18th week of 2020 patent applcation highlights part 29 |
Patent application number | Title | Published |
20200131531 | BORNA VIRAL VECTOR AND USE THEREOF - Disclosed is a viral vector comprising (a) a cDNA of a recombinant viral RNA having a sequence of a Borna disease viral genome comprising a disrupted G gene of the Borna disease viral genome and an inserted G gene of an avian bornaviral genome, wherein the cDNA of the recombinant viral RNA has at least an N gene, an X gene, a P gene and an L gene of the Borna disease viral genome in the same order as in the Borna disease viral genome and has an inserted foreign gene; (b) DNAs encoding ribozymes; and (c) a promoter sequence, wherein (b) the DNAs encoding ribozymes are located upstream and downstream of (a) the cDNA of the recombinant viral RNA, and (a) the cDNA of the recombinant viral RNA and (b) the DNAs encoding ribozymes are located downstream of (c) the promoter sequence. The present invention can be used as a gene introduction technique that does not affect a host chromosome and can be suitable for the application in various fields, such as the treatment and prevention of brain and neurological diseases, visualization techniques of nerve cells in the field of neuroscience, etc. | 2020-04-30 |
20200131532 | GENE THERAPY FOR OCULAR DISORDERS - Compositions and methods are provided for treating ocular neuropathy in a subject. In one aspect, a recombinant adeno-associated viral vector is provided which includes a nucleic acid molecule comprising a sequence encoding NRF2. In another aspect, a recombinant adeno-associated viral vector is provided which includes a nucleic acid molecule comprising a sequence encoding SIRT1. In desired embodiments, the subject is human, cat, dog, sheep, or non-human primate. | 2020-04-30 |
20200131533 | Methods for Analysis of Viral Capsid Protein Composition - Methods of determining the stoichiometry of a viral capsid and/or determining the heterogeneity of protein components in a viral capsid are disclosed. | 2020-04-30 |
20200131534 | METHOD OF DETECTING AND/OR IDENTIFYING ADENO-ASSOCIATED VIRUS (AAV) SEQUENCES AND ISOLATING NOVEL SEQUENCES IDENTIFIED THEREBY - Adeno-associated virus rh.20 sequences, vectors containing same, and methods of use are provided. | 2020-04-30 |
20200131535 | VECTORS WITH MODIFIED INITIATION CODON FOR THE TRANSLATION OF AAV-REP78 USEFUL FOR PRODUCTION OF AAV - The present invention relates nucleic acid constructs for the production of recombinant parvoviral (e.g. adeno-associated viral) vectors in insect cells, to insect cells comprising such constructs and to methods wherein the cells are used to produce recombinant parvoviral virions. The insect cells preferably comprise a first nucleotide sequence encoding the parvoviral rep proteins whereby the initiation codon for translation of the parvoviral Rep78 protein is a suboptimal initiation codon that effects partial exon skipping upon expression in insect cells. The insect cell further comprises a second nucleotide sequence comprising at least one parvoviral (AA V) inverted terminal repeat (ITR) nucleotide sequence and a third nucleotide sequence comprising a sequences coding for the parvoviral capsid proteins. | 2020-04-30 |
20200131536 | METHOD FOR IDENTIFYING DNA BASE EDITING BY MEANS OF CYTOSINE DEAMINASE - Provided are: a composition for DNA double-strand breaks (DSBs), comprising (1) a cytosine deaminase and an inactivated target-specific endonuclease, (2) a guide RNA, and (3) a uracil-specific excision reagent (USER); a method for producing DNA double-strand breaks by means of a cytosine deaminase using the composition; a method for analyzing a DNA nucleic acid sequence to which base editing has been introduced by means of a cytosine deaminase; and a method for identifying (or measuring or detecting) base editing, base editing efficiency at an on-target site, an off-target site, and/or target specificity by means of a cytosine deaminase. | 2020-04-30 |
20200131537 | Targeted Gene Therapies for Pain and Other Neuro-Related Disorders - Provided herein are nucleic acids for expressing modified ligand-gated ion channel proteins in excitable cells or secretory cells, such as nerves and neurons and optionally including viral sequences, such as Adeno-associated virus sequences, for delivery to excitable cells or secretory cells of a patient. Also provided herein are methods of modulating cell membrane potentials in an excitable cell or secretory cell, and for treatment of a disease or disorder associated with the nervous system in a patient, such as chronic pain or itch. | 2020-04-30 |
20200131538 | MICROORGANISM WITH STABILIZED COPY NUMBER OF FUNCTIONAL DNA SEQUENCE AND ASSOCIATED METHODS - The invention provides processes for identifying and tracking genomic duplications that can occur during classical strain development or during the metabolic evolution of microbial strains originally constructed for the production of a biochemical through specific genetic manipulations, processes that stabilize the copy number of desirable genomic duplications using appropriate selectable markers, and non-naturally occurring microorganisms with stabilized copy numbers of a functional DNA sequence. | 2020-04-30 |
20200131539 | CRISPR/CAS 9-MEDIATED INTEGRATION OF POLYNUCLEOTIDES BY SEQUENTIAL HOMOLOGOUS RECOMBINATION OF AAV DONOR VECTORS - The present invention relates to a system and method for efficiently modifying the genome of cells to treat diseases via sequential homologous recombination using CRISPR/Cas-mediated genome editing with donor DNA delivered by two or more adeno-associated virus (AAV) vectors. | 2020-04-30 |
20200131540 | RECOMBINATION ACTIVATING GENE (RAG) INDUCED V(D)J GENE TARGETING - The present invention relates to methods for targeted insertion of at least one nucleic acid sequence/s of interest into a target genomic locus of a mammalian cell. More specifically, the methods of the invention are based on using nucleic acid cassettes comprising the nucleic acid sequence/s of interest and at least one recognition signal sequence (RSS), for insertion of the nucleic acid sequence of interest into the target genomic locus that is mediated by RAG-catalyzed recombination. The invention further provides cassettes, vectors and vehicles and cells comprising said cassettes, compositions and uses thereof in immunotherapy. | 2020-04-30 |
20200131541 | Biological agent for enrichment of anaerobic digestion reactors, method of preparing such biological agent and bio-augmentation process with said agent - Biological agent for bio-augmentation of an anaerobic digestion reactor, named first anaerobic digestion reactor, comprising a mixture of microorganisms including at least 10% of relative abundance in said mixture, of a unique | 2020-04-30 |
20200131542 | METHOD FOR THE PREPARATION OF 2,4-DIHYDROXYBUTYRATE - A method for the preparation of 2,4-dihydroxybutyric acid from homoserine includes a first step of conversion of the primary amino group of homoserine to a carbonyl group to obtain 2-oxo-4-hydroxybutyrate, and a second step of reduction of the obtained 2-oxo-4-hydroxybutyrate (OHB) to 2,4-dihydroxybutyrate. | 2020-04-30 |
