18th week of 2015 patent applcation highlights part 56 |
Patent application number | Title | Published |
20150119196 | METHOD FOR OPERATING A DRIVETRAIN OF A MOTOR VEHICLE HAVING A FREE-WHEELING ENGINE-OFF FUNCTION, CONTROL DEVICE AND MOTOR VEHICLE - A method for operating a drive train of a motor vehicle with an internal combustion engine, automatic transmission and at least one drive axle, is disclosed wherein in order to save fuel during the driving mode when the accelerator pedal is not activated a clutch device which is associated with the automatic transmission is opened and subsequently the internal combustion engine is shut down. When the accelerator pedal is activated again the internal combustion engine is started and in the automatic transmission the highest possible gear speed for the reconnection is firstly selected and so that the revving up time of the engine rotational speed is as short as possible, with the result that the necessary drive torque which is generated by the internal combustion engine can be made available at the drive axle as quickly as possible. | 2015-04-30 |
20150119197 | PORTABLE SENSING MODULE FOR A FITNESS EQUIPMENT AND A DATA TRANSMISSION PROCESS FOR USING THE PORTABLE SENSING MODULE - A portable sensing module for a fitness equipment includes a sensing unit, a center control unit, a storage unit, a wireless transceiver and a connecting unit and is capable of collecting static data of the fitness equipment and dynamic data indicating the status of the user. The sensing module connects the fitness equipment to follower equipments in a wire or wireless manner, thus expanding the function of the fitness equipments. A data transmission process includes: using the sensing unit to detect the status of the fitness equipment; transmitting the data to the center control unit and converting it into computable data, then computing; comparing the data with the data sheets stored in the storage unit and then encoding it into codes usable by the follower equipments; packaging the codes into usable information; and using the connecting unit and the wireless transceiver to transmit the data to the follower equipments. | 2015-04-30 |
20150119198 | SYSTEM AND METHOD FOR PROVIDING A TRAINING LOAD SCHEDULE FOR PEAK PERFORMANCE POSITIONING - A system for providing a training load schedule for peak performance positioning includes an apparatus for providing a training load schedule for peak performance positioning. The apparatus includes an initial load schedule module that provides an initial load schedule. The apparatus also includes a fatigue level module that detects a fatigue level. In addition, the apparatus includes a dynamic load schedule module that creates and updates a dynamic load schedule by modifying the initial load schedule based on the fatigue level. | 2015-04-30 |
20150119199 | ROPE CLAMP SYSTEM - Rope clamps and methods for attaching rope clamps to climbing structures are provided. Rope clamps illustratively comprises a clamp portion configured to be attached to a climbing structure, wherein the clamp portion comprises a clamp body, a cover, a rope path and a fastener. The clamp body is configured to engage a portion of the climbing structure. The cover is configured to engage with a front of the clamp body. The rope path extends between the clamp body and the cover. The fastener is configured to attach the cover to the clamp body. Further, at least one rope configured to enter the rope path at a first point, extend through the rope path and exit the rope path at a second point. | 2015-04-30 |
20150119200 | GLOVE - A glove including a dorsal panel having a finger region. The dorsal panel includes an array of four finger regions and each finger region having at least two weights coupled thereto in a longitudinally spaced relationship to each other. The dorsal panel includes a thumb region spaced and orientated away from the finger region. The thumb region includes a weight coupled thereto. The glove includes a weight coupled to the finger region of the dorsal panel. The weight includes a sealed pocket having heavy grains. The weight is not selectably removable. The glove includes a palmar panel coupled to the dorsal panel and thereby forming a cavity therebetween. The palmar panel includes a slick surface. | 2015-04-30 |
20150119201 | ELLIPTICAL EXERCISE MACHINE WITH ADJUSTABLE STRIDE LENGTH - An elliptical exercise machine with adjustable stride length includes a frame, a driving unit, an adjustment unit, and a coupling unit. The driving unit includes two pedals, a pair of handlebars and a pair of wheels. The handlebars and the wheels are correspondingly and respectively mounted to the frame. A crank is interposed between the wheels. Two pedal shafts are pivotally and respectively mounted between each wheel and each handlebar. The adjustment unit includes a stationery member mounted to the frame, a driving member mounted to the stationery member, and a linearly movable coupling member. The coupling unit includes two first shafts pivotally connected to the coupling member, two second shafts respectively and pivotally mounted between each handlebar and each first shaft. Two bars are pivotally and respectively engaged to each second shaft and the crank. Thereby, a stride length of the two pedals can be simultaneously adjusted. | 2015-04-30 |
20150119202 | EXERCISE DEVICE WITH BRAKING SYSTEM - A selectively inclining hiking exercise apparatus supports a user ambulating thereon. The selectively inclining hiking exercise apparatus includes a support base and a treadbase that selectively inclines with respect to the support base. The treadbase includes a motor for driving an endless belt upon which the user ambulates. The treadbase also includes a magnetic braking assembly for regulating the speed of the endless belt to prevent the endless belt from moving at a rate that is faster than the rate at which the treadbase motor is driving the endless belt. The magnetic braking assembly includes a magnet that selectively moves relative to the treadbase flywheel along a threaded lead screw to provide the braking force. | 2015-04-30 |
20150119203 | DYNAMIC FIT UNIT - An optimal bicycle frame size based on operational characteristics provided by a rider when riding a dynamic fit unit is determined. A best-fit bicycle frame size that is a closest match to the optimal frame size is determined. At least one of the optimal X,Y location of the bicycle's handlebar relative to the bottom bracket, and the optimal X,Y location of the bicycle's seat relative to the bottom bracket, is determined. A stem and spacer from a list of available stems and spacers that will best fit between the head tube of the best-fit frame and the optimal X,Y location of the handlebar is determined. A seat post from a list of available seat posts that will best fit between the seat tube of the best-fit frame and the optimal X,Y location of the seat is determined. A list of the best-fit frame, the best fit stem and spacer, and the best fit seat post, is produced. | 2015-04-30 |
20150119204 | Ski Exersize Apparatus - A foot pad for a ski exercise apparatus has a heel retainer plate across a width of the foot pad proximate one end of a length of the foot pad, the heel retainer plate spaced above a floor level of the foot pad, and a toe stop spanning the width of the foot pad and adjustable along a portion of the length of the foot pad at a forward end of the foot pad opposite the heel retainer plate. A skier, wearing a ski boot, is enabled to step into the foot pad, engage a portion of the sole at the heel of the ski boot under the heel retainer plate, constraining the heel of the ski boot vertically, and to lower a toe of the ski boot to lie behind the toe stop, constraining the toe portion horizontally not vertically. The foot pad is provided with ski exercising apparatus. | 2015-04-30 |
