14th week of 2019 patent applcation highlights part 7 |
Patent application number | Title | Published |
20190099429 | CENICRIVIROC FOR THE TREATMENT OF FIBROSIS - The present disclosure provides methods of treating fibrosis or a fibrotic disease or condition in a subject in need thereof comprising administering to the subject a therapeutically effective amount of cenicriviroc or a salt or solvent thereof. The fibrosis or fibrotic disease may be liver fibrosis, renal fibrosis, non-cirrhotic hepatic fibrosis, associated with non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), or emerging cirrhosis. | 2019-04-04 |
20190099430 | High Dosage Strength Tablets of Rucaparib - A tablet including high dosage of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one camsylate salt has been disclosed. | 2019-04-04 |
20190099431 | ANTI-huLRRC15 ANTIBODY DRUG CONJUGATES AND METHODS FOR THEIR USE - The present disclosure provides antibodies, antibody binding fragments, and antibody drug conjugates that bind human LRRC15, their methods of making, and their uses to treat patients having cancer. | 2019-04-04 |
20190099432 | COMPOSITIONS FOR THE TREATMENT OF CHRONIC VULVAL AND PERINEAL PAIN AND SYMPTOMS AND CONDITIONS ASSOCIATED THEREWITH - Provides herein are compositions for the treatment of chronic vulval or perineal pain, and of symptoms or conditions associated therewith, comprising an estrogen, optionally estriol, and a tricyclic antidepressant, optionally amitriptyline, formulated for topical, transdermal or transmucosal administration. Also provided are methods for the production of said compositions and to uses thereof in the treatment of chronic vulval or perineal pain, and of symptoms or conditions associated therewith. | 2019-04-04 |
20190099433 | Antibacterial Use of Halogenated Salicylanilides - The invention relates to a halogenated salicylanilide selected from closantel, rafoxanide, oxyclozanide and niclosamide and derivatives thereof including salts, hydrates, esters and the like for use in the topical treatment or prevention of infections caused by Gram-positive bacteria such as | 2019-04-04 |
20190099434 | NERIDRONIC ACID FOR TREATING COMPLEX REGIONAL PAIN SYNDROME - Oral dosage forms of osteoclast inhibitors, such as neridronic acid, in an acid or a salt form, can be used to treat or alleviate pain or related conditions, such as complex regional pain syndrome. | 2019-04-04 |
20190099435 | Inhibiting inflammation with milk oligosaccharides - A method of inhibiting inflammation with milk oligosaccharides or glycoconjugates containing the oligosaccharides. | 2019-04-04 |
20190099436 | SODIUM GLUCOSE CO-TRANSPORTER INHIBITORS AND METHODS OF THEIR USE - Sulfanyl-tetrahydropyran-based compounds, pharmaceutical compositions comprising them, and methods of their use for the treatment of diseases and disorders such as diabetes and obesity are disclosed. | 2019-04-04 |
20190099437 | METHOD FOR SUPPRESSING OBESITY, METHOD FOR TREATING OBESITY, AND METHOD FOR PROMOTING GENE EXPRESSION - The present disclosure relates to a method for suppressing obesity, which includes administering to a subject a compound represented by the following formula | 2019-04-04 |
20190099438 | COMPOSITION FOR PREVENTING OR TREATING METABOLISM DISORDERS COMPRISING LEUCONOSTOC MESENTEROIDES-PRODUCING EXOPOLYSACCHARIDE AS ACTIVE INGREDIENT - The present invention provides a prophylactic or therapeutic composition for a metabolic disorder, a composition for amplifying the amount of short-chain fatty acid in the intestine, or a composition for decreasing a ratio of bacteria belonging to the Firmicutes to bacteria belonging to the Bacteroidetes in the intestine, each containing an exopolysaccharide produced by | 2019-04-04 |
20190099439 | PHARMACEUTICAL COMPOSITION FOR TREATING HEPATITIS, LIVER FIBROSIS, AND LIVER CANCER - The present invention relates to a pharmaceutical composition for treating hepatitis, liver fibrosis, and liver cancer, which comprises the following components in parts by weight: 0.15-10 parts of vinegar-baked | 2019-04-04 |
20190099440 | METHOD FOR OLFACTORY IMPROVEMENT WITH SACCHARIDE - A method for olfactory improvement with saccharide. The saccharide is a chitin-based material, proteoglycan, glycosaminoglycan, amino monosaccharide, N-acylated amino monosaccharide or a combination thereof. | 2019-04-04 |
20190099441 | OPHTHALMOLOGICAL COMPOSITION - The present invention relates to an ophthalmological composition with high viscosity. The composition according to the invention comprises or thereby consists of hyaluronic acid or a hyaluronic acid derivative, such as for example an ophthalmologically acceptable salt of hyaluronic acid and also ectoin or an ophthalmologically acceptable ectoin derivative. The composition is further characterised in that it comprises no further pharmaceutically active ingredient. | 2019-04-04 |
20190099442 | Artificial Invaplex Formulated with Deacylated Lipopolysaccharide - Disclosed herein are artificial Invaplexes comprising deacylated lipopolysaccharides and methods of making and using thereof. | 2019-04-04 |
20190099443 | Modified Immune-Modulating Particles - The current invention involves the surprising finding that when carboxylated particles, such as carboxylated polystyrene, PLGA, or diamond particles are administered to subjects, inflammatory immune responses are ameliorated. Additionally, the present invention describes methods of treating inflammatory diseases by administering these same carboxylated particles. | 2019-04-04 |
20190099444 | COMPOSITIONS FOR THE TREATMENT OF SWEATING AND METHODS FOR MAKING SAME - The invention describes novel compositions and methods utilized for treating disorders and/or conditions associated with the epidermal and/or dermal level of the skin. Such disorders include hyperhidrosis, bromhidrosis, and chromhidrosis, One representative composition of the invention comprises; water, alcohol, aluminum sesquichlorohydrate, hydroxypropyl methyl cellulose, polysorbate 20, isopropyl myristate, eucalyptus oil, silicone oil, alkyl benzoate, glycerine, talc, a hydrophillic silica, a hydrophobic silica, phenoxyethanol and ethylhexyl glycerine. | 2019-04-04 |
