| 14th week of 2012 patent applcation highlights part 34 |
| Patent application number | Title | Published |
|---|
| 20120082942 | METHOD AND SYSTEM FOR MODIFYING PHOTORESIST USING ELECTROMAGNETIC RADIATION AND ION IMPLANTATION - A method of reducing surface roughness of a resist feature disposed on a substrate includes generating a plasma having a plasma sheath and ions therein. A shape of the boundary between the plasma and plasma sheath is modified using a plasma sheath modifier, so that a portion of the boundary facing the substrate is not parallel to a plane defined by the substrate. During a first exposure, the resist feature is exposed to electromagnetic radiation having a desired wavelength and the ions are accelerated across the boundary having the modified shape toward the resist features over an angular range. | 2012-04-05 |
| 20120082943 | DIFFRACTIVE PHOTO MASKS AND METHODS OF USING AND FABRICATING THE SAME - An exemplary embodiment of the present invention provides a diffractive photo-mask comprising a body element, a plurality of interference/image-forming hologram gratings, and a zero-order beam blocking element. The plurality of interference/image-forming hologram gratings can be located on or in the body element. The plurality of interference/image-forming hologram gratings are configured to diffract a light beam to produce one or more functional elements surrounded by a high-spatial-frequency periodic optical-intensity distribution at a substrate plane when the light beam is incident upon the diffractive photo-mask. The zero-order beam blocking element is configured to block zero-order diffracted beams when the light beam is incident upon the diffractive photo-mask | 2012-04-05 |
| 20120082944 | Patterning nano-scale patterns on a film comprising unzipping copolymers - The invention concerns a method for patterning a surface of a material. A substrate having a polymer film thereon is provided. The polymer is a selectively reactive polymer (e.g., thermodynamically unstable): it is able to unzip upon suitable stimulation. A probe is used to create patterns on the film. During the patterning, the film is locally stimulated for unzipping polymer chains. Hence, a basic idea is to provide a stimulus to the polymeric material, which in turn spontaneously decomposes e.g., into volatile constituents. For example, the film is thermally stimulated in order to break a single bond in a polymer chain, which is sufficient to trigger the decomposition of the entire polymer chain. | 2012-04-05 |
| 20120082945 | METHOD FOR USING A TOPCOAT COMPOSITION - A method of forming an image on a photoresist. The method includes: forming a photoresist over a substrate; applying a topcoat composition, the topcoat composition comprising at least one fluorine-containing polymer and a casting solvent, onto the photoresist; removing the casting solvent of the topcoat composition resulting in the formation of a topcoat material over the photoresist; exposing the photoresist to radiation, the radiation changing a chemical composition of the regions of the photoresist exposed to the radiation, forming exposed and unexposed regions in the photoresist; and removing i) the topcoat material and ii) the exposed regions of the photoresist or the unexposed regions of the photoresist. | 2012-04-05 |
| 20120082946 | METHOD FOR CARRYING OUT COMBUSTION IN AN INDUSTRIAL FURNACE - A method for combustion in an industrial furnace having fuel and a first oxidizer to heat a material includes arranging at least one lance in a sidewall of the furnace; supplying a second oxidizer with an oxygen content of at least 85 percent by weight in the form of a jet traveling at at least sonic velocity to the interior of the furnace through the at least one lance; running the jet of the second oxidizer in the horizontal plane above the material between and essentially in parallel with two consecutive rows of the roof burners; balancing an amount of the second oxidizer supplied per time unit so that the oxygen content supplied via the second oxidizer constitutes at least 50 percent by weight of the total supplied oxygen per time unit in the furnace. | 2012-04-05 |
| 20120082947 | CANDLE ASSEMBLY AND FUEL ELEMENT THEREFOR - A candle assembly comprises a fuel element having a first surface, a second surface disposed opposite the first surface, and a channel extending through the fuel element from the first surface to the second surface. A support structure is adapted to support the first surface of the fuel element within a central portion of the support structure. A wick retainer has a flat portion with a centralized conduit extending outwardly from a top surface of the flat portion. A wick has a first end disposed within the wick retainer, wherein the wick and wick retainer are embedded in the fuel element prior to use such that a second end of the wick extends outwardly beyond the second surface of the fuel element. | 2012-04-05 |
| 20120082948 | MASK, METHOD AND APPARATUS FOR FORMING SELECTIVE EMITTER OF SOLAR CELL - The present invention discloses a method and an apparatus for forming a selective emitter of a solar cell. The apparatus for forming a selective emitter of a solar cell in accordance with the embodiment of the present invention includes: a transport means configured to transport a substrate having a first emitter layer formed on an upper surface thereof, the first emitter layer having n-type impurities diffused and formed therein, a table configured to be supplied with the substrate from the transport means and to support the supplied substrate, a mask, being placed on the upper side of the first emitter layer and having a patterned opening, and a ramp, being located above the table and applying a heat energy to the first emitter layer that is exposed though the mask. | 2012-04-05 |
| 20120082949 | ORTHODONTIC BRACES - Orthodontic braces including a plaque | 2012-04-05 |
| 20120082950 | SYSTEMS AND METHODS FOR INTRA-ORAL DRUG DELIVERY - Systems and methods are disclosed for intra-oral delivery of drugs. | 2012-04-05 |
| 20120082951 | ORTHODONTIC KIT AND METHODS FOR SAME - A method for providing orthodontic therapy. The method includes the steps of providing a kit that includes an enclosure and tools and components for providing orthodontic therapy using braces to a single patient, applying the braces to the single patient's teeth using the tools, placing the tools back into the kit, storing the kit, and reusing the kit at all of the single patient's subsequent visits during the term of the orthodontic therapy. | 2012-04-05 |
| 20120082952 | METHOD FOR EXPANDING BONE CREST AND AN IMPLANT-EXPANDER FOR USE IN SAID METHOD - Method for expanding bone crest ( | 2012-04-05 |
| 20120082953 | PLACEMENT TOOL - The present invention provides an improved pre-loaded placement tool ( | 2012-04-05 |
| 20120082954 | Composition Comprising a Monomer with a Polyalicyclic Structure Element for Filling and/or Sealing a Root Canal - A curable dental composition comprising a monomer with a polyalicyclic structure element that can be used for filling and/or sealing of a root canal is described. Also described is a composition useful as a dental material and a method for preparing such a composition. New polymerizable monomers comprising at least one polyalicyclic structure element and certain ethylenic structure elements, which are particularly suitable for use in a dental composition, and the use of the new monomers in a dental composition are also described. | 2012-04-05 |
