13th week of 2013 patent applcation highlights part 52 |
Patent application number | Title | Published |
20130079343 | 1,3,6-Substituted Indole Derivatives Having Inhibitory Activity for Protein Kinase - Disclosed are a 1,3,6-substituted indole compound having inhibitory activity for protein kinases, a pharmaceutically acceptable thereof, and a pharmaceutical composition for prevention and treatment of diseases caused by abnormal cell growth including the compound as an active ingredient. | 2013-03-28 |
20130079344 | OPHTHALMOLOGIC IRRIGATION SOLUTIONS AND METHOD - Solutions for perioperative intraocular application by continuous irrigation during ophthalmologic procedures are provided. These solutions include multiple agents that act to inhibit inflammation, inhibit pain, effect mydriasis (dilation of the pupil), and/or decrease intraocular pressure, wherein the multiple agents are selected to target multiple molecular targets to achieve multiple differing physiologic functions, and are included in dilute concentrations in a balanced salt solution carrier. | 2013-03-28 |
20130079345 | PHARMACEUTICALLY ACTIVE DISUBSTITUTED TRIAZINE DERIVATIVES - The present invention relates to disubstituted triazine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, immunological diseases, autoimmune diseases, cardiovascular diseases, cell proliferative diseases, inflammation, erectile dysfunction and stroke, and pharmaceutical compositions containing at least one of said disubstituted triazine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said disubstituted triazine derivatives as inhibitors for a protein kinase. | 2013-03-28 |
20130079346 | BENZOIC ACID DERIVATIVES - There are disclosed are compounds of the formula: | 2013-03-28 |
20130079347 | NOVEL SULFONYLPYRROLES - Compounds of a certain formula (I), in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, are novel effective HDAC inhibitors. | 2013-03-28 |
20130079348 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM - Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity. | 2013-03-28 |
20130079349 | 5-AMINO-3,6-DIHYDRO-1H-PYRAZIN-2-ONE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) - The present invention relates to novel 5-amino-3,6-dihydro-1H-pyrazin-2-one derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease or dementia associated with beta-amyloid. | 2013-03-28 |
20130079350 | Substitute 2-amino-3-(Sulfony)pyrazol[1,5-a]pyramidines - serotonin 5-ht6 receptor antagonists, method for us thereof - The present invention relates to novel substituted 2-amino-3-(arylsulfonyl)pyrazolo[1,5-a]pyrimidines of general formula 1, to serotonin 5-HT | 2013-03-28 |
20130079351 | 2-ACYLAMINOTHIAZOLE DERIVATIVE OR SALT THEREOF - A 2-acylaminothiazole derivative or a pharmaceutically acceptable salt thereof having an excellent effect of proliferating human c-mpl-Ba/F3 cells and an activity of increasing platelets based on the effect of promoting the formation of megakaryocytic colonies. A compound or a pharmaceutically acceptable salt thereof useful in treating thrombocytopenia. | 2013-03-28 |
20130079352 | PYRIDO[3,4-B]INDOLES AND METHODS OF USE - This disclosure relates to new heterocyclic compounds that may be used to modulate a histamine receptor in an individual. Pyrido[3,4-b]indoles are described, as are pharmaceutical compositions comprising the compounds and methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder. | 2013-03-28 |
20130079353 | FLUOROQUINOLONES FOR THE TREATMENT AND/OR PROPHYLAXIS OF INFLAMMATORY DISEASES - The present invention relates to a pharmaceutical composition comprising at least one compound of formula (I) | 2013-03-28 |
20130079354 | PYRIDYL DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS - Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): | 2013-03-28 |
20130079355 | Use of Flibanserin in the Treatment of Obesity - The invention relates to a method for the treatment of obesity and related diseases comprising the administration of a therapeutically effective amount of Flibanserin. | 2013-03-28 |
20130079357 | CARBOXYLIC ACID DERIVATIVES HAVING A 2,5,7-SUBSTITUTED OXAZOLOPYRIMIDINE RING - The invention relates to oxazolopyrimidine compounds of formula (I), where A, R | 2013-03-28 |
20130079358 | CARBOXYLIC ACID DERIVATIVES HAVING A 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING - The present invention relates to oxazolopyrimidine compounds of the formula I, | 2013-03-28 |
20130079359 | NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA - The invention relates to novel piperidino-dihydrothienopyrimidine sulfoxides of formula I, | 2013-03-28 |
20130079360 | RALTEGRAVIR SALTS AND CRYSTALLINE FORMS THEREOF - The present invention includes new salts of Raltegravir and crystalline forms thereof, pharmaceutical compositions containing the salts or crystalline forms, methods of using the salts or crystalline forms or the compositions to treat HIV infection or to prepare medicament for treating HIV infection, and a process for preparing Raltegravir potassium. | 2013-03-28 |
20130079361 | NOVEL IODO PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)-IMPLICATED DISEASES AND CONDITIONS - Compounds useful for the inhibition of macrophage migration inhibitory factor (MIF) are provided herein, having the Formula (I): wherein A is selected from the group consisting of aromatic or non-aromatic rings, bicyclic rings, polycyclic rings, alkenes or alkynes; B is H, OH, OR, SR, NH2, NHR, or alkyl; R is H or alkyl, and X and Y are independently N or CH, but one of X and Y must be N. Also provided are pharmaceutical compositions comprising a Formula I compound and methods for the treatment of MIF-implicated diseases or conditions, comprising administering a safe and effective amount of a Formula I compound. | 2013-03-28 |
