| 15th week of 2009 patent applcation highlights part 37 |
| Patent application number | Title | Published |
|---|
| 20090093518 | Piperidinyl-substituted isoquinolone derivatives - The invention relates to 6-piperidinyl-substituted isoquinolone derivatives of the formula (I) | 2009-04-09 |
| 20090093519 | Methods and Compositions to Inhibit Edema Factor and Adenylyl Cyclase - Small molecules and their derivatives are described for the treatment and/or prevention of intestinal fluid loss. Also disclosed are methods of using said molecules and their derivatives to treat and/or prevent conditions associated with increased levels of 3′,5′-adenosine monophosphate. Specific compositions of the invention are also novel. | 2009-04-09 |
| 20090093520 | PLASMA CARBOXYPEPTIDASE B INHIBITORS - Compounds of the following formula (I), for example: | 2009-04-09 |
| 20090093521 | 2, 5-Bis-Diamine [1,4] Benzoquinone-Derivatives - Synthesis of 2,5-bis-diamine-[1,4]benzoquinonic derivatives having the general formula (I), products and intermediates of said synthesis; the synthesis involves the use of p-benzoquinones having the general formula (IX) and diamines having the general formula (XI). | 2009-04-09 |
| 20090093522 | Freeze-dried pantoprazole preparation and pantoprazole injection - Lyophilized pantoprazole preparations which are obtainable by freeze-drying of an aqueous solution of pantoprazole, ethylenediamine tetraacetic acid and/or a suitable salt thereof, and sodium hydroxide and/or sodium carbonate are disclosed. The preparations have advantageous properties when reconstituted for injection. | 2009-04-09 |
| 20090093523 | Tetrazole-substituted aryl amide derivatives and uses thereof - Compounds of the formula: | 2009-04-09 |
| 20090093524 | COMPOUNDS AND METHODS FOR MODULATING FXR - Compounds of formula (I) wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases. | 2009-04-09 |
| 20090093525 | Cyclopropyl aryl amide derivatives and uses thereof - Compounds of the formula: | 2009-04-09 |
| 20090093526 | INHIBITION OF P38 KINASE USING SYMMETRICAL AND UNSYMMETRICAL DIPHENYL UREAS - This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases and proteolytic enzyme mediated diseases, and pharmaceutical compositions for use in such therapy. | 2009-04-09 |
| 20090093527 | Azacyclopentane Derivatives as Inhibitors of Stearoyl-Coenzyme a Delta-9 Desaturase - Azacyclopentane derivatives of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; liver steatosis; and non-alcoholic steatohepatitis. | 2009-04-09 |
| 20090093528 | METHODS FOR PROMOTING COMPOSITE TISSUE REGENERATION AND USES THEREOF - The present invention provides a use and method for GM284 to promote the regeneration of a bodily structure, comprised of a composite tissue in a subject. Additionally, the present invention provides a use and method for GM284 to promote composite tissue regeneration in a subject. The present invention further provides a use and method for GM284 to promote the regeneration of cells of a composite tissue in a subject. Finally, the present invention provides a use and method for GM284 to treat an injury to a composite tissue in a subject in need of such treatment. | 2009-04-09 |
| 20090093529 | REMEDY FOR OVERACTIVE BLADDER COMPRISING ACETIC ACID ANILIDE DERIVATIVE AS THE ACTIVE INGREDIENT - (R)-2-(2-aminothiazol-4-yl)-4′-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetic acid anilide or its salt shows a potent bladder relaxation effect in “isolated rat bladder smooth muscle relaxation test”, dose-dependently lowers the contraction frequency of rhythmic bladder contractions in “rat rhythmic bladder contraction measurement test” and, moreover, prolongs the urination intervals in “urination functions measurement test on cyclophosphamide-induced overactive bladder model rat”. Owing to these effects, the above compound is useful as a remedy for overactive bladder. | 2009-04-09 |
| 20090093530 | (2R)-2-[4-Sulfonyl) Aminophenyl] Propanamides and Pharmaceutical Compositions Containing Them - The present invention relates to novel (2R)-2-phenylpropanamides bearing a 4-sulfonylamino substituent on the 4 position of the phenyl group and to pharmaceutical compositions containing them, which are used as inhibitors of the chemotaxis of polymorphonucleate and mononucleate cells, and which are useful in the treatment of various ELR+CXC chemokine-mediated disorders. In particular, the compounds of the invention are useful in the treatment and control of specific CXCR2 dependent pathologies such as BOS, COPD, angiogenesis and melanoma. | 2009-04-09 |
| 20090093531 | Co-Solvent Compositions and Methods for Improved Delivery of Dantrolene Therapeutic Agents - The present invention provides for methods of using tert-butyl alcohol (TBA) co-solvent systems in the formulation and production of a pharmaceutical agent with low solubility. The present invention also provides for pharmaceutical compositions made using the novel co-solvent system. In one embodiment, the invention provides for a method of making dantrolene sodium (DS) formulation for intravenous use (DS-IV). This instantaneous reconstitution of the DS-IV product constitutes a significant improvement in the pharmacotherapy of patients undergoing malignant hyperthermia during surgery. | 2009-04-09 |
| 20090093532 | POLYMORPHS AND AMORPHOUS FORMS OF 5-AMINO-1-[2,6-DICHLORO-4-(TRIFLUOROMETHYL)PHENYL]-4-[(TRIFLUOROMETHYL)SU- LFINYL]-1H-PYRAZOLE-3-CARBONITRILE - The present invention relates to novel crystalline polymorphs, solvate pseudomorphs and amorphous form of 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile (fipronil). The present invention also provides methods for preparing the novel polymorphs, pseudomorphs and amorphous form, as well as insecticidal or pesticidal compositions comprising same, and methods of use thereof as pesticidal agents. | 2009-04-09 |
| 20090093533 | COMPOUNDS AND METHODS FOR INHIBITING HEPATITIS C VIRAL REPLICATION - Macrocyclic compounds having the structures described herein are useful for inhibiting replication of the hepatitis C virus (HCV). In preferred embodiments, the compounds are active against both the NS3 protease and the NS3 helicase of HCV. | 2009-04-09 |
| 20090093535 | Method and composition for treating heart failure - A method and composition for treating, preventing or ameliorating heart failure, cardiac hypertrophy, and/or myocardial dysfunction includes administering a therapeutically effective amount of a HDAC inhibitor, such as phenylbutyrate, in combination with an ACE inhibitor, such as captopril. | 2009-04-09 |
| 20090093536 | PHARMACEUTICAL COMPOSITION COMPRISING THIACREMONONE FOR PREVENTING OR TREATING CANCER - The present invention relates to an anti-cancer composition, which comprises a sulfur-containing compound thiacremonone as an active ingredient. The active ingredient induces the death of cancer cells by apoptosis through the action of specific inhibition of the activity of NF-κB. The composition can be effectively used in the treatment or prevention of cancer. | 2009-04-09 |