20190099445 | A PHARMACEUTICAL OR VETERINARY COMPOSITION - The invention is directed to a pharmaceutical or veterinary composition comprising, when dissolved in a diluent, a strong ion difference in the range of 165-370 mmol/l. The invention is also directed to a pharmaceutical or veterinary composition comprising, when dissolved in a diluent, an alkalizing agent, optionally bicarbonate, in the range of 130 to 370 mmol/l. The invention is also directed to a method of treating diarrhoea in a subject, optionally a domesticated animal, the method comprising administering the aforementioned compositions. The invention is also directed to the aforementioned compositions for use in a method of treating diarrhoea in a subject, optionally a domesticated animal. | 2019-04-04 |
20190099446 | IMMUNOCOMPETENT CELL AND EXPRESSION VECTOR EXPRESSING REGULATORY FACTORS OF IMMUNE FUNCTION - It is to provide an immunocompetent cell that expresses regulatory factors of immunocompetent cell immune function and possesses all of proliferative potential, viability, and the ability to accumulate a T cell, and an expression vector of regulatory factors of immune function for generating the immunocompetent cell. An immunocompetent cell expressing a cell surface molecule specifically recognizing a cancer antigen, interleukin 7 (IL-7), and CCL19 is generated. Preferably, the cell surface molecule specifically recognizing a cancer antigen is T cell receptor specifically recognizing the cancer antigen, and the immunocompetent cell is a T cell. | 2019-04-04 |
20190099447 | ADOPTIVE CELL THERAPIES AS EARLY TREATMENT OPTIONS - Provided are methods and compositions for providing early cell therapy options to subjects, offering the potential benefit of avoiding higher risk treatment modalities. | 2019-04-04 |
20190099448 | PREPARATION OF PLATELET PELLET LYSATE AND ITS USE FOR TREATING NEUROLOGICAL DISORDERS - A process for preparing a modified heat-treated platelet pellet lysate, said process comprising the steps of: a) Providing a platelet pellet lysate, b) Heat-treating the platelet pellet lysate at a temperature of 55° C. to 65° C. during 20 to 40 minutes, c) Purifying the heat-treated platelet pellet lysate of step b) so as to obtain a modified heat treated platelet pellet lysate having a total protein content of less than 70% of the total protein content of the platelet pellet lysate of step a). | 2019-04-04 |
20190099449 | Methods of Preserving Mesenchymal Stem Cells - This disclosure relates to methods of preserving mesenchymal stromal/stem cells (MSCs) for use in clinical applications. In certain embodiments, this disclosure relates to methods of preserving MSCs comprising mixing MSCs with interferon-gamma prior to cryopreserving, freezing, or cooling the MSCs to a temperature below zero degrees Celsius. | 2019-04-04 |
20190099450 | PD-L1 EXPRESSING HEMATOPOIETIC STEM CELLS AND USES - Embodiments disclosed here provide engineered modified hematopoietic stem cells (HSCs), artificially prostaglandin E2 (PGE | 2019-04-04 |
20190099451 | RETROVIRAL CONSTRUCT HARBORING A LET-7 INSENSITIVE NUCLEIC ACID ENCODING HMGA2 AND METHODS OF USE THEREOF - A retroviral construct harboring nucleic acids encoding a high mobility group AT-hook 2 (HMGA2) protein and lacking let-7 binding sites is described as are methods of using the retroviral vector to increase the efficacy and in vivo expansion of transduced cells in gene therapy applications. | 2019-04-04 |
20190099452 | METHODS FOR PROMOTING OLIGODENDROCYTE REGENERATION AND REMYELINATION - The present invention provides a method for preventing or treating a demyelinating disease in a subject. Also provided herein is a method for reducing demyelination, inducing remyelination, promoting oligodendroglial progenitor cell (OPC) proliferation, and/or promoting oligodendrocyte differentiation in a subject. Kits are also described herein. | 2019-04-04 |
20190099453 | MEDICAMENT FOR LIVER REGENERATION AND FOR TREATMENT OF LIVER FAILURE - The present invention relates to the use of a compound which inhibits the activity of MKK4 as a medicament for the treatment of a patient suffering from an impaired liver function, to the use of a compound as a medicament for the treatment of liver failure, including acute/fulminant or chronic liver failure and/or for increasing the regeneration of liver tissue in a patient. | 2019-04-04 |
20190099454 | PROBIOTIC BACTERIA FOR THE TOPICAL TREATMENT OF SKIN DISORDERS - The present invention relates to a probiotic bacteria, and/or soluble metabolite of a probiotic bacteria and/or a cell lysate of a probiotic bacteria for use in the treatment of a disorder associated with Tight Junction function, characterised in that the probiotic bacteria, soluble metabolite of a probiotic bacteria and/or a cell lysate of a probiotic bacteria is formulated for topical administration. | 2019-04-04 |
20190099455 | COMPOSITIONS AND METHODS - Disclosed herein are therapeutic compositions containing non-pathogenic, germination-competent bacterial spores, for the prevention, control, and treatment of gastrointestinal diseases, disorders and conditions and for general nutritional health. | 2019-04-04 |
20190099456 | COMPOSITION FOR PROMOTING INTERFERON LAMBDA PRODUCTION AND PRODUCTION METHOD THEREFOR - An object of the present invention is to provide a composition for promoting interferon λ production, which contains an active ingredient exhibiting an effect of promoting interferon λ production with respect to BDCA3 DC, and a production method therefor. The present invention relates to (1) a composition for promoting interferon λ production, which contains a bacterial cell, a bacterial component, or a culture of lactic acid bacteria capable of being cultured under stress conditions, as an active ingredient, and (2) a method for producing a composition for promoting interferon λ production, which includes culturing lactic acid bacteria capable of being cultured under stress conditions so as to obtain a bacterial cell, a bacterial component, or a culture of the lactic acid bacteria. | 2019-04-04 |
