18th week of 2020 patent applcation highlights part 10 |
Patent application number | Title | Published |
20200129625 | GLYCOTARGETING THERAPEUTICS - Several embodiments of the present disclosure relate to therapeutic compositions configured to target the liver of a subject and that are useful in the treatment or prevention of one or more of transplant rejection, autoimmune disease, food allergy, and immune response against a therapeutic agent. In several embodiments, the compositions are configured to target the liver and deliver antigens to which tolerance is desired. In several embodiments, the compositions are configured for clearance of a circulating protein or peptide or antibody associated with one or more of the above-mentioned maladies. Methods and uses of the compositions for induction of immune tolerance are also disclosed herein. | 2020-04-30 |
20200129626 | ANTICANCER PRODRUG FOR OVERCOMING DRUG RESISTANCE - Disclosed is an anticancer prodrug that disturbs energy metabolism in cancer cells to overcome drug resistance. The anticancer prodrug has a structure including a pyruvate dehydrogenase kinase (PDK) inhibitor moiety, a mitochondrial targeting group, and an anthracycline moiety reversibly connected to the PDK inhibitor moiety and the targeting group. | 2020-04-30 |
20200129627 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES - The present disclosure relates to bifunctional compounds, which find utility as modulators of Rapidly Accelerated Fibrosarcoma (RAF, such as c-RAF, A-RAF and/or B-RAF; the target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein RAF, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein, or the constitutive activation of the target protein, are treated or prevented with compounds and compositions of the present disclosure. | 2020-04-30 |
20200129628 | METHODS AND IMMUNOGENIC COMPOSITIONS RELATING TO HER2 WITH SELECTIVE SEQUENCE MODIFICATIONS - Zwitterionic monomers, carnitine-derived zwitterionic polymers, carnitine ester cationic monomers, carnitine ester cationic polymers, conjugate compositions including a carnitine-derived zwitterionic polymer, and related compositions' and methods are provided which have various uses including as coatings, pharmaceuticals, diagnostics, encapsulation materials, and antifouling materials, among other utilities. | 2020-04-30 |
20200129629 | GLYCOTARGETING THERAPEUTICS - Several embodiments of the present disclosure relate to glycotargeting therapeutics that are useful in the treatment of transplant rejection, autoimmune disease, food allergy, and immune response against a therapeutic agent. In several embodiments, the compositions are configured to target the liver and deliver antigens to which tolerance is desired. Methods and uses of the compositions for induction of immune tolerance are also disclosed herein. | 2020-04-30 |
20200129630 | METHODS FOR TREATING CANCER - The present invention relates to a method of treating cancer in a subject. | 2020-04-30 |
20200129631 | PYRROLOQUINOLIN COMPOUNDS AND METHODS OF USING SAME - Provided are pyrroloquinolin compounds of formula (1) or (II). In certain aspects, the pyrroloquinolin compounds are therapeutic, e.g., for treating a cell proliferative disorder. Also provided are conjugates that include the pyrroloquinolin compounds of the present disclosure. Compositions, e.g., pharmaceutical compositions, that include the pyrroloquinolin compounds and conjugates of the present disclosure are also provided. Further provided are therapeutic methods involving the administration of the pyrroloquinolin compounds, conjugates or compositions of the present disclosure. Kits that include the pyrroloquinolin compounds, conjugates or compositions are also provided. | 2020-04-30 |
20200129632 | ANTIBODY DRUG CONJUGATES - The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer. | 2020-04-30 |
20200129633 | PHARMACEUTICAL COMPOSITION COMPRISING C-MET ANTIBODY-DRUG CONJUGATE AND USE THEREOF - A stable c-Met antibody-drug conjugate (c-Met ADC) formulation and use thereof in medicine are described. In particular, the formulation contains c-Met ADC, a buffer, and can also contains at least one stabilizer, and optionally a surfactant. The c-Met ADC formulation of the application can effectively inhibit the aggregation and isomerization of antibodies, and prevent the degradation of an antibody product therein, being a stable injectable pharmaceutical formulation. | 2020-04-30 |
20200129634 | ANTIMICROBIAL PEPTIDES AND METHODS OF TREATING GRAM-NEGATIVE PATHOGENS: POLAR AND NON-POLAR FACE ANALOGS - Antimicrobial agents, including antimicrobial peptides (AMPs), and uses thereof. Compositions and methods of using dermaseptin-type and piscidin-type antimicrobial peptide variants that demonstrate activity and improved therapeutic indices against microbial pathogens. The peptide compositions demonstrate the ability to not only maintain or improve antimicrobial activity against bacterial pathogens including Gram-negative microorganisms | 2020-04-30 |
20200129635 | CYSTEINE MODIFIED ANTIBODY-DRUG CONJUGATE AND PREPARATION METHOD THEREOF - By inserting cysteine (C) into a heavy chain and/or a light chain of a target antibody at specific insertion site, and performing a site-specific conjugation through a free thiol group (—SH) from the site-specific inserted cysteine and a linker conjugated with a highly potent small molecule cytotoxin, a cysteine modified antibody-drug conjugate with good homogeneity is provided. The specific insertion sites of cysteine are position 205 and/or position 206 (Kabat numbering scheme) of the light chain of the antibody, and/or position 439 (Kabat numbering scheme) of the heavy chain | 2020-04-30 |
20200129636 | METHODS FOR DNA-DEPENDENT TARGETING OF A CELL PERMEANT ANTIBODY - The invention provides methods for selective targeting of live cells, which have undergone or are undergoing radiation or chemotherapy, at a site of interest with a cell-penetrating polypeptide. In one embodiment of the invention, the method comprises contacting the live cells with a cell-penetrating polypeptide comprising cell-penetrating determinants so that the cell-penetrating polypeptide binds extracellular DNA near or around the live cells so as to form a complex or association therewith such that the complex or associated polypeptide-DNA so bound bind the live cells and penetrates the live cells thereby selectively targeting live cells at a site of interest with a cell-penetrating polypeptide. | 2020-04-30 |
20200129637 | COMBINATION THERAPY WITH AN ANTI-AXL ANTIBODY-DRUG CONJUGATE - The present disclosure relates to combination therapies for the treatment of pathological conditions, such as cancer. In particular, the present disclosure relates to combination therapies comprising treatment with an Antibody Drug Conjugate (ADC) and a secondary agent. | 2020-04-30 |
20200129638 | COMBINATION THERAPY WITH AN ANTI-PSMA ANTIBODY-DRUG CONJUGATE - The present disclosure relates to combination therapies for the treatment of pathological conditions, such as cancer. In particular, the present disclosure relates to combination therapies comprising treatment with an Antibody Drug Conjugate (ADC) and a secondary agent. | 2020-04-30 |
20200129639 | MULTI-DRUG ANTIBODY DRUG CONJUGATES - The present disclosure provides, inter alia, multi-drug Antibody Drug Conjugates (MD-ADCs) and Linking Assembly (LA) Units, that are constructed in a site-specific matter via ‘orthogonal’ deprotection and drug loading. Also provided are, Protected Linking Assembly Units, which allow for ‘orthogonal’ deprotection and construction of MD-ADCs and LA Units of the present disclosure. | 2020-04-30 |
