12th week of 2009 patent applcation highlights part 44 |
Patent application number | Title | Published |
20090075212 | Immersion lithography fluid control system - An immersion lithography apparatus includes an optical member, a gap defined between the optical member and a surface disposed opposite the optical member being filled with an immersion liquid, and a fluid control device including a gas outlet through which a gas is supplied to prevent the immersion liquid from entering a surround area external to an exposure area. A flow velocity of the gas supplied from the gas outlet depends on a contact angle between the immersion liquid and the surface. | 2009-03-19 |
20090075213 | Method of forming an auto-calibration label using a laser - An auto-calibration circuit or label ( | 2009-03-19 |
20090075214 | MANUFACTURING METHOD OF LIGHT EMITTING DEVICE, AND EVAPORATION DONOR SUBSTRATE - An object is to provide a manufacturing method of a light emitting device, by which manufacturing costs in manufacturing a flat panel display can be reduced. A first substrate provided with a reflective layer having an opening over a first surface, and provided with a light absorption layer and an evaporation material over a second surface facing the first surface is used. Then, in a state where the second surface of the first substrate is disposed close to a first surface of a second substrate, light irradiation is performed from the first surface side of the first substrate. The irradiation light is absorbed by a portion of the light absorption layer overlapping with the opening in the reflective layer, thereby heating the evaporation material. The heated evaporation material is attached to the first surface of the second substrate. | 2009-03-19 |
20090075215 | Photoplate for oled deposition screen - A photoplate for manufacturing a deposition mask that is used to form a matrix of pixel areas used in a display panel. The photoplate comprises a layer of material such as quartz, on which a matrix of pixel etching areas is defined. The pixel etching areas are configured to form pixel areas having a specified separation from each other in a vertical direction. The pixel etching areas on the photoplate include an outer periphery having a generally rectangular shape with elongated corners. | 2009-03-19 |
20090075216 | STORAGE MEDIUM STORING EXPOSURE CONDITION DETERMINATION PROGRAM, EXPOSURE CONDITION DETERMINATION METHOD, EXPOSURE METHOD, AND DEVICE MANUFACTURING METHOD - A computer-readable storage medium storing a program for causing a computer to execute determination of an exposure condition for use in illuminating an original plate with an illumination optical system and projecting an image of a pattern of the original plate onto a substrate through a projection optical system. The program causes the computer to perform operations including setting a light intensity distribution on a pupil plane in the illumination optical system based on a constraint condition concerning an optical element constituting the illumination optical system, calculating the image of the pattern of the original plate to be projected onto the substrate using the light intensity distribution, and determining the exposure condition for exposing the substrate with the image of the pattern of the original plate based on a calculation result of the image of the pattern of the original plate and the constraint condition. | 2009-03-19 |
20090075217 | TAPERED EDGE BEAD REMOVAL PROCESS FOR IMMERSION LITHOGRAPHY - A method and apparatus for forming a tapered photoresist edge. The method includes: forming a photoresist layer on a substrate; exposing a first annular region of the photoresist layer adjacent to a perimeter of the substrate to actinic radiation, the first annular region having a first outer perimeter proximate to a perimeter of the substrate and a first inner perimeter away from the perimeter of the substrate, the actinic radiation gradually decreasing in intensity from the first outer perimeter to the first inner perimeter; and developing the exposed first annular region of the photoresist layer to form a tapered profile in a second annular region of the photoresist layer, the second annular region having a second perimeter proximate to the perimeter of the substrate and a second inner perimeter away from the substrate perimeter, the profile gradually increasing in thickness from the second outer perimeter to the second inner perimeter. | 2009-03-19 |
20090075218 | SILVER HALIDE COLOR PHOTOGRAPHIC LIGHT-SENSITIVE MATERIAL - A silver halide color photographic light-sensitive material, in which at least one of silver halide emulsion layers contains a silver halide emulsion having a silver chloride content of at least 90 mol % and being chemically sensitized with at least one compound of formula (1): | 2009-03-19 |
20090075219 | Oxycombustion Method Allowing Capture of All of the Carbon Dioxide Produced - The invention relates to an oxycombustion method with capture of the CO | 2009-03-19 |
20090075220 | Combustion Apparatus for Operation With a Liquid Fuel - A combustion apparatus for operation with a fuel which is liquid at room temperature, in particular with a vegetable oil, wherein the combustion apparatus includes an evaporator device for evaporating the liquid fuel and a nozzle for ejection and for flame ignition of the evaporated fuel. The evaporator device is disposed in fluid communication with a fuel tray for preheating the evaporator device for a start of operation. | 2009-03-19 |
20090075221 | GAS BURNING HAND TOOL | 2009-03-19 |
20090075222 | Particulate mitigating propellant management tank device - A propellant management device comprising a plurality of insert vanes with respective outwardly extending curved flanges is disposed in a propellant tank with the curved flanges having mating contact along contacting lines on the interior of the tank as the insert vanes serves to wick fuel within the tank with reduced particulate generation within the tank for improved reliability and use of the propellant tank. | 2009-03-19 |
20090075223 | BURNER APPARATUS - A burner assembly includes a fuel nozzle and an air-fuel mixing cone coupled to the fuel nozzle. Fuel is discharged from the fuel nozzle into a mixing chamber formed in the air-fuel mixing cone. Air passes into the mixing chamber through openings formed in the air-fuel mixing chamber and mixes with fuel to form a combustible air-fuel mixture in the air-fuel mixing chamber. | 2009-03-19 |
20090075224 | CONVEYOR OVEN APPARATUS AND METHOD - An oven according to some embodiments includes an oven chamber in which food is cooked, a heating element, a fan, a sensor for sensing the temperature of the oven chamber, a remote input device, and a controller configured to receive a signal from the remote input device and to change the fan or heating element based at least in part upon the signal received from the remote input device. In a method of operating the oven according to some embodiments, the oven enters an operating mode from an energy-savings mode responsive to receiving an signal from a remote device. | 2009-03-19 |
20090075225 | HEATING APPARATUS AND HEATING METHOD - A heating apparatus has first through fifth heating furnace arranged along the feeding direction in which glass substrates are fed by a feeding mechanism. The first heating furnace has a first heater for heating a glass substrate to at least a target temperature required for processing the workpiece. The second heating furnace has a heater for heating a glass substrate to a temperature equal to or below the target temperature. The second heating furnace generates an amount of heat smaller than that of the first heating furnace. | 2009-03-19 |
