| 10th week of 2012 patent applcation highlights part 43 |
| Patent application number | Title | Published |
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| 20120059142 | PREPARING POLYESTER ALCOHOLS - A process for preparing polyester alcohols by condensation of polytetrahydrofuran with aromatic dicarboxylic acids and/or their anhydrides and/or their esters, preferably isophthalic acid, phthalic acid and terephthalic acid and more preferably isophthalic acid, in the presence of a transesterification catalyst in a multi-stage operation at different pressure levels with at least one reaction stage at atmospheric pressure and at least one reaction stage at reduced pressure, where distillate is removed from the reaction system, comprises deactivating the catalyst after the polycondensation by using phosphoric acid in a molar ratio of 1:1 to 1:3.5 for catalyst to phosphoric acid. | 2012-03-08 |
| 20120059143 | PREPARING POLYESTER ALCOHOLS - The subject of the present invention is a process for preparing polyester alcohols by condensation of polytetrahydrofuran with aromatic dicarboxylic acids and/or their anhydrides in the presence of a transesterification catalyst in a multi-stage operation at different pressure levels with at least one reaction stage at atmospheric pressure and at least one reaction stage at reduced pressure, where distillate is removed from the reaction system, which process comprises heating the reaction mixture in two or more phases in the atmospheric-pressure reaction stage wherein the heating phases are interrupted by at least one phase in which the temperature is kept constant. | 2012-03-08 |
| 20120059144 | Process for the purification of polyol PFPE derivatives - A process for purifying a polyol(per)fluoropolyether derivative [polyol (P)] from a mixture (M) of hydroxyl(per)fluoropolyether derivatives, such polyol (P) comprising one or more hydroxyl(per)fluoropolyether derivatives [PFPEs (OH)] comprising at least one (per)fluoropolyoxyalkylene chain (chain R | 2012-03-08 |
| 20120059145 | STABILIZED BIOACTIVE PEPTIDES AND METHODS OF IDENTIFICATION, SYNTHESIS, AND USE - An intracellular selection system allows screening for peptide bioactivity and stability. Randomized recombinant peptides are screened for bioactivity in a tightly regulated expression system, preferably derived from the wild-type lac operon. Bioactive peptides thus identified are inherently protease- and peptidase-resistant. Also provided are bioactive peptides stabilized by a stabilizing group at the N-terminus, the C-terminus, or both. The stabilizing group can be a small stable protein, such as the Rop protein, glutathione sulfotransferase, thioredoxin, maltose binding protein, or glutathione reductase, an α-helical moiety, or one or more proline residues. | 2012-03-08 |
| 20120059146 | METHOD FOR THE PREPARATION OF CYCLOPEPTIDES - The present invention relates to a method for preparing cyclopeptides by means of protection with a substituted boronic acid. The present invention also discloses novel boronate esters of cyclopeptides of general formula (8). | 2012-03-08 |
| 20120059147 | METHOD FOR SITE-SELECTIVELY CLEAVING TARGET NUCLEIC ACID - There is provided a method for cleaving a target nucleic acid at a desired site using a metal ion or a metal ion complex as a catalyst for cleaving a nucleic acid (DNA, etc.), which has high site-selectivity, high reaction efficiency and low side-reactivity (non-specific reactivity), and is economical and convenient. The method for cleaving a target nucleic acid of the present invention comprises allowing a target nucleic acid to come into contact with a specific complex compound and a metal ion or a metal complex, or allowing a target nucleic acid to come into contact with a specific complex compound, to which a metal ion or a metal complex binds. | 2012-03-08 |
| 20120059148 | NON-NATURALLY OCCURRING LIPOPROTEIN PARTICLE - Non-naturally occurring lipoprotein particles, process for preparing such particles and uses thereof. | 2012-03-08 |
| 20120059149 | BRANCHED CHAIN-CONTAINING AROMATIC COMPOUND | 2012-03-08 |
