| 15th week of 2009 patent applcation highlights part 31 |
| Patent application number | Title | Published |
|---|
| 20090092917 | TONER, DEVELOPER, AND IMAGE FORMING METHOD - A toner including a binder resin including a polyester resin, a colorant, and a release agent including a polyglycerin ester having a melt viscosity of from 1.0 to 40 mPa·sec at 120° C. and a hydroxyl value of from 0 to 100 mgKOH/g is provided. The polyglycerin ester is an ester of a polyglycerin having an average polymerization degree of from 2 to 10 and an aliphatic acid having 16 to 24 carbon atoms in average. | 2009-04-09 |
| 20090092918 | Grafting Metal Oxides Onto Polymer for Toner - Toner particles, including at least one binder, at least one colorant, and at least one metal surface additive, wherein the at least one metal oxide surface additive is a metal oxide particle covalently bonded with at least one polycondensation polymer. | 2009-04-09 |
| 20090092919 | MAGNETIC TONER - To provide a magnetic toner which has superior low-temperature fixing performance and pressure roller anti-staining properties even in various forms of use, has been kept from image defects such as image non-uniformity even during long-time image reproduction and can achieve high-level image quality. In a magnetic toner having toner particles containing at least a binder resin and a magnetic material, the activation energy Ea (kJ/mol) that is determined from a shift factor aT | 2009-04-09 |
| 20090092920 | CARRIER, DEVELOPER, IMAGE FORMING METHOD AND PROCESS CARTRIDGE - The present invention is to provide a carrier and a developer, which have fewer occurrences of carrier adhesion and background smear, excellent granularity and longer durability. The carrier comprises the core material particles having magnetism and resin coating layer covering the core material particles, and wherein the weight average particle diameters is in the range of 22 m to 32 m, the proportion of the weight average particle diameters relative to the number average particle diameter is in the range of 1.00 to 1.20, the content of particles having a diameter of 20 m or smaller is 7% by mass, the content of carrier particles having a diameter of 36 m or smaller is in the range of 90% by mass to 100% by mass, and the proportion of the particle density of the core material particles is in the range of 85% to 100% of the true density of the core material particles. | 2009-04-09 |
| 20090092921 | POSITIVE RESIST COMPOSITION AND RESIST PATTERN FORMING METHOD - A positive resist composition includes a base material component (A) which exhibits increased alkali solubility under an action of an acid, and an acid generator component (B) which generates an acid upon exposure, wherein the base material component (A) contains a compound (A1) in which phenolic hydroxyl groups in a polyhydric phenol compound (a) containing two or more phenolic hydroxyl groups and having a molecular weight of 300 to 2,500 are protected with acid dissociable, dissolution inhibiting groups, and the compound (A1) exhibits a standard deviation (s | 2009-04-09 |
| 20090092922 | Imaging Layers, Structures Including Imaging Layers, Methods of Making Imaging Layers, and Imaging Systems - Imaging layers, image recording media, and methods of preparation of each, are disclosed. | 2009-04-09 |
| 20090092923 | MODIFIED SILICA PARTICLES, AND PHOTOSENSITIVE COMPOSITION AND PHOTOSENSITIVE LITHOGRAPHIC PRINTING PLATE EACH CONTAINING THE PARTICLES - An object of the present invention is to satisfactorily maintain adhesion between a photosensitive layer and a substrate after the exposure of the photosensitive lithographic printing plate. | 2009-04-09 |
| 20090092924 | METHOD OF PRODUCING POSITIVE RESIST COMPOSITION, POSITIVE RESIST COMPOSITION, AND METHOD OF FORMING RESIST PATTERN - A method of forming a positive resist composition of the present invention includes a step (I) of passing a positive resist composition, which is obtained by dissolving a resin component (A) that displays increased alkali solubility under the action of acid and an acid generator component (B) that generates acid upon exposure in an organic solvent (S), through a filter (f | 2009-04-09 |
| 20090092925 | Projection optical system, exposure apparatus, and exposure method - An immersion projection optical system that prevents leakage of a liquid (immersion liquid) into the optical system and maintains satisfactory imaging capability. The projection optical system of the present invention is a projection optical system that projects a reduced image of a first plane onto a second plane through a liquid. The projection optical system includes an interface optical lens (Lb) having a side towards the first plane that contacts a gas and a side towards the second plane that contacts the liquid. The interface optical element includes a light entering surface (Lba), which has a convex shape facing towards the first plane, and a groove (Gr), which is formed to surround an effective region in a light emitting surface of the interface optical element. | 2009-04-09 |
| 20090092926 | Lithography Systems and Methods of Manufacturing Using Thereof - Multi-beam lithography systems and methods of manufacturing semiconductor devices using the same are disclosed. For example, the method utilizes non-coincidence of boundaries of electrical fields emanating from chrome on glass or phase shifted mask features distributed over two masks for the optimization of lithographic process windows, side lobe suppression, or pattern orientation dependent process window optimization employing one mask with polarization rotating film on the backside. | 2009-04-09 |
| 20090092927 | IMAGE DRUM AND FABRICATING METHOD THEREOF - A method of fabricating an image drum includes preparing a hollow drum body having a slot extending in a longitudinal direction, preparing a printed circuit board (PCB) having a plurality of board terminals, mounting the PCB inside the hollow drum body with a fixing member such that the board terminals of the PCB are placed in the slot of the hollow drum body, coating a first insulating layer on an outer circumference of the hollow drum body, forming a plurality of ring electrodes on the first insulating layer corresponding to the board terminals of the PCB, in which a portion of ring electrodes which corresponds to the board terminals of the PCB is non-continuous, exposing the board terminals below non-continuous area of the ring electrodes by etching the first insulating layer with the ring electrodes as an etching mask, and forming a connecting electrode to electrically connect the board terminals to the ring electrodes. | 2009-04-09 |
| 20090092928 | COMPONENT FABRICATION USING THERMAL RESIST MATERIALS - A method for producing a patterned material for electronic or photonic circuits, comprising the steps of: | 2009-04-09 |
| 20090092929 | PIEZOELECTRIC-ACTUATOR DRIVING DEVICE AND EXPOSURE APPARATUS INCLUDING THE SAME - A driving device includes a plurality of laminated units formed by alternately stacking piezoelectric element layers and electrode layers, a failure detecting unit configured to detect failure of the laminated units, a plurality of switches provided corresponding to the laminated units and configured to enable and disable current supply to the laminated units, and a driving circuit configured to supply a current for driving to a normal laminated unit of the laminated units, on the basis of an output from the failure detecting unit. | 2009-04-09 |
