13th week of 2022 patent applcation highlights part 12 |
Patent application number | Title | Published |
20220096626 | HUMAN CYTOMEGALOVIRUS VACCINE - The disclosure relates to HCMV ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines. | 2022-03-31 |
20220096627 | COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTIONS THROUGH STIMULATED INNATE IMMUNITY IN COMBINATION WITH ANTIVIRAL COMPOUNDS - Embodiments are directed to compositions and methods for treating viral infections. | 2022-03-31 |
20220096628 | IMMUNOTHERAPEUTIC CONSTRUCTS AND METHODS OF THEIR USE - Disclosed herein are immunotherapeutic constructs comprising a delivery particle, at least one adjuvant, and one or more therapeutic agents/compounds that cause antigen release and/or modulate immunosuppressive tumor microenvironment. These immunotherapeutic constructs create adaptive immunity or anti-cancer immune response(s) that can be used, for instance, to prevent and treat broad types of cancer. Further disclosed are uses of the immunotherapeutic constructs, including to prevent and treat cancer in humans and animals. | 2022-03-31 |
20220096629 | METHODS OF DISEASE ACTIVITY PROFILING FOR PERSONALIZED THERAPY MANAGEMENT - The present invention provides methods for personalized therapeutic management of a disease in order to optimize therapy and/or monitor therapeutic efficacy. In particular, the present invention comprises measuring an array of one or a plurality of biomarkers at a plurality of time points over the course of therapy with a therapeutic agent to determine a mucosal healing index for selecting therapy, optimizing therapy, reducing toxicity, and/or monitoring the efficacy of therapeutic treatment. In certain instances, the therapeutic agent is a TNFα inhibitor for the treatment of a TNFα-mediated disease or disorder. | 2022-03-31 |
20220096630 | MRNA COMBINATION THERAPY FOR THE TREATMENT OF CANCER - The present disclosure relates to the use of nucleic acid (e.g., mRNA) combination therapies for the treatment of cancer. The disclosure provides compositions, and methods for their preparation, manufacture, and therapeutic use, wherein those compositions comprise at least two polynucleotides (e.g., mRNAs) in combination wherein the at least two polynucleotides are selected from the group consisting of (i) a polynucleotide encoding an immune response primer (e.g., IL23), (ii) a polynucleotide encoding an immune response co-stimulatory signal (e.g., OX40L), (iii) a polynucleotide encoding a checkpoint inhibitor (e.g., an anti CTLA-4 antibody), and, (iv) a combination thereof. The therapeutic methods disclosed herein comprise, e.g., the administration of a combination therapy disclosed herein for the treatment of cancer, e.g., by reducing the size of a tumor or inhibiting the growth of a tumor, in a subject in need thereof. In some aspects, the combination therapies disclosed herein disclosed are administered intratumorally. | 2022-03-31 |
20220096631 | ALLOGENEIC TUMOR CELL VACCINE - The described invention provides allogeneic tumor cell vaccines comprising tumor cell lines or tumor cell line variants that are genetically engineered to express a core group of three immunomodulatory molecules, and optionally additional R immunomodulatory polypeptides for induction of one or more subpopulations of PBMCs to proliferate in response to the expressed immunomodulatory molecules and to then enter an effector phase for killing of tumor cells. According to some embodiments, the tumor cell vaccine candidate can induce an immune response in the recipient cancer patient that cross reacts with the patient's own (autologous) tumor cells, the effects of which are sufficient to result in enhanced anti-tumor immunity contributing to the increased survival of a vaccinated patient cohort compared to a matched unvaccinated patient cohort. | 2022-03-31 |
20220096632 | HIV-1 NEUTRALIZING ANTIBODIES AND USES THEREOF - The invention is directed to HIV-1 neutralizing antibodies and methods for their uses. | 2022-03-31 |
20220096633 | LONG-ACTING PHOTORECEPTOR-BINDING NANOPARTICLES, AND COMPOSITIONS AND METHODS THEREOF - The invention provides a novel class of long-acting photoreceptor-binding nanoparticles, methods of their preparation, and compositions and uses thereof. The invention also relates to use of such nanoparticles and compositions for NIR light sensation and pattern vision, visual enhancement and repair, and other ophthalmology therapies. | 2022-03-31 |
20220096634 | METHOD OF MANIPULATING PHAGES WITHIN THE BODY TO ATTACK INFECTIOUS TARGET CELLS - A method and system is disclosed for regulating, manipulating or inducing a change of activity, from lysogenic to lytic activities in native or naturally occurring phages within a subject to treat a bacterial, viral, fungal, or parasitic infection, or other pathological or biologically-physiologically advantageous target in the subject, the method including the steps of identifying the target within the subject and exposing the subject to a treatment electromagnetic signature that is suitable to induce the native phages in the subject to attack the target, or advantageously modify the target pathology or substance. The method can include implanting the treatment electromagnetic signature within an ingestible carrier medium and providing the ingestible carrier medium to the subject. | 2022-03-31 |
20220096635 | Liposomal Nanoparticle - The invention relates to a liposomal nanoparticle comprising: a liposomal vehicle comprising: one or more liposome forming lipids; and one or more destabilising agents capable of forming reactive oxygen species when exposed to an inducer; and a genome editing agent, or part thereof, and compositions and kits comprising the liposomal nanoparticle. | 2022-03-31 |
20220096636 | COMBINATION THERAPY USING RILUZOLE TO ENHANCE TUMOR SENSITIVITY TO IONIZING RADIATION - Disclosed is a method of treating a tumor in a patient, comprising (a) administering riluzole in an amount effective to sensitize the tumor cells to ionizing radiation, and (b) irradiating the tumor cells with ionizing radiation in a dose effective to reduce tumor cell growth. The method can further comprise administering an effective amount of one or more additional therapeutic agents. | 2022-03-31 |
20220096637 | Solid Solution Compositions and Use in Cardiovascular Disease - The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions. | 2022-03-31 |
20220096638 | INJECTABLE PREPARATION - An object of the present invention is to provide a storage-stable injectable preparation comprising a composition comprising a poorly soluble drug as an active ingredient and a dispersion medium. Another object of the present invention is to provide a compact, lightweight prefilled syringe by filling a syringe with the injectable preparation. The present invention provides an injectable preparation comprising a composition comprising a poorly soluble drug, a dispersion medium, and a specific suspending agent, the composition having a viscosity of 40 pascal-seconds or more in at least one point in the shear rate range of 0.01 to 0.02 s | 2022-03-31 |
20220096639 | THERMOREVERSIBLE COMPOSITIONS FOR ADMINISTRATION OF THERAPEUTIC AGENTS - The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells. | 2022-03-31 |
20220096640 | HSP90-TARGETING CONJUGATES AND FORMULATIONS THEREOF - Conjugates of an active agent attached to a targeting moiety, such as an HSP90 binding moiety, via a linker, and particles comprising such conjugates have been designed. Such conjugates and particles can provide improved temporospatial delivery of the active agent, improved biodistribution and penetration in tumor, and/or decreased toxicity. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer. | 2022-03-31 |