20130079362 | CYCLOPROPANE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES - Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including, but not limited to, malignant melanomas, solid tumors, glioblastomas, ovarian cancer, pancreatic cancer, prostate cancer, lung cancers, breast cancers, kidney cancers, hepatic cancers, cervical carcinomas, metastasis of primary tumor sites, myeloproliferative diseases, chronic myelogenous leukemia, leukemias, papillary thyroid carcinoma, non-small cell lung cancer, mesothelioma, hypereosinophilia syndrome, gastrointestinal stromal tumors, colonic cancers, ocular diseases characterized by hyperproliferation leading to blindness including various retinopathies, diabetic retinopathy, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, mastocytosis, mast cell leukemia, and diseases caused by PDGFR-α kinase, PDGFR-β kinase, c-KIT kinase, cFMS kinase, c-MET kinase, and oncogenic forms, aberrant fusion proteins and polymorphs of any of the foregoing kinases. | 2013-03-28 |
20130079363 | COMBINATIONS OF PYRIMETHANIL AND MONOTERPENES - The present invention relates to combinations of pyrimethanil, or a salt thereof, and a monoterpene, or a salt thereof, which provide an improved biocidal effect. More particularly, the present invention relates to compositions comprising a combination of pyrimethanil, or a salt thereof, together with a monoterpene selected from thymol and β-thujaplicin in respective proportions to provide a synergistic biocidal effect. Compositions comprising these combinations are useful for the protection of any living or non-living material, such as crops, plants, fruits, seeds, objects made of wood, thatch or the like, engineering material, biodegradable material and textiles against deterioration due to the action of microorganisms such as bacteria, fungi, yeasts, algae, virusses, and the like. | 2013-03-28 |
20130079365 | NEW BICYCLIC DIHYDROQUINOLINE-2-ONE DERIVATIVES - The invention provides novel compounds having the general formula (I) | 2013-03-28 |
20130079366 | Benzisoxazoles and Azabenzisoxazoles as MGLUR4 Allosteric Potentiators, Compositions, and Methods of Treating Neurological Dysfunction - Benzisoxazole and azabenzisoxazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction. | 2013-03-28 |
20130079367 | SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE- -3-CARBOXAMIDE - The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith. | 2013-03-28 |
20130079368 | SKIN IMPROVING DERMO-COSMETICS - Provided is a dermo-cosmetic composition to improve rough skin that: improves chapped or dry skin, particularly roughened cuticles; improves skin texture; results in smooth skin; and has excellent safety, stability and feel. The disclosed dermo-cosmetic is characterised by having: (A) one or more of D-amino acids, their salts and derivatives; and (B) a swollen material prepared by swelling one or more of non-emulsifying cross-linked silicone with an oil which is in a liquid form at room temperature. | 2013-03-28 |
20130079369 | METHODS FOR CONTROLLING SR PROTEIN PHOSPHORYLATION, AND ANTIVIRAL AGENTS WHOSE ACTIVE INGREDIENTS COMPRISE AGENTS THAT CONTROL SR PROTEIN ACTIVITY - The present invention provides: (1) antiviral agents that act by reducing or inhibiting the activity of SR proteins, more specifically, (i) antiviral agents that act by enhancing dephosphorylation of SR proteins, and (ii) antiviral agents that act by inhibiting proteins that phosphorylate SR proteins; (2) antiviral agents that act by inhibiting the expression of SR proteins, and (3) antiviral agents that act by activating proteins that antagonize SR proteins. The present invention also provides compounds that inhibit SRPKs, which phosphorylate SR proteins. Such compounds inhibit the activity of SR proteins and have antiviral activities. Various new viruses including SARS have emerged, and thus the present invention provides long-lasting broad-spectrum antiviral agents applicable to new viruses. | 2013-03-28 |
20130079370 | Method for the Inhibition of Deubiquitinating Activity - A method of treating in a person a cancer tumor refractory to treatment with bortezomib or an agent sharing the apoptosis generating activity of bortezomib or any other anti-cancer drug, comprises administering to the person, in a pharmaceutically acceptable carrier, a pharmacologically effective dose of an agent selected from the group consisting of b-AP15 and other proteasome inhibitor abrogating the deubiquitinating (DUB) activity of the 19S RP DUBs. | 2013-03-28 |
20130079371 | Bioadhesive Compositions of Local Anaesthetics - The present invention relates to a gelling bioadhesive pharmaceutical composition comprising one or more local anaesthetics in base form and which is suitable for topical administration. The compositions have anisotropic organic phase behaviour that admits swelling at administration site with excess water. | 2013-03-28 |
20130079372 | Substituted Phenylcarbamoyl Alkylamino Arene Compounds and N,N'-BIS-Arylurea Compounds - Substituted phenylcarbamoyl alkylamino arenes; substituted phenylthiocarbamyl alkylamino arenes; substituted phenylcarbamoyl alkylamino heteroarenes; substituted phenylthiocarbamyl alkylamino heteroarenes; N-substituted aryl, N′-substituted aryl urea compounds; N-substituted aryl, N′-substituted heteroaryl urea compounds; N-substituted aryl, N′-substituted aryl thiourea compounds and N-substituted aryl, N′-substituted heteroaryl thiourea compounds are provided and may find use as androgen receptor modulators. The compounds may find particular use in treating prostate cancer, including castration-resistant prostate cancer and/or hormone-sensitive prostate cancer. | 2013-03-28 |