| 20090092930 | PATTERN FORMATION METHOD - After forming an underlying layer film and an intermediate layer film are formed over a substrate, a resist pattern formed by first pattern exposure using a first resist film and second pattern exposure using a second resist film is transferred onto the intermediate layer film. Furthermore, the underlying layer film is etched using the intermediate layer pattern as a mask, thereby obtaining an underlying layer film pattern. The underlying layer film includes as an adduct a fluorine-based surfactant or inorganic nano particles and is provided with a resistance against oxygen-based plasma. | 2009-04-09 |
| 20090092931 | Methods of forming a blocking pattern using a photosensitive composition and methods of manufacturing a semiconductor device - A method of forming a blocking pattern includes forming a preliminary blocking layer on first and second regions of a substrate, the preliminary blocking layer being formed of a photosensitive composition including a siloxane polymer, a cross-linking agent, a photoacid generator, and a thermal acid generator, selectively exposing to light a first portion of the preliminary blocking layer, the first portion of the preliminary blocking layer being formed on the first region of the substrate, such that a cross-linked pattern is formed on the first region of the substrate, and removing a second portion of the preliminary blocking layer, the second portion of the preliminary blocking layer being formed on the second region of the substrate. | 2009-04-09 |
| 20090092932 | METHOD FOR FORMING PATTERN - In an exposure step, a combination of a first photomask and a second mask is used. The first mask has a real pattern corresponding to the pattern actually formed on the film to be processed, and a dummy pattern added for controlling pattern pitch in the first photomask within a prescribed range; and the second photomask has a pattern isolating a real-pattern-formed region from a dummy-pattern-formed region. In forming the pattern, after forming a film to be processed on a substrate, a first mask is formed on the film to be processed, by lithography, using the first photomask, and a second mask is formed on the film to be processed, by lithography, using the second photomask. Thereafter, the film to be processed is etched and removed using the first and second masks as masks to form the pattern. | 2009-04-09 |
| 20090092933 | Methods of Lithographically Patterning a Substrate - A method of lithographically patterning a substrate that has photoresist having removal areas and non-removal areas includes first exposing at least the non-removal areas to radiation effective to increase outer surface roughness of the photoresist in the non-removal areas at least post-develop but ineffective to change photoresist solubility in a developer for the photoresist to be cleared from the non-removal areas upon develop with the developer. Second exposing of radiation to the removal areas is conducted to be effective to change photoresist solubility in the developer for the photoresist to be cleared from the removal areas upon develop with the developer. The photoresist is developed with the developer effective to clear photoresist from the removal areas and to leave photoresist in the non-removal areas that has outer surface roughness in the non-removal areas which is greater than that before the first exposing. Other implementations and embodiments are contemplated. | 2009-04-09 |
| 20090092934 | GRAY-TONE LITHOGRAPHY USING OPTICAL DIFFUSERS - A method of: directing an exposing light through an optical diffuser; directing the diffused light though a photomask having transparent areas corresponding to a gray-tone pattern; directing the masked light onto a photoresist material on a substrate; developing the photoresist to produce a three dimensional structure in the photoresist. | 2009-04-09 |
| 20090092935 | Method for effective degassing of wicks - A process for degassing or presoaking wicks used in the manufacturing of candles. Spools of raw wick are placed in a wax bath. The door to the vacuum chamber is then closed and the pressure in the chamber is reduced. The reduction of the pressure forces wax into the wick fiber to ensure complete saturation of the wick. | 2009-04-09 |
| 20090092936 | PRESSURE REGULATOR WITH BLEED ORIFICE - A pressure regulator having a housing that defines a gas inlet, a gas outlet, and a reference pressure connector. A diaphragm is provided in the housing, where the diaphragm defines, at least in part, a reference pressure chamber. In some illustrative embodiments, the reference pressure connector fluidly references the reference pressure chamber to a first pressure via a first orifice, and to a second pressure via a second bleed orifice. A gas valve incorporating a pressure regulator is also disclosed. | 2009-04-09 |
| 20090092937 | Electronic Gas Control System - An electronic gas control apparatus including a variable flow valve, an igniter, a flame sensor, and an electronic controller is provided. The valve has a flow range that equals or exceeds a required flow range for any one of the types of gas suitably combusted by the burner. The electronic controller is operably coupled to each of the valve, the igniter, and the sensor. The electronic controller is configured to activate the igniter, to receive a flame status signal from the sensor, and to recognize a position of the valve when the flame status signal indicates a flame at the burner. As such, the electronic controller is calibrated for the gas, line-pressure, jet and burner configuration being used. | 2009-04-09 |
| 20090092938 | Candle maker and redresser - A used candle is held against a flat electrically heated wax melting surface for removing the shoulder and the crater from the candle. The melted wax is directed through a drain to a container. The melted wax may be poured into a separate candle mold, or the container may be used directly to form a new candle. A multi legged wick pin holder, placed across the top of the container, holds one or more wick pins in vertical position when the container is used as a candle mold. The wax melting surface is angled slightly toward the drain to facilitate the flow of melted wax. A low heat conducting barrier keeps chunks of wax from clogging the drain. In one embodiment, the wax melting surface includes a gutter that communicates with a well formed around the drain. The well has tapered sides for shaping candle bottoms. In another embodiment, the wax melting surface has multiple angled planes converging at the drain. | 2009-04-09 |
| 20090092939 | TORCH AND CANISTER - A fuel canister is provided comprising a vessel for containing a fuel. A fitment is located in a wall of the vessel and a gripping portion is located in another wall of the vessel. The gripping portion may include a rib formed by raised and recessed areas. The rib may also reinforce the wall of the canister. A torch is also provided comprising a torch body that is releasably connected to the fuel canister. A method of making a fuel canister is also provided comprising forming a vessel having a top wall and a side wall. The bottom wall is formed having at least one portion defining a flat or nearly flat surface. The bottom wall is welded or brazed to the side wall. External ribs may be formed in the bottom wall. | 2009-04-09 |
| 20090092940 | Processing system for process object and thermal processing method for process object - To provide a processing system for a process object capable of preventing a transport arm mechanism from being thermally damaged, so as to effectively perform a transport operation of the process object. A processing system | 2009-04-09 |