| 20090093537 | Extracts rich in proanthocyanidins and relating process of preparation - The present invention relates to extracts containing high amounts of proanthocyanidins and the relating process of preparation involving the use as starting reactants of crushed fruits, plants or already prepurified extracts rich in proanthocyanidins. | 2009-04-09 |
| 20090093538 | Method for treating cancer - The invention relates to a method of treating cancer in a subject, comprising administering to the subject an anti-cancer therapy and a compound that increases the oxidative stress of the cancer cells and activates p38. | 2009-04-09 |
| 20090093539 | ANTI-ANGIOGENIC COMPOSITIONS AND METHODS OF USE THEREOF - The present invention provides methods of reducing angiogenesis in an individual. The methods generally involve administering to the individual an effective amount of a tanshinone compound. The methods are useful to treat conditions associated with or resulting from angiogenesis, particularly pathological angiogenesis. The invention further provides methods of treating a condition associated with or resulting from angiogenesis. | 2009-04-09 |
| 20090093540 | ANTI-TUMOR COMPOSITION - The present invention provides compositions having, as active ingredients, a stilbene derivative and a platinum coordination compound which is highly efficacious and highly safe for treating tumors, particularly for the treatment of solid or malignant tumors and thus methods of cancer and tumor treatment using the composition are also provided. | 2009-04-09 |
| 20090093541 | MELANIN ELIMINATOR PREPARATION - A melanin eliminator preparation comprising a metal chelate compound represented by the following formula (I), | 2009-04-09 |
| 20090093542 | Copper antagonist compositions - Pharmaceutical compositions having a pharmaceutically acceptable copper antagonist(s) or a pharmaceutically acceptable salts or prodrugs thereof, including copper (II) antagonists, and a pharmaceutically acceptable antihypertensive agent or a pharmaceutically acceptable salt or prodrug thereof, articles and kits and delivery devices containing compositions, tablets and capsules and formulations containing such compositions, and methods of use for treatment of subjects, including humans, who have or are at risk for various diseases, disorders, and conditions. | 2009-04-09 |
| 20090093543 | OPTIMIZED STRAINS OF YARROWIA LIPOLYTICA FOR HIGH EICOSAPENTAENOIC ACID PRODUCTION - Engineered strains of the oleaginous yeast | 2009-04-09 |
| 20090093544 | INSECTICIDAL COMPOSITIONS HAVING IMPROVED EFFECT - The present invention relates to the increase of the action of crop protection agents containing certain phthalic acid diamides by the addition of ammonium salts and/or phosphonium salts or by the addition of ammonium or phosphonium salts and penetration promoters, the corresponding agents, processes for their preparation and their use in crop protection. | 2009-04-09 |
| 20090093545 | PHENOXYALKYCARBOXYLIC ACID DERIVATIVES IN THE TREATMENT OF IRRITABLE BOWEL SYNDROME OR ULCERATIVE COLITIS - A method of treating irritable bowel syndrome, ulcerative colitis, and other inflammatory conditions, comprising: administering to a patient in need thereof an effective amount of a compound selected from compound 1, its metabolite 2 and pharmaceutically acceptable salts or prodrugs thereof: | 2009-04-09 |
| 20090093546 | Method and Pharmaceutical Compositions for Treatment of Anti-Estrogen Resistant Breast Cancer Using RXR Modulators - Methods and compositions for the treatment of anti-estrogen resistant breast cancer using retinoid compounds that are modulators of Retinoid X Receptors are provide. | 2009-04-09 |
| 20090093547 | Compositions and Methods for Treating Premature Ejaculation - Compositions and methods for the treatment of premature ejaculation have been developed. It has been discovered that premature ejaculation can be treated by administering a local anesthetic to the glans penis. The local anesthetic may be formulated as an emulsion, lotion, paste, gel, cream, ointment, shea butter, suspension, solution, balm, salve, foam, or in the form of a pump spray to achieve local anesthesia of the dorsal neurons of the penis. | 2009-04-09 |
| 20090093548 | COLCHINE COMPOSITIONS AND METHODS - Stable ultrapure colchicine compositions comprising ultrapure colchicine and a pharmaceutically acceptable excipient are described. The compositions can be tablets. Methods for preparing such compositions and methods of use are also disclosed. Methods of treating gout flares with colchicine compositions are also disclosed. | 2009-04-09 |
| 20090093549 | Aqueous Pharmaceutical Compositions Of 2,6-Diisopropylphenol (Propofol) And Their Uses - The present invention provides aqueous pharmaceutical compositions containing a lipophilic therapeutic agent. In particular, the invention provides aqueous pharmaceutical compositions containing the compound 2,6-diisopropylphenol (propofol). Preferred compositions of the invention contain propofol in the presence of at least one block copolymer (for example, P188 or another poloxamer) and a polyethylene glycol (PEG). Compositions of the invention are preferably sterile or are readily sterilized (e.g., by autoclaving) and are suitable for parenteral administration to any animal, including humans. The compositions are also chemically and physically stable over a wide range of environmental conditions and for extended periods of time. | 2009-04-09 |
| 20090093550 | Biocompatible foams, systems, and methods - Biocompatible foams having excellent physical and chemical properties are described. The biocompatible foams can be formed in situ or applied as a pre-formed foam for the treatment of tissue. The invention provides biocompatible degradable foams formed with a poly-α(1→4)glucopyranose macromer. The invention also provides biostable foams formed with a poly(alkylene oxide) macromer. | 2009-04-09 |
| 20090093551 | REMOTELY TRIGGERED RELEASE FROM HEATABLE SURFACES - The present invention provides particle conjugates for drug delivery. Such conjugates comprise one or more heatable surfaces, one or more thermally-responsive linkers, and one or more agents to be delivered. In some embodiments, conjugates and populations of conjugates can be used to treat and/or diagnose a disease, disorder, and/or condition. The present invention provides methods for producing and/or using thermally-responsive conjugates. | 2009-04-09 |
