16th week of 2015 patent applcation highlights part 38 |
Patent application number | Title | Published |
20150104796 | System comprising at least two laboratory instruments for instrument-controlled handling of a partial problem in a treatment process containing treatments of at least one laboratory sample, laboratory instrument and method - The invention relates to a laboratory instrument for the instrument-controlled handling of a partial problem in a treatment process which contains treatments of at least one laboratory sample. The invention moreover relates to a system containing a plurality of such laboratory instruments, wherein the system serves for the instrument-controlled handling of a problem containing a plurality of these partial problems in the treatment process of at least one laboratory sample. And the invention relates to a method for the instrument-controlled handling of a partial problem in a treatment process which contains treatments of at least one laboratory sample. | 2015-04-16 |
20150104797 | COMPOSITE VISIBLE COLORANT AND METHOD FOR QUANTITATIVE AMPLIFICATION - Methods and compositions for using colorants with real-time amplification reactions and normalization passive dyes are provided. | 2015-04-16 |
20150104798 | MICRODROPLET-MANIPULATION SYSTEMS AND METHODS FOR AUTOMATED EXECUTION OF MOLECULAR BIOLOGICAL PROTOCOLS - Disclosed herein are automated systems for performing various biochemical and molecular biological procedures, including processor-controlled execution of protocols involving multiple steps performed in, on, or with liquid microdroplets. Example protocols are the various Polymerase Chain Reaction (PCR) protocols, but the subject systems are not limited to performing PCR protocols. Formation of a microdroplet of the sample for use in the described systems is achieved by bringing an amount of the sample into contact with a hydrophobic milieu, such as a superhydrophobic surface or hydrophobic liquid. | 2015-04-16 |
20150104799 | DNA-Based Detection and Identification of Eight Mastitis Pathogens - LAMP primer sets for detecting eight mastitis pathogens are disclosed. Methods and kits of using the primer sets to simultaneously detecting at least two of the eight mastitis pathogens are also described. | 2015-04-16 |
20150104800 | SYSTEM AND METHOD FOR MARKING TEXTILES WITH NUCLEIC ACIDS - A method for authenticating a textile material that is initiated by selecting a unique nucleic acid marker having a specific length and a specific sequence. A media that causes the unique nucleic acid marker to adhere to a fibrous material is then selected. The method then proceeds to generate a nucleic acid marker mixture by mixing the media with the nucleic acid marker. The nucleic acid marker mixture is then applied to the fibrous material. A marked fibrous material is produced by marking the fibrous material with the nucleic acid marker. The textile material is manufactured with the marked fibrous material. The textile material is then authenticated by detecting the unique nucleic acid marker with primers that are specific to the unique nucleic acid. | 2015-04-16 |
20150104801 | METHODS AND COMPOSITIONS FOR EXOSOME ISOLATION - Disclosed are methods, compositions and kits for the isolation of exosomes from biological fluids and tissues. Volume-excluding polymers are used to precipitate exosomes from biological samples thereby allowing exosome isolation by low-speed (benchtop) centrifugation or filtration. Further fractionation of exosomes after precipitation is also described. | 2015-04-16 |
20150104802 | SYSTEMS AND METHODS FOR DEVELOPING QUANTIFIABLE MATERIAL STANDARDS FOR FEEDSTOCKS AND PRODUCTS USED IN ADDITIVE MANUFACTRUING PROCESSES - Methods and systems for enabling additive manufacturing feedstock materials to communicate with supervisory control and data acquisition (SCADA) systems by way of molecular markers. Markers can be DNA encoded with information or other small molecules that emit a biochemical, chemical, fluorescent, or conductive signal; markers also include additives that transmit empirical data about resistivity, density, weight, volumetric information or other properties of the 3D printed object. The methods to inject materials with markers are to use various solvents or integration as a dry formulation, blended by weight, and concentration. Markers can be applied to feedstock materials entirely, or integrated at various locations on a 3D-printed object while it is being printed or as a thin layer while the object undergoes post-processing treatment. | 2015-04-16 |
20150104803 | COMPOSITIONS AND METHODS FOR OBTAINING NUCLEIC ACIDS FROM SPUTUM - The present invention relates to compositions and methods for preserving and extracting nucleic acids from saliva. The compositions include a chelating agent, a denaturing agent, buffers to maintain the pH of the composition within ranges desirable for DNA and/or RNA. The compositions may also include a reducing agent and/or antimicrobial agent. The invention extends to methods of using the compositions of the invention to preserve and isolate nucleic acids from saliva as well as to containers for the compositions of the invention. | 2015-04-16 |
20150104804 | Method for Manufacturing Cubic Diamond Nanocrystals - A method for manufacturing cubic diamond nanocrystals (10) comprising the following successive steps:
| 2015-04-16 |
20150104805 | ASSAY FOR TRICHOMONAS VAGINALIS BY AMPLIFICATION AND DETECTION OF TRICHOMONAS VAGINALIS AP65-1 GENE - A region of the | 2015-04-16 |
20150104806 | Parkinson's Disease Biomarker - The present invention relates to a biomarker for Parkinson's disease. The biomarker and products associated with the biomarker may be used to assist diagnosis or to assess onset and/or development of Parkinson's disease. The invention also relates to use of the biomarker in clinical screening, assessment of prognosis, evaluation of drug treatments, drug screening or drug development in the field of Parkinson's disease and Parkinson's disease related disorders. | 2015-04-16 |
20150104807 | KITS FOR DIAGNOSTIC AND THERAPEUTIC USES OF AUGMENTER OF LIVER REGENERATION IN INFLAMMATORY CONDITIONS - The present invention provides for methods and kits for detecting sepsis, trauma/hemorrhage or inflammation in a subject. It is based, at least in part, on the discovery that Augmenter of Liver Regeneration (“ALR”) is an early marker of these conditions. Accordingly, in other embodiments, the present invention provides for a method of treating sepsis, traumatic/hemorrhagic shock and inflammation by inhibiting ALR. | 2015-04-16 |
20150104808 | Cysteine Engineered Fibronectin Type III Domain Binding Molecules - Cysteine engineered monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules comprising one or more free cysteine amino acids are prepared by mutagenizing a nucleic acid sequence of a parent molecule and replacing one or more amino acid residues by cysteine to encode the cysteine engineered FN3 domain containing monospecific or bispecific molecules; expressing the cysteine engineered FN3 domain containing molecules; and recovering the cysteine engineered FN3 domain containing molecule. Isolated cysteine engineered monospecific or bispecific FN3 domain containing molecules may be covalently attached to a detection label or a drug moiety and used therapeutically. | 2015-04-16 |
