11th week of 2014 patent applcation highlights part 42 |
Patent application number | Title | Published |
20140072931 | ORAL CARE DEVICE - An oral care device suitable for use in providing a beneficial effect to an oral cavity of a mammal, which device includes means for providing reciprocation of a liquid effective for providing the beneficial effect of the oral cavity when the liquid is contacted with a plurality of surfaces thereof under conditions effective to provide the beneficial effect. | 2014-03-13 |
20140072932 | INTRA-ORAL LIGHT THERAPY APPARATUSES AND METHODS FOR THEIR USE - In some embodiments, an apparatus comprises a housing, an emitter, and an electronic circuit. The housing is configured to fit within a patient's mouth. The emitter is at least partially encased within the housing. The emitter is configured to emit an effective amount of light to the alveolar soft tissue when the housing is disposed within the mouth. The electronic circuit is operatively coupled to the emitter. The electronic circuit is configured to control the emitter when the housing is disposed within the mouth and the apparatus is in use during orthodontic treatment. The apparatus and its use for regulating tooth movement or maintaining or improving oral tissue health are disclosed herein. | 2014-03-13 |
20140072933 | ARTIFICIAL TEETH - The invention enables artificial molar teeth to be arranged at appropriate positions according to the oral cavity environment of each patient without requiring advanced techniques or experience. The artificial molar teeth have maxillary molar teeth and mandibular molar teeth arranged so as to form a pair on denture bases to be mounted on upper and lower jaws in an oral cavity, in which one cusp out of the cusps of the maxillary molar teeth and the mandibular molar teeth is engaged with a fossa of the antagonist, and at least one of the other cusps is engaged with a groove of the antagonist. | 2014-03-13 |
20140072934 | PERIODONTAL DISEASE DEVICES AND METHODS - Devices and methods are provided for treating a periodontal defect adjacent to a tooth, the devices and methods use a barrier configured to reduce an amount of material from entering into the periodontal defect, the barrier having a first region configured to retain a portion of the barrier against at least a portion of the tooth and a second region configured to extend over at least a portion of the periodontal defect adjacent to the tooth so as to reduce the amount of material from entering into the periodontal defect. In some embodiments, the devices and methods provided can be removed from the healed periodontal defect without the need to cut into healed soft tissue. | 2014-03-13 |
20140072935 | Method of Regulating Caloric Intake - A method, including: selecting at least one favored food item; determining a target caloric intake for a period, determining an amount of calories desired for a caloric up-adjustment, wherein the up-adjustment reduces any caloric intake shortfall from the target caloric intake for the period; and making at least one food recommendation including a number of servings of one favored food item or any combination of more than one favored food item. A total caloric impact of the recommendation includes a caloric content of the recommended food plus an allotment for an expected transient increase in caloric intake necessary to reach a same level of satiety during a subsequent transient increase in appetite. The food recommendation is selected to be a food recommendation including a total caloric impact that best matches the desired up-adjustment calories. | 2014-03-13 |
20140072936 | Method of Tracking Consumption and Associated Effects - A method, including: tracking a quantity of an item consumed and when the consumption occurs; tracking if an effect was felt and a magnitude of the effect felt; selecting an item of interest; displaying in graphical form the quantity of the item of interest consumed and when the consumption of the item of interest occurred; displaying in graphical form when the effect was felt and the magnitude of the effect felt; and determining if a relationship can be drawn between the display of the quantity of the item of interest consumed and when the consumption of the item of interest occurred and the display of the magnitude of the effect felt and when the effect was felt. | 2014-03-13 |
20140072937 | SYSTEM AND METHOD OF TESTING CANDIDATES' SKILL OF USE OF CUTTING TOOLS AND COMPILING AND MANAGING DATA RELATED TO CANDIDATES' TEST RESULTS AND PROVIDING DATA TO POTENTIAL EMPLOYERS - A system for remote communication of information relating to cutting operations includes a template that is configured for cutting by a person. The template includes an indication that indicates a predetermined path for cutting of the template. The system also includes a first computerized device having an input device configured to input cutting information. The cutting information relates to cutting of the template along the predetermined path. The system also includes a second computerized device that is remote from the first computerized device. The second computerized device is configured to receive the cutting information. Moreover, the system includes a communications device configured to provide communication between the first computerized device and the second computerized device to allow the cutting information to be sent from the first computerized device to the second computerized device. | 2014-03-13 |
20140072938 | METHOD AND SYSTEM FOR TRAINING SPORTS OFFICIALS - A method and system is provided for training sports referees, and particularly to help referees understand the application of rules to game plays or situations between competitors. The method and system includes live action plays recorded from one or more referee perspectives on the field or court. The plays are downloaded into a database so that a trainee can select specific plays and apply specific rules to the selected plays so as to understand application of the rule to a game situation. Multiple perspectives of the same play can be recorded and viewed simultaneously in real time or frame by frame. | 2014-03-13 |
20140072939 | SYSTEMS AND METHODS FOR IDENTIFYING PATIENT PREFERENCES WITH RESPECT TO MEDICAL TREATMENT ATTRIBUTES - Embodiments facilitate determining patient preferences with respect to treatment attributes. A set of treatment options, comprising attributes, for a medical condition may be accessed. A first subset of treatment options may be selected and displayed to a patient. An indication may be received from the patient of a most preferred treatment option and/or a least preferred treatment option. Using the indications received from the patient regarding the first subset of treatment options, another subset of treatment options may be adaptively selected. An indication from the patient of a most preferred treatment option and/or a least preferred treatment option of the adaptively selected subset of treatment options may be received. Based at least in part on the indications received from the patient, a utility function may be generated. The utility function may be used to generate, optionally in substantially real-time, scoring and/or ranking information with respect to the plurality of attributes. | 2014-03-13 |