| 20090093552 | Addition of lecithin as an antistatic agent for the crystallization processing of organic molecules - The present invention relates to the addition of lecithin during the crystallization of organic molecules in organic solvents as an antistatic agent to reduce or eliminate static buildup, thus reducing the potential for explosion and equipment damage during chemical processing. | 2009-04-09 |
| 20090093553 | METHOD FOR THE PRODUCTION OF SUSPENSIONS OF NANOPARTICULATE SOLIDS - The invention relates to a process for preparing suspensions of nanoparticulate solids, wherein the solids present in the suspension are present in the form of nanoparticulate primary particles or very small aggregates. | 2009-04-09 |
| 20090093554 | HIGHLY DISPERSIBLE CARBON NANOSPHERES IN AN ORGANIC SOLVENT AND METHODS FOR MAKING SAME - The particle sizes of agglomerates of carbon nanospheres are reduced by dispersing the carbon nanospheres in an organic solvent. The carbon nanospheres are multi-walled, hollow, graphitic structures with an average diameter in a range from about 10 nm to about 200 nm, more preferably about 20 nm to about 100 nm. Spectral data shows that prior to being dispersed, the carbon nanospheres are agglomerated into clusters that range in size from 500 nm to 5 microns. The clusters of nanospheres are reduced in size by dispersing the carbon nanospheres in an organic solvent containing at least one heteroatom (e.g., NMP) using ultrasonication. The combination of organic solvent and ultrasonication breaks up and disperses agglomerates of carbon nanospheres. | 2009-04-09 |
| 20090093555 | METHODS AND APPARATUS FOR PRODUCING SYNGAS - This invention features methods and apparatus for producing syngas from any carbon-containing feed material. In some embodiments, a substoichiometric amount of oxygen is used to enhance the formation of syngas. In various embodiments, a catalyst is derived from the ash content of the feed material, and this catalyst is used to enhance syngas formation. The syngas can be converted to alcohols, such as ethanol, or to other products. | 2009-04-09 |
| 20090093556 | Electronically and ionically conductive porous material and method for manufacture of resin wafers therefrom - An electrically and ionically conductive porous material including a thermoplastic binder and one or more of anion exchange moieties or cation exchange moieties or mixtures thereof and/or one or more of a protein capture resin and an electrically conductive material. The thermoplastic binder immobilizes the moieties with respect to each other but does not substantially coat the moieties and forms the electrically conductive porous material. A wafer of the material and a method of making the material and wafer are disclosed. | 2009-04-09 |
| 20090093557 | METHOD FOR OPTIMIZATION OF RPET DECONTAMINATION - A process for decontaminating recycled polyethylene terephthalate (RPET) is disclosed, the process involves determining an accumulated thermal history (ATH) of the RPET, including the thermal history of any process steps performed by a subsequent possessor of the RPET, to result in an optimized decontamination process for decontaminating the RPET to a desired level. | 2009-04-09 |
| 20090093558 | MOBILE EXPANDED POLYMER PROCESSING SYSTEMS AND METHODS - A mobile polymer system. The system includes a mobile platform and a heat generating device mounted to the mobile platform. The system also includes a polymer expansion unit mounted to the mobile platform, wherein the polymer expansion unit is adapted to expand a polymer, using heat generated by the heat generating device, at a location of the mobile polymer expansion system to create an expanded polymer that can be used to create an expanded polymeric product that is comprised of the expanded polymer. | 2009-04-09 |
| 20090093559 | Absorbent and Antibacterial Polystyrene Paper (PSP) Sheet, Method for Producing Thereof and Tray Using the Same - Disclosed are an absorbent and antibacterial polystyrene paper, a method for producing thereof, and an absorbent and antibacterial tray using the same. The absorbent and antibacterial polystyrene paper according to the present invention may be useful to absorb into a paper liquids, such as blood, moisture and the like, which is generated from foods in packing the foods such as meats, fishes, etc., by adding an antistatic agent to polystyrene raw materials and foaming the resultant mixture to produce absorbent and antibacterial polystyrene paper and tray, wherein a plurality of absorption holes are formed on one surface thereof. Here, the absorbent and antibacterial polystyrene paper according to the present invention is produced by mixing, foaming and extrusion-melting 91 to 95% by weight of polystyrene, 2 to 4% by weight of a nucleating material master batch and 3 to 5% by weight of an antistatic agent master batch, wherein a plurality of absorption holes are formed on a surface of a molded sheet. | 2009-04-09 |
| 20090093560 | Polymer composition - A halogenated polymer containing a functionalized polymer and optionally a blowing agent. | 2009-04-09 |
| 20090093561 | Carbon-based materials for respiratory protection - A monolithic, carbonaceous foam suitable for use in respiratory protection is produced by creating an emulsion of a monomer such as vinylidene chloride and/or styrene, a cross-linking agent and a surfactant, curing the emulsion to yield a polymeric foam, sulfonating the foam, and carbonizing the sulfonated foam to yield the monolithic, carbonaceous foam. | 2009-04-09 |
| 20090093562 | CURING RESIN COMPOSITION, SEALING MATERIAL FOR LIQUID CRYSTAL DISPLAY DEVICE AND LIQUID CRYSTAL DISPLAY DEVICE - It is the object of the invention to provide a curable resin composition which causes no liquid crystal contamination, which are excellent in the adhesive property to a glass, and which causes no cell gap inequality in the case it is used as a sealant for a liquid crystal display element to produce a liquid crystal display element by a one drop fill process, a sealant for a liquid crystal display element, and a liquid crystal display element. | 2009-04-09 |
| 20090093563 | DENTAL ADHESIVE AND METHOD OF USE - A dental adhesive composition comprising (i) at least one non-acidic polymerizable monomer having at least one ethylenically unsaturated group, (ii) optionally one or more acidic compounds, (iii) at least one photoinitiator, (iv) at least one solvent, and (v) about 0-40% by weight of one or more fillers; wherein the weight ratio of non-acidic polymerizable monomers/acidic compounds in the adhesive composition is more than about 4.5; the viscosity of the adhesive composition is less than about 350 centipoise (cP) at 25° C.; and the adhesive composition excluding solvent and filler has an acid number of less than about 0.75 mmol NaOH/g. The dental adhesive composition is used with a dental primer composition, which may be provided together in a kit. | 2009-04-09 |