20150104809 | DETECTION AND TREATMENT OF CANCER - The present invention relates to a method for diagnosing, evaluating the prognosis of a cancer patient and evaluating the aggressiveness of a cancer. The methods comprise detecting the phosphorylation status of a Scribble protein, a fragment or variant thereof, wherein the phosphorylation status is indicative of cancer, prognosis and the aggressiveness of a cancer. In one embodiment the cancer is breast cancer. | 2015-04-16 |
20150104810 | LATERAL FLOW STRIP ASSAY WITH IMMOBILIZED CONJUGATE - The present invention discloses analyte detection devices for detecting one or more analytes present in test samples, especially biological samples. In particular, the devices of the invention are lateral flow assay devices comprising immobilized metal nanoparticle conjugates as the detection means. Methods of using the devices and kits comprising the devices are also described. | 2015-04-16 |
20150104811 | METHOD FOR PRETREATING BIOLOGICAL SAMPLE CONTAINING PROTEIN - The present invention provides a method for pretreatment of a biological sample in the immunoassay of a protein contained in the biological sample. The method includes the steps of: (1) freezing the biological sample at a temperature higher than −80° C., in particular at −70° C. or higher; (2) thawing the frozen biological sample; and (3) solubilizing the biological sample using a surfactant. | 2015-04-16 |
20150104812 | MICRO-ENGINEERED HYDROGELS - A polyacrylamide hydrogel includes co-polymerized acrylamide, bisacrylamide and N-hydroxyethylacrylamide | 2015-04-16 |
20150104813 | MATERIALS AND METHODS FOR EVALUATING AND TREATING NEUROMYELITIS OPTICA (NMO) - The invention provides prognostic methods for evaluating the severity of NMO and NMO-associated diseases as well as methods of treating NMO and NMO-associated diseases. | 2015-04-16 |
20150104814 | SAMPLE ANALYSIS METHODS AND APPARATUSES AND DYNAMIC VALVE OPERATION METHODS - Disclosed are sample analysis apparatus and methods. A sample analysis apparatus includes a first unit that rotates a microfluidic apparatus including: a chamber having a space accommodating a sample, a channel that provides a path through which the sample flows; and a valve that selectively opens and closes the channel, a valve driver that supplies energy, used to operate the valve, to the valve in a state of being separated from the microfluidic apparatus, a third unit that rotates the valve driver with respect to a common rotation axis with a rotation axis of the microfluidic apparatus and the third unit, and a control unit that controls the first and third units and the valve driver to supply energy to the valve while the microfluidic apparatus and the valve driver are being rotated at the same rotation speed. | 2015-04-16 |
20150104815 | Porphyrin-Lipid Stabilized Nanoparticles for Surface Enhanced Raman Scattering Based Imaging - Herein are provided nano-particles comprising a nanocore of Raman-scattering material stabilized by a bilayer comprising a porphyrin-phospholipid conjugate, methods of making the same and their use in Surface Enhanced Raman Scattering. | 2015-04-16 |
20150104816 | MARKER FOR DETECTING PANCREATIC CANCER - A marker for detecting pancreatic cancer, said marker comprising a glycoprotein C4BPA or PIGR, whereby a pancreatic cancer patient can be distinguished from a chronic pancreatitis patient or a normal subject and thus specifically diagnosed. Also, the marker is usable in monitoring the postoperative prognosis of a pancreatic cancer patient. When the aforesaid marker is used in combination with another pancreatic cancer marker such as CA19-9, furthermore, a pancreatic cancer patient can be distinguished from a chronic pancreatitis patient or a normal subject and diagnosed more specifically. | 2015-04-16 |
20150104817 | HYDROXYCHOLESTEROL IMMUNOASSAY - Provided is a derivative of 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. Also provided is a protein conjugated to the above derivative. Further provided is an antibody composition comprising antibodies that specifically bind to 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. Additionally, a method of making antibodies that specifically bind to 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Also, a method of assaying for 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Additionally provided is a kit for detecting 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. A method of detecting an enzyme or enzymes utilized in phase II drug metabolism is also provided. Also, a method of detecting an enzyme that synthesizes 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Further provided is a method of evaluating progression of multiple sclerosis in a patient. Also provided is a method of determining whether a treatment for multiple sclerosis in a patient is effective. Further, a method of evaluating progression of Huntington's disease in a patient is provided. Additionally provided is a method of determining whether a treatment for Huntington's disease in a patient is effective. | 2015-04-16 |
20150104818 | GEMCITABINE IMMUNOASSAY - The present invention comprises novel conjugates and immunogens derived from gemcitabine and unique antibodies generated by using gemcitabine linked immunogens, which conjugates immunogens and antibodies, are useful in immunoassays for the quantification and monitoring of gemcitabine in biological fluids. | 2015-04-16 |
20150104819 | METHODS OF USING ISONIAZID FOR THE DIAGNOSIS OF LUNG INFECTIONS - The present invention is directed to methods of diagnosing the presence or absence of a bacterial infection in a patient, in particular, a tuberculosis infection, by measuring exhaled, isotopically labeled nitrogen gas after administration of isotopic ally labeled isoniazid. | 2015-04-16 |
20150104820 | METHOD FOR PRODUCTION OF EOSINOPHIL FROM PLURIPOTENT STEM CELL - The present invention relates to a method for producing human eosinophils from human pluripotent stem cells. More specifically, the present invention provides a method for producing human eosinophils from human pluripotent stem cells, which method comprises the steps of: (1) co-culturing, in the presence of VEGF, human pluripotent stem cells with cells separated from the AGM region of a mammalian fetus; (2) performing suspension culture using a medium comprising IL-3, IL-6, Flt3 ligand, SCF, TPO and serum; (3) performing suspension culture using a medium comprising IL-3, SCF, GM-CSF and serum; and, optionally, (4) performing suspension culture using a medium comprising IL-3, IL-5 and serum. | 2015-04-16 |