20190099457 | Immunomodulatory Composition Comprising Bifidobacteria - The present invention relates to composition derivable from a bifidobacteria, methods and uses thereof, for use in modulating the immune system in a subject by affecting viral action and/or viral effects in said subject. Furthermore, said composition may also be used in reducing the risk of development and exacerbation of chronic respiratory diseases such as asthma and COPD in a subject; preferably by modulating the immune system in the subject by affecting viral action and/or viral effects in said subject. | 2019-04-04 |
20190099458 | COMPOSITIONS COMPRISING BACTERIAL STRAINS - The invention provides compositions comprising bacterial strains for treating and preventing inflammatory and autoimmune diseases. | 2019-04-04 |
20190099459 | Methods and compositions for preventing infection by a Vibrio species - Compositions and methods are provided for preventing, ameliorating, or treating a disease caused by a species of bacterial genus | 2019-04-04 |
20190099460 | Method for Treating Cancer with a Coxsackievirus B3 (CVB3) Variant - The present invention relates to a method for treating cancer in a subject in need thereof, comprising administering to said subject a therapeutically effective amount of a Coxsackie B3 group virus or a modified form thereof, wherein the cells of the cancer express a heparan sulfate (HS) receptor on their surface and the virus binds to said HS receptor, enters and accumulates in the cancer cells, whereby at least some cancer cells undergo viral lysis. | 2019-04-04 |
20190099461 | RNA VIRUSES FOR IMMUNOVIROTHERAPY - The present invention relates to a recombinant virus of the family Paramyxoviridae, comprising at least one expressible polynucleotide encoding a multispecific binding polypeptide, said multispecific binding polypeptide comprising a first binding domain binding to a surface molecule of an immune cell with antitumor activity, preferably a lymphocyte, more preferably a T cell or a dendritic cell, and a second binding domain binding to a tumor-associated antigen; to a polynucleotide encoding the same, and to a kit comprising the same. Moreover, the present invention relates to a method for treating cancer in a subject afflicted with cancer, comprising contacting said subject with a recombinant virus of the family Paramyxoviridae of the invention, and thereby, treating cancer in a subject afflicted with cancer. | 2019-04-04 |
20190099462 | Neuron activator - The present disclosure provides a neuron activator that activates neurons. The neuron activator includes at least one selected from the group consisting of a dopamine production promotor that promotes dopamine production of the neurons, a neuron extension promotor that promotes extension of the neurons, and an amyloid β resistance enhancer that enhances resistance of the neurons against amyloid β. The neuron activator includes 6-methylsulfinylhexyl isothiocyanates or glycosides thereof, and at least one selected from the group consisting of unsaturated fatty acid and polyphenol. | 2019-04-04 |
20190099463 | COMPOSITION FOR IMPROVING SLEEP ONSET AND SLEEP MAINTENANCE, COMPOSITION FOR REDUCING STRESS AND IMPROVING RELAXATION, COMPOSITION FOR IMPROVING PERFORMANCE AND CONCENTRATION, AND COMPOSITION FOR IMPROVING RESTING EFFECT AND PROMOTING RECOVERY FROM FATIGUE - [Object] To provide a composition that promotes sleep onset and sleep maintenance, reduces stress, and improves a relaxation effect, performance, concentration, a resting effect and an effect of recovery from fatigue. | 2019-04-04 |
20190099464 | SAFFRON EXTRACT AND ITS USE FOR THE PREVENTION OF MOOD DISORDERS RELATED TO DEPRESSION - The present invention relates to a powdered composition obtained from saffron stigmas characterized in that it comprises from 0.03% to 1% dry weight of safranal; and at least 3.48% dry weight of crocins that encompasses the various trans-crocin-4 (major isomer), trans-crocin-3, trans-crocin-2′, cis-crocin-4, trans-crocin-2, trans-crocin-1 isomers and any of their mixtures. | 2019-04-04 |
20190099465 | COMPOSITION FOR PREVENTING, AMELIORATING, OR TREATING HYPERURICEMIA OR METABOLIC DISORDERS RELATED WITH HYPERURICEMIA COMPRISING EXTRACT OF ALPINIA OXYPHYLLA AS EFFECTIVE INGREDIENT - The present invention relates to a composition for preventing, ameliorating, or treating hyperuricemia or metabolic disorders related with hyperuricemia comprising an extract of | 2019-04-04 |
20190099466 | PEPTIDE FOR PROMOTING WOUND HEALING, ITS COMPOSITION AND METHOD OF USING THE SAME - Disclosed is a peptide consisting of an amino acid sequence of HisThrSerThrGluAlaLys (SEQ ID NO: 1). This peptide is effective in the enhancement of fibroblast cell migration, which promotes wound healing. Also provided are a pharmaceutical composition for promoting wound healing comprising the peptide, and a method for promoting wound healing using the peptide. | 2019-04-04 |
20190099467 | METHODS AND COMPOSITIONS FOR PRESERVING RETINAL GANGLION CELLS - Provided are methods and compositions for maintaining the viability of retinal ganglion cells in a subject with an ocular disorder including, for example, glaucoma and optic nerve injury. The viability of the retinal ganglion cells can be preserved by administering a necrosis inhibitor either alone or in combination with an apoptosis inhibitor to a subject having an eye with the ocular condition. The compositions, when administered, maintain the viability of the cells and/or promote axon regeneration, thereby minimizing the loss of vision or visual function associated with the ocular disorder. | 2019-04-04 |
