| 10th week of 2022 patent applcation highlights part 39 |
| Patent application number | Title | Published |
|---|
| 20220074883 | System and Method for Optimizing Insulin Dosages for Diabetic Subjects - A method and system for optimizing insulin dosages for diabetic subjects which includes a processor for calculating basal and bolus dosages to be recommended for meal types including breakfast, lunch, dinner, snack, or at miscellaneous times. The bolus calculations are specifically directed to time periods which are taken from either pre-meal, post-meal, bedtime, mid-sleep or miscellaneous times. The processor calculates an optimized bolus for a specific time period and meal type based upon prior basal dosages, prior glucose doses, hypoglycemia thresholds, mid-point of target ranges, and subject insulin sensitivity factors. A display is provided to the subject for sensing the optimized insulin dosage recommended at a specific time period and for a specific meal type. | 2022-03-10 |
| 20220074884 | GAS SENSOR - A gas sensor includes a solid electrolyte body with oxygen ion conductivity, a gas flow portion (ranging from a gas inlet port to a second inner cavity), a particular gas detector (including a main pump cell, a measurement pump cell, an auxiliary pump cell, etc.), and a control device. Prior to startup of the gas sensor, the control device sets electric power supplied to a heater such that a temperature difference between a temperature of the heater and a preset target temperature becomes zero, and determines, on the basis of the set electric power, whether temperature raising control of supplying the set electric power to the heater is to be executed. | 2022-03-10 |
| 20220074885 | GAS SENSOR - A gas sensor includes a solid electrolyte body with oxygen ion conductivity, a resistance heating element imbedded in the solid electrolyte body, a gas flow portion provided in a fore end portion of the solid electrolyte body, a particular gas detector detecting particular gas in measurement object gas introduced to the gas flow portion and a controller setting, prior to startup of the gas sensor, electric power supplied to the resistance heating element such that a temperature in the fore end portion becomes equal to a preset target temperature, and determining, on basis of a temperature rise speed in the fore end portion when the set electric power is supplied to the resistance heating element, whether temperature raising control of supplying the set electric power to the resistance heating element is to be continued. | 2022-03-10 |
| 20220074886 | LIMITING CURRENT GAS SENSOR AND MANUFACTURING METHOD THEREOF - Provided is a limiting current gas sensor including a first porous electrode including a main surface; a plurality of solid electrolyte islands provided on the main surface of the first porous electrode and separated from each other; and a second porous electrode provided on the plurality of solid electrolyte islands, in which the first porous electrode is provided across the plurality of solid electrolyte islands, the second porous electrode is provided across the plurality of solid electrolyte islands, and a maximum size of each of the plurality of solid electrolyte islands in plan view of the main surface is equal to or smaller than 50√2 μm. | 2022-03-10 |
| 20220074887 | GAS SENSOR ELEMENT AND GAS SENSOR - A gas sensor element includes a solid electrolyte body, a first electrode, a second electrode, and a protective layer. The protective layer includes at least a first catalyst layer that supports a first catalyst metal other than a metal facilitating a reduction reaction of nitrogen oxide and a second catalyst layer that supports only a second catalyst metal facilitating the reduction reaction of the nitrogen oxide. The first catalyst layer and the second catalyst layer are arranged in a path through which a gas under measurement is supplied from the outside of the gas sensor element to the first electrode in such a manner that the first catalyst layer and the second catalyst layer are not in direct contact with each other. | 2022-03-10 |
| 20220074888 | GAS SENSOR - A gas sensor includes a sensor element, a housing, a contact terminal, a second insulator, a lead wire, a sealing member, an inner periphery side cover and an outer periphery side cover. The inner periphery side cover is mounted on an outer periphery at a position on a base end side in an axial direction of the housing. The outer periphery side cover is disposed on the outer periphery side of the inner periphery side cover, forms a substantially cylindrical space with the inner periphery side cover and holds the sealing member on an inner periphery side. | 2022-03-10 |
| 20220074889 | Device and Method for Biomolecule Measurement - Particles of a sustained-release gel which is converted into a sol by reacting with a product produced by a reaction of biomolecules with an enzyme, are disposed on a measurement unit, and a measurement target biomolecule is brought into contact with the particles. Due to this contact, a product is produced according to a reaction of the biomolecule with the enzyme contained in the particles. According to the reaction with the produced product, the sustained-release is converted into a sol, and a plurality of contained detection molecules are released to the outside of the particles. | 2022-03-10 |
| 20220074890 | SYSTEM HAVING A PRE-SEPARATION UNIT - There is provided a system ( | 2022-03-10 |
| 20220074891 | Systems and Methods for Two-Dimensional Mobility Based Filtering of Ions - A system for separating ions includes first and second surfaces extending along first and second perpendicular directions, an ion channel defined between the surfaces and configured to receive a stream of ions, first and second electrode arrays each including a plurality of electrodes extending in a third direction and respectively associated with the first and second surfaces, means for causing gas to flow across the ion channel in a fourth direction substantially opposite the first direction, and a controller configured to apply a DC voltage gradient to the electrode arrays. The electrode arrays are configured to generate an electric field based on the DC voltage gradient. The electric field and the flow of gas are configured to direct ions having mobilities in a first mobility range along a first path and ions having mobilities in a second mobility range along a second path. | 2022-03-10 |
| 20220074892 | METHOD OF CHARACTERISING MOLECULES BY ION-MOBILITY SPECTROMETRY - A method of identifying and/or characterizing ions comprises separating analyte ions according to a first physico-chemical property (ion-mobility), selecting first ions of the analyte ions, and activating, fragmenting or reacting the first ions to produce first product ions, separating the first product ions according to the first physico- chemical property, and determining a pattern of the first product ions. The first ions are identified and/or characterized using the pattern of the first product ions. | 2022-03-10 |
| 20220074893 | DETECTING STRESS-STRAIN IN METAL COMPONENTS - A system for detecting and quantifying changes in the stress-strain state of a ferrous structure includes an exciter coil system is positioned to generate an AC magnetic field that couples into the ferrous structure. A detector apparatus is positioned relative to the excited to detect an eddy current magnetic field resulting from the AC magnetic field generated by the exciter coil system. An analyzer compares the eddy current magnetic field parameters detected by the detector apparatus with the direct AC magnetic field transmitted by the exciter coil system and correlates changes in the parameters of the eddy current magnetic field with the stress-strain on the ferrous structure. | 2022-03-10 |
| 20220074894 | SAW-BASED HYDROGEL TESTING FOR DETECTING VIRUSES OR OTHER ANTIGENS - An apparatus includes a surface acoustic wave (SAW) sensor. The SAW sensor includes a piezoelectric substrate. The SAW sensor also includes first and second interdigitating transistors over the piezoelectric substrate. The first interdigitating transistor is configured to convert an input electrical signal into an acoustic wave. The second interdigitating transistor is configured to convert the acoustic wave into an output electrical signal. The piezoelectric substrate is configured to transport the acoustic wave. The SAW sensor further includes a detection layer over the piezoelectric substrate and positioned at least partially between the first and second interdigitating transistors. The detection layer includes (i) antibodies configured to bind to one or more biological analytes and (ii) a hydrogel layer over the antibodies. | 2022-03-10 |