20150104821 | Device and Method for Sorting and Labeling of Biological Systems based on the Ionic-Electric Dynamics - The present invention relates to a method and a device for creating digital copies of the ionic-electric dynamics of cells or cell compartments, such as organisms, or an at least partly identifying dataset that allows sorting decisions in vitro and in vivo. Sorting of cells and cell compartments based on electrical cell behavior can be applied, for instance, to transgenic compartments, in order to, e.g., detect the successful expression of certain channel proteins in an industrial process, to screen for (side) effects of certain agents or substances on the ionic-electrical cell behavior and involved proteins. In that context, the invention can be used as an alternative to complex and/or time consuming patch-clamp screenings as well as for general quality control reasons. | 2015-04-16 |
20150104822 | YEAST STRAINS CAPABLE OF METABOLIZING XYLOSE AND RESISTANT TO INHIBITORS, METHOD FOR OBTAINING SAME AND USE THEREOF - The subject matter of the present invention is novel yeast strains capable of metabolizing xylose and resistant to at least one fermentation inhibitor, and also to the method of obtaining same. The subject of the present invention is also the yeasts obtained by culturing said yeast strains and the use thereof for producing at least one fermentation product, preferably ethanol, in particular in a culture medium comprising xylose and at least one fermentation inhibitor. | 2015-04-16 |
20150104823 | COMPOSITION AND METHOD FOR MEASURING THALLIUM INFLUX AND EFFLUX - The present invention relates to methods for detecting the activity of an ion channel in a cell. The methods comprise providing a loading buffer solution to a cell that has an ion channel. The loading buffer comprises at least one thallium indicator (e.g., an environmentally sensitive, luminescent dye) and a physiological concentration of chloride ions. The methods further comprise providing a stimulus buffer to the cell, wherein the stimulus buffer comprises thallium (e.g., thallium ions). Providing the stimulus buffer causes thallium influx into the cell through the ion channel. After providing the stimulus buffer, the luminescence (e.g., fluorescence) of the dye in the cell is detected. The luminescence of the dye can change in the presence or absence of thallium. The methods may be used to measure influx or efflux of thallium through an ion channel. | 2015-04-16 |
20150104824 | Fixed Chamber Separator With Adjustment Withdrawal Member - A separation device that can include a separation tube or container that has a wall defining an internal volume into which a material can be placed is disclosed. The material can include a multi-component mixture or solution. A secondary tube or withdrawal cannula can be placed and/or moved within the tube to withdrawal a material form the tube. | 2015-04-16 |
20150104825 | CAPTURE, DISRUPTION, AND EXTRACTION APPARATUS AND METHOD - A cell capture, disruption, and extraction apparatus includes a disruption chamber configured to receive cell solution and having therein a plurality of abrasives, which can include diamond powder, variably and multi dimensionally disbursed therein, and a pestle positioned in the disruption chamber. The apparatus includes an actuation device configured to agitate the disruption chamber and/or pestle, movement of the abrasives tearing cell structure in the solution to access its contents. A binding column or size exclusion column can be positioned downstream of the disruption chamber. The pestle can rotate with respect to the disruption chamber. The pestle can include a nut-shaped core or axle, and/or include a plurality of extrusions. Cell solution can first be introduced in the disruption chamber, the abrasives capturing the cells and allowing therethrough and purging the waste content, then breaking the cell content through the foregoing agitation process. The lysate can then bind to an extraction matrix downstream of the disruption chamber or it can be mixed in with the abrasives. | 2015-04-16 |
20150104826 | DEVICES AND CARTRIDGES FOR EXTRACTING BIO-SAMPLE REGIONS AND MOLECULES OF INTEREST - Methods, devices, and systems for integrating extraction and purification of bio-sample regions and materials with patient analysis, diagnosis, follow up, and treatment. The invention provides a means to insert disclosed substrates, cartridges, and cartridge-processing instrument or instruments into a standard clinic or pathology laboratory workflow. Specifically, we disclose methods, devices, and systems for inserting standard pathology slides into disclosed cartridges and cartridge-processing instruments, either manually, semi-automatically, automatically, or by robotic means. | 2015-04-16 |
20150104827 | SCALABLE FERMENTATION PROCESS - This invention provides a robust fermentation process for the expression of a capsid protein of a bacteriophage which is forming a VLP by self-assembly, wherein the process is scalable to a commercial production scale and wherein the expression rate of the capsid protein is controlled to obtain improved yield of soluble capsid protein. This is achieved by combining the advantages of fed-batch culture and of lactose induced expression systems with specific process parameters providing improved repression of the promoter during the growth phase and high plasmid retention throughout the process. | 2015-04-16 |
20150104828 | Levels and/or Sustainability of DNA-based Gene Expression - The invention encompasses methods for improving the level and/or sustainability of expression for a target nucleic acid in a eukaryotic cell comprising: (a) modifying the target nucleic acid to introduce or to comprise signals that limit or constrain the positions of nucleosome cores, and (b) introducing the modified target nucleic acid into the eukaryotic cell, wherein the modified target nucleic acid has improved levels and/or sustainability of expression compared to original unmodified nucleic acid. | 2015-04-16 |
20150104829 | Labeled Biomolecular Compositions and Methods for the Production and Uses Thereof - Disclosed herein is a set of | 2015-04-16 |
20150104830 | AVIAN CELL LINE AND ITS USE IN PRODUCTION OF PROTEIN - The invention provides a process for generating an avian cell line of duck origin by a process comprising: —cultivating embryonic avian cells in cell culture medium, preferably comprising fetal calf serum (FBS) for more than 40 passages while reducing the concentration of FBS to 1-2% vol/vol FBS, —transferring passaged cells into cell culture medium having 0% FBS, —resulting in the generation of a non-embryonic avian cell line suitable for non-adherent growth, i.e. for growth in suspended culture. | 2015-04-16 |
20150104831 | Antibodies and Uses Thereof - The present invention provides antibodies which bind to an epitope in the extracellular domain of human CC chemokine receptor 4 (CCR4) and which are capable of inhibiting the binding of macrophage-derived chemokine (MDC) and/or thymus and activation regulated chemokine (TARC) to CCR4. Also provided are inter alia immunoconjugates and compositions comprising such antibodies and methods and uses involving such antibodies, particularly in the medical and diagnostic fields. | 2015-04-16 |