20150119205 | Dorsiflexion apparatus - An apparatus comprising a base, support and resistive band to provide consumers a method for conditioning, preventing or rehabilitating injuries from running, sports and fitness activities. | 2015-04-30 |
20150119206 | EXERCISE JUMP ROPE - Apparatus and methods for an exercise jump rope are disclosed herein. According to one aspect, the exercise jump rope comprises a cable assembly including a cable, a first and a second end attachment at a first end and a second end of the cable, respectively, and a first and a second cable connector coupled to the first and the second end attachment, respectively. The exercise jump rope further comprises a first and a second handle assembly coupled to the first and the second cable connector, respectively, each handle assembly including a hollow handle and a swivel assembly, each swivel assembly including a bearing fixed to the hollow handle, an axis pin having a head and a cross-hole and rotatably coupled to the bearing, an axis pin positioner configured to position a majority of the axis pin within the hollow handle. | 2015-04-30 |
20150119207 | MARTIAL ART TRAINING TOOL THAT EMITS LIGHT WHEN HIT - The present invention relates to a martial art training tool that emits when hit. The martial art training tool includes a light emitting sensor module which is detachably mounted therein and emits light in response to a punch or kick applied to a training body manufactured for martial art training. | 2015-04-30 |
20150119208 | SYSTEM FOR CONVERTING A WATER BOTTLE INTO AN ERGONOMICALLY CORRECT FREE WEIGHT AND PROCESS FOR DOING THE SAME - A conversion system can be used for converting a water bottle into an ergonomically correct free weight. The conversion system includes an upper loop that is configured to encircle the water bottle. A handle portion is joined to the upper loop and configured to accommodate a palm of hand and human fingers against the water bottle and a thumb outside of the handle portion. A lower loop is configured to encircle the water bottle. Accommodating the thumb outside of the handle portion prevents stress on an abductor pollicis brevis muscle, an abductor pollicis longus muscle, an abductor pollicis muscle and a dorsal interosseous muscle that is proximate the thumb while permitting movement of the water bottle by the over-hand grip. | 2015-04-30 |
20150119209 | Exercise Device - In general, an exercise device includes a handle having a first end and a second end. A curved member is coupled to the first end of the handle. A movable member is coupled to the curved member, with the movable member configured to travel along a length of the curved member, where the movable member has a first portion and a second portion, and the second portion is configured to move relative to the first portion. An elongate member has a first end and a second end, and the first end of the elongate member is coupled to the second portion of the movable member. A weight is coupled to the second end of the elongate member. | 2015-04-30 |
20150119210 | SAFETY DEVICE FOR LIFTING AND SUPPORTING BARBELLS - The present invention is a safety device and method of use that comprises a generally round eccentric disk having a peripheral edge and central rotation axis. The generally round eccentric disk has a barbell access slot extending from the peripheral edge to a seat. A cam lobe is formed with a support base adjacent the cam lobe and opposite the central rotation axis from the barbell access slot. The distance is from the peripheral edge adjacent the slot to the seat is greater than the radius of the barbell weights. Rolling the peripheral edge to orient the cam lobe beneath the seat lifts the barbell above the ground. | 2015-04-30 |
20150119211 | Batter Assist Power Trainer Device called a WIND TRAINER - A practice device for use with a bat in batting sports to instruct a batter on proper swing technique and form. It is a batter assist power trainer for sports exercise. This relates to an exercise method and apparatus for improving performance in sports that include swinging of a device such as a bat. It is a batter assist power trainer device made of an airtight airfoil structure made of flexible and durable material and a method or way for connecting the structure to a bat so that the batter assist power trainer device permits a batter to power train and to controllably increase hitting strength which allows the batter to achieve longer hits of a ball for baseball and/or softball. Other configurations include structures made with end sections, with reinforcing splines; and a various ways to connect the device to the bat. | 2015-04-30 |
20150119212 | Exercise Bar - An exercise bar having five linear segments wherein the segments are in bent relationship to each other that allow the user to accomplish a twist-like motion. The bar is symmetrical about a central vertical axis. The first and fifth segments of the bar are the hand-grips. The second and fourth segments each have a first end and a second end and connects to the hand grips at an angle of approximately 120 degrees to about 160 degrees at their first end. The second and fourth segments are attached at their second end to a central third segment which comprises an approximately a neck bar that is curved to fit the neck in an ergonomic fashion. | 2015-04-30 |
20150119213 | REMOVABLE SHOULDER STOP ASSEMBLY WITH LOCKING MECHANISM - A removable locking shoulder stop assembly for use on a reformer exercise apparatus is disclosed that includes a flat rectangular lock plate fastenable to the platform adjacent the head rest on the carriage platform. The lock plate has a first locating member and a keyway spaced from the first locating member. An L-shaped shoulder stop bracket has a second locating member configured to mate with the first locating member of the lock plate. An elongated locking handle assembly is connected to the mounting portion of the bracket and spaced apart from the second locating member. The handle assembly aligns with the keyway when the first locating member is mated with the second locating member and is operable to clamp the shoulder stop bracket to the lock plate when the locating members are mated and the locking handle assembly is hand tightened against the mounting portion of the shoulder stop bracket. | 2015-04-30 |
20150119214 | FASTENING DEVICE, ROBOT SYSTEM, AND FASTENING METHOD FOR FASTENING PLURALITY OF FASTENING MEMBERS - A fastening device enabling a plurality of fastening tools to be arranged at a plurality of fastening locations quickly. The fastening device includes a plurality of fastening tools, a movement mechanism for making the plurality of fastening tools move relative to each other, an imaging part imaging of a plurality of fastening locations, a fastening position calculating part calculating the positions of a plurality of fastening locations based on the image data, and a movement controller control the movement mechanism so as to make at least one fastening tool move so that the individual fastening tools are arranged at positions enabling the fastening members to be fastened to the corresponding fastening locations, based on the calculated plurality of fastening locations. | 2015-04-30 |
20150119215 | SINGLE POWER TOOL CHANGING DEVICE OF CNC MACHINING CENTER - A single power tool changing device of a CNC machining center includes a tool magazine unit, a cam-based tool changing unit, and a power clutch unit. The tool magazine unit includes a tool magazine body, a rotatable disk, and a plurality of tool sets. The cam-based tool changing unit includes a tool change base, a cam mechanism, and a tool changing mechanism. The power clutch unit includes a first force output axle that drives the tool magazine unit to operate, a second force output axle that drives the cam-based tool changing unit to operate, and a power mechanism, which selectively transmits power to the first or second force output axle. As such, the present invention allows for performance of both operations of tool selection and tool change with a single driving power source so as to achieve an advantage of reducing installation cost. | 2015-04-30 |
