17th week of 2010 patent applcation highlights part 37 |
Patent application number | Title | Published |
20100104597 | N-linked glycosylation alteration in E0 and E2 glycoprotein of classical swine fever virus and novel classical swine fever virus vaccine - E2 is one of the three envelope glycoproteins of Classical Swine Fever Virus (CSFV). E2 is involved in several functions including virus attachment and entry to target cells, production of antibodies, induction of protective immune response in swine, and virulence. Seven putative glycosylation sites in E2 were modified by site directed mutagenesis of a CSFV Brescia infectious clone (BICv). A panel of virus mutants was obtained and used to investigate whether the removal of putative glycosylation sites in the E2 glycoprotein would affect viral virulence/pathogenesis in swine. We observed that rescue of viable virus was completely impaired by removal of all putative glycosylation sites in E2, but restored when mutation N185A reverted to wild-type asparagine produced viable virus that was attenuated in swine. Single mutations of each of the E2 glycosylation sites showed that amino acid N116 (N1v virus) was responsible for BICv attenuation. N1v efficiently protected swine from challenge with virulent BICv at 3 and 28 days post-infection suggesting that glycosylation of E2 could be modified for development of CSF live-attenuated vaccines. Additionally, a new developed virus, contained deletions of putative glycosylation sites N1 in E2 and N1 in E0 (6b), called N1E0/2v, induce a solid protection against the challenge at 3 and 28 days post-inoculation. | 2010-04-29 |
20100104598 | DEVELOPMENT OF DENGUE VIRUS VACCINE COMPONENTS - The invention is related to a dengue virus or chimeric dengue virus that contains a mutation in the 3′ untranslated region (3′-UTR) comprising a Δ30 mutation that removes the TL-2 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, and nucleotides additional to the Δ30 mutation deleted from the 3′-UTR that removes sequence in the 5′ direction as far as the 5′ boundary of the TL-3 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, or a replacement of the 3′-UTR of a dengue virus of a first serotype with the 3′-UTR of a dengue virus of a second serotype, optionally containing the Δ30 mutation and nucleotides additional to the Δ30 mutation deleted from the 3′-UTR; and immunogenic compositions, methods of inducing an immune response, and methods of producing a dengue virus or chimeric dengue virus. | 2010-04-29 |
20100104599 | Compositions and Methods For Enhancing Immune System of Felines - Compositions and methods useful to enhance the development of the immune system of a growing animal are disclosed. | 2010-04-29 |
20100104600 | Methods and Compositions for Increasing Tissue Tropism of Recombinant Adenoviral Vectors - Methods are provide to allow for the preparation of adenoviral vectors with altered tropism. Compositions comprising such vectors and methods of use thereof also are provided. | 2010-04-29 |
20100104601 | TREATMENT OF IMMUNE DISEASE BY MUCOSAL DELIVERY OF ANTIGENTS USING GENETICALLY MODIFIED LACTOBACILLUS - The present invention relates to the treatment of autoimmune and allergic diseases by mucosal delivery by micro-organism, in particular | 2010-04-29 |
20100104602 | Neurotoxin therapy for postprandial hyperglycemia - Botulinum toxin is increasingly being injected into visceral smooth muscle for a variety of indications. The present invention discloses intragastric administration of botulinum toxin to delay gastric emptying with the aim of inducing satiety and promoting weight-loss. The present invention also discloses the effects of intragastric administration of Botulinum toxin in reducing post-prandial hyperglycemia in patients suffering from Diabetes Mellitus. | 2010-04-29 |
20100104603 | USE OF STAPHYLOCOCCAL SUPERANTIGEN-LIKE PROTEIN 5 (SSL5) IN MEDICINE - The present invention relates to Staphylococcal superantigen-like protein 5 (SSL5) or homologues or derivatives thereof for use in medicine, in particular for use in the treatment of indications involving an excessive recruitment of leukocytes, such as stroke, perfusion/ischemia, transplant rejection, rheumatoid arthritis. The invention further relates to a pharmaceutical composition comprising SSL5 and a suitable excipient. The invention also provides the use of SSL5 for the preparation of a medicament for treatment of indications involving an excessive recruitment of leukocytes to a site of tissue damage, such as stroke, reperfusion/ischemic, transplant rejection and rheumatoid arthritis. | 2010-04-29 |
20100104604 | Compositions and Methods to Elicit Immune Responses Against Pathogenic Organisms Using Yeast Based Vaccines - Embodiments of the present invention illustrate methods of treating and preventing infection due to a pathogen such as a fungal pathogen. In particular, the present invention relates to compositions and methods for vaccinations against or treatment for a fungal organism in a non-immunocompromised or immunocompromised subject. | 2010-04-29 |
20100104605 | Method for preventing and treating influenza - The present invention provides a method for making pressure-induced ganoderma spores, for using the pressure-induced ganoderma spores to ameliorate and/or prevent influenza in a mammal; and to stimulating the host immune system in a mammal. The method for making the pressure-induced ganoderma spores includes (1) soaking ganoderma spores in a solution; (2) drying the soaked ganoderma spores using a freeze-drying or a vacuum-drying method; (3) breaking the sporoderms of the dried ganoderma spores with enzyme or a mechanical method; (4) pressurizing and depressurizing the sporoderm-broken ganoderma spores to obtain the pressure-induced sporoderm-broken ganoderma spores. The methods for ameliorating and/or preventing influenza, and for stimulating the host immune system include orally administering a composition comprising the pressure-induced ganoderma spores to a mammal susceptible to or suffering from influenza. The present invention also provides the pressure-induced ganoderma spores. | 2010-04-29 |
20100104606 | ALLERGEN FRAGMENTS - The present invention relates to a peptide derived from the ragweed pollen allergen Amb a (1) and comprising (6 to 50) amino acid residues and pharmaceutical preparations comprising said peptide and uses thereof. | 2010-04-29 |
20100104607 | ANTI-BACTERIAL PEPTIDES AND METHODS OF TREATING DISEASES USING SAME - Isolated peptides comprising no more than ten amino acids and having anti-bacterial properties are disclosed. In one embodiment the peptides have a consensus amino acid sequence X | 2010-04-29 |