| 20120082955 | SALIVA SUCTION SYSTEM - A saliva suction system includes a suction head, a container, a pump, a controller and two tubes. The suction head has an outline fitting a lower jaw. The suction head is provided with a plurality of inlet holes and an outlet hole. The inlet holes communicate with the outlet hole. The tubes are separately disposed between the pump and the suction head and between the pump and the container. The controller makes the pump turn on or off. The saliva suction system further includes a timer and a sensor for automatic or intermittent control. | 2012-04-05 |
| 20120082956 | DENTAL IMPLANTS - A dental implant has a dental implant fixture with a fitting hole at the oral cavity-side end, and an abutment with a fitting portion at one end which is to be fitted, not to be rotatable, in the fitting hole in the dental implant fixture. | 2012-04-05 |
| 20120082957 | DENTAL MODEL ARTICULATOR - Disclosed is a dental model articulator configured to combine maxillary and mandibular dental model casts with each other. The dental model articulator includes a frame, an arm member rotatably and reciprocatively supported to the frame, an elastic bias unit frontward elastically pressing the arm member with respect to the frame, a first connecting unit formed in the arm member to be connected with the maxillary dental model cast, and a second connecting unit connected to the frame to move reciprocatvely through at least one penetration hole and combined with the mandibular dental model cast. | 2012-04-05 |
| 20120082958 | Composite Material Comprising a Monomer with a Polyalicyclic Structure Element - A composite material and method of making and using the same is described. In particular a dental (and preferably photocurable) composite material, and the use of a composite material according to the invention as a dental material and a method for preparation of a composite material according to the invention. Also disclosed are novel radically polymerizable monomers comprising at least one polyalicyclic structure element and certain ethylenic structure elements, which are particularly suitable for use in a composite material according to the invention. | 2012-04-05 |
| 20120082959 | Polymerizable Compounds Comprising a Polyalicylic Structure Element - Novel polymerizable compounds comprising a polyalicyclic structure element and certain functional groups, mixtures comprising one or a plurality of these compounds and corresponding curable blends and products as well as their respective use as dental material or for the preparation of a dental material are described. A method for preparing these compounds or mixtures and a method for preparing a product, preferably a product suitable for dentistry, are also described. | 2012-04-05 |
| 20120082960 | EARLY LEARNING TOOLS AND KITS INCLUDING MANIPULATOR DEVICES FOR ORGANIZED PLAY - Disclosed are manipulator devices for use in learning games, and kits utilizing the same. The manipulator devices my be a substantially elongated and flat body formed of flexible material and at least partially stuffed to resemble a bean bag. The body is adapted to be capable of manipulation between an unfolded position and a folded position, where the folded position conceals an identifiable attribute of the device selected from the group consisting of a number or a symbol. The kits may include three or more manipulator devices each having at least two attributes identifiable by children and allowing them to associate the plurality of devices into subsets according to shared types of these attributes. | 2012-04-05 |
| 20120082961 | METHOD AND SYSTEM FOR PROVIDING INCENTIVES IN A BUSINESS ENVIRONMENT - A method, comprising the steps of (a) representing users within a virtual environment, the virtual environment residing on one or more computers, comprising the steps of (b) collecting data pertaining to one or more of the users' activities not associated with the virtual environment relating to each of the users' performance on business-related tasks, (c) awarding incentives including points, badges, levels, prizes, etc. to a plurality of users in the virtual environment based on the collected data pertaining to the users, (d) providing information regarding a first user's incentives to at least a second user involved in activities related to the business-related tasks performed by the first user, and (e) updating the collected data in the virtual environment as the data pertaining to the performance of users changes. | 2012-04-05 |
| 20120082962 | BRAILLE ERASURE MECHANISM - An improved Braille erasure mechanism may comprise a reverse-embosser or impressing mechanism to imprint a negative Braille cell. A negative Braille cell is the reverse of a normal Braille cell, with one or more dots lowered or pressed into the printing medium in an opposite direction to the raised dots of a normal Braille cell. Because the dots of a negative Braille cell are lowered past the surface of the printing medium, they may be ordinarily undetectable to the fingers of a Braille user. Accordingly, by imprinting a full negative Braille cell on top of a Braille cell to be erased, all of the previously raised dots of the Braille cell may be lowered beyond the surface of the printing medium. Any further Braille cell embossed over the erased cell will be free from corruption, because any dot not used by the new cell will remain lowered and undetectable. | 2012-04-05 |
| 20120082963 | ANTENNA CALCULATION INTERFACE - A reader is proposed that includes a reader core having a web server provided thereon. The web server is made accessible to users via an advertised IP address. One set of scripts made available via the web server provide a user with the ability to optimize a tuning network for the reader. | 2012-04-05 |
| 20120082964 | ENHANCED GRAPHOLOGICAL DETECTION OF DECEPTION USING CONTROL QUESTIONS - A method for enhanced graphological detection of deception is disclosed, including collecting handwritten answers to control questions and test questions from a subject. In certain embodiments of the invention, the collection of answers is accomplished with a handwriting tablet that can provide digital output. Next, the control input is analyzed so as to generate control handwriting feature data, and the test input is analyzed so as to generate test handwriting feature data. Next, test handwriting feature data resembling control handwriting feature data is designated to be non-deception-related, and test handwriting feature data not resembling control handwriting feature data is designated to be potentially deception-related. Finally, potentially deception-related test handwriting feature data is analyzed using graphological analysis, thereby identifying deception-related test handwriting data, and deception data is generated therefrom. A system for executing the method is also disclosed, which in some embodiments is a computer system. | 2012-04-05 |
