucleic acid using pyrophosphorolysis activated polymerization (PAP) PCR, and determining the melting temperature (Tm) of the resulting amplicons, for example, using HRM. In some embodiments, reaction mixtures and kits for HRM genotyping are provided. The reaction mixtures and kits can each comprise a locus specific primer, one or more allele specific primers each comprising at least one SNP allele-hybridizable sequence, and a PAP PCR enzyme, wherein at least one of the allele specific primers also comprises a nucleotide alteration, for example, a tail. | 2010-05-06 |
| 20100112566 | VIPR1S as Modifiers of the E2F/RB Pathway and Methods of Use - Human VIPR1 genes are identified as modulators of the E2F/RB pathway, and thus are therapeutic targets for disorders associated with defective E2F/RB function. Methods for identifying modulators of E2F/RB, comprising screening for agents that modulate the activity of VIPR1 are provided. | 2010-05-06 |
| 20100112567 | RANDOM ACCESS SYSTEM AND METHOD FOR POLYMERASE CHAIN REACTION TESTING - A random access, high-throughput system and method for preparing a biological sample for polymerase chain reaction (PCR) testing are disclosed. The system includes a nucleic acid isolation/purification apparatus and a PCR apparatus. The nucleic acid isolation/purification apparatus magnetically captures nucleic acid (NA) solids from the biological sample and then suspends the NA in elution buffer solution. The PCR testing apparatus provides multiple cycles of the denaturing, annealing, and elongating thermal cycles. More particularly, the PCR testing apparatus includes a multi-vessel thermal cycler array that has a plurality of single-vessel thermal cyclers that is each individually-thermally-controllable so that adjacent single-vessel thermal cyclers can be heated or cooled to different temperatures corresponding to the different thermal cycles of the respective PCR testing process. | 2010-05-06 |
| 20100112568 | METHODS AND KITS FOR DIAGNOSIS OF MULTIPLE SCLEROSIS IN PROBABLE MULTIPLE SCLEROSIS SUBJECTS - Provided are methods and kits for determining the probability of a subject diagnosed with probable multiple sclerosis to develop definite diagnosis of multiple sclerosis by determining the expression level of polynucleotides which are differentially expressed between subjects diagnosed with probable multiple sclerosis and which further develop definite multiple sclerosis and unaffected subjects. Also provided are methods and kits for selecting a treatment regimen of a subject diagnosed with probable multiple sclerosis. | 2010-05-06 |
| 20100112569 | MICROFLUIDIC DEVICES AND METHODS OF GENERATING AND USING SAME - A microfluidic device comprising a substrate having formed therein microfluidic paths, at least a portion of the microfluidic paths having attached thereto a plurality of monolayers, wherein at least a portion of the monolayers comprises a photoactivatable group capable of generating a reactive group upon exposure to a light source, the reactive group being for binding a screenable moiety. | 2010-05-06 |
| 20100112570 | Genetic Markers for Weight Management and Methods of Use Thereof - This application relates to methods and tests that allow for the establishment of personalized weight-loss programs for a subject based upon the subject's metabolic genotype in key metabolic genes. Kits and methods are disclosed for determining a subject's metabolic genotype, which may be used to select an appropriate therapeutic/dietary regimen or lifestyle recommendation based upon the likelihood of a subject's responsiveness to certain diets and activity levels. Such a personalized weight-loss program will have obvious benefits (e.g., yield better results in terms of weight loss and weight maintenance) over traditional weight-loss programs that do not take into account genetic information. | 2010-05-06 |
| 20100112571 | COMPOSITIONS AND METHODS FOR DETECTING MUTATIONS IN JAK2 NUCLEIC ACID - The invention disclosed herein is based on the identification of novel mutations in the JAK2 gene and JAK2 protein. The invention provides compositions and methods useful for diagnosing hematopoietic diseases including, for example, myeloproliferative diseases. The invention also provides compositions and methods useful for determining a prognosis of an individual diagnosed as having a hematopoietic disease. | 2010-05-06 |
