10th week of 2011 patent applcation highlights part 33 |
Patent application number | Title | Published |
20110059399 | POSITIVE-WORKING RADIATION-SENSITIVE IMAGEABLE ELEMENTS - Positive-working imageable elements having improved sensitivity, high resolution, and solvent resistance are prepared using a water-insoluble polymeric binder comprising vinyl acetal recurring units that have pendant hydroxyaryl groups, and recurring units comprising carboxylic acid aryl ester groups that are substituted with a cyclic imide group. These imageable elements can be imaged and developed to provide various types of elements including lithographic printing plates. | 2011-03-10 |
20110059400 | PHOTORESIST COMPOSITION - The present invention provides a photoresist composition comprising | 2011-03-10 |
20110059401 | METHOD FOR PREPARING LITHOGRAPHIC PRINTING PLATES - A method of preparing a lithographic printing plate including the steps of providing a lithographic printing plate precursor including a photopolymerizable coating provided on a hydrophilic support;—image-wise exposing the precursor;—pre-heating the exposed precursor;—developing the exposed precursor in a gum solution; wherein after pre-heating and before developing the precursor an accelerated cooling of the precursor is carried out and the cooling does not essentially remove a part of the coating of the precursor. | 2011-03-10 |
20110059402 | EXPOSURE METHOD - According to the embodiments, exposure is performed on a resist on a substrate at a first focus position by using a phase shift mask in which a first light transmitting area and a second light transmitting area are formed adjacently via a light shielding pattern and a phase difference between light transmitting through the first light transmitting area and light transmitting through the second light transmitting area is φ≠π, and exposure is performed on the resist at a second focus position different from the first focus position by using the phase shift mask. | 2011-03-10 |
20110059403 | METHOD OF FORMING WIRING PATTERN, METHOD OF FORMING SEMICONDUCTOR DEVICE, SEMICONDUCTOR DEVICE, AND DATA PROCESSING SYSTEM - A method of forming a pattern includes the following processes. A first lithography process is performed. The first lithography process is applied to a first region of a substrate. A second lithography process is performed. The second lithography process is applied to the first region and to a second region of the substrate, to form a first pattern in the first region, and to form a second pattern in the second region. The first pattern is defined by a first dimension. The first dimension is smaller than a resolution limit of lithography. The second pattern is defined by a second dimension. The second dimension is equal to or greater than the resolution limit of lithography. | 2011-03-10 |
20110059404 | RESIST UNDERLAYER FILM FORMING COMPOSITION AND FORMING METHOD OF RESIST PATTERN USING THE SAME - It is an object to provide a resist underlayer film forming composition having a large selection ratio of a dry etching rate, and having a k value and an n value at a short wavelength such as an ArF excimer laser, both of which exhibit desired values. There is provided a resist underlayer film forming composition containing a polymer obtained by reacting at least a tetracarboxylic dianhydride having an alicyclic structure or an aliphatic structure and a diepoxy compound having two epoxy groups with an organic solvent containing an alcohol-based compound having an OH group, and a solvent. | 2011-03-10 |
20110059405 | SUBSTRATE PROCESSING METHOD - A substrate processing method, includes: forming a resist film above a substrate; exposing the resist film; developing the resist film using a developing fluid after the exposing of the resist film; cleaning the resist film using a rinsing fluid after the developing of the resist film; and drying the resist film in a processing chamber after the cleaning of the resist film, inside the processing chamber being an atmosphere including an ion, the atmosphere including the ion being caused by introducing a gas including the ion produced externally to the processing chamber into the processing chamber. | 2011-03-10 |
20110059406 | PATTERN FORMING METHOD - According to one embodiment, a pattern forming method is disclosed. The method can include selectively providing a curing agent to a pattern in a template, contacting the template provided the curing agent to a substrate, irradiating the curing agent with light where the template and the substrate are contacted each other to harden the curing agent, demolding the template from the substrate to form a curing agent pattern on the substrate, and etching the substrate on a basis of the curing agent pattern. | 2011-03-10 |
20110059407 | DOUBLE PATTERNING STRATEGY FOR FORMING FINE PATTERNS IN PHOTOLITHOGRAPHY - A method of lithography patterning includes forming a first resist pattern over a substrate, baking the first resist features, hardening the first resist features, forming a second resist layer within the hardened first resist features, and patterning the second resist layer to form at least one second resist feature between the hardened first features. | 2011-03-10 |
20110059408 | METHOD AND BURNER ARRANGEMENT FOR THE PRODUCTION OF HOT GAS, AND USE OF SAID METHOD - A method for producing hot gas for operating a turbomachine fired with at least one combustion chamber includes premixing a fuel with a plurality of operating gases by introducing fuel into the plurality of operating gases in a mixing chamber disposed upstream of the combustion chamber using a burner arrangement, wherein the fuel includes at least one of a combustible gas and a H | 2011-03-10 |
20110059409 | Liquid Fuel Vaporizer and Combustion Chamber Having an Adjustable Thermal Conductor - The efficiency and effectiveness of apparatuses for vaporizing and combusting liquid fuel can be improved using thermal conductors. For example, an apparatus having a liquid fuel vaporizer and a combustion chamber can be characterized by a thermal conductor that conducts heat from the combustion chamber to the vaporizer. The thermal conductor can be a movable member positioned at an insertion depth within the combustion chamber that corresponds to a rate of heat conduction from the combustion chamber to the vaporizer. The rate of heat conduction can, therefore, be adjusted by positioning the movable member at a different insertion depth. | 2011-03-10 |
20110059410 | COMBUSTION APPARATUS - Provided is a combustion apparatus ( | 2011-03-10 |
20110059411 | METHOD FOR HEATING LIQUID HEAT CARRIER AND A DEVICE FOR CARRYING OUT SAID METHOD - The proposed heating method includes supplying a liquid heat carrier to a heating area by means of turning it about the cylindrical surface of a heater in such a way as to form an axially symmetric swirl flow, the trajectory of each heat carrier particle being tangent to the surface of the heater the temperature of which is higher than the critical thermal point of the heat carrier. The heating device contains a heat exchanger having a cylindrical body, tangentially positioned pipes for supplying the cold heat carrier and pipes for discharging the hot heat carrier. The heater having a cylindrical surface is coaxially arranged in the cylindrical body. The heating device contains an expansion tank, binding pipes and heat exchangers. The temperature of the heater is controlled by means of thermocouples. An electric heat source (a resistance helix) is located in the heater. The heating device has a high efficiency of heat transfer from the heater to the heat carrier due to the double phase transition: water-steam-water. | 2011-03-10 |