20130079373 | Substituted Methanesulfonamide Derivatives as Vanilloid Receptor Ligands - The invention relates to substituted methanesulfonamide derivatives as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders. | 2013-03-28 |
20130079374 | TRICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF - The present invention provides a compound represented by the formula | 2013-03-28 |
20130079375 | MULTIHETEROARYL COMPOUNDS AS INHIBITORS OF H-PGDS AND THEIR USE FOR TREATING PROSTAGLANDIN D2 MEDIATED DISEASES - Multiheteroaryl compounds, their preparation, pharmaceutical compositions comprising these compounds, and their pharmaceutical use in the prevention and treatment of prostaglandin D | 2013-03-28 |
20130079376 | PYRIDYL-2-METHYLAMINO COMPOUNDS, COMPOSITIONS AND USES THEREOF - Compounds are provided according to formula I: | 2013-03-28 |
20130079377 | Aryl or N-heteroaryl Substituted Methanesulfonamide Derivatives as Vanilloid Receptor Ligands - The invention relates to aryl or N-heteroaryl substituted methanesulfonamide derivatives as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders. | 2013-03-28 |
20130079378 | ESTER COMPOUND AND USE THEREOF - An ester compound represented by formula (1): wherein R | 2013-03-28 |
20130079379 | GEL COMPOSITIONS OF OXYMETAZOLINE AND METHODS OF USE - Embodiments relating to gels comprising imidazoline alpha agonists, such as, without limitation, oxymetazoline or a pharmaceutically acceptable salt thereof, and methods for treating diseases, such as, without limitation, rosacea, including, for example, erythematotelangiectatic rosacea, papulopustular rosacea, phymatous rosacea, ocular rosacea or combinations thereof; and symptoms associated with rosacea, including, for example, papules, pustules, phymas (skin thickening), telangiectasias or erythema or redness associated with rosacea, other skin erythemas, telangiectasias, purpura or the like, and other manifestations associated therewith or combinations thereof using such gels are described herein. | 2013-03-28 |
20130079380 | Method and Composition for Administering Bioactive Compounds Derived From Morinda Citrifolia - This invention relates to a method and composition for providing in various health benefits by administering various bioactive compounds derived from the plant | 2013-03-28 |
20130079381 | ETOMIDATE ANALOGUES THAT DO NOT INHIBIT ADRENOCORTICAL STEROID SYNTHESIS - The invention is directed to compounds according to formula (I): where R | 2013-03-28 |
20130079382 | Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro - Compositions and methods for down modulating target gene expression with RNA interference, as well as methods for administering said compositions are disclosed. The method comprises administering a first strand to a cell, incubating the cell for a time period suitable for uptake of the first oligo prior to administering a second strand, wherein the first strand and said second strand form an intracellular duplex which is effective to catalyze degradation of gene target mRNA or inhibit translation of said mRNA. | 2013-03-28 |
20130079383 | Lipid Compounds Targeting VLA-4 - The invention relates to the compounds of formula I: | 2013-03-28 |
20130079384 | Means and Methods for Determining Risk of Cardiovascular Disease - The invention relates to medicine, in particular to internal medicine and/or cardiology. The present invention provides means and methods for typing a sample and identifying and/or treating a patient suffering from or at risk of suffering from cardiovascular disease by measuring mi RNA present in a sample of said patient. The present invention further provides means and methods for identifying new cardiovascular disease therapies. | 2013-03-28 |
20130079385 | USP47 Inhibtors and Methods to Induce Apoptosis - The present invention relates to USP47 (ubiquitin specific protease 47) inhibitors and methods for inducing apoptosis or cell death in a target cell. In certain embodiments, the invention relates to methods and kits to screen for related agents that induce apoptosis. Additionally, the invention relates to assays for screening compounds capable of acting as USP47 inhibitors. | 2013-03-28 |
20130079386 | DIAGNOSTICS OF B-CELL LYMPHOMA - The present invention relates to the fields of genetics and oncology and provides methods and means for diagnosing and monitoring of patients having B-cell lymphomas, such methods and means allowing an early diagnosis of the B-cell lymphoma. Specifically, the present invention relates to a novel method and a biomarker for diagnosing B-cell lymphomas and for differentiating the B-cell lymphomas into prognostic groups of indolent and aggressive B-cell lymphomas. | 2013-03-28 |
20130079387 | ANTISENSE OLIGONUCLEOTIDE MODULATION OF RAF GENE EXPRESSION - Oligonucleotides are provided which are targeted to nucleic acids encoding human raf and capable of inhibiting raf expression. The oligonucleotides may have chemical modifications at one or more positions and may be chimeric oligonucleotides. Methods of inhibiting the expression of human raf using oligonucleotides of the invention are also provided. The present invention further comprises methods of inhibiting hyperproliferation of cells and methods of treating or preventing conditions, including hyperproliferative conditions, associated with raf expression. | 2013-03-28 |
20130079388 | FORMULATIONS COMPRISING ANTISENSE NUCLEOTIDES TO CONNEXINS - A therapeutic and/or cosmetic formulation comprising at least one anti-sense polynucleotide to a connexin protein together with a pharmaceutically acceptable carrier or vehicle is useful in site specific down regulation of connexin protein expression, particularly in reduction of neuronal cells death, wound healing, reduction of inflammation, decrease of scar formation and skin rejuvenation and thickening. | 2013-03-28 |