| 20120082965 | "AD LITTERAM" METHOD - A method to teach a language may include the steps of selecting a predetermined letter sound to be evaluated, providing a first predetermined word which exhibits the predetermined letter sound, adding a first predetermined diacritic character to the first predetermined word and generating a predetermined word deleting the letters having the first predetermined diacritic character. The predetermined letter sound may be a short vowel, and the predetermined letter sound may be a long vowel. The predetermined letter sound may a long I, the predetermined letter sound may be a closed A. The predetermined letter sound may be a closed O, and the predetermined letter sound may be a vowel pronounced as a schwa. The predetermined letter sound may be the letter O, and the predetermined letter sound may be an alternate consonant. The predetermined letter sound may be a silent letter. | 2012-04-05 |
| 20120082966 | LITERACY SYSTEM - A literacy system provides teaching for reading and writing skills. In one embodiment, the literacy system may include exercises for teaching visual sequencing, motor skills, phonology, semantics, syntax, and text. The literacy system may have a pre-reading section, which includes exercises for developing visual sequencing skills and motor skills prior to teaching the skills of reading and writing words. | 2012-04-05 |
| 20120082967 | METHOD AND SYSTEM FOR TRAINING A GAS TURBINE ENGINE TEST CELL OPERATOR - A method for training a gas turbine engine test cell operator during a simulated engine test is provided. The method includes transmitting, from a data acquisition and control system (DACS) to a software engine model, data indicative of at least one of an operator input and an instructor input. The method further includes receiving the data at the software engine model and transmitting response data from the software engine model to the DACS, the response data simulating to the DACS that an operational state of a live engine has changed in response to the at least one of an operator input and an instructor input. The method also includes receiving the response data at the DACS and outputting an indication of the changed operational state to the operator based on the response data. | 2012-04-05 |
| 20120082968 | Journal System - A journal system for promoting a person's personal growth and a method for guiding a journal user to use a journal are provided. The journal system includes a plurality of cards, each card having a writable portion configured to receive an entry from a user and a written content portion. The written content portion includes a prompt to the user and an intention relating to the prompt to facilitate the entry from the user. | 2012-04-05 |
| 20120082969 | SIMULATION OF AN INVASIVE PROCEDURE - Apparatus, including: a mockup probe, having a distal end and a proximal end adapted to be held by a human operator. The apparatus further includes a mockup patient, simulating an actual patient, the mockup patient having an aperture allowing penetration of the distal end of the mockup probe into the mockup patient. The apparatus includes a force generator, coupled to the mockup probe so as to apply a force to the proximal end that can be felt by the human operator, and a system controller. The controller is configured to: track a location of the distal end during the penetration thereof into the mockup patient, access an indication of a value of contractility of a region of an organ of the actual patient corresponding to the location, and activate the force generator so that the force applied to the proximal end corresponds to the indication. | 2012-04-05 |
| 20120082970 | PORTABLE LAPAROSCOPIC TRAINER - A portable surgical training device is provided. The trainer includes a top cover spaced apart from a base to form a simulated body cavity for locating model organs that are substantially obscured from the field of view of the user. The top cover includes a video display, fixed insertion ports and interchangeable inserts containing simulated tissue layers. The training device has open sides for demonstrating and training lateral surgical techniques including a simulated or live tissue colon attached to a support leg for simulating transanal minimally invasive surgery. A training endoscope with an adjustable focal length for use with the trainer and, in particular, with optical trocars is disclosed. The surgical trainer can be angled and is well suited for training laparoscopic surgery techniques and demonstrating surgical instruments. | 2012-04-05 |
| 20120082971 | PLANTING TOY KIT - A planting toy kit is composed of hydrophobic fine sand, a phosphate solution and a tree. In use, the hydrophobic fine sand is first made into a mound or place in a proper container. Then a well is made in the sand mound to receive the phosphate solution. The phosphate solution forms a pool marvelously instead of mixing with the hydrophobic fine sand. The tree is afterward planted in the phosphate solution. As the phosphate solution is slowly absorbed by the tree, the phosphate solution gradually crystallizes and gives a snowy appearance to the tree. The planting toy kit breaks the stereotype that sand mixes with water so as to be not only educational for it allows users to experience the pleasure of tree planting and watering, but also amusing for it shows an exterior transformation of the tree. | 2012-04-05 |
| 20120082972 | MODULAR ROBOTICS DESIGN AND DEVELOPMENT SYSTEM WITH VARYING LEVELS OF COMPLEXITY - A modular educational robotics design and experimentation system is disclosed herein. The disclosed system includes a chassis onto which a plurality of components can be mounted. Components can be logical components, sensors, output components such as motors, or other kinds of components. In various embodiments, components can be electrically connected to one another by wires that may have varying diameters and connection technologies depending on the contemplated age of the users of the system. The wires may also include a feature to indicate when they are connected in an allowable fashion. In addition, components may be mechanically connected to one another using proprietary connector technology in which uprights having stems with a particular shape can be tightened to the chassis using thumbscrews. The disclosed system advantageously enables students of varying ages to experiment with robotics concepts using modules optimized for certain tasks and ages of users. | 2012-04-05 |
| 20120082973 | INTERACTIVE VIRTUAL CLASSROOM PROVIDING MULTIDIRECTIONAL AND SELF-DIRECTED SCRIPTED LEARNING - The present invention discloses an interactive virtual classroom for scripted self-directed learning and education. While self-directed learning is often unidirectional or bidirectional, this application features a multi-directional learning approach. The multidirectional approach involves interaction with virtual classmates that are programmed with artificial intelligence (AI). Interaction can be between the instructor and the user student, the user student and the AI students, the instructor and the AI students, between the AI students. The content provided within the classroom is scripted and customized depending on what is being taught. | 2012-04-05 |