20150119216 | Container Sizing Method and System - A carton sizing system ( | 2015-04-30 |
20150119217 | SYSTEMS WITH FILM SPEED CONTROL AND RELATED DEVICES, METHODS AND COMPUTER PROGRAM PRODUCTS - Methods, computer program products and apparatus for producing encased products using a sensor assembly that generates a signal associated with when additional sealed casing is needed based on a tautness of the sealed film proximate the sensor assembly and directs at least one servomotor to increase film-drive speed. The increase may optionally be for a short time of less than one second in response to a detected need for additional sealed casing to thereby temporarily increase casing production speed and avoid a need for an excess amount of tubular casing in a buffer. | 2015-04-30 |
20150119218 | SYSTEMS WITH PRE-HEATERS FOR PRODUCING SEAMED ENCASED PRODUCTS AND RELATED DEVICES, METHODS AND COMPUTER PROGRAM PRODUCTS - Methods, computer program products and apparatus for producing encased products using one or more pre-heaters residing proximate to but downstream of a heat-seal heater to pre-heat at least one long edge portion of a casing, typically the long edge portion associated with a lower layer of a joint to be sealed. | 2015-04-30 |
20150119219 | METHOD OF MANUFACTURING AN ABSORBENT ARTICLE HAVING FULLY ENCIRCLING BODYSIDE AND GARMENT-SIDE WAISTBAND - A method for manufacturing absorbent articles comprises delivering a continuous web assembly including a backsheet material, a liquid permeable bodyside liner material, and an absorbent structure interposed between the backsheet material and the bodyside liner material, the web assembly having a body-facing side and a garment-facing side; attaching a discrete segment of first waist elastic material to the body-facing side of the web assembly; attaching a discrete segment of second waist elastic material to the garment-facing side of the web assembly such that the web assembly is interposed between the discrete segments of first and second waist elastic materials; and cutting the web assembly to form a plurality of absorbent articles. | 2015-04-30 |
20150119220 | METHOD AND MACHINE FOR MAKING INTERMEDIATE COMPONENT OF SINGLE USE CAPSULES FOR BEVERAGES - A method for making an intermediate component ( | 2015-04-30 |
20150119221 | APPARATUS AND METHOD FOR FORMING A BENDING CREASE IN CORRUGATED PAPERBOARD - An apparatus for forming a bending crease in corrugated paperboard includes a circumferential portion of a wheel. The circumferential portion has a width and a peripheral surface positioned to compressively rollably receive a corrugated paperboard between the surface of the wheel and a support surface. The circumferential portion includes a protrusion extending radially outward from the circumferential portion greater than 0.070 inch. The protrusion extends radially outward from a base to a tip opposite the peripheral surface, the tip having a width less than the width of the base. The protrusion is configured to form a crease in the corrugated paperboard, the crease having sufficient depth and a width less than or equal to the width of the base, thereby resulting in a bend line formed in the corrugated paperboard that is substantially coincident with the formed crease. | 2015-04-30 |
20150119222 | SHEET FOLDING APPARATUS | 2015-04-30 |
20150119223 | SHEET FOLDING APPARATUS AND SHEET POST-PROCESSING APPARATUS - A sheet folding apparatus having two-folding rollers each of whose outer diameter gradually decreases from the central part to each end part, a folding plate which can move forward to or backward from a nip between the two-folding rollers, and has a cutout part located at an edge part of the folding plate facing the nip between central parts of the two-folding rollers, wherein the cutout part does not reach the nip between the central parts of the two-folding rollers when the sheets are folded, and a folding plate support member which is placed at a position facing the nip between the central parts of the two-folding rollers, and can slide in a direction of moving closer to or away from the nip, wherein the folding plate support member projects from the cutout part when the sheets are set, and does not reach the nip when the sheets are folded. | 2015-04-30 |
20150119224 | System For Producing Packaging Cushioning And Supply Structure Therefor - A supply structure for a supply of fan-folded sheet stock material, which is positionable relative to a cushion conversion machine to provide thereto the fan-folded sheet stock material for conversion thereof into packaging cushioning. The supply structure includes two or more supports, each of the supports including a base and a riser extending upwardly from the base. The base and the riser are structured and arranged to cooperatively accommodate a stack of the fan-folded sheet stock material. | 2015-04-30 |
20150119225 | CONICAL ROTOR DISCS FOR CENTRIFUGAL SEPARATOR AND ROTORS COMPRISING SUCH DISC ELEMENTS - Conical disc element ( | 2015-04-30 |
20150119226 | CENTRIFUGAL SEPARATOR - A centrifugal separator for cleaning crankcase gas, containing oil, from an internal combustion engine, includes a stationary casing defining a separation space and including a first end portion, an opposite second end portion and an inner wall surface facing the separation space. The separator also includes an inlet channel for the gas to be cleaned, a gas outlet channel for the cleaned gas and an oil outlet for the separated the oil. A centrifuge rotor is provided in the separation space and includes a spindle and a plurality of separation discs carried by the spindle. The centrifuge rotor is rotated to create a rotating gas volume. An oil supply device supplies such a quantity of oil to the separation space that a flowing oil film is created on the inner wall surface during operation of the centrifugal separator. | 2015-04-30 |
20150119227 | CRYSTALLIZED GLASS - To provide a crystallized glass capable of attaining the same clarification effect as in the composition containing an arsenic component and an antimony component even in the case of having the composition containing no arsenic component, while maintaining various physical properties peculiar to a Li | 2015-04-30 |
20150119228 | OPTICAL GLASS, PRECISION PRESS MOLDING PREFORM, AND OPTICAL ELEMENT AND METHOD OF MANUFACTURING THE SAME - The optical glass is described that may be an oxide glass including, denoted as cation %, a total of 5 to 60% of B | 2015-04-30 |
20150119229 | METHOD FOR PRODUCING ALUMINUM COMPOSITE MATERIAL - Provided is a method of producing an aluminum composite material, the method including: a decalcification treatment step of eluting a calcium oxide component from cement to form decalcified cement having a reduced content of the calcium oxide component; and an aluminum oxide formation step of bringing molten aluminum into contact with the decalcified cement to replace, among metal oxide components contained in the decalcified cement, metal oxide components other than the calcium oxide component, in particular, a silicon dioxide component, with aluminum oxide. | 2015-04-30 |
20150119230 | CERAMIC COMPOSITIONS COMPRISING ALUMINA - A composition may be suitable for firing to obtain a ceramic material therefrom. A green body or ceramic material may be formed from the composition. Ballistic armour may be formed from the composition or may include the ceramic material. | 2015-04-30 |