20130079389 | siRNA And Their Use In Methods And Compositions For The Treatment And/Or Prevention Of Eye Conditions - The invention relates to methods and compositions for the treatment/and or prevention of eye conditions related to high levels of expression and/or activity of the vanilloid-1 receptor (TRPV). | 2013-03-28 |
20130079390 | NUCLEIC ACID MOLECULES, POLYPEPTIDES, ANTIBODIES AND COMPOSITIONS FOR TREATING AND DETECTING INFLUENZA VIRUS INFECTION - Polynucleotides and polypeptides which participate in influenza virus infection of cells and nucleic acid molecules, which include a polynucleotide sequence capable of specifically binding the polypeptides of the present invention. Also provided are methods of using such nucleic acid molecules, polynucleotides and antibodies directed thereagainst for diagnosing, treating and preventing influenza virus infection. | 2013-03-28 |
20130079391 | LIPASE INHIBITING COMPOSITION - Pharmaceutical compositions that contain a lipase inhibitor having a melting point ≧37° C., a sucrose fatty acid ester wherein the sucrose fatty acid ester is a mono-, di-, tri- or tetra-ester, and optionally one or more pharmaceutically acceptable excipients, are useful for treatment of obesity. | 2013-03-28 |
20130079392 | TLE3 AS A MARKER FOR CHEMOTHERAPY - Methods of using TLE3 as a marker for predicting the likelihood that a patient's cancer will respond to chemotherapy. Methods of using TLE3 as a marker for selecting a chemotherapy for a cancer. | 2013-03-28 |
20130079393 | ISOFLAVONE FATTY ACID ESTER DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL USES THEREOF - Isoflavone fatty acid ester derivatives of formula (I) or (II), the preparation method thereof and the pharmaceutical compositions containing such compounds are disclosed. The uses of such compounds in preparation of medicaments for preventing or treating hyperlipidemia, obesity or type II diabetes are also disclosed. | 2013-03-28 |
20130079394 | Indirect modeling of new repellent molecules active against insects, acarids, and other arthropods - This invention relates to novel coumarin derivatives, formulations comprising same, and to methods of making and using these compounds and formulations, which are useful as repellents against insects and/or pests. The compounds also prevent illness and disease caused by insect/pest-borne vectors, and provide safer, more effective alternatives to existing repellents. This invention also relates to novel methods for modeling and/or predicting the repellency of unknown compounds. | 2013-03-28 |
20130079395 | NOVEL PROCESS - The present invention provides a process for the production of an oil in water emulsion comprising the step of a) introducing an oil phase into a mixing device by applying a positive pressure in the oil phase containing tank. | 2013-03-28 |
20130079396 | Anticancer and Tubulin Polymerisation Inhibition Activity of Benzylidene Indanones and Process of Preparing the Same - The present invention relates to benzylidene indanones of general formula 1. The compounds exhibited tubulin polymerisation inhibition. A series of compounds 2-benzylidene 3-(3,4,5-trimethoxyphenyl) indanones having general formulae | 2013-03-28 |
20130079397 | PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE AMINE DERIVATIVES - An industrial process for production of high-purity optically active amine derivatives in high yield while inhibiting the formation of by-products, which comprises subjecting (E)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-ylidene)ethylamine to asymmetric reduction, catalytically reducing the obtained product at a reaction temperature of 40 to 100° C. and a pH of 3 to 9, subjecting the obtained (S)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine to propionylation, and then crystallizing the reaction mixture. | 2013-03-28 |
20130079398 | PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING NERVOUS SYSTEM DISORDERS COMPRISING SULFURETIN OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF - The present invention relates to a pharmaceutical composition for preventing or treating nervous system disorders, which contains sulfuretin or a pharmaceutically acceptable salt thereof, and a method of using the composition to prevent or treat nervous system disorders. Moreover, the present invention relates to a functional food composition for alleviating nervous system disorders, which contains sulfuretin or a pharmaceutically acceptable salt thereof. The pharmaceutical composition and the functional food composition can be effectively used to prevent or treat degenerative brain disorders caused by a variety of cerebral nervous system abnormalities in persons, as well as depressive disorder and anxiety. | 2013-03-28 |
20130079399 | NOVEL DERIVATIVES OF MESALAZINE, PROCESS OF THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF INTESTINAL INFLAMMATORY DISEASES - The present invention refers to the compounds corresponding to the following general formula (I): | 2013-03-28 |
20130079400 | PROCESS FOR THE PREPARATION OF PLEUROMUTILINS - Process for the preparation of a compound of formula I | 2013-03-28 |
20130079401 | NOVEL USE OF ISOTHIOCYANATES FOR TREATING CANCER - Novel Uses of small molecules, particularly, 6-methylsulfinylhexyl isothiocyanate and 6-methylsulfonylhexyl isothiocyanate, are disclosed herein. The two isothiocyanates are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating cancer, particularly drug-resistant cancer, in a patient. | 2013-03-28 |
20130079402 | Use of at Least One Dialkyl Thiosulfonate or Thiosulfinate for Reducing the Number of Apicomplexa in an Animal - The invention relates to the use of at least one dialkyl thiosulfonate or thiosulfinate in order to reduce the number of apicomplexa, such as coccidioides and, in particular, | 2013-03-28 |