| 20090092941 | DEVICES AND METHODS FOR HEATING PIPES OR TUBING - The subject invention provides devices and methods for heating pipes, tubing or similar equipment. More specifically, the subject invention pertains to devices and methods for heating pipes, tubing or similar equipment to melt-out blockages, such as for example, bitumen blockages. | 2009-04-09 |
| 20090092942 | INJECTION IMPRESSION TRAY - The present invention relates to an improved dental impression tray and related methods. In one embodiment, a dental impression tray includes a first portion for receiving impression material from a source and a second portion is configured for receiving a patient's upper or lower teeth and will at least partial define a cavity shaped to receive the teeth during use. In use, impression material introduced into the first portion can pass through openings and into the second portion and around a patient's teeth. | 2009-04-09 |
| 20090092943 | METHOD FOR MANUFACTURING METAL WITH CERAMIC COATING - A method for manufacturing a coated implant, the method comprising depositing in electrophresis at least one ceramic layer on at least a portion of the body of the implant; and sintering said at least one ceramic layer using optical radiation. | 2009-04-09 |
| 20090092944 | Tooth Implant - The invention concerns a non rotation-symmetric but root-analogue or tooth socket-analogue dental implant of the same size and shape as the root of the extracted tooth with macro retentions protruding from the implant surface ( | 2009-04-09 |
| 20090092945 | NON-CONTACT APPARATUS AND METHOD FOR STABILITY ASSESSMENT OF DENTAL IMPLANT - A non-contact apparatus for a stability assessment of a dental implant is provided. The non-contact apparatus includes a triggering device and a dental implant containing a root body and an impact generating device, wherein the root body has a cavity, the impact generating device is located in the cavity, and the triggering device provides a non-contact impetus for triggering the impact generating device. | 2009-04-09 |
| 20090092946 | Method of generating a digital supplementary device for dental implant planning - A method of generating a digital supplementary device for dental implantation by: preparing a mouth model based on the internal shape of the oral cavity of the patient; performing a 3D scan to obtain digital model of the mouth model, the digital model of the patient's oral cavity and the digital model of the tooth model; defining the digital models as the “positioning object,” “the reference object” and the “attached positioning object”; obtaining characteristic points after joining the positioning object and the attached positioning object and positioning the positioning object and the reference object based on the characteristic points; and then outputting the attached positioning object with the positioning data obtained after positioning of the attached positioning object. The output thus obtained is the desired digital supplementary device for dental implant planning. | 2009-04-09 |
| 20090092947 | Laser curettage - Laser ablation is used in curettage to treat periodontal disease. After an initial step of ablating afflicted tissues, an anti-microbial rinse is applied. A flexible fiber optic guide is the preferred means of directing radiant energy to the afflicted tissues. Sulcular disinfection may also be achieved by similar associated processes. Various anti-microbial agents and laser sources are disclosed. | 2009-04-09 |
| 20090092948 | ASSISTED DENTAL IMPLANT TREATMENT - Embodiments of systems and methods for planning and/or delivering an oral or facial endosseous implantation in a patient are described. In certain embodiments, systems according to the invention include a processing module; a bone imaging module that communicates bone data about the patient to the processing module; a surface imaging module that communicates surface data about the patient to the processing module; and the processing module processes the bone data and the surface data into an output that includes three-dimensional (3-D) representation data indicative of at least one of an oral structure and a facial structure of the patient. In certain embodiments, a system includes a fabrication module that produces a physical model based on the 3-D representation data and indicating a planned location of an endosseous implant. In certain embodiments, a system includes a surgical module that guides implantation of an endosseous implant based on the 3-D representation data. | 2009-04-09 |
| 20090092949 | SYSTEM FOR USE WITH A DROPLET CLEANING DEVICE FOR CLEANING AN IMPACT AREA FOR THE DROPLETS - The clearing system for fluid droplets includes a source of air ( | 2009-04-09 |
| 20090092950 | DENTIN ANCHOR - A fiber-reinforced composite (FRC) dentin anchor is disclosed comprising a coronal portion, to which a tooth restorative material may be secured, and a dentinal portion, adapted to be received in a pre-drilled hole in tooth dentin. The dentinal portion may be adapted to chemically bond to the tooth without the use of threads and the coronal portion may be adapted to chemically bond to a tooth restoration without the use of additional adhesives. The dental anchor may includes an intermediate portion having a shape and size that is different from the shape and size of the dentinal portion and the coronal portions and be adapted to be received entirely or partially within the pre-drilled hole in the tooth dentin. The modulus of elasticity of the dentin anchor may approximate the modulus of elasticity of tooth dentin. | 2009-04-09 |
| 20090092951 | SENSING TYPE LEARNING CARD AND LEARNING SYSTEM THEREOF - The invention discloses a sensing type learning card and a learning system including the card and a card reader. The sensing type learning card includes at least one card body and at least one identification label. The card reader includes a platform with a defined card disposing area, at least one sensing unit installed at the platform, at least one display unit installed on the card disposing area, a storage unit for storing at least one learning data, and a processing unit. The card body includes a transparent area. The identification label stores an identification data. If the sensing type learning card is disposed on the card disposing area, the sensing unit senses the identification label to read the identification data, and the processing unit inquires a learning data corresponding to the identification data from the storage unit, and drives the display unit to display the inquired learning data. | 2009-04-09 |
| 20090092952 | Apparatus for Touch-Sensitive Visual and Audible Identification - An apparatus for visual and audible identification includes a display region for displaying a written name of an object. A speaking module pronounces a spoken name of the object when activated. An activation switch activates the speaking module. An attachment unit couples the apparatus to the object. | 2009-04-09 |
| 20090092953 | Encoding, Storing and Decoding Data for Teaching Radiology Diagnosis - Electronic data for presenting images to teach radiology diagnosis are stored on a computer readable storage medium. The stored data includes an image table that includes indexed radiology images to be displayed; a frame table that includes frame entries, each for displaying a frame in a sequence of frames to be displayed and comprising a time indicator indicating a time to display the frame in the sequence, and display state data indicating a display state of one of the radiology images to be displayed in the frame; at least one annotation table including data defining teaching annotations to be superimposed on at least one radiology image. Each frame entry is associated with a radiology image and each annotation table is associated with a frame entry. An encoder/decoder is provided for encoding and storing the data in a file and for decoding and presenting images formed from the data. | 2009-04-09 |