20100104608 | REACTIVE SURGICAL IMPLANT - Biocompatible implants include a polymer substrate and a reactive component selectively applied to the substrate. The reactive component in combination with the substrate creates crosslinked regions on a surface of the substrate. The crosslinked regions may provide a visual aid and/or stiffening element to the implant. | 2010-04-29 |
20100104609 | HAIR COSMETIC COMPOSITION - A leave-on type hair cosmetic composition having the following two layers A and B:
| 2010-04-29 |
20100104610 | Color cosmetics comprising a random terpolymer - Topically applicable, water-resistant cosmetic or dermatological compositions well suited for the cosmetic color compositions for human skin and/or hair comprising at least one
| 2010-04-29 |
20100104611 | ANTIPERSPIRANT COMPOSITIONS - Anhydrous antiperspirant compositions comprising particulate antiperspirant active; capsules comprising a shear-sensitive shell which encapsulates perfume; and a carrier for the particulate antiperspirant active and capsules; wherein the capsules have a shell of cross-linked gelatin coacervate having a thickness of from 0.25 to 9 μm and providing from 10 to 40% by weight of the capsules, a volume average particle diameter of from 25 to 70 μm, a ratio of shell thickness to the average particle diameter in the range of from 1:5 to 1:120, and a Hysitron hardness in the range of from 1.5 MPa to 50 MPa. | 2010-04-29 |
20100104612 | ANTIPERSPIRANT COMPOSITIONS - Fragrance leaches rapidly from capsules having shells made from cross linked gelatin into volatile silicone oils. Unfortunately such oils are much favoured for anhydrous antiperspirant compositions. The rate and extent of leaching can be ameliorated greatly or nearly halted by employing as carrier oil, an ester oil or an ether oil, even in the presence of a significant fraction of volatile silicone oil. Consequently, the capability of antiperspirant compositions to generate detectable fragrance over an extended period after application to the skin is improved by employing ester or ether oil as all or part of the carrier liquid in which the antiperspirant is suspended. | 2010-04-29 |
20100104613 | ANTIPERSPIRANT OR DEODORANT COMPOSITIONS - It is desirable for antiperspirant or deodorant roll-on compositions to be able to deliver fragrance over an extended period of time after application, but previously contemplated encapsulates were based on starch or similar water-soluble or dispersible shell materials, rendering them ineffective in aqueous emulsions. | 2010-04-29 |
20100104614 | PROVIDONE COMPOSITIONS FOR WOUND HEALING - Described here are wound dressings and kits. The wound dressings include povidone compositions that may be directly applied to wound surfaces or provided on substrates to form a composite material. The povidone compositions contain a povidone polymer, where the povidone polymer itself is capable of healing wounds. The povidone compositions may be in particulate form. In other instances, the povidone compositions are formulated as gels, ointments, pastes, films, or other topically applied compositions. Methods for applying the povidone compositions to treat wounds are also described. | 2010-04-29 |
20100104615 | ABSORBENT ARTICLE COMPRISING LACTIC ACID PRODUCING BACTERIA - The present invention relates to absorbent articles comprising at least a liquid acquisition layer and an underlying liquid storage layer, said absorbent article comprising lactic acid producing bacteria. The lactic acid producing bacteria are dispersed in a hydrophobic carrier and the article further comprises at least one super-absorbent polymer. At least a part of the total amount of super-absorbent polymer and at least a part of the total amount of the bacteria are present in the liquid storage layer. | 2010-04-29 |
20100104616 | PROCESS - A process for making parasite repellent absorbent material, including:
| 2010-04-29 |
20100104617 | GRAFT PROSTHESIS, MATERIALS AND METHODS - A graft prostheses ( | 2010-04-29 |
20100104618 | POLYMER-BASED SURGICALLY IMPLANTABLE HALOPERIDOL DELIVERY SYSTEMS AND METHODS FOR THEIR PRODUCTION AND USE - Surgically implantable drug delivery systems for long-term delivery of haloperidol containing a biodegradable polymer and haloperidol fabricated into the surgically implantable drug delivery systems via solvent casting and compression molding are provided. Also provided are methods for producing the surgically implantable drug delivery systems and methods for using these systems in the treatment of psychotic disorders such as schizophrenia. | 2010-04-29 |
20100104619 | DELIVERY SYSTEM FOR A NON-STEROIDAL NON-IONIZED HYDROPHILIC DRUG - This invention relates to an extended release formulation comprising a solid non-steroidal non-ionized hydrophilic drug, having a molecular weight below 500 Dalton and having a solubility of at least 0.1 wt % in ethylene vinyl acetate copolymer having a vinyl acetate content of 28%, which formulation is a vaginal device having a skin and which device comprises an inner compartment made of a thermoplastic polymer, which polymer is containing the drug. The polymer is preferably made of ethylene-vinyl acetate copolymer. | 2010-04-29 |
20100104620 | OVER-COATED PRODUCT INCLUDING TABLETED CENTER AND MEDICAMENT - Methods and products for delivering a medicament or agent to an individual are provided as well as methods for producing the product. The product includes a coating having a medicament or agent. The medicament or agent is present within the coating that surrounds a tableted center. The tableted center is defined by compressible excipients. By chewing the product, the medicament or agent is released from the product within the buccal cavity. | 2010-04-29 |
20100104621 | TREATING ADHD AND OTHER DISEASES INVOLVING INFLAMMATION - The present disclosure relates to methods and drug delivery systems for treating diseases involving inflammation, including Attention Deficit Hyperactivity Disorder (ADHD) by administering a CNS stimulant to a patient in need thereof so as to maintain steady state serum drug levels that remain therapeutically effective for about 24 and ½ to about 25-27 hours or longer after administration to maintain a constant steady state between doses of medication. The method is employed to restore normal catecholamine levels throughout the day without over-stimulating or under-stimulating the patient. Additionally, the present method of treating inflamτnaτion3 including ADHD, provides, for example, dosing once a day or once a week. The present method also addresses other aspects of the disease, for example, defective P-5-P synthesis, ehminating interleukins and free radicals, and correction of Amino acids, the endocrine system and inflammation. The present systems and methods heal the brain, treat depression and ADHD, and may lower the amount of medication needed over time. | 2010-04-29 |