20150119231 | Synthesis of Polymeric Ionic Liquids Using a Photochemical Polymerization Process - Photo-initiated polymeric ionic liquids, methods of making and methods of using the same are disclosed. A preferred embodiment for making a photo-initiated polymeric ionic liquid (P-PIL) coated support, comprises: mixing at least one ionic liquid (IL) monomer with at least one photo-initiator; at least partially coating a support with the mixture; and exposing the coated support to UV light to form a photo-initiated polymeric ionic liquid (P-PIL) coated support. | 2015-04-30 |
20150119232 | SYSTEMS AND METHODS FOR SEPARATING CHLORINE-CONTAINING SPECIES FROM AQUEOUS SOLUTIONS OF CHLORINE-CONTAINING SPECIES - Disclosed is a method for separating a chlorine-containing species from an aqueous solution of the chlorine-containing species in a catalytic hydrocarbon conversion process that includes the step of oxidizing a spent chloride-containing hydrocarbon conversion catalyst, the spent hydrocarbon conversion catalyst including a hydrocarbon residue formed thereon. The oxidizing forms a flue gas including chlorine-containing species, water, and oxides of carbon. The method further includes contacting the flue gas with a water scrubbing stream to dissolve at least a portion of the chlorine-containing species in the water scrubbing stream to form an aqueous acid solution and contacting the aqueous acid solution with a hygroscopic liquid to generate dehydrated hydrogen chloride gas. Still further, the method includes contacting the dehydrated hydrogen chloride gas with additional spent chloride-containing hydrocarbon conversion catalyst to sorb chlorine onto the additional spent chloride-containing hydrocarbon conversion catalyst. | 2015-04-30 |
20150119233 | HIGHLY DISPERSED METAL OXIDE CATALYST COATINGS - Disclosed in certain implementations is a catalysis composition that includes a metal catalyst and a support material impregnated with the metal catalyst. | 2015-04-30 |
20150119234 | CATALYST COATINGS HAVING METAL OXIDE CRYSTALLITES - Disclosed in certain implementations is a catalysis composition that includes a metal catalyst and a support material impregnated with the metal catalyst. | 2015-04-30 |
20150119235 | CATALYST COATINGS INCORPORATING BINDER COMPOSITIONS - Disclosed in certain implementations is a catalysis composition that includes a metal catalyst and a support material impregnated with the metal catalyst. | 2015-04-30 |
20150119236 | OXIDATION CATALYST PREPARATION - A method for producing a catalyst by contacting a starting mixed metal oxide catalyst with an aqueous solution comprising oxalic acid and a metal oxide precursor to form a post-treated mixed metal oxide catalyst. | 2015-04-30 |
20150119237 | THERMAL IMAGING MEMBERS AND METHODS - There are described thermal imaging members and thermal imaging methods utilizing unsymmetrical rhodamine compounds. The rhodamine color-forming compounds exhibit a first color when in a crystalline form and a second color, different from the first color, when in an amorphous form. | 2015-04-30 |
20150119238 | METHOD AND DYE MIXTURES FOR MARKING SHAPE MEMORY POLYMERS, AND SHAPE MEMORY POLYMER ARTICLES WITH SWITCHABLE READABILITY - A method for marking an item including a shape memory polymer (SMP) having a visual readable and/or machine readable graphic element on the surface of the item. The method includes pretreating the surface of the item; colouring the surface of the item with a dye solution containing an organic dye and an organic solvent; cleaning and drying the surface of the item; and engraving by at least partially ablating the surface of the item. The dyeing process is suitable for colouring the surface of a shape memory polymer (SMP), wherein the information is engraved in a form of a code or other label on the coloured surface. The colouring causes an increased contrast and thus facilitates machine readability of marking and coding without affecting the other properties of the SMP. | 2015-04-30 |
20150119239 | AGROCHEMICAL COMPOSITIONS - The present invention related to an agrochemical composition comprising at least one protoporphyrinogen-IX oxidase inhibitor as defined in the claims and description and at least one inhibitor of complex II of the respiratory chain as defined in the claims and description. The invention further relates to the use of this composition for controlling undesired vegetation, for the desiccation and/or defoliation of plants, for controlling phytopathogenic fungi and for increasing the health of plants. The invention further relates to a method for controlling undesired vegetation, to a method for the desiccation and/or defoliation of plants, to a method for controlling phytopathogenic fungi and to a method for increasing the health of plants by using said composition. | 2015-04-30 |
20150119240 | ACTIVE COMPOUNDS COMBINATIONS COMPRISING A LIPO-CHITOOLIGOSACCHARIDE DERIVATIVE AND A NEMATICIDE, INSECTICIDAL OR FUNGICIDAL COMPOUND - The present invention relates to active compounds combinations which comprises (A) a lipo-chitooligosaccharide derivative and a further nematicide, insecticidal, acaricide or fungicidal compound (B). The present invention also relates to active compounds combinations which comprises further an additional nematicide, insecticidal, acaricide or fungicidal compound (C). Moreover, the invention relates to a method for curatively or preventively or eradicatively controlling harmful organisms, to a method for increasing yield or stimulating plant growth, to the use of a combination according to the invention for the treatment of seed or plant, to a method for protecting a seed and not at least to the treated seed. | 2015-04-30 |
20150119241 | 5-HALOGENOPYRAZOLE INDANYL CARBOXAMIDES - The present invention relates to novel 1-methyl-3-dihalogenomethyl-5-halogenopyrazole(thio)indanyl carbox-amides, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms in crop protection and in the protection of materials. | 2015-04-30 |
20150119242 | PYRAZOLE TETRAHYDRONAPHTHYL CARBOXAMIDES - The present invention relates to novel pyrazole(thio)tetrahydronaphthyl carboxamides, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms in crop protection and in the protection of materials. | 2015-04-30 |
20150119243 | PYRAZOLE INDANYL CARBOXAMIDES - The present invention relates to novel 1-methyl-pyrazole(thio)indanyl carboxamides, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms in crop protection and in the protection of materials. | 2015-04-30 |
20150119244 | AGRICULTURAL USES OF HYTd - Disclosed are compositions comprising chitosan, glucosamine and amino acids, where the concentration of chitosan is greater than 1.5 wt % and glucosamine is greater than 1.5 wt %. In preferred embodiments the concentration of chitosan is from 2 to 2.5 wt % and glucosamine is 2 to 6 wt %. The composition can also include solid chitin. The composition can also include trace elements, protein and other polysaccharides. The composition is generally a liquid but may be a solid. In most embodiments, the solid can be reconstituted with water prior to use. In preferred embodiments, the composition comprises HYTd and at least one of, HYTa, HYTb and HYTc. In other embodiments the composition comprises HYTd and two or more of, HYTa, HYTb and HYTc. The composition can also comprise HYTd, HYTa, HYTb and HYTc. In the disclosed processes soil, seed, seedling or plant foliage are contacted with HYTd or any of the above compositions. | 2015-04-30 |
20150119245 | Method for Producing Shelf Stable Hypochlorous Acid Solutions - A method for production and storage of hypochlorous acid is disclosed. The method comprises using high purity water achieved by a combination of softening and reverse osmosis steps. The shelf life is further improved by storing the hypochlorous acid in opaque PET bottles or Nylon/PE bags or nylon bags in a box. Solutions stored in opaque PET bottles exhibit the best stability. Anticipated uses of the extended life hypochlorous acid solution include sanitizer for food contact and non-food contact surfaces, a streak-free cleaner for smooth surfaces and a cut flower life extender. Other biocide uses include water treatment in oil and gas production, cooling tower, lazy river and swimming pools, process water distribution systems, drinking water, portable humidifier, fish tanks and treatment of metalworking fluids and lubricants. | 2015-04-30 |