20110059412 | DEVICE AND PROCESS FOR ERADICATING PESTS IN WOOD - A device and process for heating wood for the purpose of eradicating burrowed pests such as gypsy moths and emerald ash borer beetles are disclosed. The device is used for treating firewood and pallets made of wood to insure that burrowed pests are killed before transporting the wood across state lines in following of state regulations. The device comprises a conveyor adapted for transporting firewood or pallets an insulated and heated chamber. The wood core temperature of the wood is monitored using wireless temperature sensors. Conveyor speed is adjusted according to temperature readings in order to achieve a threshold wood core temperature and in order to maintain the threshold wood core temperature for the minimum required period of time. | 2011-03-10 |
20110059413 | METHOD FOR DERIVING SHAPE INFORMATION - A method for deriving shape information of a person's skull and dentition, comprising the steps of: taking an impression of the person's dentition, taking a first scan of the person's head, while the person is wearing the impression, taking a second scan of the impression alone, combining the scans, deriving the shape information from the combined scans. Advantageously the method further comprises the step of taking a third scan of the person's head alone without the impression. | 2011-03-10 |
20110059414 | ORTHODONTIC BRACKET - The invention relates to an orthodontic component ( | 2011-03-10 |
20110059415 | Method and device for laser machining biological tissue - A method of laser machining biological tissue including the provision of a pulsed processing laser beam and the processing of tissue by radiation using the pulsed processing laser beam, wherein the processing laser beam has a wavelength of the laser pulses ranging between 700 nm and 1400 nm, a time duration of the laser pulses ranging between 5 ps and 100 ps, and an energy density of the laser pulses on the surface of the tissue ranging between 1.5 J/cm | 2011-03-10 |
20110059416 | ASSISTANT APPARATUS FOR ORAL TREATMENT AND UNIT CHAIR WITH THE SAME - Provided is an assistant apparatus for oral treatment including dental treatment and a unit chair equipped with the same. The assistant apparatus includes an oral cavity insertion member positioned in the oral cavity in front of the uvula of a patient, or preferably, on the soft palate, such that washing liquid or saliva is prevented from entering a patient's throat during oral treatment. Therefore, it is possible to prevent patient discomfort and interruption of treatment. Further, medical instruments/components are prevented from entering the throat and injuring the pharynx. | 2011-03-10 |
20110059417 | FLUID AND PULSED ENERGY OUTPUT SYSTEM - A fluid conditioning system is adapted to condition the fluid used in medical and dental cutting, irrigating, evacuating, cleaning, and drilling operations. The fluid may be conditioned by adding flavors, antiseptics and/or tooth whitening agents such as peroxide, medications, and pigments. In addition to the direct benefits obtained from introduction of these agents, the laser cutting properties may be varied from the selective introduction of the various agents. | 2011-03-10 |
20110059418 | HIGH SPEED BALL BEARING FOR DENTAL OR MEDICAL HANDPIECES - A bearing assembly ( | 2011-03-10 |
20110059419 | GINGIVA INCISING DEVICE - To easily incise a gingiva particularly at a tongue side and a lip side of a jawbone formed as a bank shape, a gingiva incising device has a cylinder portion, which is longer than a thickness of a gingiva and has approximately the same diameter as a diameter of a dental implant fixture, at a leading end side of a main body portion having a grip portion at a rear end side, and has a cutting blade portion for incising the gingiva formed on a whole periphery of the leading end of the cylinder portion, and the cutting blade portion has a portion which protrudes gradually from a position closest to the grip portion toward a position away from the grip portion. | 2011-03-10 |
20110059420 | Dental Prophylactic Paste - A dental prophylactic paste having excellent flowability during the manufacturing process, minimal to no splattering during use, and remineralization characteristics is provided. The prophylactic paste includes at least one water soluble calcium salt; a water soluble phosphate salt, a water soluble silicate; and a moisture retention agent. The paste has a splatter rating of less than 3. The splatter rating of the paste refers to the tendency of the paste to splatter during a dental cleaning procedure. The lower the splatter rating, the less the paste has a tendency to splatter. A paste having a splatter rating of less than 3 is considered to have good handability. | 2011-03-10 |
20110059421 | APPARATUS AND METHOD FOR AUTOMATED FEEDBACK AND DYNAMIC CORRECTION OF A WEAPON SYSTEM - A method, apparatus, and system for adjusting a targeting solution of a weapon system are provided. The weapon system may fire a projectile at a target, where the projectile comprises a location device. The location device may be active or passive. A location notification is received about the first projectile. An impact location of the projectile is determined based on the location notification. The targeting solution of the weapon system is adjusted based on the determined first impact location. The targeting solution may be adjusted directly or indirectly. An indirect adjustment of the targeting solution may include displaying a projectile-status display and/or providing a suggested targeting solution. | 2011-03-10 |
20110059422 | Physiological and cognitive feedback device, system, and method for evaluating a response of a user in an interactive language learning advertisement - An embodiment is a physiological and cognitive feedback device, system, and method for evaluating a response of a user in an interactive language learning advertisement. Foreign language lessons are provided at no cost to consumers online in exchange for the consumers' feedback on the products or services embedded in the language lessons. The language lessons may use television advertisements as course material, serving both educational and promotional purposes. Revenues are generated through product placement opportunities as well as consumer survey responses that are a part of the lessons. | 2011-03-10 |
20110059423 | SYSTEM AND METHOD FOR PROVIDING SCALABLE EDUCATIONAL CONTENT - Presented are a system and method for providing a graphical user interface (GUI) based modular platform having educational content. The method includes providing an interactive GUI on a computing device accessible by a user, receiving a first indication of a language being studied, displaying a GUI layer presenting a selection of level, unit, activity, and/or lesson, receiving a lesson selection, and computing a rating or score of the user's performance for the lesson. The system includes a control module, a language parser accessing content within repositories and providing language specific content, a syntax rule base providing language specific rules to the language parser, a lesson format base providing a lesson style to the control module, and a speech recognition system evaluating a user's utterance for pronunciation and sentence structure accuracy. | 2011-03-10 |