20100104622 | Ligand Targeted Nanocapsules for the delivery of RNAi and other Agents - A carrier system for the delivery of therapeutic and/or diagnostic agents is described. The carrier system is comprised of ligands and a biodegradable polycation for complexing polyanionic molecules such as RNAi, said polycation forming a coating on the outer surface of anionic or neutral liposomes. Also disclosed is a method for using the composition to deliver to target cells and enhance cell membrane penetration of therapeutic and/or diagnostic agents. | 2010-04-29 |
20100104623 | AGENT FOR ENHANCING THE RESISTANCE OF LIPOSOME AGAINST BIOLOGICAL COMPONENT, AND LIPOSOME MODIFIED WITH THE AGENT - It is intended to provide a positively charged liposome, particularly having a polyarginine peptide on a surface thereof, which is capable of increasing the resistance to a negatively charged biological component such as a protein in the blood and maintaining a high ability to deliver a substance even in the blood. An agent for enhancing the resistance of liposome against biological component comprising a peptide having at least one of the following characteristics (a) and (b) as an active ingredient:
| 2010-04-29 |
20100104624 | COMBINATION THERAPY USING PHOSPHODIESTERASE INHIBITORS - Described here are compositions and methods for treating side-effects of vasodilator therapy. The compositions may include both a vasodilator and a side-effect alleviating agent in a single dosage form. Alternatively, the vasodilator and side-effect alleviating agent may be formulated separately, each in its own dosage form. The compositions may be packaged as kits for use with various medical conditions. | 2010-04-29 |
20100104625 | BIODEGRADABLE COMPOSITIONS AND MATERIALS - The present invention provides compounds of Formula I, materials comprising one or more compounds of Formula I and one or more biologically active agents, pharmaceutical compositions comprising an inventive material and a pharmaceutically acceptable excipient, methods of making compounds of Formula I, methods of making inventive materials, and methods of using pharmaceutical compositions comprising an inventive material and a pharmaceutically acceptable excipient. | 2010-04-29 |
20100104626 | METHODS AND COMPOSITIONS FOR TREATING AND DIAGNOSING KIDNEY DISEASE - The invention relates to a method for diagnosing a kidney disease state. The method comprises the steps of administering to a patient a composition comprising a conjugate or complex of the general formula V-L-D where the group V comprises a vitamin receptor binding ligand that binds to kidney proximal tubule cells and the group D comprises a diagnostic marker, and diagnosing the kidney disease state. The invention also relates to a method for treating a kidney disease state. The method comprises the steps of administering to a patient suffering from the disease state an effective amount of a composition comprising a conjugate or complex of the general formula V-L-D where the group V comprises a vitamin receptor binding ligand that binds to kidney proximal tubule cells and the group D comprises an antigen, a cytotoxin, or a cell growth inhibitor, and eliminating the disease state. | 2010-04-29 |
20100104627 | STABLE AQUEOUS G-CSF FORMULATIONS - The invention relates to stable glutamate-buffered G-CSF formulations having a pH of from 3.5 to 4.8. The invention further concerns lyophilisates and powders obtainable from such formulations, and to pharmaceutical kits containing such lyophilisates and powders. | 2010-04-29 |
20100104628 | METHOD OF TREATING NEUROBLASTOMA - The present invention relates, in general, to neuroblastoma and, in particular, to a method of treating neuroblastoma tumors, including refractory neuroblastoma tumors. The invention also relates to compounds and compositions suitable for use in such a method. | 2010-04-29 |
20100104629 | CATIONIC LIPIDS AND USES THEREOF - Cationic lipids, cationic lipid based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed. | 2010-04-29 |
20100104630 | WATER SOLUBLE STATIN MICROSTRUCTURES AND METHOD OF PREPARATION - A method of preparing a water soluble microstructure includes the steps of providing a saturated solution of a payload with poor water solubility, providing a solution of helper molecules, and combining the saturated solution of the payload with the solution of helper molecules. The combined saturated solution of the payload with the solution of helper molecules is mixed with an aqueous solution to form a water soluble microstructure. The water soluble microstructure includes the helper molecules forming an outside portion of the microstructure, and the payload having poor water solubility contained within the outside portion and forming an inside portion of the microstructure. | 2010-04-29 |
20100104631 | METHOD OF TREATMENT FOR BLADDER DYSFUNCTION - Liposomes are used for intravesical drug delivery, especially delivery of botulinum toxin (BoNT) to help improve lower urinary tract symptoms by decreasing bladder irritation and frequency. The system uses a lower and safer dose of BoNT with lower risk of urinary retention. A simple instillation of liposome-BoNT as a liquid formulation into the bladder, in a typical volume of 30-60 ml, will achieve efficacy similar to that currently achieved with cystscopic needle injection of BoNT. The dose may be lower than that done by injection, thereby causing significantly less risk of urinary retention. Liposome-BoNT can protect the BoNT from bladder and urine breakdown. Liposome-BoNT instillation is more comfortable for the patients and allows many more doctors' offices to offer this form of treatment that would otherwise be restricted to doctors skilled and certified in cystoscopic BoNT injection. | 2010-04-29 |
20100104632 | Drug Having Regulatory Cell Ligand Contained in Liposome - A liposome containing a regulatory cell ligand such as α-galactosyl ceramide or β-galactosyl ceramide is employed as the active ingredient of a drug for preventing or treating immune diseases etc. | 2010-04-29 |
