13th week of 2010 patent applcation highlights part 37 |
Patent application number | Title | Published |
20100081129 | Genemap of the human genes associated with crohn's disease - The present invention relates to the selection of a set of polymorphism markers for use in genome wide association studies based on linkage disequilibrium mapping. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility to Crohn's disease and/or their response to a particular drug or drugs. | 2010-04-01 |
20100081130 | Multifunctional particles providing cellular uptake and magnetic motor effect - Preparation of novel multifunctional particles and nanomaterials having a useful combination of magnetic and optical properties and biocompatibility. The internalization efficiencies in various in vitro cell studies have been investigated, and the external magnetic motor effect on the floating cells internalized with magnetic nanoparticles were clearly observed, for the first time. The particle surfaces can be derivatized with, for example, DNA or antibodies. The system is stable, versatile, and well-controlled. Novel gene delivery can be achieved using nanoparticles as a carrier. | 2010-04-01 |
20100081131 | IDENTIFICATION OF MICROBES USING OLIGONUCLEOTIDE BASED IN SITU HYBRIDIZATION - A method of sample analysis is provided. In certain embodiments, the method may comprise: a) contacting a sample comprising a microbe with a set of at least two labeled oligonucleotides under in situ hybridization conditions to produce a contacted sample, where the labeled oligonucleotides i. hybridize to different RNA molecules of the microbe at sites that are unique to the microbe, ii. provide a predetermined optically detectable signature that identifies the microbe when the labeled oligonucleotides are hybridized to the different RNA molecules of the microbe, and iii. do not hybridize to ribosomal RNA of the microbe; b) reading the contacted sample to detect hybridization of the labeled oligonucleotides; and c) determining the identity of the microbe on the basis of the predetermined optically detectable signal, where the predetermined optically detectable signal indicates the identity of the microbe in the sample. | 2010-04-01 |
20100081132 | BIOSENSORS AND BIOSENSING INCORPORATING RF AND MICROWAVE REDIATION - Devices capable applying microwave and RF electromagnetic radiation to specific molecular interactions between a capture molecule and a target analyte and capable of sensing the specific molecular interaction are provided. Specific molecular interactions include, for example, specific recognition events such as, receptor-ligand, antigen-antibody, DNA-protein, sugar-lectin, RNA-ribosome, and enzyme substrate interactions and nucleic acid-nucleic acid hybridizations. Additionally, methods are provided for detecting the presence or absence of a target analyte in a sample. The presence or absence of the target analyte is detected, in part, through the detection of a binding complex between the target analyte and a capture molecule in the presence of microwave and or RF electromagnetic radiation. | 2010-04-01 |
20100081133 | Methods of Detecting Root Knot Nematodes - The present invention relates to a method of testing a sample for the presence of a | 2010-04-01 |
20100081134 | BIO-BARCODE BASED DETECTION OF TARGET ANALYTES - The present invention relates to screening methods, compositions, and kits for detecting for the presence or absence of one or more target analytes, e.g. biomolecules, in a sample. In particular, the present invention relates to a method that utilizes reporter oligonucleotides as biochemical barcodes for detecting multiple protein structures or other target analytes in a solution. | 2010-04-01 |
20100081135 | Single nucleotide polymorphisms and use of same predicting male- specific prenatal loss - The present invention is directed to a panel of single nucleotide polymorphisms (SNPs) in specific genes that serve as biomarkers for sex-specific prenatal loss of a conceptus or embryo. There is provided herein methods and reagents for assessing the specific SNPs in those genes. The method useful in applying these SNPs in predicting an increased risk of prenatal loss is also disclosed. | 2010-04-01 |
20100081136 | CRTAC AS A BIOMARKER, THERAPEUTIC AND DIAGNOSTIC TARGET - The invention provides CRTAC, which is associated with cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of CRTAC as well as pharmaceutical compositions comprising such compounds. The invention also provides CRTAC as a biomarker for diseases such as cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases. | 2010-04-01 |
20100081137 | Click Chemistry for the Production of Reporter Molecules - The present invention relates to methods for producing reporter molecules suitable for the detection of analytes, e.g. nucleic acids. Further, the present invention relates to methods and regions for detecting analytes. | 2010-04-01 |
20100081138 | Nucleotide sequences for the detection of enterohaemorrhagic Escherichia coli (EHEC) - Nucleic sequences of plasmid origin are isolated from bacteria of the enterohaemorrhagic | 2010-04-01 |
20100081139 | METHOD FOR DETECTION OF PRESENCE OF TARGET POLYNUCLEOTIDE IN SAMPLES - A method for detecting the presence of a target polynucleotide in a sample, including providing a mixture of the sample and target binding agent and measuring a signal from the mixture, where the target binding agent is capable of assuming a first position where the target binding agent is not bound to the target polynucleotide and a second position where the target binding agent is bound to the target polynucleotide, and the intensity of the signal depends on the proportion of target binding agent in the first and second positions. The method is suitable for detecting a PCR product using a homogeneous detection method. | 2010-04-01 |
20100081140 | CHEMICALLY CLEAVABLE PHOSPHORAMIDITE LINKERS FOR SEQUENCING BY LIGATION - Linkers and methods for determining a nucleotide sequence of a reference oligonucleotide are provided. | 2010-04-01 |
20100081141 | Genome-Wide Chromosome Conformation Capture - The invention relates to the use of GCC (Genome Conformation Capture) technology in determining the three dimensional arrangement of an entire genome. | 2010-04-01 |
20100081142 | BIOMARKERS FOR KIDNEY DISEASES AND METHOD FOR USING SAME - The present invention provides biomarkers for detecting kidney disease, selected from the oligonucleotide sequence, complementary sequence or derivatives, amino acid sequence or derivatives, fragment, variants, antibody of annexin A2 or S100A6 or combinations thereof. Moreover, the present invention also provides an assay kit and a method for kidney disease detecting, practically for the kidney disease resulting from acute tubular necrosis. | 2010-04-01 |