| 20100112572 | COMPOSITIONS, METHODS, AND KITS FOR FABRICATING CODED MOLECULAR TAGS - The teachings herein generally relates to probes comprising fabricated coded molecular tags for detecting analytes. The teachings also relate to compositions, methods, and kits for fabricating coded molecular tags comprising a multiplicity or reporter groups in an ordered pattern. | 2010-05-06 |
| 20100112573 | Methods, Compositions, and Kits Comprising Linker Probes for Quantifying Polynucleotides - The present invention is directed to methods, reagents, kits, and compositions for identifying and quantifying target polynucleotide sequences. A linker probe comprising a 3′ target specific portion, a loop, and a stem is hybridized to a target polynucleotide and extended to form a reaction product that includes a reverse primer portion and the stem nucleotides. A detector probe, a specific forward primer, and a reverse primer can be employed in an amplification reaction wherein the detector probe can detect the amplified target polynucleotide based on the stem nucleotides introduced by the linker probe. In some embodiments a plurality of short miRNAs are queried with a plurality of linker probes, wherein the linker probes all comprise a universal reverse primer portion a different 3′ target specific portion and different stems. The plurality of queried miRNAs can then be decoded in a plurality of amplification reactions. | 2010-05-06 |
| 20100112574 | Method for the Simultaneous Determination of Blood Group and Platelet Antigen Genotypes - RBC and platelet (Plt) alloimmunization requires antigen-matched blood to avoid adverse transfusion reactions. Some blood collection facilities use unregulated Abs to reduce the cost of mass screening, and later confirm the phenotype with government approved reagents. Alternatively, RBC and Plt antigens can be screened by virtue of their associated single nucleotide polymorphisms (SNPs). We developed a multiplex PCR-oligonucleotide extension assay using the GenomeLab SNPStream platform to genotype blood for a plurality of blood group antigen-associated SNPs, including but not limited to: RhD (2), RhC/c, RhE/e, S/s, K/k, Kp | 2010-05-06 |
| 20100112575 | Noninvasive Diagnosis of Fetal Aneuploidy by Sequencing - Disclosed is a method to achieve digital quantification of DNA (i.e., counting differences between identical sequences) using direct shotgun sequencing followed by mapping to the chromosome of origin and enumeration of fragments per chromosome. The preferred method uses massively parallel sequencing, which can produce tens of millions of short sequence tags in a single run and enabling a sampling that can be statistically evaluated. By counting the number of sequence tags mapped to a predefined window in each chromosome, the over- or under-representation of any chromosome in maternal plasma DNA contributed by an aneuploid fetus can be detected. This method does not require the differentiation of fetal versus maternal DNA. The median count of autosomal values is used as a normalization constant to account for differences in total number of sequence tags is used for comparison between samples and between chromosomes. | 2010-05-06 |
| 20100112576 | FOCUSING CHAMBER - Aspects of the invention relate to devices and methods of use thereof for concentrating, positioning and/or manipulating agents within a fluid, including but not limited to genomic DNA. | 2010-05-06 |
| 20100112577 | APPARATUS AND METHODS FOR EFFICIENT PROCESSING OF BIOLOGICAL SAMPLES ON SLIDES - Methods for treating biological samples on microscope slides are set forth. One aspect of the invention is the use of predried reagents in wells on trays onto which the slides are placed, especially the use of predried reagents which dissolve sequentially. Yet another aspect of the invention is the use of external controls placed directly on a microscope slide in conjunction with a biological sample to be assayed. The external controls can be conveniently placed on a membrane which can be affixed to the slide. A further aspect of the invention is a specially designed tray to allow whole chromosome painting of all chromosomes of a cell sample on a single slide. The invention is also drawn to a coverslip with concave wells which act as reaction chambers when placed against a slide and filled with buffer. Preferably a reagent is predried in the well. A further aspect of the invention is a method of reacting samples on slides by placing them into a reaction chamber together with a coverslip which has a predried reagent on it. | 2010-05-06 |