20200131543 | A METHOD FOR THE PRODUCTION OF CARBOXYLIC ACIDS UNDER UNSTERILE CONDITIONS - The aim of the invention is to provide a method for biotechnological production of carboxylic acids, in which the acid-forming micro-organisms are cultured in an unsterile manner in a submerged phase containing waste water containing all carbon and nutrient medium components necessary for the production of the carboxylic acid, which method avoids the disadvantages of known methods and enables high product concentrations and productivity while at the same time the resources of water and power are being conserved. This aim is achieved, according to the invention, in that micro-organisms are used that are cultured under unsterile conditions in a culture medium containing waste water with the addition of carbon-rich compounds. | 2020-04-30 |
20200131544 | VARIANT THIOESTERASES AND METHODS OF USE - The present invention relates to variant thioesterases and their use in plants, e.g., to increase enzymatic activity and to promote increased production of mid-chain length fatty acids (e.g., 8 to 14 carbons) and at desired ratios. Further disclosed herein are methods of manufacturing renewable chemicals through the manufacture of novel triglyceride oils followed by chemical modification of the oils. Oils containing fatty acid chain lengths of C8, C10, C12 or C14 are also disclosed and are useful as feedstocks in the methods described herein. | 2020-04-30 |
20200131545 | NOVEL ASPARTOKINASE VARIANT AND METHOD FOR PRODUCING L-AMINO ACID USING THE SAME - An aspartokinase variant, a microorganism comprising the variant, and a method for producing an aspartate-derived L-amino acid or a homoserine derivative thereof using the microorganism. | 2020-04-30 |
20200131546 | METHOD FOR PRODUCING THEANINE - According to the present invention, theanine can efficiently be produced without exogenously adding ethylamine and without accumulation or leftover of ethylamine as a byproduct, by using a microorganism having enhanced activity to produce ethylamine with acetaldehyde and alanine as substrates and having enhanced activity of γ-glutamylmethylamide synthetase or glutaminase. | 2020-04-30 |
20200131547 | ENZYMATIC PRODUCTION OF HEXOSES - Disclosed herein are methods of producing hexoses from saccharides by enzymatic processes. The methods utilize fructose 6-phosphate and at least one enzymatic step to convert it to a hexose. | 2020-04-30 |
20200131548 | SYSTEM FOR PRODUCTION OF ADENOSINE TRIPHOSPHATE - The present invention relates to a system for production of ATP. This system is comprised of a support and one or more enzymes coupled to that support which are capable of collectively producing ATP from glucose or fructose metabolism. The present invention is additionally directed to a device, which includes the system, and to a method for carrying out a reaction involving the conversion of ATP to ADP using the system. | 2020-04-30 |
20200131549 | POLYNUCLEOTIDE MODIFICATION METHODS - The invention relates to a method for modifying a template double stranded polynucleotide, especially for characterization using nanopore sequencing. The method produces from the template a plurality of modified double stranded polynucleotides. These modified polynucleotides can then be characterized. | 2020-04-30 |
20200131550 | RNA POLYMERASE VARIANTS - The present disclosure provides, in some aspects, variant RNA polymerases, the use of which increases transcription efficiency while reducing the number of double-stranded RNA contaminates and run-on transcripts produced during an in vitro transcription reaction. | 2020-04-30 |
20200131551 | METHOD FOR PRODUCING ENZYMATIC REACTION BY USING ADENOSINE TO REPLACE ATP - The present invention discloses a production method of enzymatic reaction using adenosine instead of ATP. The method comprises the following steps: (1) adding ATP regeneration enzyme, AK enzyme and adenosine in proportion to carry out an enzymatic reaction in an enzymatic reaction system; (2) separating the ATP regeneration enzyme and AK enzyme by either directly separating ATP regeneration enzyme and AK enzyme immobilized in a reaction tank or separating free ATP regeneration enzyme and AK enzyme by an ultrafiltration membrane in a filter; and (3) separating and purifying the filtrate of step (2) to obtain a product. The disclosed method provides: greatly reduced industrial production costs; faster reaction rate; stable enzyme recovery system that is energy efficient and environmentally friendly; and capability of reusing the byproducts or collecting them for the production of ATP. | 2020-04-30 |
20200131552 | IVERMECTIN B1B PRODUCING STRAIN AND USE THEREOF - Provided are a | 2020-04-30 |
20200131553 | A CHLOROPLAST OR ACCUMULATED LIPID PARTICLE ENRICHED WITH AN OIL-BODY PROTEIN FUSION POLYPEPTIDE AND METHOD FOR PRODUCING THE SAME IN ALGAE - The present invention relates to recombinant protein production in algal cells. In particular, the present invention provides methods for making recombinant polypeptides in association with accumulated lipid particles or chloroplasts. The methods involve producing the recombinant polypeptide as a fusion polypeptide with an oil body protein and the growth of the algal cells under non-homeostatic conditions to form accumulated lipid particles within the algal cells, wherein the algal lipid particles contain the fusion polypeptide. | 2020-04-30 |
20200131554 | CELL CULTURE PROCESS FOR MAKING A GLYCOPROTEIN - The instant application provides a method for screening batches of soy hydrolysate for a desired amount of a component thereof, such as ornithine or putrescine, and selecting only those batches of soy hydrolysate that have a desired amount of such component. The present disclosure also sets forth methods for culturing cells in media supplemented with selected batches of soy to produce more consistent, high quality lots of a protein of interest. Further, the present disclosure provides a plurality of protein preparations that have each been produced by culturing cells in media supplemented with separate batches of soy hydrolysate containing a desired amount of ornithine or putrescine, whereby each batch of protein produced exhibits improved quality of the protein of interest or amount of quality protein produced. | 2020-04-30 |
20200131555 | INCORPORATION OF UNNATURAL NUCLEOTIDES AND METHODS THEREOF - Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA. | 2020-04-30 |
20200131556 | SPORE-BASED BIO-HYBRID MICROROBOTS AND THE AUTOMATED DETECTION SYSTEM FOR BACTERIAL TOXINS - Disclosed are materials, devices, methods and systems for the detection of target molecules in test samples using microrobots. The target molecules may be bacterial toxins. The microrobots may include biohybrid materials such as porous spore core, a middle layer coated on the spore core for the actuation and steering in a fluid and further conjugation with a functional probe, and a sensing probe anchored onto middle layer for attaching to the targeted molecules in a fluid to respond to fluorescent tracking. A system for detecting bacterial toxin, is disclosed and comprises an intelligent motion control system based on automated fluorescent recognition and detection methods, which can propel and guide the microrobots to realize the automated motion in a pre-designed path and perform the real-time monitoring when integrating with an inverted fluorescent microscope or a fluorescent emission multi-reader. | 2020-04-30 |
20200131557 | PHENOTYPIC CHARACTERIZATION OF CELLS - Phenotyping of cells involves loading a biological sample into a microfluidic device ( | 2020-04-30 |