20200129640 | COMPLEXES FOR DELIVERY OF ANTIGENIC PEPTIDES - The present invention provides methods, compositions, systems, and kits comprising nano-satellite complexes and/or serum albumin carrier complexes, which are used for modulating antigen-specific immune response (e.g., enhancing anti-tumor immunity). In certain embodiments, the nano-satellite complexes comprise: a) a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core; b) at least one satellite particle attached to, or absorbed to, the biocompatible coating; and c) an antigenic component conjugated to, or absorbed to, the at least one satellite particle component. In certain embodiments, the complexes further comprise: d) an type I interferon agonist agent. In some embodiments, the serum albumin complexes comprise: a) at least part of a serum albumin protein, b) an antigenic component conjugated to the carrier protein, and c) a type I interferon agonist agent. | 2020-04-30 |
20200129641 | ENGINEERING SYNTHETIC BRAIN PENETRATING GENE VECTORS - A synthetic gene delivery platform with a dense surface coating of hydrophilic and neutrally charged PEG, capable of rapid diffusion and widespread distribution in brain tissue, and highly effective gene delivery to target cells therein has been developed. Nanoparticles including nucleic acids, are formed of a blend of biocompatible hydrophilic cationic polymers and they hydrophilic cationic polymer conjugated to hydrophilic neutrally charged polymers such as polyethylene glycol. The nanoparticles are coated with polyethylene glycol at a density that imparts a near neutral charge and optimizes rapid diffusion through the brain parenchyma. Methods of treating a disease or disorder of the brain including administering a therapeutically effective amount of nanoparticles densely coated with polyethylene glycol are also provided. | 2020-04-30 |
20200129642 | Resorbable Implant Material Made From Magnesium Or A Magnesium Alloy - The present invention relates to a resorbable implant material made of magnesium or magnesium alloy and to a process for the production thereof. A disadvantage of the known resorbable implants is that their resorption has hitherto only been trackable using x-ray or CT examinations. The invention provides a resorbable implant material comprising homogeneously distributed fluorescent nanodiamonds in a matrix of magnesium or a magnesium alloy. Fluorescent nanodiamonds are biologically nonhazardous and provide a stable emission in the near infrared range due to nitrogen-vacancy centers (NV centres). This allows detection of the implant material in the blood plasma of the patient. | 2020-04-30 |
20200129643 | SOLID ORAL COMPOSITION CONTAINING DYES FOR USE IN ENDOSCOPIC DIAGNOSIS - Herein described are solid oral compositions of dyes for use in diagnostic endoscopy, preferably colon endoscopy. | 2020-04-30 |
20200129644 | IMIDAZOPYRAZINE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND THEIR USES AS LUCIFERINS - The present invention is in the field of bioluminescence in biology and/or medicine. In particular, the invention provides imidazopyrazine derivatives, processes for preparation thereof, and their uses as luciferins. | 2020-04-30 |
20200129645 | CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING - The present invention provides contrast agents of the formula [N(A | 2020-04-30 |
20200129646 | Radioactive labeled long-acting peptide targeted pharmaceutical and production method thereof - A radioactive labeled long-acting peptide-targeting pharmaceutical and production method, in which the peptide targeted pharmaceutical is firstly dissolved in a solution, followed by labeling the radioactive at a high temperature, and the dosage of the pharmaceutical with radioactive labeling is expected to be reduced and labeling efficiency is improved, and no further purification by filtration is required, which shortens the preparation process and reduces personnel exposure in the working environment. The radioactive labeled long-acting peptide-targeting pharmaceutical can increase the specific binding capacity of tumors and reduce the non-specific accumulation in normal tissues. It can be applied to the field of tumor and nuclear medicine for diagnosis and treatment of tumors and/or tumor metastases with efficacy and precision treatment. | 2020-04-30 |
20200129647 | METHODS FOR DETERMINING BIODISTRIBUTION OF INTRAVITREAL ADMINISTERED MEDICAMENTS - Methods for determining systemic biodistribution characteristics of intravitrially administered medicaments. In some embodiments, radiolabeled agents or medicaments, such as I-124 labeled bevacizumab, ranibizumab and aflibercept, was imaged utilizing PET/CT in a non-human primate model, with radioactivity emission measurements made to determine the intravitreal half-lives of each agent and to determine the differences of radioactivity uptake in non-ocular organs. | 2020-04-30 |
20200129648 | Sterilization of Medical Dressings with Enhanced Antimicrobial Properties - The present invention relates to a sponge dressing for treating wounds comprised of a polymer sponge containing a plurality of antimicrobial dyes with at least one dye being gram positive and at least one other dye being gram negative and a silicon adhesive secured to a sponge surface. The sponge dressing can be exposed initially to gamma radiation and later sterilized by ethylene oxide or alternatively it can be sterilized by ethylene oxide and later irradiated by gamma radiation. The sponge dressing has a morphology characterized by an average pore throat diameter of 0.5-500 μm and a porosity ranging from about 60% to about 99.5%. The sponge dressing can also contain at least one biofilm reducing agent, at least one chelating agent and an ionic and non-ionic surfactant. | 2020-04-30 |
20200129649 | PROPYLENE-ETHYLENE RANDOM COPOLYMER WITH IMPROVED IRRADIATION RESISTANCE - The present invention deals with a new unimodal propylene-ethylene random copolymer providing improved resistance against gamma irradiation as well as compositions comprising the new unimodal propylene-ethylene random copolymer and final articles made therefrom. | 2020-04-30 |
20200129650 | MASK STORAGE APPARATUS - A mask storage apparatus includes a body including an accommodation space in which a mask device is stored. A cover is rotatably connected to the body and is capable of opening and closing the accommodation space. A compartment extends from an inner surface of the body and partitions the accommodation space into a first accommodation space in which a part of the mask device is accommodated, and a second accommodation space in which a remaining part of the mask device is accommodated. The compartment includes a sterilization module to sterilize the mask device. | 2020-04-30 |
20200129651 | APPARATUS AND METHOD FOR DETECTING IMPROPER POSITIONING OF REMOVABLE COMPONENT OF STERILIZING SYSTEM - A sterilization system includes a sterilization chamber, a processor, and a sterilization module. The sterilization module includes a frame assembly, an extraction assembly, and a carriage assembly. The extraction assembly is configured to extract a sterilant fluid from a cartridge and transfer the sterilant fluid to the sterilization chamber. The carriage assembly includes a motor, a carriage body, and a translating flag. The carriage body is configured to receive the cartridge. The translating flag is configured to move from a first position to a second position relative to the carriage body in response to the carriage body receiving the cartridge. The sensor is configured to detect movement of the translating flag from the first position to the second position. | 2020-04-30 |