20100081143 | Preparations, Compositions, and Methods for Nucleic Acid Sequencing - Preparations, compositions and methods of sequencing nucleic acids are provided. The preparations, methods and compositions employ multiple priming sites on a target nucleic acid and typically utilize single molecule sequencing processes to identify sequence portions of the target which are then assembled to obtain the sequence of the target. | 2010-04-01 |
20100081144 | POINT-OF-CARE FLUIDIC SYSTEMS AND USES THEREOF - This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications. | 2010-04-01 |
20100081145 | Detecting Prostate Cancer - Methods and kits for detecting prostate cancer in urine samples include detecting the methylation status of various genes. | 2010-04-01 |
20100081146 | METHOD OF REDUCING THE SENSITIVITY OF ASSAY DEVICES - A flow-through assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes a scavenging zone that contains a capture reagent for the analyte of interest. The capture reagent may capture a quantity of the analyte that is less than or equal to a predefined base quantity of the analyte, such as a quantity considered “normal” for a particular test sample. Thus, the capture reagent is able to prevent some of the analyte from being detected. In this manner, the sensitivity of the assay device may be reduced in a simple, inexpensive, yet effective manner. | 2010-04-01 |
20100081147 | HUMAN CATECHOL-O-METHYLTRANSFERASE (COMT) ASSAY - Disclosed is an assay (method) to quantify the amounts of catecholamine-O-methyltransferase (COMT) protein in samples, such as extracts from cell cultures, body fluids, tissues, and environmental samples. It uses novel agents (anti-NE, COMT-NE, or COMT-epitope-NE) in combination with two previously described agents (anti-COMT and COMT) in a competitive ELISA system to achieve this aim. | 2010-04-01 |
20100081149 | NOVEL OXIDIZED LDL COMPLEX AND METHOD FOR DETECTION THEREOF - Serum amyloid P component, oxidized LDL and β2-glycoprotein I can together form a complex. The presence of a disease such as hyperlipemia and atherosclerosis can be determined by detecting the complex by using either one of an anti-serum amyloid P component antibody and an anti-β2-glycoprotein I antibody. | 2010-04-01 |
20100081150 | Methods for Generating Host Cells - The present disclosure provides compositions and methods comprising cells producing glycoproteins with variant glycosylation patterns. The methods and compositions may be used in producing antibodies and proteins of therapeutic value. | 2010-04-01 |
20100081151 | BIOMARKERS FOR EARLY DETECTION OF OVARIAN CANCER - Biomarker proteins that can be used in the diagnosis of early-stage ovarian cancer (OC) are described. The biomarker panels not only permit the distinction of patients with ovarian neoplasia (benign or malignant) from normal subjects, but they also allow the identification of patients with early-stage (stage I/II) ovarian cancer from those patients with benign ovarian tumors or normal individuals. The invention additionally provides methods for detecting and treating various cancers, including cancer of the ovary using OC-related molecules. | 2010-04-01 |
20100081152 | Small Volume In Vitro Analyte Sensor and Methods of Making - A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent. | 2010-04-01 |
20100081153 | CANCER ASSOCIATED PROTEIN KINASES AND THEIR USES - Detection of expression of the provided protein kinase in cancers is useful as a diagnostic, for determining the effectiveness of drugs, and determining patient prognosis. The encoded polypeptides further provides a target for screening pharmaceutical agents effective in inhibiting the growth or metastasis of tumor cells. | 2010-04-01 |
20100081154 | IDENTIFICATION AND USE OF BACTERIAL [2Fe-2S] DIHYDROXY-ACID DEHYDRATASES - A group of bacterial dihydroxy-acid dehydratases having a [2Fe-2S] cluster was discovered. Bacterial [2Fe-2S] DHADs were expressed as heterologous proteins in bacteria and yeast cells, providing DHAD activity for conversion of 2,3-dihydroxyisovalerate to α-ketoisovalerate or 2,3-dihydroxymethylvalerate to α-ketomethylvalerate. Isobutanol and other compounds may be synthesized in pathways that include bacterial [2Fe-2S] DHAD activity. | 2010-04-01 |
20100081155 | FLUORESCENCE POLARIZATION ASSAYS FOR DETERMINING CLOSTRIDIAL TOXIN ACTIVITY - The present invention provides a method of determining the presence or activity of a clostridial toxin by (a) treating with a sample, under conditions suitable for clostridial toxin protease activity, a clostridial toxin substrate which includes a fluorophore; a bulking group; and a clostridial toxin recognition sequence containing a cleavage site that intervenes between the fluorophore and the bulking group; (b) exciting the fluorophore with plane polarized light; and (c) determining fluorescence polarization of the treated substrate relative to a control substrate, where a change in fluorescence polarization of the treated substrate as compared to fluorescence polarization of the control substrate is indicative of the presence or activity of the clostridial toxin. | 2010-04-01 |
20100081156 | FLUORESCENCE POLARIZATION ASSAYS FOR DETERMINING CLOSTRIDIAL TOXIN ACTIVITY - The present invention provides a method of determining the presence or activity of a clostridial toxin by (a) treating with a sample, under conditions suitable for clostridial toxin protease activity, a clostridial toxin substrate which includes a fluorophore; a bulking group; and a clostridial toxin recognition sequence containing a cleavage site that intervenes between the fluorophore and the bulking group; (b) exciting the fluorophore with plane polarized light; and (c) determining fluorescence polarization of the treated substrate relative to a control substrate, where a change in fluorescence polarization of the treated substrate as compared to fluorescence polarization of the control substrate is indicative of the presence or activity of the clostridial toxin. | 2010-04-01 |
20100081157 | FRET PROTEASE ASSAYS FOR CLOSTRIDIAL TOXINS - The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus toxins. A clostridial toxin substrate of the invention contains a donor fluorophore; an acceptor having an absorbance spectrum overlapping the emission spectrum of the donor fluorophore; and a clostridial toxin recognition sequence that includes a cleavage site, where the cleavage site intervenes between the donor fluorophore and the acceptor and where, under the appropriate conditions, resonance energy transfer is exhibited between the donor fluorophore and the acceptor. | 2010-04-01 |
20100081158 | FRET PROTEASE ASSAYS FOR CLOSTRIDIAL TOXINS - The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus toxins. A clostridial toxin substrate of the invention contains a donor fluorophore; an acceptor having an absorbance spectrum overlapping the emission spectrum of the donor fluorophore; and a clostridial toxin recognition sequence that includes a cleavage site, where the cleavage site intervenes between the donor fluorophore and the acceptor and where, under the appropriate conditions, resonance energy transfer is exhibited between the donor fluorophore and the acceptor. | 2010-04-01 |