20140072940 | CPR TRAINING DEVICE AND METHOD OF USE - A CPR training device for simulating continuous chest compressions has a weight measuring scale with a visual indicator of applied force or weight. The visual indicator includes a graduated measuring scale measuring 0 pounds to at least 140 pounds; and a pointer or needle movable in response to an applied force or weight. The CPR training device visually shows the applied force of each compression. The CPR training device has a top surface having a label. The label is adhered to the top surface and has a target zone identifying the location CPR compressions are to be applied. The target zone is preferably graphically depicted in the shape of a heart. | 2014-03-13 |
20140072941 | SIMULATED TISSUE, BODY LUMENS AND BODY WALL AND METHODS OF MAKING SAME - An artificial body wall is disclosed herein. The artificial body wall may include a first layer and a second layer. The first layer is substantially formed of a silicone rubber and includes at least one of an artificial epidermis-dermis layer or an artificial subcutaneous layer. The second layer extends along and below the first layer and is substantially formed of a silicone rubber. The second layer includes at least one of an artificial fascia layer or an artificial muscle layer. At least one of the first layer or second layer may be vascularized. | 2014-03-13 |
20140072942 | Modular Frames For Arrangement And Orientation Of Geometric Solids - Modular frames for instructional use that provide secure mounts for geometric solids are presented. Some contemplated modular frames can be assembled into three dimensional modular devices and are particularly suitable for instructional purposes. Modular devices comprising two or more frames could be coupled via a clip in two or more different configurations. Containers including conductive material and configured to provide a Faraday cage around their contents are also provided. | 2014-03-13 |
20140072943 | JOINTED LEG SYSTEM FOR TAXIDERMY - A leg for attachment to a main body of a taxidermy mannequin includes first, second, and third portions, each having first and second ends. The first end of the first portion includes a connector for coupling to the main body. The first end of the second portion is connected to the second end of the first portion to form a first joint. At least one of the first or second portions has a first cut-away section proximate the first joint with a reduced thickness. The first end of the third portion is connected to the second end of the second portion to form a second joint. At least one of the second or third portions has a second cut-away section proximate the second joint with a reduced thickness. | 2014-03-13 |
20140072944 | Systems, Methods, And Computer Program Products For Providing A Learning Aid Using Pictorial Mnemonics - A system, method and computer program product for providing a learning aid using pictorial mnemonics. The method can include receiving a first input including a selection of a content topic. The method further includes displaying a first pictorial mnemonic associated with the selected topic, wherein the first pictorial mnemonic comprises one or more sub-images, and a list of one or more attributes, wherein each attribute is associated with a corresponding sub-image. | 2014-03-13 |
20140072945 | Method and a system to deliver a live and instant interactive school experience over a plurality of learning sites at different locations, such locations being broadcast simultaneously to a plurality of cohort or individual learners at different locations throughout a network. - A system for delivering distance learning enables a plurality of teaching sites to be streamed to multiple locations via a network with instant, real time information conveyance and instant interaction between at least one teacher at least one of said teaching sites and at least one learner at least one learning site via video images, audio signals, whiteboard functions, and other text chat messaging and other digital signal modes. | 2014-03-13 |
20140072946 | Identity Management for Computer Based Testing System - A method and system for identity management and authentication of examination candidates by, for example, capturing biometric data and identification information from an examination candidate and storing the data and information in a database. The method and system includes, for example, capturing biometric data from an individual at a later time for comparison with data stored in the database, and which allows authentication of the individual after determining that the biometric data matches the previously stored data and the individual matches the previously stored information. | 2014-03-13 |
20140072947 | GENERATING SECONDARY QUESTIONS IN AN INTROSPECTIVE QUESTION ANSWERING SYSTEM - A method of generating secondary questions in a question-answer system. Missing information is identified from a corpus of data using a computerized device. The missing information comprises any information that improves confidence scores for candidate answers to a question. The computerized device automatically generates a plurality of hypotheses concerning the missing information. The computerized device automatically generates at least one secondary question based on each of the plurality of hypotheses. The hypotheses are ranked based on relative utility to determine an order in which the computerized device outputs the at least one secondary question to external sources to obtain responses. | 2014-03-13 |
20140072948 | GENERATING SECONDARY QUESTIONS IN AN INTROSPECTIVE QUESTION ANSWERING SYSTEM - A method of generating secondary questions in a question-answer system. Missing information is identified from a corpus of data using a computerized device. The missing information comprises any information that improves confidence scores for candidate answers to a question. The computerized device automatically generates a plurality of hypotheses concerning the missing information. The computerized device automatically generates at least one secondary question based on each of the plurality of hypotheses. The hypotheses are ranked based on relative utility to determine an order in which the computerized device outputs the at least one secondary question to external sources to obtain responses. | 2014-03-13 |
20140072949 | METHOD FOR CHANGING MODES IN AN ELECTRONIC DEVICE - The present disclosure provides a method for activating an electronic device. The electronic device includes a user interface and a task application in communication with the user interface, wherein the task application compares a user action received through the user interface to the primary task answer and activates the user interface inactive mode if the user action matches that of the primary task answer. In addition, the task application may be configured to apply the user action in generating a subsequent primary task including selecting a degree of difficulty for the subsequent primary task intended to enable a user to activate the electronic device within a target range of time. | 2014-03-13 |