| 20090093564 | Method for forming cured product from photocurable composition and cured product - A method for forming a cured product includes applying a photocurable composition to a base and irradiating the photocurable composition with light from a light source to cure the photocurable composition. The light source is at least one of a fluorescent lamp and a light-emitting diode. The photocurable composition contains a dendritic polymer, a polymerizable compound containing active hydrogen, a photopolymerization initiator, and a hindered amine light stabilizer. | 2009-04-09 |
| 20090093565 | Bio-polymer and scaffold-sheet method for tissue engineering - A method of making a new type of biomaterials, biodegrable crosslinked urethane-containing polyester (CUPE) elastomers and a scaffold-sheet engineering method for tissue engineering applications is provided. CUPEs can be synthesized by forming a linear pre-polymer, which is a polyester, introducing the urethane bonds into polyester using a diisocyanate as a linker, and crosslinking the resulting urethane containing linear polymers to form CUPEs via post-polymerization. This family of polymers, CUPEs, exhibit excellent biocompatibility with desired degradation. Tissue engineering scaffolds made of CUPEs are soft and elastic, and have good mechanical strength. Complex tissue grafts can be constructed by a novel layer-by-layer (LBL) scaffold-sheet engineering design using CUPE sheets. CUPE scaffolds can provide openings for cell to cell communication across scaffold layers and angiogenesis into the depth of the construct. Biomolecules, such as anticoagulants, can be incorporated into the CUPE polymers, increasing their viability as vascular graft scaffolds. | 2009-04-09 |
| 20090093566 | Dental releasing materials - Combining nanosized particles of a source of desired dental restorative, repair or therapeutic materials with strengthening agents in various generally nanosized form such as whiskers, fibers, particles and the like in a resin matrix provides a highly strain resistant composite which more effectively releases the therapeutic agents. The utilization of nano sized particles of the therapeutic agent in the combination enables observation of significantly improved therapeutic results. | 2009-04-09 |
| 20090093567 | RESIN COMPOSITION FOR SHELL MOLD AND RESIN COATED SAND - A resin composition for a shell mold which reduces smoke generation upon molding of a casting mold and maintains a crumbility and a casting mold strength of a phenolic resin, and resin coated sand by the use thereof are provided. The resin composition for the shell mold includes the phenolic resin and an aromatic condensed phosphate ester. The phenolic resin is used as a binder of the resin coated sand used for producing a main mold and a core for shell mold casting of cast iron, cast steel, aluminum, and the like. The aromatic condensed phosphate ester is very effective as a crumbling agent for improving the crumbility of the casting mold after casting. | 2009-04-09 |
| 20090093568 | MULTILAYER POLYMERIC ARTICLE HAVING A METALLIC VARIGATED LOOK - The invention relates to extruded polymeric sheet and articles with an appearance and a texture that can be varied to produce natural-looking variegated materials, that have a metallic or opalescent look. The appearance can simulate natural materials, such as granite, minerals, stone, metal ore. The extruded polymer sheet or article contains at least one polymer composite appearance layer having crosslinked polymer particles and metallic and/or pearlescent materials distributed in a thermoplastic matrix. The thermoplastic matrix can be pigmented or unpigmented. There extruded sheet or article has a transparent thermoplastic cap layer on the side facing the environment. The particle-containing layer can be coextruded in a multi-layer sheet that could include substrate layers and the cap layer. | 2009-04-09 |
| 20090093569 | Novel Dispersant And Compositions Thereof - A composition comprising a particulate Solid, an organic medium and a compound with an alkyleneoxy compound with an inorganic acidic polar head group (Z), wherein the compound is defined by Formula (1) and salts thereof: U—(Y) | 2009-04-09 |
| 20090093570 | ENCAPSULANT COMPOSITION FOR A LIGHT-EMITTING DIODE - An encapsulant composition for a light-emitting diode is provided. One embodiment of the encapsulant composition comprises: (a) about 100 parts by weight of at least one liquid bi-functional epoxy resin containing about 40˜50 weight % of aromatic ring; (b) about 55˜120 parts by weight of a curing agent comprising at least one bi-functional thiol curing agent containing aromatic ring and at least one aliphatic tetra-functional thiol curing agent, wherein the curing agent contains about 10˜50 weight % of aromatic ring and about 20˜35 weight % of sulfur; and (c) about 0.05˜0.5 parts by weight of a catalyst. The encapsulant composition having a high refractive index can be used for a solid state light emitting device to enhance light extraction efficiency. | 2009-04-09 |
| 20090093571 | Synthetic graft having a glass network - A synthetic graft has a glass composition comprises silicon as a network former and Sr as a stable isotope acting as a network modifier. The composition contains calcium as a network modifier and Zn acting as a as either a network modifier or as a network former. The glass composition may be mixed with a solution of polyalkenoic acid to provide advantageous glass polyalkenoate cements (GPCs). These cements are particularly effective for use as bone cements and fillers in the human skeleton as they set at room temperature, have similar strengths to bone, chemically bond to both bone and surgical metal, and release therapeutic ions, which can assist in wound healing and bone re-growth. | 2009-04-09 |
| 20090093572 | Stabilizer mixtures - A stabilizer mixture containing
| 2009-04-09 |
| 20090093573 | Polyester Compositions Which Comprise Cyclobutanediol and at Least One Phosphorus Compound - Described as one aspect of the invention are polyester compositions containing: (I) at least one polyester which comprises: (a) a dicarboxylic acid component comprising: (i) 70 to 100 mole % of terephthalic acid residues; (ii) 0 to 30 mole % of aromatic dicarboxylic acid residues having up to 20 carbon atoms; and (iii) 0 to 10 mole % of aliphatic dicarboxylic acid residues having up to 16 carbon atoms; and (b) a glycol component comprising: (i) 1 to 99 mole % of 2,2,4,4-tetramethyl-1,3-cyclobutanediol residues; and (ii) 1 to 99 mole % of cyclohexanedimethanol residues; and (II) at least one thermal stabilizer chosen from at least one phosphorus compound, reaction products thereof, and mixtures thereof; wherein the total mole % of the dicarboxylic acid component is 100 mole %, and wherein the total mole % of the glycol component is 100 mole %; wherein the inherent viscosity of the polyester is from 0.35 to 1.2 dL/g as determined in 60/40 (wt/wt) phenol/tetrachloroethane at a concentration of 0.25 g/50 ml at 25° C. | 2009-04-09 |