20100081159 | Profiling reactive oxygen, nitrogen and halogen species - This invention provides methods, kits and systems which permit simultaneous profiling of multiple reactive oxygen species (ROS), reactive nitrogen species (RNS) and/or reactive halogen species (RHS) including reactive chlorine species (RCS) and/or reactive bromine species (RBS) through multiplexed fluorescence detection of three or more indicator probes in live cells or subcellular organelles. | 2010-04-01 |
20100081160 | Method for Diagnosing Multiple Sclerosis - Disclosed is a method for diagnosing multiple sclerosis and more particularly to a method for diagnosing multiple sclerosis by measuring levels of antibodies to glycans in a biological sample. | 2010-04-01 |
20100081161 | REAGENT FOR DILUTING BLOOD SAMPLE AND METHOD FOR MEASURING MEAN CORPUSCULAR VOLUME BY USING THE SAME - The invention provides a reagent for diluting a blood sample, comprising water, polyoxyethylene alkyl ether having a hydroxyl value of 52 to 60, and an osmo-regulator for regulating the osmotic pressure of the reagent in the range of 150 to 400 mOsm/kg, as well as a method for measuring the mean corpuscular volume of a blood sample. | 2010-04-01 |
20100081162 | METHOD OF EVALUATING ANTIWRINKLE SUBSTANCE AND METHOD OF ASSESSING THE SKIN - It is intended to provide a method whereby the skin conditions (for example, loss in the skin elasticity, wrinkle formation possibility, insufficient tightness in dermal collagen fiber bundles, or the like) can be exactly and conveniently assessed. It is also intended to provide a method whereby the wrinkle-improvement effect of a test substance can be exactly and conveniently evaluated. The skin conditions are assessed by using the expression amount of an adhesion factor in skin cells as an indication. The wrinkle reducing effect of a test substance is evaluated by using the expression amount of an adhesion factor in skin cells in the presence of the test substance as an indication. | 2010-04-01 |
20100081163 | ION CHANNEL ASSAY METHODS - A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel. | 2010-04-01 |
20100081164 | BIOCHEMICAL MARKERS FOR ACUTE PULMONARY EMBOLISM - The present invention relates to a method of differentiating between a singular and a multiple lung embolism in a subject suspected to suffer from acute lung embolism comprising determining the amount of NT-proBNP in a sample of a subject suspected to suffer from acute lung embolism and comparing the amount to a reference amount. Further, the present invention also relates to a method of differentiating between acute and chronic lung embolism in a subject comprising determining the amount of NT-proANP at a first and a second time point and comparing the determined amounts with each other. The present invention also encompasses devices and kits for carrying out the aforementioned methods. | 2010-04-01 |
20100081165 | SELF-CONTAINED BIOLOGICAL INDICATOR - The disclosed invention provides a self-contained sterilization indicator for evaluating the effectiveness of a sterilization process. The sterilization indicator includes a cap configured for housing a growth medium, the cap being mountable on a container that contains a concentration of microorganisms. The cap comprises an inner chamber for housing the growth media. The inner chamber has an opening and a breakable barrier overlying the opening for encapsulating the growth media within the inner chamber of the cap. The biological indicator is adapted for breaking the breakable barrier at a selected time to introduce the growth medium into the container such that the growth medium contacts the microorganisms. | 2010-04-01 |
20100081166 | Microbial Detection Assembly - A microbial detection assembly is disClosed which includes a tubular body, a pierceable septum, and a plunger. The tubular body defines a longitudinal axis and has a first end and a second end. The pierceable septum is configured to seal the first end of the tubular body. The plunger head is configured to substantially close the second end of the tubular body. Together, the plunger head, the pierceable septum, and the tubular body define a reservoir dimensioned to receive a medium and a sample substance. Additionally, the plunger head is positioned and is movable within the tubular body in response to changes in pressure within the reservoir. | 2010-04-01 |
20100081167 | Method and System for Pretreatment of Tissue Slides - The present invention concerns a method and an apparatus for automatic staining of at least one tissue sample accommodated on a slide by applying reagents. The system may include at least one slide provided in a slide rack, a fluid containment element, a slide holder, a vertical slide positioner to pivot the slides to a vertical position, and a slide immerser element to immerse the vertical slide into a fluid containment element or even a dip tank. By pivoting the slides from a horizontal to a vertical position, an automated method and apparatus for carrying out a pretreatment in an automated staining apparatus may be provided. The pivoting of slides may ensure an appropriate orientation of the slides for both the pretreatment and the staining processes. | 2010-04-01 |
20100081168 | Use of Acid Stable Protease in Animal Feed - The present invention relates to acid-stable proteases homologous to those derived from strains of the genus | 2010-04-01 |
20100081169 | PRODUCTION OF A LIPID ACYLTRANSFERASE FROM TRANSFORMED BACILLUS LICHENIFORMIS CELLS - The present invention relates to a method for the production of a lipid acyltransferase comprising the steps of: (i) providing a | 2010-04-01 |
20100081170 | METHODS FOR PRODUCING SOLUBLE MEMBRANE-SPANNING PROTEINS - Methods for producing membrane-spanning polypeptides in high yields, with native conformation, and/or in soluble form include solubilizing in non-ionic or zwitterionic detergents, as well as use of promoters and expression vectors for expressing high yields of membrane-spanning polypeptides in bacterial cells. Mutated promoters provide tight control of membrane-spanning polypeptides in bacterial cell hosts. | 2010-04-01 |
20100081171 | METHOD FOR LYOPHILIZING COMPETENT CELLS - This invention relates to a method for producing cells which are competent for transformation and which may be stably stored for extended periods of time at various temperatures. The method involves growing cells in a growth conducive medium, rendering said cells competent, and lyophilizing said competent cells. The invention further relates to competent cells produced by such a method, to methods of transforming said cells with a DNA molecule, and to a method of producing a desired protein or polypeptide from said transformed cells. | 2010-04-01 |