20140072950 | POWER FREQUENCY PARAMETER SIMULATION SYSTEM FOR A POWER TRANSMISSION LINE AND CONTROL METHOD THEREOF - A power frequency parameter simulation system for a power transmission line and a control method thereof, the system comprises a simulation main circuit (1), an interference power supply (2) and a procedure controller (3). In the system, a power frequency parameter of a 10 to 100 kilometers of 500 kV power transmission line is simulated in a parameter integration manner; and the control method comprises the following steps of: a step to detect the automatically zeroing during starting up, a step to control the reduction of the length of a simulation line and a step to control a simulation interference voltage. A long-distance power transmission line is realized to be moved into a room and be tested by means of the power frequency parameter test system, so the various inconveniences of on-site measurement are avoided. The system realizes intelligent control over the simulation power line according to acquisition and analysis of the procedure controller to a signal, secure and reliable test and experiment performed on the power frequency parameter of the line in a laboratory can be realized, reliable training equipment is provided for learners, the anti-interference capability of a tester can be checked, and the whole system is applicable to line parameter testers produced by most of the conventional factories in China. | 2014-03-13 |
20140072951 | FIBER SCAFFOLDS FOR USE IN ESOPHAGEAL PROSTHESES - The development and construction of implantable artificial organs, and a process for manufacturing three-dimensional polymer microscale and nanoscale structures for use as scaffolds in the growth of biological structures such as hollow organs, luminal structures, or other structures within the body are disclosed. | 2014-03-13 |
20140072952 | Microstructure for Particle and Cell Separation, Identification, Sorting, and Manipulation - The invention relates to microscale cell separating apparatus which are able to separate cells on the basis of size of the cells, interaction of the cells with surfaces of the apparatus, or both. The apparatus comprises a stepped or sloped separation element ( | 2014-03-13 |
20140072953 | Microstructure for Particle and Cell SEparation, Identification, Sorting, and Manipulation - The invention relates to microscale cell separating apparatus which are able to separate cells on the basis of size of the cells, interaction of the cells with surfaces of the apparatus, or both. The apparatus comprises a stepped or sloped separation element ( | 2014-03-13 |
20140072954 | MONONUCLEAR CELL PREPARATION MATERIAL AND MONONUCLEAR CELL PREPARATION METHOD USING SAME - The present invention aims to provide a mononuclear cell preparation material capable of improving the mononuclear cell recovery while reducing granulocyte contamination, and a mononuclear cell preparation method which improves the mononuclear cell recovery. Provided is a mononuclear cell preparation material for removing granulocytes from blood to prepare mononuclear cells, which includes a nonwoven fabric made of a polyamide resin. Also provided is a method for preparing mononuclear cells using a device with the mononuclear cell preparation material packed in a container, the method including the steps of: (A) passing blood through the mononuclear cell preparation device from an inlet side to an outlet side of the device, thereby capturing granulocytes in the device; and (B) passing a washing solution through the mononuclear cell preparation device from the inlet side to the outlet side of the device, thereby recovering mononuclear cells remaining in the device. | 2014-03-13 |
20140072955 | VISUAL-SERVOING OPTICAL MICROSCOPY - The present invention provides methods and devices for the knowledge-based discovery and optimization of differences between cell types. In particular, the present invention provides visual servoing optical microscopy, as well as analysis methods. The present invention provides means for the close monitoring of hundreds of individual, living cells over time; quantification of dynamic physiological responses in multiple channels; real-time digital image segmentation and analysis; intelligent, repetitive computer-applied cell stress and cell stimulation; and the ability to return to the same field of cells for long-term studies and observation. The present invention further provides means to optimize culture conditions for specific subpopulations of cells. | 2014-03-13 |
20140072956 | COMPOSITION, DEVICE AND ASSOCIATED METHOD - A composition includes a first probe capable of binding to a first analyte and a first initiator bonded to the first probe. The composition further includes a second probe capable of binding to a second analyte and a second initiator bonded to the second probe. At least one of the first initiator or the second initiator is capable of initiating a controlled polymerization reaction. An associated kit, device, and method are provided. | 2014-03-13 |
20140072957 | GENETIC POLYMORPHISMS ASSOCIATED WITH LIVER FIBROSIS, METHODS OF DETECTION AND USES THEREOF - The present invention is based on the discovery of genetic polymorphisms that are associated with liver fibrosis and related pathologies. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection. | 2014-03-13 |
20140072958 | NOVEL INFLUENZA HEMAGGLUTININ PROTEIN-BASED VACCINES - Novel vaccines are provided that elicit broadly neutralizing anti-influenza antibodies. Some vaccines comprise nanoparticles that display hemagglutinin trimers from influenza virus on their surface. The nanoparticles comprise fusion proteins comprising a monomeric subunit of ferritin joined to at least a portion of an influenza hemagglutinin protein. Some portions comprise the ectodomain while some portions are limited to the stem region. The fusion proteins self-assemble to form the hemagglutinin-displaying nanoparticles. Some vaccines comprise only the stem region of an influenza hemagglutinin protein joined to a trimerization domain. Such vaccines can be used to vaccinate an individual against infection by heterologous influenza viruses and influenza virus that are antigenically divergent from the virus from which the nanoparticle hemagglutinin protein was obtained. Also provided are fusion proteins and nucleic acid molecules encoding such proteins. Finally, also provided are assays using nanoparticles of the invention to detect anti-influenza antibodies. | 2014-03-13 |
20140072959 | RAPID TESTS FOR INSURANCE UNDERWRITING - The present invention relates to rapid test devices, kits and systems comprising the rapid test devices for assessing at least two analytes in a sample derived from a life or health insurance applicant, said at least two analytes being selected from the group consisting of a human immunodeficiency virus (HIV) antigen (e.g., a HIV polypeptide), a HIV polynucleotide, an anti-HIV antibody, a hepatitis C virus (HCV) antigen (e.g., a HCV polypeptide), a HCV polynucleotide, an anti-HCV antibody, a liver enzyme alanine transaminase (ALT), a liver enzyme aspartate transaminase (AST), nt-probnp (or NT-proBNP), probnp (or proBNP), cotinine, nicotine, cocaine, a metabolite of cocaine (e.g., benzoylecgonine), prostate-specific antigen (PSA), apolipoprotein A-1 (ApoA1), apolipoprotein B (ApoB), Hemoglobin A1c and high-sensitivity C-reactive protein (hsCRP). The present invention also relates to methods for using the rapid test devices, kits and systems as part of the assessment of the life or health insurance applications. | 2014-03-13 |
20140072960 | SELF DIAGNOSTIC TEST - A test unit collects and analyzes biological specimens on-site. It has one or more openings that allow reagent capsules to be inserted and guided into a testing chamber. Reagent capsules are preloaded with chemicals for screening and are configured as blister packs. A button mechanism allows projection(s) to open the blister packs to allow chemicals within the capsules to mix inside the testing chamber. A medical swab is affixed to a pop top dispenser cap and can be pressed to allow the swab to be inserted into the mixed chemicals. A visible test strip mount attached to the testing chamber has a lever to manipulate a test strip in and out of the testing chamber. This test strip may be slid through a uni-directional seal on a capsule and into a chemical for testing. The test strip will test for the presence of an infectious disease. | 2014-03-13 |