20090075226 | ORTHODONTIC BRACKETS - Polymeric resin matrix phase (thermoplastic, thermosetting or biomass) is reinforced with fiber filament or fine particles to enhance the mechanical properties (particularly, bending strength and bending stiffness), impact strength while keeping its original transparency. Plastic brackets (either previously reinforced as mentioned above or un-reinforced) can be surface-treated by plasma coating with thin film or simply ultra violet radiation to enhance the surface mechanical properties as well as anti-frictional force against the archwire's movement while again maintaining its transparency. Accordingly, the present invention can provide orthodontic brackets made of plastics with high mechanical strengths and clearness, so that aesthetic appearance is improved. | 2009-03-19 |
20090075227 | ORTHODONTIC BRACKET AND CLIP RELEASE TOOL - A clip release tool with a first and second projection, for releasing a clip from a main bracket body of an orthodontic bracket while regulating movement or deformation of the clip, and a related method, and a method of attaching a clip to an orthodontic bracket main body using a clip release tool. | 2009-03-19 |
20090075228 | DENTAL OBSERVATION APPARATUS - Caries located at a position that cannot be directly viewed, such as one of the adjacent surfaces between teeth, can be observed with high contrast, and the spread and the degree of invasion of the caries can be observed. A dental observation apparatus has: an irradiating unit radiating illumination light including an infrared region; a detecting unit separately detecting fluorescence generated from a caries portion by irradiation with the illumination light and scattered light of the illumination light at the tooth; and an image processing unit which forms a fluorescence image based on the fluorescence detected by the detecting unit, which forms a scattered light image capable of identifying a boundary between an enamel layer and a dentine layer, the layers having different scattering properties, based on the intensity of the scattered light detected by the detecting unit, and which combines the fluorescence image and the scattered light image. | 2009-03-19 |
20090075229 | PROBES AND BIOFLUIDS FOR TREATING AND REMOVING DEPOSITS FROM TISSUE SURFACES - An endodontic probe is used to perform disinfection procedures on target tissues within root canal passages and tubules. The endodontic probe can include an electromagnetic radiation emitting fiber optic tip having a distal end and a radiation emitting region disposed proximally of the distal end. According to one aspect, the endodontic probe can include a porous structure that encompasses a region of the fiber optic tip excluding the radiation emitting region and that is loaded with biologically-active particles, cleaning particles, biologically-active agents, or cleaning agents for delivery from the porous structure onto the target tissues. Another aspect can include provision of the endodontic probe with an adjustable channel-depth indicator, which encompasses a region of the fiber optic tip besides the radiation emitting region and which is movable in proximal and distal directions along a surface of the fiber optic tip to facilitate the provision of depth-of-insertion information to users of the endodontic probe. | 2009-03-19 |
20090075230 | Teething ring - A dental device has a U-shaped carrier with at least one channel for embracing an arch of teeth. The carrier has recessed insets in the channel. Discrete inserts carrying a beneficial agent can fit into the insets and release the agent gradually. When the device is used in a primarily therapeutic application, the inserts may be installed into all or less than all of the insets to form various insert patterns. Thus, different oral regions can be affected by different insert patterns. When the device is used as an athletic mouthguard, temporary blanks may be initially fitted in the insets, while a portion of the mouthguard is softened before an arch of teeth is pressed into the channel to make a custom impression. The inserts that are later installed in the insets possess different physical properties than the carrier and may be positioned and shaped to mechanically buffer teeth of the arch from mechanical shocks as well as release beneficial agents. The inserts may be replaced or refreshed to maintain the beneficial agent, which may be xylitol, remineralizing agents, moisturizing agents, desensitizing agents, flavoring agents, breath fresheners, chemical and biological indicators, nutraceuticals, antibiotics, probiotics, other medications and chemotherapeutics, or other agents. | 2009-03-19 |
20090075231 | DENTAL/MEDICAL ORAL IRRIGATION SYSTEM - A method and device delivers a medicament to a selected tissue for treatment of the tissue, plaque and biofilm included. In the device, a first reservoir member is used to connect to a fluid source. Further, a second reservoir member engages the first reservoir member to define a chamber for receiving the medicament. Structurally, the second reservoir member includes an outlet. Attached to the outlet is a tube that extends to a nozzle. When connected, the first reservoir member, second reservoir member, and tube define a passageway from the fluid source to the nozzle. During use, a flow rate for a fluid is established through the passageway to deliver the medicament from the passageway through the nozzle to the selected tissue. | 2009-03-19 |
20090075232 | COUPLING SYSTEM FOR HAND INSTRUMENTS FOR DENTAL OR SURGICAL USE - A coupling system for shafts of the lower gripper mechanism and the upper motor mechanism of an instrument includes: —a hollow shaft whose upper end can couple to the lower end of the motor mechanism shaft and whose lower end can slide around the upper end of the gripper mechanism shaft; a movable pin connecting the lower end of the hollow shaft with the upper end of the gripper mechanism shaft; a spring; two diametrically opposed oblong windows serving to limit the path of the pin such that, for the hollow shaft and the gripper mechanism shaft, a first relative position wherein they are separated maximally and a second relative position wherein they are approached maximally are defined; and a holder whose length is such that, only in the second position, it allows the pin to appear allowing connection separation of the coupling system and the gripper mechanism, respectively. | 2009-03-19 |
20090075233 | SINGLE-USE HIGH-SPEED TURBINE DENTAL DRILL HANDPIECE - A single use high-speed turbine dental drill handpiece, comprising: a head ( | 2009-03-19 |
20090075234 | PERIODONTAL SURGERY OPERATION METHODS AND INSTRUMENTS - The present invention relates generally to methods of performing periodontal surgeries, and instruments for performing said surgeries. A method of performing periodontal surgery to correct a gingival defect of a patient according to a general embodiment comprises the steps of making an incision at or near a fornix of the patient near the gingival defect, inserting an instrument into the incision to detach a flap, advancing the flap horizontally without enlarging the incision, elevating a papilla within the flap, stretching the flap to cover the gingival defect, and pressing against the flap to promote fibrin formation. An instrument for performing periodontal surgery according to one general embodiment comprises a handle, a first shank connecting to and extending from the handle, a connector section, and a blade section. The connector section further comprises a first end and a second end, wherein the first end connects to the first shank at a first angle, and the second end connects to the blade section at a second angle. Further, the blade section is approximately perpendicular to a plane formed by the handle and the connector section, and a cutting surface of the blade section is parallel to the second end of the connector section. | 2009-03-19 |
20090075235 | Fixed, Implant-Supported, Full Arch Dental Prosthetics and Methods of Seating Thereof - A fixed, implant-supported, full arch dental prosthetic having a dental prosthetic body, a rigid fence and a gingival veneer. The dental prosthetic body is prefabricated from a cured dental resin, and the rigid fence and the gingival veneer are respectively constructed from a curable dental resin. The dental prosthetic body, which can be included in a dental kit, may be prefabricated in various shapes and sizes and with various tooth forms. The dental kit also contains a supply of at least one curable dental resin, such as for constructing the rigid fence and/or the gingival veneer of the dental prosthetic and/or for affixing the dental prosthetic to an array of dental implants embedded in a patient's mouth. | 2009-03-19 |