| 20090092954 | Recording interactions - The recording of an interaction between an authorised host and at least one subject, for use in reinforcing good behaviour of the subject, is disclosed. A counsellor is hosted at a central station and subjects are received at one or more counselling stations. The central station and the subject receiving stations are connected by a network. An interaction between a subject and an authorised host is recorded and the authorised host adds related textural data to a relational database. | 2009-04-09 |
| 20090092955 | Tooth brushing pattern analyzing/modifying device, method and system for interactively modifying tooth brushing behavior - Disclosed are a toothbrushing pattern analyzing/correcting device, a toothbrushing pattern analyzing/correcting method, a method and a system for interactively correcting toothbrushing behavior. The toothbrushing pattern analyzing/correcting device of the present invention includes: a body part formed in the same direction as a toothbrush surface; a sensing unit having a sensor with at least one or more axes for sensing a user's toothbrushing motion and a sensor with one or more axes for sensing two or more toothbrushing positions; and a controller for operating signals input from the sensing unit to classify a user's toothbrushing motion into at least two or more patterns and at least two or more toothbrushing parts. Further, the toothbrushing pattern analyzing/correcting method includes the steps of: detecting the start of a user's toothbrushing; displaying a guiding screen in response to the start of a user's toothbrushing; detecting a user's toothbrushing pattern; analyzing the user's detected toothbrushing pattern; and providing a toothbrushing correction screen with the intention of increasing compliance in accordance with the analyzed result. Accordingly, toothbrushing behavior correction compliance can be further enhanced with a method of interactively correcting a user's toothbrushing behavior through multimedia image substances in real time, and more systematic management and health consultation are possible by building a database of information of the user's toothbrushing behavior. | 2009-04-09 |
| 20090092956 | Experiment and education system employing a plurality of units - When a mechanism constituent unit having a base is secured to a magnetic base at a predetermined position, a fixture having a detachable mechanism inside itself is employed, and the fixture is disposed on a notch of the base of the mechanism constituent unit in a non-adsorption state in which magnetic force lines of a permanent magnet of the detachable mechanism permeate the fixture. In this state, a rotation casing is rotated 90 degrees to be in a lock state, and a fixing casing is firmly adsorbed to the magnetic base such that magnetic force of the permanent magnet inside it permeate to the magnetic base side. Thus, the mechanism constituent unit base is firmly sandwiched by a pressing portion of the fixing casing and the magnetic base, and the base of the mechanism constituent unit is firmly secured to the magnetic base at a predetermined position. | 2009-04-09 |
| 20090092957 | FINGER ERASER - An eraser for use in erasing markings on boards, such as chalk boards and white boards, is provided. The eraser comprises a form-fitted finger element made from a knitted or felted fabric. The finger element consists of a tubular member that defines a longitudinally extending finger passage. The tubular member has one open end and one closed end. The open end is sized such that the finger of the eraser user is insertable through the open end, so that at least a portion of the finger is received within the finger element passage. | 2009-04-09 |
| 20090092958 | Method of Inactivating Blood Coagulation Factor and Blood Coagulation Factor-Inactivated Sample - A method of inactivating a blood coagulation factor is described. The method comprises a step of contacting a sample containing at least one of factors V and VIII with a compound having an iminodiacetate group, whereby at least one of factors V and VIII in the sample is changed into an inactivated form. | 2009-04-09 |
| 20090092959 | Nucleic acid and allergenic polypeptides encoded thereby in cashew nuts - The invention describes an isolated nucleic acid sequence comprising the nucleotide sequence of SEQ ID NO:1 or a degenerate variant of SEQ ID NO: 1. The nucleic acid sequence encodes an Ig-E binding immunogenic polypeptide the amino acid sequence of which comprises at least one sequence selected from SEQ ID NOS:4-25. The invention additionally provides an in vitro diagnostic test for detecting anti-cashew IgE in a patient. The test comprises reacting the patient's serum with a purified polypeptide the amino acid sequence of which comprises at least one sequence selected from SEQ ID NOS:3-25; separating the polypeptide from unreacted patient serum; reacting the polypeptide with a labeled human IgE-reactive agent after separating from unreacted patient serum; separating the polypeptide from unreacted labeled human IgE-reactive agent; and detecting labeled human IgE-reactive agent bound to the polypeptide after separating from unreacted agent to thereby indicate presence in the patient's serum of anti-cashew IgE. | 2009-04-09 |
| 20090092960 | Novel Fluorescent and Colored Proteins, and Polynucleotides that Encode These Proteins - The subject invention provides new fluorescent and/or colored proteins, and polynucleotide sequences that encode these proteins. The subject invention further provides materials and methods useful for expressing these detectable proteins in biological systems. | 2009-04-09 |
| 20090092961 | IDENTIFICATION AND MODIFICATION OF DYNAMICAL REGIONS IN PROTEINS FOR ALTERATION OF ENZYME CATALYTIC EFFECT - A method for analysis, control, and manipulation for improvement of the chemical reaction rate of a protein-mediated reaction is provided. Enzymes, which typically comprise protein molecules, are very efficient catalysts that enhance chemical reaction rates by many orders of magnitude. Enzymes are widely used for a number of functions in chemical, biochemical, pharmaceutical, and other purposes. The method identifies key protein vibration modes that control the chemical reaction rate of the protein-mediated reaction, providing identification of the factors that enable the enzymes to achieve the high rate of reaction enhancement. By controlling these factors, the function of enzymes may be modulated, i.e., the activity can either be increased for faster enzyme reaction or it can be decreased when a slower enzyme is desired. This method provides an inexpensive and efficient solution by utilizing computer simulations, in combination with available experimental data, to build suitable models and investigate the enzyme activity. | 2009-04-09 |