20140072961 | Method of Genome Surgery with Paired, Permeant Endonuclease Excision - The use of P2E2 constructs in genome surgery includes a cell penetration component, a DNA binding component and a restriction endonuclease. The method for performing genome surgery includes:
| 2014-03-13 |
20140072962 | SYSTEMS, DEVICES, AND METHODS FOR IDENTIFYING A DISEASE STATE IN A BIOLOGICAL HOST USING INTERNAL CONTROLS - Contemplated methods and devices comprise detecting the presence of a pathogen in a biological host. In certain implementations, a sample is provided from a biological host. A biosensor is provided, the biosensor having a first probe configured to detect a control marker in the sample, the control marker being an endogenous element of the biological host. The biosensor has a second probe configured to detect the presence of a target marker in the sample, the target marker being from a pathogen in the biological host. The sample is applied to the biosensor, and the presence or absence of the control marker in the sample is identified using the first probe. The presence or absence of the target marker in the sample is identified using the second probe. | 2014-03-13 |
20140072963 | ELECTROCHEMILUMINESCENCE IMMUNOASSAY METHOD - Disclosed is an electrochemiluminescence immunoassay method, using a full reaction of a Ru(bpy) marked protein-primary antibody, a biotinylated protein-secondary antibody to be tested, and a sample to be tested; addition of a Streptavidin-coated magnetic particle to form a complex comprising an antigen, an antibody, and a magnetic particle; adsorption to an electrode surface by the magnetic particle; addition of a dibutyl ethanolamine solution; testing by means of an electrochemical method. Also disclosed is a corresponding electrochemiluminescence immunoassay detection kit. | 2014-03-13 |
20140072964 | Cooperating Capillary and Cap for Use in a High-Pressure Freezer - The invention relates to an assembly of a cooperating capillary and cap for containing an aqueous solution in an inner volume of the capillary. The assembly is used in a high pressure freezer in which the aqueous solution is frozen at a high pressure to form an amorphous frozen sample at a cryogenic temperature. The cap forms a closure at one end of the capillary, and the part of the cap that is in contact with the inner volume of the capillary has an indent; as a result of which the cap, after freezing the aqueous solution, can be removed from the capillary and a free standing pillar of frozen aqueous material extends from the capillary. | 2014-03-13 |
20140072965 | 1, 2-Dichloropropane-to-Propene Reductive Dehalogenase Genes - The invention is directed to novel reductive dehalogenase genes encoding for reductive dehalogenases, which are capable of dehalogenating halogenated organic compounds and may be useful for environmental assessment and monitoring, and in the bioremediation of pollutants. In particular, the invention provides isolated polynucleotides of novel reductive dehalogenase genes dcpA and dcpB and fragments thereof as well as isolated polypeptides encoding the DcpA and DcpB proteins or fragments thereof. The invention is also directed to methods of identifying and/or quantifying dechlorinating bacterial organisms or polynucleotides encoding a reductive dehalogenase, such as the dcpA or dcpB polynucleotides or fragments thereof, in a sample. | 2014-03-13 |
20140072966 | GENETIC BIOMARKERS FOR GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY - The genetic biomarkers for glucose-6-phosphate dehydrogenase (G6PD) deficiency are five haplotypes representing mutations of the G6PD gene on the X chromosome. Each of these haplotypes codes for more than one non-conservative amino acid change. The present inventors have discovered that when mutations of the G6PD gene result in at least two non-conservative amino acid changes in combination, expression of the G6PD enzyme or the stability of the G6PD enzyme is severely decreased, presenting a substantial risk of disease resulting from the deficiency, even in female patients who would normally be considered asymptomatic carriers of the genetic mutation(s). | 2014-03-13 |
20140072967 | METHOD OF DETECTING SINGLE NUCLEOTIDE POLYMORPHISMS - Use of low-temperature nucleic acid amplification and binary probes to detect sequences and single nucleotide polymorphisms. | 2014-03-13 |
20140072968 | Novel Genes Encoding Proteins Having Prognostic, Diagnostic, Preventive, Therapeutic, and Other Uses - The invention provides isolated TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided. | 2014-03-13 |
20140072969 | Differential Diagnosis Of Cancer And Other Conditions Based On Expression Of p63 - This invention relates to methods of distinguishing among various types of differentiated and undifferentiated epithelial carcinomas, and non-epithelial carcinomas, by detecting the presence of p63 nucleic acid or protein expression. The invention also provides methods for detecting p63 nucleic acids and proteins, as well as methods for diagnosing and treating certain tumors based on whether the tumors express p63. | 2014-03-13 |
20140072970 | LAFORA'S DISEASE GENE - A novel gene (EPM2B) that is mutated in humans and dogs with Lafora's disease is described. | 2014-03-13 |
20140072971 | PRAME DETECTION ASSAYS - Provided herein are molecular assays, including oligonucleotides and other reagents, for the detection and analysis of PRAME (Preferentially Expressed Antigen in Melanoma). The assays find use, for example, as diagnostic and prognostic applications, including use in assessing therapeutic courses of action. | 2014-03-13 |
20140072972 | TMPRSS2 FOR THE DIAGNOSIS OF PROSTATE DISEASE - Described herein are methods, compositions and kits directed to the detection the 5′ portion of TMPRSS2 mRNA for the detection and diagnosis of prostate disease including prostate cancer and benign prostatic hyperplasia. | 2014-03-13 |
20140072973 | LMNA GENE AND ITS INVOLVEMENT IN HUTCHINSON-GILFORD PROGERIA SYNDROME (HGPS) AND ARTERIOSCLEROSIS - Disclosed herein are point mutations in the LMNA gene that cause HGPS. These mutations activate a cryptic splice site within the LMNA gene, which leads to deletion of part of exon 11 and generation of a mutant Lamin A protein product that is 50 amino acids shorter than the normal protein. In addition to the novel Lamin A variant protein and nucleic acids encoding this variant, methods of using these molecules in detecting biological conditions associated with a LMNA mutation in a subject (e.g., HGPS, arteriosclerosis, and other age-related diseases), methods of treating such conditions, methods of selecting treatments, methods of screening for compounds that influence Lamin A activity, and methods of influencing the expression of LMNA or LMNA variants are also described. Oligonucleotides and other compounds for use in examples of the described methods are also provided, as are protein-specific binding agents, such as antibodies, that bind specifically to at least one epitope of a Lamin A variant protein preferentially compared to wildtype Lamin A, and methods of using such antibodies in diagnosis, treatment, and screening. Also provided are kits for carrying out the methods described herein. | 2014-03-13 |