20090075236 | DENTAL IMPLANT HAVING IMPROVED STABILITY - A dental implant system employs an improved abutment screw with acceptable biocompatibility, corrosion, strength, and preload characteristics. In particular, embodiments provide a dental implant system having an artificial implant and an abutment which are fastened with a screw formed from stainless steel, such as surgical grade 316L stainless steel. In some embodiments, the stainless steel screw is coated with a malleable material, such as gold, silver, or polytetraflouroethylene, to improve screw preload. Alternatively, the stainless steel screw may be coated with a harder material, such as diamond like carbon (DLC), amorphous diamond, crystalline diamond, or a combination thereof, which provides a low coefficient of friction providing improved preload properties. | 2009-03-19 |
20090075237 | METHOD FOR MANUFACTURING DIGITALLY-DESIGNED REMOVABLE DENTAL PROSTHESES AND SYSTEM REQUIRED FOR THIS PURPOSE - The system, object of the invention consists of a unit for scanning a mould produced from the sample from a patient's mouth, an image which is sent to digital generation equipment of a removable dental prosthesis, producing a file that is transmitted to metal piece manufacturing equipment by means of sintered powder applying a high-energy ray. The design stages consist of the relief of the mould, the calculation of the insertion axis, the paralleling of the teeth, designing of the elements or components of the prosthesis such as lattice, clamp, stop, major connector, minor connector, bristle, pearls, lingual bars, extrusion of the different elements designed, smoothing of the sharp edges, elimination of the superpositions of the different elements designed and conversion of a closed continuous connected surface to a three-dimensional one. | 2009-03-19 |
20090075238 | Blank arrangement - The invention relates to a blank arrangement, with a blank ( | 2009-03-19 |
20090075239 | COMPOSITIONS INCLUDING POLYMERIZABLE BISPHOSPHONIC ACIDS AND METHODS - The present invention is directed to compositions containing one or more polymerizable bisphosphonic acids and optionally one or more additional polymerizable components. | 2009-03-19 |
20090075240 | Conforming gingiva retraction compression cap and method of retracting tissue around a tooth - A rolled compression cap having a central bore. The rolled compression cap has adjacent layers that slide or telescope to conform to the prepared tooth and to apply more direct mechanical pressure to the interface between the prepared tooth and the gingiva. The gingiva or gum retracts from the tooth forming or widening a gingival sulcus. This improves the preparation of the tooth for taking an impression and fitting a crown or cap. In one embodiment, a rolled compression cap is pre-dosed or soaked with an astringent material or retraction agent. In another embodiment, the central bore of the rolled compression cap is filled with a paste-like or gel material containing an astringent or hemostatic agent. | 2009-03-19 |
20090075241 | Apparatus and method for a directional receiver - A gun system including a gun directional receiver for directionally receiving a response light from a target emitter, wherein the response light includes an identification of the target emitter, and the gun system further including a gun emitter for broadly sending an identification light to a target receiver, wherein the identification light includes the target emitter identification. | 2009-03-19 |
20090075242 | SYSTEM AND METHOD FOR AUTOMATICALLY DEFINING, CREATING, AND MANAGING MEALS - A system and method for method defining, creating, and managing meals according to user preferences regarding a diet plan, preferred foods, preferred meal preparation options, and meal times. An expert system uses information about an individual's diet preferences and related goals, to develop a personalized plan including a complete meal plan and to generate meal suggestion messages for each meal. Meal suggestion messages are transmitted to users' portable devices at their preferred meal times. If a user accepts a meal suggestion, nutritional information regarding the accepted meal is tracked and considered in determining the user's progress toward a goal. If a user rejects a meal suggestion, the expert system generates a meal substitute suggestion or a specific food item substitute suggestion. When the user accepts the substitute suggestion, nutritional information regarding the substituted meal or food item is tracked and considered in determining the user's progress toward a goal. | 2009-03-19 |
20090075243 | Screw-thread fastener directional indicator - A threaded fastener drive simulator includes a threaded rod having first and second ends. A driver head is fixed to the first end of the threaded rod, and a threaded nut is threaded onto the rod in a position between the first and second ends of the threaded ro. A support assembly supports the threaded rod in such a way as to facilitate rotational movement of the driver head and the threaded nut in order to simulate movement of a threaded fastener to be driven. Using this mechanism prior to driving the fastener, the fastener drive simulator is actuated by orienting the fastener drive simulator in the same orientation as the fastener to be driven, and the drive head or nut is rotated to confirm the correct direction to rotate the fastener to affect desired movement of the fastener. | 2009-03-19 |
20090075244 | Models and Methods of Using Same for Testing Medical Devices - Disclosed herein are synthetic anatomical models that are designed to enable simulated use testing by medical device companies, medical device designers, individual inventors, or any other entity interested in the performance of medical devices. These models are unique in possessing a level of complexity that allows them to be substituted for either a live animal, an animal cadaver, or a human cadaver in the testing of these devices. These models are further characterized by a similarity of geometry, individual component physical properties, and component-to-component interfacial properties with the appropriate target tissue and anatomy. | 2009-03-19 |
20090075245 | Method of mounting a game animal and kit therefor - The present invention is a kit and method of mounting a game animal that allows for antlers or horns to be quickly added or interchanged to an otherwise artificial mount. The method generally comprises the following steps: measuring the game animal, taking at least one picture of the game animal, caping the head, cutting the skull, boiling the skull cap, selecting the form, cutting the skull cap to fit the selected form, drilling holes in the skull cap, adding clay to the form, fitting the skull plate to the form, placing screws through the holes in the skull cap, covering the skull cap attached to the form with flaps from the artificial hair, trimming the excess material from the flaps, tucking the flaps around the antler or horn base, and bending the ears of the form to the desired position. The above-described method creates an odorless trophy that is durable, will remain intact for decades, and which has more consistent, lifelike, and more realistic facial features. The method is time efficient, inexpensive, and can be performed for game animals of all species, sizes, and sexes. | 2009-03-19 |