20150104832 | METHOD FOR MODULATING GENE EXPRESSION BY MODIFYING THE CPG CONTENT - The invention relates to nucleic acid modifications for a directed expression modulation by the targeted insertion or removal of CpG dinucleotides. The invention also relates to modified nucleic acids and expression vectors. | 2015-04-16 |
20150104833 | NOVEL PROTEIN HAVING B-GLUCOSIDASE ACTIVITY AND USES THEREOF - By combination of hydrophobic chromatography and strongly basic anion-exchange chromatography, a novel, highly hydrophobic β-glucosidase was successfully identified from | 2015-04-16 |
20150104834 | Culture Medium and Methods for Producing Alginate From Stable Mucoid Strains of Pseudomonas Aeruginosa - A specialized culture medium for the promotion of alginate production by stable mucoid | 2015-04-16 |
20150104835 | STATIC SOLID STATE BIOREACTOR AND METHOD FOR USING SAME - A static solid state bioreactor and method of using same. The bioreactor comprises a vessel having an upper end and a lower end, the upper end having a sealable opening. A gas distribution system in communication with the upper end and the lower end of the vessel. A liquid distribution system in communication with the upper end of the vessel. A liquid recovery system in communication with the lower end of the vessel. A material removal system disposed at the lower end of the vessel for removing biomass from the vessel. | 2015-04-16 |
20150104836 | METHOD OF PRODUCING L-AMINO ACIDS - Provided is a method of producing | 2015-04-16 |
20150104837 | GENES ENCODING BIOFILM FORMATION INHIBITORY PROTEINS AND A METHOD FOR PRODUCING L-LYSINE USING A BACTERIAL STRAIN WITH THE INACTIVATED GENES - The present invention relates to a novel isolated gene (polynucleotide) which encodes a protein having a biofilm formation inhibitory activity derived from | 2015-04-16 |
20150104838 | RECOMBINANT MICROORGANISM HAVING IMPROVED PUTRESCINE PRODUCING ABILITY AND METHOD FOR PRODUCING PUTRESCINE BY USING SAME - The present invention relates to a recombinant microorganism having enhanced ability of producing putrescine at high yield, which is generated by weakening the activity of NCgl1469 in a microorganism of | 2015-04-16 |
20150104839 | POWDERY LIPASE PREPARATION, METHOD FOR PRODUCING THE SAME AND USE THEREOF - The present invention discloses a powdery lipase preparation which is a granulated material comprising a lipase derived from | 2015-04-16 |
20150104840 | METHOD OF CONTINUOUS FERMENTATION PROCESS FOR SUCCINIC ACID BY MICROBIAL CELLS OF ACTINOBACILLUS SUCCINOGENES - The present invention relates to a continuous fermentation process using | 2015-04-16 |
20150104841 | Genes Related to Xylose Fermentation and Methods of Using Same for Enhanced Biofuel Production - The present invention provides isolated gene sequences involved in xylose fermentation and related recombinant yeast which are useful in methods of enhanced biofuel production, particularly ethanol production. Methods of bioengineering recombinant yeast useful for biofuel production are also provided. | 2015-04-16 |
20150104842 | FUEL COMPOSITIONS CONTAINING LIGNOCELLULOSIC BIOMASS FERMENTATION PROCESS SYRUP - A solid lignocellulosic fuel composition is produced from combining the syrup co-product of a lignocellulosic biomass fermentation process and an additional fuel component. The syrup is an excellent binder for a powdery fuel material that is not readily handled. The fuel composition is further processed to form briquettes, pellets and the like. | 2015-04-16 |
20150104843 | PROCESSING BIOMASS - Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems can use feedstock materials, such as cellulosic and/or lignocellulosic materials and/or starchy or sugary materials, to produce ethanol and/or butanol, e.g., by fermentation. | 2015-04-16 |
20150104844 | MATERIALS FOR MAGNETIZING CELLS AND MAGNETIC MANIPULATION - A material comprising positively and negatively charged nanoparticles, wherein one of said nanoparticles contained a magnetically responsive element, are combined with a support molecule, which is a long natural or synthetic molecule or polymer to make a magnetic nanoparticle assembly. When the magnetic nanoparticle assembly is combined with cells, it will magnetize those cells. The magnetized cells can then be washed to remove the magnetic nanoparticle assembly and the magnetized cells manipulated in a magnetic field. | 2015-04-16 |
20150104845 | ACOUSTIC MANIPULATION PROCESS AND ACOUSTIC MANIPULATION DEVICE - An acoustic manipulation process and acoustic manipulation device are disclosed. The acoustic manipulation process includes providing a device having a pathway positioned to receive a flow of a particle-containing fluid, transporting the particle-containing fluid into the pathway, and applying standing surface acoustic waves to the particle-containing fluid while the particle-containing fluid is flowing through the pathway. The applying of the standing surface acoustic waves to the particle-containing fluid includes nodes and anti-nodes of the standing surface acoustic waves extending through the particle-containing fluid. The acoustic manipulation device includes a pathway positioned to receive a flow of a particle-containing fluid, and a mechanism for generating and applying standing surface acoustic waves to the particle-containing fluid while the particle-containing fluid is flowing through the pathway. | 2015-04-16 |
20150104846 | METHOD FOR PRESERVING COMPONENTS OF PANCREATIC JUICE IN A SAMPLE, AND KIT FOR PRESERVING COMPONENTS OF PANCREATIC JUICE IN A SAMPLE - The present invention provides a method for preserving biological components in pancreatic juice, and a kit suited for this method. The method involves adding, to a pancreatic juice-containing biological sample, at least one sulfonyl fluoride-containing protease inhibitor and at least one trypsin-like serine protease inhibitor belonging to a group of amino acid chloromethyl ketones. | 2015-04-16 |
20150104847 | METHOD FOR STABILIZING CHOLESTEROL OXIDASE - The present invention provides a method for stabilizing a cholesterol oxidase, a method for preserving a cholesterol oxidase, and a stabilized composition of cholesterol oxidase. A method for stabilizing a cholesterol oxidase and a method for preserving a cholesterol oxidase which comprises allowing the cholesterol oxidase to coexist with an α-keto acid in an aqueous medium, and, a stabilized composition of cholesterol oxidase which comprises the cholesterol oxidase being allowed to coexist with an α-keto acid in an aqueous medium. The method for stabilizing a cholesterol oxidase, the method for preserving a cholesterol oxidase, and a stabilized composition of cholesterol oxidase according to the present invention are useful for clinical diagnosis such as metabolic syndrome. | 2015-04-16 |