| 20120082974 | ELECTRONIC TEACHING SYSTEM - Systems, methods, and apparatus that couple portable educational terminal(s) with an instructor interface by way of an interactive, real-time educational system are presented herein. An educational component can be configured to authorize, via a network computing environment, a first communication between the educational component and an educational terminal; authorize, via the network computing environment, a second communication between the educational component and an instructor interface; and transfer, via the network computing environment, educational path information between the educational terminal and the educational component in response to the second communication. The educational path information can include digitized textbook information and/or relate to a lesson plan associated with the educational terminal. Further, the educational component can be configured to authorize the first communication in response to at least one of an alphanumeric registration, a voice activated registration, a biometric registration, or first information associated with the educational terminal. | 2012-04-05 |
| 20120082975 | DNA-BASED MOLECULAR SWITCHES AND USES THEREOF - Disclosed are nucleic acid-based molecular switches that respond to changes in pH. The switches may be used in DNA nanodevices. The switches may also act as sensors for measuring the pH of a sample, including cells, regions thereof, and whole organisms. The switch includes an A-motif that forms at acidic pH. Also disclosed are compositions and methods for measuring the pH of cells or regions thereof, such as vesicles, the nucleus, mitochondrial matrix, or the Golgi lumen. | 2012-04-05 |
| 20120082976 | METHOD OF SCREENING FOR INSULIN SECRETION-POTENTIATING AGENTS - Disclosed are a novel method of screening for insulin secretion-potentiating agents as well as means for performing such screening. The means include a DNA encoding fluorescent-labeled Epac2 comprising two different DNAs encoding two different fluorescent proteins which emit fluorescent light with wavelength differing from each other and a DNA encoding Epac2 which are fused together in-frame, and the cells transformed with the DNA. Also disclosed is a method of screening insulin secretion-potentiating agents comprising bringing a candidate compound into contact with cells transformed with the said DNA, and detecting whether the compound binds to Epac2. | 2012-04-05 |
| 20120082977 | ARTICLES WITH MATRIX COMPRISING A CELL EXTRACTANT AND BIODETECTION METHODS THEREOF - Articles are provided for the detection of cells in a sample. The articles include a release element. The release element comprises an encapsulating agent and a cell extractant. The release element controls the release of the cell extractant into a liquid mixture containing the sample. Methods of use are also disclosed. | 2012-04-05 |
| 20120082978 | Cell Analysis On Microfluidic Chips - The present invention provides for a method of implementing fluorescent in situ hybridization (FISH) or other cellular analysis processes using intact cells within a microfluidic, chip-based, apparatus. The invention further provides for a method of cellular immobilization within a microfluidic device. Also provided is a method for automated analysis of FISH or other cellular analysis using discrete colormetric probes. | 2012-04-05 |
| 20120082979 | COMPOSITIONS, METHODS, AND KITS FOR (MIS)LIGATING OLIGONUCLEOTIDES - Methods, reagents, and kits for (mis)ligating oligonucleotide probes or for identifying at least one target nucleotide are disclosed. One can enhance the generation of misligation product using a ligase under reaction conditions and with reagents where that particular ligase is prone to misligation. Alternatively, one can decrease or avoid generating misligation products using a particular ligase under reaction conditions and using reagents where that ligase is at least less prone to misligation. In certain embodiments, the recombinant ligase from | 2012-04-05 |
| 20120082980 | PNA Probes, Probe Sets, Methods and Kits Pertaining to the Detection of Candida - This invention is related to novel PNA probes, probe sets, methods and kits pertaining to the detection of one or more species of | 2012-04-05 |
| 20120082981 | ENZYME MIXTURE - Polymorphisms are present throughout an organism's genome, and understanding which alleles are present in a particular organism's genome can be advantageous. When probing the identity of these alleles, one must minimize incorrect readings due to inefficiencies in the system. In hydrolysis probe applications, these inefficiencies may be due to over-activity of an exonuclease functionality that excises nucleotides from probes that are only partially, complementary to a region of a target. The present invention provides a mixture that contains a plurality of polymerases including one that has a 5′→3′ exonuclease functionality and one that lacks or substantially lacks it, each in a sufficient relative amount and concentration to increase efficiencies of the system. | 2012-04-05 |
| 20120082982 | CYSTIC FIBROSIS GENE MUTATIONS - The present invention provides novel mutations of the CFTR gene related to cystic fibrosis or to conditions associated with cystic fibrosis. Also provided are probes for detecting the mutant sequences. Methods of identifying if an individual has a genotype containing one or more mutations in the CFTR gene are further provided. | 2012-04-05 |
| 20120082983 | Microbial Reductive Dehalogenation of Vinyl Chloride - Compositions and methods are provided that relate to the bioremediation of chlorinated ethenes, particularly the bioremediation of vinyl chloride by | 2012-04-05 |
| 20120082984 | NUCLEIC ACIDS FOR DETECTION AND DISCRIMINATION OF GENOTYPES OF CHLAMYDOPHILA PSITTACI - Methods of detecting | 2012-04-05 |
| 20120082985 | Sensing And Identifying Biological Samples On Microfluidic Devices - A method, system, and apparatus for analysis of a biological sample includes receiving the sample, wherein the sample includes deoxyribonucleic acid (DNA), lysing the sample to obtain access to the DNA included in the sample, purifying the DNA in the sample to isolate the DNA from other components in the sample, amplifying the DNA, separating fragments of the amplified DNA, detecting the separated fragments using laser induced fluorescence, based on the detecting, generating a profile of the DNA in the received sample, comparing the generated profile with profiles of DNA stored in a database, and upon determining that the generated profile matches one of the stored profiles, identifying the source from which the stored profile was obtained, wherein the receiving, lysing, purifying, amplifying, and detecting are performed on corresponding portions of a microfluidic device, and wherein transporting the sample and the DNA to the portions of the microfluidic device and enabling the lysing, purifying, amplifying, separating, detecting, generating, comparing, and identifying are performed automatically without user interaction. | 2012-04-05 |
| 20120082986 | CELL PROLIFERATION INHIBITOR - The present inventors revealed a TTF-1-specific oncogenic process by elucidating the molecular mechanism regulated by the master regulatory factor TTF-1. The present inventors focused on the elucidation of the essence of the lineage-specific survival signal which is a novel canceration signal. Thus, the present inventors found that the expression of ROR1, which is a receptor tyrosine kinase, is induced by the master regulatory factor TTF-1, and demonstrated the presence of a characteristic canceration signal transduction system. | 2012-04-05 |