| 20100112578 | Test chip, detection apparatus, and method for detecting analyte - A test chip for detecting an analyte modified with a modulator releasing electrons upon photoexcitation, comprising: semiconductor electrode part including a metal layer formed on a semiconductor layer; a probe immobilized on the metal layer, the probe trapping the analyte; and a counter electrode part including a conductive layer. A detection apparatus and a method for detecting an analyte are also disclosed. | 2010-05-06 |
| 20100112579 | METHOD AND DEVICE FOR THE DETECTION OF GENETIC MATERIAL BY POLYMERASE CHAIN REACTION - The present invention relates to a method and a portable device to detect a genetic material in a biological sample using the technique known as PCR (Polymerase Chain Reaction). The device comprises a reaction chamber which incorporates means of heating arranged to heat said chamber. The detection method is characterized in that the main phases are performed in the reaction chamber. The miniaturized system has the object of increasing efficiency, simplicity of use and the portability of the PCR in comparison with laboratory scale analysis. | 2010-05-06 |
| 20100112580 | MEANS AND METHODS FOR HAPLOTYPING MHC-DRB LOCI IN MAMMALS AND USES THEREOF - The invention relates to the typing of MHC-DRB loci in mammals. In particular, the invention provides a typing procedure for the mammalian DRB region that allows an easy, economical, high resolution, fast and accurate haplotyping protocol. The invention further provides the use of said typing procedure in genetic applications, and provides a kit for typing of MHC-DRB loci. | 2010-05-06 |
| 20100112581 | METHODS FOR NORMALIZING AND FOR IDENTIFYING SMALL NUCLEIC ACIDS - The present teachings are generally directed to methods for normalizing at least one species of small nucleic acid that is present in a population of small nucleic acid species, wherein the relative concentration of at least one small nucleic acid species is substantially greater than the relative concentration of at least one other small nucleic acid species in the population. At least one small nucleic acid species is normalized using a multiplicity of primers comprising degenerate sequences. In some embodiments, a small nucleic acid species is identified by inserting at least part of an extension product from a normalized population into a vector and subsequently sequencing the insert. In some embodiments, a small nucleic acid species is identified by determining the sequence of at least part of an extension product. | 2010-05-06 |
| 20100112582 | GENE ENCODING LABYRINTHIN, A MARKER FOR CANCER - A cDNA molecule that encodes a protein designated Labyrinthin (Lab) isolated and its nucleotide sequence is determined. The protein, or peptides derived from the protein, are markers useful to define novel classes of cancers. Diagnostic assays for these cancers use antibodies to Lab or nucleotide probes that hybridize with the lab gene or a fragment therefrom. Vaccines useful either to prevent recurrence of cancers in subjects who test positive for Lab (or lab), or to prevent initial occurrence of cancer, use proteins or peptides derived from Lab. Expression of Lab via immunogenic assays is used to monitor effects of cancer treatments. Antisense molecules against lab are used in treatments. Sense molecules of lab are used to restore lost lab function in diseased normal cells, for example, gland cells. | 2010-05-06 |
| 20100112583 | BLOOD DIAGNOSIS METHOD FOR DIALYSIS PATIENT AND DIALYSIS MACHINE - Provided is a blood diagnosis method and a dialysis machine, using a diagnostic marker which is versatile and which can contribute to the improvements in dialysis treatment and the evaluation of clinical effects,
| 2010-05-06 |