20100081172 | N-Glycans and Uses Thereof - The present disclosure provides compositions and methods comprising cells producing glycoproteins with variant glycosylation patterns. The methods and compositions may be used in producing antibodies and proteins of therapeutic value. | 2010-04-01 |
20100081173 | Microorganism Producing Inosine and Method of Producing Inosine Using the Same - The present invention relates to a microorganism producing inosine, which is one of purine nucleoside, an important material for 5′-inosinic acid synthesis, and method for producing inosine using the same. More particularly, the present invention relates to a recombinant microorganism of | 2010-04-01 |
20100081174 | Methods for Detection of Methyl-CpG Dinucleotides - The invention provides methods for enriching methyl-CpG sequences from a DNA sample. The method makes use of conversion of cytosine residues to uracil under conditions in which methyl-cytosine residues are preserved. Additional methods of the invention enable to preservation of the context of me-CpG dinucleotides. The invention also provides a recombinant, full length and substantially pure McrA protein (rMcrA) for binding and isolation of DNA fragments containing the sequence 5′-C | 2010-04-01 |
20100081175 | ENZYME-CONTAINING GELS AND NUCLEIC ACID AMPLIFYING KITS - The present invention is aimed at providing an enzyme-containing gel which is employed for deactivating, from a sample containing proteins and nucleic acids, easily and simply the proteins in the sample and then amplifying a nucleic acid in the sample, a kit for the amplification of nucleic acid which comprises the enzyme-containing gels, and a method for the amplification of nucleic acid which employs the enzyme-containing gels. The present invention provides an enzyme-containing gel which is characterized in that the gel contains a heat-resistant enzyme; a kit for the amplification of nucleic acid, comprising the above-described enzyme-containing gels and a proteolytic enzyme; and a method for the amplification of nucleic acid, employing the above-described enzyme-containing gels. | 2010-04-01 |
20100081176 | ENZYME-CONTAINING CAPSULES AND NUCLEIC ACID AMPLIFICATION KITS - An object of the present invention is to provide an enzyme-containing capsule which is employed for deactivating, from a sample, the proteins in the sample and then amplifying a nucleic acid in the sample, a kit for the amplification of nucleic acid which comprises the enzyme-containing capsules, and a method for the amplification of nucleic acid which employs the enzyme-containing capsules. The present invention provides an enzyme-containing capsule which is characterized in that the capsule has a melting point of 60 to 95° C., comprises a non-proteinous material as the envelope component, and contains a heat-resistant enzyme in the inside of the capsule; a kit for the amplification of nucleic acid, comprising the above-described enzyme-containing capsules and a proteolytic enzyme; and a method for the amplification of nucleic acid, employing the above-described enzyme-containing capsules. | 2010-04-01 |
20100081177 | Decreasing RUBISCO content of algae and cyanobacteria cultivated in high carbon dioxide - Algae and cyanobacteria are genetically engineered to have lower RUBISCO (ribulose-1,5-bisphosphate carboxylase/oxygenase) content in order to grow more efficiently at elevated carbon dioxide levels while recycling industrial CO | 2010-04-01 |
20100081178 | MODIFIED PHOTOSYNTHETIC MICROORGANISMS FOR PRODUCING TRIGLYCERIDES - This disclosure describes genetically modified photosynthetic microorganisms, including Cyanobacteria, that contain one or more exogenous genes encoding a diacylglycerol acyltransferase, a phosphatidate phosphatase, and/or an acetyl-CoA carboxylase, and which are capable of producing increased amounts of fatty acids and/or synthesizing triglycerides. | 2010-04-01 |
20100081179 | INCREASED HETEROLOGOUS Fe-S ENZYME ACTIVITY IN YEAST - Yeast strains were engineered that have increased activity of heterologous proteins that require binding of an Fe—S cluster for their activity. The yeast strains have reduced activity of an endogenous Fe—S protein. Activities of heterologous fungal or plant 2Fe-2S dihydroxy-acid dehydratases and Fe—S propanediol dehydratase reactivase were increased for increased production of products made using biosynthetic pathways including these enzymes, such as valine, isoleucine, leucine, pantothenic acid (vitamin B5), isobutanol, 2-butanone and 2-butanol. | 2010-04-01 |
20100081180 | METHOD FOR PRODUCING AN ORGANIC ACID - An organic acid is produced by allowing a bacterium which has an ability to produce an organic acid and has been modified so that expression of yidE gene is enhanced, or a product obtained by processing the bacterium, to act on an organic raw material in a reaction mixture containing carbonate ions, bicarbonate ions, or carbon dioxide gas to produce the organic acid, and collecting the organic acid. | 2010-04-01 |
20100081181 | METHOD FOR CONVERSION OF OIL-CONTAINING ALGAE TO 1,3-PROPANEDIOL - The present invention relates to a process for oxidizing renewable polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) to a malonic acid intermediate which is subsequently reduced to 1,3 propanediol (PDO). | 2010-04-01 |
20100081182 | ENHANCED IRON-SULFUR CLUSTER FORMATION FOR INCREASED DIHYDROXY-ACID DEHYDRATASE ACTIVITY IN LACTIC ACID BACTERIA - Lactic acid bacteria expressing dihydroxyacid dehydratase polypeptides with increased specific activity are disclosed. The lactic acid bacteria comprise recombinant genes encoding iron-sulfur cluster forming proteins. | 2010-04-01 |
20100081183 | ENHANCED DIHYDROXY-ACID DEHYDRATASE ACTIVITY IN LACTIC ACID BACTERIA - Lactic acid bacterial (LAB) cells were modified such that they have a specific activity of dihydroxy-acid dehydratase enzyme activity that is increased to about 0.1 μmol min | 2010-04-01 |
20100081184 | METHOD FOR EVALUATION, DESIGN AND OPTIMIZATION OF IN-SITU BIOCONVERSION PROCESSES - A method for the evaluation, design and optimization of in-situ bioconversion processes for the conversion of carbon to methane and other useful gases and liquids. The method utilizes a comprehensive computer simulation model for accurately simulating the physical and dynamic conditions in a subterranean carbon-bearing formation and the effects of stimulating the growth of indigenous or non-indigenous microbes therein for the bioconverstion of carbon to methane and other useful gases and liquids. The method enables the prediction of bioconversion rates and efficiencies under a range of variables, and thus provides for the optimization of in-situ bioconversion process design and operation. | 2010-04-01 |