20110059424 | Visual Mathematical Learning Device - A visual mathematical learning aid of numbers and their increasing values as they increase from left to right and from bottom to upward direction through the use of a container with lid for vertically maintaining a plurality of calibrated rods representing the units 1-10 in ascending order from right to left. | 2011-03-10 |
20110059425 | APPARATUS AND METHODS FOR VISUAL DEMONSTRATION OF DENTAL EROSION ON SIMULATED DENTAL MATERIALS - Comparative effectiveness of various oral care products such as dentifrices on preventing dental erosion may be demonstrated using simulated enamel. A substrate is prepared. A mineral layer to simulate dental enamel is nucleated by solution growth on the substrate surface. Alternatively, the mineral layer may be nucleated on a template comprising a self-assembled monolayer formed on a gold layer deposited on the substrate surface. The mineral layer may comprise a homogeneous layer of hydroxyapatite or a thin veneer of hydroxyapatite on a layer of amorphous calcium phosphate. The simulated enamel is then optionally treated with an oral care product and subjected to an acid challenge. The amount of mineral layer remaining after the acid challenge illustrates the effectiveness or non-effectiveness of the oral care product at preventing dental erosion. | 2011-03-10 |
20110059426 | Book - A book for displaying images and playing associated audio content. The book comprises a plurality of leaves defining pages of the book. A plurality of pairs of transmitters and receivers are arranged on the leaves, so that a plurality of the leaves each has a transmitter and a plurality of the leaves each has a receiver. Capacitance coupling between a transmitter and its paired receiver depends upon whether a page of the book is open. The book has a controller configured to provide pulsed signals to the transmitters and receive signals from the receivers. In addition the book has memory for audio content and an audio playback device. The controller is configured to identify any open page of the book by comparing signals received by the receivers from the transmitters to a threshold value. If only one page is open, the controller identifies associated audio content relevant to the open page from audio stored in the memory and identified audio is played on the audio playback device. | 2011-03-10 |
20110059427 | Method for the computer-assisted learning of a control and/or a feedback control of a technical system - A method of computer-assisted learning of control and/or feedback control of a technical system is provided. A statistical uncertainty of training data used during learning is suitably taken into account when learning control of the technical system. The statistical uncertainty of a quality function, which models an optimal operation of the technical system, is determined by uncertainty propagation and is incorporated during learning of an action-selecting rule. The uncertainty propagation uses a covariance matrix in which non-diagonal elements are ignored. The method can be used for learning control or feedback control of any desired technical systems. In a variant, the method is used for control or feedback control of an operation of a gas turbine. In another variant, the method is used for control or feedback control of a wind power plant. | 2011-03-10 |
20110059428 | MEMORIZATION SYSTEM - A memorization system includes a housing having an open end to form a hollow chamber. A first compartment having an open end is disposed within the housing. A second compartment also is provided having a first aperture and at least one card is slidably and removably received within the second compartment. The card includes first and second columns of printed indicia wherein information in the first column is related and corresponds to information in the second column. In addition, the information in the second column of printed indicia represents information to be memorized. | 2011-03-10 |
20110059429 | Apparatus and method for maintaining and/or restoring viability of organs - An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program. | 2011-03-10 |
20110059430 | CROSS-SPOT - The invention relates to an in vitro method for measuring the presence of an antigen indicative for the presence of an infectious agent, and preferably a medical condition or disease in a sample using an immune effector cell capable of producing an immune effector molecule following stimulation by an antigen. | 2011-03-10 |
20110059431 | NON-ENZYMATIC DETECTION OF BACTERIAL GENOMIC DNA - The present invention relates to methods for detecting for the presence of one or more target analytes, e.g. biomolecules, in a sample. In particular, the present invention relates to a method that utilizes blocking strands to inhibit target rehybridization to detect double stranded genomic DNA. | 2011-03-10 |
20110059432 | METHOD FOR PROVIDING DNA FRAGMENTS DERIVED FROM A REMOTE SAMPLE - Aspects of the present invention relate to compositions and methods for providing DNA fragments from a remote sample. In particular aspects a remote sample comprising DNA is provided, DNA is isolated from the remote sample, and the isolated DNA is treated in a way which allows differentiation of methylated and unmethylated cytosine. Additional, particular embodiments provide compositions and methods for methylation analysis of DNA derived from a remote sample. Other aspects provide for compositions and methods of whole genome amplification of bisulfite treated DNA. | 2011-03-10 |
20110059433 | Method for the detection and characterization of microorganisms on a filter - The present invention relates to a method for the specific detection on a filter of one or more microorganisms present in a fluid, characterized in that it comprises the following steps: a) contacting the microorganisms present in the fluid or on the surface with the filter; b) amplifying specifically the nucleic acids from the microorganism or microorganisms present on the filter, in an isothermal manner, in order to obtain amplification products, c) detecting the amplification products. The invention also relates to a device, a kit and oligonucleotides suitable for the implementation of this method. | 2011-03-10 |
20110059434 | P13k pathway mutations in cancer - Given the important role of protein kinases in pathways affecting cellular growth and invasion, we have analyzed 340 serine/threonine kinases for genetic mutations in colorectal cancers. Mutations in eight genes were identified, including three members of the phosphatidylinositol-3-kinase (PI3K) pathway; the alterations in the latter genes each occurred in different tumors and did not overlap with mutations in PIK3CA or other non-serine-threonine kinase (STK) members of the PI3K pathway, suggesting that mutations in any of these genes had equivalent tumorigenic effects. These data demonstrate that the PI3K pathway is a major target for mutational activation in colorectal cancers and provide new opportunities for therapeutic intervention. | 2011-03-10 |