20220096641 | PYRROLOBENZODIAZEPINE DIMER COMPOUND WITH IMPROVED SAFETY AND USE THEREOF - The present invention relates to a novel pyrrolobenzodiazepine dimer compound or a pharmaceutically acceptable salt thereof, a ligand-drug conjugate compound thereof, or a composition containing the same and therapeutic use of the same as an anticancer agent. The pyrrolobenzodiazepine dimer compound according to the present invention exhibits anticancer activity equivalent to or superior to that of existing anticancer agents when being applied to a ligand-drug conjugate as a drug and administered as well as exhibits low activity and greatly diminished toxicity in the free toxin form and thus has a significantly improved therapeutic index. Hence, the pyrrolobenzodiazepine dimer compound is highly industrially applicable in that targeting of proliferative diseases such as cancer is possible, specific treatment of the proliferative diseases is possible, the drug efficacy can be maximized, and the expression of side effects can be minimized. | 2022-03-31 |
20220096642 | COMPOSITIONS, USE, AND METHOD FOR CDK2-PROTACS FOR CANCER THERAPY AND HEARING LOSS - Provided are CDK2-PROTAC compounds and pharmaceutical compositions thereof that can be used for specific degradation of the cyclin-dependent kinase 2 (CDK2) protein, for treatment of cancers and other CDK2 related diseases as well as for prevention and treatment of hearing loss. | 2022-03-31 |
20220096643 | Acryloyloxyethylphosphorylcholine Containing Polymer Conjugates And Their Preparation - The present invention relates to polymeric reagents and conjugates thereof, methods for synthesizing the polymeric reagents and conjugates, pharmaceutical compositions comprising the conjugates and methods of using the polymer conjugates including therapeutic methods where conjugates are administered to patients. | 2022-03-31 |
20220096644 | CD44 TARGETED MULTI-ARM CONJUGATE - Disclosed is a class of multi-branched drug conjugates capable of specifically targeting CD44. The class of compounds specifically binds to CD44, and may target tumor cells and tissues having high expression of CD44, so that the concentration of the conjugate in a target tissue is high, the clinical treatment effect thereof is improved, and toxicity is reduced. The compound of the present invention is suitable for treating all tumors having high expression of CD44, comprising but not limited to gastric cancer, pancreatic cancer, small cell lung cancer, colon cancer, breast cancer, lung adenocarcinoma, liver cancer, nasopharyngeal carcinoma, malignant glioma, lymphoma, renal carcinoma, ovarian cancer, head and neck cancer, squamous cell carcinoma, and the like. | 2022-03-31 |
20220096645 | POLYMER-DRUG CONJUGATES FOR COMBINATION ANTICANCER THERAPY - Pharmaceutical compositions comprising two or more therapeutically active agents, such as two or more anticancer agents, conjugated to one or more biocompatible polymers, wherein the molar ratio of the agents and/or schedules of delivery provide a synergistic therapeutic effect, are described. Methods of making and using the pharmaceutical compositions are further described. In one embodiment, the pharmaceutical compositions contain topoisomerase I and topoisomerase II inhibitors conjugated to the same or different biocompatible polymers. The two or more anticancer agents are covalently coupled to the polymer(s), and thereby can be delivered to a tumor at a molar ratio which provides a synergistic effect. Optionally, the agents are coupled indirectly to the polymer(s) via a linker. | 2022-03-31 |
20220096646 | SSTR-TARGETED CONJUGATES AND PARTICLES AND FORMULATIONS THEREOF - Conjugates of an active agent such as DM1 attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker, and particles comprising such conjugates have been designed. Such conjugates and particles can provide improved temporospatial delivery of the active agent, improved biodistribution and penetration in tumor, and/or decreased toxicity. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer. | 2022-03-31 |
20220096647 | COMPOSITIONS AND METHODS OF TREATING MUSCLE ATROPHY AND MYOTONIC DYSTROPHY - Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating muscle atrophy or myotonic dystrophy. | 2022-03-31 |
20220096648 | ANTIBODY-DRUG CONJUGATES COMPRISING GLP1 PEPTIDOMIMETICS AND USES THEREOF - Described herein are protein-drug conjugates and compositions thereof that are useful, for example, for targeting glucagon-like peptide 1 receptor (GLP1R). In certain embodiments, provided are peptidomimetic payloads and linker-payloads and methods of making same. More specifically, GLP1 peptidomimetics, antibody-drug conjugates, and compositions which comprise anti-GLP1R antibodies and GLP1 peptidomimetic payloads and methods of treating GLP1R-associated conditions are provided. | 2022-03-31 |
20220096649 | IMMUNOMODULATING POLYNUCLEOTIDE CONJUGATES AND METHODS OF USE - Provided herein is a conjugate for modulating a natural killer cell or myeloid cell, comprising a targeting moiety and an immunomodulating polynucleotide. Also provided herein is a pharmaceutical composition for modulating a natural killer cell or myeloid cell, comprising a conjugate comprising a targeting moiety and an immunomodulating polynucleotide, and a pharmaceutically acceptable excipient. Additionally provided herein are methods of their use for modulating a natural killer cell or myeloid cell and treating a proliferative disease. | 2022-03-31 |
20220096650 | BELANTAMAB MAFODOTIN IN COMBINATION WITH PEMBROLIZUMAB FOR TREATING CANCER - Disclosed herein are combinations of an antigen binding protein that binds BCMA with an antigen binding protein that bind to an immunomodulatory agent, such as PD-1 or OX40, pharmaceutical compositions thereof, uses thereof, and methods of treatment comprising administering said combinations, including uses in cancer. | 2022-03-31 |
20220096651 | ANTIBODIES AND CHIMERIC ANTIGEN RECEPTORS SPECIFIC FOR RECEPTOR TYROSINE KINASE LIKE ORPHAN RECEPTOR 1 (ROR1) - Provided are receptor tyrosine kinase-like orphan receptor 1 (ROR1)-binding molecules, in particular, to human antibodies specific for ROR1, including antibody fragments. The present disclosure further relates to recombinant receptors, including chimeric antigen receptors (CARs) that contain such antibodies or fragments, and polynucleotides that encode the antibodies, antigen-binding fragments or receptors specific for ROR1. The disclosure further relates to genetically engineered cells, containing such ROR1-binding proteins and receptors, and related methods and uses thereof in adoptive cell therapy. | 2022-03-31 |
20220096652 | ACETAL-BASED CLEAVABLE LINKERS - The current invention concerns compounds, such as antibody-conjugates, with an enhanced selectivity of payload release inside a tumour or in the tumour microenvironment versus payload release in circulation or in healthy cells. The enhanced selectivity is achieved by incorporation of a cleavable linker that requires two consecutive mechanisms for release of the payload. The compounds according to the invention have structure (1): | 2022-03-31 |
