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14th week of 2011 patent applcation highlights part 23
Patent application numberTitlePublished
20110081592MODULAR FUEL CELL STACK ASSEMBLY INCLUDING ANODE GAS OXIDIZER AND INTEGRATED EXTERNAL MANIFOLDS FOR USE IN FUEL CELL STACK MODULES - A modular fuel cell stack assembly comprising a plurality of fuel cell stacks, each of the stacks having a plurality of stack faces and a plurality of stack corners formed between the stack faces, wherein the plurality of stack faces include a cathode inlet face adapted to receive oxidant gas for use in a cathode side of the fuel cell stack, a cathode outlet face adapted to output cathode exhaust from the cathode side, an anode inlet face adapted to receive fuel for use in an anode side of the fuel cell stack and an anode outlet face adapted to output anode exhaust from the anode side, and wherein at least one of the cathode inlet face, cathode outlet face, anode inlet face and anode outlet face is an open face without a manifold, and a containment structure for housing the plurality of fuel cell stacks and for providing fuel and oxidant gas to said fuel cell stacks, the containment structure including at least one sealed chamber for sealingly enclosing and isolating at least one open face. Also provided is a modular fuel cell assembly comprising a plurality of fuel cell stacks, an oxidizer disposed centrally of the fuel cell stacks and adapted to receive anode exhaust from the fuel cell stacks, to generate oxidant gas using the anode exhaust and to distribute the oxidant gas to the fuel cell stacks, and a containment structure for housing the plurality of fuel cell stacks and the oxidizer and adapted to receive fuel and distribute the fuel to the fuel cell stacks.2011-04-07
20110081593FUEL CELL - A fuel cell includes a stacked body formed by a plurality of single cells that are stacked together; two end plates, one of which is arranged on the outside of one end portion in the stacking direction of the plurality of single cells of the stacked body and the other of which is arranged on the outside of the other end portion in the stacking direction of the plurality of single cells of the stacked body; two fixing plates arranged on two opposing side surfaces, from among four side surfaces of the stacked body on which the end plates are not arranged, and across a gap from the stacked body; and a gas manifold arranged on at least one of the other two opposing side surfaces, from among the four side surfaces of the stacked body on which the end plates are not arranged. The gas manifold has a protruding portion that protrudes into a space formed by the gap between the fixing plates and the stacked body.2011-04-07
20110081594POLYMER MEMBRANE FOR BATTERY, METHOD OF PREPARING SAME AND BATTERY INCLUDING SAME - Disclosed is a polymer membrane for a battery including a porous support including a fiber including a core including a high melting-point polymer; and a sheath including a low melting-point polymer surrounding the core, and a method of preparing the same. The polymer membrane for a battery may further include a proton conductive polymer.2011-04-07
20110081595ELECTRODE CATALYST FOR FUEL CELL, METHOD FOR PRODUCING THE ELECTRODE CATALYST, AND POLYMER ELECTROLYTE FUEL CELL USING THE ELECTRODE CATALYST (AS AMENDED) - An electrode catalyst for a fuel cell, which has improved performance compared with conventional platinum alloy catalysts, a method for producing the electrode catalyst, and a polymer electrolyte fuel cell using the electrode catalyst are provided. The electrode catalyst for a fuel cell comprises a noble-metal-non-precious metal alloy that has a core-shell structure supported on a conductive carrier. The composition of the catalyst components of the shell is such that the amount of the noble metal is greater than or equal to the amount of the non-precious metal.2011-04-07
20110081596Novel Electrode Design for Low Temperature Direct-Hydrocarbon Solid Oxide Fuel Cells - In certain embodiments of the present disclosure, a solid oxide fuel cell is described. The solid oxide fuel cell includes a hierarchically porous cathode support having an impregnated cobaltite cathode deposited thereon, an electrolyte, and an anode support. The anode support includes hydrocarbon oxidation catalyst deposited thereon, wherein the cathode support, electrolyte, and anode support are joined together and wherein the solid oxide fuel cell operates a temperature of 600° C. or less.2011-04-07
20110081597POLYMER ELECTROLYTE, CROSSLINKED POLYMER ELECTROLYTE, POLYMER ELECTROLYTE MEMBRANE AND USE OF THE SAME - The present invention provides a polymer electrolyte, a crosslinked polymer electrolyte, a polymer electrolyte membrane and use of the same. The polymer electrolyte has a repeating unit represented by the following formula (1) in its molecule and an ion-exchange group in the molecule:2011-04-07
20110081598SOLID OXIDE ELECTROLYTE, SOLID OXIDE FUEL CELL CONTAINING THE SOLID OXIDE ELECTROLYTE, AND METHOD OF PREPARING THE SOLID OXIDE ELECTROLYTE - A solid oxide electrolyte including an oxygen ion conducting solid solution, wherein the solid solution is represented by Formula 1 below:2011-04-07
20110081599ELECTRODE CATALYST FOR FUEL CELL, METHOD OF PREPARING ELECTRODE CATALYST, AND FUEL CELL USING ELECTRODE CATALYST - Non-platinum (Pt) electrode catalysts for fuel cells, methods of manufacturing the same, and fuel cells including the non-Pt electrode catalysts. Each of the non-Pt electrode catalysts for fuel cells includes at least palladium (Pd) and iridium (Ir), and further includes a metal, oxide of the metal, or mixture thereof for compensating for the activity of Pd and Ir.2011-04-07
20110081600CARBON-TITANIUM OXIDE ELECTROCATALYST SUPPORTS FOR OXYGEN REDUCTION IN PEM FUEL CELLS - A high surface area support material is formed of an intimate mixture of carbon clusters and titanium oxide clusters. A catalytic metal, such as platinum, is deposited on the support particles and the catalyzed material used as an electrocatalyst in an electrochemical cell such as a PEM fuel cell. The composite material is prepared by thermal decomposition and oxidation of an intimate mixture of a precursor carbon polymer, a titanium alkoxide and a surfactant that serves as a molecular template for the mixed precursors.2011-04-07
20110081601Nonwoven Fabric Having Cross-Linking Material - A layer includes a main body having a plurality of first pores and at least one crosslinked binder.2011-04-07
20110081602OPTICAL DATA STORAGE MEDIA AND METHODS FOR USING THE SAME - An optical data storage medium is provided. The optical data storage medium includes a polymer matrix; a reactant capable of undergoing a change upon triplet excitation, thereby causing a refractive index change; and a non-linear sensitizer capable of absorbing actinic radiation to cause upper triplet energy transfer to said reactant. The refractive index change capacity of the medium is at least about 0.1. The reactant comprises polyvinyl chlorocinnamate, polyvinyl methoxycinnamate, or a combination thereof.2011-04-07
20110081603PELLICLE - A pellicle for lithography is provided that includes a pellicle frame, a pellicle film stretched over one end face of the pellicle frame, and a pressure-sensitive adhesion layer provided on the other end face, the pressure-sensitive adhesion layer being formed from a gel composition.2011-04-07
20110081604Pellicle for lithography and a method for making the same - There is provided a method for manufacturing a pellicle in which the pellicle frame is prepared by being heated at a predetermined temperature while constricting the frame to some extent of flatness to achieve a desired flatness and future stability against heat.2011-04-07