| 20100112584 | CYANINE COMPOUNDS AND THEIR USE IN STAINING BIOLOGICAL SAMPLES - Cyanine compounds having the general formula I for staining biological samples, wherein R | 2010-05-06 |
| 20100112585 | Method for Enriching Methylated CpG Sequences - Compositions and methods are provided for facilitating the enrichment of single-stranded DNA containing methylated CpG in a mixture containing methylated and unmethylated DNA. The compositions relate to methylation-binding protein domains that selectively bind to methylated single strand DNA. In embodiments of the invention, the methylated DNA is eluted in 0.4M-0.6M NaCl while the unmethylated single strand DNA is eluted in less than 0.4M salt. The ability to readily enrich for methylated DNA permits high throughput sequencing of the methylated DNA and identification of abnormal methylation patterns associated with disease. | 2010-05-06 |
| 20100112586 | DIAGNOSIS OF FETAL ABNORMALITIES BY COMPARATIVE GENOMIC HYBRIDIZATION ANALYSIS - The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves performing comparative genomic hybridization (CGH) analysis when fetal cells are present in a mixed population of cells. The present invention involves detecting the presence of fetal cells in a mixed maternal sample by detecting the presence of non-maternal alleles in said sample. Furthermore, the present invention also involves correlating the presence of fetal cells in a mixed sample with CGH analysis results to detect a fetal abnormality or declare a test non-informative. | 2010-05-06 |
| 20100112587 | TRANSCRIPTOMIC BIOMARKERS FOR INDIVIDUAL RISK ASSESSMENT IN NEW ONSET HEART FAILURE - A novel transcriptomic biomarker for prognosis in heart failure has a direct clinical application in prediction of prognosis in new onset heart failure, heart disease, heart disorders and associated heart conditions. This approach should improve individualization of cardiac care and help identify patients at highest risk for circulatory collapse within the first years of presentation with heart failure. | 2010-05-06 |
| 20100112588 | METHODS FOR SANGER SEQUENCING USING PARTICLE ASSOCIATED CLONAL AMPLICONS AND HIGHLY PARALLEL ELECTROPHORETIC SIZE-BASED SEPARATION - Methods for highly parallel Sanger sequencing are discussed. In particular, provided herein are methods using particles to clonally amplify templates and to introduce the amplified nucleic acids into many parallel channels with a single template per channel. Once in the channels, the nucleic acids are separated by size using electrophoresis to produce long read length sequencing information. Methods involving optical detection of the size-separated nucleic acids and analysis of the resulting electropherograms to yield the sequences are disclosed. | 2010-05-06 |
| 20100112589 | ALLELE-ALLELE INTERACTIONS OF MTHFR GENE VARIANTS, AND USES THEREOF IN PREDICTING DISEASE RISK - The invention provides methods of predicting risk of developing a hyper-homocysteine-associated disease in a subject, based on genotyping of the methylenetetrahydrofolate reductase (MTHFR) gene, wherein the risk varies depending on whether the 677T polymorphism and the 1298C polymorphism are present in a cis configuration within a MTHFR gene or not. A preferred hyperhomocysteine-associated disease is myocardial infarction. Kits for predicting risk of developing a hyperhomocysteine-associated disease are also provided. | 2010-05-06 |
| 20100112590 | Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment - Embodiments of this invention provide methods, systems, and apparatus for determining whether a fetal chromosomal aneuploidy exists from a biological sample obtained from a pregnant female. Nucleic acid molecules of the biological sample are sequenced, such that a fraction of the genome is sequenced. Respective amounts of a clinically-relevant chromosome and of background chromosomes are determined from results of the sequencing. The determination of the relative amounts may count sequences of only certain length. A parameter derived from these amounts (e.g. a ratio) is compared to one or more cutoff values, thereby determining a classification of whether a fetal chromosomal aneuploidy exists. Prior to sequencing, the biological sample may be enriched for DNA fragments of a particular sizes. | 2010-05-06 |