20100081185 | System and method for photodynamic cell therapy - The invention can be characterized as method for stimulating or inhibiting gene expression by photomodulating living cells using a source of narrowband multichromatic electromagnetic radiation. The cells may include, among others, nerve cells, skin cells, retinal cells, heart cells, stem cells, brain cells, cells found in human organs, cells found in hair follicles, and cells found in the human eye or retina. Photomodulation may be enhanced using topically or orally administered compositions. The source of narrowband multichromatic electromagnetic radiation may include at least one light emitting diode (LED) that can emit radiation having a wavelength of from about 300 nm to about 1600 nm. | 2010-04-01 |
20100081186 | Self-decontaminating metal organic frameworks - A self-decontaminating metal organic framework including an acid linked to a metal producing a metal organic framework configured for the sorption of chemical warfare agents and/or toxic industrial chemicals, the metal organic framework including reactive sites for the degradation of the agents and chemicals. | 2010-04-01 |
20100081187 | RECOMBINANT VITAMIN K DEPENDENT PROTEINS WITH HIGH SIALIC ACID CONTENT AND METHODS OF PREPARING SAME - Methods of isolating highly sialylated recombinant vitamin K dependent proteins, particularly Factor IX, by chromatographic methods are described. The highly sialylated recombinant proteins are characterized. The improved Factor IX has at least 62% N-glycosylation with 3 or 4 sialic acid residues and improved bioavailability and pharmokinetic properties. | 2010-04-01 |
20100081188 | APPARATUS FOR DETECTING DRUGS IN A BEVERAGE - A test kit for detecting the presence of one or more drugs in a beverage comprising a support having a plurality of detector strips attached thereto. Drugs to be detected are e.g. benzodiazepines, gamma hydroxy butyrate (GHB), Ketamines, Ectasy (MDMA), cocaine barbiturates, opiates, cannabis and flunitrazepam (Rohypnol®). | 2010-04-01 |
20100081189 | Sample Chamber - The invention relates to a sample chamber for testing samples, comprising a bottom plate and a cover plate connected thereto, a sample reservoir for receiving a liquid and/or a sample to be tested, and a contact electrode which is arranged entirely in the bottom plate, in the cover plate or between the bottom plate and the cover plate and which is electrically conductively connected to a conductor element or semiconductor element disposed in and/or on the sample chamber, wherein the bottom plate and/or the cover plate are designed in such a way that an electrical contact with the contact electrode can be established from the outside in such a way that an electrically conductive connection to the conductor element or to the semiconductor element can be established from the outside through the bottom plate or through the cover plate via the contact electrode. | 2010-04-01 |
20100081190 | Histological facilitation systems and methods - Systems, methods, and other modalities are described for generating or otherwise handling images or other data indicating (a) an extraction of chemically treated tissue frozen in vivo, (b) a treatment of a tissue sample in a chamber extended into tissue of an organism, and/or (c) cells to which an optical enhancement material was applied in vivo. Several contexts in which such indications facilitate histological evaluation are likewise described. | 2010-04-01 |
20100081191 | ANISOTROPIC HEAT SPREADER FOR USE WITH A THERMOELECTRIC DEVICE - A well block for use with a Polymerase Chain Reaction (PCR) Cycler may include a body for holding a plurality of specimen vials, a base for attaching the well block to a temperature control device, and a temperature plate coupled to the base. Further, the temperature plate may include an anisotropic material for transferring thermal energy between the body and the temperature control device. | 2010-04-01 |
20100081192 | EARLY PROSTATE CANCER ANTIGENS (EPCA), POLYNUCLEOTIDE SEQUENCES ENCODING THEM, AND THEIR USE - A novel prostate cancer marker is described that is found in cancerous and normal prostate cells of individuals that have prostate cancer but is not found in the prostate of individuals without prostate cancer. The marker also is present in normal tissue adjacent to tumor tissue in individuals having prostate cancer. The marker, however, is absent in the prostate of individuals without prostate cancer. Methods employing the novel prostate cancer marker of the invention to predict the occurrence of the prostate disease, monitor the progression of prostate cancer and effect the treatment of prostate cancer, also are described. | 2010-04-01 |
20100081193 | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis - Isolated polynucleotide sequences exhibiting endothelial cell specific promoter activity, novel cis regulatory elements and methods of use thereof enabling treatment of diseases characterized by aberrant neovascularization or cell growth are disclosed. | 2010-04-01 |
20100081194 | CELLS HAVING CARDIAC GLYCOSIDE RESISTANCE - A recombinant Na+, K+-ATPase α1-subunit protein resistant to cardiac glycosides, e.g. oubain, is disclosed, as well as methods for its production and use. The resistance to cardiac glycosides are obtained by alterations in the region situated between and including the amino acids 65-133. Such recombinant protein and nucleic acid constructs expressing the same are useful as selection markers in gene therapy and research applications. | 2010-04-01 |
20100081195 | Modified Host Cells and Uses Thereof - The present disclosure provides compositions and methods comprising cells producing glycoproteins with variant glycosylation patterns. The methods and compositions may be used in producing antibodies and proteins of therapeutic value. | 2010-04-01 |
20100081196 | Method for Separating a Volume of Whole Blood Into At Least Three Components - A method for separating a volume of whole blood contained in a separation bag into at least three components comprising centrifuging the separation bag so as to separate therein a first inner layer comprising plasma, a second intermediate layer comprising platelets, a third intermediate layer comprising lymphocytes, monocytes and granulocytes and a fourth outer layer comprising red blood cells, transferring, into a plasma component bag connected to the separation bag, a plasma component and transferring into a mononuclear cell component bag a mononuclear cell components. | 2010-04-01 |
20100081197 | In vivo modulation of neuronal transport - A method for visualizing an active synapse wherein said method comprises: (a) exposing cells forming the active synapse to a biomarker comprising at least fragment C of tetanus toxin and a reporter protein; and (b) visualizing the biomarker; wherein the accumulation of the biomarker into dendritic spines of the cells allows visualization of an active synapse. Also, a method for screening molecules capable of modulating synapse activity is provided. A kit useful for the early diagnosis of neurodegenerative disease comprises a biomarker comprising at least fragment C of tetanus toxin and a reporter protein. | 2010-04-01 |