20150104848 | NUCLEIC ACID-FREE THERMOSTABLE ENZYMES AND METHODS OF PRODUCTION THEREOF - The present invention provides thermostable enzymes, such as DNA polymerases and restriction endonucleases, that are substantially free from contamination with nucleic acids. The invention also provides methods for the production of these enzymes, and kits comprising these enzymes which may be used in amplifying or sequencing nucleic acid molecules, including through use of the polymerase chain reaction (PCR). | 2015-04-16 |
20150104849 | METHODS OF PURIFYING RECOMBINANT ADAMTS13 AND OTHER PROTEINS AND COMPOSITIONS THEREOF - Provided herein are methods for purifying recombinant A Disintegrin-like and Metallopeptidase with Thrombospondin Type 1 Motif 13 (ADAMTS13) protein from a sample. The method comprises enriching for ADAMTS13 protein by chromatographically contacting the sample with hydroxyapatite under conditions that allow ADAMTS13 protein to appear in the eluate or supernatant from the hydroxylapatite. The methods may further comprise tandem chromatography with a mixed mode cation exchange/hydrophobic interaction resin that binds ADAMTS13 protein. Additional optional steps involve ultrafiltration/diafiltration, anion exchange chromatography, cation exchange chromatography, and viral inactivation. Also provided herein are methods for inactivating virus contaminants in protein samples, where the protein is immobilized on a support. Also provided herein are compositions of ADAMTS13 prepared according to said methods. | 2015-04-16 |
20150104850 | PROTEIN MANIPULATION - A method of improving the folding of an enzyme comprising a thiamine pyrophosphate (TPP) binding domain, the method comprising: providing a nucleic acid encoding the enzyme comprising a TPP binding domain, in which one or more of the TPP binding domains in the enzyme monomer are replaced with a TPP binding domain from a thermostable TPP-binding protein, and expressing the nucleic acid under conditions that allow expression and folding of the enzyme. The enzyme may be pyruvate decarboxylase. | 2015-04-16 |
20150104851 | METHOD FOR THE BIOCATALYTIC CYCLIZATION OF TERPENES AND CYCLASE MUTANTS EMPLOYABLE THEREIN - The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene. | 2015-04-16 |
20150104852 | CONTROLLED ACTIVATION OF THE REUTERIN-PRODUCTION MACHINERY OF LACTOBACILLUS REUTERI - Methods for the control led activation of the reuterin-production machinery of | 2015-04-16 |
20150104853 | COMPOSITIONS AND METHODS OF PGL FOR THE INCREASED PRODUCTION OF ISOPRENE - Provided herein are improved compositions and methods for the increased production of isoprene. Also provided herein are improved compositions and methods for the increased production of heterologous polypeptides capable of biological activity. | 2015-04-16 |
20150104854 | METABOLICALLY ENGINEERED METHANOTROPHIC, PHOTOTROPHIC MICROORGANISMS - This disclosure relates to the engineering of phototrophic microorganisms for conversion of alkanes into higher-value products. Recombinant phototrophic organisms such as cyanobacteria can be engineered, optionally in a modular format, to express enzymes involved in converting methane to methanol, methanol to formaldehyde, formaldehyde to central metabolic pathway intermediates, and such intermediates to n-butanol. | 2015-04-16 |
20150104855 | Enhanced combination method for phytoremediation of petroleum contaminated soil by Impatiens balsamina L. associated with the indigenous microorganisms - A plant-microorganism combined method for phhytoremediation of organic contaminated soil; i.e., an ornamental plant ( | 2015-04-16 |
20150104856 | Detergent Compositions - A detergent composition comprising a polypeptide having protease activity is disclosed. The composition may be used in laundry or hard surface cleaning such as automated dish wash, and it has improved performance compared with a commercial protease. | 2015-04-16 |
20150104857 | PHOTOBIOREACTOR SYSTEM FOR AIR PURIFICATION - The present invention relates to air purification. The present invention provides a system for reducing carbon dioxide concentration in air in locations with sub-tropical to temperate climates and method of reducing carbon dioxide concentration using the system. | 2015-04-16 |
20150104858 | NUCLEIC ACID SAMPLE PREPARATION - The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples. | 2015-04-16 |
20150104859 | Rapid Thermal Cycling for PCR Reactions using Enclosed Reaction Vessels and Linear Motion - A system for fast, accurate and inexpensive thermal cycling is disclosed including a set of thermally conductive plates that are maintained in a fixed spatial relationship to each other, and separated from each other by a thermal insulating space. A hole having a size approximately equal to a size of a desired test sample is formed through the set of thermally conductive plates. The test sample is placed in the hole and moved back and forth between the different temperature plates, to the desired temperature locations for desired time periods, in a pattern that is determined by the user, and repeated as many times as needed for the specific process. | 2015-04-16 |
20150104860 | Smartphone Biosensor - A mobile computing device that includes an image sensor may be used to detect the result of a biomolecular assay. The biomolecular assay may be performed in an optical assay medium that provides an optical output in response to light from a light source, with the optical output indicating result. A wavelength-dispersive element may be used to disperse the optical output into spatially-separated wavelength components. The mobile computing device may be positioned relative to the wavelength-dispersive element such that different wavelength components are received at different locations on the image sensor. With the mobile computing device positioned in this way, the image sensor may be used to obtain one or more images that include the separated wavelength components of the optical output. A wavelength spectrum of the optical output may be determined from the one or more images, and the result may be determined from the wavelength spectrum. | 2015-04-16 |
20150104861 | SYSTEM AND METHOD FOR DETECTION OF A CONTAMINATED BEVERAGE - An apparatus may be configured to test a beverage, the apparatus may include but is not limited to, a beverage container that may be configured to hold a beverage, wherein the beverage container may include a material. An indicator may be chemically bonded to at least a portion of the material of the beverage container, wherein at least the portion of the material of the beverage container may include the indicator, wherein the indicator may be associated with at least part of a brand profile to identify a beverage brand's beverage, wherein the indicator may visibly react when the indicator is contacted with the beverage to show whether the beverage may be identified as the beverage brand's beverage, and wherein the visible reaction may be shown on at least the portion of the material of the beverage container via the indicator chemically bonded to at least the portion of the material of the beverage container. | 2015-04-16 |