20150119246 | COMPOSITIONS AND METHODS COMPRISING COLLETOTRICHUM FOR CONTROLLING PLANT SPECIES - Provided are methods and compositions for controlling at least one plant. Methods and compositions can comprise at least one strain of | 2015-04-30 |
20150119247 | Composition and Method for Stress Mitigation in Plants - A composition and method to mitigate plant autophagy and/or apoptosis of newly developing cells in plants grown under environmentally stressful growing conditions, such as high temperature. Exogenous application of a cytokinin, preferably kinetin, to either the roots or the foliage (i.e., flowers and leaves) of plants has been discovered to overcome, or at least substantially mitigate, autophagy when applied during or just prior to flowering. Experimental results indicate that high temperature-induced autophagy, and subsequent new cell apoptosis, is the result of a deficiency of cytokinin in the plant tissues. The application of low concentrations of potassium together with the cytokinin appears to provide a synergistic effect by amplifying the effect of the cytokinin to lessen autophagy and increase crop productivity. | 2015-04-30 |
20150119248 | TRANSGENIC BRASSICA EVENT MON 88302 AND METHODS OF USE THEREOF - The invention provides plants comprising transgenic event MON 88302 that exhibit tolerance to glyphosate herbicide. The invention also provides seeds, plant parts, cells, commodity products, and methods related to the event. The invention also provides DNA molecules that are unique to the event and were created by the insertion of transgenic DNA into the genome of a | 2015-04-30 |
20150119249 | Substituted N-(tetrazol-5-yl)- and N-(triazol-5-yl)pyridin-3-yl-carboxamide compounds and their use as herbicides - N-(tetrazol-5-yl)- and N-(triazol-5-yl)pyridin-3-yl-carboxamides of formula I and their use as herbicides, formula I. The invention relates to N-(tetrazol-5-yl)- and N-(triazol-5-yl)pyridin-3-yl-carboxamides of formula I and their use as herbicides. In said formula I, B represents N or CH, whereas R, R | 2015-04-30 |
20150119250 | METHODS FOR MODULATING PLANT RESPONSE TO ENVIRONMENTALLY-INDUCED STRESS - Compounds and methods are described herein that are effective to modulate plant response (e.g., plant susceptibility) to environmentally-induced stress. The compounds and methods described herein advantageously may be used to modulate environmental stress resistance in a wide variety of plants. Environmental stresses include, for example, high light intensity (UV exposure), temperature (e.g., high heat), high soil salinity, and low soil moisture (e.g., drought). As used herein, environmental stresses include any conditions that result in increased generation of reactive oxygen species (ROS) and accumulation of ROS in the plant cells. The compounds described herein that are effective to modulate resistance to the stress prevent, directly or indirectly, or increase phosphorylation of Tyr | 2015-04-30 |
20150119251 | AGRICULTURAL PLANT-PROTECTING AGENTS CONTAINING DIPEPTIDE DERIVATIVE AS ACTIVE INGREDIENT - Provided is an agricultural plant-protecting agent including a dipeptide derivative or an agro-pharmaceutically acceptable salt thereof as an active ingredient, which has a plant disease-preventing effect, a plant growth-promoting effect, and a plant immunity-activating effect. | 2015-04-30 |
20150119252 | SYSTEMS AND METHODS FOR FABRICATION OF SUPERCONDUCTING INTEGRATED CIRCUITS - Various techniques and apparatus permit fabrication of superconductive circuits. A niobium/aluminum oxide/niobium trilayer may be formed and individual Josephson Junctions (JJs) formed. A protective cap may protect a JJ during fabrication. A hybrid dielectric may be formed. A superconductive integrated circuit may be formed using a subtractive patterning and/or additive patterning. A superconducting metal layer may be deposited by electroplating and/or polished by chemical-mechanical planarization. The thickness of an inner layer dielectric may be controlled by a deposition process. A substrate may include a base of silicon and top layer including aluminum oxide. Depositing of superconducting metal layer may be stopped or paused to allow cooling before completion. Multiple layers may be aligned by patterning an alignment marker in a superconducting metal layer. | 2015-04-30 |
20150119253 | METHOD FOR INCREASING THE INTEGRATION LEVEL OF SUPERCONDUCTING ELECTRONICS CIRCUITS, AND A RESULTING CIRCUIT - A method for increasing the integration level of superconducting electronic circuits, comprising fabricating a series of planarized electrically conductive layers patterned into wiring, separated by planarized insulating layers, with vias communicating between the conductive layers. Contrary to the standard sequence of patterning from the bottom up, the pattern of vias in at least one insulating layer is formed prior to the pattern of wiring in the underlying conductive layer. This enables a reduction in the number of planarization steps, leading to a fabrication process which is faster and more reliable. In a preferred embodiment, the superconductor is niobium and the insulator is silicon dioxide. This method can provide 10 or more wiring layers in a complex integrated circuit, and is compatible with non-planarized circuits placed above the planarized wiring layers. | 2015-04-30 |
20150119254 | NUCLEIC ACID FRAGMENT BINDING TO TARGET PROTEIN - An object of the present invention is to develop and provide a method for efficiently producing a nucleic acid aptamer, particularly, a DNA aptamer, having higher specificity and binding activity against a target substance than those of nucleic acid aptamers obtained by conventional methods. The present invention provides a transcribable or replicable nucleic acid aptamer comprising a natural nucleotide and a non-natural nucleotide having an artificial base-pairable artificial base. The present invention also provides a method for sequencing a non-natural nucleotide-containing single-stranded nucleic acid molecule selected from a single-stranded nucleic acid library. | 2015-04-30 |
20150119255 | Digital Counting of Individual Molecules by Stochastic Attachment of Diverse Labels - Compositions, methods and kits are disclosed for high-sensitivity single molecule digital counting by the stochastic labeling of a collection of identical molecules by attachment of a diverse set of labels. Each copy of a molecule randomly chooses from a non-depleting reservoir of diverse labels. Detection may be by a variety of methods including hybridization based or sequencing. Molecules that would otherwise be identical in information content can be labeled to create a separately detectable product that is unique or approximately unique in a collection. This stochastic transformation relaxes the problem of counting molecules from one of locating and identifying identical molecules to a series of binary digital questions detecting whether preprogrammed labels are present. The methods may be used, for example, to estimate the number of separate molecules of a given type or types within a sample. | 2015-04-30 |