20100081198 | METHOD FOR THE REPAIR OF MUTATED RNA FROM GENETICALLY DEFECTIVE DNA AND FOR THE SPECIFIC DESTRUCTION OF TUMOR CELLS BY RNA TRANS-SPLICING, AND A METHOD FOR THE DETECTION OF NATURALLY TRANS-SPLICED CELLULAR RNA - Methods and products for the repair of genetically defective DNA in the region of a mutated exon, for the specific destruction of tumor cells, and for the identification of naturally trans-spliced RNA. The methods inter alia are based on the utilization of cellular RNA splicing components. | 2010-04-01 |
20100081199 | Generation of mature myelomonocytic cells through expansion and differentiation of pluripotent stem cell-derived lin-CD34+CD43+CD45+progenitors - A method for efficient generation of neutrophils, eosinophils, macrophages, osteoclasts, dendritic cells an Langerhans cells from human embryonic stem cells is disclosed. | 2010-04-01 |
20100081200 | FORMULATIONS AND METHODS FOR CULTURING STEM CELLS - The present invention relates to a serum replacement formulation and to a culture medium suitable for the derivation, maintenance and differentiation of stem cells. | 2010-04-01 |
20100081201 | Olig1 mini-promoters - Isolated polynucleotides comprising an OLIG1 promoter are provided, where an OLIG1 regulatory element is operably joined to an OLIG1 basal promoter utilizing a non-native spacing between the promoter and regulatory elements. The promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, etc. | 2010-04-01 |
20100081202 | PROCESS FOR FACILITATING NUCLEIC ACID TRANSFER - Means for transferring efficiently a desired nucleic acid into a cell is provided. | 2010-04-01 |
20100081203 | FLUORESCENT ISOTOPE TAGS AND THEIR METHOD OF USE - The present invention provides novel reactive fluorescent compounds that incorporate stable isotopic (deuterium, 13-carbon, 15-nitrogen, 18-oxygen) substitutions. The invention includes the use of these compounds, in combination with non-isotopically substituted analogs, for the purification, identification and relative quantification of proteins, peptides, saccharides, metabolites, and other biologically important compounds by combining liquid chromatography (LC) and mass spectrometry (MS). Fluorescent labeling of target compounds in this manner provides orders-of-magnitude sensitivity enhancement over traditional stable isotope labels, and also affords the possibility of simultaneous multiplexed analysis due to the multiwavelength nature of different fluorophores. | 2010-04-01 |
20100081204 | NUCELIC-ACID-RESPONSIVE GEL, METHOD FOR PRODUCING SAME, AND USE OF SAME - The present invention provides a nucleic-acid-responsive gel which allows (i) a larger volumetric change through structural design, (ii) adjustment of its recognition ability to recognize a nucleic acid, (iii) improvement of sensitivity, and (iv) flexible design according to, e.g., a sequence of target DNA. The nucleic-acid-responsive gel includes a probe formed of two single-stranded nucleic acids which are hybridized with each other. The probe is fixed within a network structure of a polymer gel. The two single-stranded nucleic acids are bound reversibly with each other. | 2010-04-01 |
20100081205 | FLUOROPHORE EMBEDDED/INCORPORATING/BRIDGED PERIODIC MESOPOROUS ORGANOSILICAS AS RECOGNITION ELEMENTS FOR OPTICAL SENSORS - Periodic mesoporous organosilicas (PMO) which incorporate an optically active molecule into the material for use as an optical indicator of target binding. This material combines the stability, selectivity, and high density of binding sites characteristic of the PMO with the sensitivity and selectivity of the optically active molecule. The material undergoes a change when exposed to a sample containing a target molecule. The change can be observed by visual inspection or through the use of fluorescence spectra. | 2010-04-01 |
20100081206 | PASSIVE IN-SITU CHEMICAL SENSOR - A chemical sensor for assessing a chemical of interest. In typical embodiments the chemical sensor includes a first thermocouple and second thermocouple. A reactive component is typically disposed proximal to the second thermal couple, and is selected to react with the chemical of interest and generate a temperature variation that may be detected by a comparison of a temperature sensed by the second thermocouple compared with a concurrent temperature detected by the first thermocouple. Further disclosed is a method for assessing a chemical of interest and a method for identifying a reaction temperature for a chemical of interest in a system. | 2010-04-01 |
20100081207 | ASSAY MATERIAL, METHOD OF DETECTING A TARGET USING THE SAME, AND METHOD OF PRODUCING THE SAME - One or more exemplary embodiments providing an assay material including an assay material that includes a substrate, a compound linked to the substrate wherein the compound is linkable specifically to a target, and a patterned region disposed on the substrate wherein the patterned region provides an optical output signal when an incident optical signal is irradiated thereto and wherein the optical output signal corresponds to a code on the substrate. | 2010-04-01 |
20100081208 | Multirange indicator - A multirange indicator is proposed which permits quantitative dose determination of high-energy actinic radiation, where the dose for different wavelength ranges can be respectively determined in parallel. To this end, the multirange indicator has two indicator systems designed with mutually corresponding properties, thus eliminating any mutual distortion of the results of the dose measurements. The first indicator system is based on a photolatent Lewis acid or photolatent Lewis base, and the second indicator system is based on a polysubstituted triphenylmethane dye. Both the multirange indicator and its use for the production of various dose-measurement devices are described. Finally, the following are proposed for the measurement of UV radiation and/or electron-beam radiation: as dose-measurement device, a dose-measurement coating material and a flat dose-measurement element, these being based on the above multirange indicator, and also the measurement method that can be implemented with the said dose-measurement devices. | 2010-04-01 |
20100081209 | PIPETTE TIPS FOR EXTRACTION, SAMPLE COLLECTION AND SAMPLE CLEANUP AND METHODS FOR THEIR USE - The present invention is a pipette tip device for extraction of liquid, semi-solid or solid solutions to be chemically analyzed and the methods for their use. The pipette tip extraction device contains a screen or filter at its lower narrow end to contain solid particulate matter and a barrier at its upper wide end. The optional upper frit is to be made of material that permits liquid solutions to flow through it. In addition to the barrier and screen, the pipette tip extraction device may contain solid-phase sorbent. Through the use of a removable cap, the pipette extraction tip may also serve as a sample collection container or tip in which samples can be delivered to the top of the tip (e.g., for direct collection of samples, including solid samples). A new method for DPX extraction using liquid-liquid-solid-phase extraction is also disclosed. | 2010-04-01 |