20110081605PHOTOMASK BLANK AND METHOD FOR MANUFACTURING THE SAME - The present invention provides a photomask blank in which a light-shielding film consisting of a plurality of layers is provided on a light transmissive substrate, wherein a layer that is provided to be closest to the front surface is made of CrO, CrON, CrN, CrOC or CrOCN, and wherein the atom number density of the front-surface portion of the light-shielding film is 9×102011-04-07
20110081606ELECTROSTATIC IMAGE DEVELOPING TONER AND IMAGE FORMING METHOD - Disclosed is an electrostatic image developing toner comprised of toner particles containing a binding resin and a coloring agent, and the coloring agent contains a black color material and a cyan color material, the content of the black color material being 0.5 to 3 parts by mass with respect to 100 parts by mass of the above binding resin, as well as the content of the cyan color material being 0.1 to 0.5 parts by mass with respect to 100 parts by mass of the above binding resin.2011-04-07
20110081607METHYLOL COMPOUND, ALDEHYDE COMPOUND, METHOD FOR PREPARING THE METHYLOL COMPOUND USING THE ALDEHYDE COMPOUND, AND PHOTORECEPTOR USING THE METHYLOL COMPOUND - A methylol compound having a specific formula such that two triphenylamine groups each having two methylol groups are connected with each other by an oxygen atom, a methylene group, a vinylene group, or an ethylene group. The methylol compound is preferably prepared by subjecting a corresponding aldehyde compound to a reduction reaction in the presence of a reducing agent. The methylol compound is preferably used as a charge transport material.2011-04-07
20110081608ELECTROPHOTOGRAPHIC TONER AND IMAGE FORMING APPARATUS - A transparent toner for electrophotographic image forming method forming an image on a recording medium with one or more chromatic toner and a transparent toner, including a thermoplastic resin; and a lubricant, wherein the transparent toner has a tangent loss (tan δ) determined by the following formula has a maximum peak value not less than 3 in a range of from 80 to 160° C.:2011-04-07
20110081609TONER - Provided is a toner including toner particles each containing a hinder resin, a colorant, and a wax, and inorganic fine particles, the toner having such a characteristic that a temperature-storage elastic modulus curve at a high frequency shows a characteristic change in its behavior in a specific temperature region with respect to a temperature-storage elastic modulus curve at a low frequency.2011-04-07
20110081610CORONA TREATMENT FOR INTERMEDIATE TRANSFER MEMBER OVERCOAT ADHESION - An intermediate transfer member substrate with an imageable seam overcoat and a process for preparing the intermediate transfer member substrate with an overcoat layer without an adhesive or primer layer is provided.2011-04-07
20110081611TONER MANUFACTURING METHOD - Disclosed is a toner manufacturing method, comprising: dispersing a polyester resin prepared by condensing a polyol and an unsaturated polycarboxylic acid into an aqueous medium and preparing a polyester resin particle dispersion liquid; adding a vinyl polymerizable monomer and a radical polymerization initiator to the polyester resin particle dispersion liquid to cause a radical polymerization reaction, followed by preparing a dispersion liquid of resin particles made of a resin in which vinyl polymerizable monomers react with the polyester resin; and mixing at least the resin particles made of the resin in which the vinyl polymerizable monomers react with the polyester resin, and a dispersion liquid of coloring agent particles, and forming toner particles by making the resin particles and the coloring agent particles cohere.2011-04-07
20110081612ACTINIC RAY-SENSITIVE OR RADIATION-SENSITIVE RESIN COMPOSITION AND METHOD OF FORMING PATTERN THEREWITH - According to one embodiment, an actinic ray-sensitive or radiation-sensitive resin composition includes (A) a resin containing the repeating units of formulae (I), (II) and (III) that when acted on by an acid, becomes soluble in an alkali developer, and (B) a compound that when irradiated with actinic rays or radiation, generates a fluorine-containing acid,2011-04-07
20110081613RADIATION-SENSITIVE RESIN COMPOSITION - An object is to provide a radiation-sensitive resin composition such that little out gas is emitted from a resin film after heat-burning even when a novolac resin is used. The present invention is directed to a radiation-sensitive resin composition containing (A) a novolac resin having repeating units with a structure in which at least a methyl group, a phenyl group, or a hydroxyphenyl group is attached in place of a hydrogen atom in a methylene group combining phenols, (B) at least one thermally-reactive compound selected from the group consisting of benzoxazine compounds, carbodiimide compounds, triazinethiol compounds, and bismaleimide compounds, and (C) a radiation-sensitive compound, and an organic electroluminescent element in which an insulating film has been formed by radiation lithography by using the composition.2011-04-07
20110081614Method of Improving Print Performance in Flexographic Printing Plates - A method of making a relief image printing element from a photosensitive printing blank is provided. A photosensitive printing blank with a laser ablatable layer disposed on at least one photocurable layer is ablated with a laser to create an in situ mask. The printing blank is then exposed to at least one source of actinic radiation through the in situ mask to selectively cross link and cure portions of the photocurable layer. Diffusion of air into the at least one photocurable layer is limited during the exposing step and preferably at least one of the type, power and incident angle of illumination of the at least one source of actinic radiation is altered during the exposure step. The resulting relief image comprises a plurality of dots and a dot shape of the plurality of dots is produced that is highly resistant to print fluting for printing on corrugated board.2011-04-07
20110081615MATERIAL FOR FORMING RESIST SENSITIZATION FILM AND PRODUCTION METHOD OF SEMICONDUCTOR DEVICE - A material for forming a resist sensitization film contains a metal salt, a resin and, a solvent. A method for producing a semiconductor device contains applying such material (or a resist) onto a processing surface so as to form a resist sensitization film or a resist film, applying a resist (or the aforementioned material) onto the resist sensitization film so as to form a resist film (or a resist sensitization film); exposing the resist film (or the resist film and the resist sensitization film) to exposure light, and developing the exposed resist film (or the exposed resist film and resist sensitization film) so as to form a resist pattern; and etching the processing surface using the resist pattern as a mask so as to pattern the processing surface.2011-04-07
20110081616PHOTOSENSITIVE RESIN COMPOSITION, PHOTOSENSITIVE ELEMENT, RESIST PATTERN MANUFACTURING METHOD, AND PRINTED CIRCUIT BOARD MANUFACTURING METHOD - A photosensitive resin composition comprising a (A) binder polymer, a (B) photopolymerizing compound having ethylenic unsaturated bonds in the molecule, a (C) photopolymerization initiator and a (D) polymerization inhibitor, wherein the (C) photopolymerization initiator comprises an acridine compound, and the content of the (D) polymerization inhibitor is 20-100 ppm by weight.2011-04-07