20220096653 | CONJUGATE COMPRISING LIGAND AND CEACAM5 ANTIBODY FAB FRAGMENT - Provided is a conjugate comprising a ligand, a spacer, and a peptide linker useful for an in-vivo diagnostic drug and internal radiation therapy, using an anti-human CEACAM5 antibody Fab fragment whose binding activity is not attenuated even by labeling with a metal, a fluorescent dye, or the like. A conjugate comprising an anti-human CEACAM5 antibody Fab fragment and a ligand, the fragment comprising a heavy chain fragment including a heavy chain variable region consisting of a specific amino acid sequence and a light chain including a light chain variable region consisting of a specific amino acid sequence, or a conjugate comprising a ligand, a spacer, and a peptide linker, wherein the binding activity thereof is not attenuated even by labeling with a metal, a fluorescent dye, or the like, can be used as a diagnostic composition and/or a pharmaceutical composition. | 2022-03-31 |
20220096654 | PYRROLOBENZODIAZEPINE-ANTIBODY CONJUGATES AND USES THEREOF - The present disclosure relates to novel pyrrolobenzodiazepine antibody-drug conjugates (PBD-ADCs) and therapeutic uses thereof. | 2022-03-31 |
20220096655 | PLASMA POLYMER NANOPARTICLES CARRYING AGENTS - The present disclosure relates to the field of nanoparticles, conjugates thereof and their use in methods of treatment or prevention of vascular inflammation. The present disclosure also relates to methods of delivering an agent to a region of a blood vessel in a patient, comprising: a) conjugating the agent to a nanoparticle to produce a conjugate; and b) delivering the conjugate to the region of the blood vessel. | 2022-03-31 |
20220096656 | NANOCARRIERS HAVING SURFACE CONJUGATED PEPTIDES AND USES THEREOF FOR SUSTAINED LOCAL RELEASE OF DRUGS - Disclosed are biodegradable nanocarriers that have a net positive surface charge and zeta potential between about +2 to about +20 mV. The positive surface charge of the nanocarriers is provided by peptides that are covalently attached to the surface of the nanocarriers. The nanocarriers may comprise a drug and may be administered for localized and sustained delivery of the drug. | 2022-03-31 |
20220096657 | COMPOSITIONS FOR THE TREATMENT OF DISEASE - The invention provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody-like polypeptides, for the prevention and/or treatment of diseases and/or disorders. | 2022-03-31 |
20220096658 | ADENO-ASSOCIATED VIRUSES AND THEIR USES FOR INNER EAR THERAPY - Provided herein are adeno-associated viruses and methods for using same to treat or prevent disorders that affect the inner ear of a subject. | 2022-03-31 |
20220096659 | METHOD FOR IMPROVING NEUROLOGICAL FUNCTION IN MPSI AND MPSII AND OTHER NEUROLOGICAL DISORDERS - A method to prevent, inhibit or treat one or more neurological symptoms associated with a central nervous system disorder, e.g. MPSI or MPSII by, for example, intrathecally, intracerebroventricularly or intravenously administering a rAAV encoding a gene product associated with the disease, e.g., administering to an adult mammal in which the gene product is absent, defective or present at a reduced level relative to a mammal without the disease. | 2022-03-31 |
20220096660 | METHODS FOR FORMING POLYPLEXES - The present disclosure relates method for forming polyplexes, which find use in gene therapy applications as safe and non-toxic nucleic acid transfection agents. | 2022-03-31 |
20220096661 | NANOPARTICLES WITH TUNABLE AFTERGLOW AND COMPOSITIONS AND METHODS THEREOF - The invention provides novel nanoparticles with tunable and multi-color afterglow emission for extended time after excitation, and compositions thereof as well as methods for their preparation and use in various applications. | 2022-03-31 |
20220096662 | MOLECULAR RENAL PROBES FOR DETECTING ACUTE KIDNEY INJURY - Disclosed herein are compounds or salts and/or solvates of formula I, II and III, where the compounds or salts and/or solvates have the following structures: (X) | 2022-03-31 |
20220096663 | PSMA LIGAND TARGETED COMPOUNDS AND USES THEREOF - Prostate-specific membrane antigen (PSMA) targeted compounds having formula (I), nanoclusters formed thereof, pharmaceutical compositions comprising a plurality of these compounds, and methods for treating and detecting cancers in a subject are described herein. | 2022-03-31 |
20220096664 | STABILIZED FORMULATIONS CONTAINING IODINATED CONTRAST AGENTS AND CYCLODEXTRINS - The invention encompasses compositions containing an iodinated contrast agent and a substituted cyclodextrin wherein the cyclodextrin stabilizes the contrast agent against degradation by ultraviolet or visible light exposure. | 2022-03-31 |
20220096665 | BIMODAL NANOPARTICLE CONJUGATES FOR NON-INVASIVE CENTRAL NERVOUS SYSTEM TISSUE IMAGING - Ligand-bimodal nanoparticle conjugates capable of crossing the blood-brain barrier are disclosed. Methods of making and using the conjugates also are disclosed. The bimodal nanoparticle includes a polymeric matrix, one or more magnetic particles disposed within the polymeric matrix or conjugated to an outer surface of the polymeric matrix, and a dye disposed within the polymeric matrix. A ligand for a blood-brain barrier amino acid transporter is conjugated to the outer surface of the bimodal nanoparticle. | 2022-03-31 |
20220096666 | ULTRASOUND CONTRAST AGENT AND METHODS FOR USE THEREOF - The present disclosure is directed to an ultrasound contrast agent comprising microbubbles of perfluorocarbon, which microbubbles are stabilised by a membrane of phospholipid; and a buffering agent; wherein the ultrasound contrast agent has a bulk pH of from about 7.5 or above, preferably about 8.5 or above. The ultrasound contrast agent is for long-term storage and is ready for use in vivo. Further disclosed is a method for preparing such an ultrasound contrast agent and methods for use of an ultrasound contrast agent in a clinical setting. | 2022-03-31 |
20220096667 | Compound Targeting Norepinephrine Transporter - A compound according to following formula can be prepared, | 2022-03-31 |
20220096668 | PSMA BINDING DUAL MODE RADIOTRACER AND THERAPEUTIC - The present invention relates to a compound according to formula (V): or a pharmaceutically acceptable salt thereof, optionally containing a chelated radioactive cation and wherein F is optionally | 2022-03-31 |
20220096669 | SILICON-FLUORIDE ACCEPTOR SUBSTITUTED RADIOPHARMACEUTICALS AND PRECURSORS THEREOF - A ligand-SiFA conjugate compound represented by formula ( | 2022-03-31 |
20220096670 | PORTABLE AND WEARABLE DISINFECTING POUCH - A portable and wearable disinfecting pouch includes a waistbelt and a disinfecting pocket positioned on the waistbelt. The disinfecting pocket includes a first opening, a second opening, and an interior. The first opening is on a first end of the disinfecting pocket. The second opening is on a second end of the disinfecting pocket. The interior is positioned between the first opening and the second opening. A sanitizing pad is positioned in the interior of the disinfecting pocket. The sanitizing pad contains a sanitizing formula configured for disinfecting or sanitizing hands, accessories, or items. | 2022-03-31 |
20220096671 | TOILET EQUIPPED WITH INFRARED GENERATOR - The present invention relates to a toilet equipped with an infrared generator. The toilet equipped with an infrared generator is fabricated by separately forming a toilet body provided with an infrared generator in one side surface thereof, a bowl made of a material through which infrared rays emitted by the infrared generator can be transmitted and furnished with an infrared ray transmission region without the formation of a hole, and a rim conduit and then coupling the infrared generator, the bowl, and the rim conduit to the separately formed toilet body. The toilet equipped with an infrared generator enables the infrared generator to be easily installed without forming a hole into the bowl, and can prevent excretions, such as urine and feces, from leaking to the infrared generator. | 2022-03-31 |