| 20090092962 | METHOD FOR DETECTING SARS CORONAVIRUS - This invention provides: a method for detecting SARS pathogenic viruses with high sensitivity and rapidity for diagnosing severe acute respiratory syndrome (SARS); an oligonucleotide primer that can specifically hybridize with any nucleotide sequence constructed based on the nucleotide sequence of RNA polymerase of the SARS coronavirus; a method for nucleic acid amplification using such primer; a method for diagnosing infection with the SARS coronavirus via detection of nucleic acid amplification; and a kit for diagnosing SARS. | 2009-04-09 |
| 20090092963 | Method for combined parallel agent delivery and electroporation for cell structures an use thereof - Disclosed is a method for parallel delivery of agents to and/or into a cell structure, wherein at least two electrolyte-filled tubes are provided together with a counter electrode, the tubes being connected to a voltage or current generator, said agents being introduced into the electrolyte solution contained in the tubes, which are placed close to the cell structure, whereupon the agents are transported through the tubes to said cell structure and into the said structure through pores which have been formed by application of an electric field focused on the cell structure, resulting in electroporation of the cell structure. Also different applications of the method is disclosed, e.g. use of the method in order to transfer cell-impermeant solutes, such as drugs or genes, into the cell structure or out of the cell structure. | 2009-04-09 |
| 20090092964 | Methods for Individualizing Cardiovascular Disease Treatment Protocols Based on Beta-1 Adrenergic Receptor Haplotype - A method is provided for determining whether a treatment protocol for a human patient who is suffering from heart failure, ischemic heart disease, cardiac arrhythmias, or hypertension includes administration of a beta blocker, the method including obtaining a biological sample from the patient, determining a β | 2009-04-09 |
| 20090092965 | Method and Apparatus for Target Detection Using Electrode-Bound Viruses - A biosensor capable of detecting the presence and/or concentration of an analyte or biomarker includes at least one electrically conductive electrode operatively coupled to an impedance analyzer for measuring the change in the resistive impedance of the electrode in response to an applied alternating current at a plurality of frequencies. In one embodiment, at least one electrode is covered with a self-assembled monolayer that is chemically bonded to a surface. A plurality of virus particles such as phage viruses are immobilized on the self-assembled monolayer and may be exposed to a test or sample solution. The virus particles may be obtained from phage-displayed libraries to detect a wide variety of targets including, for example, DNA, RNA, small molecules, and proteins or polypeptides. In another embodiment, the virus particles are electrostatically bound to a substrate in between a pair of elongated electrodes disposed on a substrate. | 2009-04-09 |
| 20090092966 | COLLOIDAL METAL AGGREGATES AND METHODS OF USE - Metal colloidal aggregates substrates useful for metal enhanced fluorescence applications, are disclosed. Method of making and using these colloidal aggregates for enhancing the fluorescent signal in biological assays are also described. | 2009-04-09 |
| 20090092967 | METHOD FOR GENERATING TARGET NUCLEIC ACID SEQUENCES - The present invention provides methods of generating target nucleic acids for amplification using nicking enzymes and methods for amplifying the generated target nucleic acids. | 2009-04-09 |
| 20090092968 | SCREENING METHOD FOR MYCOBACTERIA IN METAL REMOVAL FLUID SYSTEMS - One embodiment of the invention includes a method for testing a fluid for contamination by a mycobacterial organism. A plurality of individual standardized samples may be acquired from a plurality of predetermined sampling points and pooled into a pooled sample. The pooled sample may be analyzed using a polymerase chain reaction technique and the results compared against a pool concern level which is calculated from an individual concern level that governs each individual standardized sample. | 2009-04-09 |
| 20090092969 | DETECTION OF ATYPICAL PNEUMONIA - Disclosed herein are methods and compositions for detecting one or more pathogens that cause atypical pneumonia. Detectable pathogens include | 2009-04-09 |
| 20090092970 | COMPOSITION AND METHOD FOR NUCLEIC ACID SEQUENCING - The present invention provides compositions and methods for detecting incorporation of a labeled nucleotide triphosphate onto the growing end of a primer nucleic acid molecule. The method is used, for example, to genotype and sequence a nucleic acid. In a preferred embodiment, the method described herein detects individual NTP molecules. | 2009-04-09 |
| 20090092971 | Method for Detecting p53 Dysfunction, Method for Molecular Diagnosis of Cancer and Method for Evaluating Compound Effective in Treating Cancer - The present invention relates to methods for detecting a dysfunctional cancer suppressing gene, particularly p53. In other aspects, the invention provides methods for diagnosing cell proliferative disorders such as cancer by measuring expression of a predetermined target gene. Methods of evaluating the efficacy of a test compound to treat a cell proliferative disorder are also included. Such methods generally rely on the expression levels of a predetermined or targeted gene. | 2009-04-09 |
| 20090092972 | Method of evaluating drug sensitivity by analyzing girk channel genes - A method of evaluating drug sensitivity or disease vulnerability, includes linking a gene polymorphism in a GIRK channel gene or a haplotype comprising the gene polymorphism to individual drug sensitivity or individual disease vulnerability. | 2009-04-09 |
| 20090092973 | Grading of Breast Cancer - Methods and compositions for the identification of breast cancer grade signatures are provided. The signature profiles are identified based upon multiple sampling of reference breast tissue samples from independent cases of breast cancer and provide a reliable set of molecular criteria for identification of cells as being in one or more particular stages and/or grades of breast cancer. | 2009-04-09 |
| 20090092974 | Micrornas differentially expressed in leukemia and uses thereof - The present invention concerns methods and compositions for identifying a miRNA profile for acute myeloid leukemia (AML), and using the profile in assessing the condition of a patient. | 2009-04-09 |
| 20090092975 | SELECTABLE MARKER - A nucleic acid sequence encoding a decarboxylation enzyme E.G. PAD1 is used as a selectable marker in a recombinant organism. A weak acid is used as the selecting agent. | 2009-04-09 |
| 20090092976 | Hypermethylation of GATA-4 and GATA-5 Transcription Factor Genes in Cancer - Methods are provided for identifying the presence of cancer cells in a sample by detecting hypermethylation of the promoter region of a GATA-4 transcription factor gene, a GATA-5 transcription factor gene, or both. Methods for ameliorating a cancer by effecting expression of a hypermethylation silenced GATA-4 and/or GATA-5 transcription also are provided. | 2009-04-09 |
| 20090092977 | MASS SPECTROMETRIC METHODS FOR DETECTING MUTATIONS IN A TARGET NUCLEIC ACID - Fast and highly accurate mass spectrometry-based processes for detecting particular nucleic acid molecules and mutations in the molecules are provided. | 2009-04-09 |