| 20100112591 | Tumor Suppressor Gene - A full-length cDNA encoding novel proteins involved in the control of cell proliferation (human Gros1-L and S) was successfully isolated from the human testis cDNA libraries. A full-length cDNA encoding the mouse homologues of the human Gros1 (mouse Gros1-L and S) was also isolated. The colony forming activity of cells exogenously expressing Gros1-L was significantly reduced, while that of cells expressing Gros1 antisense RNA was significantly increased. | 2010-05-06 |
| 20100112592 | METHODS FOR IDENTIFYING AN INCREASED LIKELIHOOD OF RECURRENCE OF BREAST CANCER - Methods of identifying a mammal having an increased likelihood of recurrence of breast cancer includes identifying in a breast tissue sample of the mammal expression of at least two genes selected from the group consisting of Hs.125867 (EVL), Hs.591847 (NAT1), Hs.208124 (ESR1), Hs.26225 (GABRP), Hs.408614 (ST8SIA1), Hs.480819 (TBC1D9), Hs.504115 (TRIM29), Hs.523468 (SCUBE2), Hs.532082 (IL6ST), Hs.592121 (RABEP1), Hs.79136 (SLC39A6), Hs.82128 (TPBG), Hs.95243 (TCEAL1), Hs.95612 (DSC2), Hs.654961 (FUT8), Hs.1594 (CENPA), Hs.184339 (MELK), Hs.26010 (PFKP), Hs.592049 (PLK1), Hs.370834 (ATAD2), Hs.437638 (XBP1), Hs.444118 (MCM6), Hs.469649 (BUB1), Hs.470477 (PTP4A2), Hs.473583 (YBX1), Hs.480938 (LRBA), Hs.524134 (GATA3), Hs.531668 (CX3CL1), Hs.532824 (MAPRE2), Hs.591314 (GMPS), Hs.83758 (CKS2) and Hs.99962 (SLC43A3) and subsets of the genes. | 2010-05-06 |
| 20100112593 | Method of Predicting the Clinical Response to Chemotherapeutic Treatment with Alkylating Agents - The present invention provides methods relating to chemotherapeutic treatment of a cell proliferative disorder. In particular, a method is provided for predicting the clinical response to certain types of chemotherapeutic agents. Alkylating agents, used for the treatment of certain types of tumors including tumors of the nervous system and lymph system, are efficacious agents when the damage they do to tumor cell DNA is not repaired by cellular DNA repair mechanisms. The present invention provides a method for determining the activity of a gene encoding a DNA repair enzyme, thus providing a prediction of the clinical response to alkylating agents. | 2010-05-06 |
| 20100112594 | METHOD FOR ENUMERATING MAMMALIAN CELL MICRONUCLEI WITH AN EMPHASIS ON DIFFERENTIALLY STAINING MICRONUCLEI AND THE CHROMATIN OF DEAD AND DYING CELLS - The present invention relates a method for the enumeration of mammalian cell micronuclei, while distinguishing micronuclei from the chromatin of dead and dying cells. The method utilizes differential staining of chromatin from dead and dying cells, to distinguish the chromatin from micronuclei and nuclei that can be detected based upon fluorescent emission and light scatter following exposure to an excitatory light source. Counting of micronuclei events relative to the number of nuclei can be used to assess the DNA-damaging potential of a chemical agent, the DNA-damaging potential of a physical agent, the effects of an agent which can modify endogenously-induced DNA damage, and the effects of an agent which can modify exogenously-induced DNA damage. Kits for practicing the invention are also disclosed. | 2010-05-06 |
| 20100112595 | Bisulfite Conversion Reagent - Disclosed, among other things, are packaged bisulfite solutions comprising bisulfite reagent in an oxygen-impermeable container and methods. | 2010-05-06 |
| 20100112596 | KIT FOR DECIDING DEGREE OF MALIGNANCY IN PROSTATE CANCER AND METHOD OF USING THE SAME - The present invention relates to kits and methods for determining (diagnosing) prostate cancer malignancy and to predict patient prognoses. In addition to the Gleason's classification and the TMN classification, the invention kit and methods provide improved procedures with molecular markers. These new diagnostic methods provide methods capable of determining prostate cancer malignancy more accurately and easily through combination with the Gleason's classification via biopsies at an early stage before surgical operation; even when specimens taken through a fine needle examination are used instead of specimens extracted during a surgical operation. | 2010-05-06 |