20150119256 | Digital Counting of Individual Molecules by Stochastic Attachment of Diverse Labels - Compositions, methods and kits are disclosed for high-sensitivity single molecule digital counting by the stochastic labeling of a collection of identical molecules by attachment of a diverse set of labels. Each copy of a molecule randomly chooses from a non-depleting reservoir of diverse labels. Detection may be by a variety of methods including hybridization based or sequencing. Molecules that would otherwise be identical in information content can be labeled to create a separately detectable product that is unique or approximately unique in a collection. This stochastic transformation relaxes the problem of counting molecules from one of locating and identifying identical molecules to a series of binary digital questions detecting whether preprogrammed labels are present. The methods may be used, for example, to estimate the number of separate molecules of a given type or types within a sample. | 2015-04-30 |
20150119257 | Digital Counting of Individual Molecules by Stochastic Attachment of Diverse Labels - Compositions, methods and kits are disclosed for high-sensitivity single molecule digital counting by the stochastic labeling of a collection of identical molecules by attachment of a diverse set of labels. Each copy of a molecule randomly chooses from a non-depleting reservoir of diverse labels. Detection may be by a variety of methods including hybridization based or sequencing. Molecules that would otherwise be identical in information content can be labeled to create a separately detectable product that is unique or approximately unique in a collection. This stochastic transformation relaxes the problem of counting molecules from one of locating and identifying identical molecules to a series of binary digital questions detecting whether preprogrammed labels are present. The methods may be used, for example, to estimate the number of separate molecules of a given type or types within a sample. | 2015-04-30 |
20150119258 | Digital Counting of Individual Molecules by Stochastic Attachment of Diverse Labels - Compositions, methods and kits are disclosed for high-sensitivity single molecule digital counting by the stochastic labeling of a collection of identical molecules by attachment of a diverse set of labels. Each copy of a molecule randomly chooses from a non-depleting reservoir of diverse labels. Detection may be by a variety of methods including hybridization based or sequencing. Molecules that would otherwise be identical in information content can be labeled to create a separately detectable product that is unique or approximately unique in a collection. This stochastic transformation relaxes the problem of counting molecules from one of locating and identifying identical molecules to a series of binary digital questions detecting whether preprogrammed labels are present. The methods may be used, for example, to estimate the number of separate molecules of a given type or types within a sample. | 2015-04-30 |
20150119259 | NUCLEIC ACID SEQUENCING BY NANOPORE DETECTION OF TAG MOLECULES - This disclosure provides systems and methods for sequencing nucleic acids using nucleotide analogues and translocation of tags from incorporated nucleotide analogues through a nanopore. In aspects, this disclosure is related to composition, method, and system for sequencing a nucleic acid using tag molecules and detection of translocation through a nanopore of tags released from incorporation of the molecule. | 2015-04-30 |
20150119260 | CIRCULATING CANCER BIOMARKER AND ITS USE - The present invention provides a chimera nucleic acid obtained from circulatory system for monitoring tumor status. The nucleic acid comprises partial sequence derived from host genome and partial sequence derived from non-host genome. The partial sequence derived from host genome and the partial sequence derived from non-host genome form a chimera junction. The chimera junction is obtained from cell-free nucleic acids and is indicative of disease status. | 2015-04-30 |
20150119261 | Enrichment of Target Sequences - Methods and compositions are provided for enriching for target sequences from a population of nucleic acids, that includes: combining in solution, a population of nucleic acids and a target isolation probe wherein the target isolation probe comprises an affinity binding domain; permitting a single stranded region of the target isolation probe to hybridize to all or a portion of a target sequence in the population of nucleic acids; selectively immobilizing the hybridized nucleic acids from the population containing the target sequences by associating the target isolation probe with a capture domain and removing unbound material; removing non-target sequences from the 3′ end of the target sequence by means of one or more 3′ exonucleases thereby generating a blunt ended duplex or a staggered end at the 3′ end of the target sequence; optionally ligating a 3′ duplex adaptor or a duplex end of a hairpin adaptor to the 3′ end of the target sequence and the 5′ end of the target isolation probe; extending the 3′ end of the target isolation probe to form a blunt end or a staggered end at the 5′ end of the target sequence suitable for ligating and ligating an adapter to the 5′ end of the target sequence and the 3′ extended end of the target isolation probe. | 2015-04-30 |
20150119262 | PREDICTION OF GENE TARGETS OF ENHANCERS - This disclosure relates generally to the prediction of a gene target of an enhancer based on genomic proximity and a comparison to a set of known enhancer-gene pairs. A gene can be selected a gene from a given cell type. A domain can be established bi-directionally around the gene, and enhancers located within the domain can be identified. The enhancers located within the domain can be considered to be in close genomic proximity to the gene. For each enhancer, a test pair of the enhancer and the gene can be established and compared to a set of known enhancer-gene pairs. The prediction can be established based on the comparison and the genomic proximity. | 2015-04-30 |
20150119263 | CARBON NANOTUBE BIOSENSORS AND RELATED METHODS - Disclosed are devices that comprise a protein, such as an antibody, placed into electronic communication with a semiconductor material, such as a carbon nanotube. The devices are useful in assessing the presence or concentration of analytes contacted to the devices, including the presence of markers for prostate cancer and Lyme disease. | 2015-04-30 |
20150119264 | DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE - The invention relates to novel variants that associate with Alzheimer's disease AD and their use in kits as a means for diagnosing AD; and also their use in nucleic acid molecules or cells/cell lines for identifying novel therapeutic, label of identification means. | 2015-04-30 |
20150119265 | METHOD FOR THE DIAGNOSIS OR PROGNOSIS, IN VITRO, OF LUNG CANCER - The subject matter of the present invention is a method for the diagnosis or prognosis, in vitro, of lung cancer, which includes a step of detecting at least one expression product of at least one HERV nucleic acid sequence, a method for use of said nucleic acid sequences, which have been isolated, as a molecular marker or molecular markers, and a kit including at least one binding partner specific for at least one of the expression products of the HERV nucleic acid sequences. | 2015-04-30 |
20150119266 | ANTIBODY ARRAY USED FOR THE ANALYSIS OF THE THREE-DIMENSIONAL STRUCTURE OF PROTEIN THERAPEUTICS AND ITS PRODUCTION - This invention relates to an antibody array for the analysis of the three-dimensional structure of a protein. It includes the development and production of the antibody array and methods of using the array to analyze the three-dimensional structure of a protein as well as to compare the three-dimensional structure of two proteins, for example, a therapeutic protein and a biosimilar, to determine if the two proteins are similar. | 2015-04-30 |