| 20090092978 | ASSOCIATION OF UQCRC1SNPs WITH FAT DEPOSITION AND FATTY ACID COMPOSITION - The present invention relates to the identification of single nucleotide polymorphisms (SNPs) in a ubiquinol-cytochrome c reductase core protein I (UQCRC1) gene and its associations association with fat deposition and fatty acid composition. The invention further encompasses methods and systems, including network-based processes, to manage the SNP data, haplotype data and other data relating to specific animals and herds of animals, veterinarian care, diagnostic and quality control data and management of livestock which, based on genotyping, have predictable meat quality traits, husbandry conditions, animal welfare, food safety information, audit of existing processes and data from field locations. | 2009-04-09 |
| 20090092979 | METHODS FOR ISOLATING LONG FRAGMENT RNA FROM FIXED SAMPLES - The present invention relates to methods for the extraction of long fragment RNA from fixed tissue specimens. In particular, the present invention relates to methods for the extraction of RNA from formalin-fixed paraffin-embedded tissue specimens for use in biologic applications, including assays based on oligonucleotide hybridization. | 2009-04-09 |
| 20090092980 | miRNA PROCESSING INHIBITOR EFFICACY ASSAYS AND SUBSTANCES - The invention relates to assays for assessing miRNA maturation effector (preferably: inhibitor) efficacy, and to substances useful for influencing, particularly for inhibiting, maturation of miRNA. According to the invention there is provided assay of miRNA processing inhibitor efficacy, comprising the steps of: a) providing a target miRNA precursor, b) providing a potential inhibitor of one or more processing steps of the target miRNA precursor, c) bringing together of the target miRNA precursor and the potential inhibitor under miRNA maturation conditions, and d) determining inhibition efficiency. The assay of the present invention allows for a very fast and easy assessment of the efficacy of a potential inhibitor in inhibiting processing of a miRNA precursor into miRNA. | 2009-04-09 |
| 20090092981 | TETRAHYDROPYRAN NUCLEIC ACID ANALOGS - The present disclosure describes tetrahydropyran nucleoside analogs, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, tetrahydropyran nucleoside analogs are provided, having one or more chiral substituents, that are useful for enhancing properties of oligomeric compounds including nuclease resistance and binding affinity. In some embodiments, the oligomeric compounds provided herein hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. | 2009-04-09 |
| 20090092982 | METHODS AND COMPOSITIONS FOR INCREASING BIOLOGICAL MOLECULE STABILITY - The present invention relates to methods and compositions for enhancing folding and stability of biological molecules. In particular, the present invention relates to methods and compositions for identifying biological molecules with enhanced stability. The present invention further relates to host cells that confer enhanced stability to biological molecules expressed therein. | 2009-04-09 |
| 20090092983 | IDENTIFICATION OF AN ERBB2 GENE EXPRESSION SIGNATURE IN BREAST CANCERS - A method for analyzing differential gene expression associated with breast tumor is based on the analysis of the over-expression or under-expression of polynucleotide sequences in a biological sample. The analysis includes the detection of the over-expression of at least one polynucleotide sequence(s), subsequence(s) or complement(s) thereof selected from predefined polynucleotide sequence sets. | 2009-04-09 |
| 20090092984 | Determining a predisposition to cancer - The present invention relates to methods and kits for determining a predisposition and surveillance protocols for developing cancer of various sites due to specific mutation in at least one allele of CHEK2 gene and/or at least one allele of NOD2 gene and/or at least one allele of CDKN2A gene. | 2009-04-09 |
| 20090092985 | Screening tools for discovery of novel anabolic agents - The disclosure provides nucleic acids including the polynucleotide sequence of the human MAFbx core promoter involved in muscle specific expression. Also provided are reporters operably linked to a polynucleotide sequence including MAFbx transcription regulatory sequences, and constructs including polynucleotides that encode reporters and other polynucleotide sequences operably linked to the MAFbx core transcription regulatory sequence. Systems for identifying agents that inhibit muscle loss and/or increase muscle mass or tone are also provided. | 2009-04-09 |
| 20090092986 | Fluorescent Nucleobase Conjugates Having Anionic Linkers - Provided are nucleotide-dye conjugates and related compounds in which a dye is linked to a nucleobase directly or indirectly by an anionic linker. The anionic character of the linker is provided by one or more anionic moieties which are present in the linker, such as phosphate, phosphonate, sulfonate, and carboxylate groups. When the dye is a provided as a donor/acceptor dye pair, the anionic linker can be located between the donor and the acceptor, or between the nucleobase and either the donor or acceptor, or both. In one embodiment, conjugates of the invention provide enhanced electrophoretic mobility characteristics to sequencing fragments, e.g., for dideoxy sequencing using labeled terminators. | 2009-04-09 |
| 20090092987 | Polymorphic Nucleic Acids Associated With Colorectal Cancer And Uses Thereof - The present invention provides compositions and methods for research, diagnostic, drug screening, and therapeutic applications related to colorectal cancer and related conditions. In particular, the present invention provides genetic variations in or associated with one or more of the STK38L, GPR45, TGFBRAP1, PADI3, IBRDC1, and/or GRK5 genes as being associated with such conditions. | 2009-04-09 |
| 20090092988 | Modulating Gene Expression with agRNA and Gapmers Targeting Antisense Transcripts - Gene expression is selectively modulated in the genome of a mammalian cell determined to be in need thereof by determining the presence of an encoded antisense transcript overlapping a promoter of the target gene; contacting the transcript with an agRNA or gapmer complementary to a portion of the transcript upstream relative to the transcription start site of the gene; and detecting a resultant modulation of expression of the target gene. | 2009-04-09 |
| 20090092989 | MICROFLUIDIC PLATFORMS FOR MULTI-TARGET DETECTION - Disclosed are example methods and devices for detecting one or more targets. An example method includes placing a sample including a first target with in a microfluidic device and hybridizing a plurality of copies of the first target with a plurality of nanostructures. The example method includes applying an electric current to the plurality of nanostructures and using an electric field created by the electric current to move the plurality of nanostructures. In addition, the plurality of nanostructures are sorted and evaluated to determine at least one of a presence, an absence, or a quantity of the first target. | 2009-04-09 |
| 20090092990 | PRIMERS AND METHODS FOR THE DETECTION AND DISCRIMINATION OF NUCLEIC ACIDS - The present invention provides novel primers and methods for the detection of specific nucleic acid sequences. The primers and methods of the invention are useful in a wide variety of molecular biology applications and are particularly useful in allele specific PCR. | 2009-04-09 |
| 20090092991 | Assays, methods and systems for predicting follicular lymphoma outcome - Assays, kits, methods and systems for predicting outcome in patients with follicular lymphoma based upon measurement of one or more phenomenologically competitive or synergistic gene pairs or a set of classifier genes are provided. | 2009-04-09 |