| 20120082987 | Transgenic Non-Human Animals Expressing Human Blood Clotting Factors and Uses Thereof - The present invention relates, in general, to development of non-human transgenic animals expressing a human blood clotting factor, such as Factor VIII, Factor VII, Factor IX and von Willebrand factor. The invention further provides methods of detecting immunogenic events against human blood clotting factor using the transgenic animals described. | 2012-04-05 |
| 20120082988 | HOMOGENEOUS ANALYTE DETECTION - The present invention provides novel binding pair compositions of defined and limited stability comprising nucleic acid detection markers useful for the homogeneous, sensitive detection of analytes. Also provided are methods for the sensitive homogenous detection of analytes, particularly analytes of clinical relevance. Kits for preparing binding pairs of the invention and for performing the methods of the invention are also provided. | 2012-04-05 |
| 20120082989 | USES FOR LONG POLAR FIMBRIAE GENES OF PATHOGENIC ESCHERICHIA COLI STRAINS - Provided are methods for identifying lpf genes in pathogenic serotypes of the Enterobacteriaceae family and for differentiating | 2012-04-05 |
| 20120082990 | Recombinase Polymerase Amplification - This disclosure describes related novel methods for Recombinase-Polymerase Amplification (RPA) of a target DNA that exploit the properties of recombinase and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling or thermophilic enzymes. Further, the improved processivity of the disclosed methods may allow amplification of DNA up to hundres of megabases in length. | 2012-04-05 |
| 20120082991 | DETECTION OF RNA-INTERACTING REGIONS IN DNA - The present invention provides methods and kits for detecting RNA-interacting regions in genomic DNA. | 2012-04-05 |
| 20120082992 | EQUINE PARASITE DETECTION - The present invention provides a method of diagnosing a cyathostomin infection, said method comprising the step of identifying a level of anti-cyathostomin larval antigen antibodies in a sample, wherein a level of anti-cyathostomin larval antigen antibodies is indicative of a cyathostomin infection. | 2012-04-05 |
| 20120082993 | DETECTING CANCER WITH ANTI-CXCL16 AND ANTI-CXCR6 ANTIBODIES - Methods for detecting cancer or monitoring cancer progression in a subject are disclosed. The method includes detecting the level of expression of one or more cancer markers in a biological sample obtained from the subject; and comparing the level of expression of the one or more cancer markers in the biological sample to a normal level of expression of the one or more cancer markers. The one or more cancer markers comprises CXCL16 or CXCR6 or both CXCL16 and CXCR6. Also disclosed is a kit for detecting cancer or monitoring cancer progression. | 2012-04-05 |
| 20120082994 | Expression Levels of COL4A1 and other Markers Correlating with Progression or Non-Progression of Bladder Cancer - Disclosed is determining expression levels protective or harmful markers for bladder cancer prognosis; particularly, determining the expression levels of COL4A3BP alone or in combination with the expression levels of MBNL2, FABP4, and NEK1 or other markers where increased expression levels of these protective markers relative to a control correlates with lack of bladder cancer progression and decreased expression levels correlates with bladder cancer progression or death. Also disclosed is determining the expression levels of COL4A1 alone or in any combination with the expression levels of UBE2C, BIRC5, COL18A1, KPNA2, MSN, ACTA2, and CDC25B or other markers where increased expression levels of these harmful markers relative to a control correlates with bladder cancer progression or death and decreased expression levels correlates with lack of bladder cancer progression Also disclosed are signatures of protective and harmful markers to predict likelihood of bladder cancer progression or non-progression. | 2012-04-05 |
| 20120082995 | METHOD FOR QUANTITATIVE PCR AMPLIFICATION OF DEOXYRIBONUCLEIC ACIDS FROM A SAMPLE CONTAINING PCR INHIBITORS - The present invention is directed to a method for quantitative PCR amplification of deoxyribonucleic acids (DNA) from a sample containing PCR inhibitors such as biological, clinical or environmental samples. In the method of the invention an inhibitor-tolerant DNA polymerase is used in a pre-amplification step to increase the copy number of DNA from these samples. In the pre-amplification step, the PCR reaction preferably comprises at least the same amount of effective PCR inhibitors as a reaction with 1% (v/v) human blood. The pre-amplified sample is subsequently diluted in order to dilute inhibitory substances remaining in the sample and thus rendering possible to use an aliquot of the diluted sample in quantitative PCR, which is very sensitive for these inhibitors. | 2012-04-05 |
| 20120082996 | IL-21 VARIANTS - IL-21 variants nucleic acid sequences are provided that encode a peptide having deletions and zero to ten conservative amino acid substitutions in the region of amino acid residues 65-96 of SEQ ID. NO:2. | 2012-04-05 |
| 20120082997 | TAGGANTS AND METHOD OF USING SAME - A composition of matter which comprises a non-gaseous nitrogen containing compound; and a spore of a micro-organism. A method of determining a source of a material the material being an explosive or a substance used in the preparation of the explosive, the material comprises a spore of a micro-organism uniquely associated with the material, the method comprises inducing the spore to transform into a vegetative micro-organism and identifying the micro-organism as being associated with the material, thereby determining the source of the material. | 2012-04-05 |
| 20120082998 | DETECTION OF BACTERIAL INFECTIONS IN SUBJECTS SUFFERING FROM DYSPNEA - The field of the present invention is the diagnosis and/or prediction and/or therapy follow-up of bacterial infections in subjects suffering from dyspnea. It is a subject of the present invention to provide a method for the diagnosis and/or prediction and/or therapy follow-up of bacterial infections in subjects suffering from dyspnea. | 2012-04-05 |
| 20120082999 | NEW ANTIBODY COCKTAIL - The present invention relates to a composition comprising at least three primary antibodies or fragments thereof, wherein the at least three antibodies or fragments thereof binds specifically to at least three different proteins, and wherein the at least three different proteins are AMCAR, CK 5/6, and HMWC. Methods for using the composition in diagnosis, prognosis, and assessing efficacy of treatment is further included as well as kits comprising said composition, and optionally, instructions of its use. | 2012-04-05 |
| 20120083000 | Neuropeptide Release Assay For Sodium Channels - Methods and compositions for using genetically modified non-human animals are provided, wherein the genetic modification comprises a humanization of the one or more extracellular pore loops of a Na | 2012-04-05 |
| 20120083001 | METHOD FOR TRANSPORTING POTASSIUM IONS FROM FRONT SIDE TO BACK SIDE OF LIPID BILAYER MEMBRANE - An object of the present invention is to detect a specific chemical substance with high sensitivity and high precision. By using a specific lipid bilayer membrane, a chemical substance is detected with high sensitivity and high precision. Here, the specific lipid bilayer membrane comprises a chemical substance receptor, a chimeric G protein, and a potassium ion channel. The chimeric G protein comprises a chimeric G | 2012-04-05 |