| 20100112597 | Methods for Quantifying Protein Leakage From Protein Based Affinity Chromatography Resins - The present invention provides methods of quantifying protein leakage from a protein based affinity chromatography media (e.g., protein A, protein G and protein L based affinity chromatography media), where such a protein is used for isolating and/or removing a molecule which binds the protein (e.g., an immunoglobulin). | 2010-05-06 |
| 20100112598 | Novel Assay for Inositol Phosphorylceramide Synthase Activity - Disclosed is a simple and reproducible method for assaying inositol phosphorylceramide synthase activity that employs a fluorescence resonance energy transfer pair for measuring enzyme activity. The invention also includes a novel method for identifying IPC synthase inhibitors. | 2010-05-06 |
| 20100112599 | METHOD FOR THE COUPLED ENZYME IMMUNOCHEMICAL ASSAY OF ANALYTES BY MEANS OF ENDOGENOUS CALIBRATORS - The invention relates to a method for assaying a plurality of analytes such as e.g. metabolites and antigens in biological and other liquid samples by means of analytical elements, especially lateral-flow test strips, flow-through membrane systems (flow-through tests), wells/cavities of microtitre plates or test tubes, the method according to the invention being based on coupled enzyme and affinity reactions and being carried out by means of endogenous calibrators, i.e. endogenously produced substances, by means of which dilutions of sample matrices can be corrected (e.g. creatinine, glucose, glucose-6-phosphate, lactate, glutamate, aspartate, cholesterol, pyruvate, urea and triglycerides). | 2010-05-06 |
| 20100112600 | Methods and compositions for modulating synapse formation - The invention provides methods of modulating synapse formation. Methods for identifying agents to modulate synapse formation are also disclosed. | 2010-05-06 |
| 20100112601 | NOVEL MONOCLONAL ANTIBODY AND USE OF THE SAME - The present invention provides an anti-PAC1 monoclonal antibody capable of recognizing a PAC1 having a native structure, a PAC1 activity regulator (in particular, activity inhibitor) containing the antibody, a prophylactic/therapeutic agent for a disease associated with accentuation of a bioactivity of PAC1, containing the antibody, a diagnostic reagent for a disease associated with an abnormality of PAC1 activity, containing the antibody, and a screening method for a substance that regulates the expression of PAC1, using the antibody and a PAC1-expressing cell. | 2010-05-06 |
| 20100112602 | Protein-Protein Interaction Biosensors and Methods of Use Thereof - The invention provides methods and reagents for identifying an agent, such as by screening a library of agents, that modulates the interaction of two or more polypeptides, the method comprising: introducing into a cell at least a first polypeptide, each comprising a binding domain, wherein the first polypeptide comprises a localization domain of the second polypeptide; and detecting the cellular location of the first polypeptide, the second polypeptide or a combination thereof, wherein a change in the cellular location of the first polypeptide, the second polypeptide or a combination thereof indicates that the agent modulates the interaction of the two or more polypeptides. The invention also provides methods and reagents for identifying the binding domains of one or more polypeptides. | 2010-05-06 |
| 20100112603 | METHOD FOR PREDICTING THE RESPONSE TO A TREATMENT - The invention is related to a method of predicting the response to a treatment with a HER inhibitor in a patient comprising the steps of assessing a biomarker or a combination of biomarkers selected from the group consisting of amphiregulin, an epidermal growth factor, a transforming growth factor alpha, and a HER2 biomarker in a biological sample from the patient and predicting the response to the treatment with the HER inhibitor in the patient by evaluating the results of the first step. Further uses and methods wherein these markers are used are disclosed. | 2010-05-06 |