20110059435 | Methods for Beaming - Improvements on the basic method used for BEAMing increase sensitivity and increase the signal-to-noise ratio. The improvements have permitted the determination of intrinsic error rates of various DNA polymerases and have permitted the detection of rare and subtle mutations in DNA isolated from plasma of cancer patients. | 2011-03-10 |
20110059436 | METHODS FOR SEQUENCE DETERMINATION - A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system. | 2011-03-10 |
20110059437 | PCR-BASED GENOTYPING | 2011-03-10 |
20110059438 | Method of Preparing DNA Fragments and Applications Thereof - A method of preparing DNA fragments, which entails at least the following steps of:
| 2011-03-10 |
20110059439 | COMPOSITION AND METHOD FOR IMAGING STEM CELLS - An expression vector, comprising a first reporter nucleic acid sequence operably linked to a first expression control sequence comprising a promoter; and a second reporter nucleic acid sequence operably linked to a second expression control sequence that comprises a response element that is activated or inactivated as one or more of the cells differentiate or dedifferentiate. Methods and kits for imaging and monitoring stem cells comprising the expression vector are also provided. | 2011-03-10 |
20110059440 | RAPID ANALYSIS OF VARIATIONS IN A GENOME - The invention provides a method useful for determining the sequence of large numbers of loci of interest on a single or multiple chromosomes. The method utilizes an oligonucleotide primer that contains a recognition site for a restriction enzyme such that digestion with the restriction enzyme generates a 5′ overhang containing the locus of interest. The 5′ overhang is used as a template to incorporate nucleotides, which can be detected. The method is especially amenable to the analysis of large numbers of sequences, such as single nucleotide polymorphisms, from one sample of nucleic acid. | 2011-03-10 |
20110059441 | METHOF OF PRODUCING BIOACTIVE PAPER - The present disclosure relates to methods for attaching bioactive agents to paper products by contacting the paper with a solution comprising colloidal support particles where said colloidal support particles are associated with bioactive agents. In specific embodiment of the disclosure, the colloidal support particles are functionalized poly(N-isopropylacrylamide) microgels. The disclosure further covers the bioactive paper produced by this method as well as uses thereof, in particular for pathogen detection. | 2011-03-10 |
20110059442 | Multiplex detection of nucleic acids - Methods of detecting nucleic acids, including methods of detecting two or more nucleic acids in multiplex branched-chain DNA assays, are provided. Nucleic acids captured on a solid support are detected, for example, through cooperative hybridization events that result in specific association of a label with the nucleic acids. Compositions, kits, and systems related to the methods are also described. | 2011-03-10 |
20110059443 | FLUORESCENT GFP VARIANT DISPLAYING HIGHLY INCREASED FLUORESCENCE INTENSITY WITHOUT A SPECTRAL SHIFT - The present invention relates to a nucleic acid molecule encoding a polypeptide having a fluorescence emission activity with a maximum emission at 505 to 515 nm, wherein said nucleic acid molecule is selected from the group consisting of (a) a nucleic acid molecule encoding a polypeptide having the amino acid sequence of SEQ ID NO: 2; (b) a nucleic acid molecule having the DNA sequence of SEQ ID NO: 1; (c) a nucleic acid molecule hybridizing under stringent conditions to the complementary strand of (i.) a nucleic acid molecule of (a), wherein said nucleic acid molecule of (c) encodes a polypeptide having at the position corresponding to position 146 of SEQ NO:2 a phenylalanine and at the position corresponding to position 203 of SEQ NO:2 a threonine; or (ii) a nucleic acid molecule of (b), wherein said nucleic acid molecule of (c) has at the positions corresponding to positions 438 to 440 of SEQ ID NO: 1 a nucleotide triplet selected from the group consisting of TTT and TTC; and at the positions corresponding to positions 609 to 611 of SEQ ID NO: 1 a nucleotide triplet selected from the group consisting of ACT, ACC, ACA, ACG; wherein the polypeptide encoded by the nucleic acid molecule of (c) has a fluorescence enhanced by at least the factor of 2.5 as compared to the polypeptide having the amino acid sequence of SEQ ID NO: 10; or (d) a nucleic acid molecule degenerate with respect to the nucleic acid molecule of (b). The present invention furthermore relates to a polypeptide encoded by the nucleic acid molecule of the invention, a vector and a host cell comprising the nucleic acid molecule of the invention, a method of producing said polypeptide, a fusion protein comprising the polypeptide of the invention and methods of detecting the presence and/or localization of a protein of interest and methods of detecting the activity of a promoter. | 2011-03-10 |
20110059444 | Magnetic Detection of Small Entities - A novel detection or quantifying method for biological entities or molecules such as, but not limited to, DNA, microorganisms and pathogens, proteins and antibodies, that by themselves are target molecules or from which target molecules are extracted, comprises the steps of i) forming target molecule-dependent volume-amplified entities, ii) allowing magnetic nanoparticles to bind to said volume-amplified entities, and iii) measuring changes in dynamic magnetic response of the magnetic nanoparticles caused by the increase in hydrodynamic volume of said magnetic nanoparticles or measuring the magnetic field due to the magnetic nanoparticles as they bind to a sensor surface functionalized with a secondary capturing probe. Biosensors and kits are adapted to be used in such a method. | 2011-03-10 |
20110059445 | MUCOSAL GENE SIGNATURES - Infliximab (IFX) is an effective treatment for Crohn's disease (CD) and ulcerative colitis (UC) not responding to standard therapy. Thirty percent to forty percent of patients however do not improve and the response is often incomplete. We identified mucosal gene signatures predictive of response to EFX using high-density oligonucleotide arrays. Eight UC patients and twelve CD patients showed healing. In UC, only one probe set was differentially expressed in responders compared with non-responders, i.e., IL-13R(alpha)2. At PAM analysis, two probe sets, representing IL-13Ralpha2 and IL-I 1, separated IBD responders from non-responders with an overall misclassification error rate of 0.046 (2/43), with 100% sensitivity and 91.3% specificity. The IL-13R(alpha)2 probe set was a top-ranked probe set in all our analyses using both LIMMA and PAM strategies. Our gene array studies of mucosal biopsies identified IL-13R(alpha)2 in IBD as a predictor of response or non-response to IFX. | 2011-03-10 |
20110059446 | METHOD FOR DETERMINING METHYLATION AT CYTOSINE RESIDUES - The present invention refers to a method and reagent kits for determining methylation at cytosine (dC) residues in nucleic acids, such as DNA. | 2011-03-10 |
20110059447 | METHOD FOR THE DETECTION OF GENE TRANSCRIPTS IN BLOOD AND USES THEREOF - The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-associated genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen. | 2011-03-10 |