20130079403 | RETINAL DERIVATIVES AND METHODS FOR THE USE THEREOF FOR THE TREATMENT OF VISUAL DISORDERS - Compositions of and methods for using synthetic retinal derivatives as retinoid replacements and opsin agonists are provided. | 2013-03-28 |
20130079404 | TOPICAL FORMULATION - It has been discovered that certain combinations of compounds are excellent penetration enhancers and, as such, can be incorporated in a topical formulation to facilitate administration of active agents. The increased penetration enhancement can also lead to a reduction in the total concentration of skin irritants in the formulation. There is described herein a topical formulation comprising (i) an active agent selected from at least one of lidocaine and tetracaine; (ii) a first compound, and (iii) a second compound, wherein the first compound and second compound are different, and each is selected from the group consisting of N-lauroyl sarcosine, sodium octyl sulfate, methyl laurate, isopropyl myristate, oleic acid, glyceryl oleate and sodium lauryl sulfoacetate. | 2013-03-28 |
20130079405 | Hydroxy Acid Ester Compound of Substituted Phenol, Preparation Method and Medical Use Thereof - Hydroxy acid compound of substituted phenyl ester, preparation method and medical use thereof are provided. The title compound is shown in formula (I), Y═C | 2013-03-28 |
20130079406 | THERAPEUTIC COMPOSITIONS - Compositions comprising ketone bodies and/or their metabolic precursors are provided that are suitable for administration to humans and animals and which have the properties of, inter alia, (i) increasing cardiac efficiency, particularly efficiency in use of glucose, (ii) for providing energy source, particularly in diabetes and insulin resistant states and (iii) treating disorders caused by damage to brain cells, particularly by retarding or preventing brain damage in memory associated brain areas such as found in Alzheimer's and similar conditions. | 2013-03-28 |
20130079407 | ANTIMICROBIAL COMPOSITION AND METHODS FOR USING SAME - An aqueous composition adapted to kill bacteria in both planktonic and biofilm states is lethal toward a wide spectrum of gram positive and gram negative bacteria as well as other microbes. The composition, which is slightly to moderately acidic, includes a significant amount of one or more surfactants and large amounts of osmotically active solutes. The composition can be applied directly to a site of bacterial growth. Even when the bacteria is in biofilm form, the surfactant component(s) begin to kill the bacteria before the macro-molecular matrix is removed or dislodged from the site. | 2013-03-28 |
20130079408 | PERACID AND 2-HYDROXY ORGANIC ACID COMPOSITIONS AND METHODS FOR TREATING ITEMS - Methods and compositions for treating items to control microorganisms are provided. The method treats produce by contacting the surface of the item with an aqueous composition comprising i) an organic peracid of the formula RC(O)OOH wherein R is methyl, ethyl, n-propyl, or s-propyl; ii) a 2-hydroxy organic acid selected from tartaric acid, citric acid, malic acid, mandelic acid, and lactic acid; and iii) water; wherein the aqueous composition has a pH from 2.5 to 6.0. | 2013-03-28 |
20130079409 | STABLE PHARMACEUTICAL COMPOSITION AND METHODS OF USING SAME - The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular-related diseases. | 2013-03-28 |
20130079410 | OIL-IN-WATER TYPE EMULSION SKIN COSMETIC - An oil-in-water type emulsion skin cosmetic which can be spread on skin easily. The formulation can contain glycerin at a high concentration or a formulation containing a combination of glycerin and an acrylamide-type thickening agent without the sticky effect. The skin cosmetic is characterized by comprising (A) a D-amino acid or a derivative or salt thereof, (B) a homopolymer, a copolymer or a crosspolymer containing at least one component selected from 2-acrylamide-2-methylpropanesulfonic acid, acrylic acid and derivatives thereof as a constituent unit, (C) an ester oil with an IOB value of 0.2 to 0.6, and (D) glycerin. | 2013-03-28 |
20130079411 | METHOD FOR PREVENTING OR TREATING A DISEASE, DISORDER OR CONDITION INDUCED BY RETINA ISCHEMIA - The present invention provides a method for preventing or treating a disease, disorder or condition induced by retina ischemia, comprising administering to a subject in need thereof a S-allyl-L-cysteine in a therapeutically effective amount. | 2013-03-28 |
20130079412 | Branched 3-phenylpropionic acid derivatives and their use - The present application relates to novel 3-phenylpropionic acid derivatives which carry a branched or cyclic alkyl substituent in the 3-position, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases. | 2013-03-28 |
20130079413 | Crystalline Diacylhydrazine and the Use Thereof - The present disclosure provides crystalline polymorphic and amorphous forms of (R)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(2-ethyl-3-methoxy-benzoyl)-hydrazide (Compound 1) or (S)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(2-ethyl-3-methoxy-benzoyl)-hydrazide (Compound 2). The present disclosure further provides compositions comprising crystalline polymorphic and amorphous forms of Compound 1 or Compound 2 and an excipient, methods of making crystalline polymorphic or amorphous forms of Compound 1 or Compound 2, and methods of using crystalline polymorphic or amorphous forms of Compound 1 or Compound 2 to regulate gene expression in a cell or in a subject. | 2013-03-28 |