| 20100112604 | HOME FOOD TEST KIT AND METHOD OF USE - A home test kit for detecting the presence or absence of melamine (1,3,5-triazine-2,4,6-triamine) has a sample extract container in which a volume of extract solution is present; a test strip, the test strip being a lateral flow device for detecting melamine (1,3,5-triazine-2,4,6-triamine) in a food or beverage sample; and wherein a food or beverage sample is placed in the sample extract container to form an aqueous sample extract solution and the test strip is inserted directly into the aqueous sample for an instructed time then the strip is removed and observed for a color change. The method of using the kit involves a visual observation without requiring any other equipment. | 2010-05-06 |
| 20100112605 | Biomarker for the Medicine and the Biology of the Reproduction - The present invention relates to a new biomarker for the medicine and the biology of reproduction, in particular for in vitro fertilization (IVF) outcome. It relates to methods for predicting IVF outcome and for selecting the subject for IVF. | 2010-05-06 |
| 20100112606 | MEASUREMENT AND ANALYSIS OF LEUKOTRIENES - The present invention provides a new analytical method for measuring leukotrienes in a clinical sample using liquid chromatography and tandem mass spectrometry (LCMSMS). The method provides a simple, rapid and low-cost assay for the measurement of leukotriene levels in a clinical sample with high accuracy and precision over the physiological range. The present invention further provides a method to determine the susceptibility of a subject to treatment with a leukotriene modifier, as wells as methods for diagnosis of a chronic obstructive disease of the airways and for predicting the risk of exacerbation of the same. | 2010-05-06 |
| 20100112607 | METHODS FOR DETERMINING ACTIVE INGREDIENTS IN PRO-DRUG PEG PROTEIN CONJUGATES WITH RELEASABLE PEG REAGENTS (IN VITRO DE-PEGYLATION) - The invention relates to the development of in vitro assay systems that force the release of a water-soluble polymer, such as polyethylene glycol (PEG) and polysialic acid (PSA), from proteins modified with a reversibly-linked water-soluble polymer. The invention includes methods for analyzing the release of the water-soluble polymer and measuring regained protein activity. The invention further includes methods appropriate for the quality control of proteins modified with releasable water-soluble polymers, including polymers like PEG and PSA. | 2010-05-06 |
| 20100112608 | METHOD OF DIAGNOSING LAWSONIA INTRACELLULARIS - The present invention relates to the field of animal health and in particular to | 2010-05-06 |
| 20100112609 | Determining and Reducing Immunoresistance to a Botulinum Toxin Therapy Using Botulinum Toxin B Peptides - The present invention provides BoNT/B peptides, BoNT/B peptide compositions, tolerogizing compositions, immune response inducing compositions, as well as methods of determining immunoresistance to botulinum toxin therapy in an individual, methods of treating immunoresistance to botulinum toxin therapy in an individual, methods of reducing anti-botulinum toxin antibodies in an individual and methods of inducing a BoNT/B immune response an individual. | 2010-05-06 |
| 20100112610 | Determining and Reducing Immunoresistance to a Botulinum Toxin Therapy Using Botulinum Toxin B Peptides - The present invention provides BoNT/B peptides, BoNT/B peptide compositions, tolerogizing compositions, immune response inducing compositions, as well as methods of determining immunoresistance to botulinum toxin therapy in an individual, methods of treating immunoresistance to botulinum toxin therapy in an individual, methods of reducing anti-botulinum toxin antibodies in an individual and methods of inducing a BoNT/B immune response an individual. | 2010-05-06 |
| 20100112611 | PROCEDURE FOR DETECTING MICROBIAL CONTAMINATION BY BIOLUMINESCENCE IN ASSOCIATIVE ACRYLIC THICKENERS AND PRODUCTS CONTAINING THEM - A procedure for detecting microorganisms by bioluminescence in an aqueous formulation containing an ASE or HASE-type polymer, which implements at least one step of dilution of the aqueous formulation. This dilution step, and notably the regulation of the dilution factor, allows the bioluminescence technique, up to now ineffective on this type of products, to be implemented. It can henceforth be used on these ASE or HASE-type polymers, but also on products containing them, such as a paper coating, paint, lacquer, varnish or stain. | 2010-05-06 |