20100081210 | REACTION METHOD AND REACTION APPARATUS - A reaction method of performing an adsorption reaction in which a subject substance of analysis is specifically adsorbed in a first channel, the method includes: flowing a specimen liquid to a second channel connected to the first channel so that the specimen liquid is fed to the first channel, the specimen liquid containing the subject substance and a labeled substance that can be bonded to the subject substance; stopping feeding of the specimen liquid by detecting an event that a rear end of the specimen liquid flows into the first channel; joining a washing liquid to the rear end of the specimen liquid which stops in the first channel by flowing the washing liquid to a third channel that is converged to a connection portion of the second channel; and feeding the washing liquid to the first channel after the washing liquid is joined to the rear end. | 2010-04-01 |
20100081211 | LUMINESCENT LANTHANIDE LABELLING REAGENTS AND THEIR USE - The invention relates to a detectable molecule comprising a biospecific binding reactant attached to a luminescent lanthanide chelate comprising a lanthanide ion and a chelating ligand of the formula (I) | 2010-04-01 |
20100081212 | ANTIBODIES FOR DETERMINING THE PROTHROMBIN FRAGMENT F2/F1+2 IN A HOMOGENEOUS IMMUNOASSAY - The present invention is in the area of coagulation analysis and relates to antibodies which bind specifically to an immune complex of prothrombin fragment F2/F1+2 and an F2/F1+2 neoepitope-specific antibody fragment, and to the preparation and the use thereof in methods for determining F2/F1+2. | 2010-04-01 |
20100081213 | CENTRIFUGAL-BASED MICROFLUIDIC APPARATUS, METHOD OF FABRICATING THE SAME, AND METHOD OF TESTING SAMPLES USING THE MICROFLUIDIC APPARATUS - Provided is a microfluidic apparatus including: a microfluidic structure for providing spaces for receiving a fluid and for forming channels, through which the fluid flows; and valves for controlling the flow of fluid through the channels in the microfluidic apparatus. The microfluidic structure includes: a sample chamber; a sample separation unit receiving the sample from the sample chamber and separating a supernatant from the sample by using a centrifugal force; a testing unit receiving the supernatant from the sample separation unit for detecting a specimen from the supernatant using an antigen-antibody reaction, and a quality control chamber for identifying reliability of the test. | 2010-04-01 |
20100081214 | CHROMATOGRAPHIC ASSAY SYSTEM - The present application discloses an analyte detection apparatus having at least one reservoir area and a wicking membrane, wherein a labeled specific binding partner is impregnated on the reservoir area; and a region on the wicking membrane where at least one chemical component is immobilized. | 2010-04-01 |
20100081215 | COATING FOR MICROCARRIERS - The present invention relates to carriers, which are coated by at least one layer of polyelectrolytes and one layer of magnetic material. These carriers can be manipulated in a magnetic field. The application of the coating of the present invention on microcarriers comprising a fluorescent core results in a carrier with a homogeneous luminescence. Additionally, where the core is provided with a code, this allows improved reading thereof. | 2010-04-01 |
20100081216 | METHOD AND DEVICE FOR RAPID PARALLEL MICROFLUIDIC MOLECULAR AFFINITY ASSAYS - Disclosed are methods and devices for rapid parallel molecular affinity assays performed in a microfluidic environment. The invention exploits hydrodynamic addressing to provide simultaneous performance of multiple assays in parallel using a minimal sample volume flowing through a single channel. | 2010-04-01 |
20100081217 | DEFECT INSPECTION APPARATUS, DEFECT INSPECTION METHOD, AND SEMICONDUCTOR DEVICE MANUFACTURING METHOD - A defect inspection method includes generating and applies a charged beam to a sample with patterns; controlling a shape of the charged beam so that a beam width in a first direction perpendicular to an optical axis differs from a beam width in a second direction perpendicular to the optical axis and the first direction, while substantially maintaining a cross-sectional area of the beam; scanning the sample with the charged beam having the controlled shape; and detecting charged particles from the sample by irradiation of the charged beam and detects a defect of the patterns. Assuming that the beam width of the charged beam in the first direction is smaller than that in the second direction, the first direction is set to a direction in which an interval between adjacent patterns becomes a minimum value and the sample is scanned in the second direction. | 2010-04-01 |
20100081218 | Forming Light Emitting Devices Including Custom Wavelength Conversion Structures - Methods of forming a light emitting device include selectively forming a wavelength conversion structure on a light emitting element using stereolithography. Selectively forming the wavelength conversion structure may include covering the light emitting element with a photo-curable liquid polymer containing a luminescent material, and exposing the liquid polymer to light for a time sufficient to at least partially cure the liquid polymer. Multiple layers of polymer can be selectively built up to form a wavelength conversion structure having a custom shape on the light emitting element. | 2010-04-01 |
20100081219 | METHOD OF MANUFACTURING A SEMICONDUCTOR DEVICE - In the method of manufacturing a semiconductor device, first, values of diffusion parameters of a semiconductor device are acquired in a middle of manufacturing the semiconductor device. Next, a target value of another diffusion parameter to be determined by a processing implemented in a subsequent process of the semiconductor device manufacturing process is calculated. The another diffusion parameter is calculated by substituting the acquired values of diffusion parameters and a desired value of an electrical characteristic of the semiconductor device into a predetermined prediction expression. The prediction expression is an expression showing a corresponding relationship between the electrical characteristic and a plurality of types of diffusion parameters of the semiconductor device. Subsequently, processing conditions for the processing implemented in the subsequent process to realize the target value is determined. Then, the processing to the semiconductor device in the subsequent process is implemented under the determined processing conditions. | 2010-04-01 |