20130079414 | ENHANCED BIMATOPROST OPHTHALMIC SOLUTION - A composition comprising from 0.005% to 0.02% bimatoprost by weight and from 100 ppm to 250 ppm benzalkonium chloride, wherein said composition is an aqueous liquid which is formulated for ophthalmic administration is disclosed herein. A method which is useful in treating glaucoma or ocular hypertension related thereto is also disclosed herein. | 2013-03-28 |
20130079415 | COMPOSITIONS COMPRISING AMPHETAMIN AND LISDEXAMFETAMINE - A formulation comprising dexamphetamine and lys-dexamphetamine useful in the treatment of ADHD or fatigue. | 2013-03-28 |
20130079416 | HOMEOPATHIC MEDICAMENT COMPRISING PHENACETIN FOR THE TREATMENT OF CANCER - The present invention relates to a composition comprising phenacetin, in particular a Phenacetinum 4CH homeopathic medicament for use in the treatment of cancer. | 2013-03-28 |
20130079417 | Highly Selective 5-HT(2C) Receptor Agonists That Show Anti-Psychotic Effects with Antagonist Activity at the 5-HT(2B) Receptor - Highly selective 5-HT(2C) receptor agonists receptors are disclosed. The 5-HT(2C) receptor agonists are used in the treatments of disease and conditions wherein modulation of 5-HT(2C) receptors provides a benefit, such as obesity and psychiatric disorders. | 2013-03-28 |
20130079418 | Phoshorylation of Estrogen Receptor Alpha Serine 282 as a Marker for Endocrine Therapies in Breast Cancer - The present invention provides diagnostic methods and markers based on the phosphorylation state of certain amino acid residues of estrogen receptor α. The invention relates to the phosphorylation of specific estrogen receptor alpha residues as a marker for susceptibility to chemotherapy. The invention specifically discloses the phosphorylation of serine 282 of the ER-alpha, as a diagnostic marker for breast cancer cells which are more responsive to hormone therapy than cells without the said phosphorylation. | 2013-03-28 |
20130079419 | HIGH SOLVENT CONTENT EMULSIONS - A high solvent content emulsion having solvent, functionalized polymer and particles having an isoelectric point below the pH of the emulsion is described. The emulsion yields excellent sensory and deliverability benefits and is suitable for use as a carrier for consumer-based end use compositions. | 2013-03-28 |
20130079420 | NOVEL THICKENING POLYMER FOR IONIC OIL PHASES FREE OF MONOMERS - A copolymer that includes for 100 mol %: a) more than 70 mol % and up to 99.9 mol % of hydrophobic monomer units (A) from stearyl methacrylate; and b) 0.1 mol % to 30 mol % of monomer units (B) from at least one monomer of a compound of formula (I) where R1 is a linear or branched alkyl radical comprising 12 to 22 carbon atoms, R2 is a hydrogen atom or a methyl radical, and n is an integer greater than or equal to 0 and lower than or equal to 30, wherein it is understood that said compound of formula (I) is not stearyl methacrylate. The invention also relates to a method for preparing and using same as a modifier of the rheology of the oil phase of a topical cosmetic, dermopharmaceutical, or pharmaceutical composition. | 2013-03-28 |
20130079421 | MALLEABLE HYDROGEL HYBRIDS MADE OF SELF-ASSEMBLED PEPTIDES AND BIOCOMPATIBLE POLYMERS AND USES THEREOF - Hybrid hydrogels formed of a plurality of peptides that are capable of self-assembling into a hydrogel in an aqueous solution and a biocompatible polymer that is characterized by high swelling capability, high elasticity and low mechanical strength are disclosed, with exemplary hybrid hydrogels being formed of a plurality of aromatic dipeptides and hyaluronic acid. The hybrid hydrogels are characterized by controllable mechanical and biological properties which can be adjusted by controlling the concentration ratio of the peptides and the polymer, and which average the mechanical and biological properties of the peptides and the polymer. Processes of preparing the hydrogels and uses thereof in pharmaceutical, cosmetic or cosmeceutic applications such as tissue engineering and/or regeneration are further disclosed. | 2013-03-28 |
20130079422 | OPHTHALMIC CONTACT LENS SOLUTIONS CONTAINING FORMS OF VITAMIN B - The present invention relates to improved ophthalmic solutions that employ select B vitamins; pyridoxine and its salts; and thiamine and its salts in order to more effectively preserve solutions and to reduce the degree to which cationic preservatives will deposit on contact lenses. Ophthalmic solutions are here understood to include contact lens treatment solutions, such as cleaners, soaking solutions, conditioning solutions and lens storage solutions, as well as wetting solutions and in-eye solutions for treatment of eye conditions. | 2013-03-28 |
20130079423 | DIAGNOSTIC METHODS INVOLVING LOSS OF HETEROZYGOSITY - The invention relates generally to methods of molecular analysis and particularly to methods of using genetic copy number variations and loss of heterozygosity in the characterization and treatment of disease. | 2013-03-28 |
20130079424 | METHODS FOR IDENTIFYING LEUKEMIA STEM CELLS AND DISTINGUISHING THEM FROM NORMAL HEMATOPIETIC STEM CELLS IN PATIENTS WITH ACUTE MYELOID LEUKEMIA: USES IN DIAGNOSIS, TREATMENT, AND RESEARCH - Using the methods of the present invention, intermediate (int) levels of aldehyde dehydrogenase (ALDH) activity reliably distinguished leukemic CD34 | 2013-03-28 |
20130079425 | Urokinase-Type Plasminogen Activator Protein /Plasminogen Activator Inhibitor Type-1 Protein Selected Reaction Monitoring Assay - Specific peptides are provided that are derived from subsequences of the urokinase-type plasminogen activator protein and the plasminogen activator inhibitor type-1 protein along with assays that can measure those peptides directly in complex protein lysate samples, including protein lysates prepared from histologicaly-processed formalin fixed tissue. The presence and amount of those peptides in samples from a subject can be associated with disease, including cancer, in a subject and provide information about the diagnostic stage/grade/status of the disease/cancer. | 2013-03-28 |