20090075246 | SYSTEM AND METHOD FOR QUANTIFYING STUDENT'S SCIENTIFIC PROBLEM SOLVING EFFICIENCY AND EFFECTIVENESS - In a computer implemented system and method for analyzing problem solving abilities, analytic models are produced to quantify how students construct, modify and retain problem solving strategies as they learn to solve science problems online. Item response theory modeling is used to provide continually refined estimates of problem solving ability as students solve a series of simulations. In parallel, student's strategies are modeled by self-organizing artificial neural network analysis, using the actions that students take during problem solving as the classifying inputs. This results in strategy maps detailing the qualitative and quantitative differences among problem solving approaches. The results are used to provide reports of strategic problem solving competency for a group of students so that teachers can modify teaching strategies to overcome noted deficiencies. | 2009-03-19 |
20090075247 | Interactive educational tool - Graphical user interfaces, systems and methods of implementing an interactive educational tool are disclosed. More specifically, embodiments provide a graphical user interface (GUI) for presenting text and related content associated with a predetermined subject matter. Users may interact with various graphical elements of the GUI for selecting and viewing regions of the subject matter, viewing additional content related to the subject matter, displaying interactive electronic flashcards for studying the subject matter, and entering/reviewing notes taken related to the subject matter. Users may also enter answers to questions and compare the entered answer with the correct answer. Embodiments also enable students to initiate a session with coaches or professors for enabling the coach or professor to observe and evaluate actions of the student related to the predetermined subject matter. | 2009-03-19 |
20090075248 | Particle sensor with wide linear range - This invention provides a novel methods and devices for measurement of particle concentration or changes in particle concentration over a wide linear range. The invention comprises one or more radiation sources and one or more detectors contained in a housing which is interfaced to a medium containing particulate matter. The one or more radiation sources are directed into the medium, scattered or transmitted by the particulate matter, and then some portion of the radiation is detected by the one or more detectors. Methods for confining the measurement to a specific volume within the medium are described. Algorithms are provided for combining the signals generated by multiple source-detector pairs in a manner that results in a wide linear range of response to changes in particle concentration. In one embodiment the sensor provides non-invasive measurements of biomass in a bioreactor. In another embodiment an immersible probe design is described, which may be suited for one-time use. In an addition embodiment, a sensor is provided which is well suited to the rapid sequential measurement of particle concentration in multiple vessels, such as assessment of biomass in series of shake flasks. | 2009-03-19 |
20090075249 | Engineering beta-ketoacyl ACP synthase for novel substrate specificity - Methods of altering substrate specificity of beta-ketoacyl-ACP synthase, and engineered beta-ketoacyl-ACP synthases so produced are provided. DNA sequences and constructs for expression of engineered beta-ketoacyl-ACP synthases, as well as the novel beta-ketoacyl-ACP synthases produced therefrom are also provided. Such DNA sequences may be used for expression of the engineered beta-ketoacyl-ACP synthases in host cells, particularly seed cells of oilseed crop plants, for the modification of fatty acid composition. | 2009-03-19 |
20090075250 | Environmental Sampling and Testing Method - Provided is sampling and testing device for the detection of specific molds, allergens, viruses, bacteria, fungi, and other protein containing substances. Embodiments of the device include a sampling member slideably engaged with a base that contains a lateral flow strip adapted to detect specific analytes of interest. The sampling member defines a solvent reservoir that stores an elution solvent in a fluid-tight manner before the device is used to sample and test environmental surfaces. During slideable withdrawal of the sampling member from the base, the elution solvent stored in the reservoir is automatically released to a wick assembly of the sampling member. The wick assembly includes a wick adapted to receive, distribute, and retain the elution solvent. After a user samples an environmental surface for an analyte of interest with the elution solvent wetted wick, the sampling member is returned to the base where the wick contacts the lateral flow strip contained in the base. The wick transfers at least a portion of analyte and the elution solvent to the lateral flow strip for the calorimetric detection of specific allergens, viruses, bacteria, and other protein containing substances in the sample. The calorimetric results of the test are displayed through a window in the base. | 2009-03-19 |
20090075251 | Method for analysis of cytosine methylation - A method for the analysis of cytosine methylations in DNA is described. Here, the DNA to be investigated is first chemically or enzymatically converted. Then a promoter is introduced into the DNA. After this, the DNA is converted to RNA. The methylation pattern of the DNA can be concluded in different ways by means of an analysis of the RNA. The RNA is preferably fragmented chemically or enzymatically prior to the analysis, whereby the fragmenting results depend on the methylation pattern of the DNA. The method according to the invention is particularly suitable for the diagnosis and prognosis of cancer disorders and other diseases associated with a modification of the methylation pattern. | 2009-03-19 |
20090075252 | Methods for increasing accuracy of nucleic acid sequencing - The invention provides methods for improving the fidelity of a sequencing-by-synthesis reaction by resequencing at least a portion of a nucleic acid template. | 2009-03-19 |
20090075253 | BIOREACTIVE AGENTS - This invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as nucleic acids from biological samples, cells from bodily fluids, and nascent proteins from translation reactions. Agents comprise a detectable moiety bound to a photoreactive moiety. Conjugates comprise agents coupled to substrates by covalent bounds which can be selectively cleaved with the administration of electromagnetic radiation. Targets substances labeled with detectable molecules can be easily identified and separated from a heterologous mixture of substances. Exposure of the conjugate to radiation releases the target in a functional form and completely unaltered. Using photocleavable molecular precursors as the conjugates, label can be incorporated into macromolecules, the nascent macromolecules isolated and the label completely removed. The invention also relates to targets isolated with these conjugates which may be useful as pharmaceutical agents or compositions that can be administered to humans and other mammals. Useful compositions include biological agents such as nucleic acids, proteins, lipids and cytokines. Conjugates can also be used to monitor the pathway and half-life of pharmaceutical composition in vivo and for diagnostic, therapeutic and prophylactic purposes. The invention also relates to kits comprised of agents and conjugates that can be used for the detection of diseases, disorders and nearly any individual substance in a complex background of substances. | 2009-03-19 |
20090075254 | PHYSIOGENOMIC METHOD FOR PREDICTING DIABETES AND METABOLIC SYNDROMES INDUCED BY PSYCHOTROPIC DRUGS - The invention is generally directed to a physiogenomic method for predicting diabetes and metabolic syndromes induced by psychotropic drugs. In one embodiment, the invention relates to the use of genetic variants of marker genes to predict the likelihood that an individual will experience undesirable metabolic side effects as a result of the use of a drug including, but not limited to, psychotropic drugs. The invention also relates to methods predicting the likelihood of diabetes and metabolic syndromes induced by the use of drugs with undesirable metabolic side effects. | 2009-03-19 |