20200129652 | Method and System for Generating Non-Thermal Plasma - Disclosed herein are apparatuses and methods for generating non-thermal plasma which can form reactive oxygen species (ROS), such as those used to neutralize bacteria and other pathogens in the air and surrounding area. Also disclosed are apparatuses and methods for neutralizing bacteria and other pathogens using ROS generated through the use of non-thermal plasma. Also disclosed are apparatuses and methods for generating ROS. Also disclosed are apparatuses and methods for treating air and nearby surfaces. Also disclosed herein are apparatuses for generating non-thermal plasma, and which can monitor and analyze the operational characteristics of a plasma field generated by the aforementioned devices and/or the electrical consumption characteristics of the power supply being used to generate the plasma field, which analyzed characteristics can be used to trigger an alarm to indicate that the device is not functioning optimally or as otherwise expected. | 2020-04-30 |
20200129653 | AN INSTRUMENT CASSETTE FOR HANDLING INSTRUMENTS - An instrument cassette ( | 2020-04-30 |
20200129654 | Dressing Providing for the Controlled and Sustained Release of Metformin - The present invention relates to a dressing providing for the controlled and sustained release of metformin. | 2020-04-30 |
20200129655 | FOAM IN WOUND TREATMENT - The present invention relates to a hydrophilic foam material, which is of particular use in wound treatment, and to a method for producing said hydrophilic foam material. The hydrophilic foam material has nucleating particles, wherein at least 85% of all foam cells in said foam material have an average cell size of 0.01 mm | 2020-04-30 |
20200129656 | ENZYMATIC WOUND DEBRIDING COMPOSITIONS WITH ENHANCED ENZYMATIC ACTIVITY - The present invention is directed to topical enzymatic wound debriding compositions with enhanced enzymatic activity. These compositions comprise a dispersed phase comprising at least one proteolytic enzyme and at least one hydrophilic polyol; and a continuous phase comprising a hydrophobic base. | 2020-04-30 |
20200129657 | ABSORBENT ARTICLE INCLUDING HYDROPHOBIZED ADSORBENT - An objective of the present invention is to provide an absorbent article that prevents wetting of the outer sides or surrounding area of the absorbent article due to condensation formed by water vapor escaped from inside the absorbent article. The present invention provides an absorbent article comprising: an absorbent body composed of at least one absorption layer, wherein the absorbent body includes a hydrophobized adsorbent and (a) a water absorbent resin powder having an absorption speed in a range from 6 seconds to 60 seconds determined by a vortex method. | 2020-04-30 |
20200129658 | ABSORBENT ARTICLE WITH GRAPHICS PRINTED IN PRESERVATIVE-FREE INK, AND METHODS OF MANUFACTURE THEREOF - Absorbent articles having components bearing graphics printed using particular inkjet ink compositions and fluid sets are disclosed. The aqueous inkjet ink compositions may include a composition consisting of one or more compounds represented by the following Structure I: | 2020-04-30 |
20200129659 | DISSOLVABLE NASAL SINUS SPONGE - An implantable article comprising a dissolvable sponge derived from the mixture of chitosan, a first polysaccharide and a second polysaccharides. The polysaccharides have different number average molecular weight characteristics to enable the control of the mechanical features of the sponge. | 2020-04-30 |
20200129660 | BIOADHESIVE HYDROGELS - A bioadhesive includes a crosslinked biodegradable hydrogel that includes a plurality of oxidized, acrylated or methacrylated, natural polymer. | 2020-04-30 |
20200129661 | NERVE REPAIR CONDUITS INCORPORATING SILICA FIBERS - Embodiments of the invention include nerve-repair conduits incorporating mats, sheets, and/or powders of silica fibers and methods for producing such conduits. The silica fibers may be formed via electrospinning of a sol gel produced with a silicon alkoxide reagent, such as tetraethyl ortho silicate, alcohol solvent, and an acid catalyst. | 2020-04-30 |
20200129662 | ORTHOPEDIC IMPLANT HAVING A CRYSTALLINE GALLIUM-CONTAINING HYDROXYAPATITE COATING AND METHODS FOR MAKING THE SAME - An orthopedic implant having a metal surface and a hydroxyapatite layer comprising gallium ions therein disposed on at least part of the metal surface is described. The hydroxyapatite layer has an average crystallite size of less than about 75 nm in at least one direction and dissolves for more than 2 hours in vitro. The hydroxyapatite layer is substantially free of carbonate. The coating, which is formed on a sodium titanate surface, has increased shear strength and tensile strength. The coating is formed by a solution deposited hydroxyapatite process under inert conditions. The pH of the solution varies by less than 0.1 pH unit/hour during coating formation. | 2020-04-30 |
20200129663 | HOLLOW POROUS SPHERICAL PARTICLE ARTIFICIAL BONE AS WELL AS PREPARATION METHOD AND APPLICATION THEREOF - The disclosure provides a preparation method of a hollow porous spherical particle artificial bone. The method comprises: (1) uniformly mixing bioceramic powder, bioglass powder and an excipient to obtain a solid-phase mixture, then adding binder solution to the solid-phase mixture, and uniformly mixing to obtain a plastic wet material; (2) loading a plastic wet material into an extrusion device of an extrusion rounder to be extruded by the orifice plate of the extrusion device to form a strip-shaped material; (3) putting the strip-shaped material into the spheronization device, cutting, and then spheronizing to form spherical particles; and (4) placing the spherical particles into a furnace, debinding, removing the excipient and the binder, and then sintering at 750-1550° C. | 2020-04-30 |
20200129664 | CHAMBER FOR TRANSPLANTATION AND DEVICE FOR TRANSPLANTATION - According to the present invention, there are provided a chamber for transplantation, including a membrane for immunoisolation at a boundary between an inside and an outside of the chamber for transplantation, in which the membrane for immunoisolation includes a porous membrane, and in the porous membrane, a maximum heat shrinkage ratio among heat shrinkage ratios in a membrane surface direction after immersion in water at 90° C. for 3 hours is 0.00% to 5.00%, and a difference between the maximum heat shrinkage ratio and a minimum heat shrinkage ratio among the heat shrinkage ratios in the membrane surface direction is 0.00% to 1.30%; and a device for transplantation including the chamber for transplantation enclosing a biological constituent therein. The chamber for transplantation of the present invention has a high durability and is capable of maintaining an enclosed biological constituent for a long period of time. | 2020-04-30 |
20200129665 | NOVEL NANOFIBER-BASED GRAFTS AND METHODS OF MAKING AND USING THE SAME - Nanofiber-based biomaterials containing fibroin for wound repair and tissue replacement are provided with methods of making and using the same. | 2020-04-30 |
20200129666 | Variable Density Tissue Graft Composition and Methods of Making and Using the Same - Disclosed are tissue graft compositions made of materials having different densities, methods of making, and methods of treatment for restoring t issues in a patient. | 2020-04-30 |
20200129667 | REGENERATIVE TISSUE AND NATURAL TISSUE IMPLANTS - The present invention is an improved implant made from regenerative tissue or natural tissue, methods of making the implant, and methods of using the implant. | 2020-04-30 |
20200129668 | NON-RESORBABLE BONE ALLOGRAFTS AND METHOD FOR MAKING SAME - A method for producing non-resorbable bone allografts having improved osteoconductivity and biocompatibility in regenerative dental and medical applications as compared with non-resorbable xenografts. The method comprises excising one or more bone allografts from a donor's body; freeze-drying the bone allografts; demineralizing the freeze-dried bone allografts; preserving and sterilizing the bone allografts; and thermal processing of the bone allografts at a temperature greater than about 300 degrees Celsius. | 2020-04-30 |