20130079426 | CARBON NEUTRAL NATURAL GAS TO LIQUIDS PLANT WITH BIOMASS CO-FEED - Configurations, systems, and methods for a gas-to-liquids plant are presented in which the energy demand for natural gas reformation is provided at least in part by biomass gasification to reduce or eliminate net carbon emissions. Preferred plants, systems, and methods may recycle various process streams to further reduce water demand, improve the hydrogen/carbon ratio of a feed stream to a Fischer-Tropsch process, and recover and/or recycle carbon dioxide. | 2013-03-28 |
20130079427 | POLYARYLENE COMPOSITIONS FOR DOWNHOLE APPLICATIONS, METHODS OF MANUFACTURE, AND USES THEREOF - A crosslinked product of a polyarylene is disclosed, having high-temperature elastomeric properties and excellent chemical resistance. The crosslinked materials are useful in oil and gas downhole applications in the form of either solids or foams. Methods for the manufacture of the crosslinked product and articles comprising the product are also disclosed. | 2013-03-28 |
20130079428 | METHODS FOR MAKING A FOAMED ADHESIVE CONTAINING CLOSED CELLS - Methods for making foamed adhesive compositions suitable for use in adhesive dressings for topical application to the body, the method including providing a molten adhesive composition, combining an inert gas with the molten adhesive composition in a first mixer, mixing the molten adhesive composition comprising the inert gas in the first mixer under conditions effective to form a first foamed adhesive composition; and mixing the first foamed adhesive composition in a second mixer that includes a rotating mixing blade under conditions effective to provide a second foamed adhesive composition having a substantially homogenous distribution of closed cells containing the inert gas. | 2013-03-28 |
20130079429 | PROCESS FOR THE PRODUCTION OF HIGH AIR FLOW POLYETHER FOAMS AND THE FOAMS PRODUCED BY THIS PROCESS - This invention relates to novel polyol blends, a process for preparing foams with very low resistance to air flow from certain polyol blends and to the resultant foams. The polyol blends comprise one or more monofunctional polyethers having a hydroxyl number of less than 28; one or more polyether polyols having a hydroxyl number of 20 to 240 and containing at least 50% of copolymerized oxyethylene; one or more polyether polyols having a hydroxyl number of 47 to 300 and containing from 5 to 40% of copolymerized oxyethylene; and optionally, one or more polyether polyols having a hydroxyl number of 10 to 45. This process of the invention comprises reacting one or more polyisocyanates, with an isocyanate-reactive component which comprises a specific polyol blend, in the presence of at least one catalyst, at least one surfactant and at least one blowing agent. | 2013-03-28 |
20130079430 | RESIN COMPOSITION FOR POLYOLEFIN RESIN FOAM, POLYOLEFIN RESIN FOAM AND FOAMED SEALING MATERIAL - The present invention relates to a resin composition for a polyolefin resin foam, including: a polyolefin (A) having a melt flow rate (MFR) at a temperature of 230° C. of 0.2 to 0.7 g/10 min and a melt tension at break measured at a temperature of 190° C. of 30 cN or more; and a polyolefin (B) having a melt flow rate (MFR) at a temperature of 230° C. of 1.5 to 10 g/10 min and a melt tension at break measured at a temperature of 190° C. of 10 cN or more, in which the polyolefin (B) is contained in an amount of from 15 to 75 parts by weight based on 100 parts by weight of the polyolefin (A). | 2013-03-28 |
20130079431 | Single layer flexible foam including polyurethane gel - A single layer flexible foam includes the reaction product of an (A) isocyanate component and a (B) isocyanate-reactive component. The isocyanate component and the isocyanate-reactive component react in the presence of a (C) polyurethane gel. The polyurethane gel has a viscosity of from about 3,000 to about 12,000 cps at 25° C. and includes the reaction product of a polyol component and a second isocyanate component which react at an isocyanate index of from about 10 to about 70. The flexible foam also includes a plurality of agglomerated gel substrates that are formed from the polyurethane gel and that are dispersed in the flexible foam. The flexible foam is formed using a method including the steps of providing (A), providing (B), providing (C), and combining (C) with (A) and (B), such that (A) and (B) react in the presence of (C) to form the flexible foam. | 2013-03-28 |
20130079432 | POLYARYLENE COMPOSITIONS, METHODS OF MANUFACTURE, AND ARTICLES THEREOF - A crosslinked product of a polyarylene is disclosed, having high-temperature elastomeric properties and excellent chemical resistance. The crosslinked materials are useful in oil and gas downhole applications in the form of either solids or foams. Methods for the manufacture of the crosslinked product and articles comprising the product are also disclosed. | 2013-03-28 |
20130079433 | NOVEL MATTING AGENTS FOR UV OVERPRINT VARNISHES - The invention relates to matted UV overprint varnishes comprising silicon dioxides, the surface of which has been modified by means of treatment with an organopolysiloxane containing multiple bonds so as to be particularly well suited for use as matting agents for UV varnishes and printing inks. The invention also relates to a method for producing said varnishes. | 2013-03-28 |