20140072974 | METHODS FOR QUANTITATIVE AMPLIFICATION AND DETECTION OVER A WIDE DYNAMIC RANGE - Disclosed are compositions and methods for making differentiable amplicon species at unequal ratios using a single amplification system in a single vessel. The number of differentiable amplicons and their ratios to one another are chosen to span the required linear dynamic range for the amplification reaction and to accommodate limitations of the measuring system used to determine the amount of amplicon generated. Unequal amounts of distinguishable amplicon species are generated by providing unequal amounts of one or more amplification reaction components (e.g., distinguishable amplification oligomers, natural and unnatural NTP in an NTP mix, or the like). The amount of target nucleic acid present in a test sample is determined using the linear detection range generated from detection of one or more amplicon species having an amount within the dynamic range of detection. | 2014-03-13 |
20140072975 | COMPOSITIONS AND METHODS FOR DETERMINING GENETIC POLYMORPHISMS IN THE TMEM216 GENE - In alternative embodiments, the invention provides nucleic acid sequences that are genetic polymorphic variations of the human TMEM216 gene, and TMEM216 polypeptide encoded by these variant alleles. In alternative embodiments, the invention provides methods of determining or predicting a predisposition to, or the presence of, a ciliopathy (or any genetic disorder of a cellular cilia or cilia anchoring structure, basal body or ciliary function) in an individual, such as a Joubert Syndrome (JS), a Joubert Syndrome Related Disorder (JSRD) or a Meckel Syndrome (MKS). In alternative embodiments, the invention provides compositions and methods for the identification of genetic polymorphic variations in the human TMEM216 gene, and methods of using the identified genetic polymorphisms and the proteins they encode, e.g., to screen for compounds that can modulate the human TMEM216 gene product, and possibly treat JS, JSRD or MKS. | 2014-03-13 |
20140072976 | URINE STABILIZATION SYSTEM - The present disclosure relates, according to some embodiments, to a method of stabilizing a molecule (e.g., a biomolecule) in a bodily fluid comprising: (1) providing a stabilizing solution comprising: (a) an amount of a divalent metal chelator selected from the group consisting of ethylenediaminetetraacetic acid (EDTA), (ethylenebis(oxyethylenenitrilo))tetraacetic acid (EGTA), and 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid (BAPTA) and salts thereof in the range of from about 0.001 M to about 2 M; and (b) an amount of at least one chelator enhancing component selected from the group consisting of lithium chloride, guanidinium chloride, guanidinium thiocyanate, sodium salicylate, sodium perchlorate, and sodium thiocyanate in the range of from about 0.1 M to about 10 M; and (2) adding the stabilizing solution to the bodily fluid, thus stabilizing the molecule. A biomolecule may be selected from a nitrite, a carbohydrate, a ketone, a globin, a bilirubin, a lipid, and combinations thereof in some embodiments. | 2014-03-13 |
20140072977 | Systems and Methods for Determining a C-Peptide Receptor, C-Peptide Receptor, and Methods of Using Same - Systems and methods for the determination of a peptide receptor. Specifically to determine a receptor for any peptide provided that the receptor is a G protein coupled receptor (GPCR). | 2014-03-13 |
20140072978 | Nicking and Extension Amplification Reaction for the Exponential Amplification of Nucleic Acids - The invention is in general directed to the rapid exponential amplification of short DNA or RNA sequences at a constant temperature. | 2014-03-13 |
20140072979 | ISOLATING CELLS EXPRESSING SECRETED PROTEINS - A method of detecting and isolating cells that produce a secreted protein of interest (POI) that has an immunoglobulin CH3 domain and/or substituted CH3 domain, comprising: a) constructing a cell line transiently or stably expressing a cell surface capture molecule, which binds the POI, by transfecting the cell line with a nucleic acid that encodes such cell surface capture molecule; b) transfecting said cell simultaneously or subsequently with a second nucleic acid that encodes a POI wherein such POI is secreted; c) detecting the surface-displayed POI by contacting the cells with a detection molecule, which binds the POI; and d) isolating cells based on the detection molecule. | 2014-03-13 |
20140072980 | ISOLATING CELLS EXPRESSING SECRETED PROTEINS - A method of detecting and isolating cells that produce a secreted protein of interest (POI) that has an immunoglobulin CH3 domain and/or substituted CH3 domain, comprising: a) constructing a cell line transiently or stably expressing a cell surface capture molecule, which binds the POI, by transfecting the cell line with a nucleic acid that encodes such cell surface capture molecule; b) transfecting said cell simultaneously or subsequently with a second nucleic acid that encodes a POI wherein such POI is secreted; c) detecting the surface-displayed POI by contacting the cells with a detection molecule, which binds the POI; and d) isolating cells based on the detection molecule. | 2014-03-13 |
20140072981 | CYSTEINE HYDRAZIDE NICOTINAMIDE FOR GLYCOMICS AND GLYCOPROTEOMICS USES - A cysteine hydrazide nicotinamide (Cyhn) reagent designed for the enrichment of bacterial glycoproteins is provided. Methods for purification of free oligosaccharides and their analysis are also provided. | 2014-03-13 |
20140072982 | SPECIFIC SALIVARY BIOMARKERS FOR RISK DETECTION, EARLY DIAGNOSIS, PROGNOSIS AND MONITORING OF ALZHEIMER'S AND PARKINSON'S DISEASES - Methods by which specific biomarkers in saliva are used for risk detection, early diagnosis, prognosis and monitoring of Alzheimer's and Parkinson's diseases. | 2014-03-13 |
20140072983 | Dual function in vitro target binding assay for the detection of neutralizing antibodies against target antibodies - An in vitro assay method is disclosed. This non-cell-based dual function target binding assay is useful for detecting both an IgG target antibody, such as a biologic drug, in a biological sample (e.g., a serum sample) and the presence of neutralizing antibodies (NAb) against the IgG target antibody. | 2014-03-13 |
20140072984 | SOLUBLE GP130 MUTEINS WITH IMPROVED BINDING ACTIVITY - Described are soluble gp130 polypeptide monomers and dimers, wherein, in a preferred embodiment, at least one of the three amino acid residues Thr | 2014-03-13 |
20140072985 | Bioassay Method for Antibody Against Thyroid-Stimulating Hormone Receptor, Measurement Kit for the Antibody, and Novel Genetically Modified Cell for Use in the Bioassay Method or the Measurement Kit - The present invention provides a method and a kit for assaying a TSH receptor antibody, which are easy to manipulate and are safe. Specifically, the present invention provides a composition comprising a genetically modified cell forced to co-express a TSH receptor, a cyclic nucleotide responsive calcium channel, and a luminescent protein aequorin. Use of the composition enables the assay of a TSH receptor antibody contained in a sample. | 2014-03-13 |
20140072986 | AMYLOID PROTEIN OLIGOMER-BINDING APTAMER - An aptamer having a G-quartet structure and being at least one selected from the group consisting of the following polynucleotides, the aptamer having a binding ability to an amyloid protein oligomer: (1) a polynucleotide comprising a base sequence represented by any one of SEQ ID NO:1 to SEQ ID NO:18; (2) a polynucleotide comprising a base sequence that includes at least four sets of at least two consecutive guanosine nucleotides and in which one or several bases has been deleted, substituted, or added in a base sequence represented by any one of SEQ ID NO:18; and (3) a polynucleotide that is a multimer including the polynucleotide of (1) or (2) as a structural unit. | 2014-03-13 |