20150119267 | INHIBITION OF COLONY STIMULATING FACTOR-1 RECEPTOR SIGNALING FOR THE TREATMENT OF BRAIN CANCER - The present invention provides a method of screening brain tumor patients for treatment with inhibitor of CSF-1R, based on differential gene expression including adrenomeduUin (ADM), arginase 1 (ARG1), clotting factor F13A1, mannose receptor C type 1 (MRC1/CD206), and protease inhibitor SERPINB2 after treatment with the inhibitor. Based on the same differential gene expression profile, the present invention also provides a method of screening a compound to treat brain cancer. | 2015-04-30 |
20150119268 | APPARATUS WITH HETEROGENEOUS PROCESSING MODULES - A biological sample processing apparatus having an enclosure. A plurality of sample processing modules are held by the enclosure. Each sample processing module is configured to hold a removable sample cartridge and to only perform sample processing on a sample within the corresponding removable sample cartridge. Each sample processing module is configured to perform at least one of a plurality of testing processes on the sample within the removable sample cartridge. At least one module in the apparatus is configured to perform nucleic acid amplification and detection. | 2015-04-30 |
20150119269 | METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF STROKE OR OTHER CEREBRAL INJURY - The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in stroke patients and in patients at risk for stroke. In particular, the invention relates to using assays that detect one or more biomarkers as diagnostic and prognostic biomarker assays in such patients. | 2015-04-30 |
20150119270 | METHODS FOR DETECTING ALLOSTERIC MODULATORS OF PROTEIN - The present invention discloses, inter alia, methods for labeling a target protein with an SHG-active probe for detection by second harmonic or sum-frequency generation in order to identify agents which bind to an allosteric site on the target protein thereby altering its structural conformation | 2015-04-30 |
20150119271 | BIOMARKERS FOR THE DIAGNOSIS, PROGNOSIS, ASSESSMENT AND THERAPY STRATIFICATION OF SYNCOPE - The present invention relates to a method for the diagnosis and/or prognosis and/or assessment and/or therapy stratification of syncope in a patient the method comprising: determining the level of at least one biomarker selected from the group consisting of proET-1, pro ADM, proANP, proBNP, proAVP and PCT or a fragment of at least 12 amino acids thereof, in a sample of a bodily fluid of said patient, correlating said level of at least one biomarker or fragments thereof with the diagnosis and/or prognosis and/or assessment and/or therapy stratification of syncope. | 2015-04-30 |
20150119272 | DOSE-RESPONSE MEDICAL OUTCOME MODEL PREDICTOR SYSTEM AND METHOD - The invention provides a computer-implemented method and system for predicting quantitatively whether an adjuvant or neoadjuvant chemotherapeutic treatment will be or is being successful in treating an individual suffering from cancer. | 2015-04-30 |
20150119273 | Chronic Traumatic Encephalopathy in Blast-Exposed Individuals - The invention is based on the surprising discovery that as few as one episode of blast exposure increases the risk of CTE. Blast exposure is associated with chronic traumatic encephalopathy, impaired neuronal function, and persistent cognitive deficits in blast-exposed military veterans and experimental animals. Early diagnosis and assessment of risk permits physicians to prescribe treatment to reduce or slow progression of impairment before the onset of overt symptoms that become apparent decades after an initial insult or trauma to brain tissue. The invention provides methods and compositions for diagnosis and prognosis of individuals at risk of long term complications related to blast injury or concussive injury. | 2015-04-30 |
20150119274 | Microplates with Enhanced Immobilisation Capabilities Controlled by Magnetic Field - The present invention describes microplates with arrays of wells containing magnetic inserts in the form of disks, cylinders or otherwise shaped materials with apertures in the centre for optical interrogation of the contacting solution. These inserts are capable of capturing ferro- and paramagnetic nano- and microparticles. The subject microplates find use in a variety of applications, including clinical and environmental assays, high throughput screening for genomics, proteomics and pharmaceutical applications, point-of-care in vitro diagnostics, molecular genetic analysis and nucleic acid diagnostics, cell separations, and bioresearch generally and high-throughput screening of materials for separation and catalysis. | 2015-04-30 |
20150119275 | Methods for Diagnosing, Staging, Predicting Risk for Developing and Identifying Treatment Responders for Rheumatoid Arthritis - Disclosed are methods for diagnosing, staging, and predicting risk for developing rheumatoid arthritis and other inflammatory diseases, and methods for identifying treatment responders and non-responders. | 2015-04-30 |
20150119276 | IMMUNOREACTIVE EHRLICHIA P120/P140 EPITOPES AND USES THEREOF - Provided herein are immunoreactive peptides which can selectively bind | 2015-04-30 |
20150119277 | CANDIDA TROPICALIS OLIGONUCLEOTIDES, DETECTION METHOD, AND KIT THEREOF - The invention discloses an in vitro method for the identification of | 2015-04-30 |
20150119278 | BIOMARKERS AND DIAGNOSTIC METHODS FOR ALZHEIMER'S DISEASE AND OTHER NEURODEGENERATIVE DISORDERS - The present invention relates to biomarkers and diagnostic and prognostic methods for Alzheimer's disease and other neurodegenerative disorders. The invention also provides compositions for detecting the biomarker as well as compositions and methods useful for treating Alzheimer's disease and other neurodegenerative disorders. | 2015-04-30 |
20150119279 | SALIVARY BIOMARKERS FOR PREDIABETES AND TYPE 2 DIABETES - The present invention provides for the first time the identification of salivary protein and RNA factors that can be used in the detection of diabetes. The present invention therefore provides methods of diagnosing and providing a prognosis for diabetes, by examining relevant proteins and RNA in a patient's saliva. | 2015-04-30 |
20150119280 | Hydrogel Microstructures with Immiscible Fluid Isolation for Small Reaction Volumes - Techniques for hydrogel microstructures with oil isolation for small reaction volumes include providing a hydrogel microstructure that has a plurality of pores and a hydrogel frame surrounding the pores. The microstructure has a volume in a range from about 1 picoliter to about 10,000 picoliters and is configured to repel an immiscible fluid. Each pore of the plurality of pores has a pore size configured to pass the target molecule in a first solution. The microstructure is contacted with the first solution, and with a second solution that includes a reactant molecule that reacts with the target molecule to produce an observable product molecule. The microstructure is encompassed with the immiscible fluid for an extended observation duration from about 1 to about 10,000 seconds, wherein the immiscible fluid does not pass into the pores but traps the product in the microstructure. The observable product molecule is measured at some time during the observation duration. | 2015-04-30 |
20150119281 | PHOSPHINE DERIVATIVES OF FLUORESCENT COMPOUNDS - A phosphine derivative of DyLight dyes modified with ethylene glycol or (poly)ethylene glycol groups. In one embodiment, the compounds are useful in chemoselective ligation reactions. | 2015-04-30 |
20150119282 | MARKERS FOR THE DETECTION OF HUMAN EMBRYO DEVELOPMENTAL QUALITY - Markers are provided for genetic and epigenetic diagnosis of embryos to determine those of which are more likely to be chromosomally normal and advance in development. | 2015-04-30 |