20200131558 | PAPER-BASED ASSAY FOR ANTIMICROBIAL RESISTANCE - Antimicrobial resistance (AMR), the ability of a bacterial species to resist the action of an antimicrobial drug, has been on the rise due to the widespread use of antimicrobial agents, and one of the many ways AMR can spread is through contaminated water sources. To monitor these water sources, we have developed an inexpensive, fast assay using a paper-based analytical device (PAD) that can test for the presence of β-lactamase-mediated resistance as one major form of AMR that has reliably detected resistance in sewage water. | 2020-04-30 |
20200131559 | Salivary Urea Nitrogen Rapid Detection - Apparatus and methods for measuring a concentration of a target molecule from a biological sample are disclosed. For example, the apparatus comprises a porous pad, which is impregnated with a solution containing at least one agent and contains an unfilled capillary matrix, a housing for the porous pad, and a membrane that covers the porous pad. | 2020-04-30 |
20200131560 | BLOOD SAMPLE ASSAY METHOD - The invention provides an enzymatic method for measuring the concentration of one or more analytes in the plasma portion of a blood derived sample, containing a first and a second component, where said second component interferes with the measurement of said first component. The method includes: i) diluting the sample with a reagent mixture; ii) substantially removing blood cells; iii) using a reagent which serves to temporarily prevent reaction of the second component, to generate a blocked second component; iv) causing the selective reaction of a constituent of each analyte to directly or indirectly generate detectable reaction products, where one of the analytes is the first component; v) monitoring the detectable reaction product or products; vi) relating an amount of the detectable product or products and/or a rate of formation of the detectable product or products to the concentration of each analyte, where the concentration of at least the first component is related to a corresponding detectable reaction product by means of estimating an un-measurable (fictive) endpoint. Step iii) may be carried out at any stage up to and including step iv) but before steps v) or vi). The reagent of step iii) may be applied to the sample separately or may be included in a reagent mixture during steps i) or iv). A corresponding kit is also provided. | 2020-04-30 |
20200131561 | METHODS FOR TARGETED NUCLEIC ACID SEQUENCE ENRICHMENT WITH APPLICATIONS TO ERROR CORRECTED NUCLEIC ACID SEQUENCING - The present technology relates generally to methods and compositions for targeted nucleic acid sequence enrichment, as well as uses of such enrichment for error-corrected nucleic acid sequencing applications. In some embodiments, highly accurate, error corrected and massively parallel sequencing of nucleic acid material is possible using a combination of uniquely labeled strands in a double-stranded nucleic acid complex in such a way that each strand can be informatically related to its complementary strand, but also distinguished from it following sequencing of each strand or an amplified product derived therefrom. In various embodiments, this information can be used for the purpose of error correction of the determined sequence. | 2020-04-30 |
20200131562 | METHOD FOR INTEGRALLY DETECTING NONDESTRUCTIVE MEASUREMENT INFORMATION AND GENOME-RELATED INFORMATION OF ONE CELL - The present invention provides a method for integrally detecting nondestructive measurement information and genome-related information of single cells. | 2020-04-30 |
20200131563 | CONTROL NUCLEIC ACIDS, AND COMPOSITIONS, KITS, AND USES THEREOF - Provided are methods, as well as compositions, kits, and systems for preparing optimized control nucleic acids (polynucleotides) having reduce nucleic acid damage. Provided nucleic acid compositions provide reduced artifacts as compared to nucleic acid compositions prepared by conventional methods. Provided compositions are useful control in a variety of applications, including, but not limited to sequencing workflows to effectively monitor sensitivity, accuracy and/or precision of data. | 2020-04-30 |
20200131564 | HIGH-COVERAGE AND ULTRA-ACCURATE IMMUNE REPERTOIRE SEQUENCING USING MOLECULAR IDENTIFIERS - The present disclosure provides methods for the amplification and sequencing of the immune repertoire using barcoded oligonucleotides with molecular identifiers (MIDs). Further provided are methods for clustering-based data analysis of the sequencing reads to determine the immune repertoire. | 2020-04-30 |
20200131565 | AUTOMATED METHOD FOR DETECTING CERVICAL CANCERS AND HIGH GRADE HYPERPLASIAS - Automated methods for detecting cancer and related hyperplasias in biological samples. | 2020-04-30 |
20200131566 | METHODS, COMPOSITIONS AND SYSTEMS FOR CALIBRATING EPIGENETIC PARTITIONING ASSAYS - In an aspect, a method for evaluating the partitioning of nucleic acid molecules in a sample of polynucleotides based on epigenetic state, comprising: (a) adding a set of epigenetic-control nucleic acid molecules to the nucleic acid molecules in the sample of polynucleotides, whereby producing a spiked-in sample; (b) partitioning nucleic acid molecules of the spiked-in sample into plurality of partitioned sets; (c) enriching a subset of molecules from the plurality of partitioned sets to generate enriched molecules, wherein the enriched molecules comprises a group of epigenetic-control nucleic acid molecules and a group of nucleic acid molecules from the sample of polynucleotides; (d) sequencing the enriched molecules to produce sequencing reads; (e) analyzing the sequencing reads to generate one or more epigenetic partition scores of the epigenetic-control nucleic acid molecules; and (f) comparing the one or more epigenetic partition scores with one or more epigenetic partition cut-offs. | 2020-04-30 |
20200131567 | METHODS OF ATTACHING ADAPTERS TO SAMPLE NUCLEIC ACIDS - Methods of preparing double-stranded nucleic acids with single-stranded overhangs for amplification and sequencing are disclosed. Contacting a blunt-ended double-stranded nucleic acid molecules with Taq results in non-templated directed addition of a single nucleotide to the 3′ ends of the nucleic acid with A added most frequently followed by G followed by C and T. G tailing is sufficiently frequent that the efficiency of ligation of nucleic acid molecules to adapters can be significantly increased by including adapters tailed with T and C. The ligation efficiency can be increased even further with blunted-ended adapters to ligate to blunt-ended nucleic acid molecules that failed to undergo tailing. | 2020-04-30 |
20200131568 | METHODS AND SYSTEMS FOR DETECTING GENETIC VARIANTS - Disclosed herein in are methods and systems for determining genetic variants (e.g., copy number variation) in a polynucleotide sample. A method for determining copy number variations includes tagging double-stranded polynucleotides with duplex tags, sequencing polynucleotides from the sample and estimating total number of polynucleotides mapping to selected genetic loci. The estimate of total number of polynucleotides can involve estimating the number of double-stranded polynucleotides in the original sample for which no sequence reads are generated. This number can be generated using the number of polynucleotides for which reads for both complementary strands are detected and reads for which only one of the two complementary strands is detected. | 2020-04-30 |