20190099468 | METHOD TO PROTECT AND SEAL THE OCULAR SURFACE - A method of protecting an ocular surface is provided. The method includes administering to a patient in need thereof an effective amount of a pharmaceutical composition administered in an amount effective to prevent uptake of fluorescein dye and/or rose-bengal dye. | 2019-04-04 |
20190099469 | Method For The Treatment Of Acne - Compositions and methods for the treatment of acne are disclosed herein. In one embodiment, a method for the treatment of acne includes applying a composition to the affected area, wherein the composition comprises a fermentation product derived from | 2019-04-04 |
20190099470 | MITOCHONDRIAL ANTIVIRAL-SIGNALING (MAVS) POLYPEPTIDES AND DETECTION AND USE THEREOF - The invention relates, in part, to compounds, compositions, and methods to assess characteristics of mitochondrial antiviral-signaling (MAVS) polypeptides and also to methods of modulating MAVS polypeptide characteristics. In addition, the invention relates, in part, to assays to assess characteristics of polypeptides. | 2019-04-04 |
20190099471 | METHODS FOR REDUCING SEVERITY OF PULMONARY FIBROSIS - The described invention provides a method of treating a lung injury at risk of progressing to a fibrotic lung disease in a subject in need thereof comprising administering to the subject a composition comprising a therapeutic amount of IL-6 polypeptide, hyaluronan (HA), mimetics thereof, pharmaceutically acceptable salts thereof, or combinations thereof, wherein the therapeutic amount is effective to increase renewal of alveolar epithelial cell 2 (AEC2) stem cells, to repair the injury, to reduce lung fibrosis, or a combination thereof. | 2019-04-04 |
20190099472 | USE OF GROWTH HORMONE FRAGMENTS - The invention provides a method for treating a condition in which growth hormone administration is beneficial, for treating osteoarthritis, for increasing chondrocyte, proteoglycan or collagen production or quality or repair or promoting cartilage tissue formation or repair, for promoting or improving muscle, ligament or tendon mass, repair, form or function, or for treating inflammatory, traumatic or genetic diseases of muscle or connective tissue, comprising administering to a subject an effective amount of a peptide comprising a carboxyl-terminal sequence from a growth hormone and not the IGF-1 domain of growth hormone. It also provides a method of treating a condition involving insufficient functional chondrocytes or insufficient functional cartilage tissue, the method comprising administering to a subject in need thereof a peptide comprising a carboxyl-terminal sequence from a growth hormone and not the domain of growth hormone responsible for IGF-1 production. | 2019-04-04 |
20190099473 | METHODS FOR TREATING HYPOPHOSPHATASIA IN CHILDREN - The disclosure features methods for treating hypophosphatasia (HPP) in a patient (e.g., a child having HPP) exhibiting physical impairments, disability in activities of daily living (ADL), pain, and/or delayed motor development by administering a soluble alkaline phosphatase (sALP) to the patient. | 2019-04-04 |
20190099474 | LONG LASTING EFFECT OF NEW BOTULINUM TOXIN FORMULATIONS - The invention relates to the use of an animal-protein-free botulinum toxin composition to treat a disease, disorder or condition in a patient in need thereof whereby the animal-protein-free botulinum toxin composition exhibits a longer lasting effect in the patient compared to an animal-protein-containing botulinum toxin composition. | 2019-04-04 |
20190099475 | CANCER NEOEPITOPES - Certain universal neoepitopes and cancer specific neoepitopes and methods therefor are presented that may be used in immunotherapy and cancer diagnosis. Preferred therapeutic and diagnostic compositions include antibodies or fragments thereof that bind to neoepitopes on cancer cells. | 2019-04-04 |
20190099476 | Compositions and Methods For Treating Cancer With Anti-CD22 Immunotherapy - Chimeric antigen receptors (CARs) containing CD22 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the CARs are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making CAR T cells are also disclosed. | 2019-04-04 |
20190099477 | ENGINEERING GUT COMMENSAL BACTERIA TO EXPRESS HETEROLOGOUS PROTEINS IN THEIR OUTER MEMBRANE VESICLES (OMVS) FOR DELIVERY TO THE GI-TRACT - This invention relates to the delivery of heterologous peptides or proteins such as therapeutic peptides, therapeutic proteins or antigens to mucosal sites using vesicles derived from the outer membrane of commensal bacteria, recombinant bacteria capable of producing such vesicles, and methods for the production of such vesicles. The invention further relates to an inducible expression system for use in recombinant bacteria. | 2019-04-04 |
20190099478 | Vaccines against Chlamydia sp. - The present invention describes an efficient vaccine against a | 2019-04-04 |
20190099479 | RECOMBINANT HCMV AND RHCMV VECTORS AND USES THEREOF - The present disclosure relates to recombinant rhesus cytomegalovirus (RhCMV) and human cytomegalovirus (HCMV) vectors encoding heterologous antigens, such as pathogen-specific antigens or tumor antigens, which may be used, for example, for the treatment or prevention of infectious disease or cancer. The recombinant RhCMV or HCMV vectors elicit and maintain high level cellular immune responses specific for the heterologous antigen while including deletions in one or more genes essential or augmenting for CMV replication, dissemination or spread. | 2019-04-04 |
20190099480 | A VACCINE FOR INTRADERMAL APPLICATION AGAINST PCV2 AND PRRS VIRUS INFECTION - The present invention pertains to a vaccine comprising in combination non-replicating immunogen of porcine circo virus type 2 and live attenuated PRRS virus for use in prophylactically treating an animal against an infection with porcine circovirus type 2 (PCV2) and an infection with PRRS virus by administration of the vaccine into the dermis of the animal. | 2019-04-04 |