| 20220074895 | BONDING LAYER EVALUATION SYSTEM AND BONDING LAYER EVALUATION METHOD - A bonding layer evaluation system includes an elastic wave generation device configured to generate an elastic wave from a sample including a bonding layer; an elastic wave reflection body configured to reflect the elastic wave generated from the sample; a sample installation unit provided between the elastic wave generation device and the elastic wave reflection body; an elastic wave detection device disposed in a direction in which the elastic wave is reflected by the elastic wave reflection body, and configured to detect the reflected elastic wave; and a control device configured to evaluate a parameter related to the bonding layer. The control device evaluates the parameter related to the bonding layer by comparing the actual value of the elastic wave detected by the elastic wave detection device with a theoretical value of the elastic wave calculated based on a theoretical model related to the sample. | 2022-03-10 |
| 20220074896 | Apparatus and Method of Detecting Anomalies in an Acoustic Signal - An apparatus for detecting anomalies in an acoustic signal, the apparatus including: one or more microphones for receiving an acoustic signal of an environment; and a processor implementing: an acoustic signal processing module configured to: analyse the acoustic signal to identify anomalies in the acoustic signal indicative of events occurring in the environment; and classify the anomalies in the acoustic signal into one or more event classifications; and a communications module configured to output the one or more event classifications, wherein the apparatus is located in the environment and includes an environmental enclosure arranged to house the processor and to protect the processor from environmental contaminants. | 2022-03-10 |
| 20220074897 | GAS CONCENTRATION DETECTION BY MEANS OF THERMOACOUSTIC SOUND WAVE - A gas sensor having a heater, a receiver, and a space arranged between the heater and the receiver, is described, the heater being configured to generate a thermoacoustic sound wave propagating through the space by using a stimulation signal. The receiver is in this case configured to receive the thermoacoustic sound wave that has propagated through the space and to convert it into a reception signal that has a time-of-flight-dependent shift with respect to the stimulation signal and therefore information relating to the gas concentration in the space. | 2022-03-10 |
| 20220074898 | HEATER INTEGRATED GAS CHROMATOGRAPHY COLUMN DEVICE - A heater integrated gas chromatography (GC) column device according to the present invention is capable of precisely and uniformly controlling a temperature by having a high thermal conductivity, and raising and lowering a temperature at a high speed by having a low thermal mass, such that a measuring time is significantly decreased. The GC column is in contact with a bobbin with a homogeneous temperature distribution, and thus a temperature is homogeneously distributed in each GC column. Further, the heater integrated GC column device according to the present invention has the above-described effects and may have a smaller size. | 2022-03-10 |
| 20220074899 | MICRO-SEPARATOR HAVING STATIONARY PHASE WITH THREE-DIMENSIONAL NANO-STRUCTURE AND METHOD FOR MANUFACTURING THE SAME - A disclosed micro-separator for gas chromatography includes a base substrate having a trench, a channel column disposed in the trench, and a cover member combined with the base substrate and covering the channel column. The channel column includes a stationary phase having pores ordered and three-dimensionally connected to each other. | 2022-03-10 |
| 20220074900 | Monitoring mycotoxins and its metabolites in the blood of pigs or broiler chickens - The present invention relates to a multi-screening method for the detection of a large number of mycotoxins and metabolites in broiler chickens and pigs, the method comprising collecting the blood of broiler chickens and pigs as a dried blood sample, preparing the dried blood sample for analysis and analyzing the prepared dried blood sample by a two-step liquid chromatography-tandem mass spectrometry LC-MS/MS process. In a first LS-MS/MS step, for a given mobile phase for the LC process, the mass spectrometer operates in negative electro-spray ionization mode, and for another mobile phase for the LC process, the mass spectrometer operates in positive electro-spray ionization mode. Such method can advantageously be used for screening and assessing the exposure of pigs or broiler chickens to feed contaminated with mycotoxins. Also, such method can be used for assessing the impact of the addition of mycotoxin detoxifying agents to animal feed. | 2022-03-10 |
| 20220074901 | LIQUID CHROMATOGRAPH MASS SPECTROMETER - The invention provides a liquid chromatograph mass spectrometer which prevents contamination of a pump and a column and can perform mass calibration without adding a complicated mechanism. This liquid chromatograph mass spectrometer includes a liquid chromatograph including a liquid feed pump configured to feed a mobile phase solvent, a mass spectrometer configured to analyze a mass of a sample, and a standard sample container configured to be connected in series with the liquid chromatograph and the mass spectrometer in a flow path that connects the liquid chromatograph and the mass spectrometer and configured to house a standard sample for mass calibration. | 2022-03-10 |
| 20220074902 | DETECTION METHOD, ANALYSIS METHOD, ANALYSIS DEVICE AND NON-TRANSITORY COMPUTER READABLE MEDIUM - A detection method includes acquiring at least one first relative response factor obtained by measurement of a sample having a same component as at least one component included in a subject sample at a known concentration and a sample having at least one compound at a known concentration, or at least one first threshold value based on each of the at least one first relative response factor, measuring the subject sample and a sample including the at least one compound, and calculating at least one second relative response factor in regard to at least one component of the subject sample and the at least one compound, and producing first information in regard to a change in concentration of the subject sample based on the at least one first relative response factor or the at least one first threshold value, and the corresponding at least one second relative response factor. | 2022-03-10 |
| 20220074903 | SENSING DEVICES AND CALIBRATION METHOD THEREOF - A sensing device is provided. The sensing device includes a processing circuit and a multi-sensor integrated single chip. The multi-sensor integrated single chip includes a substrate and a temperature sensor, a pressure sensor, and an environmental sensor disposed on the substrate. The temperature sensor senses temperature. The pressure sensor senses pressure. The environmental sensor senses an environmental state. The processing circuit obtains a first sensed temperature value from the temperature sensor when the environmental sensor does not operate, and it obtains a second sensed temperature value from the temperature sensor when the environmental sensor operates. The processing circuit obtains a sensed pressure value from the pressure sensor. The processing circuit obtains at least one temperature calibration reference of the pressure sensor according to the first and second sensed temperature values and calibrates the sensed pressure value according to the temperature calibration reference. | 2022-03-10 |
| 20220074904 | QUANTIFYING METHOD OF UNCERTAINTY OF MEASURED VALUE BY CLOSE MATCH SPAN CALIBRATION OF MEASURING SENSOR AND THE APPARATUS USING THE SAME - Disclosed herein is a quantifying method of uncertainty of measured value by close match span calibration of measuring sensor comprising a step of:
| 2022-03-10 |
| 20220074905 | Oxygen Sensor for High Temperature Kilns and Method of Fabrication - An oxygen sensor for a gas, coal, oil or wood fired kiln that is orders of magnitude cheaper than the current state of the art oxygen sensors. It uses a TiO | 2022-03-10 |
| 20220074906 | DEVICE AND METHOD FOR MEASURING RADON RELEASE AMOUNT DURING ROCK SHEARING DAMAGE PROCESS - The disclosure provides a device and method for measuring radon release amount during rock shearing damage process. The method includes: the sealed chamber where the rock sample placed is vacuumed in the first place, and then the radon released during rock sample shearing damage process is all collected into the radon collection box, and then the concentration of the radon collected in the radon collection box is measured with a radon concentration measure instrument, so that the purity of the radon collected in the radon collection box can be ensured, and thus the accuracy of the concentration of radon measured by the radon concentration measure instrument can be ensured, and the device and method have good practicability. | 2022-03-10 |
| 20220074907 | FOCUSING AGENTS AND METHODS OF USING SAME - A method for reducing the variability, as measured by relative standard deviation (RSD), of an analytical testing technique is provided. This improvement in RSD improves the confidence in the values obtained during field testing. The method includes incorporating a focusing agent into the sampling media, which permits providing sampling media such as thermal desorption tubes preloaded with the focusing agent. | 2022-03-10 |