20090075255 | Androgen regulated nucleic acid molecules and encoded proteins - The present invention provides novel androgen regulated nucleic acid molecules. Related polypeptides and diagnostic methods also are provided. | 2009-03-19 |
20090075256 | Nucleic Acid Accessible Hybridization Site Identification Using Mass Spectrometry - The present invention relates to methods and compositions for analyzing nucleic acids, and in particular, methods and compositions for detection and characterization of nucleic acid sequences and sequence changes using mass spectrometry. The present invention also provides methods and compositions for identifying oligonucleotides with desired hybridization properties to nucleic acid targets containing secondary structure using mass spectrometry. | 2009-03-19 |
20090075257 | NOVEL NUCLEIC ACID SEQUENCES AND METHODS OF USE THEREOF FOR DIAGNOSIS - Novel splice variant nucleic acid and amino acid sequences are provided. The novel splice variants and their nucleic acid sequences may be used for diagnosis of variant-detectable diseases particularly cancerous diseases. | 2009-03-19 |
20090075258 | Methods of Normalization in microRNA Detection Assays - This application describes methods of quantifying a target miRNA in a biological sample by measuring the amounts of a target miRNA and at least one reference oncomir in a reaction volume, and normalizing the amount of target miRNA to the amount of one or more reference oncomirs. | 2009-03-19 |
20090075259 | Analyte detection via antibody-associated enzyme assay - The present invention provides methods, kits, and compositions for the detection of an analyte. The invention is particularly suited for the detection and quantification of an analyte in a sample. In the methods of the invention a complex is formed between an analyte specific binding agent and an analyte. The analyte specific agents are coupled to an enzyme possessing an activity that produces a PCR template indicative of the presence of the analyte. Amplification and detection of the PCR template yields a sensitive and quantitative measurement of analyte concentration. | 2009-03-19 |
20090075260 | Methods and Nucleic Acids For Analysis of Cellular Proliferative Disorders - Aspects of the invention provide methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. Particular aspects disclose and provide genomic sequences the methylation patterns of which have substantial utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients. | 2009-03-19 |
20090075261 | SYSTEM AND METHOD FOR AUTHENTICATING TABLETS - A method for authenticating and verifying a pharmaceutical item to be genuine is described. The method for authenticating a tablet comprises applying a particular nucleic acid material associated with a particular sequence of nucleic acid bases to a tablet or capsule. The method also comprises collecting a sample of the tablet and verifying the tablet is genuine by detecting the particular nucleic acid material. | 2009-03-19 |
20090075262 | Gene Methylation In Endometrial Cancer Diagnosis - The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with endometrial cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of endometrial cancer. | 2009-03-19 |
20090075263 | GENE METHYLATION IN OVARIAN CANCER DIAGNOSIS - The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with ovarian cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of ovarian cancer. | 2009-03-19 |
20090075264 | GENE METHYLATION IN LIVER CANCER DIAGNOSIS - The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with liver cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of liver cancer. | 2009-03-19 |
20090075265 | GENE METHYLATION IN THYROID CANCER DIAGNOSIS - The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with thyroid cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of thyroid cancer. | 2009-03-19 |
20090075266 | MULTIPLE ANALYTE DIAGNOSTIC READOUT - The invention provides methods for assessing clinical status through the creation of a diagnostic readout based upon the analysis of multiple biomarkers. According to the invention, an algorithm is provided that allows the use of multiple biomarker thresholds from a patient sample to be used in order to increase the sensitivity and specificity of a diagnostic procedure. | 2009-03-19 |
20090075267 | K-ras and B-raf mutations and anti-EGFr antibody therapy - The present application relates to K-ras mutations, to polynucleotides encoding mutant K-ras polypeptides, and to methods of identifying K-ras mutations. The present application also relates to B-raf mutations, to polynucleotides encoding mutant B-raf polypeptides, to vectors containing those polynucleotides, and to methods of identifying B-raf mutations. The present application also relates to methods of diagnosing cancer; and methods and kits for predicting the usefulness of anti-EGFr specific binding agents in the treatment of tumors. | 2009-03-19 |
20090075268 | Antigenic Targets Of Autoimmune Sensorineural Hearing Loss (AISNHL) And Development Of Tests For Diagnosis And Management Of AISNHL - This invention relates generally to antigens reactive with autoantibodies associated with autoimmune sensorineural hearing loss (AISNHL), and in particular relates to a novel antigen, Inner Ear Supporting Cell Antigen (IESCA) reactive with autoantibodies associated with autoimmune sensorineural hearing loss (AISNHL), and to methods for the detecting therapeutic outcomes in treatment of AISNHL patients, and to methods of detecting genetic lesions in genes encoding for such antigens. | 2009-03-19 |
20090075269 | SYSTEM AND METHOD FOR HIGH RESOLUTION ANALYSIS OF NUCLEIC ACIDS TO DETECT SEQUENCE VARIATIONS - Provided herein are methods for assaying a biological sample for microorganisms having drug resistant and/or drug sensitive phenotypes, wherein the methods are capable of detecting resistant and sensitive phenotypes associated with known and/or unknown mutations. In some aspects, methods are provided for detecting drug resistant | 2009-03-19 |
20090075270 | Products and Methods Relating to the Use of the Endoribonuclease Kid/PemK - The invention relates to a method for engineering a nucleic acid for expression in the presence of Kid/PemK endoribonuclease comprising (i) screening the nucleotide sequence of the nucleic acid for the sequence UUACU or TTACT (ii) mutating said sequence such that there are no longer any occurrences of UUACU or TTACT. The invention also relates to a method of making a ribonucleic acid resistant to Kid/PemK endoribonuclease, said method comprising (a) providing a nucleic acid; (b) screening the nucleic acid for the nucleotide sequence UUACU or TTACT; (c) mutating said sequence such that there are no longer any occurrences of UUACU or TTACT; wherein when the nucleic acid of (a) is a deoxyribonucleic acid, said method further comprises (d) transcribing said deoxyribonucleic acid to produce ribonucleic acid. The invention also relates to vectors and uses of purified or recombinant Kid/PemK endoribonucleases. | 2009-03-19 |
20090075271 | Methods of identifying individuals at risk of perioperative bleeding, renal dysfunction or stroke - The present invention relates, in general, to perioperative bleeding and, in particular, to methods of identifying individuals at risk of perioperative bleeding. | 2009-03-19 |
20090075272 | Method to Identify CD40-Sensitive Cells Using Gene Expression - Gene expression patterns were analyzed in CD40-sensitive and CD40-resistant diffuse large-cell B-lymphoma (DLCBL) cell lines to identify signaling pathways which are involved in CD40-mediated apoptosis. CD40-resistant lines expressed pre-B cell markers including RAG and VPREB, whereas CD40-sensitive cells resembled mature B-cells and expressed higher levels of transcripts encoding several members of the CD40 signaling pathway including LCK and VAV. In addition, CD40 sensitive DLCBL cell lines also displayed constitutive activation of ERK and failed to undergo apoptosis when ERK phosphorylation was inhibited. In contrast, CD40 resistant lines showed no constitutive activation of ERK and no increase in ERK activity in response to CD40 stimulation. The invention includes methods to differentiate between CD40-sensitive and CD-40 resistant cells based on these differences in gene expression. | 2009-03-19 |