20110059448 | COMPOSITIONS AND METHODS FOR DETERMINING CANCER STEM CELL SELF-RENEWAL POTENTIAL - In alternative embodiments, the invention provides compositions and methods for determining the self-renewal potential of a cancer stem cell (CSC) through analysis of the cross-talk between cell self-renewal pathways leading to deregulation and enhanced self-renewal of the CSC, or for predicting the drugability (susceptibility to a drug) of a CSC, and/or for predicting the progression of a cancer that corresponds to the CSC, the method comprising detecting and quantifying in CSCs one or more B-cell lymphoma-2 (Bcl-2) family protein isoform(s) or transcripts (mRNAs, messages) encoding one or more Bcl-2 family protein(s) or protein isoform(s) thereof. In alternative embodiments, the invention provides compositions and methods to determine and measure the levels of Wnt, glycogen synthase kinase-3 beta (GSK-3 beta), glycogen synthase kinase-3 alpha (GSK-3 alpha), and/or Sonic Hedgehog Homolog (SHH or Shh) family proteins and alternatively spliced transcripts (mRNAs), and Wnt, GSK3beta, GSK3alpha and/or Shh family protein and alternatively spliced transcript ratios in cancer cells, e.g., stem cells, e.g., CSCs, for diagnostic, drug discovery and prognostic purposes. | 2011-03-10 |
20110059449 | METHODS AND COMPOSITIONS FOR DIAGNOSING AND MONITORING TRANSPLANT REJECTION - Methods of diagnosing or monitoring transplant rejection or cytomegalovirus infection in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection or cytomegalovirus infection and kits or systems containing the same are also described. | 2011-03-10 |
20110059450 | LABELED NUCLEOTIDE ANALOGS AND USES THEREFOR - Labeled nucleotide analogs used in place of naturally occurring nucleoside triphosphates or other analogs in template directed nucleic acid synthesis reactions and other nucleic acid reactions, and various analyses based thereon, including DNA sequencing, single base identification, hybridization assays and others. | 2011-03-10 |
20110059451 | DETECTING FETAL CHROMOSOMAL ABNORMALITIES USING TANDEM SINGLE NUCLEOTIDE POLYMORPHISMS - The invention provides tandem single nucleotide polymorphisms and methods for their use, for example, in diagnosing Down Syndrome. | 2011-03-10 |
20110059452 | METHODS OF SCREENING FOR GASTRIC CANCER - Method and systems are provided for diagnosing or monitoring a gastric cancer in a subject. Such methods include providing a biological sample from the subject; determining an amount in the sample of at least one biomarker, selected from the group consisting of: CDH17 and OLFM4; and comparing the amount of the at least one biomarker in the sample, if present, to a control level of the at least one biomarker. Such systems include a probe for selectively binding each of at least one biomarker. | 2011-03-10 |
20110059453 | Poly(A) Tail Length Measurement by PCR - Methods and kits for measuring the length of the poly(A) tail of selected target mRNA are disclosed herein. In preferred aspects the mRNA population is modified by addition of a tail comprising guanosine and inosine (G/I tailing). The added tail is used as a priming site for reverse transcription. The resulting cDNA is then amplified using one or more target specific primers and a universal primer that recognizes the tailed region. The products are separated according to size and the size is used to estimate the polyA tail length. | 2011-03-10 |
20110059454 | FLUORESCENCE ENERGY TRANSFER BY COMPETITIVE HYBRIDIZATION - A method is provided for detecting the presence of nucleotides or monitoring nucleotide amplification. It utilizes fluorescence energy transfer by competitive hybridization. Competitive hybridization is achieved by using unequal length complementary probes which have a fluorophore on one probe and a quencher on the other. The fluorophore and quencher are juxtaposed in a manner wherein the proximity of the quencher to the fluorophore produces quenching of the fluorescence of the fluorophore. | 2011-03-10 |
20110059455 | METHODS AND COMPOSITIONS FOR DIRECT CHEMICAL LYSIS - A direct chemical lysis composition includes an assay compatible buffer composition and an assay compatible surfactant. When combined with a specimen storage composition, such compositions prevent undesired modifications to nucleic acid and proteins lysed from cells in the biological sample. Assays of samples from such compositions do not require expensive and time-consuming steps such as centrifugation and prolonged high temperature processing. The direct chemical lysis composition of the present invention permits direct nucleic acid extraction from the cells in the biological sample without the need to decant off the transport media or otherwise exchange the transport media with assay compatible buffers. There is no need to combine the sample with proteinase K or another enzyme to extract nucleic acids from the cells. A method for lysing cells to obtain target nucleic acid for assay and a kit for combining the direct chemical lysis composition with a sample are also contemplated. | 2011-03-10 |
20110059456 | System for the Cell-Specific and Development-Specific Selection of Differentiating Embryonic Stem Cells, Adult Stem Cells and Embryonic Germline Cells - The invention relates to a system for selecting differentiating embryonic or adult stem cells or embryonic germline cells in a cell-specific and development-specific manner, using a combination of resistance genes and detectable reporter genes under the common control of a cell-specific and/or development-specific promoter. | 2011-03-10 |
20110059457 | SELECTIVE RESTRICTION FRAGMENT AMPLIFICATION: FINGERPRINTING - The invention relates to a process for the controlled amplification of at least one part of a starting DNA containing a plurality of restriction sites for a determined specific restriction endonuclease, and of which at least part of its nucleic acid is unknown. This technology can be applied to human, animal or plant DNA fingerprinting, to identify restriction fragment length polymorphisms. Also encompassed by the inventive technology are kits for the application of the process. | 2011-03-10 |
20110059458 | COMPOSITIONS AND METHODS FOR CATALYZING DNA-PROGRAMMED CHEMISTRY - The present invention relates compositions and methods that are useful in catalyzing DNA-Programmed Chemistry (or Nucleic Acid-templated chemistry) for use in therapeutic and diagnostic applications. | 2011-03-10 |
20110059459 | BRCA1 mRNA EXPRESSION PREDICTS SURVIVAL IN PATIENTS WITH BLADDER CANCER TREATED WITH NEOADJUVANT CISPLATIN-BASED CHEMOTHERAPY - The invention relates to methods for predicting the clinical outcome of a patient which suffers from bladder cancer based on the expression levels of BRCA1 wherein high BRCA1 expression levels are indicative of a poor prognosis. Moreover, the invention relates to methods for predicting the response to chemotherapy of a patient which suffers from bladder cancer based on the expression levels of BRCA1, in particular, in patients which have been treated with chemotherapy prior to surgical removal of the tumor. | 2011-03-10 |
20110059460 | Infection Mediated Foam Dissolution Rate Measurement - The subject invention concerns methods and materials for determining the presence or absence of bacterial or fungal infection in a blood sample. In one embodiment, a method of the invention comprises exposing an anticoagulant treated blood sample to freezing the sample to a solid, followed by thawing of the sample and then agitation of the sample to develop foam and then observing the rate that foam dissolves. | 2011-03-10 |