| 20090093574 | Polyester Compositions Containing Cyclobutanediol Having High Glass Transition Temperature and Articles Made Therefrom - Described are polyester compositions comprising at least one polyester which comprises terephthalic acid residues, 2,2,4,4-tetramethyl-1,3-cyclobutanediol, and cyclohexanedimethanol, wherein the inherent viscosity and the Tg of the polyester provides for certain polyester properties. The polyesters may be manufactured into articles such as fibers, films, bottles or sheets. | 2009-04-09 |
| 20090093575 | Resin compositions, method of producing the same and molded article obtained therefrom - Provided are: a first resin composition, which is a polylactic acid-based resin composition containing a polylactic acid resin composition prepared by mixing a polylactic acid resin and a (meth)acrylic acid ester compound in the presence of a peroxide, and a high-strength fiber; and a second resin composition, which contains 70 to 99 parts by mass of a crosslinked biodegradable polyester resin and 1 to 30 parts by mass of an aramid fiber and/or an LCP fiber. In a preferred case, the second resin composition contains 0.01 to 10 parts by mass of a carbodiimide compound with respect to 100 parts by mass of the sum of the crosslinked biodegradable polyester resin and the aramid fiber and/or the LCP fiber. | 2009-04-09 |
| 20090093576 | Appearance Propylene Polymer Composition - Disclosed are propylene polymer compositions comprising a propylene polymer, a polyolefin elastomer, a fluoropolymer, and an optional filler. Said propylene polymer compositions have a good balance of stiffness and toughness, especially low temperature toughness, with improved flow marks and/or gloss in injection molded articles. | 2009-04-09 |
| 20090093577 | IMPACT RESISTANT RIGID VINYL CHLORIDE POLYMER COMPOSITION AND METHOD OF MAKING THE SAME - The instant invention is an impact resistant rigid vinyl chloride polymer composition, and method of making the same. The impact resistant rigid vinyl chloride polymer composition, according to instant invention, includes a vinyl chloride polymer, an impact modifier, and a lubricant system. The impact modifier includes a chlorinated olefin polymer, and an ethylene/alpha-olefin copolymer. The lubricant system includes a first component, a second component, and a third component. The first component is a carboxylic acid selected from the group consisting of stearic acid, lauric acid, myristic acid, palmitic acid, blends thereof, and combinations thereof. The second component is a hydrocarbon wax selected from the group consisting of a paraffin wax, polyolefin wax, blends thereof, and combinations thereof. The third component is a metal soap selected from the group consisting of calcium stearate, aluminum stearate, copper stearate, lithium stearate, magnesium stearate, sodium stearate, zinc stearate, blends thereof, and combinations thereof. The process for preparing the impact resistant rigid vinyl chloride polymer composition of the instant invention includes the following steps: (1) providing a vinyl chloride polymer; (2) providing an impact modifier as described above; (3) providing a lubricant system as described above; (4) blending the vinyl chloride polymer, the impact modifier, and the lubricant system thereby forming the impact resistant rigid vinyl chloride polymer composition. | 2009-04-09 |
| 20090093578 | TRANSPARENT STRETCHED ACRYLIC SHEETS FOR AIRCRAFT WINDOW SYSTEMS HAVING CONTROLLED SOLAR TRANSMITTANCE PROPERTIES - A biaxially stretched transparent acrylic sheet having a controlled solar energy transmittance properties for aircraft window systems is described. The biaxially stretched transparent acrylic sheet includes a thermoplastic acrylic polymer, and from about 0.003 percent by weight to about 0.1 percent by weight of an IR absorbing material, the weight percentage based on the a total weight of the acrylic polymer and the IR absorbing material. The IR absorbing material preferentially absorbs energy having wavelengths from about 700 nm to about 1100 nm. The IR absorbing material is selected from the group consisting of perylene based dyes, nanoparticle hexaboride based IR absorbers, and mixtures thereof. | 2009-04-09 |
| 20090093579 | OXIDE PARTICLE-CONTAINING POLYSILOXANE COMPOSITION AND METHOD FOR PRODUCING SAME - The oxide fine particle-containing polysiloxane composition of the present invention is obtained by mixing (A) silicon oxide fine particles and/or metal oxide fine particles with (B) polyfunctional polysiloxane in an organic solvent in the presence of a basic compound, an acidic compound or a metal chelate compound and thereby dispersing the oxide fine particles (A) in the organic solvent. In the oxide fine particle-containing polysiloxane composition, the oxide fine particles are highly dispersed in the organic solvent without using phosphoric acid or the like having an organic group of 6 or more carbon atoms or a compound having an oxyalkylene group. A polysiloxane-based cured product obtained from such an oxide fine particle-containing polysiloxane composition has excellent transparency and is hardly yellowed even at high temperatures. | 2009-04-09 |
| 20090093580 | RUBBER COMPOSITION AND VIBRATION-PROOF MATERIAL - There is provided a rubber composition containing the following components: (A): an ethylene-α-olefin-nonconjugated polyene copolymer rubber, (B): a natural rubber, (C): an organic peroxide, (D): an aromatic amine compound, and (E): an aluminum-based inorganic compound. | 2009-04-09 |
| 20090093581 | THERMALLY STABLE COMPOSITE MATERIAL FORMED OF POLYIMIDE - A composite material includes a polyimide matrix material and an exfoliated graphite material dispersed within the polyimide matrix material. The composite material exhibits a Thermal Stability Index of at least about 20. | 2009-04-09 |
| 20090093582 | FUNCTIONALIZATION OF CARBON NANOSHPERES BY SEVERE OXIDATIVE TREATMENT - Carbon nanostructures are formed from a carbon precursor and catalytic templating nanoparticles and are treated with a severe oxidative agent to introduce oxygen-containing functional groups to the surface of the graphitic material. Methods for manufacturing carbon nanostructures generally include (1) forming a precursor mixture that includes a carbon precursor and a plurality of catalytic templating particles, (2) carbonizing the precursor mixture to form an intermediate carbon material including carbon nanostructures, amorphous carbon, and catalytic metal, (3) purifying the intermediate carbon material by removing at least a portion of the amorphous carbon and optionally at least a portion of the catalytic metal, and (4) treating the intermediate carbon material with a severe oxidative treatment to increase surface functionalization. Examples of oxidative treatments include (i) a mixture of nitric acid and sulfuric acid, (ii) a solution of hydrogen peroxide, or (iii) a mixture of sulfuric acid and hydrogen peroxide. | 2009-04-09 |