| 20120083002 | Methods For Modulating The Development Of Dopamine Neuron By The Dopamine D2 Receptor And Compositions Thereof - The present invention relates to a composition for modulating the activation of Nurr1, the composition comprising an agonist or an antagonist of a dopamine D2 receptor, methods for modulating the activation of Nurr1 by the dopamine D2 receptor, a method and composition for treating Nurr1-related diseases using the dopamine D2 receptor, and methods for screening a modulator of a dopamine D2 receptor of a test compound. Accordingly, the activation of Nurr1 can be modulated by treating the dopaminergic neurons with the agonist or the antagonist of the dopamine D2 receptor, thereby enhancing or inhibiting generation of the dopaminergic neurons. | 2012-04-05 |
| 20120083003 | PARKIN SUBSTRATE AND ASSAY - The invention provides in vitro, ex vivo, and in vivo assays for Parkin activity, in which Parkin-mediated ubiquitination of a Sept4 protein is measured. The assays may be used to screen for agents that modulate Parkin protein ligase activity. | 2012-04-05 |
| 20120083004 | Diagnostic Method for Celiac Sprue - Detection of toxic gluten oligopeptides refractory to digestion and antibodies and T cells responsive thereto can be used to diagnose Celiac Sprue. | 2012-04-05 |
| 20120083005 | METHODS FOR IN VITRO CANCER CELL DETECTION, DIAGNOSIS AND THERAPY USING MULTIDOMAIN BIOTAGS - In one embodiment, a biotag for targeting a cancer biomarker is provided. The biotag may include a cancer biomarker binding domain, an internalization domain, an endosomal escape domain, a lysosomal escape domain, a reporter binding domain, and a reporter, wherein the reporter is a diagnostic agent. In some aspects, the cancer biomarker is ERBB 1-4, EGFRvIII or Transferrin Receptor (TfR). In other aspects, the binding domain is an scFv, an sdFv, a CDR or an SDR modified CDR. In some aspects, the reporter binding domain is a metal binding domain, which may be chelated to a metal nanoparticle tag. In some aspects, the metal nanoparticle tag is a noble metal, a superparamagnetic metal, a core-shell nanoparticle, or a fluorescent agent. In another embodiment, a targeted contrast composition for use with a diagnostic imaging technique is provided, which includes a contrast agent and a biotag for targeting a cancer biomarker. | 2012-04-05 |
| 20120083006 | METHODS FOR THE IDENTIFICATION OF KINASE INTERACTING MOLECULES AND FOR THE PURIFICATION OF KINASE PROTEINS - The present invention relates to immobilization compounds (I), immobilization products and preparations thereof as well as methods and uses for the identification of kinase interacting compounds or for the purification or identification of kinase proteins. | 2012-04-05 |
| 20120083007 | Basophil Activation Based Allergy Diagnostic Test - Methods are provided for determining a subject's susceptibility to an allergic reaction upon exposure to an offending allergen. Methods are also provided for determining and monitoring a subject's responsiveness to ongoing allergy treatment. | 2012-04-05 |
| 20120083008 | Methods for obtaining molecules with reduced immunogenicity - The invention provides a method for reducing immunogenicity of a peptide, protein or protein complex in an individual comprising introducing at least one cross-link between two amino acids in the peptide, protein or protein complex that is stable or irreversible in vivo, wherein the at least one cross-link reduces the immunogenicity of the peptide, protein or protein complex in the individual compared to an identical peptide, protein or protein complex not so cross-linked. | 2012-04-05 |
| 20120083009 | Rheumatoid Arthritis Test Method And Treating Method - To evaluate the prognosis of rheumatoid arthritis based on the evaluation of the disease severity of the patient to select a treatment method suitable for each rheumatoid arthritis patients, and to measure HSC71 protein levels of the patients before and after the administrations of therapeutic agents to determine the efficacy of various therapeutic agents for each of rheumatoid arthritis patients and to use thereof as a remedy for preventing onset and progression of rheumatoid arthritis. | 2012-04-05 |
| 20120083010 | METHOD FOR DIAGNOSING POMPE DISEASE - Provided is a method for diagnosing Pompe disease in a patient by measuring acid α-glucosidase activity in a sample from the patient. The invention also provides a method for monitoring the treatment of Pompe disease with specific pharmacological chaperones by measuring acid α-glucosidase activity in a sample from the patient. | 2012-04-05 |
| 20120083011 | Sensitive Methods for Detecting The Presence of Cancer - Described herein are sensitive methods for determining if a subject has cancer. The methods generally involve quantifying the amount of one or more biomarkers derived from Galectin-3 in a biological sample from the subject by mass spectrometry, wherein an increase in the amount of one or more biomarkers in the biological sample as compared to a control is an indication of the presence of cancer in the subject. | 2012-04-05 |
| 20120083012 | Expression System for Producing Multi-Enzyme Complexes and Uses Thereof - An expression system for producing a multi-enzyme complex, the system including a nucleic acid molecule containing a promoter operatively linked to a nucleotide sequence including multiple genes encoding multiple enzymes that are components of the multi-enzyme complex. | 2012-04-05 |
| 20120083013 | GLUCOSYLTRANSFERASE SPECIFIC TO POSITION-4 OF FUROFURAN-TYPE LIGNAN, AND POLYNUCLEOTIDE ENCODING SAME - The invention provides a polynucleotide encoding a furofuran lignan 4-O-glucosyltransferase, and others. The polynucleotide in accordance with the present invention comprises a polynucleotide consisting of the nucleotide sequence represented by SEQ ID NO: 3 or SEQ ID NO: 5, or a polynucleotide encoding a protein consisting of the amino acid sequence represented by SEQ ID NO: 4 or SEQ ID NO: 6. | 2012-04-05 |
| 20120083014 | Nicotiana Benthamiana Plants Deficient in Xylosyltransferase Activity - The invention provides | 2012-04-05 |
| 20120083015 | ANTIBODIES AGAINST HUMAN TWEAK AND USES THEREOF - An antibody binding to TWEAK comprising as heavy chain variable domain a CDR3H selected from the group consisting of SEQ ID NO: 8, 16 or 24. | 2012-04-05 |
| 20120083016 | METHOD FOR TRACING GRAM-NEGATIVE BACTERIA INSIDE ANIMAL MODEL USING STABLE AND BIOLUMINESCENCE-BASED EXPRESSION SYSTEM THEREFOR - A method of creating a biotechnological product and an efficient and stable bio-luminescence vector which could be used for tracking Gram-negative bacteria when distributing inside animal body are provided. Through conjugation, this auto-luminescence vector can be easily transmitted from bacteria to bacteria among Gram-negative bacteria, and may facilitate bacteria to be luminescence-labeled for subsequently analyzing the dynamic change of bio-luminescent bacteria within animal body in vivo. This system includes a lacZ promoter-driven luxABCDE, a high copy number of ColE1 replicon, and a high plasmid stability of the conjugative and broad host-ranged plasmid pSE34 from | 2012-04-05 |
| 20120083017 | ASYMMETRIC ADAPTER LIBRARY CONSTRUCTION - The present invention provides methods and compositions for asymmetrically tagging a nucleic acid fragment using asymmetric adapters. | 2012-04-05 |