20090075273 | Planar Waveguide Detection Chips and Chambers for Performing Multiple PCR Assays - Provided are planar waveguide (“PWG”) detection chips that are used to perform multiplex PCR and kinetic PCR assays with a single fluorescent dye. The PWG detection chips are housed in PWG detection chambers that house at least one PWG chip. The PWG detection chambers may be in a single chamber or a dual chamber configuration. Also provided are methods for analyzing amplification products using the PWG detection chambers of the present invention. | 2009-03-19 |
20090075274 | MULTIPLEXED QUANTITATIVE DETECTION OF PATHOGENS - The invention allows for the quantitative detection of a plurality of pathogens in a single sample. The method includes the amplification of a sample with a plurality of pathogen-specific primer pairs to generate amplicons of distinct sizes from each of the pathogen specific primer pairs. The method further includes the use of a plurality of competitor polynucleotide targets that correspond to each of the pathogen-specific primer pairs. The competitor polynucleotides are added to the reaction mixture at a known concentration to allow for the quantitation of the amount of pathogen in the sample. The method can be used for monitoring pathogen infection in an individual, preferably an immunocompromised individual. | 2009-03-19 |
20090075275 | NUCLEIC ACID PROBE-IMMOBILIZED SUBSTRATE AND METHOD OF DETECTING THE PRESENCE OF TARGET NUCLEIC ACID BY USING THE SAME - The invention provides a nucleic acid probe-immobilized substrate comprising a substrate and a nucleic acid probe containing a nucleotide sequence complementary to a target sequence and immobilized via a spacer onto the substrate, wherein upon hybridization, with the nucleic acid probe, of a target nucleic acid partially containing the target sequence, the spacer satisfies the relationship: | 2009-03-19 |
20090075276 | High throughput mutation screening methods and kits using a universalized approach - differential sequence fill-in (dsf)-enabled sequential adapter ligation and amplification - This disclosure teaches high throughput mutation screening methods allowing simultaneous analysis of multiple genetic regions of interest and sensitive detection of very low frequency mutation(s) by the use of a universalized approach. Methods comprise treating RNA:DNA heteroduplexes of interest with a ribonuclease, sequence extension by an RNA-primed DNA polymerase, ligation with a blocking adapter, and differential sequence fill-in followed by single-strand-specific nuclease digestion to permit full-length sequence extension and subsequent ligation with a tagged reporter adapter solely in mutants filled in with a complementary deoxyribonucleotide triphosphate. By forming tagged mutant-dual adapter hybrids or mutant-triple adapter hybrids, the detection and/or quantification of mutants may be directed to the commonly shared tag(s) or flanking adapter sequences for signal detection/enhancement or sequence amplification in all different mutants regardless of the source or the number of mutations involved, thereby avoiding the tremendous effort of multiple target-specific sequence amplifications. Methods may be performed wholly or partially in solution, on solid phase media, in large scale, adapted for automated or semi-automated analysis, and any combinations thereof. | 2009-03-19 |
20090075277 | Method for detecting ovarian cancer and method for suppressing the same - ABSTRACT An object of the present invention is to provide a method for detecting cancer through identification of genes exhibiting characteristic behavior in the cases of cancer such as ovarian cancer, and a cell growth inhibitor. The present invention provides a method for detecting cancer, which comprises detecting canceration including malignancy of a specimen through detection of at least one alteration of a gene existing in a chromosomal region 2q14. 2, 3p24. 1, 3q26. 2, 3q29, 4q34. 2, 6q23, 9p21. 3, 11q13. 3, 13q22.1, 13q33. 1, 13q33. 3, 15q12, 15q15. 1, 17p12, 17p13. 1, 17p13. 3, 18q21. 1, 18q21. 2, 18q21. 31, 18q21. 32, 18q21. 33, 18q23, 20q13. 13, 20q13. 2, 20q13. 31, 20q13. 33, Xp11. 23, Xp13.1, Xp13. 3, Xp26. 2, Xp26. 3, or Xq28 in the specimen. | 2009-03-19 |
20090075278 | Compositions and methods for the diagnosis and treatment of tumor - The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. | 2009-03-19 |
20090075279 | Compositions and methods for the diagnosis and treatment of tumor - The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. | 2009-03-19 |
20090075280 | EUBACTERIAL tmRNA SEQUENCES AND USES THEREOF - The present invention is directed to eubacterial tmDNA sequences and the corresponding tmRNA sequences. The present invention is further directed to alignments of eubacterial tmDNA sequences and the use of the sequences and sequence alignments for the development of antibacterial drugs. The present invention is also directed to the use of the sequences for the development of diagnostic assays. | 2009-03-19 |
20090075281 | MTBE GENES - The present invention provides methods and compositions for modulating MTBE degradation. The invention also provides methods for identifying compounds that modulate MTBE expression. | 2009-03-19 |
20090075282 | ARTIFICIAL TISSUE CONSTRUCTS COMPRISING ALVEOLAR CELLS AND METHODS FOR USING THE SAME - The present invention comprises artificial tissue constructs that serve as in vitro models of mammalian lung tissue. The artificial tissue constructs of the present invention comprise functionally equivalent in vitro tissue scaffolds that enable immunophysiological function of the lung. The constructs can serve as novel platforms for the study of lung diseases (e.g., interstitial lung diseases, fibrosis, influenza, RSV) as well as smoke- and smoking-related diseases. The artificial tissue constructs of the present invention comprise the two components of alveolar tissue, epithelial and endothelial cell layers. | 2009-03-19 |
20090075283 | Vectors and Methods for Cloning Gene Clusters or Portions Thereof - The present invention relates to a shuttle BAC vector for facilitating the cloning, transfer and heterologous expression of streptomycete secondary metabolite biosynthetic gene clusters. The invention also relates to a plasmid rescue method using this vector for enhancing the process of cloning biosynthetic gene clusters for secondary metabolites from streptomycetes without sophisticated generation and screening of cosmids or BAC libraries. The cloned DNA can then be used for sequencing or heterologous expression of putative secondary metabolic gene clusters. | 2009-03-19 |
20090075284 | METABOLOMIC PROFILING OF PROSTATE CANCER - The present invention relates to cancer markers. In particular, the present invention provides metabolites that are differentially present in prostate cancer. | 2009-03-19 |
20090075285 | PRIMER KIT - The aim of the present invention is to provide a primer kit capable of efficiently amplifying only a required target nucleotide sequence without shortage or excess in the case of amplifying a wide range of target nucleotide sequences. The present invention is directed to a primer kit having a plurality of types of primers for amplifying nucleic acids having a plurality of types of target nucleotide sequences, wherein all of the types of primers are primers capable of amplifying each nucleic acid having a target nucleotide sequence under the same reaction conditions, and a single type of primer or primers corresponding to a single target nucleotide sequence is/are housed in at least one container; and a primer kit having a plurality of types of primers for amplifying nucleic acids having a plurality of types of target nucleotide sequences, wherein all of the types of primers are primers capable of amplifying each nucleic acid having a target nucleotide sequence under the same reaction conditions, and primers corresponding to a single target nucleotide sequence are housed in the same container. | 2009-03-19 |