| 20100112612 | METHOD FOR DETERMINING AN ANALYTE USING AN ANALYTICAL TEST STRIP WITH A MINIMAL FILL-ERROR VIEWING WINDOW - A method for determining an analyte (such a glucose) in a bodily fluid sample includes introducing a bodily fluid sample (e.g., a whole blood sample) into a sample-receiving chamber of an analytical test strip. The method also includes verifying that the bodily fluid sample has filled at least a working portion of the sample-receiving chamber by user visual observation of the working portion through a first portion of a top layer of the analytical test strip, while an opaque second portion of the top layer precludes user visual observation of a non-working portion of the sample-receiving chamber. Thereafter, in the method, the concentration of analyte in the bodily fluid sample is determined only if during the verifying step the user has verified that the bodily fluid sample has filled the working portion. | 2010-05-06 |
| 20100112613 | Biosensor Membranes Composed of Polymers Containing Heterocyclic Nitrogens - Novel membranes comprising various polymers containing heterocyclic nitrogen groups are described. These membranes are usefully employed in electrochemical sensors, such as amperometric biosensors. More particularly, these membranes effectively regulate a flux of analyte to a measurement electrode in an electrochemical sensor, thereby improving the functioning of the electrochemical sensor over a significant range of analyte concentrations. Electrochemical sensors equipped with such membranes are also described. | 2010-05-06 |
| 20100112614 | Coupled Antenna Impedance Spectroscopy - It has been found advantageous to deploy coiled antennas as transmitters and receivers for acquiring the dielectric spectrum of materials. This method of impendence spectroscopy has been used to determine the concentration of glucose and other small polar molecules in vitro, as well as in vivo by placement on the antennas so that transmission is through the tissue, as for example on opposite sides of an organ or body part. The optimum selection of antenna coils permits deeper penetration into tissue for glucose detection, improves the SNR as well as expands the spectral range for greater accuracy and precision, to enable continuous non-invasive monitoring for either improved patient or automated management of diabetes. | 2010-05-06 |
| 20100112615 | GLYCOSYLTRANSFERASE ACTIVITY - We describe the production of nucleotide sugars other than uridine diphosphate glucose (UDP-glucose), for example UDP-rhamnose, and the use of these nucleotide sugars in the modification of acceptor molecules. | 2010-05-06 |
| 20100112616 | NOVEL BETA-GALACTOSIDE-a2,6-SIALYLTRANSFERASE, A GENE ENCODING THEREOF, AND A METHOD FOR ENHANCING ENZYME ACTIVITY - The present invention provides an extremely useful and novel β-galactoside-α2,6-sialyltransferase having an optimum reaction pH in a neutral to alkaline range, and a nucleic acid encoding the sialyltransferase. The present invention further provides a vector carrying a nucleic acid encoding the sialyltransferase, and a host cell transformed with the vector, as well as a method for producing a recombinant β-galactoside-α2,6-sialyltransferase. | 2010-05-06 |
| 20100112617 | Evaluating RTK Target Drugs - Methods of evaluating receptor tyrosine kinase drug efficacy are demonstrated. The methods generally relate to evaluation methods using phospho-RTK over total RTK ratio (pRTK/tRTK). An algorithm is provided that allows the user to combine the pRTK/tRTK ratios from several kinase together with other kinds of measurements to obtain a PDX value that is indicative of drug efficacy. | 2010-05-06 |
| 20100112618 | Measurement of the Activity of a Kynurenine-Converting Enzyme and/or a Kynurenic-Acid, Anthranilic-Acid and/or 3-Hydroxykynurenine-Producing Enzyme - The present invention relates to a method of measuring the activity of a kynurenine-converting enzyme and/or a kynurenic-acid-, anthranilic-acid- and/or 3-hydroxykynurenine-producing enzyme, the method comprising the step of measuring the activity in the presence of an interfering sample, preferably selected from a CSF (cerebrospinal fluid) or serum, and detecting the conversion of kynurenine and/or kynurenic acid and/or anthranilic acid and/or 3-hydroxykynurenine. | 2010-05-06 |