| 20120059150 | METHODS FOR THE PRODUCTION OF APOLIPOPROTEINS IN TRANSGENIC PLANTS - Methods for the production of an apolipoprotein in plants are described. In one embodiment, the present invention provides a method for the expression of apolipoprotein in plants comprising:
| 2012-03-08 |
| 20120059151 | Non-Functional P2X7 Receptor - The present invention provides antibodies that specifically bind to P2X | 2012-03-08 |
| 20120059152 | PROTEIN SUBSTANCE HAVING TRIPLE HELIX STRUCTURE AND MANUFACTURING METHOD THEREFOR - As a result of dedicated research, the present inventors have successfully invented a collagen gene construct which can be easily purified and maintains a triple helix structure equivalent to that of naturally-occurring collagen while having a low molecular weight. Specifically, one-step purification by affinity purification is enabled because CR-D (a signal peptide) has a carbohydrate recognition domain. By substituting a portion of a human collagen structural gene of the present invention with the collagen-like structural gene portion of MBL, a low-molecular-weight collagen which maintains a triple helix structure and is thermally stable can be obtained with high purity and in large quantities. | 2012-03-08 |
| 20120059153 | METHODS FOR PREPARING STABLE DEOXYGENATED PEG-HEMOGLOBIN CONJUGATE SOLUTIONS COMPRISING AN ANTIOXIDANT - The present invention is a method for preparing stable HBOC solutions. Specifically, the method comprises the steps of deoxygenating a PEG-Hb conjugate and adding one or more antioxidants during or following the deoxygenating step to form a stabilized PEG-Hb conjugate. The Hb in the PEG-Hb conjugate is not crosslinked and the stabilized PEG-Hb conjugate has a p50 less than that of native SFH from the same animal source when measured under the same conditions. Specifically, the p50 is 6±2 mmHg or less than 10 mmHg. | 2012-03-08 |
| 20120059154 | ANTIGEN BINDING POLYPEPTIDES - The invention relates to a platform technology for production of antigen binding polypeptides having specificity for a desired target antigen which is based on the conventional antibody repertoire of species in the family Camelidae, and to antigen binding polypeptides obtained using this technology platform. In particular, the invention provides an antigen binding polypeptide comprising a VH domain and a VL domain, wherein at least one hypervariable loop or complementarity determining region (CDR) in the VH domain or the VL domain is obtained from a VH or VL domain of a species in the family Camelidae. | 2012-03-08 |
| 20120059155 | Method of Controlling O-Linked Glycosylation of Antibodies - A method for producing antibodies in fungal host cells is provided where the produced antibodies has a low degree of glycosylation. | 2012-03-08 |
| 20120059156 | METHOD OF PROTEIN NANOSTRUCTURE FABRICATION - A method of assembling a protein nanostructure on a surface including selectively patterning a surface with a fixation site, bringing a protein node into contact with the surface, and allowing the protein node to bond with the fixation site, so that the position and/or orientation of the protein node is constrained, and compositions. | 2012-03-08 |
| 20120059157 | METHOD FOR MANUFACTURING WATER RESISTANT OPTICALLY ANISOTROPIC FILM, AND IMAGE DISPLAY DEVICE - The present invention relates to a method for manufacturing a water resistant optically anisotropic film comprising: a water resistant treatment step of bringing an optically anisotropic film containing an organic dye having an anionic group into contact with a water resistant treatment liquid containing a multivalent metal salt or a compound having two or more nitrogen atoms in a molecule thereof; and a cleaning step of cleaning the optically anisotropic film after the water resistant treatment, using a cleaning liquid containing a hydrophilic organic compound. | 2012-03-08 |
| 20120059158 | STEROID COMPOUND - A steroid compound of the Formula (1): | 2012-03-08 |
| 20120059159 | DIFFERENTIATION THERAPY FOR SARCOMAS - Use of muscle-enriched/specific microRNAs for the treatment of sarcomas, as for example rhabdomyosarcomas, synovial sarcoma, alveolar soft part sarcoma, liposarcoma, and osteosarcoma, wherein the microRNAs are able to stop the development of neoplastic cells and to force the neoplastic cells to differentiate into terminally differentiated muscle cells. | 2012-03-08 |