20150104862 | METHODS FOR GASIFICATION OF CARBONACEOUS MATERIALS - The present disclosure is generally directed to process of gasification of carbonaceous materials to produce synthesis gas or syngas. The present disclosure provides improved methods of gasification comprising: adding one or more carbonaceous materials, adding a molecular oxygen-containing gas, adding carbon dioxide gas and optionally adding water into said gasifier. This disclosure is also directed to process of production of one or more alcohols from said syngas via fermentation or digestion in the presence of at least one microorganism. | 2015-04-16 |
20150104863 | VECTORS AND SEQUENCES FOR THE TREATMENT OF DISEASES - The present invention provides new sequences, gene constructions, vectors and pharmaceutical compositions for the treatment of diseases and specially, for the treatment of mucopolysaccharidoses. | 2015-04-16 |
20150104864 | METHOD FOR GENERATING CANCER STEM CELLS FROM IMMORTALIZED CELL LINES - A method is described for generating a novel cancer stem cell line that possesses characteristics associated with stem cells, by co-culturing a human immortalized cell line and bone marrow-derived mesenchymal stem cells, and the novel cancer stem cell line established thereby. This method is able to readily generate cancer stem cells that are low in the level of structural chromosomal aberrations and are excellent in oncogenicity, and is effectively applicable to the development of anti-cancer drugs and personalized drugs. | 2015-04-16 |
20150104865 | ENGINEERED HETERODIMERIC PROTEIN DOMAINS - The present invention provides an engineered multidomain protein including at least two nonidentical engineered domains, each of which contains a protein-protein interaction interface containing amino acid sequence segments derived from two or more existing homologous parent domains, thereby conferring on the engineered domains assembly specificities distinct from assembly specificities of the parent domains. In particular, the engineered domains form heterodimers with one another preferentially over forming homodimers. Methods of designing and using the engineered proteins are also included. | 2015-04-16 |
20150104866 | IP-10 ANTIBODIES AND THEIR USES - The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases. | 2015-04-16 |
20150104867 | ANIMAL PROTEIN-FREE MEDIA FOR CULTIVATION OF CELLS - The present invention relates to animal protein-free cell culture media comprising polyamines and a plant- and/or yeast-derived hydrolysate. The invention also relates to animal protein-free culturing processes, wherein cells can be cultivated, propagated and passaged without adding supplementary animal proteins in the culture medium. These processes are useful in cultivating cells, such as recombinant cells or cells infected with a virus, and for producing biological products by cell culture processes. | 2015-04-16 |
20150104868 | Methods of Maintaining and Improving Biological Cell Function and Activity - The present invention relates to methods of using meso-1,2,3,4-tetrahydroxybutane for the maintenance and/or improvement of biological cell function and activity, and for the prevention of improper cell functioning or cell death, in vitro, ex vivo, and in vivo over time and/or during exposure to stress. Meso-1,2,3,4-tetrahydroxybutane can be used to promote cell survival and as a cell protection agent, to increase cell viability, and to improve conversion of progenitor or stem cells to mature cells, whether in vitro, in vivo, ex-vivo, or transplanted. | 2015-04-16 |
20150104869 | Small Activating RNA Molecules and Methods of Use - The present invention provides compositions, pharmaceutical preparations, kits and methods for increasing expression of a gene product in a cell by contacting the cell with a small activating RNA (saRNA) molecule comprising a ribonucleic strand that is complementary to a non-coding nucleic acid sequence of the gene. | 2015-04-16 |
20150104870 | NEURONAL DIFFERENTIATION PROMOTER - The present invention provides an agent for promoting neuronal differentiation of neural stem cells, which contains a p38 inhibitor. In addition, the present invention provides a method of promoting neuronal differentiation of neural stem cells, which includes cultivating neural stem cells in the presence of a p38 inhibitor. Neural stem cells are gliogenic or neurogenic. The p38 inhibitor is a nucleic acid which hybridizes to DNA or mRNA encoding p38 under physiological conditions, thereby inhibiting the transcription and/or translation thereof, an expression vector of the nucleic acid, a low molecular p38 inhibitor and the like. | 2015-04-16 |
20150104871 | MEDIUM COMPRISING TRANSFORMING GROWTH FACTOR BETA 1 AND BASIC FIBROBLAST GROWTH FACTOR - The present invention is of methods of establishing and propagating human embryonic stem cell lines using feeder cells-free, xeno-free culture systems and stem cells which are capable of being maintained in an undifferentiated, pluripotent and proliferative state in culture which is free of xeno contaminants and feeder cells. | 2015-04-16 |
20150104872 | CELL-SUPPORT MATRIX HAVING NARROWLY DEFINED UNIFORMLY VERTICALLY AND NON-RANDOMLY ORGANIZED POROSITY AND PORE DENSITY AND A METHOD FOR PREPARATION THEREOF - A cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof. The matrix suitable for preparation of cellular or acellular implants for growth and de novo formation of an articular hyaline-like cartilage. A gel-matrix composite system comprising collagen-based matrix having a narrowly defined porosity capable of inducing hyaline-like cartilage production from chondrocytes in vivo and in vitro. | 2015-04-16 |
20150104873 | Genome Surgery with Paired, Permeant Endonuclease Construct - A chemical tool and its use in genome surgery includes P2E2 constructs of in, order, a cell penetration component, a DNA binding component and a restriction endonuclease. The method for performing genome surgery includes:
| 2015-04-16 |
20150104874 | AKT Ligands and Polynucleotides Encoding AKT Ligands - The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate AKT activity. The ligands, homopolyligands, and heteropolyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands, homopolyligands, and heteropolyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands, homopolyligands, and heteropolyligands. | 2015-04-16 |
20150104875 | ALGAL ELONGASE 6 - Provided herein are exemplary isolated nucleotide sequences encoding polypeptides having elongase activity, which utilize fatty acids as substrates. | 2015-04-16 |