20190099481 | ZIKA VIRUS MRNA VACCINES - Provided herein, in some embodiments, are Zika virus RNA vaccines and methods of producing an antigen-specific immune response in a subject. | 2019-04-04 |
20190099482 | LIPOSOMAL FLU VACCINE FORMULATION - The present invention relates to the field of pharmaceutical and vaccine formulations. More specifically, formulations which comprise an antigen comprising a mixture of oligopeptides loaded into liposome nanoparticles, optionally including an adjuvant, to provide an improved immune response. | 2019-04-04 |
20190099483 | Pharmaceutical composition preventing or treating an influenza viral infectious disease - The present invention provides a vaccine composition and pharmaceutical composition for preventing or treating a viral infectious disease comprising one or more selected from the group consisting of SPOCK2 protein and a gene encoding the SPOCK2 protein as an active ingredient, a method of preparing the same, and prevention and treatment method. | 2019-04-04 |
20190099484 | INFLUENZA VIRUS VACCINES AND USES THEREOF - Provided herein are chimeric influenza hemagglutinin (HA) polypeptides, compositions comprising the same, vaccines comprising the same, and methods of their use. | 2019-04-04 |
20190099485 | LYMPHANGIOGENESIS FOR THERAPEUTIC IMMUNOMODULATION - The present invention concerns methods and compositions for evoking protective immune responses against pathogen infection or cancer. In certain embodiments, the methods and compositions comprise a lymphangiogenesis inducer and an antigen. | 2019-04-04 |
20190099486 | HUMAN iNKT CELL ACTIVATION USING GLYCOLIPIDS WITH ALTERED GLYCOSYL GROUPS - Glycosphingolipids (GSLs) bearing α-glucose (α-Glc) that preferentially stimulate human invariant NKT (iNKT) cells are provided. GSLs with α-glucose (α-Glc) that exhibit stronger induction in humans (but weaker in mice) of cytokines and chemokines and expansion and/or activation of immune cells than those with α-galactose (α-Gal) are disclosed. GSLs bearing α-glucose (α-Glc) and derivatives of α-Glc with F at the 4 and/or 6 positions are provided. Methods for iNKT-independent induction of chemokines by the GSL with α-Glc and derivatives thereof are disclosed. Methods for immune stimulation in humans using GSLs with α-Glc and derivatives thereof are provided. | 2019-04-04 |
20190099487 | METHODS OF USING INTERLEUKIN-10 FOR TREATING DISEASES AND DISORDERS - Methods of modulating immune responses in subjects having oncology- and immune-related diseases, disorders and conditions by the administration of an IL-10 agent, including pegylated IL-10. | 2019-04-04 |
20190099488 | AGONIST ANTIBODIES THAT BIND HUMAN CD137 AND USES THEREOF - The present disclosure relates to compounds (e.g., antibodies, or antigen-binding fragments thereof) that bind to an epitope of CD137 and agonize CD137, and to use of the compounds in methods for treating, or ameliorating one or more symptoms of, cancer. | 2019-04-04 |
20190099489 | Novel Formulations Which Stabilize Low Dose Antibody Compositions - The present invention addresses an ongoing need in the art to improve the stability of antibody compositions. The invention broadly relates to novel formulations which stabilize and inhibit protein adsorption of low dose antibody compositions in a container means comprising a coating. More particularly, the invention described hereinafter, addresses a need in the art for formulations which stabilize and inhibit protein adsorption of low dose antibody compositions which are processed, developed, formulated, manufactured and/or stored in container means such as tormentors, bioreactors, vials, flasks, bags, syringes, rubber stoppers, tubing and the like. | 2019-04-04 |
20190099490 | APPARATUS AND METHOD FOR MAGNETIC DELIVERY OF DRUGS DEEP INTO ARTICULAR CARTILAGE FOR OSTEOARTHRITIS - Disclosed embodiments provide a tool and methodologies for delivering drugs into articular cartilage of a subject's body. | 2019-04-04 |
20190099491 | SENSITIZING CELLS TO PROTON RADIATION - Materials and methods for enhancing the effectiveness of proton radiation therapy (e.g., high linear energy transfer (LET) proton radiation therapy) against tumor cells are provided herein. | 2019-04-04 |
20190099492 | CANNABINOIDS IN COMBINATION WITH NON-CANNABINOID CHEMOTHERAPEUTIC AGENTS - The invention relates to the use of one or more cannabinoids, particularly THC and/or CBD in combination with a non-cannabinoid chemotherapeutic agent in the manufacture of a medicament for use in the treatment of cancer. In particular the cancer to be treated is a brain tumour, more particularly a glioma, more particularly still a glioblastoma multiforme (GBM). The non-cannabinoid chemotherapeutic agent may be a selective estrogen receptor modulator or an alkylating agent. | 2019-04-04 |
20190099493 | Targeting Lipids - The present invention provides targeting lipids of structure | 2019-04-04 |
20190099494 | INJECTABLE PREPARATION - An object of the present invention is to provide a storage-stable injectable preparation comprising a composition comprising a poorly soluble drug as an active ingredient and a dispersion medium. Another object of the present invention is to provide a compact, lightweight prefilled syringe by filling a syringe with the injectable preparation. The present invention provides an injectable preparation comprising a composition comprising a poorly soluble drug, a dispersion medium, and a specific suspending agent, the composition having a viscosity of 40 pascal-seconds or more in at least one point in the shear rate range of 0.01 to 0.02 s | 2019-04-04 |
20190099495 | BIODEGRADABLE DRUG DELIVERY COMPOSITIONS - A biodegradable drug delivery compositions comprising a triblock copolymer containing a polyester and a polyethylene glycol and a diblock copolymer containing a polyester and an end-capped polyethylene glycol, as well as a pharmaceutically active principle is disclosed. | 2019-04-04 |