| 20120059160 | NUCLEIC ACID PURIFICATION WITH A BINDING MATRIX - The present invention relates to methods, kits, and compositions for generating purified RNA samples and purified DNA samples. In particular, the present invention provides methods for generating a purified RNA or DNA sample from a sample containing both DNA and RNA molecules using a binding matrix that preferentially binds DNA or RNA in the presence of an acidic dilution buffer, or using a binding matrix that comprises acid zeolites, as well as compositions and kits for practicing such methods. | 2012-03-08 |
| 20120059161 | COMPOUNDS AND METHODS FOR TREATING AIDS AND HIV INFECTIONS - Macrocycle containing carbamate compounds that inhibit HIV proteolytic enzymes and processes for preparing them are described. Compositions and methods for treating a patient infected with HIV are described. | 2012-03-08 |
| 20120059162 | FUSED IMIDAZOLE DERIVATIVE HAVING TTK INHIBITORY ACTION - Provided are a compound represented by general formula (1) and having a TTK inhibitory action and a medicine containing the compound. In formula (1), (X, Y, V, W) is (—N═, ═CR | 2012-03-08 |
| 20120059163 | Non-linear opticaly active molecules, their synthesis, and use - In one aspect, the present invention provides a hyperpolarizable organic chromophore. The chromophore is a nonlinear optically active compound that includes a π-donor conjugated to a π-acceptor through a π-electron conjugated bridge. In other aspects of the invention, donor structures and acceptor structures are provided. In another aspect of the invention, a chromophore-containing polymer is provided. In one embodiment, the chromophore is physically incorporated into the polymer to provide a composite. In another embodiment, the chromophore is covalently bonded to the polymer, either as a side chain polymer or through crosslinking into the polymer. In other aspects, the present invention also provides a method for making the chromophore, a method for making the chromophore-containing polymer, and methods for using the chromophore and chromophore-containing polymer. | 2012-03-08 |
| 20120059164 | PYRAZINO[2,3-b]PYRAZINE mTOR KINASE INHIBITOR FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE mTOR/PI3K/AKT PATHWAY - Provided herein are Heteroaryl Compounds having the following structure: | 2012-03-08 |
| 20120059165 | INTERMEDIATE COMPOUND FOR SYNTHESIZING PHARMACEUTICAL AGENT AND PRODUCTION METHOD THEREOF - A production method of an optically active 2-{4-(5-substituted-oxadiazolyl) phenyl}morpholine which is useful as an intermediate for synthesizing a pharmaceutical agent is provided and the method comprises the following steps 1) to 4): 1) reacting a bromophenylmorpholine with a hexacyanoferrate(II) or a hydrate thereof at a temperature of from 110° C. to 140° C. in a reaction mixture comprising a Na | 2012-03-08 |
| 20120059166 | METHODS OF USING GPR119 RECEPTOR TO IDENTIFY COMPOUNDS USEFUL FOR INCREASING BONE MASS IN AN INDIVIDUAL - The present invention relates to methods of using GPR119 receptor to identify compounds useful for increasing bone mass in an individual. Agonists of GPR119 receptor are useful as therapeutic agents for treating or preventing a condition characterized by low bone mass, such as osteoporosis, and for increasing bone mass in an individual. Agonists of GPR119 receptor promote bone formation in an individual. | 2012-03-08 |
| 20120059167 | PROCESSES FOR PREPARING MORPHINAN-6-ONE PRODUCTS WITH LOW LEVELS OF ALPHA BETA-UNSATURATED COMPOUNDS - The present invention generally relates to processes for preparing highly pure morphinan-6-one products. The processes involve reducing the concentration of α,β-unsaturated ketone compounds present as impurities in morphinan 6 one products or reaction mixtures including morphinan 6 one compounds by treatment with a sulfur-containing compound. (A) | 2012-03-08 |
| 20120059168 | NAPHTHALENETETRACARBOXYLIC ACID DERIVATIVES AND THEIR USE AS SEMICONDUCTORS - The present invention relates to naphthalenetetracarboxylic acid derivates, to a process for their preparation and to their use, especially as an n-type semiconductor. | 2012-03-08 |