| 20220074908 | GROWTH MONITORING SYSTEM - The present disclosure is directed to collecting and evaluating plant growth data and to making estimates from the plant growth data. Estimates that may be made from the plant growth data identify a total volume or mass of plant matter that is projected to be yielded from cannabis plants growing at one or more farms. Estimates made by methods and apparatus consistent with the present disclosure may identify a mass or volume of cannabis concentrates that could be created by an extraction process that extracts cannabinoids from an volume of cannabis plant matter. Methods and apparatus consistent with the present disclosure may also allow a computer of a manufacturer to receive data from either a grower computer or from a computer of an extractor such that a manufacturer can arrange to purchase cannabinoid containing extracts that may be incorporated into products that may be consumed or used by a person. | 2022-03-10 |
| 20220074909 | BOTTLE WITH SENSORS FOR PROBING AND OPTIMIZING BOTTLING LINE PERFORMANCE - A bottle with sensors for probing and optimizing bottling line performance is disclosed. According to one embodiment a bottle, comprises an outer layer and a reservoir tube inside the outer layer that connects a reservoir inside the outer layer to a neck of the bottle. The bottle has a battery inside the outer layer and one or more sensors powered by the battery. | 2022-03-10 |
| 20220074910 | SYSTEM AND METHOD OF MEASURING GRAIN ORIENTATIONS - A system and a method of measuring grain orientations of a metal component. The method includes defining a series of measurement locations on the metal component at which to take a series of measurements indicative of grain orientations at corresponding measurement locations. The method further includes defining a nominal grain orientation at each measurement location. The method further includes loading the measurement locations into a computer-controllable fixture suitable for positioning the metal component. The method further includes locating the metal component in the computer-controllable fixture. The method further includes taking the series of measurements at the series of measurement locations. The method further includes analysing the measurement at each measurement location relative to the nominal grain orientation at the corresponding measurement location. | 2022-03-10 |
| 20220074911 | METHOD FOR HANDLING MELT SAMPLES IN A STEELWORKS LABORATORY, AND STEELWORKS LABORATORY - A method for the handling of melt samples in a steelworks laboratory may involve processing and/or analyzing a melt sample in at least one first treatment apparatus and subsequently transporting the melt sample via at least one first transport path to at least one second treatment apparatus where the melt sample is subjected to further processing and/or analysis. As part of the transporting step, the method may involve clamping the melt sample on a sample carrier so that the sample carrier is transported together with the clamped-in melt sample between the treatment apparatuses and is positioned in the treatment apparatuses for processing and/or analysis. | 2022-03-10 |
| 20220074912 | DRY-DEPOSIT TRACE EXPLOSIVES DISPENSING DEVICES AND TESTING SYSTEMS - Various embodiments of the present invention are directed towards a system and method to dispense an explosive compound onto a substrate. An example device includes a solvent having the explosive compound dissolved in the solvent to form a sample. A delivery mechanism dispenses the sample in a dispersed manner to sufficiently vaporize the solvent to prevent wicking while dispersing a residue of the explosive compound on the substrate to enable detection by explosive detection tools. | 2022-03-10 |
| 20220074913 | SYSTEMS AND APPARATUSES FOR SOIL AND SEED MONITORING - A system that is able to vary a depth of a row cleaner by adjusting a downforce applied to the row cleaner to promote planting at a desired seed depth and soil moisture. | 2022-03-10 |
| 20220074914 | SYNTHETIC AGRICULTURAL SENSOR - In order to predict plant stresses at a localized level, data feeds from many sensor types can be fused and analyzed to create a synthetic sensor estimating plant water stress, predicting microclimatic conditions, and performing localized plant disease and pest modeling. To make this affordable, an array of low-cost, lower precision sensors can be used. Sensor fusion is used to improve the accuracy of each sensing element by using machine learning to fuse data from the other sensing elements in the array. Additionally, machine learning can create a “synthetic sensor” replicating the output of high-cost and maintenance intensive sensing devices by using machine learning to replicate their output. | 2022-03-10 |
| 20220074915 | DEVICE AND METHOD FOR PREPARING NATURAL GAS HYDRATE UNDER CONTROLLED TEMPERATURE AND PRESSURE - The present disclosure provides a device and a method for preparing natural gas hydrate under controlled temperature and pressure, which relates to the technical field of rock and soil mechanics test technology and equipment. The device includes a three-axis cylinder outer tube, a temperature adjustment system, a pressure loading system, a gas supply system and a recovery system. The three-axis cylinder outer tube is provided with an accommodating cavity throughout its middle, and the accommodating cavity is provided with an end cover of the three-axis cylinder outer tube at each end thereof. The temperature adjustment system is used to adjust the temperature of the three-axis cylinder outer tube. The pressure loading system is used to apply pressure load to the accommodating cavity. The gas supply system is used to supply a high-pressure gas into the accommodating cavity. The recovery system is used to recover the moisture and gas in the accommodating cavity. | 2022-03-10 |
| 20220074916 | GREASE EVALUATION - Methods of evaluating viscous compositions are disclosed. The methods may be used to evaluate degradation levels of lubricants including grease. The methods may include preparing a surface for testing by leveling and flattening a viscous composition, placing a drop of a liquid on the flattened leveled surface, evaluating the observed contact angle between the drop and the surface, and then comparing the observed contact angle to a reference contact angle. | 2022-03-10 |
| 20220074917 | SPECTROSCOPIC METHOD AND APPARATUS FOR DETECTION OF VIRUSES AND OTHER BIOLOGICAL PATHOGENS - The presence of a virus, such as a coronavirus, or other pathogen can be determined through spectroscopic methods. In one example, the method includes obtaining a biological sample from a subject and obtaining spectrographic data from the sample in an onsite portable spectroscopic unit. The spectroscopic data may be transmitted to a remote lab to determine the presence of the virus or other pathogen within the sample, providing a simple to understand result that does not require significant interpretation by a medical practitioner Contrary to existing test methods such as PCR, this method has no supply chain requirements other than distilled water and results are out in real-time at a highly subdued cost. | 2022-03-10 |
| 20220074918 | Toilet Tracking Timing of Excreta Events - A system and method for assessing toilet user health and wellness is disclosed. The system comprises a toilet bowl adapted to receive excreta from a user; a sensor which detects at least one property of the user or excreta and records a timestamp associated with the property; and a processor which analyzes the property and uses the time stamp to correlate the property with data from previous events to assess one or more health or wellness conditions; wherein the correlation of the date stamp comprises correlating events that take place during the same segment of the day. The method comprises providing a system comprising a toilet bowl adapted to receive excreta from a user; a sensor which detects at least one property of the user or excreta and records the time of the excreta event; and a processor which analyzes the timing of excreta events and correlates the receiving excreta into the toilet bowl; obtaining data from the sensor and recording it; correlating data from separate events based on the time of day when the events occurred; and using the correlated data to monitor trends and analyze trends to assess the user's health and wellness. | 2022-03-10 |