20190099496 | Composition Intended to Vectorise an Anti-Cancer Agent - A composition in the form of a water-in-oil emulsion comprising:
| 2019-04-04 |
20190099497 | PEGYLATED GROWTH HORMONE ANTAGONISTS - A composition that is a human growth hormone receptor antagonist comprising human growth hormone receptor antagonist G120K, wherein one or two amino acids of human growth hormone receptor antagonist G120K have been mutated to cysteine; and a polyethylene glycol molecule conjugated to each substituted cysteine in the human growth hormone receptor antagonist G120K mutant. | 2019-04-04 |
20190099498 | METHODS FOR REDUCING TOXICITY OF A CHEMOTHERAPEUTIC DRUG - This disclosure relates to methods for improving the therapeutic index of a chemotherapeutic drug in the treatment of patients afflicted with cancer, by reducing chemotherapy-related toxicity to a level that allows the chemotherapeutic drug to be used in humans. | 2019-04-04 |
20190099499 | CYSTEINE ENGINEERED ANTIBODY DRUG CONJUGATES - The invention relates to polypeptides, antibodies, and antigen-binding fragments thereof, that comprise an engineered cysteine for site-specific conjugation. | 2019-04-04 |
20190099500 | ANTIBIOTIC-COATED NANOPARTICLES - Provided herein are antibiotic coated nanoparticles and methods of treating bacterial infection therewith. In particular embodiments, polymyxin B, vancomycin, and/or other antibiotics are linked to nanoparticles (e.g., gold or silica nanoparticles) and utilized for the treatment of bacterial infections. | 2019-04-04 |
20190099501 | INCLUSION COMPLEXES AND METHODS FOR MAKING THE SAME - The invention provides novel formulations comprising a stable inclusion complex of tributyrin and a cyclodextrin. In one particular embodiment, the formulation comprises an oven dried inclusion complex of tributyrin and γ-cyclodextrin that is effective in minimizing or preventing the unpleasant taste and odor of tributyrin, thus making it suitable for oral administration and delivery to the digestive tract and intestines. The invention provides compositions of these inclusion complexes and methods of using them that are advantageous as food, medicinal and other products, where the negative sensory properties of tributyrin can be a liability. | 2019-04-04 |
20190099502 | TARGETING THE NEURONAL CALCIUM SENSOR 1 FOR TREATING WOLFRAM SYNDROME - The present invention relates to novel therapeutic ways for treating Wolfram Syndrome (WS) by targeting the neuronal calcium sensor 1 (NCS1). The present inventors have demonstrated that WFS1, which loss of function is responsible of the Wolfram Syndrome, forms a complex with the neuronal calcium sensor 1 (NCS1). The inventors have further demonstrated that WFS1 associates with NCS1 to prevent its degradation by the proteasome and that NCS1 regulates VDAC expression and mitochondrial respiratory chain. Thus, present invention provides an agonist of NCS1 for use in the treatment of WS. Such an agonist is e.g. a NCS1-encoding polynucleotide, an inhibitor of the proteasome or of calpains. The inventors have further shown that overexpression of NCS1 in WS cells allows increasing complex II driven respiration. The present invention further relates to a method for predicting the severity of WS by measuring the NCS1 level in a sample obtained from a patient. | 2019-04-04 |
20190099503 | INTRATHECAL DELIVERY OF RECOMBINANT ADENO-ASSOCIATED VIRUS 9 - The present invention relates to Adeno-associated virus type 9 methods and materials useful for intrathecal delivery of polynucleotides. Use of the methods and materials is indicated, for example, for treatment of lower motor neuron diseases such as SMA and ALS as well as Pompe disease and lysosomal storage disorders. It is disclosed that administration of a non-ionic, low-osmolar contrast agent, together with a rAA9 vector for the expression of Survival Motor Neuron protein, improves the survival of SMN mutant mice as compared to the administration of the expression vector alone. | 2019-04-04 |
20190099504 | METHOD FOR DELIVERY OF BIOLOGICAL MOLECULE TO NERVOUS TISSUE - A method for delivery of a therapeutic agent to a nervous tissue. In particular, a method of delivering a therapeutic agent to a nervous tissue protected by the brain-blood barrier or meninges is disclosed. The method for delivery allows delivery of a therapeutic agent to a nervous tissue with high efficiency. In addition, the delivery method of a therapeutic agent to a nervous tissue is safe since it has lower side effects such as nervous damage than a method of administering a therapeutic agent directly to a nervous tissue. | 2019-04-04 |
20190099505 | COATED UP-CONVERSION NANOPARTICLES - The invention provides novel biocompatible upconversion nanoparticle (UCNP) that comprises a core of cubic nanocrystals (e.g., comprising α-Na Ln | 2019-04-04 |
20190099506 | METHODS AND COMPOSITIONS FOR DEUTERATED BIOLOGICS - Deuterated polymer-biomolecule conjugates and the synthesis and use of deuterated polymer-biomolecule conjugates for detecting the location of specific molecules, e.g., cell surface molecules, in a subject, and for imaging various processes within the body, for detecting the location of molecules associated with disease pathology, and for monitoring disease progression are disclosed. | 2019-04-04 |
20190099507 | HYPER-WAVE STERILIZATION CABINET - Present device is a cabinet which produces a low/no heat high energy UV beam for disinfecting heat sensitive or non-heat sensitive items. | 2019-04-04 |
20190099508 | HYPER TUMBLER - The device is a tumbler which provides a high energy UV light with low or no heat suitable for disinfecting objects, especially heat sensitive objects. | 2019-04-04 |