20200129669 | BIORESORBABLE MAGNESIUM-BASED SPONGE AND FOAM MATERIALS, METHODS AND DEVICES - Provided herein are magnesium-based sponges and foams and methods for surface modification to enhance bioactivity. The magnesium-based sponges and foams may be useful as tissue or bone grafts which promote cellular adhesion and osseointegration and conduction, as well as various other biological functions including, for example, antibacterial properties, hydrophobicity or hydrophilicity and the ability to modulate immune response. The described sponges and foams have precise mechanical properties which are specifically designed for enhanced integration with surrounding tissue. The described magnesium-based materials are bioresorbable, allowing for the gradual, safe absorption of the material when exposed to bodily fluids. | 2020-04-30 |
20200129670 | CONTROLLED RANDOMIZED POROUS STRUCTURES AND METHODS FOR MAKING SAME - Improved randomized porous structures and methods of manufacturing such porous structures are disclosed. The scaffold of the porous structures are formed from by dividing the space between a plurality of spatial coordinates of a defined volume, where the plurality of spatial coordinates have been moved in a random direction and a random finite distance according to a predetermined randomization limit. | 2020-04-30 |
20200129671 | MEDICAL DEVICE COATING WITH A BIOCOMPATIBLE LAYER - Medical devices with a hydrogel layer covalently attached to a portion of the outer surface of the medical device are provided along with methods for applying the coating. The hydrogel layer can include a first polymer species comprising polyethylene glycol (PEG) and a second polymer species. Examples of the second polymer species include PEG and polyacrylamide (PAM). The first and second species can be at least partially cross-linked. Methods for forming the hydrogel coatings on the medical devices are provided including nucleophilic conjugate reactions, such as Click reactions. | 2020-04-30 |
20200129672 | INTRAOCULAR DRUG DELIVERY AND FILTER DEVICE AND METHODS OF USING SAME - The present disclosure provides an implantable device comprising a substrate capable of capturing an intraocular target molecule and to methods of use thereof. | 2020-04-30 |
20200129673 | METHOD FOR PREPARING AN ANTI-ADHESION BARRIER FILM - The present invention relates to a method for preparing a surgical anti-adhesion barrier film comprising the following steps: a°) a first solution, comprising an oxidized collagen is prepared, b) a polyphosphate compound is added to the solution of a) in a quantity so as to obtain a concentration of polyphosphate ranging from 0.007 to 0.7%, by weight, with respect to the total weight of the solution, c) the pH of the solution obtained in b) is adjusted to about 9 by addition of a base or to about 5.1 by addition of an acid, d) a diluted solution is prepared by adding water to solution of c), e) a first layer of solution obtained in c) is casted on an inert support, f) before complete gelation of the layer obtained in d), a second layer, of diluted solution obtained in d) is applied on top of said first layer and let to gelify, g) the gelified first and second layers are dried to obtain a film. The invention further relates to a film obtainable by such a method and to a surgical implant comprising a prosthetic fabric and such a film. | 2020-04-30 |
20200129674 | SHORT RANGE PEER TO PEER NETWORK FOR NEGATIVE PRESSURE WOUND THERAPY DEVICES - The present disclosure relates to a network system. The system is formed by at least two negative pressure wound therapy (NPWT) devices. The first NPWT device includes a wireless radio, user interface, controller, and processing circuit. The wireless radio wirelessly communicates with the second NPWT device. The user interface displays operational status of therapy operation, receives a command of operational change from a user, and displays wireless radio connection strength between the first NPWT device and the NPWT device. The controller controls therapy operation of the first NPWT device based on input from the user interface. The processing circuit causes the wireless radio to communicate with the second NPWT device, determines wireless radio connection strength between the first NPWT device and the second NPWT device based on communication between the first NPWT device and the second NPWT device, and causes the user interface to display determined wireless radio connection strength. | 2020-04-30 |
20200129675 | REDUCED-PRESSURE DRESSING CONNECTION PADS, SYSTEMS, AND METHODS - Systems, methods, and connectors are provided that introduce a working gas at certain times into a reduced-pressure dressing into order to break or avoid vacuum locks in the conduits removing fluids. In one instance, a reduced-pressure connector includes a connector body for applying a reduced pressure to the tissue site. The connector body is formed with a venting port, a body conduit, and a receptacle to receive a reduced-pressure delivery conduit. The reduced-pressure connector includes a flexible member coupled to the connector body over the venting port. The flexible member is formed with at least one venting aperture. The flexible member is biased away from the venting port and is configured to collapse and seal the venting port under a reduced pressure greater than a threshold pressure. Other systems, apparatuses, and methods are disclosed. | 2020-04-30 |
20200129676 | SPECIALIZED SUCTION IRRIGATOR WITH CLOT BUSTING AND ANTI-CLOGGING FEATURES - A laparoscopic anti-clogging device suitable for abdominal surgeries whose main function is to overcome the deficiencies caused by the clogging of a suction tool used in suction irrigation. More specifically an improved suction unclogging means used in. Laparoscopic Suction Irrigator Systems (LSIS) that is used in the removal of bodily fluids, exudate and or bodily materials from the abdomen of a patient, allowing suction of a high-volume fluid in deep cavities and prevents interrupting fluid flow due to tissues clogging the device, and having the ability of being modified intra-abdominally to then focus all of its vacuum force on the distal opening, thereby facilitating blood clot busting and suction of solidified fluids as well as directed irrigation. | 2020-04-30 |
20200129677 | FLUID HANDLING ASSEMBLY AND RELATED TUBE SET AND METHOD FOR USE IN SURGICAL PROCEDURES - A fluid handling system for a surgical procedure includes a console and a tubing set. The console exhibits a peristaltic pump, a pinch valve, one above the other. Two recessed seats are located to the left and right sides of the pump and valve. The tubing set includes an irrigation tube and an aspiration tube each coupled to a pair of magnetic disks disposable in respective ones of the recessed seats. Upon such disposition, the irrigation tube is disposable in operative engagement with the peristaltic pump and the aspiration tube is insertable into a slot of the pinch valve. | 2020-04-30 |
20200129678 | VACUUM DRIVEN SUCTION AND IRRIGATION SYSTEM - A vacuum assisted suction and irrigation system includes a suction and irrigation wand, an irrigation fluid supply, a vacuum source, and a fluid pump. The vacuum source is connected to a suction valve of the suction and irrigation wand to provide suction within the suction and irrigation wand. The irrigation fluid supply is connected to the suction and irrigation wand via the fluid pump to supply pressurized irrigation fluid to the suction and irrigation wand. The vacuum source is connected to the fluid pump to pressurize the irrigation fluid being delivered to the suction and irrigation wand. | 2020-04-30 |