| 20220074919 | Toilet Wastewater Collection and Testing - A method for collecting and testing an excreta sample from a user is disclosed. The system comprises a bowl having a volume of water for receiving excreta from a user, the excreta and water forming a volume of wastewater; a first sensor for detecting the addition of excreta to the water in the bowl; an orifice for collecting a sample of wastewater; wherein the sample is analyzed to determine a property of the excreta, which is used to obtain health and wellness information about the user. The method comprises providing a toilet comprising a bowl having a volume of water for receiving excreta from a user, the excreta and water forming a volume of wastewater; a first sensor for detecting the addition of excreta to the water in the bowl; an orifice for collecting a sample of wastewater; receiving excreta into the bowl; creation of wastewater through water contacting the excreta and excreta matter dispersing into the water; drawing a portion of the wastewater into the orifice to collect a sample of the wastewater; and testing the sample to gather health and wellness information about the user derived from the excreta matter in the wastewater. | 2022-03-10 |
| 20220074920 | APPARATUSES AND METHODS INVOLVING PROTEIN EXPLORATION THROUGH PROTEOLYSIS AND NANOPORE TRANSLOCATION - Embodiments in accordance with the present disclosure are directed to methods and apparatuses used for evaluating a protein in a sample using proteolysis and translocation. An example method includes isolating a single protein from a sample in a chamber having at least a first well and a second well separated from the first well by a membrane with a nanopore, the nanopore providing fluidic communication between the first and second wells. The single protein is cleaved into a plurality of peptide fragments via exposure to a protease in the first well, and translocated through the nanopore by applying an electric potential to the nanopore in the chamber after cleavage of the single protein by the protease. The method further includes detecting events indicative of the translocations of the plurality of peptide fragments through the nanopore and to the second well. | 2022-03-10 |
| 20220074921 | BLOOD STATE ANALYSIS APPARATUS, BLOOD STATE ANALYSIS SYSTEM, BLOOD STATE ANALYSIS METHOD, AND PROGRAM - A blood state analysis apparatus including at least an analysis unit that uses data related to the temporal change in electrical characteristics to analyze information related to fibrinogen in a blood sample, in which the analysis unit uses at least two predetermined time points derived from the data related to the temporal change on a basis of a predetermined mathematical definition to calculate a parameter R, and acquires at least two pieces of information related to the fibrinogen in the blood sample. | 2022-03-10 |
| 20220074922 | POLYMER MICROFILTERS, DEVICES COMPRISING THE SAME, METHODS OF MANUFACTURING THE SAME, AND USES THEREOF - A microfilter having a hydrophilic surface and suited for size-based capture and analysis of cells, such as circulating cancer cells, from whole blood and other human fluids is disclosed. The filter material is photo-definable, allowing the formation of precision pores by UV lithography. Exemplary embodiments provide a device that combines a microfilter with 3D nanotopography in culture scaffolds that mimic the 3D in vivo environment to better facilitate growth of captured cells. | 2022-03-10 |
| 20220074923 | METHODS OF IDENTIFYING PARKIN-MEDIATED MITOPHAGY ACTIVATING AGENTS - This disclosure provides a screening method to identify Parkin-mediated mitophagy activating agents wherein the method comprises contacting cells exogenously expressing labelled mutant Parkin polypeptide with a test agent and a mitophagy inducing agent, and measuring the amount of Parkin polypeptide recruited to mitochondria in the cells. Also provided is a kit comprising a plasmid, recombinant cells, a multi-well plate, a pintool head, cells expressing wildtype Parkin, and transfection reagents. | 2022-03-10 |
| 20220074924 | PERFORMING PHARMACODYNAMICS EVALUATIONS USING MICROFLUIDIC DEVICES - Microfluidic platforms including multiple microphysiological systems. At least one of the platforms include: at least one inlet; a plurality of organ constructs, each organ construct of the plurality of organ constructs being sized relative to other organ constructs of the plurality of organ constructs based on at least one predetermined human pharmacokinetic (PK) parameter; and a plurality of channels, each channel of the plurality of channels causing an organ construct of the plurality of organ constructs to be in fluidic communication with at least one other organ construct of the plurality of organ constructs. | 2022-03-10 |
| 20220074925 | SCREENING METHOD FOR SELECTED AMINO-LIPID-CONTAINING COMPOSITIONS - The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-dimethylaminomethyl-[1-3]-dioxolane by screening for an effect of the agent on the liver of a model subject. | 2022-03-10 |
| 20220074926 | SOLID-STATE INTEGRATED REAL-TIME OPTICAL MONITORING OF BIOCHEMICAL ASSAYS - The disclosed technology includes a planar device for performing multiple biochemical assays at the same time, or nearly the same time. Each assay may include a biosample including a biochemical, enzyme, DNA, and/or any other biochemical or biological sample. Each assay may include one or more tags including dyes and/or other chemicals/reagents whose optical characteristics change based on chemical characteristics of the biological sample being tested. Each assay may be optically pumped to cause one or more of luminescence, phosphorescence, or fluorescence of the assay that may be detected by one or more optical detectors. For example, an assay may include two tags and a biosample. Each tag may be pumped by different wavelengths of light and may produce different wavelengths of light that is filtered and detected by one or more detectors. The pump wavelengths may be different from one another and different from the produced wavelengths. | 2022-03-10 |
| 20220074927 | A Label-Free Detection Method for Characterization of the Behavior of a Component in a Liquid - The present disclosure relates to a method and system for label-free characterization of the behavior of a component in a complex liquid sample, which does not require pretreatment of either the complex liquid sample or the first component. | 2022-03-10 |
| 20220074928 | INTERFERENCE-SUPPRESSED PHARMACOKINETIC IMMUNOASSAY - Herein is reported a method for the determination of a bispecific antibody in a serum-containing sample comprising the steps of first incubating a solid phase to which a capture antibody specifically binding to the bispecific antibody has been immobilized with the sample to form an immobilized capture antibody-bispecific antibody-complex, thereafter incubating the solid phase with a replacement antibody that competes with the capture antibody for binding to the bispecific antibody and thereby forming a solution comprising a replacement antibody-bispecific antibody-complex, and determining in the solution the replacement antibody-bispecific antibody-complex. | 2022-03-10 |
| 20220074929 | QUANTIFICATION, ISOLATION, AND CHARACTERIZATION OF EXOSOMES USING DROPLET-BASED AND WELL-BASED MICROFLUIDIC SYSTEMS - Methods of quantification, isolation, and characterization of exosomes are provided. Exosomes can be quantified by contacting a sample with a capture bead comprising a bead and a first binding agent, and a second binding agent. The first binding agent binds to a first biomolecule in the exosomes to produce a first complex and the second binding agent binds to a second biomolecule in the exosomes of the first complex to produce a second complex. The first complexes and the second complexes are quantified based on a detectable signal conjugated to the second binding agent. A microwell or a droplet generation is utilized to quantify the first complexes and the second complexes. Quantifying the exosomes is used to diagnose a cancer in a subject. In such methods, the first and the second binding agents bind to cancer biomarkers present in the exosomes. | 2022-03-10 |
| 20220074930 | INTRA-DROPLET SURFACE ENGINEERING TO CAPTURE A MOLECULAR TARGET - The present invention relates to a method for capturing a molecular target present in the aqueous phase of a water-in-oil emulsion, said method being based on the use of a binding system comprising (a) a surfactant bearing a functional moiety on its hydrophilic head group and (b) a chemoprobe that acts as a molecular staple between the functionalized surfactant and the molecular target and comprises at least two distinct domains namely (i) at least one capture moiety which is able to specifically bind the molecular target and (ii) at least one binding domain which is able to interact with the functional group of the surfactant through covalent or non-covalent interactions, directly or through a binding intermediary. | 2022-03-10 |
| 20220074931 | METHODS OF ASSAYING PROTEINS - Methods and systems for identifying a protein within a sample are provided herein. A panel of antibodies are acquired, none of which are specific for a single protein or family of proteins. Additionally, the binding properties of the antibodies in the panel are determined. Further, the protein is iteratively exposed to a panel of antibodies. Additionally, a set of antibodies which bind the protein are determined. The identity of the protein is determined using one or more deconvolution methods based on the known binding properties of the antibodies to match the set of antibodies to a sequence of a protein. | 2022-03-10 |