20190099509 | SYSTEM AND DEVICE FOR SANITIZING PERSONAL USE ITEMS - A system and apparatus for sanitizing person use items. The system is comprised essentially of a mechanism for emitting sanitizing electromagnetic radiation within an enclosed compartment. The apparatus may be light-tight such that the radiation is contained within the apparatus. It may be configured to emit a plurality of sanitizing wavelengths. The apparatus may include a series of reflective and/or refractive apparatuses to alter the reflection path of the emitted electromagnetic radiation, allowing the electromagnetic radiation to reflect in a plurality of directions. The enclosure may include a support member or personal item support that may be transparent to, or reflective of, the electromagnetic radiation. | 2019-04-04 |
20190099510 | DEODORIZING/ANTIBACTERIAL/ANTIFUNGAL AGENT, METHOD OF PREPARATION THEREOF, AND MEMBER HAVING DEODORIZING/ANTIBACTERIAL/ANTIFUNGAL AGENT ON SURFACE - A deodorizing/antibacterial/antifungal agent containing two kinds of fine particles, (i) titanium oxide fine particles and (ii) alloy fine particles containing an antibacterial/antifungal metal, gives a thin film of high transparency which has deodorizing properties and also exhibits antibacterial/antifungal properties. | 2019-04-04 |
20190099511 | COPOLYMER, WETTING AGENT, MEDICAL DEVICE, AND METHOD FOR PRODUCING SAME - Disclosed are: a polymer for treating the surface of a medical device such as a contact lens to suppress the reduction in lubricity of the device even when the device is scrubbed; a medical device having the polymer on the surface so that the reduction in lubricity over time is suppressed; and a wetting agent containing the polymer. The polymer for treating the surface is a copolymer which is water-soluble and includes as constitutional units the following monomers A and B: monomer A: a monomer containing a (meth)acryloyl group and an ester or amide structure in a molecule, in which the ester or amide structure is not constituted by including a part of the (meth)acryloyl group; monomer B: a monomer containing a (meth)acrylamide group in a molecule and having a structure different from that of the monomer A. | 2019-04-04 |
20190099512 | CHITOSAN-BASED HEMOSTATIC MEMBER FOR CERVIX AND METHOD OF MANUFACTURING THE SAME - This invention relates to a hemostatic member using chitosan having superior hemostatic activity, and more particularly to a chitosan-based hemostatic member for the cervix, suitable for use through insertion into an affected part upon cervical biopsy or surgery, configured to include a hemostatic pack having a projection at an upper end thereof through tying with a thread so as to form a spherical shape using chitosan nonwoven fabrics having a hemostatic function, wherein the thread contains an X-ray-sensitive material, thereby realizing effective hemostasis of the affected part upon cervical biopsy or surgery. | 2019-04-04 |
20190099513 | SURGICAL SUTURE MATERIALS WITH POROUS SHEATHS FOR DRUG DELIVERY - Disclosed herein are surgical suture materials that facilitate the sustained delivery of releasable components. The suture materials are processed by the disclosed methods to create a layer of pores extending inward from the outer surface of the suture. Particularly, the surgical suture materials are swollen in a calcium-ion containing solution, then freeze-dried to create pores which can be filled with a releasable component for ultimate delivery to the tissue. In one particular embodiment, the suture has an outer sheath that defines a lumen. Elongated filaments extend through the lumen. This suture embodiment is processed by the disclosed methods to yield a surgical suture material with a porous outer sheath. The pores enable efficient loading of a releasable component into the lumen, facilitating sustained delivery of the releasable component from the suture. The suture maintains its mechanical integrity despite the introduction of pores due to coordination bonds formed between the calcium ions of the swelling solution and carbonyl oxygen atoms of the polymer chains of the surgical suture material. | 2019-04-04 |
20190099514 | MULTI-PUTTY ADHESIVE AND CEMENT COMPOSITIONS FOR TISSUE HEMOSTASIS, REPAIR AND RECONSTRUCTION - The disclosure relates to polyurethane and polyureaurethane based putty compositions which harden into a fully cured solid form at room temperature and body temperature and are suitable for use as a bone cement, bone substitute, hard tissue adhesive, or bone hemostatic agent. | 2019-04-04 |
20190099515 | IMPLANTABLE FUSION DEVICES COMPRISING BIOACTIVE GLASS - Implantable devices that comprise an improved bone graft material, such as for example, bioactive glass, are disclosed. Additionally, implantable devices that work in conjunction with an improved bone graft material and act as a composite implantable device, for the improved treatment of bone, are also disclosed. These devices are bioactive, and are engineered to provide enhanced cellular activity to promote bone fusion or regrowth. | 2019-04-04 |
20190099516 | 3D PRINTED POLYVINYL ALCOHOL MEDICAL DEVICES AND METHODS OF ACTIVATION - A medical device comprising a structure formed of polyvinyl alcohol. | 2019-04-04 |
20190099517 | SKIN-ADHESIVE SILICONE GEL - Silicone gels are described that are adhesive to the skin. The gels can be used in particular for articles that are adhesive to the skin for medical or paramedical use. | 2019-04-04 |
20190099518 | Improved Biomedical Polyurethanes - The invention is directed to biomedical polyurethanes. The invention is particularly directed to biomedical polyurethanes with improved biodegradability and to an improved preparation of the biomedical polyurethanes. In particular the present invention provides a biomedical polyurethane having the formula (A-B-C-B) | 2019-04-04 |
20190099519 | METHOD FOR PRODUCING NANOSURFACES WITH NANO, MICRON, AND/OR SUBMICRON STRUCTURES ON A POLYMER - The present invention relates to a modified polymeric material. The modified polymeric material includes a polymer having a modified surface, where the modified surface includes nano, micron, and/or submicron scale features. The present invention also relates to an implant comprising the modified polymeric material. The present invention further relates to processes for making the modified polymeric material and the implant. | 2019-04-04 |