20200131569 | SHORT PENDANT ARM LINKERS FOR NUCLEOTIDES IN SEQUENCING APPLICATIONS - The present disclosure relates to new nucleotide and oligonucleotide compounds and their use in nucleic acid sequencing applications. | 2020-04-30 |
20200131570 | METHODS AND COMPOSITIONS FOR IDENTIFYING LIGANDS ON ARRAYS USING INDEXES AND BARCODES - Some embodiments provided herein include methods and compositions for the detection of target ligands on an array. In some embodiments, a capture probe specifically binds to a target ligand from a sample, the location of a bead comprising the capture probe in an array is determined, and the bead is decoded to identify the capture probe and the sample. In some embodiments, a barcode is indicative of a capture probe attached to a bead; and an index is indicative of a subpopulation of beads. In some embodiments, the barcode and the index are determined by sequencing. | 2020-04-30 |
20200131571 | CELL-FREE DNA FOR ASSESSING AND/OR TREATING CANCER - This document relates to methods and materials for assessed, monitored, and/or treated mammals (e.g., humans) having cancer. For example, methods and materials for identifying a mammal as having cancer (e.g., a localized cancer) are provided. For example, methods and materials for assessing, monitoring, and/or treating a mammal having cancer are provided. | 2020-04-30 |
20200131572 | SENSING APPARATUS FOR AMPLIFICATION AND SEQUENCING OF TEMPLATE POLYNUCLEOTIDES AND ARRAY FOR AMPLIFICATION OF TEMPLATE POLYNUCLEOTIDES - Provided is a sensing apparatus comprising a chip for integrated amplification and sequencing of a template polynucleotide in a sample. The apparatus comprises a chip with at least one ISFET in a well or chamber, amplification means for amplifying the template polynucleotide on a surface of said chip and comprising at least one heating means suitable for conducting amplification of the template polynucleotide at temperatures elevated with respect to room temperature, and sequencing means for sequencing the amplified template polynucleotide in said well or chamber. Methods of use are also provided. | 2020-04-30 |
20200131573 | GENETIC VARIANTS ASSOCIATED WITH HUMAN-DIRECTED HYPER-SOCIAL BEHAVIOR IN DOMESTIC DOGS - Disclosed herein are structural variants in the Williams-Beuren Syndrome locuse of the dog genome that are associated with hyper-social behavior in dogs relative to wolves, and that are informative regarding the nature of social behavior in dogs. Disclosed also is a commercial test with these loci as indicators along the spectrum of sociality. Methods of breeding dogs to select for dogs having increased sociability are also disclosed. | 2020-04-30 |
20200131574 | ASSAY FOR DISTINGUISHING BETWEEN SEPSIS AND SYSTEMIC INFLAMMATORY RESPONSE SYNDROME - There is provided a method for distinguishing between sepsis and systemic inflammatory response syndrome (SIRS) in a patient, comprising: (i) determining the amount of one or more biomarker for sepsis, and one or more biomarker for SIRS in a sample obtained from a patient, wherein the one or more biomarker for sepsis is selected from the group consisting of: ITGB3, ITGA2B, MYL9, LCN2, TREML1, LCN15, CMTMS, PPBP, and PF4; and the one or more biomarker for SIRS is selected from the group consisting of: PLA2G7, ARHGEF10L, MYCL, TGFBI, and GPR124, (ii) comparing the amount of the one or more biomarker for sepsis determined in said sample in (i) to a corresponding reference value representative of a healthy individual, (iii) comparing the amount of the one or more biomarker for SIRS determined in said sample in (i) to a corresponding reference value representative of a healthy individual; wherein the patient is diagnosed as having sepsis, when an increase is observed in the one or more biomarker for sepsis, and no increase is observed in the one or more biomarker for SIRS, in the sample obtained from the patient relative to the corresponding reference value; and wherein the patient is diagnosed as having SIRS, when an increase is observed in the one or more biomarker for SIRS, and no increase is observed in the one or more biomarker for sepsis, in the sample obtained from the patient relative to the corresponding reference value. | 2020-04-30 |
20200131575 | DIAGNOSTIC AND TREATMENT METHOD FOR ENDOMETRIAL CAVITY DISTORTING UTERINE LEIOMYOMA USING MICRORNA - The present invention relates to a method of diagnosing and treating endometrial cavity-distorting leiomyoma using microRNA, and particularly, a composition and a kit for diagnosing uterine leiomyoma, the composition and the kit including an agent capable of detecting a microRNA expression level in a biological sample; a method of diagnosing uterine leiomyoma of a subject, the method including measuring a microRNA expression level in a biological sample from the subject, and diagnosing that the subject has uterine leiomyoma having endometrial cavity distortion or uterine leiomyoma having a likelihood of developing endometrial cavity distortion, when the microRNA expression level is downregulated; and a method of treating uterine leiomyoma, the method including measuring a microRNA expression level in a biological sample from a subject, and performing uterine leiomyoma treatment when the microRNA expression level is downregulated. | 2020-04-30 |
20200131576 | IL-8, IL-6, IL-1 Beta and TET2 and DNMT3A in Atherosclerosis - The application presently discloses a method of treating atherosclerosis in a human subject comprising administering an effective amount of an IL-8 inhibitor, an IL-6 inhibitor, and/or an IL-1β inhibitor, wherein the subject has a TET2 and/or DNMT3A mutation thereby treating atherosclerosis. It also discloses a method for treating atherosclerosis in a human subject comprising sequencing at least a part of a genome comprising TET2 and/or DNMT3A of one or more cells in a blood sample of the subject; determining from the sequencing whether the subject has one or more mutations in TET2 and/or DNMT3A, if it is determined that the subject has at least one TET2 and/or DNMT3A mutation, administering an IL-8 inhibitor, an IL-6 inhibitor, and/or an IL-1β inhibitor to a subject to the subject thereby treating atherosclerosis. | 2020-04-30 |
20200131577 | Methods for Diagnosis of Sepsis - Methods for diagnosis of sepsis are disclosed. In particular, the invention relates to the use of biomarkers for aiding diagnosis, prognosis, and treatment of sepsis, and to a panel of biomarkers that can be used to distinguish sepsis from noninfectious sources of inflammation, such as caused by traumatic injury, surgery, autoimmune disease, thrombosis, or systemic inflammatory response syndrome (SIRS). | 2020-04-30 |
20200131578 | METHODS AND ASSAYS RELATING TO THE TREATMENT OF INFECTION - The technology described herein is directed to the diagnosis, prognosis, and treatment of infection, e.g. after burn injury. | 2020-04-30 |
20200131579 | IMPROVED METHOD FOR PROVIDING INFORMATION ON BREAST CANCER AND DIAGNOSTIC KIT THEREFOR - The present disclosure relates to an improved method for providing information on breast cancer and a diagnostic kit therefore, and more specifically, to an improved kit for diagnosing breast cancer by using a one-tube nested PCR and a diagnostic method therefor. | 2020-04-30 |