| 20220074932 | SIZE-BASED PARTICLE SEPARATION AND CONCENTRATION USING PARTICLE SIZE AMPLIFICATION - Methods of using particle size amplification to facilitate size-based particle separation and concentration. At least one of the methods includes introducing a plurality of binding moieties into a fluid sample; allowing at least one of the binding moieties to bind two or more biological particles to form a particle cluster, in which the particle cluster comprises a first type of biological particle bound to a second different type of biological particle; and flowing the fluid sample comprising the particle cluster into a particle sorting region of a microfluidic device. | 2022-03-10 |
| 20220074933 | REFERENCE CASSETTE FOR FLUORESCENCE IMMUNOASSAY DIAGNOSTIC DEVICE - Provided in the present invention is a reference cassette for a fluorescence immunoassay diagnostic device, the cassette having, arranged in a case, fluorescent glass capable of maintaining fluorescence characteristics to be constant without causing degeneration, so as to accurately provide reference measurement information about the fluorescence detection amount during testing of the measurement accuracy of the fluorescence detection of the immunoassay diagnostic device, so that testing accuracy can improve, preventing decrease in measurement accuracy and being semi-permanently usable since the denaturation or deterioration of the fluorescent glass does not occur even if the cassette is used continuously, and providing a mask having a slit so as to limit the area of the fluorescent glass to be externally exposed to a specific area, thereby generating the type of fluorescence that is the same as that of a reaction area of a sample strip to be actually used, and thus more accurate reference measurement information can be provided. | 2022-03-10 |
| 20220074934 | SIGNAL AMPLIFICATION IN PLASMONIC SPECIFIC-BINDING PARTNER ASSAYS - The present invention relates to analyte detection devices and methods of using such devices to detect minute quantities of a target analyte in a sample. In particular, the invention provides an analyte detection device comprising a plurality of composite metallic nanostructures conjugated to analyte binding partners and a surface containing a metallic nanolayer on which a plurality of capture molecules is immobilized. Methods of preparing composite nanostructures are also described. | 2022-03-10 |
| 20220074935 | SYSTEMS AND METHODS OF DETERMINING HYGIENE CONDITION OF AN INTERIOR SPACE - A computer-implemented method for determining a hygiene condition of an interior space is described. The method has the steps of: a) obtaining relative abundance of at least one bacterium of human health concern in an interior space; b) generating a Microbial Index of Interior Space (“Microbial Index”) for the interior space based on the relative abundance; and c) displaying an output indicative of the Microbial Index for determining a hygiene condition of the interior space. The Microbial Index is characterized by a function of the relative abundance of the at least one bacterium of human health concern defined by F(Σ | 2022-03-10 |
| 20220074936 | ASSAYS FOR ANTIMICROBIAL ACTIVITY AND APPLICATIONS THEREOF - The disclosure provides methods, compositions, and kits for enhanced detection of microbes in samples and monitoring of antimicrobial activity in a subject. | 2022-03-10 |
| 20220074937 | MONOCLONAL ANTIBODY AGAINST CD19 ANTIBODY AND APPLICATION THEREOF - Provided are a monoclonal antibody against CD19 antibody and the application thereof. The monoclonal antibody which targets CD 19 antibody has high specificity and strong affinity. Also provided are a detection reagent with high sensitivity, good accuracy and good specificity for the detection of CAR-T cells and a detection method using the detection reagent, which may directly target an extracellular antigen-binding region on the CAR-T cell. | 2022-03-10 |
| 20220074938 | METHOD OF DETECTING PATHOGENS AND/OR ANTIGENS IN SAMPLES - The present disclosure provides new and improved methods for the detection of pathogens, for example viral pathogens, in samples. The methods, tests and assays permit the identification of an infection, for example a Coronavirus infection, in a sample, but can also be used as a means to identify the infectious status or “infectivity level” of a subject. Disclosed is a method for detecting an antigen in a sample, said method comprising: contacting the sample with an antigen binding agent, wherein the antigen binding agent is not an antibody. | 2022-03-10 |
| 20220074939 | METHOD FOR DETERMINING IMMUNE COMPETENCE AGAINST SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 - A method for determining immune competence against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) includes obtaining a blood sample from a subject in need thereof, detecting, in the blood sample, levels of binding antibodies against SARS-CoV-2 spike S1 protein and its receptor binding domain (RBD), and calculating a weighted value using a regression model. Another method for determining immune competence against SARS-CoV-2 is also disclosed. | 2022-03-10 |
| 20220074940 | METHOD OF DETECTING AN ENDOTOXIN USING LIMULUS AMEBOCYTE LYSATE SUBSTANTIALLY FREE OF COAGULOGEN - The present invention is related to a method of detecting an endotoxin in a sample using a chromogenic assay, the method comprising: (a) contacting the sample with a reagent comprising limulus amebocyte lysate (LAL) and a chromogenic substrate; and (b) measuring a chromogenic effect resulting from a change in the chromogenic substrate in the presence of endotoxin in the sample; wherein the LAL is substantially free of coagulogen. The method also relates to compositions and kits comprising LAL substantially free of coagulogen, and methods of making such. | 2022-03-10 |
| 20220074941 | HSP90 COMBINATION THERAPY - This invention concerns a method for selecting an inhibitor of a cancer-implicated pathway or of a component of a cancer-implicated pathway for coadministration, with an inhibitor of HSP90, to a subject suffering from a cancer which comprises the following steps: (a) contacting a sample containing cancer cells from a subject with an inhibitor of HSP90 or an analog, homolog or derivative of an inhibitor of HSP90 under conditions such that one or more cancer pathway components present in the sample bind to the HSP90 inhibitor or the analog, homolog or derivative of the HSP90 inhibitor; (b) detecting pathway components bound to the HSP90 inhibitor or to the analog, homolog or derivative of the HSP90 inhibitor; (c) analyzing the pathway components detected in step (b) so as to identify a pathway which includes the components detected in step (b) and additional components of such pathway; and (d) selecting an inhibitor of the pathway or of a pathway component identified in step (c). This invention further concerns a methods of treating a cancer patient by coadministering an inhibitor of HSP90 and an inhibitor of a cancer-implicated pathway or component thereof. | 2022-03-10 |
| 20220074942 | Diagnostic for Discriminating Benign Mass From Ovarian Cancer and Application Thereof - Useful, accessible, and predictive biomarkers for discriminating between ovarian cancer and benign adnexal masses are provided. Specifically, peptide biomarkers present in bodily fluid samples such as cervical-vaginal fluid (CVF) have been identified as having particularly robust diagnostic for identifying whether ovarian masses such as adnexal masses are benign, and ruling our ovarian cancer. The biomarker peptides disclosed herein therefore provide significantly enhanced sensitivity and specificity levels relative to extant methods for distinguishing benign ovarian masses from ovarian cancers. The biomarkers provide a timely and cost-efficient diagnostic capable of being used in a selection process to identify patients for whom treatment, which may include surgical resection and/or monitoring, may be performed by an obstetric gynecologist rather than a gynecologic oncologist. | 2022-03-10 |
| 20220074943 | COMPOSITION FOR DIAGNOSING BONE METASTASIS OF CANCER AND METHOD FOR DIAGNOSING BONE METASTASIS OF CANCER USING SAME - The present invention relates to a composition for diagnosing bone metastasis of cancer, a method for providing information needed for diagnosis of bone metastasis of cancer using same, a method for providing information needed for monitoring responses to treatment of bone metastasis of cancer using same, and a method for screening a therapeutic agent for bone metastasis of cancer using same. The composition for diagnosing bone metastasis of cancer of the present invention has the effect of effectively diagnosing bone metastasis of cancer at an early stage. | 2022-03-10 |