20100104633 | TOPICAL TERBINAFINE FORMULATIONS AND METHODS OF ADMINISTERING SAME FOR THE TREATMENT OF FUNGAL INFECTIONS - The present invention relates to topical antifungal formulations terbinafine or a pharmaceutically acceptable salt thereof, a lipid, and a surfactant, and uses thereof for the treatment of skin and nail fungal infections. | 2010-04-29 |
20100104634 | PHARMACEUTICAL COMPOSITIONS OF ENTACAPONE - The invention relates to pharmaceutical compositions comprising entacapone or pharmaceutically acceptable salts thereof. The invention also relates to processes for the preparation of such compositions. | 2010-04-29 |
20100104635 | PROCESS FOR PREPARING GRANULES OF HYDROPHILIC VITAMINS - The present invention relates to a process for preparing granules of a hydrophilic vitamin with polyvinylpyrrolidone as binder in a fluidized bed granulator, to the granules of a hydrophilic vitamin obtained by said process, to tablets made with said granules of a hydrophilic vitamin, to mixture of L-ascorbic acid for direct tabletting and tablets made with said mixtures. | 2010-04-29 |
20100104636 | Pharmaceutical Compound and Composition - A pharmaceutical composition comprising rosiglitazone or a pharmaceutically acceptable salt thereof wherein said rosiglitazone has a median particle size diameter of about 5 microns to about 20 microns. | 2010-04-29 |
20100104637 | TABLET FORMULATIONS CONTAINING 8-[-METHYL]-8-PHENYL-1,7-DIAZA-SPIRO[4.5]DECAN-2-ONE SALTS AND TABLETS MADE THEREFROM - Pharmaceutical formulations containing a salt of (5S,8S)-8-[{(1R)-1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2-one, represented by Formula I, which are suitable for forming into a tablet dosage form, as well as tablet dosage forms are disclosed. Disclosed also are methods of treatment utilizing such dosage forms. | 2010-04-29 |
20100104638 | EXTENDED RELEASE ORAL ACETAMINOPHEN/TRAMADOL DOSAGE FORM - An extended release oral administered dosage form of acetaminophen and tramadol. The dosage form includes a composition of acetaminophen together with a tramadol complex formed with an anionic polymer. The tramadol complex provides sustained release of tramadol for a synchronized (coordinated) release profile of acetaminophen and tramadol. | 2010-04-29 |
20100104639 | BUPROPION HYDROBROMIDE AND THERAPEUTIC APPLICATIONS - Bupropion hydrobromide formulations as well as their use for the treatment of conditions is described. | 2010-04-29 |
20100104640 | PHARMACEUTICAL COMPOSITIONS COMPRISING IRBESARTAN - The present invention relates to a pharmaceutical composition comprising irbesartan. | 2010-04-29 |
20100104641 | THERAPEUTIC COMPOSITION, AND USE OF A CELL-FREE SUBSTANCE - The invention relates to a therapeutic composition, a method for producing a therapeutic composition, and the use of a cell-free substance, especially a cell-free bone or cartilage matrix. The disclosed therapeutic composition comprises at least a cell-free substance obtained from stimulated stem cells and/or precursor cells. Immunogenic reactions during in vivo therapeutic use are prevented by the fact that the therapeutic composition is free from cells and contains no typically antigenic cell components. The disclosed composition can therefore be universally used for the therapeutic purposes regardless of the origin of the stem cells and/or precursor cells and utilize the natural regenerative potency thereof in a highly efficient manner for replacing tissue, e.g. for a suitable bone and/or cartilage structure. | 2010-04-29 |
20100104642 | HYDROPHILIC FOAM AND PHARMACEUTICAL DOSAGE FORM EMPLOYING THE SAME - Disclosed herein is a hydrophilic foam. The hydrophilic foam includes a polyurethane matrix having a plurality of cells. The cells are capable of retaining water in an amount of least about 8 grams of water per gram of the hydrophilic foam. | 2010-04-29 |
20100104643 | PHARMACEUTICAL COMPOSITIONS - The present invention provides an orally deliverable pharmaceutical composition for the once-daily (OD) administration of trimipramine. The composition comprises a therapeutically effective amount of trimipramine and at least one pharmaceutically acceptable excipient. The compositions of the invention may exhibit one or more of the release profiles defined in this specification. | 2010-04-29 |
20100104644 | Compositions and Methods for Treating or Preventing Ophthalmic Disease - Methods are disclosed for treating or preventing ophthalmic conditions related to a toxic visual cycle product. Compounds and compositions useful in these methods, either alone or in combination with other therapeutic agents, are also described, along with methods of screening for new agents useful in said the therapeutic and prophylactic methods of the invention. | 2010-04-29 |
20100104645 | METHODS FOR THE PREPARATION OF TARGETING AGENT FUNCTIONALIZED DIBLOCK COPOLYMERS FOR USE IN FABRICATION OF THERAPEUTIC TARGETED NANOPARTICLES - This application provides methods of making nanoparticles using pre-functionalized poly(ethylene glycol) (also referred to as PEG) as a macroinitiator for the synthesis of diblock copolymers. These diblock copolymers comprise a poly(ethylene glycol) block bearing a targeting agent at its terminus and a second biocompatible and biodegradable hydrophobic polymer block (e.g. a poly(ester)). The poly(ethylene glycol) is hetero-bifunctional with a targeting moiety (agent) covalently bound to its α terminus and a polymerization initiating functional group (e.g., a hydroxyl group) present on its ω terminus. Ring opening polymerization yields the desired poly(ester)-poly(ethylene glycol)-targeting agent polymer that is used to impart targeting capability to therapeutic nanoparticles. This “polymerization from” approach typically employs precursors of the targeting agent wherein the reactivity of functional groups of the targeting agent is masked using protecting groups. Also described is a “coupling to” that utilized the poly(ethylene glycol)-targeting agent conjugate where the targeting agent remains in its native un-protected form. This method uses “orthogonal” chemistry that exhibit no cross reactivity towards functional groups typically found within targeting agents of interest. Nanoparticles produced according to the disclosed methods as well as their use in the treatment of various diseases are also provided. | 2010-04-29 |