20110081617INTEGRATED LITHOGRAPHY EQUIPMENT AND LITHOGRAPHY PROCESS THEREOF - An integrated lithography equipment is disclosed. The equipment includes an input/output area for loading at least one wafer, a coating a developing area for performing coating and developing processes on the wafer, an exposure processing area for exposing the wafer, and an idle and transport area disposed between the coating and developing area and the exposure processing area for isothermally or adiabatically transferring wafers between the coating and developing area and the exposure processing area and holding wafers isothermally or adiabatically.2011-04-07
20110081618LITHO-LITHO ETCH (LLE) DOUBLE PATTERNING METHODS - Litho-litho-etch double patterning (LLE-DP) methods using silylation freeze technology are presented. The LLE-DP method using a silylation freeze reaction comprises providing a substrate with a first photoresist layer thereon. A first exposure process is performed defining a first latent image in a first photoresist. The first patterned structures on the substrate is developed and baked for photo-generated acid diffusion. The photo-generated acid is reacted with a silylation agent to freeze the first patterned structures. A second photoresist layer is formed overlying the substrate. A second lithography process is performed to create second patterned structures on the substrate. The first patterned structures and the second patterned structures are interlaced each other.2011-04-07
20110081619REGULATING DEVICE FOR GAS BURNERS - Regulating device for gas burners for providing a gas/air mixture, with a mixing device for mixing a gas flow with a combustion air flow and therefore for providing the gas/air mixture, wherein in a gas line which conducts the gas flow at least one gas valve is positioned, which is adjusted in dependence upon a measurement signal of an electric or electronic sensor, wherein the sensor acts on the gas line by a measuring point and wherein a reference pressure prevails on a reference point of the sensor. The mixing device may be formed as a Venturi nozzle, wherein the gas line leads to a mixing region of the Venturi nozzle in which the gas flow and the combustion air flow are mixed, wherein the reference point of the sensor acts on a device in which the reference pressure prevails, and wherein the device may be connected via a connecting line to the Venturi nozzle, that is to say to a region of the Venturi nozzle which lies downstream of the mixing region of the Venturi nozzle.2011-04-07
20110081620OXYGEN DEPLETION SENSOR - In certain embodiments, an apparatus includes an oxygen depletion sensor (ODS) includes a thermocouple, a first nozzle configured to direct heat from combustion of a first gas, liquid, or combination thereof to the thermocouple, a second nozzle configured to direct heat from combustion of a second gas, liquid, or combination thereof to the thermocouple, and a first igniter.2011-04-07
20110081621METAL BURNER MEMBRANE - The invention relates to a gas burner comprising a metal burner membrane having a base section (2011-04-07
20110081622SELF-LIGATING BRACKET WITH UNIVERSAL APPLICATION - A compact orthodontic bracket that employs a simple method of self-ligation, is compatible with both permanent and deciduous teeth and is less expensive to manufacture than existing commercial brackets. The bracket utilizes a rotary plate that covers an arch wire slot when closed and can be pivotably opened to allow arch wire changes. Ligation may also be augmented using conventional ligatures on the paired tie wings. The simplicity of the ligating mechanism allows manufacturing of a smaller bracket. It is also less vulnerable to the clogging effects of salivary deposits than commercial self-ligating brackets currently in use.2011-04-07
20110081623SELF ADJUSTING INSTRUMENT - The invention is an instrument for cleaning and/or shaping and/or widening a channel that exists in or through a solid object. The design of the instrument the superelastic and shape memory properties of the material from which it is made, allow the inner volume enclosed by the instrument, its outer contour, or both to change as a result of the forces exerted upon it while working, thereby shaping the instrument to the three-dimensional contour of the channel. A preferred embodiment of the instrument is an endodontic file for use in the cleaning, shaping, and widening stages of a root canal procedure.2011-04-07
20110081624CORDLESS DENTAL HANDPIECE, SYSTEM INCLUDING A CORDLESS DENTAL HANDPIECE, AND METHOD OF CONNECTING A CORDLESS DENTAL HANDPIECE - A cordless dental handpiece, a system including a cordless dental handpiece, and a method of connecting a cordless dental handpiece are disclosed. The cordless dental handpiece includes a first module and a second module. The second module is configured to detachably engage the first module. The second module includes a battery compartment.2011-04-07
20110081625Denture - A denture is adapted to communicate with a radio frequency identification (RFID) reader. The denture includes a denture main body and at least one RFID tag embedded in the denture main body for storage of identification information of a user of the denture. The RFID tag transmits the information to the RFID reader by radio frequency wave.2011-04-07
20110081626DENTAL IMPLANT - A dental implant is provided for supporting a dental prosthesis. The implant can comprise a body having an outer surface, a distal end, and a proximal end. The dental implant can include at least one thread located on at least a portion of the outer surface of the body. The thread can include a proximal flank and a distal flank. The thread can also include a face that extends between the proximal flank and the distal flank. Further, the dental implant can include a first helical groove formed on the face and/or a second helical groove formed on the body.2011-04-07
20110081627Methods for making provisional and long-term dental crowns and bridges - The invention provides methods of making provisional and long-term dental restorations, particularly dental veneers, crowns and bridges. In one embodiment, the restoration can be fabricated indirectly by a dental laboratory. In another version, a dental practitioner can make the restoration chairside for a patient in a dental office. A polymerizable dental composite material, which is dimensionally shape-stable in its uncured state, is used to make the restoration. A substructure such as a metal coping can be used to support the polymerizable material. The material includes a polymerizable acrylic compound, polymerization initiator system capable of being activated by light or heat, and preferably a filler material. The resulting dental restoration has good aesthetics, mechanical strength, and margins and contacts.2011-04-07
20110081628ORAL CARE COMPOSITIONS, METHODS, DEVICES AND SYSTEMS - Oral care treatments are provided, including multi-component oral care compositions and methods for delivering such compositions to the oral cavity. Oral care devices and systems for implementing such oral care treatments are also provided.2011-04-07
20110081629ORAL BRUSHING DEVICES AND/OR METHODS - An oral hygiene device having two toothbrushes connected or connectable to the end of a handle, the one or more toothbrushes providing a desirable fit about the teeth and/or gums and/or providing a desirable brushing action. An oral hygiene device hereof may provide for mechanically providing the brushing movements of the professionally recommended manual tooth-brushing method known as the “Bass” or “Modified Bass” technique to thus reduce or eliminate the element of human error associated with the brushing of a user's teeth and gums.2011-04-07