20200129679 | Dual Therapy Device and Related Method - A dual therapy device for delivering reduced pressure therapy and regenerative therapy to a degenerated vertebral disc and a method of using the same is disclosed herein. The dual therapy device is preferably comprised of a cannulated trocar for accessing a disc space, a probe that coils within said disc space and a cannulated and fenestrated catheter that also coils within the disc space, adjacent to the probe. The catheter is useful for applying reduced or negative pressure therapy to the entire or substantially entire disc space and, upon completion of said therapy, delivering regenerative therapy to the disc space in the form of a biological material. Nonetheless, it is also contemplated that the catheter may be eliminated, and the dual therapies delivered via a cannulated and fenestrated probe. | 2020-04-30 |
20200129680 | Bone Marrow Harvesting Needle Improvements - A bone marrow aspiration device and associated method includes an introducer needle assembly and an aspiration needle assembly. The introducer needle assembly includes an introducer cannula having proximal and distal ends, each end including an opening, and a screw assembly coupled to the introducer handle. The screw assembly includes a threaded tube and a lead screw receivable in the threaded tube. An outer cover is disposed around and in sealing engagement with the threaded tube and the lead screw. The aspiration needle assembly is receivable in the introducer cannula and includes an aspiration cannula forming a channel for aspirating bone marrow and including a flexible portion that extends from a distal end along a length of the aspiration cannula. A length of the aspiration cannula that extends beyond the distal end of the introducer cannula is adjustable by advancing the lead screw into or reversing the lead screw out of the threaded tube. | 2020-04-30 |
20200129681 | DEVICE FOR HARVESTING, PROCESSING AND TRANSFERRING ADIPOSE TISSUE - The present disclosure provides devices and methods for harvesting and processing tissue from patients for grafting. The devices can include a tissue collection chamber for ascetically collecting, processing, and/or re-implanting adipose tissue. | 2020-04-30 |
20200129682 | SUPPORTER FOR BODY - A supporter for body ( | 2020-04-30 |
20200129683 | CATHETER DEVICE - The catheter device comprises a drive shaft connected to a motor, and a rotor mounted on the drive shaft at the distal end section. The rotor has a frame structure which is fanned by a screw-like boundary frame and rotor struts extending radially inwards from the boundary frame. The rotor struts are fastened to the drive shaft by their ends opposite the boundary frame. Between the boundary frame and the drive shaft extends an elastic covering. The frame structure is made of an elastic material such that, after forced compression, the rotor unfolds automatically. | 2020-04-30 |
20200129684 | CATHETER DEVICE - The catheter device comprises a drive shaft connected to a motor, and a rotor mounted on the drive shaft at the distal end section. The rotor has a frame structure which is formed by a screw-like boundary frame and rotor struts extending radially inwards from the boundary frame. The rotor struts are fastened to the drive shaft by their ends opposite the boundary frame. Between the boundary frame and the drive shaft extends an elastic covering. The frame structure is made of an elastic material such that, after forced compression, the rotor unfolds automatically. | 2020-04-30 |
20200129685 | INTRA-AORTIC SPIRAL BALLOON PUMP - An intra-aortic balloon pump (IABP) is provided that has a series of spiral pleats that function to control the wash of blood associated with an inflation cycle. Additionally, the torsional expansion increases the net efficiency of the IABP relative to a conventional cylindrically shaped balloon. The inflating membrane is textured to promote natural growth of a biologic lining on the surface of the indwelling pump to reduce the need for anticoagulation and the risk of thromboembolic events; promote washing of the surface to minimize stasis and thrombus formation; minimize strain on the IABP; minimize elongation radially and longitudinally to avoid fatigue of the IABP; minimize stretching and stress distribution along a balloon; promote a sweeping effect through the channels in the non-expanded state to wash the surface; or a combination thereof. | 2020-04-30 |
20200129686 | DUAL RESERVOIR HEMODIALYSIS SYSTEM - A portable hemodialysis system is provided including a dialyzer, a closed loop blood flow path which transports blood from a patient to the dialyzer and back to the patient, and a closed loop dialysate flow path which transports dialysate through the dialyzer. In addition, the hemodialysis system includes two reservoirs which can be alternately placed in the dialysis flow path using various controllable fluid valves. The hemodialysis system may include a sorbent filter in the dialysate flow path which filters used dialysate. Alternatively, the filter may be positioned within a separate closed loop filter flow path which is isolated from the blood flow path and dialysate flow path. For this embodiment, the hemodialysis system includes additional controllable fluid valves which selectively connect the filter flow path to the reservoir which is not currently providing dialysis treatment to a patient. | 2020-04-30 |
20200129687 | OXYGENATOR - An oxygenator apparatus for use in an extracorporeal circuit. The apparatus includes a housing and a membrane assembly disposed within the housing. The membrane assembly includes a first plurality of gas exchange elements disposed in a first zone and a second plurality of gas exchange elements disposed in a second zone. The second zone is arranged concentrically around the first zone. The first and second plurality of gas exchange elements are fluidly open along a body and fluidly separated along a distal end. The first zone is configured to be fluidly coupled to an oxygen source and the second zone is configured to be fluidly coupled to a negative pressure source. A blood flow path includes a generally radial flow through the first zone to add oxygen to the blood and the second zone to separate gaseous micro emboli from the blood through the plurality of gas exchange elements. | 2020-04-30 |
20200129688 | BLOOD FILTER - Provided is a blood filter that resists deterioration in properties as a result of electron beam sterilization treatment performed before or during use as a blood filter, has durability, dimensional stability, and chemical resistance at excellent levels, also has biocompatibility, and resists deterioration in properties even upon the electron beam sterilization treatment. The blood filter according to the present invention includes a nonwoven fabric made of PEEK fibers. Preferably, the blood filter according to the present invention has an average pore size of 3 to 280 μm and has a porosity of 15% to 70%; and the PEEK fibers have an average fiber diameter of 10 μm or less. | 2020-04-30 |
20200129689 | Interface Device For Performing Hemodialysis - Interface device between a hemodialysis machine and venous and arterial tubes, this interface device comprising: a first port adapted to be connected to an output port of the hemodialysis machine; a venous port to inject blood into the venous tube; said interface device comprises: a second port adapted to be connected to an input port of the hemodialysis machine; an arterial port for receiving blood from the patient from the arterial tube, the interface device being further adapted to selectively allow or prohibit the passage of blood between the first and second ports and the venous and arterial ports respectively. | 2020-04-30 |