20100104646 | NANOPARTICLE COMPOSITION FOR PREVENTION OF HAIR LOSS AND PROMOTION OF HAIR GROWTH - A nanoparticle composition is provided for preventing hair loss and promoting hair growth. It is based on herbal materials and thus has no harmful side effects on the body. When applied to the scalp, the nanoparticle composition deeply infiltrates into the dermis to promote blood circulation therein and provide nutrients thereto. Accordingly, the nanoparticle composition stimulates and activates hair follicles to thus promote the metabolism of hairs. Also, the nanoparticle composition exerts antioxidant activity on the scalp to thus inhibit depilation and aid in hair regrowth. | 2010-04-29 |
20100104647 | HOLLOW MICROPARTICLES - The invention provides a process for making hollow microparticles. The process comprises providing a dispersion having a continuous aqueous phase and a discontinuous organic phase and polymerising a monomer in the dispersion to form hollow polymeric microparticles. The continuous aqueous phase of the dispersion comprises a stabiliser and the discontinuous organic phase of the dispersion comprises the monomer and an organic liquid. The monomer has two or more polymerisable groups per molecule. Prior to the step of polymerising the monomer, the discontinuous organic phase does not contain a polymer. | 2010-04-29 |
20100104648 | TREATMENT OF INFLAMMATORY AND/OR BACTERIAL CONDITIONS WITH PARTICLES OF MICROSTRUCTURE - The present invention refers to a method for treatment of an inflammatory and/or bacterial condition, wherein particles of microstructure comprising titanium, titanium alloy, at least one titanium oxide or a combination thereof, and having a surface with at least a substantial part consisting of at least one type of titanium oxide, are brought into contact with at least one infected site in a human or animal body by insertion, injection or implantation, which at least one infected site exhibits the inflammatory and/or bacterial condition. Moreover, the present invention refers to an injectable suspension comprising the particles according to the invention and a fluid vehicle for use as a medicament. Finally, the present invention also defines use of the particles of microstructure according to the invention for the manufacture of a medicament in the form of an injectable suspension. Examples of conditions being treated with the injectable suspension according to the present invention are periodontitis, periimplantitis, and osteitis. | 2010-04-29 |
20100104649 | Lercanidipine Hydrochloride Polymorphs and an Improved Process for Preparation of 1,1,N-Trimethyl-N-(3,3-Diphenylpropyl)-2-Aminoethyl Acetoacetate - Disclosed herein is an improved, commercially viable and industrially advantageous process for the preparation of substantially pure Lercanidipine intermediate, 1,1,N-trimethyl-N-(3,3-diphenylpropyl)-2-aminoethyl acetoacetate. The intermediate is useful for preparing Lercanidipine, or a pharmaceutically acceptable salt thereof, in high yield and purity. The present invention further provides a novel crystalline form of Lercanidipine hydrochloride and a process for its preparation. The present invention also provides a process for the preparation of amorphous form of Lercanidipine hydrochloride. | 2010-04-29 |
20100104650 | CHARGED MESOPOROUS SILICA NANOPARTICLE-BASED DRUG DELIVERY SYSTEM FOR CONTROLLED RELEASE AND ENHANCED BIOAVAILABILITY - A charged mesoporous silica nanoparticle (MSN)-based drug delivery system for controlled release and enhanced bioavailability is disclosed. The system comprises a positively charged MSN, which has a silica matrix and an array of pores and/or nanochannels in the matrix. The entire substance of the matrix, all the surfaces and the pores and/or nanochannels comprise a plurality of silanol (Si—OH) and quaternary ammonium functional groups. The bioavailability of a negatively charged bioactive compound can be increased by loading it into the pores and/or nanochannels. The silanol (Si—OH) functional groups on the surfaces lining the walls of the pores and/or nanochannels are free to deprotonate in a fluid having pH above the pI of the positively charged MSN and lead to a sustained release of the negatively charged drug from the pores and/or nanochannels, and thereby enhance the bioavailability of the drug. | 2010-04-29 |
20100104651 | Pharmaceutical Compositions Containing Diacerein - A once-daily controlled-release formulation of diacerein for treating inflammatory or autoimmune diseases or their complications, with reduced adverse side effects and methods of treating such diseases are disclosed. | 2010-04-29 |
20100104652 | Use of advanced nanomaterials for increasing sepecific cell functions - Disclosed herein are methodologies and compositions for enhancing cellular functions, which can be used in a variety of biological applications. | 2010-04-29 |
20100104653 | Nanoparticle-Coated Medical Devices And Formulations For Treating Vascular Disease - Nanoparticle-coated medical devices, nanoparticle-containing formulations and methods of using for treating a vascular disease are disclosed. The method for treating a vascular disease includes providing a formulation comprising a plurality of nanoparticles having a density different from that of blood and further comprising one or more bioactive agents encapsulated within, adhered to a surface of or integrated into the structure of the nanoparticles; and administering a therapeutically effective amount of the formulation to a vascular disease locale in a patient. | 2010-04-29 |
20100104654 | PROSTAGLANDIN AND PROSTAMIDE DRUG DELIVERY SYSTEMS AND INTRAOCULAR THERAPEUTIC USES THEREOF - Biocompatible, bioerodible implants and microspheres include latanoprost and a biodegradable polymer effective, when placed intraocular (such as into the subtenon space) to treat glaucoma. | 2010-04-29 |
20100104655 | Therapeutic Polymeric Nanoparticles Comprising Vinca Alkaloids and Methods of Making and Using Same - The present disclosure generally relates to therapeutic nanoparticles. Exemplary nanoparticles disclosed herein may include about 1 to about 20 weight percent of a vinca alkaloid; and about 50 to about 99 weight percent biocompatible polymer. | 2010-04-29 |
20100104656 | Meltable Binder for Melt Granulation and/or Pelletization - A low melting binder composition for preparation of pharmaceutical tablets and/or granules which comprises a polymer and a hydrophobic meltable binder. | 2010-04-29 |