20090075286 | Detection of Polyketide Synthetase Gene Expression in Karenia Brevis - The present invention concerns an assay for the detection of polyketide synthetase (PKS) mRNA from the red tide dinoflagellate | 2009-03-19 |
20090075287 | METHODS FOR IDENTIFYING NOVEL PESTICIDAL GENE HOMOLOGUES - Methods and compositions for identifying novel pesticidal gene homologues are provided. Specifically, the methods of the invention comprise systematically designing oligonucleotide primers that are specific for a pesticidal gene of interest and performing successive rounds of PCR amplification of nucleic acid material from a microorganism, particularly a | 2009-03-19 |
20090075288 | METHOD FOR DE NOVO DETECTION OF SEQUENCES IN NUCLEIC ACIDS: TARGET SEQUENCING BY FRAGMENTATION - The present invention provides a method for determining nucleic acid sequences of a template nucleic acid that requires no prior knowledge of the nucleic acid sequence present in the template nucleic acid. The method is based on combining information about the mass of a fragment, the mass of any one nucleotide and the combinations thereof, and the sequence specificity of a nucleotide cutter, either enzymatic or chemical cutter, to determine a sequence of a nucleic acid fragment. This method allows for de novo detection of sequences in a target nucleic acid without requiring any prior sequence information. This method is called Partial Sequencing by Fragmentation (PSBF) and it works by fragmenting a target into oligo- or polynucleotides whose masses or lengths are uniquely associated with known sequences. The identities of these sequences are determined solely by the specific fragmentation method used, and are always independent of the target. PSBF can be implemented using electrophoresis, mass spectrometry or any other method that can be used to distinguish the size of the cut nucleic acid sequence fragments. | 2009-03-19 |
20090075289 | Collection Assembly for Obtaining Oral Samples From an Animal - The present invention provides a collection assembly for obtaining a sample from within the mouth of an animal. The collection assembly comprises a collection wand, having a scoop-shaped collecting end, and, optionally, an oral speculum. Also provided are methods of using the collection assembly to obtain an oral sample from the mouth of an animal without causing significant discomfort to the animal. | 2009-03-19 |
20090075290 | IMMUNOCHEMICAL DETERMINATION METHOD AND DETERMINATION REAGENT FOR CYTOCHROME - An immunochemical method for the accurate measurement of the quantity of cytochrome c in a body fluid, in particular, blood, and a kit for the measurement. The quantity of cytochrome c can be measured accurately without being affected by any interfering substrate by reacting an antibody with cytochrome c in a buffer solution in an acidic range. | 2009-03-19 |
20090075291 | PEPTIDE-BASED REGULATION OF GAP JUNCTIONS - The present invention relates to proteins and polypeptides that (i) have the formula A-[W | 2009-03-19 |
20090075292 | METHODS FOR IDENTIFYING MODULATORS OF APOPTOSIS - The invention provides a method of identifying an effective compound that modulates the binding of Humanin to Bax or Bid. The invention also provides a method of identifying an effective compound that modulates an activity of Bax or Bid. In addition, the invention provides a method of identifying a Humanin-like compound that binds to Bax or Bid or modulates an activity of Bax or Bid, or inhibits the apoptotic activity of Bax or Bid. The invention further provides an isolated polypeptide containing a mitochondrial-derived form of Humanin (SEQ ID NO:3) or a functional fragment thereof where the fragment contains the methionine at position 16 of SEQ ID NO:3. | 2009-03-19 |
20090075293 | Methods for predicting embryo viability - The present invention provides methods for predicting the viability of an embryo or for predicting the likelihood of a negative outcome during pregnancy by identifying the presence or absence of or determining the amount of one or more pregnancy associated markers such as molecular isoforms of hCG in a sample. In many instances, the invention is applicable to embryos generated by in vitro fertilization techniques, for instance, to embryos developing in a growth media. The present invention further provides methods for determining the amount of a pregnancy associated markers such as molecular isoforms of hCG (hCG) in a sample. The present invention also provides a diagnostic kit for predicting the viability of an embryo or for predicting the likelihood of a negative outcome during pregnancy by identifying the presence of or determining the amount of one or more pregnancy associated markers such as molecular isoforms of hCG in a sample. | 2009-03-19 |
20090075294 | Eukaryotic mechanosensory transduction channel - The present invention provides, for the first time, nucleic acids encoding a eukaryotic mechanosensory transduction channel (MSC) protein. The proteins encoded by these nucleic acids form channels that can directly detect mechanical stimuli and convert them into electrical signals. These nucleic acids and the proteins they encode can be used as probes for sensory cells in animals, and can be used to diagnose and treat any of a number of human conditions involving inherited, casual, or environmentally-induced loss of mechanosensory transduction activity. | 2009-03-19 |
20090075295 | PORPHYRINIC COMPOUNDS FOR USE IN FLOW CYTOMETRY - The present invention provides a method of detecting (e.g., by flow cytometry) a target compound, cell or particle, wherein the target is labelled with a detectable luminescent compound. The method comprises utilizing as the detectable luminescent compound a compound comprising a porphyrinic macrocycle such as a porphyrin, chlorin, bacteriochlorin, or isobacteriochlorin. In particular embodiments, the detectable luminescent compound comprises a compound of the formula A-A′-Z-B′—B, wherein: A is a targeting group or member of a specific binding pair that specifically binds the detectable luminescent compound to the target compound, cell or particle; A′ is a linker group or covalent bond; B′ is a linker group or covalent bond; B is a water-soluble group; and Z is the porphyrinic macrocycle. | 2009-03-19 |
20090075296 | METHODS AND COMPOSITIONS FOR ASSAYING REGULATORY T CELLS - Methods and compositions for determining whether a T cell is a regulatory T cell and for determining whether a population of cells includes at least one regulatory T cell or a cell with the potential to become a regulatory T cell. The invention includes methods and compositions for detecting TGF-β on the surface of a cell. The invention also provides methods and compositions for evaluating the suppressive activity of a regulatory T cell based on the presence and/or the amount of membrane-bound TGF-β. | 2009-03-19 |
20090075297 | MAMMALIAN GALANIN RECEPTORS - The present invention provides isolated mammalian GalR3 receptors, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods for making the receptors using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptors and are useful for treating medical conditions caused or mediated by galanin. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian GalR3 receptors. | 2009-03-19 |
20090075298 | METHOD OF ANALYZING ENZYME - A method of analyzing an enzyme, comprising (1) bringing a sample suspected of containing an enzyme to be analyzed into contact with an enzyme substrate which is immobilized on an insoluble carrier and can be cleaved by the enzyme, in a liquid, (2) separating the insoluble carrier from the liquid, and (3) analyzing a substrate or a fragment thereof which remains on the insoluble carrier and/or a fragment of the substrate which is released from the insoluble carrier into the liquid; and a kit for analyzing an enzyme, comprising at least an enzyme substrate which is immobilized on an insoluble carrier and can be cleaved by the enzyme, are disclosed. | 2009-03-19 |