20200129690 | Bolus Delivery Device - A bolus delivery device is provided that comprises a housing and a reservoir defined by an activation dome and a reservoir seat and disposed within the housing for receipt of a volume of a fluid. The bolus delivery device further comprises a bladder disposed in the housing that is in fluid communication with the reservoir for receipt of the fluid from the reservoir; an actuator; an inlet conduit in fluid communication with the reservoir for providing the fluid to the reservoir; and an outlet conduit in fluid communication with the bladder for providing the fluid to a patient. The actuator is in operative communication with the reservoir to initiate a flow of the fluid from the reservoir to the bladder. The bladder expands as the bladder receives the fluid and contracts as the bladder dispenses the fluid. An infusion assembly including a bolus delivery device also is provided. | 2020-04-30 |
20200129691 | HOUSING ARRANGEMENTS FOR INFUSION PUMPS - An infusion pump, including a housing, a user interface, a motor and a set of drive components, and a controller. The housing enables selective stacked attachment with other infusion pumps. The housing includes a top portion with a handle integrated into an outer surface that partially defines a generally U-shaped retaining feature. The housing also includes a bottom portion with a generally U-shaped projection that is contoured to selectively mate with the retaining feature of another infusion pump. The user interface provides a front side to the housing that receives commands regarding infusion pump operation. The motor and set of drive components are at least partially located within the housing and mechanically direct infusion of infusate. The controller is located within the housing and that controls operation of the motor and the set of drive components. | 2020-04-30 |
20200129692 | LIQUID MEDICINE INJECTION DEVICE - The present invention discloses a liquid medicine injection device that is attached to a patient's body to inject liquid medicine such as insulin at an appropriate time. | 2020-04-30 |
20200129693 | MEDICAL FLUID THERAPY SYSTEM HAVING MULTI-STATE ALARM FEATURE - A medical fluid therapy system having a multi-state alarm feature is disclosed. An example medical fluid therapy system includes a pumping apparatus configured to pump a medical fluid from a fluid container. The example system also includes a processor configured to generate a first alarm signal associated with a first low level event of the medical fluid in the fluid container, generate a second alarm signal associated with a second low level event of the medical fluid in the fluid container, and receive an activation of a snooze element for deactivating the first alarm signal after the first low level event has occurred and enabling the second alarm signal to be activated upon occurrence of the second low level event. The system further includes a server configured to receive and route at least one of the first alarm signal or the second alarm signal for display at a user device. | 2020-04-30 |
20200129694 | BLOCKCHAIN CONSENSUS NODE SELECTION - Techniques are described selecting consensus nodes in a blockchain. A voting process is performed by a plurality of shareholder nodes to generate a voting result for each shareholder node. The voting process comprises each shareholder node voting for a plurality of expected nodes, and the expected nodes and the plurality of shareholder nodes comprise a group of nodes associated with a blockchain. A shareholder node is a node that owns at least one share. A voting result is verified for each shareholder node. After the voting process, a number of shares owned by each node of the group of nodes id determined based on the voting result. A plurality of consensus nodes are selected from shareholder nodes based on the number of shares owned by each of the shareholder nodes | 2020-04-30 |
20200129695 | ACTUATOR AND DEVICE FOR SYNCHRONIZED INJECTION AND ASPIRATION - An actuator for synchronized injection and aspiration, comprising: a first rod, having a length equal to an inner length between a head of a first plunger of a first standard-size syringe and a seal of the first plunger, and having a width smaller than a gap created between the first plunger and a barrel of the first standard-size syringe; a second rod, having a length equal to an inner length between a head of a second plunger of a second standard-size syringe and a seal of the second plunger, and having a width smaller than a gap created between the second plunger and a barrel of the second standard-size syringe; a flexible connector mechanically attached to a distal end of the first rod at a first end and to a distal end of the second rod at a second end. | 2020-04-30 |
20200129696 | TRANSPORT ASSEMBLY FOR A MEDICAMENT DELIVERY DEVICE AND A MEDICAMENT DELIVERY DEVICE COMPRISING THE SAME - A transport assembly for shipping components of a medicament delivery device to final assembly is presented, where the transport assembly has a plunger rod, a first resilient member configured to bias the plunger rod, an elongated plunger rod holder configured to receive the plunger rod, a transport securing sleeve configured to receive a portion of the plunger rod holder, and configured to move axially from a first position relative to the plunger rod holder in which the transport securing sleeve prevents the plunger rod holder to disengage from the plunger rod to a second position located distally relative to the first position, enabling disengagement of the plunger rod holder from the plunger rod, a rear end cap, and a second resilient member configured to bear against the rear end cap and configured to bias the transport securing sleeve in the proximal direction away from the second position. | 2020-04-30 |
20200129697 | MEDICAMENT DELIVERY DEVICE HAVING AN ACTIVATING MECHANISM - The disclosure relates to medicament delivery device including an activating mechanism, wherein the activating mechanism includes a hollow injection needle, a cartridge containing a dosage of a medicament, a cartridge carrier including at least one resilient arm for holding the cartridge, a removable needle cap for covering the injection needle, and a drive element adapted to couple with the cartridge, wherein the cartridge is retained in a position spaced apart from the injection needle in a proximal direction (P) by the at least one resilient arm when the medicament delivery device is in an initial position (P | 2020-04-30 |
20200129698 | Injector Devices - An injector device comprises a needle support member for supporting a distal end of a needle within a collar region of the device. On insertion of the neck of a drug cartridge into the collar region, the tip of the needle pierces a septum in the drug cartridge and is thereafter supported by the septum. The needle support member is then displaced by the drug cartridge as it moves further into the collar region. The displacement may comprise hinging or sliding of the support member. By supporting the needle as it pierces the septum and by providing controlled resistance to rapid or violent insertion of the drug cartridge, the needle support member enables a single, fine needle to be used for both the distal end and the proximal end without buckling, even if the needle is curved so that the two ends are mutually inclined. | 2020-04-30 |