20200131580 | RISK STRATIFICATION METHOD FOR A PATIENT HAVING A POLYMORPHISM - A risk stratification method for a patient in a disease state and specifically patients presenting a tumor, includes determining if the patient is a homozygote or heterozygote and further determining the allelic expression for the patient, CC, T/C, or C/T. For patients having the cytosine methylated, they have a C/T allelic expression and patients without a methylated cytosine have a T/C allelic expression, A patient with a TT allelic expression is classified as a highest risk patient, a patient with a T/C allelic expression is classified as a second highest risk, patient, a patient with a C/T allelic expression is classified as a third highest risk patient and a patient with a CC allelic expression is classified as a lowest risk patient. The risk stratification method may further include identification of an abnormal expression or mutation/function of a gene product produced by CTCF binding site 6. | 2020-04-30 |
20200131581 | DIGITAL THERAPEUTICS AND BIOMARKERS WITH ADJUSTABLE BIOSTREAM SELF-SELECTING SYSTEM (ABSS) - A system and method for an adjustable bio-stream self-selecting system. Through a plethora of inputs, the system associates therapeutic recipes and associated biomarker in a personalized approach to recommending an individual to a specific therapeutic program. Therapeutic programs operate in accordance with personalized inputs suggested by the user and through digital markers and biomarkers, which trigger new recommendations by “knowing” the individual. Each bio-stream contains information utilized within these biomarkers to trigger additional therapy recommendations. Because of the complexity of the plurality of inputs, these biomarkers are managed in a way that enables low latency detections, low bandwidth needs, low processing needs, and less battery needs. The pre-processing of these biomarkers helps additional therapy management and precision medicine across larger global population needs of the system. | 2020-04-30 |
20200131582 | CELL-FREE DNA METHYLATION PATTERNS FOR DISEASE AND CONDITION ANALYSIS - Disclosed herein are methods and systems of utilizing sequencing reads for detecting and quantifying the presence of a tissue type or a disease type in cell-free DNA prepared from blood samples. | 2020-04-30 |
20200131583 | COMPOSITIONS AND METHODS FOR DETECTING SESSILE SERRATED ADENOMAS/POLYPS - The disclosure provides a method to detect sessile serrated adenomas/polyps (SSA/Ps) and to differentiate SSA/Ps from hyperplastic polyps (HPs). The method uses a molecular signature that is platform-independent and could be used with multiple platforms such as microarray, RNA-seq or real-time quantitative platforms. | 2020-04-30 |
20200131584 | BIOMARKER DLEC1 FOR CANCER - The present invention provides a method for diagnosing and determining prognosis of certain cancers (e.g., esophageal squamous cell carcinoma or ESCC) in a subject by detecting suppressed expression of the DLEC1 gene, which in some cases is due to elevated methylation level in the genomic sequence of this gene. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for treating cancer by increasing DLEC1 gene expression or activity. | 2020-04-30 |
20200131585 | METHODS AND MATERIALS FOR DETECTING COLORECTAL CANCER AND ADENOMA - The present invention provides methods and materials related to the detection of colorectal neoplasm-specific markers (e.g., markers associated with colorectal cancer, markers associated with adenoma) in or associated with a subject's stool sample. In particular, the present invention provides methods and materials for identifying mammals (e.g., humans) having a colorectal neoplasm by detecting the presence and level of indicators of colorectal neoplasia such as, for example, long DNA (e.g., quantified by Alu PCR) and the presence and level of tumor-associated gene alterations (e.g., mutations in KRAS, APC, melanoma antigen gene, p53, BRAF, BAT26, PIK3CA) or epigenetic alterations (e.g., DNA methylation) (e.g., CpG methylation) (e.g., CpG methylation in coding or regulatory regions of bmp-3, bmp-4, SFRP2, vimentin, septin9, ALX4, EYA4, TFPI2, NDRG4, FOXE1) in DNA from a stool sample obtained from the mammal. | 2020-04-30 |
20200131586 | METHODS AND COMPOSITIONS FOR DIAGNOSING OR DETECTING LUNG CANCERS - A multi-analyte composition for the diagnosis of lung cancer or lung disease comprises a ligand selected from a nucleic acid sequence, polynucleotide or oligonucleotide capable of specifically complexing with, hybridizing to, or identifying an mRNA gene transcript from a mammalian blood sample, and an additional ligand selected from a nucleic acid sequence, polynucleotide or oligonucleotide capable of specifically complexing with, hybridizing to, or identifying an miRNA of a gene from a mammalian blood sample. Each ligand and additional ligand binds to a different gene transcript or miRNA and the gene transcripts and miRNA identified form a characteristic profile of a stage of lung cancer or lung disease. Methods of using this composition for diagnosis and evaluation and methods for developing such compositions are described. | 2020-04-30 |
20200131587 | DETECTING NEOPLASM - This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided. | 2020-04-30 |
20200131588 | DETECTING COLORECTAL NEOPLASM - Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as colorectal cancer. | 2020-04-30 |
20200131589 | METHOD FOR EVALUATING HEALTH AND GENETIC PREDISPOSITION OF ANIMALS - The methods of the present invention are based upon the gathering of information from various sources about animals. The information is based upon laboratory testing, genetic analysis and observations by owners and/or trainers about various traits that can be readily observed. Based upon this collection of information, one method generates Performance Index which scores or ranks an animal in terms of how well an animal might function for the intended purpose. Other methods include the ability to selection an optimum breeding pair from one or more stallions and/or one or more mares that would likely produce an offspring with the desired traits. | 2020-04-30 |
20200131590 | Methods, reagents and kits for detection of Karnal bunt - The present disclosure relates to methods and test kits for detecting | 2020-04-30 |
20200131591 | YEAST WITH IMPROVED ALCOHOL PRODUCTION - Described are compositions and methods relating to yeast cells having a genetic mutation that give rise to increased alcohol production. Such yeast is well-suited for use in alcohol production to reduce fermentation time and/or increase yields. | 2020-04-30 |
20200131592 | CRYSTALLIZED OXALATE DECARBOXYLASE AND METHODS OF USE - Pharmaceutical compositions comprising spray-dried oxalate decarboxylase crystals are disclosed. Methods to treat a disorder associated with elevated oxalate concentration using compositions comprising spray-dried oxalate decarboxylase crystals are also disclosed. | 2020-04-30 |