20090075299 | Diagnostic Methods - The present invention relates to methods of diagnosing cancerous conditions in a patient, as well as methods of monitoring the progression of a cancerous condition and/or methods of monitoring a treatment protocol of a therapeutic agent or a chemotherapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein. | 2009-03-19 |
20090075300 | METHODS AND COMPOSITIONS FOR THE DETECTION OF CERVICAL DISEASE - Methods and compositions for identifying high-grade cervical disease in a patient sample are provided. The methods of the invention comprise detecting overexpression of at least one biomarker in a body sample, wherein the biomarker is selectively overexpressed in high-grade cervical disease. In particular claims, the body sample is a cervical smear or monolayer of cervical cells. The biomarkers of the invention include genes and proteins that are involved in cell cycle regulation, signal transduction, and DNA replication and transcription. In particular claims, the biomarker is an S-phase gene. In some aspects of the invention, overexpression of a biomarker of interest is detected at the protein level using biomarker-specific antibodies or at the nucleic acid level using nucleic acid hybridization techniques. Kits for practicing the methods of the invention are further provided. | 2009-03-19 |
20090075301 | Diagnostic Marker - A diagnostic marker is composed of particles that have a diameter of from 1 nm to 100 μm, the particles possessing on their surfaces a site that has a high specific bonding ability to a specific antigen residing on the mucosa of digestive cancers and a site that has a low bonding ability to the mucosa of digestive organs, and further incorporating an identification material. | 2009-03-19 |
20090075302 | Compositions and methods for the diagnosis and treatment of tumor - The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. | 2009-03-19 |
20090075303 | Allo and Auto-Reactive T-Cell Epitopes - The present invention relates to a pharmaceutical composition for the prevention of alloimmunisation of a subject or the immunosuppression of a response elicited by alloimmunisation of a subject or an autoimmune haemolytic disease for said composition comprising an immunologically effective epitope of a rhesus protein or an immunologically active analogue or derivative thereof. | 2009-03-19 |
20090075304 | METHODS OF ASSAYING VACCINE POTENCY - The present invention is related to methods of assaying potency of a vaccine composition, wherein the potency is a pre-defined minimum level of potential biological activity for the vaccine composition. The method includes providing a vaccine composition and delivering same to an antigen presenting cell, wherein the vaccine composition is processed into peptides and the peptides are presented by MHC complexes on the cell surface. An agent, such as a T cell receptor mimic, that is reactive against a specific peptide/MHC complex is provided and reacted with the vaccine-treated antigen presenting cell, whereby the agent binds to the cell surface of the vaccine-treated antigen presenting cell if the specific peptide/MHC complex recognized by the agent is present on the cell surface. A density of the specific peptide/MHC complex on the surface of the vaccine-treated antigen presenting cell is measured by agent binding. The potency of the vaccine is then determined based upon the measured density of specific peptide/MHC complex present on the surface of the vaccine-treated antigen presenting cell. | 2009-03-19 |
20090075305 | Diagnostic serum antibody profiling - The invention is directed to a microarray assay procedure that can be used for profiling the antibodies present in serum, plasma or blood. The assay may be used to identify antibodies and antigens that are characteristic of particular diseases or conditions. In addition, the invention includes specific antigens that are associated with prostate cancer, progressive benign prostate hyperplasia (BPH) and ovarian cancer. | 2009-03-19 |
20090075306 | DIAGNOSTIC ASSAY FOR DETECTING AND MONITORING AGE RELATED AND NOISE INDUCED HEARING LOSS - A method of detecting age related and/or noise induced hearing loss in a subject includes detecting in a biological sample from the subject the presence of cochlin antibodies; and correlating the level of detected cochlin antibodies to the presence or absence of age related and/or noise induced hearing loss in the subject. | 2009-03-19 |
20090075307 | METHODS FOR IDENTIFYING PATIENTS WITH AN INCREASED LIKELIHOOD OF HAVING OVARIAN CANCER AND COMPOSITIONS THEREFOR - Screening methods for identifying patients with an increased likelihood of having ovarian cancer are provided. The screening methods involve the detection of expression of a plurality of biomarkers in a body sample, wherein overexpression of the biomarkers is indicative of an increased likelihood of having ovarian cancer. The screening methods may further comprise a two-step analysis. Biomarkers of interest include genes and proteins that are, for example, involved in defects in DNA replication/cell cycle control, cell growth and proliferation, escape from apoptosis, angiogenesis or lymphogenesis, or the mechanisms of cancer cell motility and invasion. In some aspects of the invention, expression of a biomarker is detected at the protein level using a biomarker-specific antibody or at the nucleic acid level using nucleic acid hybridization techniques. Methods for detecting ovarian cancer in patients are further disclosed herein. Kits for practicing the methods of the invention are further provided. | 2009-03-19 |
20090075308 | Method for in vitro phosphorylation of TRAP of Staphylococcus aureus and a method for screening the inhibitor of the TRAP phosphorylation - The present invention relates to a method for in vitro phosphorylation of TRAP derived from | 2009-03-19 |
20090075309 | Bisdeoxycoelenterazine derivatives, methods of use, and BRET2 systems - Embodiments of the present disclosure provide for: compositions, BRET systems, kits, and the like. | 2009-03-19 |
20090075310 | METHOD FOR QUANTITATIVELY DETERMINING LDL CHOLESTEROLS - A method for quantitatively determining LDL cholesterol, including the steps of adding to serum a surfactant selected from among polyoxyethylenealkylene phenyl ethers and polyoxyethylenealkylene tribenzylphenyl ethers and a cholesterol-assaying enzyme reagent so as to preferentially react cholesterols in high density- and very low density-cholesterols among lipoproteins, and subsequently determining the amount of cholesterol that reacts thereafter. This method can eliminate the necessity for pretreatments such as centrifugation and electrophoresis, enables the quantitative determination to be conducted in an efficient, simple manner, and can be applied to various automatic analyzers. | 2009-03-19 |
20090075311 | ASSESSING COLORECTAL CANCER BY MEASURING HEMOGLOBIN AND M2-PK IN A STOOL SAMPLE - The present invention relates to a method aiding in the assessment of colorectal cancer. The method especially is used in assessing the absence or presence of colorectal cancer in vitro. The method is, for example, practiced by analyzing biochemical markers, comprising measuring in a stool sample the concentration of hemoglobin and M2-PK and correlating the concentrations determined to the absence or presence of colorectal cancer. To further improve the assessment of colorectal cancer in a method of this invention the level of one or more additional marker may be determined together with hemoglobin and M2-PK in a stool sample and be correlated to the absence or presence of colorectal cancer. The invention also relates to the use of a marker panel comprising hemoglobin and M2-PK in the early diagnosis of colorectal cancer, and it teaches a kit for performing the method of the invention. | 2009-03-19 |