20200129699 | ACTIVATING MECHANISM FOR A MEDICAMENT DELIVERY DEVICE AND MEDICAMENT DELIVERY DEVICE - The disclosure relates to an activating mechanism for a medicament delivery device, comprising an outer body, a cartridge containing a dosage of a medicament and sealed with a sealing element that is arranged across an open distal end of the cartridge, a cartridge carrier adapted to hold the cartridge, a needle safety mechanism adapted to hold a double-ended hollow needle and to relatively move along a longitudinal axis with respect to the cartridge and to the outer body to cover or to expose the needle, wherein in an initial position of the medicament delivery device, the double-ended hollow needle is spaced from the cartridge in a distal direction, and wherein when the needle safety mechanism is pressed into the outer body, a proximal end of the needle pierces the sealing element. The disclosure further relates to a medicament delivery device comprising such an activating mechanism. | 2020-04-30 |
20200129700 | Methods For Injecting Fluids - The invention relates to an instrument head, comprising: an exit opening ( | 2020-04-30 |
20200129701 | HARVESTING ENERGY FROM OPERATION OF A SYRINGE - Various methods and apparatus disclosed herein relate to apparatus and techniques for harvesting energy from operation of a syringe, and utilizing that energy for various purposes. In various embodiments, a method ( | 2020-04-30 |
20200129702 | DOSE CAPTURING ASSEMBLY WITH SECONDARY IMAGE ANALYSIS FEATURE - An add-on device for a drug delivery device comprises a camera for capturing an image of a scale drum, and a processor for determining the value of a captured image using a first image analysis process, the value corresponding to a set dose amount. If the determined value belongs to a pre-defined group of values, the determined value is confirmed using a second image analysis process in which for a given value from the pre-defined group of values one or more partial image areas and an associated nominal content thereof are pre-defined. If the captured content for each image area corresponds to the nominal content, the determined value is confirmed. | 2020-04-30 |
20200129703 | Leak-Free Stopper Having Low Breakloose and Sustaining Forces - A thermoplastic elastomer stopper that meets the desired material properties of a stopper for a syringe assembly is disclosed. The compression set of the thermoplastic elastomer stopper of the present disclosure is ≤50% when measured at 25% compression for 22 hrs at 70 degree C. The hardness of the thermoplastic elastomer stopper of the present disclosure is 40-70 Shore A. The viscosity of a thermoplastic elastomer stopper of the present disclosure is ≥70 Pa·s at 1,000 s | 2020-04-30 |
20200129704 | DRUG DELIVERY DEVICE FOR DELIVERY OF A MEDICAMENT - Various embodiments of drug delivery devices and methods of assembling such devices are provided. In one embodiment, a drug delivery device for dispensing medicament comprises a medicament cartridge, wherein the cartridge comprises (i) a distal end, (ii) a proximal end that is opposite the distal end along a body axis of the cartridge, and (iii) a movable piston arranged substantially at the proximate end of the cartridge. The drug delivery device further comprises a piston rod having a distal end for axially moving the piston in the distal direction during dispensing of a set dose of medicament, wherein a relative axial distance between the distal end of the piston rod and a proximal face of the piston is set during assembly of the drug delivery system. The relative axial position between may be set such that the piston rod and the proximal face of the piston abut each other. | 2020-04-30 |
20200129705 | Injection Pen - An injection pen comprises a starting mechanism ( | 2020-04-30 |
20200129706 | Needle Protection Assembly - The application relates to a needle protection assembly ( | 2020-04-30 |
20200129707 | Pre-filled Safety Needle and Syringe System - A needle and pre-filled syringe system that provides ultra-low dosage waste and automatic needlestick protection. A syringe assembly is pre-filled with an injection material. A needle head assembly attaches to the syringe assembly. A spacer is disposed between the needle head assembly and the syringe assembly. The spacer has a central opening. The needle head assembly supports a needle with a needle base. When assembled, the needle base passed into the central opening of the spacer. The needle head assembly also contains a safety slide that can selectively cover the needle. During an injection, pressure and/or contact with the plunger head causes the spacer to contact and move the safety slide. The safety slide moves to cover the needle during the injection procedure, therein rendering the needle safe before the injection process is even complete. | 2020-04-30 |
20200129708 | Ultra-Low Waste Needle and Syringe System that Automatically and Passively Renders a Needle Safe During the Injection Process - A needle and syringe system that provides ultra-low dosage waste and automatic needlestick protection. A syringe assembly is provided that contains a barrel and a plunger. A tubular spacer is disposed in the barrel. A needle head assembly is provided that includes a collar and a needle. A safety slide is positioned between the needle and the collar. The safety slide has a sheathing tube that surrounds part of the needle. The safety slide can move relative the needle. In a first position, the sheathing tube does not extend beyond the sharpened end of the needle. In a second position, the sheathing tube extends beyond the sharpened end of the needle. When advanced, the plunger head moves the tubular spacer. The tubular spacer passes over the base of the needle and presses against the safety slide. The safety slide is moved from the first position to the second position. | 2020-04-30 |
20200129709 | WEARABLE INSPIRATION SYNCHRONIC ULTRASONIC NEBULIZER-HUMIDIFIER DEVICE - A wearable inspiration synchronic ultrasonic nebulizer-humidifier device is presented. The headset coupled nebulizer logic electrically connected to nebulizer controlling nebulizer crystal oscillation and breathing signal. Nebulizer housing is firmly attached to distal end of flexible tubing for flowing liquid from the liquid reservoir ampoule to the nebulizer housing containing nebulizer a piezoelectric crystal with electrical coupling to nebulizer control logic, fluid compartment, jet and aerosol nozzle for inspiration-expiration spray providing users wearing a portable humidifier-nebulizer device to adjust nostril aerosol for synchronous inhalation, nozzle position and spray angle. | 2020-04-30 |
20200129710 | CARTRIDGE AND ATOMIZER HAVING SAME - A cartridge and an atomizer having the cartridge are disclosed, the cartridge includes a micro-porous body with an absorption surface and an atomization surface; a heating element embedded in the micro-porous body; the heating element disposed between the absorption surface and the atomization surface; the heating element includes a first surface and a second surface; the heating element is bored with multiple spaced through holes, the through holes are extending from the first surface to the second surface. | 2020-04-30 |
20200129711 | INHALERS AND AIRFLOW ADAPTORS THEREFOR - The present disclosure describes an inhaler for the inhalation of powder medication. The inhaler has a body and at least one reservoir containing powder medication, the body having an air inlet and an outlet for the transmission to a patient of air entering the body through the air inlet and powder medication. The outlet has a total cross-sectional area for flow which is more than 80% of the total cross-sectional area of the air inlet. | 2020-04-30 |
20200129712 | INHALER AND METHODS OF USING AND MAKING THE SAME - A dose ring for a dry powder inhaler (DPI) device includes an aluminum foil member covering particulate medication cavities and through holes. The device includes hinged flaps formed by a cut so that one radial side is uncut and forms a hinge. Each flap can cover both a cavity for particulate medication and a through hole located between that cavity and the circular inside edge of the dose ring. | 2020-04-30 |