20110059461 | METHODS OF DIAGNOSING MYELODYSPLASTIC SYNDROME (MDS) OR LEUKEMIA USING NUCLEIC ACIDS OR FRAGMENTS ENCODING FLT3 KINASE - To provide a nucleic acid encoding a receptor protein kinase, wherein the nucleic acid has tandem duplication in a nucleotide sequence of a juxtamembrane and is useful for diagnosis of leukemia; a polypeptide encoded by the nucleic acid; an antibody capable of specifically binding to a region encoded by the nucleic acid having tandem duplication occurring in a nucleotide sequence of a juxtamembrane; a nucleic acid capable of specifically binding to the nucleic acid having tandem duplication occurring in a nucleotide sequence of a juxtamembrane; a method for detection of the nucleic acid encoding a receptor protein kinase; and a kit therefor. A nucleic acid encoding a receptor protein kinase, wherein the nucleic acid has tandem duplication in a nucleotide sequence of a juxtamembrane; a polypeptide encoded by the nucleic acid; an antibody capable of specifically binding to the portion of the polypeptide; a nucleic acid capable of specifically binding to the nucleic acid; a method for detection of the nucleic acid; and a kit for detection. | 2011-03-10 |
20110059462 | AUTOMATED PARTICULATE CONCENTRATION SYSTEM - An automated system for concentrating potentially harmful substances from various water types or other non-viscous liquids to facilitate detection of those substances is disclosed herein. The automated system comprises a water pressure driven or pump driven concentration unit that filters the test fluid through a hollow-fiber filter. Material collected on the filter is backflushed into a collection vessel by passing a small volume of sterile solution through the filter in the reverse direction. The automated system can be configured to be portable or to be integrated into a continuous liquid stream for online monitoring of test fluids. Optionally, an electronic signal at the end of the backflush sequence triggers a detector, such as an automated array biosensor, to begin processing and analyzing the sample. | 2011-03-10 |
20110059463 | Serine and Threonine Phosphorylation Sites - The invention discloses 726 novel phosphorylation sites identified in carcinoma and leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies that specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above. | 2011-03-10 |
20110059464 | Biomarker Panel For Prediction Of Recurrent Colorectal Cancer - The present invention provides a biomarker panel predictive of whether colorectal cancer is likely to recur or metastasize in an afflicted patient. By identifying the likelihood of recurrence, a treatment provider may determine in advance those patients who would benefit from certain types of treatment. The present invention further provide methods of identifying gene and protein expression profiles associated with the likelihood of recurrence/metastasis of colorectal cancer in a patient sample. | 2011-03-10 |
20110059465 | SCREENING ASSAYS FOR AGENTS THAT ALTER INHIBITOR OF APOPTOSIS (IAP) PROTEIN REGULATION OF CASPASE ACTIVITY - The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases, for example, an interaction of the X chromosome linked IAP (XIAP) and caspase-3, caspase-7 or caspase-9, wherein the IAP regulates the activity of the caspases. The invention provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a caspase such as caspase-3 or caspase-7. The invention also provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a pro-caspase such as pro-caspase-9. In addition, the invention also provides methods for identifying agents that modulate the activity of a caspase in the presence of an IAP and that regulate the activation of a pro-caspase by an IAP. The invention further provides methods of reducing the severity of a pathologic condition in an individual by administering to the individual an agent that alters the caspase inhibitory activity of an IAP. In addition, the invention provides methods of modulating the ability of a population of cells to survive ex vivo by contacting the cells with an agent that alters the caspase inhibitory activity of an IAP in the cells. | 2011-03-10 |
20110059466 | SUPPORT FOR ELECTROPHORESIS INCLUDING HYDROPHOBIC POLYMER MEMBRANE, AND ELECTROPHORETIC SEPARATION METHOD USING THE SAME - There is provided a membrane electrophoresis which renders possible glycan analysis of polysaccharide and glycoprotein by separating protein, glycoprotein or polysaccharide by electrophoresis, followed by carrying out a glycan-releasing treatment of the membrane used in the electrophoresis, or a membrane electrophoresis which renders possible detection of the same by an immunostaining which uses an antibody, wherein a layer containing a hydrophilic polymer is formed on a hydrophobic polymer membrane by coating the hydrophilic polymer on the whole surface of the hydrophobic polymer membrane or by soaking the hydrophobic polymer membrane in a solution of the hydrophilic polymer, which is used as a substrate for electrophoresis. | 2011-03-10 |
20110059467 | CONTROLLED MODIFICATION OF SEMICONDUCTOR NANOCRYSTALS - A controlled valency semiconductor nanocrystal can have a desired number of compounds associated with it. The semiconductor nanocrystal can have exactly one compound associated with it, and the compound can have exactly one binding site for an affinity target. The semiconductor nanocrystal can be used to image single copies of cell-surface proteins. | 2011-03-10 |
20110059468 | Magnetic separation device for cell sorting and analysis - A magnetic sifter is adapted for manipulation of biological cells by providing a greater pore density at the edge of the sifter than at the center. Application of an external magnetic field to the sifter causes high magnetic fields and field gradients at the sifter pores. These conditions are suitable for capturing magnetically tagged or labeled cells at the sifter pores. Altering the external magnetic field can provide controlled capture and/or release of magnetically labeled cells from the sifter pores. The purpose of having a greater pore density at the periphery of the sifter than at the center is to provide improved flow rate uniformity through the sifter. Such flow rate uniformity is advantageous for cell quantification. | 2011-03-10 |
20110059469 | ANTI-CLDN6 ANTIBODY - The present invention relates to an antibody binding to Claudin6 (CLDN6) expressed on a cell membrane. The antibody of the present invention recognizes human CLDN6 present in a native form on cell membrane surface and exhibits cytotoxicity through ADCC and/or CDC activities against cancer cell lines highly expressing human CLDN6. Moreover, the antibody of the present invention has cell growth inhibitory effect through conjugation with toxin on cancer cell lines highly expressing human CLDN6. The human CLDN6 is overexpressed in tumor tissues (lung adenocarcinoma, gastric cancer, and ovarian cancer), although its expression is not observed in normal tissues. Thus, the anti-CLDN6 antibody is expected to highly accumulate in tumors highly expressing human CLDN6 and can serve as a very effective antitumor agent. | 2011-03-10 |