20110081630DENTAL VENEER SYSTEM AND METHOD - A system and method of manufacturing prefabricated dental veneers in a variety of sizes, shapes, and colors for a more economically feasible application of high-quality dental veneers, and a related process for selecting an appropriate veneer for a particular patient's tooth or teeth for application on the same day as the initial meeting. The system includes a storage kit which stores a variety of prefabricated veneers in different sizes, shapes, and colors. The kit can be refilled by ordering another set of prefabricated veneers when a particular set of a particular size, shape, or color is affixed to a patient's teeth. The kit also includes refining tools which allow for a degree of customization in the particular prefabricated veneer chosen for a particular patient.2011-04-07
20110081631Lifeboat Simulator - A lifeboat simulator comprises a cabin (2011-04-07
20110081632SYSTEM AND METHOD FOR DISTRIBUTED AGILE - Training system and method for distributed agile learning in a team are disclosed. In one embodiment, a system includes a simulation server, a distributed Agile learning module residing in the simulation server, and two or more client servers associated with two or more team participants. The two or more client servers are communicatively coupled to the simulation server via a network. The distributed Agile learning module selectively uses combination of numeric, alphanumeric and pictorial puzzles/brain teasers and set of role play instructions upon the team participants learning theoretical understanding of the distributed Agile practices for end to end project simulation.2011-04-07
20110081633Game for Promoting Mental Stimulation of Mentally Impaired Individuals - The present invention provides games for promoting mental stimulation of individuals. In one aspect, the game includes random selection of activities to be performed by an individual for causing mental stimulation of the individual. The random activities are particularly designed to cause mental stimulation of individuals having impaired mental faculties. In one embodiment, the present invention provides a game. The game includes a first, second and third set of cards each set having a first indicia and instructions directing a user to perform an activity related to a category of the card set, wherein the categories of each card set are different. The game further includes a die having multiple surfaces, wherein the die includes at least one surface having the first indicia, at least one surface having the second indicia and at least one surface having the third indicia.2011-04-07
20110081634Behaviour Pattern Analysis System, Mobile Terminal, Behaviour Pattern Analysis Method, and Program - Provided is a mobile terminal including a movement sensor that detects a movement of a user and outputs movement information, acquires information on a building existing at a current location or information on buildings existing in a vicinity of the current location, analyses the movement information output from the movement sensor, and detects a first behaviour pattern corresponding to the movement information from multiple first behaviour patterns obtained by classifying behaviours performed by the user over a relatively short period of time, and analyses the information on a building or buildings and the first behaviour pattern, and detects a second behaviour pattern corresponding to the information on a building or buildings and the first behaviour pattern from multiple second behaviour patterns obtained by classifying behaviours performed by the user over a relatively long period of time.2011-04-07
20110081635BIBLE READING BOOKMARK AND METHOD OF USING THE SAME - The bible reading bookmark is a bookmark forming a substantially planar main body having opposed front and rear faces. Each of the front and rear faces is divided into a plurality of regions, with each region representing a distinct biblical passage. Front and rear sets of indicia are formed on the front and rear faces, respectively, of the substantially planar main body, the front and rear sets of indicia defining and separating the plurality of regions. Each of the regions includes indicia forming a checkbox, a name of a book of the bible, and a range of verses. In use, the user places the bookmark between adjacent pages of a bible corresponding to a selected bible passage. The user reads the selected bible passage and then forms a mark in the checkbox of the region corresponding to the selected bible passage upon completion of the selected bible passage.2011-04-07
20110081636Dual gender cancer teaching kit - This product is a dual gender teaching kit (The Kit) for breast and testicular cancer examination, comprising of a soft silicone material with artificial cancerous nodules and an accompanying compact disk containing automated examination instructions. The female cancer sample will contain multiple sized acrylic nodules embedded within the silicone body. The male cancer sample will contain an acrylic testicle with an abscessed deformity as well as a small sized acrylic nodule. The silicone samples will be attached to a base and packaged within a heavyweight paper sleeve which will also house an instructional compact disk for both the breast and testicular self-examination.2011-04-07
20110081637Electron Configuration Teaching Systems and Methods - A computerized method and system for demonstrating and teaching electron configurations in atomic structure are disclosed. One method includes presenting to a user one or more user interfaces stored in memory of the computing system, the one or more user interfaces includes a plurality of electron configuration diagrams. The method also includes receiving user input into an orbital box diagram displayed in the one or more user interfaces, the user input defining a possible electron configuration. The method further includes in response to the user input, updating the one or more user interfaces to illustrate the electron configuration received from the user, and if instructed by the user, generates a report regarding the compliance of the user-entered electron configuration with one or more electron configuration rules.2011-04-07
20110081638Learning method for chemical compound nomenclature - An entertaining and educational apparatus is provided, comprising a first board and a second board. The first board, that is for beginners and intermediates has a plurality of colored spaces, each color stands for a concept in IUPAC nomenclature system. The second board that is for intermediates and advanced levels has 289 square spaces of equal dimensions, some spaces contain premium score.2011-04-07
20110081639Daisy Oracle of Love - An artificial daisy flower with the petals 2011-04-07
20110081640Systems and Methods for Protecting Websites from Automated Processes Using Visually-Based Children's Cognitive Tests - Visually based children's cognitive tests can be used as a human challenge or Turing test to verify that a human and not an automated process is operating a particular system, such as purchasing tickets, downloading files, accessing a database, or requesting a reprieve from an anti-spam system. Several different visually oriented cognitive tests can be used as a human challenge, for example, selecting one object in a group of object that is different, selecting an object from a group of objects which is most similar to a given object, selecting two objects in a group of objects that are most similar, finding a given object in a scene, counting the number of instances of an object in a scheme and object based analogies.2011-04-07