| 20090092992 | Novel human dickkopf-related protein and nucleic molecules and uses therefor - Novel Dkk and Dkk-related polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length Dkk and Dkk-related proteins, the invention further provides isolated fusion proteins, antigenic peptides and antibodies. The invention also provides Dkk and Dkk-related nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a Dkk and Dkk-related gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided. | 2009-04-09 |
| 20090092993 | Cellular arrays and methods of detecting and using genetic disorder markers - A method is disclosed for rapid molecular profiling of tissue or other cellular specimens by placing a donor specimen in an assigned location in a recipient array, providing copies of the array, and performing a different biological analysis of each copy. The results of the different biological analyses are compared to determine if there are correlations between the results of the different biological analyses at each assigned location. In some embodiments, the specimens may be tissue specimens from different tumors, which are subjected to multiple parallel molecular (including genetic and immunological) analyses. The results of the parallel analyses are then used to detect common molecular characteristics of the genetic disorder type, which can subsequently be used in the diagnosis or treatment of the disease. The biological characteristics of the tissue can be correlated with clinical or other information, to detect characteristics associated with the tissue, such as susceptibility or resistance to particular types of drug treatment. Other examples of suitable tissues which can be placed in the matrix include tissue from transgenic or model organisms, or cellular suspensions (such as cytological preparations or specimens of liquid malignancies or cell lines). | 2009-04-09 |
| 20090092994 | Reagents, methods and kits for classification of fungi and direction of anti-fungal therapy - Provided herein are methods, kits and compositions to classify fungi. Methods are provided for classification of fungi according to established phenotypes, for example, antimicrobial susceptibility profiles. More specifically, the invention provides methods for the use of PNA probes in diagnostic applications, which will aid in the direction of appropriate therapy against fungi. | 2009-04-09 |
| 20090092995 | Method for Identifying Within a Mammal a DNA encoding a Physiologically Active Polypeptide - The present inventors found that a physiological effect of a particular DNA can be detected independently within mice into which a pool of various DNAs in various quantities has been introduced. This finding suggests that it is possible to identify a DNA having a particular physiological effect by successively fractionating a pool of various DNAs in various quantities using the particular physiological effect seen within a mammal as an index. Such a method of screening will have the advantage of saving much time and effort as required in conventional screenings such as those utilizing transgenic and knockout mice. Furthermore, the method of screening has the additional advantage of enabling the identification of a DNA having a physiological activity, for example, even when the cells producing a physiologically active substance cannot be maintained in vitro or in immunodeficient animals, or when the cells change their characteristics during passage and stop producing the physiologically active substance. | 2009-04-09 |
| 20090092996 | MUCOPOLYSACCHARIDOSIS (MPS) DIAGNOSTIC METHODS, SYSTEMS, KITS AND ASSAYS ASSOCIATED THEREWITH - Methods, systems, kits and assays for diagnosing, monitoring or screening for mucopolysaccharidosis (MPS) and methods and systems for assaying test compounds for therapeutic activity are described, whereby MPS marker protein levels are assayed as an indication of MPS. | 2009-04-09 |
| 20090092997 | MODULATORS THAT PROMOTE CELL SURFACE EXPRESSION OF ODORANT RECEPTORS - The present invention relates to polypeptides capable of promoting odorant receptor cell surface localization and odorant receptor functional expression. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, the present invention provides methods of screening for odorant receptor accessory protein polymorphisms and mutations associated with disease states, as well as methods of screening for therapeutic agents, ligands, and modulators of such proteins. | 2009-04-09 |
| 20090092998 | MARKER FOR ARRHYTHMIA RISK - The present invention relates to markers and methods for determining risk of ventricular arrhythmia in an individual. By using the markers of the present invention, individual with high risk of ventricular arrhythmia can properly be detected and treated. The present inventors have discovered that IL-6 and/or DROMs have strongly positive correlation with the risk of ventricular arrhythmia. | 2009-04-09 |
| 20090092999 | METHODS OF PREDICTING THERAPEUTIC RESPONSE IN ATOPIC DERMATITIS TO IL-31 ANTAGONISTS - The present invention relates to predicting therapeutic response of treating patients suffering from itching and puritis mediated by cutaneous lymphocyte antigen positive T cells in atopic dermatitis. The invention also includes methods of predicting a therapeutically responsive patient population. | 2009-04-09 |
| 20090093000 | Glycoprotein and apolipoprotein biopolymer markers predictive of Alzheimers disease - The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer, predict disease risk assessment, and develop therapeutic avenues against said disease. | 2009-04-09 |
| 20090093001 | HIGH CONTENT SCREENING - A high content screening (HCS) assay for rapidly screening one or more compounds to determine functional response or pharmacological properties thereof, comprising: i) priming a cell or cell material with a sensor for a biological response; ii) contacting the compound(s) to be tested with the primed cell or cell material or contacting a cell or cell material which has been contacted with the compound(s) with the primed cell or cell material; iii) simultaneously or subsequently contacting with a fluorescent agonist or a fluorescent neutral antagonist wherein the binding of the fluorescent agonist or antagonist and its associated biological response are detected or monitored in the same cell and are distinct allowing separate readout. | 2009-04-09 |
| 20090093002 | HUMANIZED ANTIBODY - The present invention is related to chimeric and humanized antibody and to methods and compositions for the therapeutic and diagnostic use in the treatment of amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. | 2009-04-09 |
| 20090093003 | PORCINE UMAMI TASTE RECEPTORS AND USES THEREFOR - The present invention provides nucleic acids encoding porcine taste receptors, polypeptides encoded by the nucleic acids, and methods of using the nucleic acids and polypeptides to identify compounds that enhance umami taste. | 2009-04-09 |
| 20090093004 | POTENCY ASSAY - The present invention provides a method for determining the in vitro potency of antibodies, in particular anti-Rhesus D positive antibodies. Such antibodies may e.g. be used in the prophylaxis of hemolytic disease of the newborn (HDN), treatment of idiopathic thrombocytopenic purpura (ITP) and prevention of sensitization to the Rhesus D antigen after mistransfusions of RhD(+) blood to RhD(−) individuals. The invention also provides a method for monitoring the release of label from a RhD(+) red blood cell, a method for determining the ability of an antibody to induce the release of label from a RhD(+) red blood cell, and a method for determining whether a manufactured anti-RhD antibody fulfils a predefined release criterion. The invention further provides a kit for measuring the potency of an antibody. | 2009-04-09 |