20220096672 | TOWEL DISINFECTION DRYER - The present application provides a towel disinfection dryer, comprising a main machinery, wherein the main machinery comprises a housing, an ultraviolet light source installed in the housing, a reflector arranged above the ultraviolet light source, a heater installed in the housing, and a fan installed in the housing, the reflector is installed in the housing, the bottom of the housing is provided with a window exposing the ultraviolet light source, and the bottom of the housing corresponding to the outlet of the fan is provided with an air outlet, the heater is arranged on the airflow path of the fan, the reflector defines one or more airflow holes, and the reflector is arranged on the airflow path of the fan. | 2022-03-31 |
20220096673 | TOWEL DISINFECTING AND DRYING MACHINE - Disclosed is a towel disinfecting and drying machine, including a main machine which includes casing, ultraviolet LED module, heater, and fan. The bottom of the casing is provided with air outlet corresponding to the outlet of the fan and air inlet, and the heater is located in the air flow path of the fan. The ultraviolet LED module includes basal plate installed on the bottom of the casing and ultraviolet LED lamp bead(s) installed on the basal plate. Fan is used to blow out heat for drying; ultraviolet LED module is installed on the bottom of the casing to emit ultraviolet light for disinfecting, which can simplify the structure, is more energy-saving and has a long life; because of the small size of the ultraviolet LED module, easy layout, and small occupied space, the main machine can be made smaller, which is convenient for users to install and use. | 2022-03-31 |
20220096674 | STERILIZATION CASE - A sterilization case includes a case body, a transparent plate, and at least one ultraviolet light source. The case body is adapted to contain an object. The transparent plate is disposed in the case body and has a supporting surface. When the transparent plate supports the object, a surface of the object leans against the supporting surface. The ultraviolet light source is disposed in the case body and adapted to provide ultraviolet light, and the ultraviolet light passes through an interior of the transparent plate and is transmitted toward the supporting surface to irradiate the surface of the object. | 2022-03-31 |
20220096675 | Techniques for Directing Ultraviolet Energy Towards a Moving Surface - An ultraviolet (“UV”) emission device may emit energy towards a movable surface of a conveyor system. A housing of the UV emission device may attach to a frame of the conveyor system. A lateral edge of the housing may extend across the moveable surface. The housing and a portion of the moveable surface may be inclined with respect to the frame. A barrier bracket of the UV emission device may support an absorptive barrier along the lateral edge, the absorptive barrier configured to contact the moveable surface. In a first position of the barrier bracket, the absorptive barrier contacts the moveable surface and the barrier bracket activates an interlock switch. In a second position of the barrier bracket, the barrier bracket deactivates the interlock switch. Responsive to deactivation of the interlock switch, a controller may provide a control signal to decrease power to the UV energy emission element. | 2022-03-31 |
20220096676 | Techniques for Directing Ultraviolet Energy Towards a Moving Surface - An ultraviolet (“UV”) emission device may emit energy towards a movable surface of a conveyor system. A housing of the UV emission device may attach to a frame of the conveyor system. A lateral edge of the housing may extend across the moveable surface. The housing and a portion of the moveable surface may be inclined with respect to the frame. A barrier bracket of the UV emission device may support an absorptive barrier along the lateral edge, the absorptive barrier configured to contact the moveable surface. In a first position of the barrier bracket, the absorptive barrier contacts the moveable surface and the barrier bracket activates an interlock switch. In a second position of the barrier bracket, the barrier bracket deactivates the interlock switch. Responsive to deactivation of the interlock switch, a controller may provide a control signal to decrease power to the UV energy emission element. | 2022-03-31 |
20220096677 | Optical Disinfection Systems Having Side-Emitting Optical Fiber Coupled to High-Energy UV-C Laser Diode - High-energy optical disinfection systems inside a commercial airplane using highly efficient, flexible, and durable side-emitting optical fibers optically coupled to high-energy UV-C laser diodes to destroy submicroscopic infectious agents and inactivate microorganisms inside the airplane. With the high-energy UV-C laser diodes optically coupled to the side-emitting optical fibers, which can be easily routed to different areas inside the airplane, the high-energy UV-C laser light emitted from the side of the optical fiber will disinfect the airplane along a wide or long swath continuously without interruption. | 2022-03-31 |
20220096678 | DEVICE FOR DISINFECTING AT LEAST ONE OBJECT - The invention relates to a device for disinfecting at least one object, which device is provided with at least one UV-C light source by means of which UV-C light can be emitted in a closable chamber of the device, wherein at least one object-suspension element permeable to UV-C light is provided in the chamber, by means of which the object can be suspended in the chamber. | 2022-03-31 |
20220096679 | FLASHLAMP CARTRIDGE FOR DECONTAMINATION AND DECONTAMINATION UNIT - A flashlamp cartridge for a decontamination unit. The cartridge includes a flashtube for pulsed emissions of ultraviolet light and a sheath encapsulating the flashtube. | 2022-03-31 |
20220096680 | SYSTEMS AND METHODS OF UV CLEANING - The present disclosure provides a system including an ultraviolet (UV) light source, a power source configured to provide power to the UV light source, and a photochromatic indicator associated with a component, the photochromatic indicator being in a first state, the UV light source being configured to change the photochromatic indicator from a first state to a second state, the second state indicating that the component has been cleaned, the second state being visible to a naked eye under ambient lighting. | 2022-03-31 |
20220096681 | Techniques for Directing Ultraviolet Energy Towards a Moving Surface - An ultraviolet (“UV”) emission device may emit energy towards a movable surface of a conveyor system, A housing of the UV emission device may attach to a frame of the conveyor system. A lateral edge of the housing may extend across the moveable surface. The housing and a portion of the moveable surface may be inclined with respect to the frame. A barrier bracket of the UV emission device may support an absorptive barrier along the lateral edge, the absorptive barrier configured to contact the moveable surface. In a first position of the barrier bracket, the absorptive barrier contacts the moveable surface and the barrier bracket activates an interlock switch. In a second position of the barrier bracket, the barrier bracket deactivates the interlock switch. Responsive to deactivation of the interlock switch, a controller may provide a control signal to decrease power to the UV energy emission element. | 2022-03-31 |