20110059470 | Tumor Microenvironment of metastasis (TMEM) and uses thereof in diagnosis, prognosis and treatment of tumors - Disclosed are methods for determining the risk of tumor cells undergoing metastasis, for assessing the prognosis of a subject undergoing treatment for a localized tumor, and for determining a course of treatment for a localized tumor comprising detecting the presence of an endothelial cell, a macrophage, and an invasive tumor cell in direct apposition in a tumor sample from a subject. | 2011-03-10 |
20110059471 | ANTIBODY HAVING AN IMMUNE-ENHANCEMENT FUNCTION - The present invention provides a monoclonal antibody against FLJ32028, which binds specifically to the surfaces of regulatory T-cells (Treg) and especially to the surfaces of induced Treg. This monoclonal antibody can be used for a Treg-removal method or a Treg-removal apparatus. This monoclonal antibody can also be used as a drug that improves cell-proliferation function, an immune-enhancement function, or especially for cancer treatment. | 2011-03-10 |
20110059472 | REAGENTS AND METHODS FOR DETECTING INFLUENZA VIRUS PROTEINS - Antibodies that specifically bind to a peptide having an amino acid sequence as found at the N-terminus of the HA2 fusion peptide of the influenza A virus may be raised by inoculating a mammal with a conjugate of the peptide. In one embodiment, the conjugate comprises the peptide linked to a spacer (e.g. 6-aminocaproic acid) and a carrier protein (e.g. KLH). The antibodies may be used as a universal reagent for detecting HA proteins of influenza viruses. The antibodies are useful as versatile reagents for laboratory research and vaccine potency determination, especially in the event of pandemic influenza outbreaks. | 2011-03-10 |
20110059473 | PROTEINS WITH PTERIDINE GLYCOSYLTRANSFERASE ACTIVITY AND ANALYSIS METHOD USING THE SAME - The present invention relates to proteins with pteridine glycosyltransferase activity and an analysis method using the same. Since the proteins glycate tetrahydrobiopterin selectively through an enzyme reaction, the method enables quantitative analysis of tetrahydrobiopterin and oxides thereof at the same time or quantitative analysis of tetrabiopterin selectively. | 2011-03-10 |
20110059474 | METHOD FOR DETERMINING CARBOHYDRATE AND KIT FOR DETERMINING CARBOHYDRATE - It is intended to provide a method for determining a carbohydrate which enables more accurate determination of a carbohydrate. The invention for achieving this object is directed to a method for determining a carbohydrate using a digestive enzyme, characterized in that as the digestive enzyme, an animal-derived low-molecular-weight carbohydrate digestive enzyme is used. More specifically, the invention is directed to a method for determining a carbohydrate using a digestive enzyme, characterized by comprising a first reaction step using thermostable α-amylase; a second reaction step using protease and amyloglucosidase; and a third reaction step using an animal-derived low-molecular-weight carbohydrate digestive enzyme. | 2011-03-10 |
20110059475 | STABILISATION OF BLOOD CELL CONJUGATES - The invention relates to methods and kits for stabilising blood cell conjugates in blood samples for subsequent analysis. The invention particularly relates to methods and kits for use in fixing and stabilising platelet aggregates in blood samples, and methods for detecting the degree of platelet aggregation in a sample. The invention extends to kits for monitoring the efficacy of anti-thrombotic treatment regimes using platelet aggregation analysis. Two compositions with aliphatic aldehydes and a buffer are employed in a consecutive order. The second composition comprises addition a chelating agent. | 2011-03-10 |
20110059476 | BIOREACTOR FOR QUANTIFICATION OF HEADSPACE VOC CONTENT FROM CULTURES - A bioreactor for sampling the headspace above cells includes a glass reactor vessel having an interior space and a plurality of valves operatively coupled to the interior space of the glass reactor vessel. The bioreactor includes a sample holder configured to reside in the interior space. The interior space includes a charge of air with a known composition of volatile organic gases and, in some instances, doped with carbon dioxide. The sample holder may hold cells, bacteria, or viruses. The headspace may be sampled after incubation to determine the VOC content or content of specific VOC constituents. Examples include acetaldehyde and hexanaldehyde. | 2011-03-10 |
20110059477 | FLUORESCENT DYE-LABELED GLUCOSE BIOPROBE, SYNTHESIS METHOD AND USAGE THEREOF - Disclosed are a novel fluorescent glucose analogue, a method for the synthesis thereof and the use thereof. The novel fluorescent glucose analogue is labeled with fluorescent dye by O-1-glycosylation and via various linkers. The fluorescent glucose analogue can be applied to molecular bioimaging and a method for screening curative or preventive drugs for glucose metabolism-related diseases. | 2011-03-10 |
20110059478 | Orphan Nuclear Receptor - The present invention relates to a novel human orphan nuclear receptor that binds to a cytochrome P-450 monooxygenase (CYP) promoter and that is activated by compounds that induce CYP gene expression. The invention further relates to nucleic acid sequences encoding such a receptor, to methods of making the receptor and to methods of using the receptor and nucleic acid sequences encoding same. The invention also relates to non-human animals transformed to express the human receptor and to methods of using such animals to screen compounds for drug interactions and toxicities. | 2011-03-10 |
20110059479 | MODULATION OF THE INTEGRIN LINKED KINASE SIGNALING PATHWAY TO PROMOTE CARDIAC CELL PROLIFERATION AND SELF-RENEWAL - The invention relates to a process for identification, amplification and differentiation of cardiac stem cells by utilizing an ILK based protocol. The invention further relates to a process for post myocardial infarction (IVII) remodeling by way of the integrin linked kinase (ILK) signaling pathway. Still further, the invention relates to a process for affecting an ability to control and/or manipulate stem cell frequency, cellular fate, self-renewal, multilineage differentiation, and potential for oncogenesis in cardiac tissue derived from embryonic stem cells, fetal tissue or adult tissue comprising modulation of ILK signaling amplification whereby stem cell renewal and expansion results. | 2011-03-10 |
20110059480 | USE OF AN IN VITRO HEMODYNAMIC ENDOTHELIAL/SMOOTH MUSCLE CELL CO-CULTURE MODEL TO IDENTIFY NEW THERAPEUTIC TARGETS FOR VASCULAR DISEASE - Methods and devices for applying hemodynamic patterns to human/animal cells in culture are described. Hemodynamic flow patterns are measured directly from the human circulation and translated to a motor that controls the rotation of a cone. The cone is submerged in fluid (i.e., cell culture media) and brought into close proximity to the cells. Rotation of the cone creates time-varying shear stresses. This model closely mimics the physiological hemodynamic forces imparted on endothelial cells in vivo. A TRANSWELL coculture dish (i.e., a coculture dish comprising an artificial porous membrane) may be incorporated, permitting two, three, or more different cell types to be physically separated within the culture dish environment. In-flow and out-flow tubing may be used to supply media, drugs, etc. separately and independently to both the inner and outer chambers. The physical separation of the cell types permits each cell type to be separately isolated for analysis. | 2011-03-10 |