20190099520 | REINFORCED TISSUE MATRICES - Devices, methods of producing devices, and methods of treating an anatomic defect are provided. The devices and methods can include a flexible sheet of acellular tissue matrix and one or more elongated synthetic elements. The one or more synthetic elements may extend through the flexible sheet such that the one or more synthetic elements extend substantially parallel to a first top surface and a second bottom surface within one or more portions of the flexible sheet, and may be exposed on one or more portions of the first top surface of the device. | 2019-04-04 |
20190099521 | BOTTLEBRUSH POLYMER COMPOSITIONS, LUBRICATING FLUID, POROUS MATERIALS COMPRISING SAID COMPOSITIONS, AND SURFACE BEARING SAID COMPOSITIONS - A mixture of polymers with lubricating properties is provided. The polymer can be used to produce a lubricating fluid. They can also be born on a surface or embedded in a porous material. This mixture of polymers comprises (a) a pharmaceutically acceptable bottle-brush polymer comprising a backbone with polymeric pendant chains, and (b) a pharmaceutically acceptable linear polymer. In the lubricating fluid, the bottle-brush polymer and the linear polymer are dissolved together in a pharmaceutically acceptable solvent. | 2019-04-04 |
20190099522 | SURFACE TREATED BIOCOMPOSITE MATERIAL, MEDICAL IMPLANTS COMPRISING SAME AND METHODS OF TREATMENT THEREOF - Reinforced biocomposite materials having a unique treated surface, in which the surface may comprise a plurality of layers. According to at least some embodiments, medical implants are provided that incorporate novel structures, alignments, orientations and forms comprised of such reinforced bioabsorbable materials, as well as methods of treatment thereof. | 2019-04-04 |
20190099523 | FILM-FORMING COMPOSITION FOR A PH-DEPENDANT SUSTAINED RELEASE OF THE ACTIVE AGENT - The present invention discloses a liquid precursor composition adapted for application on a on a desired surface, this composition comprising: a. at least one therapeutic agent suitable for the treatment or prevention of a disorder or pathological condition, wherein said disorder or pathological condition excludes oral disorders, b. at least one acidic-pH sensitive polymer, c. at least one hydrophobic polymer, and d. a pharmaceutically acceptable volatile solvent, wherein a weight ratio between the at least one hydrophobic polymer and the at least one acidic-pH sensitive polymer is larger than 1. | 2019-04-04 |
20190099524 | MEDICAL DEVICES USING COATED POLYMERS - The present disclosure relates to medical devices using coated polymers, methods for reducing platelet attachment and/or fouling associated with medical devices, and methods for coating polymers. Certain embodiments of the present disclosure provide a medical device comprising one or more polymeric materials coated with a hyperbranched polyglycerol. | 2019-04-04 |
20190099525 | METHOD FOR PRODUCING ANTITHROMBOTIC COATING MATERIAL - Provided is a method for producing an antithrombotic coating material in which a high molecular weight polymer can be obtained by a solution polymerization using a radical polymerization initiator. The above-mentioned task is achieved by a method for producing an antithrombotic coating material, including steps of: preparing a methanol solution containing a monomer represented by formula (1): | 2019-04-04 |
20190099526 | Advanced Occlusion Management Methods for a Phacoemulsification System - The present invention provides a system for managing occlusions during phacoemulsification surgery. More specifically, the present invention provides a user of a surgical console an alert when a partial or full occlusion of a surgical tool causes the vacuum pressure to become greater than a predetermined pressure threshold setting and automatically reduces the vacuum pressure when the predetermined pressure threshold setting is exceeded. | 2019-04-04 |
20190099527 | SUBATMOSPHERIC PRESSURE MECHANISM FOR WOUND THERAPY SYSTEM AND RELATED METHODS THEREFOR - A portable system for subatmospheric pressure therapy in connection with healing a surgical wound is provided. The system includes a wound dressing dimensioned for positioning relative to a wound bed of a subject, and a collection canister in fluid communication with the wound dressing. The canister includes a base defining a fluid receiving cavity and having a fluid inlet port and a vacuum port. The fluid inlet port is configured for fluid communication with a wound dressing. The system further includes a cover selectively engageable to the base, e.g., in a snap-fit manner. The cover is configured to receive a control unit and has a vent assembly for exhausting the control unit. A seal member is interposed relative to the base and the cover to establish and maintain a substantial sealed relationship between the two components when assembled. | 2019-04-04 |
20190099528 | APPARATUS, SYSTEM AND METHOD OF PROVIDING CUSTOM VACUUM AND ASPIRATION IN A SURGICAL SYSTEM - An apparatus, system and method for providing a may include at least a phacoemulsification surgical console having a customizable non-linear custom aspiration mode. The console may include at least an aspirator; a foot pedal; and a non-transitory computing code resident on a computing memory associated with a computing processor which, when executed by the processor, causes to be executed the steps of: receiving a percentage actuation of the foot pedal; calculating, including from a non-linear algorithm, a percentage actuation for the aspirator corresponded to the received percentage foot pedal actuation; and dictating the calculated percentage aspirator actuation to the aspirator. | 2019-04-04 |