20150104876 | RELEASE REAGENT FOR VITAMIN D COMPOUNDS - The present invention concerns a reagent composition for releasing vitamin D compounds bound to vitamin D-binding protein, a method for the detection of a 25-hydroxyvitamin D compound in which the 25-hydroxyvitamin D compound is released from vitamin D-binding protein using this reagent and the mixture obtained in this manner is analyzed, the use of the reagent to release vitamin D compounds as well as a kit for detecting 25-hydroxyvitamin D which contains the reagent for releasing vitamin D compounds in addition to the usual immunological reagents. | 2015-04-16 |
20150104877 | USE OF DISULFIDE BONDS TO FORM A REVERSIBLE AND REUSABLE COATING FOR NANOFLUIDIC DEVICES - A reusable coating for a nanopore structure is disclosed herein. A nanopore structure includes a substrate comprising a nanochannel and a monolayer of a chemical compound disposed onto at least a portion of a surface of the nanochannel. The chemical compound forms a reversible bond with at least one analyte binding compound introduced into the nanochannel. Methods for making and using the reusable coating are also disclosed. | 2015-04-16 |
20150104878 | METHODS OF TRIGGERING ACTIVATION OF ENCAPSULATED SIGNAL-GENERATING SUBSTANCES AND APPARATUS UTILISING ACTIVATED SIGNAL-GENERATING SUBSTANCES - Methods are disclosed for performing a bioassay, comprising activating capsules containing a signal precursor that is hydrolysable from a latent form in which substantially no signal is generated to a form in which it is able to generate a detectable signal, said activating comprising treating said capsules with heat and with an acid or a base catalysing solution, the combination of said heat and the pH of the catalysing solution being such as to hydrolyse said precursor to the form in which it is able to generate a detectable signal. | 2015-04-16 |
20150104879 | COMPOSITION FOR DIAGNOSING LIVER CANCER AND METHODS OF DIAGNOSING LIVER CANCER AND OBTAINING INFORMATION FOR DIAGNOSING LIVER CANCER - Provided is method of diagnosing liver cancer in a subject, the method comprising contacting a sample from a subject with a substance that specifically binds to transmembrane emp24 domain trafficking protein 2 (TMED2), cluster of differentiation 43 (CD43), or any combination thereof on the surface of a microvesicle; and measuring the level of the substance bound to microvesicles in the sample; and related methods and compositions. | 2015-04-16 |
20150104880 | ANALYTE DETECTION METHOD, FLUORESCENCE DETECTION METHOD, AND FLUORESCENCE DETECTION APPARATUS USING SAME - Disclosed is an analyte detection method for detecting an analyte contained in a biological sample, constituted by irradiating a light of a first peak wavelength on a complex containing an analyte and fluorescent substance which gives off light of a second peak wavelength of 450 nm or higher but not exceeding 900 nm when irradiated with light of the first wavelength of 190 nm or higher but not exceeding 350 nm, detecting the light of the second peak wavelength given off by the fluorescent substance when irradiated by light of the first peak wavelength, by a photodetector, wherein the photodetector has a quantum efficiency in the second peak wavelength that is two or more times the quantum efficiency in the first peak wavelength. | 2015-04-16 |
20150104881 | SGLT2 AS BIOMARKER FOR DIAGNOSING CHRONIC KIDNEY DISEASE AND MONITORING THE DISEASE STATUS AFTER TREATMENT - The present invention relates to a method for diagnosis of a chronic kidney disease in a subject by detecting the expression level of a sodium-glucose linked transporter 2 (SGLT2) protein in urine samples. A method for monitoring progression of a chronic kidney disease in a patient is also provided. | 2015-04-16 |
20150104882 | FABRICATION METHOD FOR HIGH-DENSITY MRAM USING THIN HARD MASK - Embodiments of the invention are described that use a thin metallic hard mask, which can be a bi-layer film, to increase the incident IBE angle for MTJ sidewall cleaning without losing the process margin for the subsequent interconnection process. The patterned metallic hard mask pads also serve as the top electrode for the MTJ cells. Using a thin metallic hard mask is possible when the hard mask material acts as a CMP stopper without substantial loss of thickness. In the first embodiment, the single layer hard mask is preferably ruthenium. In the second embodiment, the lower layer of the bi-layer hard mask is preferably ruthenium. The wafer is preferably rotated during the IBE process for uniform etching. A capping layer under the hard mask is preferably used as the etch stopper during hard mask etch process in order not to damage or etch through the upper magnetic layer. | 2015-04-16 |
20150104883 | SEMICONDUCTOR DEVICES AND METHODS FOR FABRICATING THE SAME - A method of fabricating a semiconductor device includes providing a wafer in a chamber of a point-cusp magnetron physical vapor deposition (PCM-PVD) apparatus, the chamber including a metal target. The method further includes providing an inert gas and a reactive gas in the chamber and forming an amorphous conductive layer on the wafer by reacting the reactive gas with a metal atom separated from the metal target by the inert gas. | 2015-04-16 |
20150104884 | SEMICONDUCTOR MEMORY DEVICE AND MANUFACTURING METHOD THEREOF - A method for manufacturing a semiconductor memory device includes forming a magnetic tunnel junction layer on a lower electrode, forming a spacer having an annular shape on the magnetic tunnel junction layer, forming upper electrodes on both sidewall surfaces of the annular shaped spacer, removing the spacer, and etching the magnetic tunnel junction layer by using the upper electrodes as an etch mask. | 2015-04-16 |
20150104885 | MOVEABLE CURRENT SENSOR FOR INCREASING ION BEAM UTILIZATION DURING ION IMPLANTATION - An ion implant apparatus and moveable ion beam current sensor are described. Various examples provide moving the ion beam current sensor during an ion implant process such that a distance between the ion beam current sensor and a substrate is maintained during scanning of the ion beam toward the substrate. The ion beam current sensor is disposed on a moveable support configured to move the ion beam current sensor in a first direction corresponding to the scanning of the ion beam while the substrate is moved in a second direction. | 2015-04-16 |
20150104886 | SEMICONDUCTOR DEVICE ARRANGEMENT, A METHOD OF ANALYSING A PERFORMANCE OF A FUNCTIONAL CIRCUIT ON A SEMICONDUCTOR DEVICE AND A DEVICE ANALYSIS SYSTEM - A semiconductor device arrangement comprising a functional circuit comprising a plurality of timing components and a reference module comprising a plurality of reference components is described. Each reference component comprises a reference timing component corresponding to a timing component of the plurality of timing components and a controllable timing component. The controllable timing component is arranged to provide a delay in dependence on an applied light stimulus. A method of analysing a performance of a functional circuit on a semiconductor device is also described. A device analysis system for analysing a functional circuit comprising a plurality of timing components is also described. | 2015-04-16 |