20140072987 | METHODS OF DETECING BLADDER CANCER - The disclosure relates to methods of detecting bladder cancer including assaying a patient sample for the levels of certain combinations of biomarkers. The disclosure also relates to methods for determining the efficacy of a drug for the treatment of bladder cancer. | 2014-03-13 |
20140072988 | DETERMINATION OF VITAMIN D METABOLITES IN DRIED BLOOD - Method and test kit for quantitative determination of Vitamin D metabolites in blood, wherein a predetermined amount of blood is pre-analytically immobilised on a solid sorption material. Thereby, hemolysis of the blood has no effect on the analysis of vitamin D metabolites. For quantitative analysis the dried blood spot on the sorption material is dissolved with an aqueous solvent buffer containing detergent, pH 7.0 to 10.0, and the vitamin D metabolites are eluted with a protic organic solution having a permittivity of less than 35. The eluate is analysed for vitamin D metabolites using conventional methods. | 2014-03-13 |
20140072989 | TSH IMMUNOASSAYS EMPLOYING SCAVENGING REAGENTS FOR CROSS-REACTING ENDOCRINE GLYCOPROTEIN HORMONE ANALOGUES - Thyroid Stimulating Hormone (TSH) immunoassays are performed using an ELISA sandwich assay that employs scavenging or sacrificial beads for reducing interference caused by cross-reacting endocrine glycoprotein hormone analogues such as Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Chorionic Gonadotropin (CG). | 2014-03-13 |
20140072990 | FLUORESCENT SUBSTRATE FOR DETECTION OF ENZYMATIC ACTIVITY OF NITRILE-RELATED ENZYME - The object of the present invention is to provide a fluorescent substrate for detecting the enzymatic activity of a nitrile-related enzyme. | 2014-03-13 |
20140072991 | QUANTITATIVE STANDARD FOR MASS SPECTROMETRY OF PROTEINS - The present invention provides a method of determining the absolute amount of a target polypeptide in a sample, said method comprising the following steps: (a) adding (aa) a fusion polypeptide to said sample, said fusion polypeptide comprising (i) at least one tag sequence and (ii) a subsequence of the target polypeptide; and (ab) a known absolute amount of a tag polypeptide comprising or consisting of said tag sequence according to (aa) to said sample, wherein said fusion polypeptide on the one hand is mass-altered as compared to said target polypeptide and said tag polypeptide on the other hand, for example, said fusion polypeptide on the one hand and said target polypeptide and said tag polypeptide on the other hand are differently isotope labeled; (b) performing proteolytic digestion of the mixture obtained in step (a); (c) subjecting the result of proteolytic digestion of step (b), optionally after chromatography, to mass spectrometric analysis; and (d) determining the absolute amount of said target polypeptide from (i) the peak intensities in the mass spectrum acquired in step (c) of said fusion polypeptide, said tag polypeptide and said target polypeptide and (ii) said known absolute amount of said tag polypeptide. | 2014-03-13 |
20140072992 | Di- and Poly-Ubiquitin Deubiquitinase Substrates and Uses Thereof - Methods for detection of the activity of proteolytic enzymes, particularly isopeptidases, are disclosed. | 2014-03-13 |
20140072993 | SENSOR PROBE FOR BIO-SENSING AND CHEMICAL-SENSING APPLICATIONS - The basic structure and functionality of a probe as disclosed herein allows for flexibly incorporating into the probe, various sensing elements for various sensing applications. Two example applications among these various sensing applications include bio-sensing and chemical-sensing applications. For bio-sensing applications the probe, which is fabricated upon a silicon substrate, includes a bio-sensing element such as a nano-pillar transistor, and for chemical-sensing applications the probe includes a sensing element that has a functionalized contact area whereby the sensing element generates a voltage when exposed to one or more chemicals of interest. | 2014-03-13 |
20140072994 | METHODS OF ANAEROBIC DIGESTION OF BIOMASS TO PRODUCE BIOGAS - Improved methods for anaerobic digestion of organic matter to produce biogas. Among the improvements given are including ferric iron in a hydrolysis reactor to increase the rate and efficiency of anaerobic hydrolysis to provide substrates for methanogenesis. A solids separation step is added after hydrolysis and before methanogenesis to improve the efficiency of the methanogenesis step. Other improvements involve using separate tanks for the hydrolysis and methanogenesis stages and using two (or more) methanogenesis tanks in sequence, and switching the order of the two (or more) methanogenesis tanks periodically. | 2014-03-13 |
20140072995 | Modulators of ATP-Binding Cassette Transporters - The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators. | 2014-03-13 |
20140072996 | METHODS AND KITS FOR DETECTING HEMOGLOBIN IN TEST SAMPLES - The present invention relates to methods of detecting hemoglobin in a test sample. These methods can be used to diagnose a subject suffering from a genetic disorder relating to hemoglobin metabolism, to determine the eligibility of a subject to be a blood donor, to determine the age of a stored blood sample or to identify a hemolyzed plasma sample. The present invention also relates to kits for use in the above described methods. | 2014-03-13 |
20140072997 | SYSTEM AND METHOD FOR DEPOSITING PARTICLES ON A DISC - A system and method are disclosed in which particles sorted by a flow cytometer may be deposited directly into a deposition layer formed on the surface of an optical disc, and information regarding measurements made of the particle, as well as the storage location of the particle, can be written to the recording layer of the optical disc. | 2014-03-13 |
20140072998 | SYSTEM AND METHOD FOR AUTOMATICALLY VENTING AND SAMPLING A CULTURE SPECIMEN CONTAINER - Apparatus for automated venting and/or sampling of a specimen container having a closure sealing the interior of the specimen container from the environment is disclosed. The apparatus includes a rack holding the specimen container; a venting and/or sampling device having a needle, a chamber in fluid communication with the needle and a port in fluid communication with the chamber; a robotic transfer mechanism moveable relative to the rack; a sample removal apparatus attached to the robotic transfer mechanism having gripping features for gripping the venting device. The sample removal apparatus and robotic transfer mechanism are moveable relative to the specimen container so as to automatically insert the needle of the venting device through the closure of the specimen container to thereby vent the interior of the specimen container and obtain equilibrium between the interior of the specimen container and the atmosphere and withdraw a portion of the sample from the specimen container into the venting and/or sampling device. | 2014-03-13 |
20140072999 | METHODS OF SIMULATING CHEMOTHERAPY FOR A PATIENT - The present invention provides methods for predicting or modeling a chemotherapy outcome for a given patient, to assist physicians in the selection of chemotherapeutic agents for individualized cancer treatment. | 2014-03-13 |