20200131593 | APPARATUSES AND METHODS FOR STRETCHING A PELT ON A PELT BOARD - An apparatus and a method for fixating a stretched pelt on a pelt board by means of a tubular plastics sleeve, which two outwardly extending flanges. The pelt has a substantially tubular shape, which defines an inwardly orientated leather side, an outwardly orientated fur side, a nose end and a rear end. The pelt board defines a top end for accommodating and fixating the nose end of the pelt, a circumferential wall for facing the inwardly orientated leather side of the pelt and a base end located opposite the top end. The apparatus comprises a holding device for holding the base end of the pelt board, and further comprises a fixating device which has a pair of gripping members. Each of the gripping members is adapted for gripping a respective flange of the tubular plastic sleeve, as the sleeve is loosely positioned in a first position at the top end of the pelt board on the pelt at the nose end thereof, and for pulling the flanges apart for widening the tubular plastics sleeve, moving the sleeve from the first position at the top end to a second position at the base end of the pelt board and disengaging the gripping members from the flanges for allowing the sleeve to reform towards its original shape and in doing so, firmly engaging with the outwardly orientated first side of the pelt at the rear end thereof. | 2020-04-30 |
20200131594 | STEEL FOR CRANKSHAFT AND METHOD OF MANUFACTURING CRANKSHAFT USING THE SAME - Steel for a crankshaft includes 0.37 to 0.42 wt % of carbon (C), 0.55 to 0.70 wt % of silicon (Si), 1.45 to 1.65 wt % of manganese (Mn), 0.025 wt % or less (excluding 0 wt %) of phosphorus (P), 0.020 to 0.035 wt % of sulfur (S), 0.15 to 0.30 wt % of chromium (Cr), 0.035 to 0.055% of vanadium (V), and the remainder of Fe and other inevitable impurities. The steel for a crankshaft has strength that is maintained high even when reducing the amount of vanadium. | 2020-04-30 |
20200131595 | AUSTENITIC STAINLESS STEEL SHEET FOR EXHAUST COMPONENT HAVING EXCELLENT HEAT RESISTANCE AND WORKABILITY, TURBOCHARGER COMPONENT, AND METHOD FOR PRODUCING AUSTENITIC STAINLESS STEEL SHEET FOR EXHAUST COMPONENT - The present invention particularly has as its technical problem to provide austenitic stainless steel sheet used as the material for housings of turbochargers in which excellent heat resistance and workability are demanded. The austenitic stainless steel sheet according to the present invention comprises, by mass %, C: 0.005 to 0.2%, Si: 0.1 to 4%, Mn: 0.1 to 10%, Ni: 2 to 25%, Cr: 15 to 30%, N: 0.01 to less than 0.4%, Al: 0.001 to 1%, Cu: 0.05 to 4%, Mo: 0.02 to 3%, V: 0.02 to 1%, P: 0.05% or less, and S: 0.01% or less, comprises a balance of Fe and unavoidable impurities, and has an annealing twin frequency of 40% or more and is excellent in heat resistance. | 2020-04-30 |
20200131596 | HOT-PRESSED MEMBER AND METHOD FOR MANUFACTURING SAME, AND COLD-ROLLED STEEL SHEET FOR HOT PRESSING AND METHOD FOR MANUFACTURING SAME - Disclosed is a hot-pressed member that can exhibit very high tensile strength after hot pressing as high as TS: 1780 MPa or more and excellent delayed fracture resistance after projection welding by properly adjusting its chemical composition and its microstructure such that at least 5 Ti-based precipitates having a grain size of 0.10 μm or less are present on average per 100 μm | 2020-04-30 |
20200131597 | HOT-PRESSED MEMBER AND METHOD FOR MANUFACTURING SAME, AND COLD-ROLLED STEEL SHEET FOR HOT PRESSING AND METHOD FOR MANUFACTURING SAME - Disclosed is a hot-pressed member that can exhibit very high tensile strength after hot pressing as high as TS: 1780 MPa or more, and excellent resistance to resistance welding cracking by properly adjusting its chemical composition and its microstructure such that a prior austenite average grain size is 7.5 μm or less, a volume fraction of martensite is 95% or more, and at least 10 Nb-based and Ti-based precipitates having a grain size of less than 0.10 μm are present on average per 100 μm | 2020-04-30 |
20200131598 | CONTINUOUS ANNEALING OR GALVANISING LINE COMPRISING A TENSIONING BLOCK BETWEEN TWO CONSECUTIVE FURNACES - Continuous annealing or galvanizing line for metal strips with at least two consecutive annealing furnaces, a tensioning unit with at least two rollers located between the two annealing furnaces, and a production control and optimization system for said line. | 2020-04-30 |
20200131599 | Method for operating an annealing furnace - A method for operating an annealing furnace to anneal a metal strip provides that, initially, at least one target material property (MP | 2020-04-30 |
20200131600 | A METHOD FOR PREPARING A LEACH FEED MATERIAL | 2020-04-30 |
20200131601 | ON-LINE ALUMINUM SCRAP REMELTING DEVICE AND PROCESS - The present application discloses an on-line aluminum scrap remelting device, comprising an aluminum scrap conveying device, a primary aluminum scrap purification device, a remote aluminum scrap transport device, an ultimate aluminum scrap purification device, and a feed remelting device. The application further discloses an on-line aluminum scrap remelting process, comprises machined scrap removal, underground aluminum scrap transport collection, temporary storage, crushing, spin-drying, remote transport, secondary magnetic separation, drying, weighing, remelting, tempering, and use. | 2020-04-30 |
20200131602 | RECOVERY OF URANIUM - A process is provided for recovering uranium comprising
| 2020-04-30 |
20200131603 | METAL ALLOYS - Metal alloys including platinum are disclosed. The alloys have a similar variety of applications to platinum-based alloys. The alloy with a solid solution matrix consisting of: Platinum (Pt) 20 to 70 at. %; Palladium (Pd)>0 to 70 at. %; Cobalt (Co)>0 to 50 at. % and at least one of: Nickel (Ni) up to 50 at. %; Chromium (Cr) up to 50 at. % and Iron up to 50 at. %. | 2020-04-30 |
20200131604 | POWDER ALLOY COMPOSITION, GAS TURBINE ENGINE COMPONENT AND METHOD FOR MANUFACTURE OF THE SAME - A Ni-based superalloy powder having a freezing range of not more than 80° C. is disclosed, with a composition, expressed in weight percent, of: Ni; 9-25 Co; 3-15 Cr; 0-5 Mo; 0-12 W; 3-9 Al; 0-6.5 Nb; 0.3-1 C; 0-6.5 Ta; 0-3 Ti, and incidental impurities. It is disclosed in methods for manufacturing or repair of gas turbine engine components such as gas turbine blades using additive layer manufacturing techniques. | 2020-04-30 |
20200131605 | ALUMINUM ALLOY - An aluminum alloy is provided including between about 7.5-9.5 wt. % silicon, between about 3.0-4.0 wt. % copper, and between about 0.01-5.0 wt. % titanium. The aluminum alloy may include up to about 1.3 wt. % iron, up to about 0.5 wt. % manganese, up to about 0.1 wt. % magnesium, up to about 3.0 wt. % zinc, and up to about 0.35 wt. % tin. The balance of the aluminum alloy may include aluminum. | 2020-04-30 |
20200131606 | HIGH-STRENGTH NODULAR IRON WITH GOOD WELDABILITY AND MACHINABILITY - A nodular iron alloy and automotive components, such as differential and drive axle components, are provided. The nodular iron alloy may include iron, about 3.1-3.3 wt % carbon, about 2.7-4.3 wt % silicon, about 0.15-0.40 wt % manganese, about 0-0.10 wt % magnesium, about 0-0.2 wt % nickel, about 0-0.4 wt % copper, about 0-0.30 wt % chromium, about 0-0.03 wt % phosphorus, and about 0-0.02 wt % sulfur. The nodular iron alloy may have an ultimate tensile strength of at least 620 MPa as-cast. This alloy possesses favorable weldability to weld with steel components without substantial preheating or post heat treatment for a strong and tough weldment, and it has good machinability to facility comprehensive machining operations. | 2020-04-30 |
20200131607 | HIGH FORMABILITY STEEL SHEET FOR THE MANUFACTURE OF LIGHTWEIGHT STRUCTURAL PARTS AND MANUFACTURING PROCESS - A steel sheet has a composition comprising, by weight: 0.010%≤C≤0.080%, 0.06%≤Mn≤3%, Si≤1.5%, 0.005%≤Al≤1.5%, S≤0.030%, P≤0.040%, Ti and B such that: 3.2%≤Ti≤7.5% and (0.45×Ti)−1.35≤B≤(0.45×Ti)−0.43, optionally Ni≤1%, Mo≤1%, Cr≤3%, Nb≤0.1%, V≤0.1%, the remainder being iron and unavoidable impurities resulting from the smelting. The steel sheet has a structure consisting of ferrite, at most 10% of austenite, and precipitates comprising eutectic precipitates of TiB | 2020-04-30 |