| 20120083018 | THERMOSTABLE DNA POLYMERASES AND METHODS OF USE - Thermostable viral and microbial polymerases exhibiting a combination of activities selected from proofreading (3′-5′) exonuclease activity, nick translating (5′-3′) nuclease activity, synthetic primer-initiated polymerase activity, nick-initiated polymerase activity, reverse transcriptase activity, strand displacement activity, terminal transferase activity, primase activity, and/or efficient incorporation of chain terminating analogs. Some of the polymerases provided herein include a first motif and a second motif. The first motif preferably has the sequence X | 2012-04-05 |
| 20120083019 | Use of Glycoside Hydrolase 61 Family Proteins in Processing of Cellulose - The invention provides recombinant GH61 proteins obtained from | 2012-04-05 |
| 20120083020 | MANIPULATION OF GENES OF THE MEVALONATE AND ISOPRENOID PATHWAYS TO CREATE NOVEL TRAITS IN TRANSGENIC ORGANISMS - Disclosed are the uses of specific genes of the mevalonate and isoprenoid biosynthetic pathways, and of inactive gene sites (the pseudogene) to (1) enhance biosynthesis of isopentenyl diphosphate, dimethylallyl diphosphate and isoprenoid pathway derived products in the plastids of transgenic plants and microalgae, (2) create novel antibiotic resistant transgenic plants and microalgae, and (3) create a novel selection system and/or targeting sites for mediating the insertion of genetic material into plant and microalgae plastids. The specific polynucleotides to be used, solely or in any combination thereof, are publicly available from GeneBank and contain open reading frames having sequences that upon expression will produce active proteins with the following enzyme activities: (a) acetoacetyl CoA thiolase (EC 2.3.1.9), (b) 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase (EC 4.1.3.5), (c) HMG-CoA reductase (EC 1.1.1.34), (d) mevalonate kinase (EC 2.7.1.36), (e) phosphomevalonate kinase (EC 2.7.4.2), (f) mevalonate diphosphate decarboxylase (EC 4.1.1.33), (g) isopentenyl diphosphate (IPP) isomerase (EC 5.3.3.2), and (h) phytoene synthase (EC 2.5.1.32). | 2012-04-05 |
| 20120083021 | Low odor coating compositions and paints - This invention provides low odor stable coating compositions, and methods of their production. The stable aqueous coating compositions and paints comprise one or more emulsion-polymerized addition polymer and one or more carboxylesterase enzyme having an ester hydrolysis activity in the composition of less than 0.03 micromole/minute, wherein the aqueous coating composition has a headspace volatile organic compound (VOC) content, as measured by headspace gas chromatography-mass spectrometry (GC-MS) at 33° C., of less than 10 ppm of the one or more organic carboxylester with a normal boiling point of less than 150° C. and more than 50 ppm of the one or more mono-alcohol with a formula molecular weight of less than 76. | 2012-04-05 |
| 20120083022 | Methods for Increasing the Production of Ethanol from Microbial Fermentation - A stable continuous method for producing ethanol from the anaerobic bacterial fermentation of a gaseous substrate containing at least one reducing gas involves culturing in a fermentation bioreactor anaerobic, acetogenic bacteria in a liquid nutrient medium; supplying the gaseous substrate to the bioreactor; and manipulating the bacteria in the bioreactor by reducing the redox potential, or increasing the NAD(P)H TO NAD(P) ratio, in the fermentation broth after the bacteria achieves a steady state and stable cell concentration in the bioreactor. The free acetic acid concentration in the bioreactor is maintained at less than 5 g/L free acid. This method allows ethanol to be produced in the fermentation broth in the bioreactor at a productivity of greater than 10 g/L per day. Both ethanol and acetate are produced in a ratio of ethanol to acetate ranging from 1:1 to 20:1. | 2012-04-05 |
| 20120083023 | Microbial Oil Production From Biomass Hydrolysate By Oleaginous Yeast Strains - Oleaginous yeast strains are used to hydrolyze biomass (e.g. wheat straw) that has been pretreated using dilute acid, in order to produce lipids. The lipids may be used as feedstock for producing biofuels. | 2012-04-05 |
| 20120083024 | Materials and Methods for Synthesis of a Flavor and Aroma Volatile in Plants - The subject invention concerns polynucleotides encoding a plant 2-phenylethanol dehydrogenase enzyme. In one embodiment, the polynucleotide encodes a tomato 2-phenylethanol dehydrogenase. The subject invention also concerns polynucleotides encoding a plant phenylalanine decarboxylase enzyme. In one embodiment, the polynucleotide encodes a tomato phenylalanine decarboxylase. The subject invention also concerns 2-phenylethanol dehydrogenase polypeptides and phenylalanine decarboxylase polypeptides encoded by polynucleotides of the present invention. The subject invention also concerns methods for providing a plant with an increased flavor and aroma volatile. Plants can be transformed with one or more polynucleotide of the present invention. The subject invention also concerns these transformed plant cells, plant tissue, and plants and transgenic progeny thereof. | 2012-04-05 |
| 20120083025 | Hybrid Enzymes - The present invention relates to hybrid polypeptides having a first amino acid sequence having endo-amylase activity and a second amino acid sequence having carbohydrate binding activity. The present invention also relates to the use of the hybrid polypeptides in starch processing and baking. | 2012-04-05 |
| 20120083026 | Method for removing CO2 from a smoke or exhaust gas of a combustion process - A method and arrangement for removing CO | 2012-04-05 |
| 20120083027 | Basic Protein Purification Tags from Thermophilic Bacteria - The invention is related to a method for purification of recombinant proteins using highly basic proteins from thermophilic bacteria as purification tags for use in a cation-exchange chromatography purification step. The basic proteins may be ribosomal proteins. The recombinant proteins are expressed in eukaryotic or prokaryotic host cells. The purification tag will typically have a pl above about 9 and comprise from about 15 to about 250 amino acid residues. | 2012-04-05 |
| 20120083028 | DEVICE FOR FECAL OCCULT BLOOD TEST - A devise for fecal occult blood test comprises a first and a second casings, a sampling portion extending from the first casing, a specimen processing portion, at least a testing portion and a packing cylindrical member. The packing cylindrical member is coupled between the first and second casings when unused and dismantled therefrom when used. After sampling via a specimen collecting portion of the sampling portion, the specimen collecting portion is drawn into the first casing to reduce the device size. The first and second casings are fixedly coupled together in a specimen processing position thereof to mix specimens with a liquid of the specimen processing portion into a testing liquid, and then in a specimen testing position thereof to disperse onto the testing portions for testing and directly display test results. The present invention advantages high accuracy, rather hygiene, significant size reduction, real-time testing-result display and convenient use. | 2012-04-05 |