20110081641Method and Apparatus for Automating Chemical and Biological Assays - A device which collects specimen fluids or performs chemical or biological assays of the specimen fluid is provided with a specimen fluid receiver and a fluid actuated trigger coupled to receive specimen fluid from the specimen fluid receiver. The trigger is made of a material which expands substantially upon absorbing specimen fluid, and it is mounted and positioned so as to contact and move another component of the device upon expanding through the absorption of specimen fluid. Preferably, the trigger is mounted to the other component and is positioned to press against a stationary surface upon expanding, so that the trigger causes the other component to move. Also, the other component may contain a surface coupled to receive specimen fluid from the specimen fluid receiver and the surface has an area which contains a substance which interacts with the specimen fluid. The trigger is coupled to receive specimen fluid from the specimen fluid receiver in such a manner that there is a predetermined delay before the trigger expands sufficiently to move the other component, and the specimen fluid interacts with the substance during delay.2011-04-07
20110081642Selection of B Cells with Specificity of Interest: Method of Preparation and Use - The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides methods using a composition comprising an ordered and repetitive antigen or antigenic determinant array for visualization and selection of B cells specific for the antigen. These B cells are useful for the production of monoclonal antibodies used for therapy, diagnostic or research purposes.2011-04-07
20110081643Flow Focusing Method and System for Forming Concentrated Volumes of Microbeads, and Microbeads Formed Further Thereto - In a method and system for forming concentrated volumes of microbeads, a polymer solution and/or suspension includes a polymer dissolved and/or dispersed in a medium. Streams of a focusing fluid and of the polymer solution and/or suspension flow towards a fluid bath, and into intersection with one another, so &s to focus the polymer solution and/or suspension. The polymer solution and/or suspension stream forms microbeads in the fluid bath. Some of the focusing fluid is drawn from the fluid bath, so as to concentrate the microbeads in die fluid bath. The system includes a flow focusing apparatus and a liquid-containing cell. The focusing apparatus includes polymer and focusing nozzles. The cell contains the fluid bath and has an outlet port, through which the focusing fluid is drawn from the fluid bath.2011-04-07
20110081644CELL LINE STABLY EXPRESSING MUTATED ONCOPROTEIN E6 AND METHOD OF SCREENING ANTICANCER COMPOUND OF UTERINE CERVICAL CANCER USING THE SAME - Disclosed are a cell line that expresses protein of Seq. No. 1, and a method for screening an anticancer compound of uterine cervical cancer by using the same. The stable cell line that expresses oncoprotein E6 of a human papillomavirus type 16 variant strain is used to determine a difference in amounts of expression of tumor suppressor genes, such as p53, between E6 protein of the reference strain and E6 protein of a variant strain, thereby screening an anticancer compound of uterine cervical cancer, etc. Further, it is possible to develop an anticancer agent of uterine cervical cancer.2011-04-07
20110081645COMPOSITIONS AND METHODS FOR DETECTING HEPATITIS B VIRUS - Compositions, methods and kits for detecting viral nucleic acids. Targets that can be detected in accordance with the invention include HBV and/or HIV-1 and/or HCV nucleic acids. Particularly described are oligonucleotides that are useful as hybridization probes and amplification primers that facilitate detection of very low levels of HBV nucleic acids.2011-04-07
20110081646DENGUE VIRUS ASSAY - Nucleic acid assays for detecting nucleic acids of Dengue virus serotypes 1-4.2011-04-07
20110081647NUCLEOTIDE ANALOGS - The invention generally relates to nucleotide analogs and methods of their use in sequencing-by-synthesis reactions. In certain embodiments, the invention provides a nucleotide analog including a detectable label attached to a nitrogenous base portion of a nucleotide analog by a cleavable linker, in which contact of the analog with at least one activating agent results in cleavage of the label and elimination of the linker, thereby producing a natural nucleotide, a 9-deaza-G, 9-deaza-A, or ψ-uridine.2011-04-07
20110081648Methods for diagnosing peripheral neuropathy - Genes whose expression is correlated with the presence of CIDP or vasculitic neuropathy are disclosed. Probes and sets of nucleic acids and proteins specific for these genes are described, as are molecular and immunological methods for aiding in the diagnosis of these disease conditions in a subject.2011-04-07
20110081649DIAGNOSIS, STAGING AND MONITORING OF INFLAMMATORY BOWEL DISEASE - A method of differentiating between active and inactive IBD in a gastrointestinal mucosa sample or a sample from a sentinel lymph node draining gastrointestinal mucosa comprises preparing a suspension of single cells from the sample, analyzing the suspension for expression of the inflammation activation marker CD69 on CD4+ T helper cells using directly labelled fluorescent DC69 antibody; comparing the number of T helper cells expressing DC69 in the sample with that obtained from a corresponding sample of a healthy person, a significantly increased level of T helper cells expressing CDD69 signifying the presence of active IBD and a less than significantly increased level of T helper cells signifying the presence of inactive IBD. Also disclosed are methods of differentiating between ulcerative colitis (UC) and Crohn's disease (CD), of detecting UC and CD, and of determining the susceptibility of an IBD patient to steroid treatment.2011-04-07
20110081650FREE NGAL AS A BIOMARKER FOR CANCER - Uncomplexed neutrophil gelatinase associated lipocalin (NGAL) is present at increased levels in individuals with atypical ductal hyperplasia (ADH), a major risk factor for future breast cancer development; in individuals that have ovarian cancer; and in individuals that have breast cancer, both invasive and noninvasive. Accordingly, the present invention is directed to measuring uncomplexed NGAL levels in urine as a primary screen to determine if an individual is either at risk of developing, or has developed cancer, e.g., cancer of epithelial origin including breast and ovarian cancer.2011-04-07
20110081651EGFR AND KRAS MUTATIONS - The present invention relates to mutations in Epidermal Growth Factor Receptor (EGFR) and KRAS and methods of detecting such mutations as well as prognostic methods for identifying tumors that are susceptible to anticancer therapy such as chemotherapy and/or kinase inhibitor treatment. The methods involve determining the presence of a mutated EGFR gene or mutated EGFR protein and/or a mutated KRAS gene or mutated KRAS protein in a tumor sample.2011-04-07
20110081652METHOD OF CLASSIFYING GENE EXPRESSION STRENGTH IN LUNG CANCER TISSUES - The present invention provides a method of confirming the gene expression, useful in the decision of a five year survival rate of a patient with lung cancer and the use of a DNA probe kit in the method. A method useful in the decision of a survival rate of a patient with non-small cell lung cancer comprising confirming the expression strength of at least one gene in lung cancer tissues isolated from the patient.2011-04-07