20150119283 | METHOD AND SYSTEM FOR THE ANALYSIS OF HIGH DENSITY CELLS SAMPLES - Methods for forming cell arrays of multiple cell samples arranged substantially in a monolayer on a single substrate particularly suited for diagnostic analysis are disclosed. The cell arrays are formed with a high-speed dispensing apparatus capable of dispensing small volumes in precise, complex patterns. Also disclosed are substrates upon which cell arrays may be formed, and methods for conducting diagnostic analyses on the formed cell arrays. | 2015-04-30 |
20150119284 | ENCODED MICROCAPSULES AND MICROARRAY FABRICATED THEREFROM - Disclosed is a microcapsule encoded depending on the kind of a target substance included therein. The encoded microcapsule has a hydrophilic liquid core including the target substance and a hydrophobic shell surrounding the liquid core. The encoded microcapsule includes graphical codes introduced on the surface of the shell. | 2015-04-30 |
20150119285 | MAGNETIC-ASSISTED RAPID APTAMER SELECTION METHOD FOR GENERATING HIGH AFFINITY DNA APTAMER - A magnetic-assisted rapid aptamer selection (MARAS) protocol for screening DNA aptamer is proposed. The MARAS protocol is able to efficiently generate aptamers with high affinity and specificity. A rotating magnetic field or alternating magnetic field was used in combination with target-bound magnetic micro-particles or nanoparticles to select DNA aptamers having desirable affinity and specificity to the target. | 2015-04-30 |
20150119286 | HIGH-THROUGHPUT CORROSION TESTING PLATFORM - A high-throughput corrosion testing mechanism was developed for metals in a variety of environments in controlled, multiplexed microenvironments. Many parallel experiments can be conducted with microbial and environmental variables independently manipulated to identify the key determinants of corrosion progression. The synthetic assay design enables subsequent surface characterization of select samples within the array. In as little as one day, diverse corrosive environments can be compared quantitatively. | 2015-04-30 |
20150119287 | Single-Molecule PCR on Microparticles in Water-In-Oil Emulsions - Modulation of the viscosity of the oil phase of a microemulsion used for amplification of DNA on a bead increases the homogeneity of product beads and the amount of amplified DNA per bead. Moreover the number of separate microemulsion populations that can be formed in parallel is increased using multi-well plates and mixer mill disrupter machines designed to lyse biological samples. | 2015-04-30 |
20150119288 | KITS FOR MULTIPARAMETRIC PHOSPHO ANALYSIS - As disclosed herein, the present invention provides for kits and a composition for diagnosis, prognosis, drug discovery, drug development, and patient stratification. The kits can comprise a plurality of binding elements for cell surface markers, and a plurality of binding elements for state-specific intracellular markers. The kits can further comprise a plurality of modulators directed for the particular cell function or signaling pathways. The kits can further include fixatives, permeabilizing agent, buffers, containers, instructions, and software for data analysis/compilation. | 2015-04-30 |
20150119289 | METHODS TO DETERMINE CANDIDATE BIOMARKER PANELS FOR A PHENOTYPIC CONDITION OF INTEREST - A panel of lymphoma related biomarkers are provided. The panel allows the identification of a subject at risk for a lymphoma. Further provided are methods of optimizing therapeutic efficacy associated with treatment of a lymphoma related disorder. Methods of identifying biomarkers affiliated with a condition of interest are provided. | 2015-04-30 |
20150119290 | Digital Counting of Individual Molecules by Stochastic Attachment of Diverse Labels - Compositions, methods and kits are disclosed for high-sensitivity single molecule digital counting by the stochastic labeling of a collection of identical molecules by attachment of a diverse set of labels. Each copy of a molecule randomly chooses from a non-depleting reservoir of diverse labels. Detection may be by a variety of methods including hybridization based or sequencing. Molecules that would otherwise be identical in information content can be labeled to create a separately detectable product that is unique or approximately unique in a collection. This stochastic transformation relaxes the problem of counting molecules from one of locating and identifying identical molecules to a series of binary digital questions detecting whether preprogrammed labels are present. The methods may be used, for example, to estimate the number of separate molecules of a given type or types within a sample. | 2015-04-30 |
20150119291 | NUCLEIC ACID AMPLIFICATION - The present invention provides methods for the amplification of nucleic acid molecules. Methods for amplifying target polynucleotides, including mRNA, using oligonucleotides, DNA and RNA polymerases are provided. The invention further provides compositions and kits for practicing the methods, as well as methods which use the amplification products. | 2015-04-30 |
20150119292 | METHOD FOR RETAINING EVEN COVERAGE OF SHORT INSERT LIBRARIES - The invention relates to a method of preparing a library of template polynucleotides with uniform sequence representation and to use of a library of templates prepared using this method for solid-phase nucleic acid amplification. In particular, the invention relates to a method of preparing a library of template polynucleotides which have common sequences at their 5′ ends and at their 3′ ends, which contains even representation of all the fragments present in a starting sample of nucleic acid before fragmentation. The invention is especially applicable to the preparation of short insert libraries, where the sample fragments are less than 150 base pairs in length. | 2015-04-30 |
20150119293 | SYNTHETIC LIGATION REASSEMBLY IN DIRECTED EVOLUTION - A directed evolution process for rapid and facilitated production from a progenitor polynucleotide template, of a library of mutagenized progeny polynucleotides wherein each of the 20 naturally encoded amino acids is encoded at each original codon position. This method, termed site-saturation mutagenesis, or simply saturation mutagenesis, is preferably based on the use of the degenerate N,N,G/T sequence. Also, a method of non-stochastically producing a library of chimeric nucleic acid molecules having an overall assembly order that is chosen by design. Accordingly, a set of progenitor templates, such as genes (e.g. a family of esterase genes) or genes pathways (e.g. encoding antibiotics) can be shuffled to generate a sizable library of distinct progeny polynucleotide molecules (e.g. 10 | 2015-04-30 |
20150119294 | SYNTHETIC POLYPEPTIDE LIBRARIES AND METHODS FOR GENERATING NATURALLY DIVERSIFIED POLYPEPTIDE VARIANTS - The invention provides compositions and methods for generating libraries of DNA sequences encoding homologous polypeptides, and uses of the libraries to identify naturally diversified polypeptide variants. The invention also provides compositions and methods for generating collections of synthetic antibody fragments in which one or several complementary determining regions (CDR) are replaced by a collection of the corresponding CDR captured from a natural source. The invention further provides compositions and methods for diversifying a portion of a polypeptide by inserting a diversified sequence of synthetic or natural origin without the need for modification of the original polypeptide coding sequence. | 2015-04-30 |
20150119295 | METHODS OF LOCALIZING NUCLEIC ACIDS TO ARRAYS - Methods are disclosed relating to generating a silene-free slide comprising the steps of providing a plastic substrate; providing a solution of acrylamide comprising N-(5-bromoacetamidylpentyl) acrylamide (BRAPA); contacting the acrylamide/BRAPA solution with a polymerizing agent; contacting the acrylamide/BRAPA solution with an oxidizing agent; and contacting the acrylamide/BRAPA/polymerizing agent/oxidizing agent to the plastic substrate. | 2015-04-30 |