| 20090093583 | LIGHT-DIFFUSING POLYCARBONATE RESIN COMPOSITION AND LIGHT DIFFUSER PLATE COMPRISING THE RESIN COMPOSITION - The present invention provides a light diffusing polycarbonate resin composition including a polycarbonate resin containing a polycarbonate copolymer which comprises a repeating unit represented by the general formula (I) shown below and a repeating unit represented by the general formula (II) shown below, which has a content of the repeating units of the general formula (II) of 1 to 30% by mass and which has a viscosity value of 30 to 71, and (B) a light diffusing agent compounded therein in an amount of 0.01 to 10 parts by mass per 100 parts by mass of the polycarbonate resin. The light diffusing polycarbonate resin composition and a light diffusing plate thereof show improved fluidity during molding and have excellent heat resistance, dimensional stability, luminance and color tone. | 2009-04-09 |
| 20090093584 | End Use Applications Prepared From Certain Block Copolymers - The present invention relates to various end use applications prepared from certain block copolymers. The block copolymers include one or more A or A′ blocks or B blocks plus one or more terminal M blocks. Each A and A′ is a block or segment comprising predominantly a polymerized alkenyl aromatic compound, each B is a block or segment comprising predominantly a polymerized conjugated alkadiene, and each M is a six membered anhydride ring and/or acid group. The anhydride rings are prepared by thermally decomposing adjacent units of (1-methyl-1-alkyl)alkyl acrylic esters such as t-butylmethylacrylate. A wide variety of polymers are disclosed having the stable anhydride rings in the polymer backbone. The invention relates specifically to various end uses prepared from the reaction product of such block copolymers with various reactive resins, reactive monomers and metal derivatives. | 2009-04-09 |
| 20090093585 | ABSORBENT NON-WOVEN FIBROUS MATS AND PROCESS FOR PREPARING SAME - The present invention relates to liquid entrapping devices (e.g., absorbent non-woven fibrous mats) and to a process for preparing such devices. More particularly, the present invention relates to mechanically strong absorbent materials made from such liquid entrapping devices (e.g., non-woven fibrous mats) and to a method for preparing same. In one embodiment, a liquid entrapping device of the present invention comprises at least one hydrophilic elastomeric fibrous component (HEFC) and at least one wetting agent component. In another embodiment, a liquid entrapping device of the present invention comprise at least one hydrophilic elastomeric fibrous component (HEFC), at least one absorbent component, and at least one wetting agent component. In one instance, the wetting agent component of the present invention is contained on and/or within the fibers and/or nanofibers that form the liquid entrapping device (e.g., a non-woven fibrous mat) of the present invention. | 2009-04-09 |
| 20090093586 | ENCAPSULATED COLORANT AND INK COMPOSITION INCLUDING THE SAME - An encapsulated colorant including a colorant and a polymer resin coating the colorant, where the polymer resin is prepared by polymerizing a polymer resin-forming composition including two or more polymerizable unsaturated monomers, and the content ratio of the two or more polymerizable unsaturated monomers is controlled to obtain a glass transition temperature of the polymer resin of −15 to 75° C. An ink composition including an encapsulated colorant, and an ink set comprising two or more types of the ink composition. The encapsulated colorant may have different glass transition temperatures to have a utility of high optical density when printing text, and high gloss when printing images. | 2009-04-09 |
| 20090093587 | MODIFIED BUTYL RUBBER COMPOSITION - A modified butyl rubber composition comprising a butyl rubber modified by mixing, under heating, (a) a compound having a nitroxide-free radical in the molecule thereof, which is stable at an ordinary temperature even in the presence of oxygen, (b) a radical initiator, and (c) a bi- or more-functional radical polymerizable monomer and further by compounded with (d) a bi- or more-functional radical polymerizable monomer, which is different from the ingredient (c). | 2009-04-09 |
| 20090093588 | Solvent Composition - A solvent composition contains a tetralin compound (a) represented by the following general formula (I) and a polyether compound (b) represented by the following general formula (II). The solvent composition is excellent in safety and almost odorless, having a high capability of dissolving various organic materials, and also excellent in affinity to various substrates. The solvent composition is suitably used for various applications including various kinds of paints, adhesives, coating materials, detergents, and the like. | 2009-04-09 |
| 20090093589 | USE OF HYPERBRANCHED POLYCARBONATES AS A DISPERSING AGENT FOR PIGMENTS - Use of high functionality hyperbranched polycarbonates obtainable by | 2009-04-09 |
| 20090093590 | Seal Material for Semiconductor Production Apparatus - A sealing material for a semiconductor manufacturing apparatus includes as rubber components, 80 to 50% by weight of a tetrafluoroethylene-perfluoroalkylvinylether type perfluoro elastomer (FFKM) and 20 to 50% by weight of a fluoroelastomer (FKM) other than FFKM (where FFKM+FKM=100% by weight). | 2009-04-09 |
| 20090093591 | Processing aid for melt-extrudable polymers - An extrudable composition comprising a non-fluorinated, melt processable host polymer and from about 25 parts per million by weight to about 50% by weight, based on total weight of said extrudable composition, of a fluoropolymer consisting essentially of copolymerized units of from 45 to 95 mole percent, based on total weight of said fluoropolymer, of tetrafluoroethylene (TFE) and from 5 and 55 mole percent, based on total weight of said fluoropolymer, of 3,3,3-trifluoropropylene (TFP). | 2009-04-09 |
| 20090093592 | OPHTHALMIC AND OTORHINOLARYNGOLOGICAL DEVICE MATERIALS - Disclosed are soft, high refractive index, acrylic device materials. The materials comprise di-block or tri-block macromers containing hydrophilic side-chains. The materials have improved glistening resistance. | 2009-04-09 |