| 20220074944 | DETECTION OF BCL-2 FAMILY HETERODIMER COMPLEXES AND USE THEREOF - Immunoassays to detect the presence of Bcl-2 family heterodimeric complexes are described. The immunoassays are designed to detect one or more of BIM-Bcl-2, BIM-Bcl-xL, BIM-Mcl-1 and BAX-BAK heterodimers. The assays can be used, for example, to select a BH3 mimetic, or other drug targeting the apoptosis pathway, that is effective for treating a specific cancer, or to select a subject who is likely to respond to a particular BH3 mimetic. | 2022-03-10 |
| 20220074945 | CANCER ANTIGEN TARGETS AND USES THEREOF - The presently disclosed subject matter provides methods and compositions for treating myeloid disorders (e.g., acute myeloid leukemia (AML)). It relates to immunoresponsive cells bearing antigen recognizing receptors (e.g., chimeric antigen receptors (CARs)) targeting AML-specific antigens. | 2022-03-10 |
| 20220074946 | PEPTIDE ARRAY QUALITY CONTROL - The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research. | 2022-03-10 |
| 20220074947 | ANTIBODY EPITOPE - It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker. | 2022-03-10 |
| 20220074948 | PREDICTING T CELL EPITOPES USEFUL FOR VACCINATION - The present invention relates to methods for predicting T cell epitopes useful for vaccination. In particular, the present invention relates to methods for predicting whether modifications in peptides or polypeptides such as tumor-associated neoantigens are immunogenic and, in particular, useful for vaccination, or for predicting which of such modifications are most immunogenic and, in particular, most useful for vaccination. The methods of the invention may be used, in particular, for the provision of vaccines which are specific for a patient's tumor and thus, in the context of personalized cancer vaccines. | 2022-03-10 |
| 20220074949 | METHODS OF PREPARING SAMPLES FOR PROTEOMIC ANALYSIS - Provided herein are methods of preparing a protein sample for proteomic analysis. In exemplary embodiments, the method comprises (a) contacting a blood sample comprising proteins with a protective agent comprising an anticoagulant (AC) and an aldehyde releaser (AR), to obtain a mixture, optionally, wherein the blood sample is added to a blood collection tube (BCT) comprising the protective agent, and (b) isolating a fraction comprising proteins or a source of proteins from the mixture to yield a protein sample or a source of a protein sample, wherein steps of the method are carried out in the absence of exogenous proteolytic enzyme inhibitors, wherein the protein sample is suitable for proteomic analysis. Preferably, the protective agent consists of essentially (i) about 300 g/l to about 700 g/l imidazolidinyl urea; (ii) about 20 g/l to about 60 g/l glycine; and (iii) about 60 g/l to about 100 g/l EDTA; and the protein sample is analysed via mass spectrometry-based proteomic methods. | 2022-03-10 |
| 20220074950 | METHOD FOR DETECTING HOST CELL PROTEINS IN THERAPEUTIC ANTIBODIES BY COMBINING TRYPSIN DIGESTION, CHROMATOGRAPHY GRADIENTS, AND BOXCAR MASS SPECTROMETRY - The present disclosure provides an improved method for profiling the nature of undesirable host cell proteins (HCPs) in a therapeutic antibody preparation using an improved assay. The assay includes three (3) exemplary steps comprising: ultra-low trypsin digestion, long gradient liquid chromatography, and mass spectrometry (MS) using, in particular, BoxCar mass spectrometry. The disclosure allows for determining the purity of a therapeutic antibody such that it is suitable for use in patients. | 2022-03-10 |
| 20220074951 | COMPOSITIONS AND METHODS USEFUL IN DETECTING AND TREATING MULTIPLE SCLEROSIS AND OTHER DEMYELINATING DISEASES - Disclosed herein, are methods of detecting one or more microbes in a subject having or suspected of having a demyelinating disease including multiple sclerosis. Also, disclosed herein are methods of treating subjects who are developing or experiencing a worsening demyelination based on microbial detection. | 2022-03-10 |
| 20220074952 | Compositions and Methods to Detect Non-Coeliac Gluten Sensitivity - Disclosed are compositions and methods to detect proteins associated with non-coeliac gluten sensitivity (NCGS). Such markers may be useful to allow individuals susceptible to NCGS to manage their food intake to avoid symptoms and further progression of disease. | 2022-03-10 |
| 20220074953 | BIOMARKER LEVELS AND NEUROIMAGING FOR DETECTING, MONITORING AND TREATING BRAIN INJURY OR TRAUMA - Methods, compositions and kits useful in the detection, assessment, diagnosis, prognosis and/or treatment of brain injuries, especially mild traumatic brain injury (mTBI) or concussion, are based upon detection of changes in levels of certain protein biomarkers in a subject undergoing testing, or upon detection of changes in levels of certain protein biomarkers in conjunction with neuroimaging analyses to detect changes in vascular or blood brain barrier (BBB) permeability in the brain, or to detect damage to fiber tracts in the brain, in which changes in biomarker levels correlate with detection of changes in BBB permeability or in brain fiber tract or white matter damage in a subject with brain injury such as mTBI or concussion. | 2022-03-10 |
| 20220074954 | MEANS AND METHOD FOR THE EARLY PREDICTION OF POOR NEUROLOGICAL OUTCOME IN OUT-OF-HOSPITAL CARDIAC ARREST SURVIVORS - The present invention relates to a method for predicting the neurological outcome of a patient after cardiac arrest, the method comprising the step(s) of: (I) a) determining the level of alpha-enolase in a biological sample obtained from a patient after cardiac arrest; and b) comparing the level of alpha-enolase obtained in (a) with the median or mean level of alpha-enolase in biological samples from patients with positive neurological outcome after cardiac arrest, wherein said patient is diagnosed as having a negative neurological outcome if the alpha-enolase level is increased by at least 100% over the median or mean level of alpha-enolase, and/or a positive neurological outcome if the alpha-enolase level is below 150% as compared to the median or mean level of alpha-enolase; or (II) determining the level of alpha-enolase in a biological sample obtained from a patient after cardiac arrest, wherein said patient is diagnosed as having a negative neurological outcome if the alpha-enolase level is above 50 μg/L, and/or a positive neurological outcome if the alpha-enolase level is below 50 μg/L. | 2022-03-10 |
| 20220074955 | Method for Assessing the Effects of Hypoxia on Tissues - A method for assessing an effect of hypoxia on a tissue includes providing a sample of the tissue in a hermetically sealed container, determining a first amount of a reaction substrate(e.g., protocatechuic acid) to be introduced into the sealed container and determining a second amount of a reaction enzyme (e.g., protocatechuate dioxygenase) to be introduced into the sealed container. The method further includes introducing the reaction substrate and the reaction enzyme into the sealed container. At least one of the first amount of the reaction substrate and the second amount of the reaction enzyme is selected to induce at least one of a predetermined amount of hypoxia less than anoxia and a predetermined rate of hypoxia in the tissue during a reaction between the reaction substrate and the reaction enzyme. Values of properties of the tissue can be measured before and after the reaction to assess effects of hypoxia. | 2022-03-10 |
| 20220074956 | METHODS FOR DETERMINING THE HEMATOCRIT LEVEL IN A SAMPLE OF WHOLE BLOOD - A hematocrit level in a sample of whole blood can be determined in a lateral flow assay setting, where a sample of whole blood is applied to a substrate on which a blood spot is formed; taking an image of said blood spot within 1-300 seconds from application, subjecting said image to image analysis, and determining the hematocrit level based on a value of at least one parameter extracted from said image. Such reagent-free hematocrit measurement can be integrated in lateral flow assay devices for the measurement of an analyte and contribute to significantly improved precision of such assays. | 2022-03-10 |
| 20220074957 | METHOD FOR DETECTING THE PRESENCE AND QUANTITY OF THE LRP8 RECEPTOR AND OF ITS PROTEOLYTIC FRAGMENTS, DETECTION KIT AND RELATED ANTIBODIES - A method for detecting by means of antibodies the presence and quantity of some substrates of γ-secretase and of fragments of said substrates, obtained both by the action of said γ-secretase or of other proteases, in biological samples isolated from the human body. The invention also relates to a kit for the detection of said substrates and fragments, as well as their antibodies to be used in the method and in the kit for the diagnosis of diseases such as Alzheimer's, Down syndrome and cancers. In particular, the antibodies are produced against specific C-terminal sequences of the protein LRP8 and its fragments. | 2022-03-10 |