20150104887 | METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE - A method of manufacturing a semiconductor device includes generating a mask layout of patterns in which the distance between adjacent ones of the patterns is equal to or less than a resolution of a lithography process, the patterns are apportioned among a plurality of masks such that in each of the masks the space between adjacent ones of the patterns is greater than the resolution, and a dual pattern is added to one of the masks. A semiconductor pattern is formed on a substrate using the mask(s) and the mask to which the dual pattern has been added. Patterns having a pitch equal to or less than the resolution may be formed on the semiconductor device. | 2015-04-16 |
20150104888 | SYSTEM FOR DETERMINING PRESENCE OF ABNORMALITY OF HEATER FOR SEMICONDUCTOR THIN FILM DEPOSITION APPARATUS - The present invention relates, in general, to an apparatus for determining the presence of abnormality of a heater for a semiconductor thin film deposition apparatus, such as an aluminum or ceramic heater and, more particularly, to a technique for monitoring a phenomenon occurring in an apparatus during a semiconductor thin film deposition process and a phenomenon occurring in a heater, thereby determining the presence of abnormality of the heater. The present invention also relates to a technique for measuring, in real time, a thickness of a thin film deposited by driving of a heater during a thin film deposition process in a chamber, thereby determining the presence of abnormality of a wafer and the presence of abnormality of the heater, based on the measurement result. | 2015-04-16 |
20150104889 | SEMICONDUCTOR DEVICE, MANUFACTURING METHOD OF SEMICONDUCTOR DEVICE, SEMICONDUCTOR MANUFACTURING AND INSPECTING APPARATUS, AND INSPECTING APPARATUS - A semiconductor device having Cu wiring including a basic crystal structure which can reduce surface voids, and an inspecting technique for the semiconductor device. In the semiconductor device, surface voids can be reduced down to 1/10 or less of a current practical level by specifying a barrier layer and a seed layer and setting a proportion (frequency) of occupation of a coincidence site lattice (CSL) boundary having a grain boundary Sigma value 27 or less to all crystal grain boundaries of a Cu wiring to 60% or higher. Alternatively, a similar effect of surface void reduction can be obtained by specifying a barrier layer and a seed layer and setting a proportion (frequency) of occupation of a coincidence site lattice (CSL) boundary having a grain boundary Sigma value 3 to all crystal grain boundaries of a Cu wiring to 40% or higher. | 2015-04-16 |
20150104890 | SEMICONDUCTOR LIGHT EMITTING DEVICE AND FABRICATION METHOD THEREOF - A semiconductor light emitting device includes a substrate having first and second electrode patterns on at least one surface thereof, a light emitting structure on a surface of the substrate, a first electrode structure, a second electrode structure, an insulating layer, a first connection portion connecting the first electrode structure and the first electrode pattern, and a second connection portion connecting the second electrode structure extending outwardly from the light emitting structure and the second electrode pattern. | 2015-04-16 |
20150104891 | METHOD FOR PRODUCING A SUBSTRATE FOR ORGANIC ELECTRONIC DEVICES - Provided are methods of manufacturing a substrate for an OED and an OED. According to the methods of manufacturing a substrate for forming an OED such as an OLED and an OED, a substrate for forming a device having excellent light extraction efficiency and improved reliability by preventing penetration of moisture or air into the device, or device using the same may be provided. | 2015-04-16 |
20150104892 | MICROLENS FOR ORGANIC EL ELEMENT, ORGANIC EL ELEMENT USING THE SAME, AND MANUFACTURING METHODS THEREOF - A microlens for an organic EL element, which is used by being disposed on a light-emitting surface of the organic EL element, said microlens comprising a cured resin layer having concavities and convexities formed on a surface thereof, wherein when a Fourier-transformed image is obtained by performing two-dimensional fast Fourier transform processing on a concavity and convexity analysis image obtained by analyzing a shape of the concavities and convexities by use of an atomic force microscope, the Fourier-transformed image shows a circular or annular pattern substantially centered at an origin at which an absolute value of wavenumber is 0 μm | 2015-04-16 |
20150104893 | METHOD OF PRODUCING PHOTO-ALIGNMENT LAYER OF LIQUID CRYSTAL DISPLAY - A method of manufacturing a photo-alignment layer, includes: disposing a polymer material on a substrate; pre-baking the polymer material disposed on the substrate; irradiating a light to the pre-baked polymer material, to photo-align the pre-baked polymer material; and thermal-treating the irradiated pre-baked polymer material, to harden the irradiated pre-baked polymer material. The thermal-treating includes a first thermal-treatment, and a second thermal-treatment at a higher temperature than the first thermal-treatment. | 2015-04-16 |
20150104894 | LIGHT-EMITTING PANEL, MANUFACTURING METHOD OF LIGHT-EMITTING PANEL, AND FILM FORMING SYSTEM - A light-emitting panel includes: a substrate and a light-emitting functional multilayer formed on the substrate, wherein the light-emitting functional multilayer including a first functional layer and a second functional layer, a thickness of part of the first functional layer positioned in a first light-emitting region is smaller than a thickness of part of the first functional layer positioned in a second light-emitting region, a thickness of part of the second functional layer positioned in the first light-emitting region is greater than a thickness of part of the second functional layer positioned in the second light-emitting region, and when the light-emitting functional multilayer is viewed in a layering direction, the first light-emitting region and the second light-emitting region are adjacent or distant from each other in a direction perpendicular to the layering direction, and each include a plurality of pixels that are each composed of a plurality of adjacent sub-pixels. | 2015-04-16 |
20150104895 | METHOD OF FABRICATING MEMS DEVICES HAVING A PLURALITY OF CAVITIES - A method for forming an integrated circuit having Micro-electromechanical Systems (MEMS) includes forming at least two recesses into a first layer, forming at least two recesses into a second layer, the at least two recesses of the second layer being complementary to the recesses of the first layer. An intermediate layer is bonded onto the second layer, the intermediate layer includes through-holes corresponding to the recesses of the second layer. The first layer is bonded to the intermediate layer such that cavities are formed, the cavities to act as operating environments for MEMS devices. The two cavities have different pressures. | 2015-04-16 |