| 20090093593 | RUBBER COMPOSTITION AND PNEUMATIC TIRE USING SAME - This invention relates to a rubber composition capable of providing high gripping performances without tire performances such as facture properties, wear resistance and the like and a workability in factories when being used in a tire tread as well as a tire using the same, and more particularly to a rubber composition comprising a rubber component and a particular amount of a reaction product obtained by reacting an inorganic metal compound and a phenolic resin at a particular ratio, a rubber composition comprising a rubber component and a combination of an inorganic metal compound and a phenolic resin, and a pneumatic tire using these rubber compositions in a tread member. | 2009-04-09 |
| 20090093594 | RUBBER COMPOSITION FOR TIRE - To provide a rubber composition for a tire increasing the interaction between rubber fillers, low in heat buildup, and able to raise the vulcanization speed. | 2009-04-09 |
| 20090093595 | THERMOSETTING RESIN COMPOSITION CONTAINING LOW CHLORINE POLYFUNTIONAL ALIPHATIC GLYCIDYL ETHER COMPOUND, CURED PRODUCTS OF THE COMPOSITION AND USE THEREOF - An object of the invention is to provide a thermosetting resin composition having excellent low temperature curing properties, tack properties, flexibility and electric properties, cured products made from the composition and uses thereof. The thermosetting resin composition of the invention comprises (A) a thermosetting resin, preferably a carboxyl group containing resin, and (B) a polyfunctional aliphatic glycidyl ether compound having a total chlorine amount of less than 0.7% by mass. The cured products of the thermosetting resin composition is used as insulating protective coating films for printed wiring boards, flexible printed wiring boards, chip on films and the like. | 2009-04-09 |
| 20090093596 | USE OF SILYLATED SULFONATE MONOMERS TO IMPROVE CONTACT LENS WETTABILITY - The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain hydrophilic monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. The polymeric compositions comprise polymerizable hydrophilic siloxanyl monomers. | 2009-04-09 |
| 20090093597 | SYNTHESIS OF PARTICLES IN DENDRITIC STRUCTURES - The invention relates to a method of preparing a particle-based composition, comprising: (i) bringing into contact a mixture comprising a dendritic structure and a metal compound precursor in a fluid, under temperature and pressure conditions such that the mixture is not soluble in the fluid; and (ii) chemically converting the metal compound precursor. | 2009-04-09 |
| 20090093598 | Use of Grafted Polyethersiloxane Copolymers for Improving the Low-Temperature Stability of Antifoams in Aqueous Dispersions - The object of the present invention is to provide antifoams which have a good antifoam effect in aqueous dispersions of polymeric organic substances, cause no wetting defects when these dispersions are applied to a surface and at the same time retain their antifoam activity even after prolonged storage at temperatures down to the freezing point. | 2009-04-09 |
| 20090093599 | CURATIVES FOR EPOXY RESIN, CURING ACCELERATOR, AND EPOXY RESIN COMPOSITION - The present invention has an object to provide curatives for epoxy resins and curing accelerators for epoxy resins, which both have improved subliming and decomposing properties and which, when mixed with an epoxy resin, enable the mixture to be greatly improved in thermal stability that is extremely important for the control of a curing reaction and to have a prolonged pot life (stability as a one-pack mixture comprising the epoxy resin, curative, etc.) and improved curability at low temperatures. The curative is characterized by being a clathrate comprising a tetrakisphenol compound represented by a general formula (I), wherein X represents (CH | 2009-04-09 |
| 20090093600 | Methods for Making Polyester Resins in Falling Film Melt Polycondensation Reactors - The present invention relates to methods for forming polyester resins in one or more falling film reactors. | 2009-04-09 |
| 20090093601 | Photochromic Compounds Comprising Polymeric Substituents And Methods For Preparation And Use Thereof - The present invention relates to a compound comprising a photochromic moiety and at least one substituent comprising a polymer chain having a carbon backbone and a plurality of functional moieties appended to the carbon backbone. | 2009-04-09 |
| 20090093602 | Expandable TFE copolymers, method of making, and porous, expended articles thereof - A process for the polymerization of a true tetrafluoroethylene (TFE) copolymer of the fine powder type is provided, wherein the copolymer contains polymerized comonomer units of at least one comonomer other than TFE in concentrations of at least or exceeding 1.0 weight percent, and which can exceed 5.0 weight percent, wherein the copolymer is expandable, that is, the copolymer may be expanded to produce strong, useful, expanded TFE copolymeric articles having a microstructure of nodes interconnected by fibrils. | 2009-04-09 |
| 20090093603 | OPHTHALMIC AND OTORHINOLARYNGOLOGICAL DEVICE MATERIALS - Disclosed are soft, high refractive index, acrylic device materials. The materials comprise di-block or tri-block macromers containing a hydrophilic block in the polymer backbone. The materials have improved glistening resistance. | 2009-04-09 |
| 20090093604 | OPHTHALMIC AND OTORHINOLARYNGOLOGICAL DEVICE MATERIALS - Disclosed are soft, high refractive index, acrylic device materials. The materials contain a hydrophilic side-chain macromer for glistening resistance. | 2009-04-09 |
| 20090093605 | PROCESS FOR PREPARING A SILICONE RESIN - The invention relates to, and the general field of the invention is that of, the synthesis of silicone resins, more particularly the synthesis of silicone resins of type MQ. The process relates to the preparation of MQ silicone resins and permits better control of the operating conditions in the step of the polymerization of a sodium silicate (B) in aqueous medium in the presence of an acid (C) to form a silica hydrosol (polysilicic acid). In the course of the polycondensation step the reactants, a sodium silicate and an acid, are mixed, preferably in continuous fashion, dynamically to form a mixture (3), by means of at least one intensive mixing tool (M) producing a power ε per unit volume of more than 10 kW/m | 2009-04-09 |
| 20090093606 | Shape memory fibers prepared via wet, reaction, dry, melt, and electro spinning - The present invention relates to methods for synthesizing shape memory polyurethanes, and fibers therefrom. The polyurethanes can be synthesized via solution polymerization or bulk polymerization. Following synthesis, the polyurethanes can be treated via wet spinning, dry spinning, reaction spinning, melt spinning, or electro spinning. | 2009-04-09 |