20200131608 | METHOD OF DETERMINING A COMPOSITION OF A STEEL ALLOY FOR USE IN A LOW-ALLOY HIGH-STRENGTH STEEL - A method of determining a composition of a steel alloy includes minimizing a presence of AlN by satisfying the following condition: Al×N<5×10 | 2020-04-30 |
20200131609 | HIGH-STRENGTH STEEL MEMBER - A high-strength steel member having a predetermined chemical composition, having a tensile strength of 1,000 MPa or higher, containing 0.10% or more of, in terms of percent (%) by area, at least one Ti precipitate that has an average size of from 30 to 200 nm in terms of an average equivalent circle diameter and is selected from the group consisting of a Ti carbide, a Ti nitride, and a composite compound thereof, at a location of 1 mm in depth from a surface of the steel member, and containing 0.5 ppm by mass or more of non-diffusible hydrogen that is released in a temperature range of from 400 to 800° C. in a thermal desorption hydrogen analysis. | 2020-04-30 |
20200131610 | HIGH-Mn AUSTENITIC STAINLESS STEEL FOR HYDROGEN HAVING EXCELLENT WELDABILITY, WELDED JOINT USING SAME, DEVICE FOR HYDROGEN USING SAME, AND METHOD FOR PRODUCING WELDED JOINT - This austenitic stainless steel contains, by mass %: C: 0.3% or less, Si: 0.1% to 1.5%, Mn: 5.5% to 20%, P: 0.050% or less, S: 0.005% or less, Cr: 10% to 20%, Ni: 4.0% to 12%, N: 0.40% or less, Cu: 4.0% or less, O: 0.02% or less, and either one or both of Ca: 0.01% or less and Al: 0.3% or less, with a remainder being Fe and inevitable impurities, and the following Formula (1) is satisfied. | 2020-04-30 |
20200131611 | ECAE PROCESSING FOR HIGH STRENGTH AND HIGH HARDNESS ALUMINUM ALLOYS - A method of forming a high strength aluminum alloy is disclosed. The method includes solutionizing to a temperature ranging from about 5° C. above a standard solutionizing temperature to about 5° C. below an incipient melting temperature for the aluminum material to form a heated aluminum material, which is then quenched. The aluminum material includes at least one of magnesium and silicon as a secondary component at a concentration of at least 0.2% by weight. The cooled aluminum material is subjected to ECAE processing using one of isothermal conditions and non-isothermal conditions. Isothermal conditions include having a billet and a die at the same temperature from about 80° C. to about 200° C. Non-isothermal conditions include having a billet at a temperature from about 80° C. to about 200° C. and a die at a temperature of at most 100° C. The aluminum material is than aged at a temperature from about 100° C. to about 175° C. | 2020-04-30 |
20200131612 | AL-ZN-CU-MG ALLOYS AND THEIR MANUFACTURING PROCESS - The invention concerns an extruded, rolled and/or forged aluminum-based alloy product having a thickness of at least 25 mm comprising (in weight %): Zn 6.70-7.40; Mg 1.50-1.80; Cu 2.20-2.60, with a Cu to Mg ratio of at least 1.30; Zr 0.04-0.14; Mn 0-0.5; Ti 0-0.15; V 0-0.15; Cr 0-0.25; Fe 0-0.15; Si 0-0.15; impurities ≤0.05 each and ≤0.15 total. The invention also concerns a method of making such a product. Products according to the invention are particularly advantageous because they exhibit simultaneously a low sensitivity to environmentally assisted cracking under conditions of high stress and humid environment, high strength and high toughness properties. | 2020-04-30 |
20200131613 | HIGH GAMMA PRIME NICKEL BASED SUPERALLOY, ITS USE, AND METHOD OF MANUFACTURING OF TURBINE ENGINE COMPONENTS - The invention is related to a high gamma prim nickel based superalloy, its use and a method of manufacturing of turbine engine components by welding, 3D additive manufacturing, casting and hot forming, and the superalloy comprises 9.0-10.5 wt. % Cr, 20-22 wt. % Co, 1.0-1.4 wt. % Mo, 5.0-5.8 wt. % W, 2.0-6.0 wt. % Ta, 3.0-6.5 wt. % Al, 0.2-0.5 wt. % Hf, 0.01-0.16 wt. % C, 1.5-3.5 wt. % Re, 0-1.0 Ge wt. %, 0-0.2 wt. % Y, 0-1 wt. % Si, 0-0.015 wt. % B and nickel with impurities to balance. | 2020-04-30 |
20200131614 | MANUFACTURING PROCESS OF Ni BASED SUPERALLOY MEMBER, BOILER TUBE, COMBUSTOR LINER, GAS TURBINE BLADE, AND GAS TURBINE DISK - To provide a manufacturing process of a Ni based superalloy and a member of the Ni based superalloy which achieves both of excellent workability in a manufacturing step of the Ni based superalloy of the precipitation strengthening type which contains much amount of the gamma prime phase and excellent high temperature strength of the Ni based superalloy. | 2020-04-30 |
20200131615 | METHOD OF THERMAL SPRAY COATING FIBER-REINFORCED COMPOSITE MATERIALS - A method of coating a fiber-reinforced composite material includes providing a fiber-reinforced composite workpiece, treating a surface of the workpiece to remove at least a portion of a polymer matrix and to expose fibers to a treated surface of the workpiece, and coating the treated surface of the workpiece using a thermal spray coating process. The treatment can include laser ablating or applying a peel ply process. The method yields a coated fiber-reinforced composite workpiece with the coating being bonded directly to the fibers via diffusion of the coating into the fibers, the formation of an intermediate compound at an interface of the coating and the fibers, or both. | 2020-04-30 |
20200131616 | OXIDATION RESISTANT COATING AND METHODS OF MANUFACTURING THEREOF - There is described a method of forming an oxidation resistant coating on a cermet comprising tungsten carbide, tungsten boride, or boron carbide and a metallic binder material. The method comprises exposing the cermet to silicon in the presence of an activator to form a mixture, exposing the mixture to an inert gas, and heating the mixture to a temperature T for a time t, thereby forming a coating on the cermet. | 2020-04-30 |
20200131617 | Direct-Deposition System Including Standoffs for Controlling Substrate-Mask Separation - The present disclosure enables high-resolution direct patterning of a material on a substrate by establishing and maintaining a separation between a shadow mask and a substrate based on the thickness of a plurality of standoffs. The standoffs function as a physical reference that, when in contact between the substrate and shadow mask determine the separation between them. Embodiments are described in which the standoffs are affixed to an element selected from the shadow mask, the substrate, the mask chuck, and the substrate chuck. | 2020-04-30 |
20200131618 | MASK REPAIRING APPARATUS AND MASK REPAIRING METHOD - A mask repairing apparatus may include a stage, a stereoscopic imaging unit to measure a stereoscopic image of a mask on the stage, a control unit to compare the stereoscopic image with a normal image of the mask and to produce a defect image of the mask, and a laser unit to irradiate a laser beam onto a deficient part of the mask, under control of the control unit. The control unit may control the laser unit, based on the defect image, such that the laser beam is sequentially irradiated onto m multiple layers of the deficient part while repeatedly moving in a first direction and a second direction crossing each other. | 2020-04-30 |