20130079434 | PROCESS FOR MANUFACTURING A PART MADE OF A COMPOSITE HAVING A HOLLOW CORE - A method for manufacturing a part in composite material with a hollow core is provided that includes applying at least one adhesive layer on an open surface of the hollow core. The adhesive layer is a blocking polymerizable adhesive layer having, after polymerization, sealing properties relatively to a resin and capable of preventing its diffusion towards an inside of the hollow core. Subsequently, the blocking adhesive layer is polymerized so as to achieve sealing of the hollow core. Additionally, various parts manufactured according to the methods of the present disclosure are also provided. | 2013-03-28 |
20130079435 | Benzylated Polyamine Curing Agents - A curing agent composition including at least one benzylated polyamine compound. The benzylated polyamine compound is a reaction product of a benzaldehyde compound or benzyl halide compound and a polyamine according to the following formula: | 2013-03-28 |
20130079436 | CURING OF EPOXY RESIN COMPOSITIONS COMPRISING CYCLIC CARBONATES USING MIXTURES OF AMINO HARDENERS - A process for curing an epoxy resin composition containing an epoxy resin and a compound of the general formula I: | 2013-03-28 |
20130079437 | EPOXIDE/(METH) ACRYLATE COMPOSITION - A composition having at least one radically polymerisable monomer M; at least one radical former, at least one epoxide resin A including an average of more than one epoxide group per molecule, and at least one compound of formula (I). Such compositions are suitable as adhesives, sealants or coatings. Shortly after the application thereof, they have a high initial strength and, after further hardening at room temperature, they reach a high level of final strength. | 2013-03-28 |
20130079438 | BLENDS OF POLYETHERIMIDE SULFONE AND POLY(ARYLENE SULFIDE) - Disclosed herein is a composition comprising a compatible blend of i) 60 to 85 weight percent of a linear poly(arylene sulfide), ii) 15 to 40 weight percent of a polyetherimide sulfone; and iii) 1 to 3 weight percent of a novolac resin having an average of 2 or more epoxy groups per molecule. Weight percent is based on the total weight of the composition. An article made from the composition has a tensile strength greater than or equal to 70 megaPascals (MPa), as determined by ASTM D638, an impact strength of greater than or equal to 3 kiloJoules per square meter (kJ/m | 2013-03-28 |
20130079439 | COMPOSITE MATERIAL MADE OF A MATERIAL CONTAINING CELLULOSE AND A PLASTIC MATERIAL - The invention relates to novel composite materials which are made of at least one material containing cellulose, preferably wood, and at least one plastic material, and which have improved mechanical and weather resistance properties. | 2013-03-28 |
20130079440 | COPOLYESTER BLENDS WITH ENHANCED TEAR STRENGTH - This invention relates to aliphatic-aromatic copolyesters that can exhibit improved tear strength and improved rate of biodegradation. Particularly to an aliphatic-aromatic copolyester having a dicarboxylic acid component and a glycol component. The invention also relates to articles and blends using the copolyesters. | 2013-03-28 |
20130079441 | STARCH/RUBBER LATEX COMPOUND AND METHOD FOR MANUFACTURING SAME USING COUPLING REAGENT - Disclosed is a rubber composition obtained by chemically blending rubber with a filler, particularly in which Latex rubber is directly blended with a starch solution obtained by gelatinizing starch in water. Herein, as a coupling agent between Latex rubber and starch, resorcinol-formaldehyde is used. By this, a vulcanized rubber compound is prepared. When resorcinol-formaldehyde is used as a coupling agent during the blending of the Latex rubber with the gelatinized starch solution, it is possible to solve the problem of tensile strength lowering caused by low affinity with rubber. Furthermore, it is possible to inhibit starch loss caused by high water-solubility, during the blending of starch in a liquid state. Also, the physical property of the vulcanized rubber compound can be varied according to the amount of the added coupling agent. | 2013-03-28 |
20130079442 | BLUE INK FOR POSTAGE PRINTING - A blue ink for postage printing, which contains a blue pigment, a black dye, and an aqueous carrier, wherein the weight ratio of blue pigment to black dye is in the range of 50:1 to 2:1. The blue pigment is a copper phthalocyanine pigment or an anthraquinone pigment, and the black dye is an azo dye. | 2013-03-28 |
20130079443 | FLAME-RETARDANT PC/ABS COMPOSITIONS HAVING GOOD IMPACT STRENGTH, FLOWABILITY AND CHEMICAL RESISTANCE - The present invention relates to flame resistant moulding compositions comprising polycarbonates and graft polymers which, in addition to good flow properties, exhibit good (notched) impact strength and high chemical resistance with a UL94V-0 classification at 1.5 mm. These moulding compositions are particularly suitable for thin-walled housing parts in the electrical and electronics sector. | 2013-03-28 |
20130079444 | NOVEL PROCESS FOR THE PREPARATION OF CARBON BLACK/SILICA/NANOCLAY MASTER BATCH FROM FRESH NATURAL RUBBER LATEX - The present invention relates to a process for preparing tri-filler incorporated natural rubber master batch. The fillers used in the present invention are carbon black, silica and nano-clay (modified montmorillonite clay, Cloisite 93 A). The process of preparing fillers incorporated master batch involves preparation of the individual filler dispersions by mixing each filler with surfactants. Further fresh rubber latex is soap sensitized by mixing it with surfactant. The filler dispersions are added to the soap sensitized rubber latex slowly under stirring to form the master mix. Then the master mix is coagulated by the addition of acid to form coagulum. The coagulum is dewatered and dried to obtain filler incorporated natural rubber master batch. | 2013-03-28 |