20140073000 | METHODS AND MEANS FOR MANIPULATING PARTICLES - The present invention is concerned with a system for sorting target particles from a flow of particles. The system has a microscope, a light source, a CCD camera, microfluidic chip device with microfluidic channels, a detection apparatus for detecting the target particles with predefined specific features, a response generating apparatus for generating a signal in response to the detection of the target particles, and an optical tweezing system for controlling movement of optical traps, the optical tweezing system is operably linked to the response signal. | 2014-03-13 |
20140073001 | Method for Detection or Identification of Bacteria or Bacterial Spores - A method and apparatus for detecting bacteria and bacterial spores are disclosed in which a sample is assessed for the presence of bacteria and/or bacterial spores by reference to horizontally polarized fluorescent light. | 2014-03-13 |
20140073002 | METHOD FOR DETERMINING DIFFERENTIATION LEVEL OF PLURIPOTENT STEM CELLS - The present invention provides a method for determining differentiation level of pluripotent stem cell, comprising a step of determining a flatness of cultured pluripotent stem cell, wherein the flatness is an indication. | 2014-03-13 |
20140073003 | METHOD FOR STAINING A HISTOLOGICAL SAMPLE, AND AUTOMATED STAINER - The invention relates inter alia to an automated stainer for staining, in particular for hemalum-eosin (HE) staining, of a histological sample, the automated stainer exposing the sample to the action of at least one stain using at least one staining parameter. The automated stainer is notable for the fact that the automated stainer comprises an input means with which a staining parameter is definable, in particular is inputtable or is selectable from a plurality of possible staining parameters; and that a control apparatus is present which, upon application of the defined staining parameter, ascertains the prospectively expectable outcome of an action and displays it to the user with a display apparatus, before the automated stainer actually stains the sample. | 2014-03-13 |
20140073004 | MICROTOME SECTIONABLE GEL SUPPORT STRUCTURE AND METHODS - A sectionable tissue sample support structure including a gel compound formed into a self supporting geometric shape for retention and orientation of at least one tissue sample during a histopathology process including processing, embedding and microtome slicing of the tissue sample. A method of orienting, processing, embedding and microtome slicing a tissue sample using a gel compound preformed into a self supporting geometric shape. A combination including the sectionable tissue sample support structure and a package containing the sectionable tissue sample support structure. | 2014-03-13 |
20140073005 | Fusion Constructs and Use of Same to Produce Antibodies with Increased Fc Receptor Binding Affinity and Effector Function - The present invention relates to the field of glycosylation engineering of proteins. More particularly, the present invention relates to nucleic acid molecules, including fusion constructs, having catalytic activity and the use of same in glycosylation engineering of host cells to generate polypeptides with improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function. | 2014-03-13 |
20140073006 | METHODS USING A PROGRESSIVE CAVITY PUMP BIOREACTOR - Methods of using a progressive cavity pump as a bioreactor are disclosed. Methods of isolating a biological product, such as pancreatic islet cells, using the bioreactor are also disclosed. | 2014-03-13 |
20140073007 | SCREENING AND ENRICHMENT SYSTEM FOR PROTEIN EXPRESSION IN EUKARYOTIC CELLS USING A TRICISTRONIC EXPRESSION CASSETTE - The present invention provides a polynucleotide and a method for screening and enriching a recombinant protein expressed in a eukaryotic cell, the polynucleotide comprising a tricistronic expression cassette comprising a) a promoter, b) a gene of interest (GOI), c) a reporter gene, d) a selection marker gene, e) an internal ribosome entry site (IRES) element, and f) a 2A element. Said method comprises a) transfecting or transducing suitable eukaryotic host cells with the polynucleotides of the present invention, b) culturing the eukaryotic host cells under conditions so as to express the protein of interest, the reporter protein and the selection marker protein in a cell culture selection medium suitable for selecting positively-transfected/transduced cells by means of said selection marker, and c) screening, sorting and/or enriching the cells expressing high levels of protein of interest by means of the reporter protein. | 2014-03-13 |
20140073008 | GENE CLUSTER FOR BIOSYNTHESIS OF CYCLOCLAVINE - The invention in principle pertains to the field of recombinant manufacture of alkaloids and, in particular, cycloclavine. It provides polynucleotides for the gene cluster of enzymes involved in the biosynthesis of cycloclavin as well as vectors and host cells comprising such polynucleotides. Also provided are polypeptides encoded by the said polynucleotides which can be applied in a method for the manufacture of cycloclavine also encompassed by the present invention. | 2014-03-13 |
20140073009 | Methods for Producing Secreted Polypeptides - The present invention relates to methods for producing a polypeptide comprising using a signal peptide foreign to the polypeptide, nucleic acid constructs comprising a first and a second nucleotide sequence encoding the signal peptide and the polypeptide and expression vectors and host cells comprising said nucleic acid construct. The signal peptide is the LQ2 peptide which is a hybrid of sequence from the signal peptide of alpha amylase from | 2014-03-13 |
20140073010 | Methods of Modifying Eukaryotic Cells - A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification. | 2014-03-13 |
20140073011 | METHOD FOR THE PRODUCTION OF AQUEOUS NUTRIENT SOURCE FOR ALGAE AQUACULTURE FARMING - Method for the production of aqueous nutrient source for macro and micro algae aquaculture farming and nutrient source thus formed. Phosphorous containing rocks are dissolved in at least one mineral acid to yield a solution containing a blend of ions of the minerals included in the rocks and in the acid in a form digestible by the algae and adding carbon in the form of CO | 2014-03-13 |
20140073012 | ENHANCED CELLULOSE DEGRADATION - The present disclosure provides compositions and methods related to the degradation of cellulose and cellulose-containing materials. CDH-heme domain polypeptides and GH61 polypeptides and related polynucleotides and compositions are provided herein. Additionally, methods related to CDH-heme domain polypeptides, GH61 polypeptides, and related polynucleotides and compositions, are provided herein | 2014-03-13 |
20140073013 | ULTRAFAST THERMAL CYCLER - This disclosure provides thermal cyclers, systems, and methods of thermally cycling a sample. | 2014-03-13 |
20140073014 | Transcription Activator-Like Effector Assembly - Described herein are techniques for assembling a polynucleotide encoding a transcription activator-like effector nucleases (TALEN). The techniques ligate and digest necessary modules for a TALEN assembly in one reactor or system. Methods and Kits for generating a TALEN are also described. | 2014-03-13 |
20140073015 | Transcription Activator-Like Effector Assembly - Described herein are techniques for assembling a polynucleotide encoding a transcription activator-like effector nucleases (TALEN). The techniques ligate and digest necessary modules for a TALEN assembly in one reactor or system. Methods and Kits for generating a TALEN are also described. | 2014-03-13 |