20100104657 | PHARMACEUTICAL COMPOSITION COMPRISING A REDUCED CONCENTRATION OF CHOLESTEROL - The invention relates to a process for decreasing the amount of cholesterol in a mixture comprising a marine oil, the marine oil containing the cholesterol, which process comprises the steps of adding a volatile working fluid to the mixture, where the volatile working fluid comprises at least one of a fatty acid ester, a fatty acid amide and a hydrocarbon, and subjecting the mixture with the added volatile working fluid to at least one stripping processing step, in which an amount of cholesterol present in the marine oil in free form is separated from the mixture together with the volatile working fluid. The present invention also relates to a volatile cholesterol decreasing working fluid and a health supplement and a pharmaceutical, based on a marine oil, prepared according to the process mentioned above. | 2010-04-29 |
20100104658 | GRAFT PROSTHESIS, MATERIALS AND METHODS - A graft prostheses ( | 2010-04-29 |
20100104659 | BENZOPYRANOPYRAZOLES - Compounds of a certain formula I, in which Ra, Rb and Rc have the meanings indicated in the description, are effective compounds with anti-proliferative and/or apoptosis inducing activity. | 2010-04-29 |
20100104660 | COMPOSITION AND METHOD FOR TREATING TUMOR - Methods for treating neoplasm, tumors and cancers, using one or more tumor treating drug carriers, haptens and anticancer drugs, alone or in combination with other antineoplastic agents or treatments, are provided. Also provided are compositions, and kits containing the composition for affecting the therapy. | 2010-04-29 |
20100104661 | DISCONTINUOUS METHODS OF TREATING CANCER - Disclosed are methods of treating taxane sensitive tumors (i.e., cancers treatable with taxanes) using a taxane and the discontinuous dosing of lonafarnib. | 2010-04-29 |
20100104662 | COMPOSITION AND METHODS FOR MODULATING CELL PROLIFERATION AND CELL DEATH - Described herein are compositions and methods for modulation of p53-dependent cell death and cell proliferation. The compositions are microRNAs and associated nucleic acids. | 2010-04-29 |
20100104663 | REHYDRATION COMPOSITION FOR PREPARING A SOLUTE BY RECONSTITUTION IN WATER - The present invention relates to a rehydration composition intended for the preparation of a solution by reconstitution in water, preferably slightly mineralized water. | 2010-04-29 |
20100104664 | TREATMENT OF CHRONIC RENAL FAILURE AND OTHER CONDITIONS IN DOMESTIC ANIMALS: COMPOSITIONS AND METHODS - The present invention generally concerns the management of age-related diseases in domestic animals. Specifically, the present invention is directed to combination therapies for the treatment of progressive renal diseases (e.g., Chronic Renal Failure) and their accompanying secondary disease states. In a composition aspect, the present invention provides a composition comprising a phosphate binder and another pharmaceutically active ingredient. The other pharmaceutically active ingredient is selected from a group consisting of antihypertensives, calcitrol, vitamin D analogues, lipid restriction products, potassium salts, treatments for anemia and alkalization compounds. | 2010-04-29 |
20100104665 | Methods and Apparatus for Treating Rhinitis - Apparatus and methods deliver treatment agents simultaneously with capnic gases. The capnic gases can enhance the effectiveness of the treatment agent for treating rhinitis, lower the dosage of drug or concentration of agent necessary to achieve a therapeutic result, or both. Exemplary capnic gases include carbon dioxide, nitric oxide, nitrous oxide, and dilute acid gases. | 2010-04-29 |
20100104666 | Animal Repellant & Method of Use Thereof - A new Animal Repellent & Method of Use Thereof which generally comprises a composition of materials or ingredients that combine to create a new and novel animal repellant that is embodied in liquid or granular form, and can be applied as a spray directly to plant parts or sprinkled on or combined with the soil or mulch bed as a granule to discourage activities such as browsing and eating, burrowing and or digging, or general consumption or disruption of a potted plants, planting beds, landscape, garden, or other foliage environment, by animals including but not limited to, squirrels, chipmunks, prairie dogs, gophers, woodchucks, and other members of the order rodentia family not referred to herein, as well as other types of animals such as raccoons, that would otherwise destroy or damage plant material and the surrounding region or soil. | 2010-04-29 |
20100104667 | Conversation of nitrogen dioxide (NO2) to nitric oxide (NO) - A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal. | 2010-04-29 |
20100104668 | NUTRITIONAL SUPPLEMENT FOR HONEYBEES - A nutritional supplement for honeybees includes plant material chosen from a group comprised of plants known to provide nutrients to the honeybees, a beverage brewed from the plant material and a sugar base upon which the beverage is applied where, when the beverage has dried, the nutritional supplement is formed and can be distributed to supplement a normal honeybee feeding thereby providing a more balanced diet that at least in part helps to strengthen immune systems of the honeybees. The group includes plants known to, at least in part, stimulate a queen honeybee to lay eggs, stimulate hygienic behavior in a honeybee colony, provide a preventive maintenance against disease treat and reduce bacteria, fungus and viruses treat and reduce honeybee dysentery, reduce pests in a honeybee colony, such as tracheal and varroa mite and treat and reduce Deformed Wing Virus in a honeybee colony. | 2010-04-29 |
20100104669 | Method for preparing an aqueous solution containing triterpenic acid, aqueous solution containing triterpenic acid, and use thereof - A method for preparing an aqueous solution containing triterpenic acid, an aqueous solution containing triterpenic acid, and use thereof, includes preparation of a basic aqueous solution containing triterpenic acid and reduction of the pH of the basic aqueous solution containing triterpenic acid by adding an acidic aqueous solution in the presence of a stabilizing additive. The system may also provide an aqueous physiological solution of a plant extract containing triterpenic acid, a method for preparing same, and use thereof for therapeutic purposes that includes aqueous physiological solutions rich in triterpenic acid which includes pharmacologically effective amounts of triterpenic acids. | 2010-04-29 |
20100104670 | USE OF CHITOSANS FOR THE TREATMENT OF NAIL INFLAMMATORY DISEASES - Chitosan-based nail formulations are useful to treat nail inflammatory diseases like psoriasis, atopic dermatitis and | 2010-04-29 |
20100104671 | COSMETIC AND/OR PHARMACEUTICAL COMPOSITIONS AND THEIR APPLICATIONS - Compositions are disclosed containing, as active ingredients, an extract of | 2010-04-29 |