| 20120083029 | ROTATING CULTURE VESSEL AND AUTOMATIC CELL CULTURE APPARATUS USING SAME - Disclosed is a rotating culture vessel based on a rotating culture technology using an RWV, by which cell seeding, liquid medium exchange, quality control and so on can be automated and degassing can be conducted simultaneously with liquid medium exchange without disturbing the cells under culture. Also disclosed is an automatic cell culture apparatus using the same. A rotating culture vessel, which contains cells and a liquid culture medium, to be attached to a horizontal rotating shaft of a rotating culture device to three-dimensionally culture the cells, wherein one or more inlets/outlets for supplying cells and a liquid culture medium at the early stage and then taking out the cultured cells, are formed at appropriate position of a flat cylindrical culture container; at least one pair of a supply port and a discharge port for liquid medium exchange is provided on the outer circumferential cylindrical face of the culture container. | 2012-04-05 |
| 20120083030 | INCUBATOR - An incubator comprising: a culture chamber configured to accommodate culture; a dish structure configured to contain a liquid; an ultrasonic vibrator provided in a part of the dish structure, the ultrasonic vibrator configured to atomize the liquid; and a gas-liquid contact structure configured to bring the atomized liquid into contact with air in the chamber to be cultured. | 2012-04-05 |
| 20120083031 | METHOD FOR TRACING GRAM-NEGATIVE BACTERIA INSIDE ANIMAL MODEL USING STABLE AND BIOLUMINESCENCE-BASED EXPRESSION SYSTEM THEREFOR - A method of creating a biotechnological product and an efficient and stable bio-luminescence vector which could be used for tracking Gram-negative bacteria when distributing inside animal body are provided. Through conjugation, this auto-luminescence vector can be easily transmitted from bacteria to bacteria among Gram-negative bacteria, and may facilitate bacteria to be luminescence-labeled for subsequently analyzing the dynamic change of bio-luminescent bacteria within animal body in vivo. This system includes a lacZ promoter-driven IuxABCDE, a high copy number of ColE1 replicon, and a high plasmid stability of the conjugative and broad host-ranged plasmid pSE34 from | 2012-04-05 |
| 20120083032 | EMBRYONIC STEM CELL LINE AND METHOD FOR PREPARING THE SAME - An embryonic stem cell line derived from a nucleus-transferred oocyte prepared by transferring a nucleus of a human somatic cell into an enucleated human oocyte may differentiate into various desired cell types. | 2012-04-05 |
| 20120083033 | PRODUCTION OF TRANSGENIC AVIANS USING IMPROVED RETROVIRAL VECTORS - A transgenic avian containing in its genome an exogenous nucleotide sequence which includes a promoter component and a vector with reduced promoter interference wherein the exogenous nucleotide sequence is integrated into the genome and the avian. | 2012-04-05 |
| 20120083034 | EX HOST MATURATION OF GERMLINE STEM CELLS - Methods are provided for the ex host maturation of immature germline cells into haploid gametes for restoration of fertility in patients in need thereof. | 2012-04-05 |
| 20120083035 | Modified Cell Lines for Increasing Lentiviral Titers - The present disclosure provides a method of modifying cells in order to enhance lentiviral titers, cell lines that are modified and modifying reagents. By mediating individual genes and combination thereof, lentiviral titers may be increased. | 2012-04-05 |
| 20120083036 | POLYSACCHARIDE TRANSFERASE - The present invention is predicated on the discovery that a polysaccharide transferase purified from barley seedlings can catalyze the formation of covalent bonds between different polysaccharides, including between xyloglucans and cellulose, and between xyloglucans and (1,3;1,4)-β- | 2012-04-05 |
| 20120083037 | Non-Viral Transfection Agent - The invention relates to a non-viral transfection agent comprising polymer/nucleic acid complexes and nanofibers, wherein the polymer/nucleic acid complexes are composed of at least one nucleic acid and at least one cationic polymer. The nanofibers carry the polymer/nucleic acid complexes, wherein the non-viral transfection agent is advantageously produced by means of electrospinning. The cationic polymer is favorably a polyimine or polyethyleneimine and can be modified with one or more hydrophilic polymers coupled thereto. It can also be advantageous to couple the cationic polymer with one or more carbohydrates and/or with a receptor-specific ligand. The nucleic acid is a DNA or an RNA, or a DNA or RNA derivative, advantageously a therapeutically active nucleic acid. The nanofibers are composed of biodegradable, biocompatible polymers. The nanofibers or the entire transfection agent can be provided with a polymer coating. A method for producing a non-viral transfection agent comprises the following steps: providing the polymer/nucleic acid complex, producing a spinning solution containing the polymer/nucleic acid complexes, and electrospinning. | 2012-04-05 |
| 20120083038 | Methods for Detecting the Presence or Absence of Blood - The present invention relates to methods for detecting presence, or absence, of blood. Specifically, the present invention relates to methods for detecting the presence, or absence, of blood, comprising applying a solution comprising luminol, or luminol derivative, a base, an oxidizing agent and fluorescein, or a fluorescein derivative, on a surface to be investigated for the presence of blood and detecting the presence, or absence, of blood depending on spectral response Further, the present invention relates to chemical compositions for detecting presence, or absence, of blood. Furthermore, the present invention relates to a kit for detecting presence, or absence, of blood comprising the chemical composition. | 2012-04-05 |
| 20120083039 | METHOD FOR QUANTITATIVELY DETERMINING IMPURITIES - The invention relates to a method for quantitatively determining impurities in the form of aldehydes and ketones in glycerin serving for preparing pharmaceuticals, in which the glycerin containing impurities is reacted with a derivatization reagent in a sample solution and the quantity of derivatized impurities is determined. Said method is characterized in that PFBHA, O-(2,3,4,5,6-pentafluorobenzyl)-hydroxylamine hydrochloride, is used as the derivatization reagent, the derivatizing is conducted in the presence of a solubilizer in the form of a polar organic solvent, and liquid chromatographic separation and UV detection are performed. A subject matter of the invention is also the use of glycerin, in which the content of impurities of 9 ppm or less has been determined by means of the described method in a pharmaceutical preparation. According to the invention, impurities in glycerin can be better determined. | 2012-04-05 |
| 20120083040 | OXYGEN INDICATOR FOR PARENTERAL AND ENTERAL DOSAGE FORMS - The present invention relates to an oxygen indicator in which the presence or absence of oxygen is made visible by a color change, and to the use of such oxygen indicator for monitoring parenteral and enteral dosage forms. | 2012-04-05 |
| 20120083041 | MASS SPECTROMETRY METHOD - The invention provides a mechanism for semi-quantitatively measuring individual isotopomer species of a molecule using gas chromatograph mass spectrometry. The method allows for semi-quantitatively tracking the movement of ions by measuring the individual isotopomer species of a molecule. | 2012-04-05 |