20200129713 | Gas Flow Indicator Device - A gas flow indicator device has a housing defining a chamber. An annular indicator extends over the chamber enabling gas to enter along a bore and is spaced from an inner surface, defining an annular space. A moveable concealment member has an annular skirt receivable into the annular space so one end provides a seal against an annular surface at an end wall while a transverse wall at the other end defines an opening providing resistance to gas flow. The skirt can be held in sealing engagement at the annular surface to conceal the indicator through a window. Increasing gas flow rate overcomes the bias of a biasing member and moves the concealment member to expose the indicator and provide a visual indication of gas flow. A fitting member has an engagement portion operable to constrain the biasing member to preclude vibrations and/or prevent its full compression. | 2020-04-30 |
20200129714 | METHODS AND SYSTEMS FOR ADAPTIVE BASE FLOW - This disclosure describes systems and methods for providing novel adaptive base flow scheduling during ventilation of a patient to optimize the accuracy of estimated exhaled tidal volume. Further, this disclosure describes systems and methods for providing novel adaptive inspiratory trigger threshold scheduling during the novel adaptive base flow scheduling. | 2020-04-30 |
20200129715 | RESPIRATORY APPARATUS - A head-mountable flow generator is configured to deliver a flow of breathable gas at a continuously positive pressure with respect to ambient air pressure to a patient interface in communication with an entrance to a patient's airways including at least an entrance of the patient's nares, while the patient is sleeping, to ameliorate sleep disordered breathing. The flow generator includes a motor, an impeller assembly and housing that encases the motor and the impeller assembly. The housing is configured to be mounted on the patient's head and comprises an inlet to receive the flow of breathable gas and a pair of opposing outlets to deliver the flow of breathable gas. In addition, the impeller assembly is configured to pressurize the flow of breathable gas received from the inlet, and the housing is configured to convey the pressurized flow of breathable gas through both outlets. | 2020-04-30 |
20200129716 | DELIVERY TUBE AND METHODS FOR TRANSPORTING PARTICLES INTO THE RESPIRATORY SYSTEM - Apparatus for transporting particles through a patient's trachea into the respiratory system include a delivery tube having at least a ventilation lumen and a particle delivery lumen. The delivery tube has a centering device near its distal tip, such as a balloon eccentrically mounted on the tube to position an outlet of the particle delivery lumen near a centerline of the trachea above the carina branching into the right and left bronchus. A proximal end of the delivery tube connects to a source of particles, and a controller may be provided to adjust a rate and/or an amount of the particles delivered to the patient. In a specific example, frozen particles are delivered to control core body temperature. In other instances, the particle may be a medicament or other substance for effecting other therapies or diagnostic procedures. | 2020-04-30 |
20200129717 | METHOD AND APPARATUS FOR CLEANING A TUBE - An umbrella-like scraper for cleaning tubes and pipes may include a scraper, an actuator and a hinge configured for selective deployment of the scraper by manipulation of the actuator. | 2020-04-30 |
20200129718 | RESUSCITATION AND VENTILATION MASK - A mask for the delivery of a medical gas under positive pressure. The engagement surface is generally circular in shape and is sufficiently rigid that operatively, when a suitable retention force is applied to the mask, an effective seal is produced at the interface of the engagement surface and the surrounding tissue primarily by deformation of the surrounding tissue. | 2020-04-30 |
20200129719 | APPARATUS AND METHOD FOR OXYGEN DELIVERY TO A PATIENT DURING MANUAL VENTILATION - A system for detecting manual ventilation and selectively delivering a high flow of oxygen. The system comprises a source of compressed oxygen coupled to a first lumen of a nasal cannula, with an oxygen flow control valve coupled to a processor to control the flow of oxygen to the nasal cannula. A second lumen of the nasal cannula is in connection with a pressure sensor and the pressure sensor in connection with the processor. The processor may receive the pressure values and be programmed to determine when manual ventilation has occurred, and send a signal to the oxygen flow control valve to send a high flow of oxygen in response to manual ventilation. | 2020-04-30 |
20200129720 | AUTOMATICALLY ADJUSTING HEADGEAR FOR PATIENT INTERFACE - A headgear for securing a mask to a user's face is described. The headgear requires a first load force to elongate the headgear and, when fitted to a user, applies a balanced fit force that substantially equals a load force applied to the headgear during respiratory therapy. In some embodiments, the headgear includes an elastic portion configured to provide a retraction force, a non-elastic portion configured to be inelastic in comparison to the elastic portion, and a restriction mechanism connected to the non-elastic portion and to the elastic portion. The restriction mechanism is configured to apply a first resistance force to the user's head on elongation of the headgear and a second resistance force to the user's head on retraction of the headgear. | 2020-04-30 |
20200129721 | TRANSFER UNIT, VENTILATOR, VENTILATION SYSTEM, PROCESS FOR CHANGING A VENTILATOR USED FOR A VENTILATION PROCESS OF A PATIENT - A transfer unit ( | 2020-04-30 |
20200129722 | OUTLET CONNECTION ASSEMBLY AND METHOD OF MAKING THE SAME - A connection assembly for a respiratory therapy system, comprising: an outlet assembly, said outlet assembly including an outlet housing and a swivelling disc located on said outlet housing, said outlet housing and said swivelling disc defining, at least in part, a recess; an outlet connector located at an end of a tube portion, said outlet connector including an electrical connector; and a cable having a first end to connect to the electrical connector and a second end to connect to at least one electrical component of the respiratory therapy system, said cable having a slack portion, wherein said outlet connector and said swivelling disc are rotatable in unison between a first position and a second position, and wherein the slack portion of the cable extends from the recess and wraps around the swivelling disc as the swivelling disc is rotated from the first position to the second position. | 2020-04-30 |
20200129723 | SELF-SEALING T-PIECE AND VALVED T-PIECE - Apparatus ( | 2020-04-30 |
20200129724 | CONDUIT CONNECTOR ASSEMBLY OF A PATIENT INTERFACE, AN ANTI-ASPHYXIA VALVE FOR A CONDUIT CONNECTOR ASSEMBLY AND A CONNECTOR - A conduit connector assembly is provided for a respiratory therapy apparatus and configured to connect a patient interface to a gas delivery conduit. The assembly comprises: a conduit comprising a first flow port configured to be connected to the patient interface, and a second flow port configured to be connected to the gas delivery conduit, and a supplementary flow port; and a first valve port configured to be closed or opened by a valve flap. The conduit and the valve flap selectively provide an inspiratory flow path from the second flow port of the conduit to the first flow port of the conduit; and an expiratory flow path from the first flow port of the conduit to the supplementary flow port via the first valve port. A supplementary gas flow path is provided between the first and/or second flow ports and the supplementary flow port via a supplementary valve port. | 2020-04-30 |