20110081653High Spatial Resolution Imaging of a Structure of Interest in a Specimen - In high spatial resolution imaging, a structure in a specimen is marked with a substance which, in a first electronic state, is excited by light of one wavelength to emit fluorescent light, which is also converted from its first into a second electronic state by that light, and which returns from its second into its first electronic state. The specimen is imaged onto a sensor at a spatial resolution not resolving an average spacing between neighboring molecules of the substance, and exposed to the light at such an intensity that the molecules in the first state are alternately excited to emit fluorescent light and converted into their second state, and that at least 10% of the molecules presently in their first state lie at a distance from their closest neighboring molecules in their first state which is greater than the spatial resolution of the imaging onto the sensor.2011-04-07
20110081654TRANSCRIPTIONAL PROFILING OF STEM CELLS AND THEIR MULTILINEAGE DIFFERENTIATION - The present invention concerns methods of screening cells for differentiation or de-differentiation, and/or for status as a pluripotent or multipotent (e.g., “stem”) cell, by detecting the differential expression (e.g., upregulation, downregulation) of genes.2011-04-07
20110081655NUCLEIC ACID ANALYZING DEVICE AND NUCLEIC ACID ANALYZER - An object of the present invention relates to distinguishing, from a fluorophore of an unreacted substrate, a single fluorophore attached to a nucleotide that is incorporated into a probe by a nucleic acid synthesis. The present invention relates to a nucleic acid analyzing device that analyzes a nucleic acid in sample by fluorescence, wherein a localized surface plasmon is generated by illumination, and a probe for analyzing the nucleic acid in the sample is on the site where the surface plasmon is generated. According to the present invention, since it is possible to efficiently produce fluorescence intensifying effects due to the surface plasmon and to immobilize the probe to a region within the reach of the fluorescence intensifying effects, it becomes possible to measure a nucleic acid synthesis without removing unreacted nucleotide to which fluorophores are attached.2011-04-07
20110081656Secreted proteins and uses thereof - The invention provides isolated nucleic acid molecules, designated TANGO 228 nucleic acid molecules, which encode secreted proteins with homology to the rat MCA-32 protein, isolated nucleic acid molecules, designated TANGO 240 nucleic acid molecules, which encode secreted proteins with homology to the 2011-04-07
20110081657CONTROLLED PLATELET ACTIVATION TO MONITOR THERAPY OF ADP ANTAGONISTS - A method is provided of determining whether an individual has reduced ability to form platelet thrombi due to inhibition of platelet activation initiation, signal transduction and/or GPIIb/IIIa blockade. A blood sample is obtained from the individual being assessed. The blood sample is mixed in combination with 1) an anticoagulant; 2) sufficient buffer to maintain the pH and salt concentration of the anticoagulated blood within a range suitable for platelet aggregation; 3) a platelet GPIIb/IIIa receptor ligand immobilized on a solid surface; 4) one or more agents to enhance a signal transduction pathway and 5) a receptor activator. The combination is incubated under conditions for agglutinating particles. Platelet-mediated agglutination is assessed in the agitated mixture. The absence of agglutination indicates that the individual has a reduced ability to form platelet thrombi.2011-04-07
20110081658T1R3 BINDING ASSAYS - Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.2011-04-07
20110081659SUBSTRATES FOR GLYCOGEN SYNTHASE KINASE 3 ENZYMES AND METHODS OF USE - Methods and compositions for glycogen synthase kinase 3 assays continue to be required for detection of glycogen synthase 3 kinase, assessment of glycogen synthase 3 kinase activity and identification of modulators of glycogen synthase 3 kinase. Methods and compositions for glycogen synthase kinase 3 assays are provided herein based on the discovery of a previously unknown interaction between glycogen synthase 3 kinase and eukaryotic translation initiation factor 4E-binding protein 1 which serves as a substrate for glycogen synthase kinase 3-alpha and glycogen synthase kinase 3-beta.2011-04-07
20110081660Method for Detecting Misfolded Proteins and Prions - The invention provides methods and kits for detecting conformationally altered proteins, such as prions or other proteins associated with disease states, in a sample. The methods comprise selectively capturing and separating complexes of peptide and conformationally altered protein from substances that interfere with detection of such complexes, and preferably amplification of the detection signal b addition of a second double-labeled peptide.2011-04-07
20110081661Modified photoproteins with increased affinity for calcium and enhanced bioluminescence and uses thereof - The present invention provides modified photoproteins, e.g., modified Clytin, having an increased affinity for calcium as well as an enhanced bioluminescence and their use as calcium indicators in reporter gene systems and in cell-based assays.2011-04-07
20110081662SCREENING METHODS FOR BONE MORPHOGENETIC MIMETICS - Disclosed are methods for identifying agents which modulate the activity of bone morphogenetic protein-7. These methods for identifying agents utilize bone morphogenetic protein receptors, specifically the daf-4 receptor, and more specifically the extracellular domain of the daf-4 receptor. Agents identified by the methods are also described as well as compositions comprising the agents and methods of treating a subject using the agents or compositions.2011-04-07
20110081663Molecular Probe for Imaging of Pancreatic Islets and Use of the Same - A molecular probe for imaging of pancreatic islets is provided. The molecular probe includes a polypeptide represented by the following formula (1), or a polypeptide that has a homology with the foregoing polypeptide.2011-04-07
20110081664MULTIPURPOSE MICROFLUIDIC DEVICE FOR MIMICKING A MICROENVIRONMENT WITHIN A TUMOR - The present application relates generally to a novel microfluidic device for the in it propagation of neoplastic cellagregates under conditions that mimic the physiological microenvironment found in tumors. The invention also describes methods of screening for therapeutic test agents and protocols that target proliferating and quiescent neoplastic cells within tumors.2011-04-07
20110081665Methods for making cancer prognoses based on subcellular localization of biomarkers - This invention provides a method of making a prognosis for a patient afflicted with a type of cancer such as colon cancer, based upon quantification of biomarkers such as thymidylate synthase in subcellular compartments.2011-04-07
20110081666ANTI-PSGL-1 INHIBITORS AND SCREENING METHODS - The present invention is directed to antibodies and binding fragments thereof, which bind with high affinity and specificity to human P-selectin glycoprotein ligand 1 (PSGL-1) and which block both selectin and chemokine binding to PSGL-1 expressed on leukocytes, lymphocytes and endothelial cells and thus which inhibit migration and/or rolling of these cells and to methods for screening for inhibitory compounds including such antibodies and binding fragments thereof and to methods of therapeutic use thereof.2011-04-07
20110081667BIOMARKERS ASSOCIATED WITH NEPHROPATHY - Use of urine biomarkers for diagnosing nephropathy, monitoring nephropathy progress, and assessing efficacy of a nephropathy treatment. These urine biomarkers include leukocyte-associated Ig-like receptor-2, alpha-1 acid glycoprotein, their fragments, and combinations thereof.2011-04-07