20220096682 | VEHICLE IGNITION INTERLOCK DECONTAMINATION AND CALIBRATION STATION - A decontamination and calibration station for vehicle ignition interlock devices that includes a self-contained structure that receives and encloses an interlock device operatively connected thereto. The station includes at least one calibration reference standard operatively connected to a valve assembly of the station, which is fluidly and operatively connected to an interior of the station and the interlock device for calibration of the device. The station includes a decontamination feature to sanitize and disinfect the station and/or the interlock device. The decontamination feature can include at least one UV-C bulb fixture mounted in the station and/or disinfectant operatively connected to the station and interlock device. The station includes a control system for controlling calibration of the interlock device and the decontamination feature, which can be a computer operatively connected directly to the interlock device and the station or a processor integrated into the station controlled by a remote device. | 2022-03-31 |
20220096683 | BIMODAL ULTRAVIOLET DISINFECTION SYSTEMS AND RELATED METHODS - A system for disinfecting an enclosed space includes a housing, ultraviolet (UV) emitters, a sensor to detect occupancy in or entry into an enclosed space, a UV directing mechanism, and a controller. The housing includes an air flow passageway. When the UV directing mechanism is in the closed state, the UV emitters are positioned in the air flow passageway and transmission of UV electromagnetic radiation into the enclosed space is substantially blocked. UV electromagnetic radiation is transmitted into the enclosed space when the UV directing mechanism is in the at least one open state. Disinfection operations can be activated when the UV directing mechanism is in the open state or the closed state. When the UV directing mechanism is in the open state, the disinfection operation is activated when the sensor indicates no occupancy in or no entry into the enclosed space. | 2022-03-31 |
20220096684 | VEHICLE HAVING DISINFECTION SYSTEM - A vehicle includes a disinfection system for combating biological, viral, fungal and parasitic agents. The vehicle includes a power source and is configured to generate at least one signal indicative the vehicle operation status. The disinfection system includes at least one electromagnetic emission device arranged to emit electromagnetic radiation; a controller having a plurality of stored scenarios. The controller is configured to receive the signal and to use the signal to select a scenario from the plurality of stored scenarios. The controller has output means to output control signals to the at least one electromagnetic emission device to control at least one of the intensity, wavelength, and duration of the emitted electromagnetic radiation in response to the selected scenario. | 2022-03-31 |
20220096685 | MICROWAVE ASSISTED METHODS AND SYSTEMS FOR SURFACE DECONTAMINATION - Disclosed are microwave assisted methods and systems for decontaminating a variety of contaminated surfaces. The systems and methods comprise treating the surfaces with benign chemical formulations followed by exposing to microwave irradiation for short periods of time to achieve at least 6-log reduction in biological contaminants including spores of | 2022-03-31 |
20220096686 | Pathogen Inactivation by Exposure to a Noble Gas - A method for inactivating and/or destroying microscopic biological pathogens includes placing an object to be treated in a pressure vessel, exposing the object to a pressurized noble gas at a selected target treatment pressure for a selected treatment time duration, then decreasing the treatment chamber pressure from the target treatment pressure to external atmospheric pressure within a selected depressurization time duration. The method has been tested effective against pathogens for target treatment pressure in a range from 60 psi to 150 psi and treatment time duration in a range from 300 seconds to 600 seconds. | 2022-03-31 |
20220096687 | Sanitizer Aerosol Dispensing Apparatus - A sanitizer aerosol dispensing apparatus suited for disinfecting enclosed areas is presented. The sanitizer aerosol dispensing apparatus contains a dispenser canister, a dispensing mechanism, and a weighted base. The dispenser canister contains a top portion, a bottom portion, and a liquid reservoir. The liquid reservoir is positioned within the dispenser canister. The dispensing mechanism is connected adjacent to the dispenser canister. The dispensing mechanism is in fluid communication with the liquid reservoir, where the dispensing mechanism is configured to dispense a fluid from the liquid reservoir. The weighted base is positioned adjacent to the bottom portion, opposite to the top portion. | 2022-03-31 |
20220096688 | Novel Pens/Pencils Sanitizing Machine - Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus. COVID-19 is affecting the whole world and it's not only taking lives but also heavily penalizing the economy. This new invention ‘Novel Pens/Pencils Sanitizing Machine’ helps in reducing the risks of getting COVID-19 and other common infectious diseases like Flu, common cold etc. through the use of common pens and pencils. Many facilities front desk like schools, doctor's offices, Hospitals, private offices share the same pens or pencils with others or sanitizes the pens or pencils manually which is a time taking and tedious job. This machine sanitizes bunch of pens and pencils in one go in an automated way. | 2022-03-31 |
20220096689 | PORTABLE STERILIZATION AND DISINFECTION APPARATUS FOR STERILIZING AND DISINFECTING SPACE - Disclosed is a portable sterilization and disinfection apparatus for sterilizing and disinfecting a space, wherein the portable sterilization and disinfection apparatus may enable ultrafine spray and accurate oriented spray, may expand a spraying distance, and may be freely moved to any space so as to effectively sterilize and disinfect the space. | 2022-03-31 |
20220096690 | Aura Disinfecting Machine - The application provides a disinfecting device. The device comprises an aircraft trolley-sized body comprising two side surfaces. The body is adapted to move along a longitudinal axis of an aisle of an aircraft such that the side surfaces face two opposing sides of the aisle. The device includes a powering unit, at least one air compressor for providing compressed air, a disinfectant bottle for storing liquid disinfectants, and at least two nozzle assemblies. Each nozzle assembly includes an electrically actuated valve, a connector, and at least three nozzles. The compressed air flows from the compressor to the valve, to the connector, and to the nozzles to form droplets of disinfectants. The nozzles are provided on upper surfaces of the body such that the nozzles point away from the respective side surfaces for spraying the disinfectants onto objects located on the two opposing sides of the aisle. | 2022-03-31 |
20220096691 | CASING AND MANUFACTURING METHOD THEREOF - The disclosure provides a casing including a substrate, a transparent fluorescent identifying part, and a transparent antibacterial film. The transparent fluorescent identifying part is disposed on the substrate. The transparent antibacterial film covers the substrate and the transparent fluorescent identifying part. A method of manufacturing the casing is also provided. | 2022-03-31 |
20220096692 | OZONE, UVC LIGHT AND STEAM SANITIZER WITH ULTRASONIC NEBULIZER - A device that works with electrical energy through the source ( | 2022-03-31 |