20100104672 | GEL-TYPE BIRD AVERSION COMPOSITIONS - A gel-type bird aversion composition consists of, on the basis of weight, 30 to 90% of a thickening agent, 0.01 to 4% of an ultraviolet ray absorbent, 0.1 to 20% of methyl anthranilate, 0.1 to 10% of cinnamon essential oil, 0.1 to 20% of mint essential oil; 5 to 40% by weight of mineral oil or grease; and 1 to 10% by weight of emulsifier. | 2010-04-29 |
20100104673 | Methods and Compositions for Treatment of Skin Conditions - Topical skin care compositions are described that include effective amounts of anti-inflammatory, antioxidant, silica and sugar compounds. In addition, methods of treating skin conditions are described, which include applying topically to a site of treatment a therapeutically effective amount of a composition comprising anti-inflammatory, antioxidant, silica and sugar compounds. | 2010-04-29 |
20100104674 | COMPOSITION FOR THE TREATMENT OF HYPERTENSION - The present invention is directed to a composition for the treatment of hypertension and/or of the symptoms associated with hypertension and/or of diseases caused by hypertension. | 2010-04-29 |
20100104675 | Method Of Treating Demyelinating Central Nervous System Diseases - The invention provides a method of treating a subject afflicted with a disease associated with demyelination of the central nervous system comprising administering to the subject a therapeutically effective amount of any of a composition containing | 2010-04-29 |
20100104676 | APPARATUS FOR COOLING TIRE AFTER VULCANIZATION - The invention aims to provide a vulcanized tire cooling apparatus configured to blow cooling air to a vulcanized tire in rotation, thereby achieving uniform cooling of the vulcanized tire and shortening of cooling time as well as preventing the vulcanized tire from being deformed due to centrifugal force. It includes a blower unit ( | 2010-04-29 |
20100104677 | Device for Producing Blown Films - A device for producing blown films, including an extrusion device generating a tubular film and a flattening device, associated with the tubular film, having two flattening elements, arranged on diametrically opposite zones of the tubular film and adjustable in relation to each other at an acute angle, for transforming a cross-section of the tubular film, which is first circular, then oval, to a double-layer film web. This invention has lateral guide elements for the areas of the tubular film that are not affected by the flattening elements and are arranged between the flattening elements and are associated with the tubular film and the lateral guide elements have an adjustable contour. | 2010-04-29 |
20100104678 | APPARATUS AND METHOD FOR MAKING AND USING A TOOLING DIE - A method of making a tooling die can include depositing a plurality of layers onto a substrate using a printing process. Selected portions of the plurality of layers can be removed to expose a surface defining a desired shape of the tooling die. An electrically conductive material can be deposited to form a seed layer, and a structural material can be electrodeposited onto the seed layer to form the tooling die. The tooling die can be used to form contact structures on an electronic component. | 2010-04-29 |
20100104679 | AUTOMATIC GATHERING PRE-SHAPE MACHINE - An automatic gathering pre-shape machine has a main body and a gathering device. The main body can make plastic films formed into a circular shape with an annular flange formed around a top edge of the film. The gathering device allows a pre-shaped plastic film be blown toward an outer end of the barrel to hit a block wall and drop and mount around a tip portion of corresponding shelf to be gathered. Consequently, the plastic film may easily and automatically be gathered from the main body. Therefore, the plastic films can be kept from being damaged and the pre-shaping process is accelerated. | 2010-04-29 |
20100104680 | FOOD PROCESSOR WITH PHONETIC RECOGNITION ABILITY - A food processor with phonetic recognition ability is disclosed, which comprises: a phonetic recognition module and a food processing module. The phonetic recognition module is capable of receiving sound signals so as to identify a content of characters containing in the received sound signals. The food processing module is capable of producing food products containing characters corresponding to the phonetic recognition result of the phonetic recognition module. | 2010-04-29 |
20100104681 | BLOW-MOLD ASSEMBLY FOR THE MANUFACTURING OF CONTAINERS, INCLUDING A MOLD AND A PLUG FOR FLUID CONNECTION - A Blow-mold assembly for the manufacturing of containers, comprising:
| 2010-04-29 |
20100104682 | IMPRINTING DEVICE - An optical imprinting device capable of simultaneously imprinting fine patterns to both surfaces of an opaque substrate is provided. The imprinting device includes a stamper having a fine pattern on its surface to imprint the fine pattern onto a surface of an object to be imprinted by pressing the stamper against the object composed of a substrate and a photo-curing resin layer formed on the substrate. The imprinting device further includes a light source for applying light to the photo-curing resin layer of the object when imprinting the fine pattern of the stamper onto the photo-curing resin layer of the object. The light source applies light to the stamper at a predetermined incident angle to the surface of the stamper. | 2010-04-29 |
20100104683 | MOLDING DEVICE FOR PRE-SHAPED PLASTIC FILMS - A molding device for pre-shaped plastic films has a body, a platform and a driving shaft. The body can be rotatably mounted in a pre-shape machine and has an annular side surface and a top opening. The platform is detachably mounted in the top opening of the body. The driving shaft is mounted longitudinally through the body, movably extends longitudinally relative to the body and has an end attached securely to the platform to selectively raise the platform to lift a pre-shaped plastic film from the body. Accordingly, the plastic films can easily be separated from the platform, and to manually separate the plastic film from the molding device is unnecessary to prevent the plastic films from being damaged. | 2010-04-29 |
20100104684 | PRODUCTION MACHINE WITH MACHINE PANELLING - The production machine has functional elements which are arranged inside machine paneling ( | 2010-04-29 |