20140073016 | Treatment - The present invention relates to a method for treating a lignocellulose biomass in order to dissolve the lignin therein, while the cellulose does not dissolve. The cellulose pulp obtained can be used to produce glucose. In addition the lignin can be isolated for subsequent use in the renewable chemical industry as a source for aromatic platform chemicals. | 2014-03-13 |
20140073017 | CELLULASE COMPOSITIONS AND METHODS OF USING THE SAME FOR IMPROVED CONVERSION OF LIGNOCELLULOSIC BIOMASS INTO FERMENTABLE SUGARS - The present invention relates to compositions that can be used in hydrolyzing biomass such as compositions comprising a polypeptide having β-glucosidase activity, methods for hydrolyzing biomass material, and methods for improving the stability and saccharification efficacy of a composition comprising such β-glucosidase polypeptides and/or activity. | 2014-03-13 |
20140073018 | Method for Preparation of Carbamic Acid (R)-1-Aryl-2 Tetrazolyl-Ethyl Ester - Disclosed is a method for the preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl esters, comprising the enantioselective enzyme reduction of a 1-aryl-2-tetrazolyl-ethyl ketone to form a (R)-1-aryl-2-tetrazolyl-ethyl alcohol and the carbamation of said alcohol. | 2014-03-13 |
20140073019 | GENETICALLY MODIFIED CELL AND PROCESS FOR USE OF SAID CELL - The present invention relates to the field of biotransformation of furanic compounds. More particular the present invention relates to novel genetically modified cells with improved characteristics for biocatalytic transformation of furanic compounds and a vector suitable for the genetic modification of a host cell. Further aspects of the invention are aimed at processes for biotransformation of 5-(hydroxymethyl)furan-2-carboxylic acid (HMF-acid) and its precursors with the use of the cell according to the invention. | 2014-03-13 |
20140073020 | Sclareol and labdenediol diphosphate synthase polypeptides, encoding nucleic acid molecules and uses thereof - Provided are labdenediol diphosphate synthase polypeptides, sclareol synthase polypeptides, nucleic acid molecules encoding the labdenediol diphosphate synthase polypeptides and sclareol synthase polypeptides, and methods of using the labdenediol diphosphate synthase polypeptides, sclareol synthase polypeptides. Also provided are methods for producing labdenediol diphosphate, sclareol and (−)-ambroxide. | 2014-03-13 |
20140073021 | PROCESSES AND SYSTEMS FOR THE PRODUCTION OF FERMENTATION PRODUCTS - The present invention relates to the production of fermentation products such as alcohols including ethanol and butanol, and processes employing in situ product removal methods. | 2014-03-13 |
20140073022 | PRODUCTION OF POLYHYDROXYALKANOATES WITH A DEFINED COMPOSITION FROM AN UNRELATED CARBON SOURCE - Cells and methods for producing polyhydroxyalkanoates. The cells comprise one or more recombinant genes selected from an R-specific enoyl-CoA hydratase gene, a PHA polymerase gene, a thioesterase gene, and an acyl-CoA-synthetase gene. The cells further have one or more genes functionally deleted. The functionally deleted genes include such genes as an enoyl-CoA hydratase gene, a 3-hydroxyacyl-CoA dehydrogenase, and a 3-ketoacyl-CoA thiolase gene. The recombinant cells are capable of using producing polyhydroxyalkanoates with a high proportion of monomers having the same carbon length from non-lipid substrates, such as carbohydrates. | 2014-03-13 |
20140073023 | GENERATION OF HYDROGEN FROM HYDROCARBON BEARING MATERIALS - Disclosed are strategies for the economical microbial generation of hydrogen, useful as an alternative energy source, from hydrocarbon-rich deposits such as coal, oil and/or gas formations, oil shale, bitumen, tar sands, carbonaceous shale, peat deposits and sediments rich in organic matter through the management of the metabolism of microbial consortia. | 2014-03-13 |
20140073024 | Phenylpyruvate Reductase and Method for Manufacturing Optically-Active Phenyllactic Acid and 4-Hydroxyl-Phenyllactic Acid Using Same Enzyme - The present invention provides a phenylpyruvate reductase for efficiently obtaining highly pure, optically active 3-phenyllactate and 4-hydroxyphenyllactate; a gene coding for the same; and a method for manufacturing optically active 3-phenyllactate and 4-hydroxyphenyllactate employing the same. | 2014-03-13 |
20140073025 | METHOD AND APPARATUS FOR RECYCLING AND REUSING BEVERAGES AND OTHER LIQUIDS AND CONTAINER MATERIALS - A system for destruction and recycling of containers (such as bottles, cans and the like), as well as associated liquids, food products or other residue, greatly reduces waste discharge and/or disposal requirements. Packaging and other solids are shredded, ground or otherwise processed, while associated liquids are collected. Evaporation removes water for reuse, thus concentrating sugars and other food materials for utilization as agricultural amendments or stock for bio-product production. Bio-fuels/solvents are generated, typically using an Immobilized Microbe Bioreactor system modified for fuels/solvents production. | 2014-03-13 |
20140073026 | SYSTEMS USING CELL CULTURE FOR PRODUCTION OF ISOPRENE - The invention features methods for producing isoprene from cultured cells. The invention also provides compositions that include these cultured cells. The invention provides isoprene compositions, such as compositions with increased amount of isoprene or increased purity. Additionally, the invention provides methods of producing isoprene by culturing cells under conditions suitable for isoprene production while maintaining cell viability and/or metabolic activity. | 2014-03-13 |
20140073027 | MICROFLUIDIC PHOTOPORATION - A cell permeabilizing micro fluidic system for permeabilizing one or more cells in a fluid flow. The system has a micro fluidic channel for channeling at least one cell in a fluid flow and an optical source for generating a beam of light for permeabilizing the at least one cell, wherein the channel and the source are arranged so that the light beam and fluid flow are collinear in a permeabilization part of the channel and cells are permeabilized within the permeabilization part. | 2014-03-13 |
20140073028 | MEK Ligands and Polynucleotides Encoding MEK Ligands - The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate MEK activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands, homopolyligands, and heteropolyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands and polyligands. | 2014-03-13 |
20140073029 | TARGETED PERHYDROLASES - Disclosed herein are compositions and methods to target enzymatic peracid production to a target surface. The peracid benefit agent produced by the targeted perhydrolytic enzyme can be use for a variety of applications such as bleaching, whitening, disinfecting, destaining, deodorizing, and combinations thereof. Specifically, a fusion protein comprising a perhydrolytic enzyme and at least one peptidic component having affinity for a target surface (excluding body surfaces and oral care surfaces) is used in combination with a suitable substrate and a source of peroxygen to enzymatically produce a peracid on or near the surface of the target material. In a preferred aspect, the target surface is a cellulosic material. | 2014-03-13 |
20140073030 | DETERGENT COMPOSITIONS CONTAINING BACILLUS AGARADHAERENS MANNANASE AND METHODS OF USE THEREOF - The present compositions and methods relate to an endo-β-mannanase cloned from | 2014-03-13 |