20200131619 | FUNCTIONALLY INTEGRATED COATING STRUCTURES - Techniques for depositing a functionally integrated coating structure on a substrate are provided. An example method according to the disclosure includes receiving the substrate into a process chamber of a multi-process ion beam assisted deposition system, disposing the substrate in a first zone including a first evaporator species and a first ion beam, wherein the first evaporator species is Aluminum Oxide (Al2O3), disposing the substrate in a second zone including a second evaporator species and a second ion beam, wherein the second evaporator species is Yttrium Oxide (Y2O3), and disposing the substrate in a third zone including a third evaporator species and a third ion beam, wherein the third evaporator species is Yttrium Fluoride (YF3). | 2020-04-30 |
20200131620 | PVD SYSTEM WITH REMOTE ARC DISCHARGE PLASMA ASSISTED PROCESS - An arc coating system includes a coating chamber having a peripheral chamber wall, a top wall, and a bottom wall. The peripheral chamber wall, the top wall, and the bottom wall define a coating cavity and a chamber center. A plasma source is positioned at the chamber center wherein the plasma source comprises a central cathode rod and a plurality of cathode rods surrounding the central cathode rod. The coating system also includes a sample holder that holds a plurality of substrates to be coated. Characteristically, the sample holder rotatable about the chamber center at a first distance from the chamber center. | 2020-04-30 |
20200131621 | PLASMA CORRIDOR FOR HIGH VOLUME PE-CVD PROCESSING - A coating system includes a coating chamber having a peripheral chamber wall, a top wall, and a bottom wall. The peripheral chamber wall defines a chamber center. A plasma source is positioned at the chamber center. The coating system also includes a sample holder that holds a plurality of substrates to be coated which is rotatable about the chamber center at a first distance from the chamber center. A first isolation shield is positioned about the chamber center at a second distance from the chamber center, the first isolation shield being negatively charged. | 2020-04-30 |
20200131622 | Tantalum Sputtering Target - Provided is a tantalum sputtering target that contributes to improvement of film thickness uniformity during a high-power sputtering. A tantalum sputtering target having a purity of 99.99% by mass or more and an average value of Vickers hardness on a sputtering surface of from 85 to 110 Hv, the tantalum sputtering target satisfying both of the following conditions (1) and (2):
| 2020-04-30 |
20200131623 | TARGET FOR OBTAINING COLOURED GLAZING - A cathode sputtering target is formed, on the one hand, from an oxide of at least one element chosen from the group of titanium, silicon and zirconium and, on the other hand, of particles of a metal included in the group formed by silver, gold, platinum, copper and nickel or particles of an alloy formed from at least two of these metals, the atomic ratio M/Me in the target being less than 1.5, M representing all of the atoms of the elements of the group of titanium, silicon and zirconium present in the layer and Me representing all of the atoms of the metals of the group formed by silver, gold, platinum, copper and nickel present in the layer. | 2020-04-30 |
20200131624 | METHODS AND APPARATUS FOR CONTROLLING WARPAGE IN WAFER LEVEL PACKAGING PROCESSES - Methods and apparatus for producing fine pitch patterning on a substrate. Warpage correction of the substrate is accomplished on a carrier or carrier-less substrate. A first warpage correction process is performed on the substrate by raising and holding a temperature of the substrate to a first temperature and cooling the carrier-less substrate to a second temperature. Further wafer level packaging processing is then performed such as forming vias in a polymer layer on the substrate. A second warpage correction process is then performed on the substrate by raising and holding a temperature of the substrate to a third temperature and cooling the substrate to a fourth temperature. With the warpage of the substrate reduced, a redistribution layer may be formed on the substrate with a 2/2 μm l/s fine pitch patterning. | 2020-04-30 |
20200131625 | STAGE DEVICE AND PROCESSING APPARATUS - A stage device includes a stage configured to hold a target substrate in a vacuum chamber, a chiller having a cold head maintained at an extremely low temperature and a cold heat transfer body fixed in contact with the cold head and disposed below a bottom surface of the stage with a gap between the stage and the cold heat transfer body. The stage device further includes a heat insulating structure unit having a vacuum insulated structure and configured to surround at least the cold head and a connection portion between the cold head and the cold heat transfer body, cooling fluid supplied to the gap to transfer cold heat of the cold heat transfer body to the stage, and a stage support rotated by a driving mechanism and configured to rotatably support the stage. | 2020-04-30 |
20200131626 | FILMS AND LAMINATES WITH HIGH OXYGEN BARRIER AND METHODS OF MAKING THE SAME - Disclosed is a laminated film for use to form a flexible package for holding an oxygen sensitive product and methods of making the film. The film includes a metalizable polymer film or cellulose film with aluminum vacuum deposited thereon. An acidic layer of polyvinyl alcohol and a polymer is coated on aluminum to cause a portion of the aluminum to be converted into an inorganic aluminum compound, whereupon said laminated film has a higher oxygen barrier value than the sum of the oxygen barrier values of its individual components Also disclosed are methods for making the laminated film. | 2020-04-30 |
20200131627 | HEAT TREATMENT APPARATUS FOR A VACUUM CHAMBER, DEPOSITION APPARATUS FOR DEPOSITING MATERIAL ON A FLEXIBLE SUBSTRATE, METHOD OF HEAT TREATMENT OF A FLEXIBLE SUBSTRATE IN A VACUUM CHAMBER, AND METHOD FOR PROCESSING A FLEXIBLE SUBSTRATE - The present disclosure provides a heat treatment apparatus ( | 2020-04-30 |
20200131628 | METHOD FOR FORMING MOLYBDENUM FILMS ON A SUBSTRATE - A process for forming a molybdenum-containing material on a substrate is described, in which the substrate is contacted with molybdenum dioxydichloride (MoO | 2020-04-30 |
20200131629 | CLEANING METHOD OF A THIN FILM DEPOSITION CHAMBER AND METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE USING THE CLEANING METHOD - A cleaning method of a thin film deposition chamber may include i) simultaneously providing oxygen plasma and fluorine plasma in a thin film deposition chamber to at least partially remove a first residue including carbon (C) and a second residue including silicon (Si) in the thin film deposition chamber, and ii) providing fluorine plasma without oxygen plasma in the thin film deposition chamber to remove the second residue remaining in the thin film deposition chamber. | 2020-04-30 |
20200131630 | AEROSOL-FREE VESSEL FOR BUBBLING CHEMICAL PRECURSORS IN A DEPOSITION PROCESS - Described herein are aerosol-free vessels, delivery containers, systems and methods using same for providing improvements to precursor utilization in the containers for deposition process, as well as the cleaning and refilling of the containers. The clogging of valves and piping as some precursors decompose vapor are minimized. This invention prevents mist from forming and thus preventing clogging or wafer contamination from aerosols. | 2020-04-30 |