20100081220 | METHOD FOR MANUFACTURING LIGHT-EMITTING DIODE - The present invention relates to a light-emitting diode (LED) and a method for manufacturing the same. The LED comprises an LED die, one or more metal pads, and a fluorescent layer. The characteristics of the present invention include that the metals pads are left exposed for the convenience of subsequent wiring and packaging processes. In addition, the LED provided by the present invention is a single light-mixing chip, which can be packaged directly without the need of coating fluorescent powders on the packaging glue. Because the fluorescent layer and the packaging glue are not processed simultaneously and are of different materials, the stress problem in the packaged LED can be reduced effectively. | 2010-04-01 |
20100081221 | SEMICONDUCTOR LIGHT EMITTING DEVICE HAVING TEXTURED STRUCTURE AND METHOD OF MANUFACTURING THE SAME - A semiconductor light emitting diode having a textured structure and a method of manufacturing the same are provided. The semiconductor light emitting diode includes a first semiconductor layer formed into a textured structure, an intermediate layer formed between the textured structures of the patterned first semiconductor layer, and a second semiconductor layer, an active layer, and a third semiconductor layer sequentially formed on the first semiconductor layer and the intermediate layer. | 2010-04-01 |
20100081222 | Array substrate for a liquid crystal display device having multi-layered metal line and fabricating method thereof - An array substrate for a liquid crystal display device includes: a substrate; a gate electrode and a gate line on the substrate; a gate insulating layer on the gate electrode and the gate line; an active layer on the gate insulating layer; an ohmic contact layer on the active layer; source and drain electrodes and a data line on the ohmic contact layer, the source and drain electrodes and the data line having a multiple metal layer; a passivation layer on the source and drain electrodes and the data line; and a pixel electrode on the passivation layer. | 2010-04-01 |
20100081223 | ARRAY SUBSTRATE FOR A REFLECTIVE LIQUID CRYSTAL DISPLAY DEVICE AND MANUFACTURING METHOD FOR THE SAME - An array substrate of a reflective liquid crystal display device including gate and data lines on the substrate, a thin film transistor adjacent to where a gate line and a data line cross over each other, wherein the thin film transistor has a gate electrode, a source electrode and a drain electrode, a passivation layer with an uneven surface having curved profiles that are asymmetric over the thin film transistor, and an opaque conductive pixel electrode having a reflective surface with curved profiles that are asymmetric on the passivation layer. | 2010-04-01 |
20100081224 | METHOD OF FORMING DIFFRACTION GRATING AND METHOD OF FABRICATING DISTRIBUTED FEEDBACK LASER DIODE - A method of forming a diffraction grating according to the present invention includes a step of preparing a mold having projections and recesses for forming a diffraction grating, a step of bringing the projections and recesses of the mold into contact with a resin layer in a chamber at a first pressure less than atmospheric pressure, a step of setting a pressure in the chamber to a second pressure more than the first pressure while maintaining the contact, and a step of hardening the resin layer while maintaining the contact between the resin layer and the projections and recesses so as to form a pattern for the diffraction grating on the hardened resin layer. The recesses in the projections and recesses of the mold form a closed pattern in the plane of the mold including the projections and recesses. | 2010-04-01 |
20100081225 | MASK PATTERN FOR SELECTIVE AREA GROWTH OF SEMICONDUCTOR LAYER AND SELECTIVE AREA GROWTH METHOD USING THE MASK PATTERN FOR SEMICONDUCTOR LAYER - Provided is a mask pattern for selective area growth of a semiconductor layer and a selective area growth method for a semiconductor layer for independently controlling a growth rate and a strain of the semiconductor layer. The selective area growth method includes: forming a plurality of pairs of first mask patterns, the first mask patterns in each pair including a first open area therebetween, the first open area having a width that is wider than a distance causing overgrowth of the semiconductor layer, the pairs of the first mask patterns repeatedly arranged with a period P therebetween; wherein controlling a growth rate and a strain of the semiconductor layer formed on the first open area by adjusting the period P. | 2010-04-01 |
20100081226 | A METHOD OF GROWING SEMICONDUCTOR HETEROSTRUCTURES BASED ON GALLIUM NITRIDE - The method of growing non-polar epitaxial heterostructures for light-emitting diodes producing white emission and lasers, on the basis of compounds and alloys in AlGaInN system, comprising the step of vapor-phase deposition of one or multiple heterostructures layers described by the formula Al | 2010-04-01 |
20100081227 | Luminous device and method of manufacturing the same - A luminous device and a method of manufacturing the luminous device are provided. The luminous device includes a light emitting layer and first and second electrodes connected to the light emitting layer. The light emitting layer is a strained nanowire. | 2010-04-01 |
20100081228 | NANOSTRUCTURED QUANTUM DOTS OR DASHES IN PHOTOVOLTAIC DEVICES AND METHODS THEREOF - A photovoltaic device includes one or more structures, an array of at least one of quantum dots and quantum dashes, at least one groove, and at least one conductor. Each of the structures comprises an intrinsic layer on one of an n type layer and a p type layer and the other one of the n type layer and the p type layer on the intrinsic layer. The array of at least one of quantum dots and quantum dashes is located in the intrinsic layer in at least one of the structures. The groove extends into at least one of the structures and the conductor is located along at least a portion of the groove. | 2010-04-01 |
20100081229 | METHOD OF ASSEMBLING INTEGRATED CIRCUIT COMPONENTS - The disclosure identified as methods of mounting integrated circuits, including solar cells, to a substrate wherein the circuits are mounted prior to being singulated into discrete die. Once the semiconductor die sites or other circuits are formed on a wafer, the wafer will be attached, either whole, or divided into one or more multi-die site wafer segments, to a substrate. This attachment may be by conventional surface mount technology, for example. After such mounting, the individual die sites on the wafer segments will be singulated to form discrete die already mounted to the supporting substrate. The singulation may be preferably performed by laser dicing of the wafer segments. | 2010-04-01 |