20110081668BIOMARKERS ASSOCIATED WITH NEPHROPATHY - Use of urine biomarkers for diagnosing nephropathy, monitoring nephropathy progress, and assessing efficacy of a nephropathy treatment. These urine biomarkers include leukocyte-associated Ig-like receptor-2, alpha-1 acid glycoprotein, their fragments, and combinations thereof.2011-04-07
20110081669SYSTEMS AND METHODS FOR DIAGNOSIS AND PROGNOSIS OF CANCER - Methods for diagnosing a cancer in a subject are provided that include determining an amount of autoantibodies immunoreactive to procathepsin D (pCD) in a sample obtained from the subject. Further provided are systems for diagnosing a cancer in a subject that include an autoantibody immunoreactive pCD antigen and a means for detecting binding of an autoantibody to the antigen.2011-04-07
20110081670LUCIFERASE-BASED ASSAYS - A method and kit are provided for enhancing the tolerance of an assay reagent to compounds in an assay sample, the assay reagent including a luciferase enzyme. The method includes contacting the luciferase with a tolerance enhancement agent in an amount sufficient to substantially protect luciferase enzyme activity from interference of the compound and minimize interference by at least about 10% relative to an assay not having tolerance enhancement agent.2011-04-07
20110081671VASCULAR MARKERS IN THE REMODELING OF CARDIAC INJURY - The present invention is concerned with diagnostic means and methods. More specifically, the present invention relates to a method for diagnosing the angiogenic status of a subject suffering from myocardial infarction comprising determining the amounts of P1GF, sFLT1 and endoglin in a first sample of a subject obtained after myocardial infarction and in a second sample of the subject obtained after the first sample and comparing the amounts in the first sample with those in the second sample whereby the angiogenic status is diagnosed. The present invention also encompasses a method of determining whether a subject suffering from myocardial infarction is susceptible to a pro-angiogenic therapy. Finally, the present invention relates to a kit or a device for carrying out the method of the invention.2011-04-07
20110081672PROCESS CONTROL OF BIOTECHNOLOGICAL PROCESSES - A biotechnological process for conversion of a raw material (2011-04-07
20110081673Diagnostic Gum for Screening Diabetes - A diagnostic chewing gum for identifying a risk for diabetes includes a mixture of an enzyme, a conjugated protein of the glucose enzyme, a substrate, and a gum base. The enzyme and the conjugated protein facilitate a conversion of the substrate to produce a detectable signal in the presence of glucose to produce a detectable change in the gum. In use, the gum is chewed, the resulting change in the gum is compared against a chart, and the risk for diabetes is determined from the chart.2011-04-07
20110081674CONTINUOUS-FLOW DEFORMABILITY-BASED CELL SEPARATION - This invention provides methods utilizing a microfluidic device that can quickly and accurately discern differences in deformability between individual cells and sets of cells and continuously fractionate populations of cells based on their deformability. This information may be important in disease diagnosis and treatment efficacy monitoring. For example such a device may be able to determine the stage of malarial infection by using red blood cell deformability. Additionally, methods of the invention may be used as a tool to screen drugs that can make cells more flexible in diseases such as sickle cell anemia that causes sickle cell crises. The relatively low manufacturing and operation costs of methods of the invention enable this device to be used in resource-limited settings to diagnose and monitor disease.2011-04-07
20110081675Metabolic Biomarkers Of Drug-Induced Cardiotoxicity - The invention provides methods and biomarkers for assessing cardiac metabolic response to pharmaceuticals, environmental agents, chemical compounds and biologic therapies. The invention provides methods for identifying cellular metabolites secreted by primary cardiomyocytes, cardiomyocyte precursor cells, clonal cardiomyocytes derived from adult human heart, immortalized cardiomyocytes, human embryonic stem cell (hESC)-derived cardiomyocytes, human induced pluripotent stem cell (iPS)-derived cardiomyocytes, or any cell displaying cardiomyocyte-specific markers in response to exposure to pharmaceuticals, environmental agents, chemical compounds and biologic therapies that are cardiotoxic. Cardiomyocyte-secreted cellular metabolites provide metabolic signatures of cardiotoxicity, and can be used to screen pharmaceutical agents, lead and candidate drug compounds, biologics, and other therapeutics for cardiotoxic effects.2011-04-07
20110081676RAPID DETECTION OF VIABLE BACTERIA SYSTEM AND METHOD - An improved system and method is provided for detecting viable bacteria in a suspension sample. A sample of a suspension in which bacterial presence is suspected is collected from a source and a portion of the sample transferred to a microfluidic unit. A series of analysis signals at different frequencies are applied to the sample portion. An impedance is measured via a signal analyzer for the sample portion for each of the analysis signals to define an impedance data set. An initial bulk capacitance value is determined for a model circuit based on the impedance dataset. After a predetermined time period, a new bulk capacitance value is determined for on another portion of the sample. The difference between the new bulk capacitance and the initial bulk capacitance value is compared to a threshold value to determine if viable bacterial is present in the sample.2011-04-07
20110081677Active Microfluidic Membranes - The present invention relates to a biofabricated Active Microfluidic Membrane (AMM) in a microfluidic network of a microfluidic device and a method for the in situ biofabrication of such a microfluidic network. More specifically, the invention relates to devices exhibiting (and methods of) positioning (i.e., erecting, modifying or removing a membrane matrix in situ in a microchannel of a microfluidic network of a microfluidic device. In one embodiment, the membrane comprises a single type of matrix constituent, such as chitosan, alginate, etc. Alternatively, the membrane may be composed of two or more matrix constituents, which may be integrated into one another or layered adjacent to one another.2011-04-07
20110081678METHOD FOR PRODUCING BETA-ALANYL-AMINO ACID OR DERIVATIVE THEREOF - The present invention provides a method for efficiently producing a β-alanyl-amino acid (e.g., carnosine) or derivative thereof. Specifically, it provides a method for producing a β-alanyl-amino acid (e.g., β-alanyl-histidine) or derivative thereof, by reacting a β-alanyl ester or a β-alanyl amide and an amino acid or derivative thereof in the presence of an enzyme or an enzyme-containing product that has an ability to form the β-alanyl-amino acid (e.g., β-alanyl-histidine) or derivative thereof from the β-alanyl ester or the β-alanyl amide and the amino acid (e.g., histidine) or derivative thereof. The present invention also provides a protein which is able to catalyze production of a β-alanyl-amino acid or derivative thereof from a β-alanyl ester or a β-alanyl amide and an amino acid or derivative thereof, and a polynucleotide encoding said protein.2011-04-07
20110081679MAMMALIAN CELL CULTURE PROCESSES FOR PROTEIN PRODUCTION - The present invention describes methods and processes for the production of proteins, particularly glycoproteins, by animal cell or mammalian cell culture, preferably, but not limited to, fed-batch cell cultures. In one aspect, the methods comprise the addition of glucocorticoid compound during the culturing period. The addition of glucocorticoid compound sustain a high viability of the cultured cells, and can yield an increased end titer of protein product, and a high quality of protein product, as determined, e.g., by sialic acid content of the produced protein.2011-04-07