20220096693 | ENCLOSED SPACE ULTRAVIOLET DISINFECTION SYSTEMS AND RELATED METHODS - A system for disinfecting an enclosed space includes an ultraviolet (UV) disinfection assembly, a sensor to detect occupancy in or entry into the enclosed space, and a controller. The UV disinfection assembly includes UV emitters. The controller controls operation of the UV emitters to carry out disinfection operations, each of a predetermined UV dose. The controller activates a disinfection operation in a first mode when: (1A) the sensor indicates no occupancy in or no entry into the enclosed space. The controller activates a disinfection operation in a second mode when: (2A) the sensor indicates no occupancy in or no entry into the enclosed space, and (2B) there is a qualified human input through a human-machine interface (HMI) in communication with the controller. The controller suspends or deactivates the disinfection operation when the sensor indicates occupancy in or entry into the enclosed space. | 2022-03-31 |
20220096694 | ELECTRONIC DEVICE WITH ANTIBACTERIAL EFFECT DETECTION AND PORTABLE DEVICE - An electronic device with antibacterial effect detection and a portable device are provided. The electronic device includes an antibacterial housing, a light emitting unit, a light receiving unit and a processing unit. The antibacterial housing has a concave hole, which gradually shrinks from the inside to the outside. The light emitting unit is arranged under the concave hole of the antibacterial housing. The light emitting unit is used for emitting a detection light toward an inclined side wall of the concave hole. The light receiving unit is arranged under the concave hole of the antibacterial housing. The light receiving unit is used for receiving a detection light reflected from the inclined side wall of the concave hole. The processing unit is used for analyzing the antibacterial effect of the antibacterial housing according to the detection light. | 2022-03-31 |
20220096695 | COMPOSITION FOR DIFFUSING VOLATILE SUBSTANCES - A composition for diffusing volatile substances, comprising wax, which further comprises a solid material that includes volatile substances, said solid material being in the form of particles, and which has a volatile substance absorption capacity greater than the volatile substance absorption capacity of the wax. It enables a composition for diffusing volatile substances to be obtained which enables the percentage of volatile substances to be increased, that is, the percentage of fragrance, and the release time to be lengthened. | 2022-03-31 |
20220096696 | Device For Disinfecting Air By Means Of Combustion | 2022-03-31 |
20220096697 | SYSTEM FOR SCENTING ROOMS - A sustainable system for scenting rooms, having a solid body for the situation and evaporation of a liquid mixture that contains at least one fragrance, the body having a porous, ceramic, and reusable material and the material of the body having an open porosity that is greater than 50%, the mixture having a flash point that is equal to or below 120° C. In addition, a method is described for producing the body and for preparing the system for reuse. | 2022-03-31 |
20220096698 | Systems and Methods for Atomizing Liquids - Atomizers and methods for operating atomizers for dispersing vapor into the ambient air are disclosed. Liquid from a vessel connected to the atomizer may be pumped to a first chamber having an atomizing element at or near the bottom of the first chamber. The atomizing element may convert the liquid to a vapor, and a fan may push air into the first chamber, causing the vapor to be dispersed into the ambient air through apertures at or near the top of the first chamber. Liquid remaining in the first chamber may be pumped back to the vessel, while the fan continues to run to dry the components in the first chamber. | 2022-03-31 |
20220096699 | SANITIZING DEVICE WITH PATHOGEN DETECTION, SANITIZING SYSTEM WITH PATHOGEN DETECTION, AND METHODS FOR USE THEREOF - Sanitizing devices may be configured to emit sanitizing light into an environment in order to sanitize air, objects, and/or surfaces in the environment. The sanitizing light may be of a wavelength, or set of wavelengths, that deactivates, kills, or neutralizes, pathogens such as bacteria and viruses but, is not harmful to human or animal tissue. The sanitizing devices may be configured to be able to communicate with each other and/or a user over, for example, the Internet, a wireless communication network, a mesh network, and/or a near-field communication protocol in order to, for example, provide operation information and/or receive operation instructions. | 2022-03-31 |
20220096700 | DEVICE THAT USES ULTRAVIOLET LIGHT TO PURIFY AIR - Implementations of the present subject matter are directed toward a device for purifying air. The device for purifying air may include a conduit, a sheet, a light emitting diode and a fan. The conduit may have an inlet, an outlet and a plenum that couples the inlet to the outlet. The sheet may be at the inlet within the conduit and may be configured to filter bio aerosols from air or other fluid entering the conduit. The light emitting diode may be within the conduit and the fan may be positioned at the outlet. | 2022-03-31 |
20220096701 | AIR PURIFICATION AND DISINFECTION APPARATUS AND METHODS OF USE - An air purification and disinfection system includes an apparatus having a housing, an ultraviolet disinfection chamber, an air mover, and an air distribution unit in communication with the disinfection chamber. Air is passed through the disinfection chamber where it is purified and disinfected before it is delivered to the user of the apparatus through the air distribution unit. The apparatus can be configured as an open or a closed circuit system. The system may be configured to purify air in an airplane, a conference room, a classroom, or as a portable unit for an individual user. As a portable unit the disinfection chamber can be incorporated into a back pack, a vest, a purse, a briefcase, a shoulder bag, a cervical collar, or any other format for being carried by the user. | 2022-03-31 |
20220096702 | METHOD AND SYSTEM FOR LED BASED VIRUS AND BACTERIA REMOVAL | 2022-03-31 |
20220096703 | PHOTOCATALYTIC OXIDATION CENTRIFUGAL FAN - A centrifugal fan for a heating, ventilation, air conditioning, and refrigeration (HVACR) system is disclosed. The centrifugal fan includes a volute housing having an inner surface and a curved inlet shroud. The volute housing defines an air outlet. The curved inlet shroud defines an air inlet. The air inlet has an inlet airflow cross-sectional area that lies substantially perpendicular to an outlet airflow cross-sectional area of the air outlet. The centrifugal fan also includes an impeller mounted for rotation about a rotational axis within the volute housing. The impeller has a plurality of fan blades. The plurality of fan blades has an outer surface. The centrifugal fan further includes a light source. The inner surface of the volute housing and the outer surface of the plurality of fan blades includes a photocatalyst layer. The light source is configured to emit light on the photocatalyst layer. | 2022-03-31 |
20220096704 | FIBRES, A PROCESS FOR PRODUCING SUCH FIBRES AND A WOUND DRESSING INCORPORATING THEM - Multi component fibres for the reduction of the damaging activity of wound exudate components such as protein degrading enzymes and inflammatory mediators in wounds, the fibres comprising: from 10% to 100% by weight of the fibres of pectin and a sacrificial proteinaceous material in a weight ratio of 100:0 to 10:90 pectin to sacrificial proteinaceous material and from 0% to 90% by weight of the fibres of another polysaccharide or a water soluble polymer. | 2022-03-31 |