20100104685 | Device for processing elastomers and/or thermoplastics - A device for processing elastomers or thermoplastics has a distribution system that is disposed between a plasticizing unit and an injection-molding die for distribution of the material plasticized in the plasticizing unit. At least one nozzle is disposed on the distribution system, by way of which nozzle the plasticized elastomer can be injected into the cavity of the injection molding die. The at least one nozzle is attached outside the center on a rotating insert, in each instance, which insert is disposed in a recess in the distribution system. | 2010-04-29 |
20100104686 | Nutritional Composition To Promote Healthy Development And Growth - A nutritional composition including a lipid or fat; a protein source; at least about 5 mg/100 kcal of a source of long chain polyunsaturated fatty acids which comprises docosahexanoic acid; and at least about 0.2 mg/100 kcal of a prebiotic composition, wherein the prebiotic composition comprises a plurality of oligosaccharides such that the overall fermentation rate profile of the prebiotic composition provides an increased population of beneficial bacteria in the human gut over an extended period of time. | 2010-04-29 |
20100104687 | SEGMENTED CONFECTIONERY PRODUCTS - A confectionery article adapted for accurate division of a confectionery article into two or more smaller portions, which confectionery article has two or more segments having different compositions. | 2010-04-29 |
20100104688 | Chewing Gum Granules For Compressed Chewing Gum - A chewing gum granule containing gum base, wherein the chewing gum granule is substantially ball-shaped, the chewing gum granule has an average diameter below 1900 μm, and wherein the surface of the chewing gum granule is provided with 0.5 to 18% by weight of free-flowing agent. With the present invention improved free-flow properties of the chewing gum granules may be obtained. | 2010-04-29 |
20100104689 | Compressed Chewing Gum Comprising An Encapsulation Delivery System Comprising Natural Resin - A compressible chewing gum composition includes i) chewing gum granules containing gum base and ii) particles of one or more encapsulation delivery systems including at least one encapsulation material and at least one active ingredient being encapsulated by the encapsulation material, wherein the encapsulation material includes at least one natural resin. The compressible chewing gum composition, which has been provided, is suitable for compression into compressed chewing gum tablets. Such compressed chewing gum tablets thus include a compression of a quantity of the compressible chewing gum composition and thus include chewing gum granules containing gum base and particles of one or more encapsulation delivery systems including an active ingredient encapsulated by an encapsulation material including natural resin. | 2010-04-29 |
20100104690 | Tagged Microorganisms and Methods of Tagging - The present invention provides methods for tagging and/or identifying microorganisms. In some preferred embodiments, the microorganisms are bacteria. In some particularly preferred embodiments, the bacteria are members of the genus | 2010-04-29 |
20100104691 | METHOD AND EQUIPMENT FOR THE CONTINUOUS PRODUCTION OF AN EXPANDED FOOD PRODUCT - The invention relates to a method for the continuous production of an expanded edible food product obtained by cooking-extrusion and containing solid inclusions having a size larger than 0.5 mm. | 2010-04-29 |
20100104692 | FLOUR BASED DOUGH AND METHOD OF PREPARING SUCH DOUGH - A method of preparing a flour based dough, includes mixing flour, a source of water-unextractable (WU) arabinoxylans, xylanase and water, wherein the source of WU arabinoxylans includes at least 10% WU arabinoxylans by weight of dry matter and the source of WU arabinoxylans is applied in an amount sufficient to deliver at least 2.5 g of WU arabinoxylans per kg of flour. The combined use of WU arabinoxylans and xylanase yields a dough product that exhibits improved processability, excellent proof stability and very high bake volume. Also disclosed is a flour based dough containing:
| 2010-04-29 |
20100104693 | HIGH FIBER SHELF STABLE TOASTER PASTRIES AND METHODS OF PREPARATION - Icing coated shelf stable high fiber toaster pastry product or packaged consumer food articles are provided as well as their methods of preparation comprising high levels of a soluble fiber ingredient partitioned between the shell, filling and the icing. The present articles comprise an homogeneous baked chemically leavened soluble fiber fortified pastry dough planar shell forming an interior. The fiber fortified dough includes whole grain wheat flour; salt, chemical leavening, shortening, and ≈1-15% added solid powdered polydextrose and in amounts sufficient to provide a total fiber content of the dough of at least 5%. At least a portion of the chemical leavening is provided by ammonium carbonate and in amounts sufficient to provide the dough with a specific baked volume of 1.5 cc/g or greater. The filling includes a liquid soluble fiber ingredient such as polydextrose. The articles are equivalent to conventional toaster pastries in eating qualities notwithstanding their high levels of total fiber. | 2010-04-29 |
20100104694 | Process for Producing a Glyceride Composition - A process for the production of a composition comprising 1,3-dioleoyl-2-palmitoyl glyceride (OPO) comprises: providing one or more palm oil stearin fractions comprising tripalmitoyl glyceride and having an iodine value between about 18 and about 40; interesterifying the one or more palm oil stearin fractions to form a randomly interesterified palm oil stearin; subjecting the randomly interesterified palm oil stearin to enzymic transesterification with oleic acid or a non-glyceride ester thereof using an enzyme having selectivity for the 1- and 3-positions of a glyceride; and separating palmitic acid or palmitic non-glyceride esters from the product obtained in (iii) to form a composition comprising OPO glyceride. | 2010-04-29 |
20100104695 | INSTANT BEVERAGE CUBES - A solid cube is provided that is dissolved in water or milk to produce a beverage. The solid cube is formed using pulverized Panela (of common use in Colombia) freeze-dried beverage materials such as coffee and artificial flavors as basic ingredients. The solid cube is prepared by mixing the ingredients in a dry atmosphere and shaping them to the desired size and shape using a non-stick mold and compression molding techniques. | 2010-04-29 |
20100104696 | Nutritional Composition With Improved Digestibility - The present invention is directed an improved nutritional composition, methods of improving digestion, and methods of enhancing the bioavailability of TGF-β. | 2010-04-29 |