20110081680Animal Protein-Free Media For Cultivation of Cells - The present invention relates to animal protein-free cell culture media comprising polyamines and a plant- and/or yeast-derived hydrolysate. The invention also relates to animal protein-free culturing processes, wherein cells can be cultivated, propagated and passaged without adding supplementary animal proteins in the culture medium. These processes are useful in cultivating cells, such as recombinant cells or cells infected with a virus, and for producing biological products by cell culture processes.2011-04-07
20110081681HUMAN ANTIBODIES TO HUMAN CD20 AND METHOD OF USING THEREOF - A human antibody or antigen-binding fragment of an antibody that specifically binds human CD20 and is capable of inducing complement dependent cytotoxicity (CDC), and is capable of increasing symptom free survival time between about 2-fold to about 9-fold or more, relative to control-treated animals in a mouse model of human lymphoma. The antibody or antigen-binding fragment thereof is useful in a therapeutic method for treating a CD20-mediated disease or condition, such as for example, non-Hodgkin's lymphoma, rheumatoid arthritis, systemic lupus erythematosus, Crohn's disease, chronic lymphocytic leukemia, and inflammatory diseases.2011-04-07
20110081682PRODUCTION OF BONE MORPHOGENIC PROTEINS (BMPS) USING A NOVEL TISSUE CULTURE PLATFORM - The present disclosure provides methods for producing Bone Morphogenetic Proteins (BMPs). The BMPs are produced using ex vivo-derived mineralized three-dimensional bone constructs of varying degrees of maturity and mineralization. The bone constructs are obtained by culturing osteoblasts and osteoclast precursors under randomized gravity vector conditions whereupon the bone constructs secrete BMPs into the culture medium. Culture medium is periodically removed from the bone construct culture, and the BMPs are purified from the removed culture medium.2011-04-07
20110081683Methods of combined bioprocessing and related microorganisms, thermophilic and/or acidophilic enzymes, and nucleic acids encoding said enzymes - A genetically modified organism comprising: at least one nucleic acid sequence and/or at least one recombinant nucleic acid isolated from 2011-04-07
20110081684METHOD FOR CARRYING OUT AN ENZYMATIC REACTION - The invention relates to a method for carrying out an enzymatic reaction, in particular for carrying out a polymerase chain reaction (PCR). Said method consists of the following steps: at least one eukaryotic cell is removed from a starting material; the cell core or cores of the eukaryotic cell(s) is/are coloured; at least one eukaryotic cell is deposited on a reaction point of a solid substrate in a liquid volume of less than 10 μl; it is detected whether at least one coloured cell core is present on a reaction point of the substrate, subsequently, an enzyme and optionally a reaction buffer is added to the eukaryotic cell(s) and the enzymatic reaction is subsequently started. Preferably, the claimed invention is carried out using a flow cytometer.2011-04-07
20110081685COMPOSITIONS AND METHODS FOR PROCESSING AND AMPLIFICATION OF DNA, INCLUDING USING MULTIPLE ENZYMES IN A SINGLE REACTION - The present invention concerns preparation of DNA molecules, such as a library, using a stem-loop oligonucleotide. In particular embodiments, the invention employs a single reaction mixture and conditions. In particular, at least part of the inverted palindrome is removed during the preparation of the molecules to facilitate amplification of the molecules. Thus, in specific embodiments, the DNA molecules are suitable for amplification and are not hindered by the presence of the palindrome.2011-04-07
20110081686Reactor for Bulk Manufacture of PCR Amplicons - A reactor and methods of use are disclosed for amplification of an amplicon. The reactor includes a housing having a fluid path with a fluid inlet and a fluid outlet and one or more reaction chambers suitable for housing the amplicon. The reaction chambers are positioned within the housing in thermal communication with a fluid flowing in the fluid path to heat and/or cool the reaction chambers and the inside of the reaction chambers are coated with or are a plastic material. A variable temperature fluid source is in fluid communication with the fluid inlet and the fluid source is configured to provide fluid at temperatures suitable for amplification, including a denature temperature, an anneal temperature, and an extension temperature. A controller is coupled to the variable temperature fluid source to control a fluid temperature within the fluid path by controlling the variable temperature fluid source.2011-04-07
20110081687Enrichment Through Heteroduplexed Molecules - The present invention relates to the enrichment of specific target sequences. Enrichment can be achieved through the formation of a heteroduplex that includes the specific target sequence and then the specific cleavage of the heteroduplex. A binding moiety is then added to the cleaved heteroduplex, allowing for the subsequent manipulation of the specific target sequence in the heteroduplex.2011-04-07
20110081688Water-Soluble Rhodamine Dyes Conjugates - The present invention provides novel, water-soluble, red-emitting fluorescent rhodamine dyes and red-emitting fluorescent energy-transfer dye pairs, as well as labeled conjugates comprising the same and methods for their use. The dyes, energy-transfer dye pairs and labeled conjugates are useful in a variety of aqueous-based applications, particularly in assays involving staining of cells, protein binding, and/or analysis of nucleic acids, such as hybridization assays and nucleic acid sequencing.2011-04-07
20110081689Process for Thermal-Mechanical Pretreatment of Biomass - Disclosed is a process for the thermal-mechanical pretreatment of biomass. The process includes subjecting a biomass feedstock including fibers containing cellulose, hemicellulose and lignin, to thermal reaction under conditions exceeding atmospheric pressure, at a temperature exceeding ambient temperature, at a predetermined moisture content and for a predetermined amount of time. Subsequently, the pressure of said thermal reaction is reduced under conditions resulting in explosive decompression of said biomass. The decompressed biomass is then subjected to axial shear forces to mechanically reduce the size of the fibers of the biomass to obtain treated biomass. The resultant treated biomass has a high level of enzymatic digestability and a low concentration of degradation products.2011-04-07
20110081690Sustainable method for synthesizing tetrodotoxin (TTX) - A sustainable biosynthesizing of tetrodotoxin (TTX) based on seed culture of 2011-04-07
20110081691GENE THAT INCREASES PRODUCTION OF PLANT FAT-AND-OIL AND METHOD FOR USING THE SAME - This invention is intended to search for a transcription regulator having a novel function of improving the amount of substances produced per individual plant and to enhance such properties in a plant. A chimeric protein resulting from the fusion of a transcription factor belonging a transcription factor family that includes a transcription factor comprising the amino acid sequence as shown in SEQ ID NO: 4 with the repressor domain is expressed in a plant.2011-04-07
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