| 20090093005 | PROTEIN-BASED BIOMARKERS FOR ABDOMINAL AORTIC ANEURYSM - The present invention encompasses compositions and methods useful for diagnosing subjects with abdominal aortic aneurysms. The invention relates to the use of protein biomarkers whose levels are different in subjects with abdominal aortic aneurysms relative to normal subjects. | 2009-04-09 |
| 20090093006 | Core 2 Beta(1,6)-Acetylglycosaminyltransferase as Diagnostic Marker for Atherosclerosis - A method of indicating the presence of the atherosclerosis (particularly coronary artery atherosclerosis) in a subject is provided, comprising comparing the level of Core 2 GlcNAc-T in a tissue sample from a subject with a reference level determined for the same tissue. A level of Core 2 GlcNAc-T in the tissue sample from a subject that is higher than that of the reference level being indicative that the subject is afflicted with atherosclerosis (particularly coronary artery atherosclerosis—coronary artery disease—CAD). In preferred embodiments, the sample consists of leukocytes and the protein level is determined as the enzymatic activity using radiolabeled UDP-GlcNAc and a Galβ(1,3)-GalNAc derivative. | 2009-04-09 |
| 20090093007 | METHOD FOR PRODUCING DRY ANALYTICAL ELEMENT FOR PANCREATIC LIPASE MEASUREMENT - It is an object of the present invention to provide a method for producing a dry analytical element for pancreatic lipase analysis in a stable manner with good accuracy, such element having high specificity with respect to pancreatic lipase and being available for convenient use. The present invention provides a method for producing a dry analytical element for measurement of pancreatic lipase contained in a body fluid, said element comprising at least one development layer or reagent layer containing diglyceride or triglyceride of long-chain alkyl fatty acid having 14 to 20 carbon atoms, monoglyceride lipase, and a glycerine measurement reagent which comprises a step of adding glyceride dissolved in lower alcohol or acetone to the development layer or reagent layer and drying the glyceride. | 2009-04-09 |
| 20090093008 | METHOD FOR DETECTION OF MICROORGANISM AND KIT FOR DETECTION OF MICROORGANISM - According to the following steps, live cells, injured cells, VNC cells and dead cells of a microorganism in a test sample are detected by flow cytometry: | 2009-04-09 |
| 20090093009 | MASS SPECTROMETRY METHOD FOR MEASURING THIAMINE IN BODY FLUID - Provided are methods for determining the amount of total thiamine in a body fluid sample using liquid chromatography and mass spectrometry. Total thiamine is converted to free thiamine by treatment with an acid phosphatase prior to thiamine separation and quantification. | 2009-04-09 |
| 20090093010 | Method of Detecting Kidney Dysfunction - Methods and kits for monitoring kidney function, and detecting kidney dysfunction and transplant related disease and rejection are disclosed. The method involves analyzing a sample, such as a urine sample, containing protein from an animal for fragments of β2-microglobulin, wherein the presence of specific β2-microglobulin fragments is indicative of kidney dysfunction and transplant rejection. In another embodiement, urine samples from an animal are tested for protease activity, such as cathepsin D or napsin A, wherein increased protease activity compared to a control sample is indicative of kidney dysfunction. | 2009-04-09 |
| 20090093011 | Biosensors for ligand-directed functional selectivity - A system and method for determining ligand-directed functional selectivity of a receptor in a live-cell with a biosensor are disclosed. Also disclosed is a system and method for fragment-based screening with a cell-based, label-free biosensor functional assay. | 2009-04-09 |
| 20090093012 | REACTION CASSETTE FOR MEASURING THE CONCENTRATION OF GLYCATED HEMOGLOBIN AND MEASURING METHOD THEREOF - A reaction cassette for a glycated hemoglobin meter and a measuring method thereof are provided. The reaction cassette for the glycated hemoglobin meter includes: a first zone receiving a first reagent and a blood sample; a second zone receiving a second reagent; a reaction zone in which the blood sample reacts with the first reagent, or through which the second reagent passes to react with a first blood sample mixture obtained by reacting the blood sample with the first reagent; and a measurement zone measuring an amount of total hemoglobin in the first blood sample mixture, or measuring an amount of glycated hemoglobin in a second blood sample mixture obtained by reacting the first blood sample mixture with the second reagent, wherein the blood sample, the first reagent, and the second reagent move between the reaction zone and the measurement zone according to a rotation angle of the reaction cassette when the reaction cassette is rotated. Therefore, since the reaction cassette rotates automatically, it is possible to measure the amount of glycated hemoglobin in a blood sample through simple manipulation and reduce a manufacturing time. Furthermore, since reagents are supplied to the reaction cassette from a separate reagent pack, it is possible to resolve storage and distribution problems of the reaction cassette, which occur when reagents are stored in the reaction cassette. | 2009-04-09 |
| 20090093013 | Single-Cell Label-Free Assay - The disclosure provides a system and method for characterizing a single live-cell response to a stimulus with a biosensor imaging system having cells immobilized on the biosensor at a resolution level of a single cell, as defined herein. | 2009-04-09 |
| 20090093014 | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof - This invention features a method of identifying a compound useful for enhancing efficacy of a therapeutic agent. The method includes incubating a compound in blood cells; separating immune cells from erythrocytic cells; and determining the ratio of the concentration of the compound in the immune cells to the concentration of the compound in the erythrocytic cells; wherein the compound comprises a transportophore and a therapeutic agent, in which the transportophore is covalently bonded to the therapeutic agent via a bond or a linker. | 2009-04-09 |
| 20090093015 | Beta-cryptoxanthin production using a novel lycopene beta-monocyclase gene - Novel lycopene beta-monocyclase genes were identified and used to transform a host cell to produce β-cryptoxanthin. The host cell produces lycopene and is transformed to express the novel lycopene β-monocyclase that converts lycopene into γ-carotene. The host cell is further transformed to express a lycopene hydroxylase that hydroxylates γ-carotene to 3-hydroxy-γ-carotene and a lycopene β-bicyclase that converts 3-hydroxy-γ-carotene to β-cryptoxanthin. The host cell is grown under conditions whereby γ-carotene is produced which is hydroxylated to 3-hydroxy-γ-carotene and which is converted into β-cryptoxanthin. | 2009-04-09 |
| 20090093016 | Selective Enzymatic Hydrolysis of C-Terminal Tert-Butyl Esters of Peptides - The present invention relates to a process for the selective enzymatic hydrolysis of C-terminal esters of peptide substrates in the synthesis of peptides, comprising hydrolysing C-terminal tert-butyl esters using the protease subtilisin. This process is useful in the production of protected or unprotected peptides. | 2009-04-09 |