20220096705 | VACUUM MEMBRANE THERMOFORMED POLY-4-HYDROXYBUTYRATE MEDICAL IMPLANTS - Methods to produce thermoformed implants comprising poly-4-hydroxybutyrate homopolymer, copolymer, or blend thereof, including surgical meshes, have been developed. These thermoforms are preferably produced from porous substrates of poly-4-hydroxybutyrate homopolymer or copolymer thereof, such as surgical meshes, by vacuum membrane thermoforming. The porous thermoformed implant is formed by placing a porous substrate of poly-4-hydroxybutyrate homopolymer or copolymer thereof over a mold, covering the substrate and mold with a membrane, applying a vacuum to the membrane so that the membrane and substrate are drawn down on the mold and tension is applied to the substrate, and heating the substrate while it is under tension to form the thermoform. The method is particularly useful in forming medical implants of poly-4-hydroxybutyrate and copolymers thereof, including hernia meshes, mastopexy devices, breast reconstruction devices, and implants for plastic surgery, without exposing the resorbable implants to water and without shrinking the porous substrate during molding. | 2022-03-31 |
20220096706 | ELECTROSPUN NANOFIBER-BASED DRESSINGS AND METHODS OF MANUFACTURE AND USE THEREOF - Nanofiber structures are provided as well as methods of use thereof and methods of making. | 2022-03-31 |
20220096707 | HEMOSTATIC MATERIAL - A hemostatic material includes a lipid that can accelerate adhesion or aggregation of platelets even if the lipid does not carry a protein or a peptide involved in adhesion or aggregation of platelets such as GPIb and H12 and, to achieve the object, provides a hemostatic material including a water-insoluble base and a lipid supported on a surface of the base, wherein the lipid includes one or two or more anionic lipids. | 2022-03-31 |
20220096708 | HEMOSTATIC COMPOSITIONS AND METHODS OF MAKING THEREOF - The present invention is directed to hemostatic compositions comprising at least partially integrated agglomerated ORC fibers, fibrinogen, and thrombin and methods of forming a powdered hemostatic composition, comprising the steps of: forming a suspension of a mixture comprising particles of fibrinogen, thrombin, ORC fibers in a non-aqueous low boiling solvent; spraying the suspension through a nozzle onto a substrate, allowing the non-aqueous solvent to evaporate; separating from the substrate and sieving the composition. | 2022-03-31 |
20220096709 | WOUND HEALING THERAPEUTIC HYDROGELS - Provided are hydrogel-based compositions and materials for wound healing and methods of using same. The hydrogel comprises nanofibers formed from protein Q, which is a variant of the cartilage oligomeric matrix protein coiled coil (COMPcc) protein, or a protein having at least 85% homology with protein Q. The hydrogel has one or more wound healing agents distributed therein and associated with the Q fibers. The wound healing agent may be exosomes, which may be exosomes produced by cells, such as exosomes produced by multipotent stromal cells and/or one or more triterpenoids. The hydrogels may be used in treatment of wounds, such as chronic wounds. | 2022-03-31 |
20220096710 | COLLAGEN SCAFFOLDS - Methods for preparing and using collagen extracts and collagen scaffolds are provided. Additionally, methods and related kits for the repair of articular tissue using the collagen material are provided. | 2022-03-31 |
20220096711 | METHOD OF FACILITATING NERVE GROWTH - Disclosed are methods, devices and materials for the in situ formation of a nerve cap and/or a nerve wrap to inhibit neuroma formation following planned or traumatic nerve injury. The method includes the steps of identifying a severed end of a nerve, and positioning the severed end into a cavity defined by a form. A transformable media is introduced into the form cavity to surround the severed end. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the severed end. The media may be a hydrogel, and the transformation may produce a synthetic crosslinked hydrogel protective barrier. The media may include at least one anti-regeneration agent to inhibit nerve regrowth | 2022-03-31 |
20220096712 | BIOMATERIALS COMPRISING A SCAFFOLD CONTAINING A MINERAL COMPOUND, AND USES THEREOF AS BONE SUBSTITUTES - The present invention concerns a biomaterial comprising a scaffold containing a mineral component, wherein said mineral component comprises at least one calcium phosphate compound, and wherein said scaffold has a surface coated with an interrupted coating made of multilayered droplets, said multilayered droplets being droplets composed of at least one layer pair consisting of a layer of polyanions and a layer of polycations. | 2022-03-31 |
20220096713 | SINGLE CONDUIT HEART VALVE WITH UNITARY LEAFLET AND SKIRT - Embodiments herein relate to prosthetic heart valves constructed with animal tissue wherein the leaflets are unitary with the inner skirt. In an embodiment, an implantable heart valve assembly is included having a plurality of valve leaflets, an inner skirt, and a metal frame, wherein the plurality of valve leaflets and the inner skirt are formed of a continuous piece of animal tissue. In another embodiment, a method of making an implantable heart valve assembly is included, the method including placing a piece of pericardial tissue over a mold, cross-linking the pericardial tissue in place over the mold, removing the pericardial tissue from the mold, and attaching the pericardial tissue to a frame, wherein the pericardial tissue forms a seamless junction between a plurality of valve leaflets and an inner skirt. Other embodiments are also included herein. | 2022-03-31 |
20220096714 | BONE AUGMENTATION UTILIZING MUSCLE-DERIVED PROGENITOR COMPOSITIONS IN BIOCOMPATIBLE MATRIX, AND TREATMENTS THEREOF - The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non-soft tissue (e.g. bone) when combined with a biocompatible matrix, preferably SIS. The invention further provides methods of using compositions comprising muscle-derived progenitor cells with a biocompatible matrix for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age. | 2022-03-31 |
20220096715 | STRUCTURED GELS - The invention relates to a method for assembling a clay-nanoparticle gel suitable for loading with one or more molecule species such that they are spatially structured therein, and a method for forming a clay-nanoparticle gel comprising one or more spatially structured molecule species. The invention further relates to structured clay nanoparticle gel and their use, for example in treatment. | 2022-03-31 |
20220096716 | MEDICAL IMPLANTS INCLUDING LAMINATES OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS THEREOF - Methods to produce laminates including layers of constructs made from P4HB and copolymers thereof have been developed. These laminates may be used as medical implants, or further processed to make medical implants. The laminates are produced at a temperature equal to or greater than the softening points of the P4HB or copolymers thereof. The layers may include oriented forms of the constructs. Orientation can be preserved during lamination so that the laminate is also oriented, when the laminates are formed at temperatures less than the de-orientation temperatures of the layers. The laminate layers may include, for example, films, textiles, including woven, knitted, braided and non-woven textiles, foams, thermoforms, and fibers. The laminates preferably include one or more oriented P4HB films. | 2022-03-31 |