| 20220074958 | METHODS OF MONITORING SAFETY OF QUERCETIN COMPOSITIONS - Provided herein are methods to determine the safety of quercetin compositions regarding contaminants that can result from the degradation of quercetin, such as by storage of solid form quercetin compositions in an air atmosphere. The contaminants include protocatechuic acid, 2,4,6-trihydroxybenzoic acid, and 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoic acid. Provided herein are also methods which reduce degradation of solid form quercetin compositions and reduce the formation of such toxic compounds. The provided methods increase the shelf life and patient safety of quercetin compositions. | 2022-03-10 |
| 20220074959 | AUTOMATIC ANALYZER - A high-throughput automatic analyzer integrates a biochemical analysis section and a blood coagulation analysis section. The analyzer is capable of achieving a reduction in size, system cost, and lifecycle cost. The automatic analyzer includes: a reaction disk; a first reagent dispensing mechanism that dispenses a reagent to reaction cells on the reaction disk; a photometer that irradiates a reaction solution in the reaction cell with light; a reaction cell cleaning mechanism; a reaction vessel supply unit that supplies a disposable reaction vessel for mixing and reacting a sample and a reagent with each other; a second reagent dispensing mechanism that dispenses a reagent to the disposable reaction vessel; a blood coagulation time measuring section that irradiates a reaction solution in the disposable reaction vessel with light to detect transmitted or scattered light; and a sample dispensing mechanism that dispenses a sample to the reaction cell and the disposable reaction vessel. | 2022-03-10 |
| 20220074960 | SAMPLE PRETREATMENT DEVICE, ANALYSIS SYSTEM INCLUDING THE DEVICE, AND AUTOSAMPLER - A sample pretreatment device of an aspect of the present invention includes a conveyance mechanism ( | 2022-03-10 |
| 20220074961 | REAGENT CARTRIDGE AND AUTOMATIC ANALYZING DEVICE - A reagent cartridge according to an embodiment includes a housing part, a tubular member, and a dispense part. The housing part houses therein a reagent. The tubular member is filled with the reagent housed in the housing part. The dispense part dispenses the reagent supplied from the tubular member. The tubular member has elasticity, and supplies the reagent to the dispense part when a side face part thereof is compressed. | 2022-03-10 |
| 20220074962 | LIQUID DISPENSER WITH MANIFOLD MOUNT FOR MODULAR INDEPENDENTLY-ACTUATED PIPETTE CHANNELS - Automated pipetting systems and methods are disclosed for aspirating and dispensing fluids, particularly biological samples. In one aspect, a liquid dispenser includes a manifold and one or more pipette channels. The manifold includes a vacuum channel, a pressure channel, and a plurality of lanes. Each lane includes an electrical connector, a port to the pressure channel, and a port to the vacuum channel. The pipette channels can be modular. Each pipette channel includes a single dispense head and can be selectively and independently coupled to any one lane of the plurality of lanes. In some aspects, a valve in the pipette channel is in simultaneous fluid communication with a pressure port and a vacuum port of the manifold. The valve selectively diverts gas under pressure and gas under vacuum to the dispense head in response to control signals received through the electrical connector of the manifold. | 2022-03-10 |
| 20220074963 | A SENSOR DEVICE FOR MONITORING STRUCTURAL ELEMENTS, A CLAMPING ELEMENT, AN EXAMINATION UNIT AND A METHOD FOR CONSTRUCTING SAID SENSOR DEVICE - Sensor device ( | 2022-03-10 |
| 20220074964 | METHOD AND DEVICE FOR DETERMINING THE ROTATION FREQUENCY OF WHEELS OF VEHICLES - A device for determining the rotation frequency of at least one wheel of a vehicle provides a first measuring device for measuring an acceleration value of the at least one wheel, a second measuring means for measuring vibrations of the at least one wheel, and a processing unit configured to determine a first rotation frequency of the at least one wheel from the measured acceleration value of the at least one wheel, compare the determined first rotation frequency of the at least one wheel to a first threshold, define a frequency analysis interval from the determined first rotation frequency greater than the first threshold, process a frequency analysis of a signal indicative of vibrations of the at least one wheel for the frequencies inside the frequency analysis interval, and select a second rotation frequency in the frequency analysis interval having the higher amplitude. | 2022-03-10 |
| 20220074965 | FROTH BUBBLE MOVING SPEED MEASURING DEVICE AND METHOD OF MEASURING FROTH BUBBLE MOVING SPEED, FLOTATION APPARATUS AND FLOTATION METHOD USING SAME - A froth bubble moving speed measuring device includes a light source configured to illuminate an upper surface of a flotation tank, an imaging unit configured to capture at least a part of the upper surface of the flotation tank, and an arithmetic processing unit configured to calculate a moving speed of a froth bubble by calculating a moving distance of the froth bubble based on the image processed by the image processing unit. | 2022-03-10 |
| 20220074966 | INTEGRATED FIBER BRAGG GRATING ACCELEROMETER IN A SURGICAL INSTRUMENT - An accelerometer is included within the confined space and limited volume of a distal portion of a surgical instrument. The surgical instrument includes an end component, a joint coupled to the end component, a shaft coupled to the joint, and a force transducer and accelerometer apparatus. The force transducer and accelerometer apparatus is coupled between the joint and the shaft. The force transducer and accelerometer apparatus includes a force sensor and an accelerometer. The accelerometer includes an optic fiber having a Fiber Bragg Grating. Information acquired from the Fiber Bragg Grating is used to drive a vibrotactile haptic feedback output device coupled to a master control arm surgeon grip. | 2022-03-10 |
| 20220074967 | APPARATUS AND METHOD FOR CALIBRATING INERTIAL SENSOR - In an apparatus for calibrating an inertial sensor configured to detect an angular velocity of a vehicle, an angular velocity estimator is configured to estimate a value for an angular velocity of the vehicle based on a value for an attitude of the vehicle and a value for a change in attitude of the vehicle estimated by the attitude estimator, and an error estimator is configured to estimate a value for an angular velocity error that is an error between the value for the angular velocity of the vehicle estimated by the angular velocity estimator and the value for the angular velocity of the vehicle detected by the inertial sensor. A calibrator is configured to calibrate the value for the angular velocity of the vehicle detected by the inertial sensor based on the value for the angular velocity error estimated by the error estimator. | 2022-03-10 |
| 20220074968 | SCANNING PROBE MICROSCOPE WITH A SAMPLE HOLDER FED WITH ELECTROMAGNETIC WAVE SIGNALS - A scanning probe microscope including a holder having at least one electric port, wherein the holder is configured to support a sample to be imaged. The scanning probe microscope further includes a probe and an actuator configured to move at least one of the holder and the probe up to three directions. The scanning probe microscope further includes a reflectometer configured to measure reflection and/or transmission coefficients at each of the at least one electric ports of the holder by feeding each of the at least one electric ports of the holder with electromagnetic wave signals. | 2022-03-10 |
| 20220074969 | KELVIN CONTACT FOR INSPECTION, KELVIN SOCKET FOR INSPECTION, AND METHOD OF MANUFACTURING KELVIN CONTACT FOR INSPECTION - Provided is a Kelvin contact for inspection in which contacts and an insulating layer are less likely to be shifted relative to each other even after repeatedly performed Kelvin inspection. The Kelvin contact for inspection includes: a first contact having an upper contact point that comes into contact with one electrode terminal of an IC device and a lower contact point that comes into contact with an electrode pad of a substrate for inspection; and a second contact having an upper contact point that comes into contact with the one electrode terminal and the lower contact point that comes into contact with an electrode pad of the substrate for inspection. The first and second contacts are adjacently arranged to contact with the same one electrode terminal and provided with an insulating layer surrounding the entire main body area except upper and lower contact point areas including the upper and lower contact points, respectively. | 2022-03-10 |
| 20220074970 | PROBE ASSEMBLY - A probe assembly, adapted to test high-speed signal transmission lines of printed circuit boards, includes two pogo pins for providing high-frequency differential test signals, and both sides of the pogo pin include no metal layer (grounding layer). Experiments have found that when the two pogo pins test a to-be-tested object, the test signal will be coupled to the metal layers on both sides of the pogo pins to generate a radiation resonance, resulting in a loss of the test signal on a specific frequency band, and further reducing the effective bandwidth of the probe assembly. The metal layers on both sides of the pogo pins of the probe assembly are reduced, so that the foregoing radiation resonance phenomenon can be avoided. | 2022-03-10 |