| 20090093607 | Crosslinked type layered metal phosphonate compound, production process therefor, non-crosslinked type layered metal phosphonate compound, production process therefor, as well as stock solution - A process for producing a crosslinked type or non-crosslinked type layered metal phosphonate compound including a reaction step of reacting two or more members selected from organic diphosphonic acids or monophosphonic acids, or derivatives thereof having predetermined conditions and a metal source capable of forming an ion of a hexacoordinate metal atom as a central atom (M) of a metal oxide octahedron upon reaction under the presence of a sulfuric acid catalyst, a crosslinked or non-crosslinked metal phosphonate compound obtained by the process, as well as a stock solution used for the synthesis of the crosslinked or non-crosslinked type layered metal phosphonate compound described above. | 2009-04-09 |
| 20090093608 | POLYIMIDE MATERIAL WITH IMPROVED THERMAL AND MECHANICAL PROPERTIES - A method of forming a polymeric material includes forming a solution including at least two solvents and at least two diamines. The at least two diamines include oxydianiline (ODA) in an amount of about 50% to about 90% based on the total moles of the at least two diamines and include m-phenylenediamine (MPD) in an amount of about 10% to about 50% based on the total moles of the at least two diamines. The at least two solvents include a high polarity solvent in an amount of about 40% to about 90% based on the total weight of the at least two solvents and include a low polarity solvent in an amount of about 10% to about 60% based on the total weight of the at least two solvents. The method further includes adding pyromellitic dianhydride (PMDA) to the solution in a ratio of about 0.9 to about 1.05 based on the total moles of the at least two diamines to form a polyamic acid solution. In addition, the method includes imidizing the polyamic acid solution to form a polyimide material. | 2009-04-09 |
| 20090093609 | Polyvinyl Acetal-Based Resin - The present invention provides a polyvinyl acetal-based resin which has a high elastic modulus, is excellent in solubility to an alcoholic solvent, and gives a highly transparent alcohol solution. The polyvinyl acetal-based resin is obtained by acetalizing a polyvinyl alcohol-based resin (A) which has 0.1 to 1.5% by mol of a 1,2-diol structural unit represented by the following general formula (1) and a degree of saponification of 98.5% by mol or more: | 2009-04-09 |
| 20090093610 | Catechol Functionalized Polymers and Method for Preparing Them - Described are compounds that are capable of forming adlayers, the compounds comprising at least one headgroup A, an optional linker B, a polymer C, a terminal group D and an optional crosslinking group R, wherein
| 2009-04-09 |
| 20090093611 | Epoxy/modified silicon dioxide corrosion resistant nanocomposite material and preparation method thereof - An epoxy/modified silicon dioxide corrosion resistant nanocomposite material and a preparation method thereof are disclosed. The method includes the steps of: dispersing TS(TEOS-SiO | 2009-04-09 |
| 20090093612 | AMIDE-SUBSTITUTED XANTHENE DYES - The present invention provides amide-substituted xanthene fluorescent dyes and reagent for the introduction of phosphonate or sulfo groups into the fluorescent dyes. | 2009-04-09 |
| 20090093613 | Treatment of tinnitus - The invention relates to the use of substances which are at least partly blocking one ionotropic acetylcholine receptor of the inner ear and/or a calcium-activated potassium channel functionally associated with said acetylcholine receptor of the inner ear for the manufacturing of a pharmaceutical composition or medicament for the treatment of tinnitus. | 2009-04-09 |
| 20090093614 | SELF-ASSEMBLED PROTEINS AND RELATED METHODS - The present invention provides user-directed construction of novel specific homo- and hetero-dimeric, and multimeric assemblages of proteins. The present invention is comprised of a family of peptide sequences that forms links between proteins, where the peptide sequences produce a hook or loop which supports specific self-assembly of dimers of the proteins to which they are attached. The hook or loop may have a short aliphatic repeat and a metal binding loop. Also provided is a method of constructing a hook motif of metal binding loop sequences attached to at least one aliphatic carbon sequence to produce homo-dimeric, hetero-dimeric and multimeric assemblages of proteins. | 2009-04-09 |
| 20090093615 | METASTIN DERIVATIVES AND USE THEREOF - The present invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, a gonadotrophic hormone secretion stimulating activity, sex hormone secretion stimulating activity, etc.). By substituting the constituent amino acids of metastin with specific amino acids in the metastin derivative of the present invention, blood stability, solubility, etc. are more improved, gelation tendency is reduced, pharmacokinetics are also improved, and an excellent cancer metastasis suppressing activity or a cancer growth suppressing activity is exhibited. Furthermore, the metastin derivative of the present invention has the effects of suppressing gonadotropic hormone secretion, suppressing sex hormone secretion, etc. | 2009-04-09 |
| 20090093616 | IN-SOLUTION ACTIVATION OF FACTOR VII - The present invention is directed to a method for activation of Factor VII to FVIIa in solution. | 2009-04-09 |
| 20090093617 | Crystals of whole antibodies and fragments thereof and methods for making and using them - This invention relates to crystals of whole antibodies and fragments thereof, and formulations and compositions comprising such crystals. More particularly, methods are provided for the crystallization of high concentrations of whole antibodies, and fragments thereof, in large batches, and for the preparation of stabilized whole antibody crystals for use alone, or in dry or slurry formulations or compositions. This invention also relates to methods for stabilization, storage and delivery of biologically active whole antibody crystals. The present invention further relates to methods using whole antibody crystals, antibody fragment crystals, or compositions or formulations comprising such crystals for biomedical applications, including biological delivery to humans and animals. More particularly, whole antibody crystals or antibody fragment crystals, or crystal compositions or formulations thereof, are used as a carrier-free delivery system which can slowly release active whole antibodies or fragments thereof, to a subject, where and when they are needed. | 2009-04-09 |
| 20090093618 | STREPTAVIDIN-BIOTIN-LINK ANTIBODY-HAPTEN SYSTEM - The present invention provides antibodies comprising an antigen recognition domain that specifically binds to a metal chelate: mutant antibodies comprising a reactive site not present in the wild-type of the antibody, wherein the reactive site is in a position proximate to or within the antigen recognition domain; and methods of using such antibodies to diagnose and treat disease. | 2009-04-09 |