20220096717 | AXITINIB-LOADED NANOFIBER MEMBRANE, PREPARATION METHOD FOR THE SAME, AND ITS USE OF ANTI-ADHESION AFTER A SURGERY - The application discloses a use of nanofiber membrane in the preparation of medical apparatus for anti-adhesion after a surgery, wherein small molecule drug, inhibiting vascular endothelial growth factor and/or inhibiting vascular endothelial growth factor receptor, is loaded into the nanofiber membrane. The nanofiber membrane provided in the present application has the following advantages: it has good biocompatibility, excellent mechanical properties, excellent flexibility and smoothness when exposed to water, good air permeability, and has the ability to effectively prevent adhesion between the heart and surrounding tissues. In addition, it can also be applied to other surgical operations, such as prevention of adhesions in the abdominal cavity, pelvis, and tendons. | 2022-03-31 |
20220096718 | BLOOD CIRCUIT ASSEMBLY FOR A HEMODIALYSIS SYSTEM - A blood circuit assembly for a dialysis unit may include an organizing tray, a pair of pneumatic pumps mounted to the organizing tray for circulating blood received from a patient through a circuit including a dialyzer unit and returned to the patient, an air trap mounted to the organizing tray arranged to remove air from blood circulating in the circuit, a pair of dialyzer connections arranged to connect to the inlet and outlet of a dialyzer unit, and a pair of blood line connectors, one inlet blood line connector for receiving blood from the patient and providing blood to the pneumatic pumps and the other outlet blood line connector for returning blood to the patient. | 2022-03-31 |
20220096719 | APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT - An extracorporeal blood treatment apparatus is provided comprising a filtration unit connected to a blood circuit and to a dialysate circuit, a preparation device for preparing and regulating the composition of the dialysis fluid; a control unit is configured for setting a sodium concentration value for the dialysis fluid in the dialysis supply line at a set point based on the physician prescription; starting from the initial patient plasma conductivity, estimated at the beginning of the treatment, and based on the target plasma conductivity/sodium concentration which is equivalent to the dialysate conductivity/sodium concentration prescribed, the control unit determines the minimum constant gradient between dialysis fluid and plasma conductivity/concentration to be maintained during treatment to achieve the conductivity/concentration target in the patient plasma at the end of the session. | 2022-03-31 |
20220096720 | APPARATUS FOR AN EXTRACORPOREAL BLOOD TREATMENT - The present invention relates to an apparatus for an extracorporeal blood treatment having an extracorporeal blood circuit in which a dialyzer is arranged and having a dialyzate circuit, wherein the blood circuit is in fluid communication with a first chamber and the dialyzate circuit is in fluid communication with a second chamber of the dialyzer, and wherein the two chambers are separated from one another by a semipermeable membrane, with a dialyzate pump for a conveying of the dialysis solution being present in the dialyzate circuit, wherein the apparatus has a control unit that is configured to operate the apparatus in a first phase and in a second phase following the first phase, wherein the dialyzate pump is operated with a smaller flow rate in the first phase than in the second phase and/or wherein the dialyzate pump conveys a dialysis solution in the first phase that is of a higher concentration with respect to at least one component than in the second phase. | 2022-03-31 |
20220096721 | ARTIFICIAL LUNG DEVICE - An artificial lung device includes: a housing which is formed in a tubular shape including both end portions closed, includes a blood inflow port and a blood outflow port, and is arranged such that a center axis of the housing is directed in a lateral direction; a hollow fiber body (gas exchanger) which is arranged in the housing and performs gas exchange with respect to blood while the blood flows from the blood inflow port to the blood outflow port; and a straightening frame (gas guide portion) by which a gas having flowed through the gas exchanger by the flow of the blood is guided to the gas exchanger again in the housing. | 2022-03-31 |
20220096722 | SYSTEM, COMPUTER SYSTEM AND COMPUTER PROGRAM FOR DETERMINING A CARDIOVASCULAR PARAMETER - The invention relates to a system for determining a cardiovascular parameter in a patient, wherein the system is adapted to work in conjunction with an extracorporeal blood treatment device (ECBTD) connectable to a patient's vascular system, wherein the ECBTD comprises a first circuit, the system comprising: a liquid-filled, second circuit thermally connected to the first circuit of the ECBTD via a heat exchanger, temperature changing means for generating a temperature change in the second circuit, temperature sensors TS2up and TS2down arranged in the second circuit upstream and downstream of the heat exchanger, respectively. A computer system connected to the temperature sensors and the temperature changing means is adapted to induce a temperature bolus within the first circuit of the ECBTD via the temperature changing means. From the individual temperature recorded as a function of time, temperature curves T2up(t) and T2down(t) are derived and evaluated. | 2022-03-31 |
20220096723 | REGIONAL DECOAGULATION SYSTEM FOR EXTRACORPOREAL BLOOD-CIRCULATION CIRCUIT - A system is described for the regional decoagulation of the blood in an extracorporeal circulation circuit comprising means for infusion of a solution of a citrate or citric acid on the main circuit, which are set upstream of the first filtration unit; for infusion of a solution for electrolyte restoration on the main circuit, which are set downstream of the filtration unit and a secondary circuit for recirculation of the plasma water obtained by the filtration unit. The secondary circuit comprises: a first cartridge comprising an anion-exchange resin charged with chlorine ions; a second cartridge comprising a cation-exchange resin charged with sodium and potassium ions, which is set downstream of the first cartridge and means for removal of a first fraction of the plasma water obtained by the filtration unit. | 2022-03-31 |
20220096724 | PROCESS FOR REMOVING IONS FROM BODILY FLUIDS USING SMALL MOLECULE METAL CHELATORS AND METALLATE ION EXCHANGE COMPOSITIONS - A process for removing Pb | 2022-03-31 |
20220096725 | CENTRIFUGE BOWL AND BLOOD CENTRIFUGE SYSTEM - A centrifuge bowl is configured to separate a first component and a second component in a sample. The centrifuge bowl includes a shell, a core, a separation cavity, and a stator head. The shell includes an upper shell part, a middle shell part, a lower shell part, and a bottom shell part. The core is arranged in the shell. The separation cavity is arranged between the lower shell part and the core. The stator head is arranged on the shell and includes an input tube and an output tube. The sample enters the separation cavity via the input tube. When the shell and the core rotate on a rotation axis, the sample in the separation cavity is separated into the first component and the second component according to a magnitude of an inertial force. In addition, a blood centrifuge system including the above centrifuge bowl is provided. | 2022-03-31 |