| 20220074971 | ELECTRICAL CONNECTING DEVICE - An electrical connecting device includes an insulating probe ( | 2022-03-10 |
| 20220074972 | PROBE STATION - A probe station includes a base, a adaptor, a probe holder and a probe. The adaptor has a first portion and a second portion away from the first portion towards a first direction by a first length. The first portion connects to the base. A probe holder connects to the second portion and extends towards a second direction opposite to the first direction by a second length. The probe connects to an end of the probe holder away from the second portion and extends towards the second direction by a third length. A product of a thermal coefficient of the adaptor and the first length is equal to a sum of a product of a thermal coefficient of the probe holder and the second length and a product of a thermal coefficient of the probe and the third length. | 2022-03-10 |
| 20220074973 | CURRENT DETECTING CIRCUIT AND SWITCHING CIRCUIT - A current detecting circuit includes a first switching element, a second switching element, and a third switching element electrically coupled in series with the first switching element. An output side of the third switching element is electrically coupled to an output terminal. The current detecting circuit includes a current amplifier configured to detect a difference between a first output voltage of the first switching element and a second output voltage of the second switching element. The current amplifier outputs a relative current to be used for detecting an output current that flows out from the output terminal. A ratio of resistance associated with the first switching element to resistance associated with the second switching element is n:1. | 2022-03-10 |
| 20220074974 | CURRENT SENSOR CAPABLE OF AUTOMATIC ADJUSTMENT OF OFFSET VOLTAGE - A current sensor automatically adjusting an offset voltage, includes an input corrector, upon receiving a first voltage, a second voltage, and a control signal, configured to correct either one or both of the first voltage and the second voltage to reduce an absolute value of a difference between the first voltage and the second voltage based on the control signal, and output a correction result; an input amplifier configured to amplify a voltage output from the input corrector; an output amplifier configured to generate an output voltage when a voltage amplified by the input amplifier is input; a controller including a switch connected to one of voltages amplified by the input amplifier to be grounded when a difference between the first voltage and the second voltage is larger than a first threshold value; and a correction circuit controller configured to generate the control signal to input to the input corrector. | 2022-03-10 |
| 20220074975 | CURRENT PEAK SENSOR FOR PULSED LASER DIODE ARRAY - An apparatus and method for current peak detection. The apparatus includes a pulse laser diode array, a sense resistor, a capacitive voltage divider (CVD) electrically coupled to the pulse laser diode array, a first current rectifier, a second current rectifier, a first current peak detector, a second current peak detector, an analog-to-digital converter (ADC) operable to convert the analog outputs from each current peak detector to a digital output signal, and a digital signal processing (DSP) unit operable to detect, from the digital output signal, a current peak pulse at the top and the bottom of the sense resistor. | 2022-03-10 |
| 20220074976 | METHODS AND SYSTEMS FOR FAULT DIAGNOSIS - The present disclosure relates to a control system and methods implemented on the control system. The control system includes a tuning/detuning system and a diagnosis system. The tuning/detuning system includes a first voltage source, a second voltage source, one or more coil arrays, and one or more tuning/detuning circuit drivers corresponding to the one or more coils arrays, respectively. The diagnosis system includes a first current sampling circuit and a processor. The first current sampling circuit is configured to obtain a first current. The processor is configured to diagnose the tuning/detuning system based on the first current. | 2022-03-10 |
| 20220074977 | LOAD DETECTION SYSTEM AND LOAD DETECTION METHOD THEREOF - Provided are a load detection system and a load detection method thereof. The load detection system includes an adjustable power supply ( | 2022-03-10 |
| 20220074978 | VOLTAGE DETECTION CIRCUIT AND CHARGE PUMP CIRCUIT - A voltage detection circuit and a charge pump circuit using the voltage detection circuit are provided. The voltage detection circuit includes: a voltage raising circuit configured to adjust a voltage to be measured and then output an adjusted voltage, where the adjusted voltage is equal to the sum of the voltage to be measured and a reference voltage; and the reference voltage is generated by a combination of a first voltage with a positive temperature coefficient and a second voltage with a negative temperature coefficient. | 2022-03-10 |
| 20220074979 | MAKING DETERMINATION OF INDUCTANCE-CHANGE IMMUNE TO CHANGES IN ENVIRONMENTAL CONDITIONS - A device includes a first oscillator, a second oscillator and a frequency comparison block. The first oscillator includes a first LC tank circuit and is designed to generate first sustained oscillations at a first resonant frequency. The second oscillator includes a second LC tank circuit and is designed to generate second sustained oscillations at a second resonant frequency. The frequency comparison block is designed to perform a comparison of the frequencies of the second sustained oscillations and the first sustained oscillations to determine a change in inductance in one of a first inductor of the first LC tank circuit and a second inductor of the second LC tank circuit. One of the oscillators serves as a reference oscillator, and enables determination of the change in inductance to be immune to changes in environmental conditions. | 2022-03-10 |
| 20220074980 | AC Impedance Measurement Circuit with Calibration Function - The present invention discloses an AC impedance measurement circuit with a calibration function, which is characterized in that only one calibration impedance is needed, associated with a switch circuit. Based on the measurement results of the two calibration modes, an equivalent impedance of the switch circuit, circuit gain and phase offset can be calculated. Based on the above results, the equivalent impedance of the internal circuit is deducted from the measurement result of the measurement mode to accurately calculate an AC conductance and a phase of the AC conductance for impedance to be measured. In addition, by adjusting a phase difference between an input sine wave signal and a sampling clock signal, impedance of the same phase and impedance of the quadrature phase can be obtained, respectively, and the AC impedance and phase angle of the impedance to be measured can be calculated. | 2022-03-10 |
| 20220074981 | EXECUTION DEVICE AND EXECUTION METHOD - An execution device according to an exemplary embodiment includes an operation device, an acceleration sensor, and an arithmetic device. The operation device is a device for executing a predetermined operation. The acceleration sensor measures acceleration applied to the execution device. The arithmetic device measures an elapsed time after the acceleration measured by the acceleration sensor becomes a value within a reference range, and when a predetermined time elapses while the acceleration remains a value within the reference range, causes the operation device to execute the predetermined operation. | 2022-03-10 |
| 20220074982 | METHOD FOR IDENTIFYING EXTERNAL DEVICE BY REGISTERING FEATURES OF EM SIGNAL AND ELECTRONIC DEVICE APPLYING SAID METHOD - A method by which an electronic device interworks with an external device may be disclosed, the method comprising the operations of: obtaining an EM signal from the external device; extracting feature data by passing the obtained EM signal through a feature extraction model; receiving information related to the external device; generating registration information on the basis of the extracted feature data and the information related to the external device; and storing the generated registration information in a database of a memory, wherein the operation of receiving the information related to the external device provides an input interface for inputting information related to the external device, or shows at least one piece of pre-stored information related to the external device. In addition, other various embodiments identified through the specification are also possible. | 2022-03-10 |