20110059481 | METHOD AND APPARATUS FOR DETERMINING RED BLOOD CELL INDICES OF A BLOOD SAMPLE UTILIZING THE INTRINSIC PIGMENTATION OF HEMOGLOBIN CONTAINED WITHIN THE RED BLOOD CELLS - A method for the determination of the red blood cell indices including the volume, and hemoglobin content and concentration for individual red blood cells, as well as red blood cell population statistics, including total number of red blood cells present in the sample, and mean values for each of the aforementioned indices within a substantially undiluted blood sample is provided. | 2011-03-10 |
20110059482 | Sampling Kit - The present invention relates to a kit for improving and facilitating sampling and handling of biological samples from sampling to analysis. The invention also relates to a method for selection and, optionally, enrichment of microbes for efficient and accurate analysis of a biological sample as well as a collection vessel. | 2011-03-10 |
20110059483 | Molecular Probe for Imaging of Pancreatic Islets and Use of the Same - To provide a molecular probe for imaging of pancreatic islets. A molecular probe for use in imaging of pancreatic islets is provided. The molecular probe includes any one of the following polypeptides; polypeptides represented by the following formulae (1), (5), and (9); and polypeptides having homology with the foregoing polypeptides; | 2011-03-10 |
20110059484 | Process for producing polypeptides - A process is described for producing a polypeptide heterologous to | 2011-03-10 |
20110059485 | Plasmids from Thermophilic Organisms, Vectors Derived Therefrom, and Uses Thereof - The present invention is directed to a replicative, thermostable plasmid. In particular, the present invention is directed to a replicative, thermostable plasmid comprising a sequence derived from the pB6A plasmid and at least one functional unit comprising a sequence that is not found in plasmid pB6A. | 2011-03-10 |
20110059486 | NON-SPLICING VARIANTS OF GP350/220 - Compositions comprising gp350 variant DNA and amino acid sequences are provided, as are vectors and host cells containing such sequences. Also provided is a process for producing homogeneous gp350 protein recombinantly and in the absence of production of gp220 protein, pharmaceutical compositions containing such protein and prophylactic treatments making use of such proteins. | 2011-03-10 |
20110059487 | ENGINEERED MICROORGANISMS AND METHODS OF USE - The present invention provides, among other things, engineered microorganisms and methods that allow efficient conversion of soy carbohydrates to industrial chemicals by fermentation. In some embodiments, the invention provides microbial cells engineered to have increased efficiency in utilizing a soy carbon source (e.g., soy molasses, soy meal, and/or soy hulls) as compared to a parent cell. In some embodiments, microbial cells are engineered to have altered (e.g., increased) expression or activity of one or more carbohydrate modifying enzymes (e.g., glycosidases). In some embodiments, microbial cells are engineered to have altered localization of carbohydrate modifying enzymes (e.g., glycosidases). In some embodiments, engineered microbial cells provided herein are used to produce industrial chemicals (e.g., surfactin) using soy components as primary or sole carbon sources. | 2011-03-10 |
20110059488 | Anti-MPL Antibodies - Anti-human Mpl antibodies were isolated and purified, and then anti-human Mpl diabodies and anti-human Mpl sc(Fv)2 were purified using genetic engineering techniques. Furthermore, the present inventors succeeded in humanizing anti-human Mpl sc(Fv)2. | 2011-03-10 |
20110059489 | METHOD FOR FERMENTATIVE PRODUCTION OF N-ACETYL-D-GLUCOSAMINE BY MICROORGANISM - N-Acetyl-D-glucosamine can be produced by cultivating a fungus capable of producing N-acetyl-D-glucosamine, such as | 2011-03-10 |
20110059490 | POLYMERASE COMPOSITIONS AND USES - A composition having nucleic acid polymerase activity, which comprises an active nucleic acid polymerase and an excess amount of a non-functional mutant nucleic acid polymerase protein, wherein the non-functional mutant nucleic acid polymerase protein stabilizes the active nucleic acid polymerase against loss of polymerase activity. | 2011-03-10 |
20110059491 | BETA-AMYLASE, GENE CODING THEREFOR AND MANUFACTURING METHOD THEREOF - To provide novel β-amylase derived from a microorganism and a gene thereof. β-amylase derived from | 2011-03-10 |
20110059492 | POLYPEPTIDES HAVING ALPHA-AMYLASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME - The present invention relates to isolated polypeptides having alpha-amylase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 2011-03-10 |
20110059493 | Methods for Making Simvastatin and Intermediates - The invention provides synthetic chemical and chemoenzymatic methods of producing simvastatin and various intermediates. In one aspect, enzymes such as hydrolases, e.g., esterases, are used in the methods of the invention. | 2011-03-10 |
20110059494 | D4 DESATURASES AND D5 ELONGASES - Disclosed are methods and compositions related to ONC-T18, D4-desaturases, D5 elongases, their isolation, characterization, production, identification, and use for fatty acid production, as well as organisms containing these compositions and organisms expressing them. | 2011-03-10 |
20110059495 | MANIPULATION OF AN ALTERNATIVE RESPIRATORY PATHWAY IN PHOTO-AUTOTROPHS - Exemplary methods for increasing TAG production in an algal cell during imbalanced growth conditions are provided. Some methods comprise knocking out an AOX gene, wherein the AOX gene produces an amino acid sequence having substantial similarity to the amino acid sequence of SEQ. ID. NO. 2. In further methods, the algal cell may be of genus | 2011-03-10 |
20110059496 | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE AND PHOSPHOGLYCERATE MUTASE PROMOTERS FOR GENE EXPRESSION IN OLEAGINOUS YEAST - Promoter regions associated with the | 2011-03-10 |
20110059497 | APPARATUS AND PROCESS FOR FERMENTATION OF BIOMASS HYDROLYSATE - A process for converting biomass hydrolysate into biofuel, the process comprising the steps of: obtaining a biomass hydrolysate solution comprising monosaccharides; immobilizing | 2011-03-10 |
20110059498 | Method and Device for Producing Electricity and Conversion Products, Such as Ethanol - The invention relates to a method for producing electricity and conversion products such as ethanol, comprising the steps of: i) separating a starch source into a starch-rich fraction and a residual fraction; ii) heating the starch-rich fraction for the purpose of gelling the starch; iii) releasing the gelled starch from the starch-rich fraction; iva) converting the gelled starch enzymatically into sugars; ivb) converting the sugars fermentatively into the conversion products; v) further processing the conversion products from the conversion medium; vi) generating biogas from residual fraction; vii) generating electricity and heat from biogas and/or residual fraction via cogeneration of heat and electricity; and viii) using the generated heat in one or more steps i) to vi). | 2011-03-10 |