| 20120059169 | NOVEL CRYSTAL FORM OF TRICYCLIC BENZOPYRAN COMPOUND AND PRODUCTION METHOD THEREOF - Crystal forms of (3R,4S)-7-hydroxymethyl-2,2,9-trimethyl-4-(phenethylamino)-3,4-dihydro-2H-pyrano[2,3-g]quinolin-3-ol that are excellent as a drug, and production methods thereof. Production methods include crystallizing (3R,4S)-7-hydroxymethyl-2,2,9-trimethyl-4-(phenethylamino)-3,4-dihydro-2H-pyrano[2,3-g]quinolin-3-ol from an acetate ester solvent, an aliphatic hydrocarbon solvent, a nitrile solvent, an aromatic hydrocarbon solvent, a ketone solvent or an ether solvent, and crystal forms obtained according to the methods. | 2012-03-08 |
| 20120059170 | THIOPHENE ANALOGUES FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS - Compounds represented by formula I: | 2012-03-08 |
| 20120059171 | Process for Preparing Substituted Isoxazoline Compounds and Their Precursors - The present invention relates to a new method of preparing halogenated styrene compounds of formula (VIII) | 2012-03-08 |
| 20120059172 | NOVEL SOLVATE CRYSTALS - Acetone solvate crystals of trityl olmesartan medoxomil are provided. | 2012-03-08 |
| 20120059173 | DENDRITIC MOLECULES - The invention relates to novel dendritic molecules and methods of making them. The dendritic molecules comprise arms, each of which arms is a polymer. The dendritic molecules can be synthesised by way of a reasonably small number of versatile and reliable step-wise reactions, especially click chemistry reactions. Chemical and structural heterogeneity is possible in the dendritic molecule. The invention also provides for surface and interior functionalisation of the molecule. | 2012-03-08 |
| 20120059174 | PROCESS FOR PREPARING EPSILON-CAPROLACTONE AND 1,6-HEXANEDIOL - The invention relates to processes for preparing 1,6-hexanediol and very pure ε-caprolactone from a dicarboxylic acid solution (DCS), comprising the steps of (a) esterification of the DCS with alcohols, (b) partial catalytic hydrogenation of the esters, (c) distillative removal of 1,6-hexanediol and low boilers as the top product, and (d) cyclization of the 6-hydroxycaproic ester present in the bottoms fraction in the presence of a higher-boiling alcohol than caprolactone. | 2012-03-08 |
| 20120059175 | SYNTHESIS OF POLYCYCLIC PROCYANIDINS - The invention provides compounds that are A-type procyanidins. The compounds can be prepared by reacting flavylium salts with catechins or analogs thereof, for example, under anhydrous conditions in alcohol. | 2012-03-08 |
| 20120059176 | ANTI-INFLAMMATORY MODALITIES - Anti-inflammatory modalities are described with reference to select isoflavonoid compounds, compositions containing same and the use of said compounds and/or compositions in treatment, particularly for the treatment of inflammatory diseases and related conditions. | 2012-03-08 |
| 20120059177 | METHOD FOR PRODUCING 2-SUBSTITUTED TETRAHYDROPYRANOLS - The present invention relates to a process for the preparation of 2-substituted 4-hydroxy-4-methyltetrahydropyranols by reacting 3-methylbut-3-en-1-ol (isoprenol) with the corresponding aldehydes in the presence of a strongly acidic cation exchanger. Specifically, the present invention relates to a corresponding process for the preparation of 2-isobutyl-4-hydroxy-4-methyltetrahydropyran by reacting isoprenol with isovaleraldehyde. | 2012-03-08 |
| 20120059178 | OXIDATION OF FURFURAL COMPOUNDS - The disclosure pertains to a process for oxidation of furan aldehydes such as 5-hydroxymethyl)furfural (HMF) and derivatives thereof such as 5-(alkoxymethyl)furfural (AMF), 5-(aryloxymethyl)furfural, 5-(cycloalkoxy-methyl)furfural and 5-(alkoxycarbonyl)furfural compounds in the presence of dissolved oxygen and a Co(II), Mn(II), Ce(III) salt catalyst or mixtures thereof. The products from HMF can be selectively chosen to be predominantly 2,5-diformylfuran (DFF), particularly by inclusion of an aliphatic ketone, like methyl ethyl ketone, or can be further oxidized to 2,5-furandicarboxylic acid (FDCA) by the omission of methyl ethyl ketone and inclusion of bromide. When the reactant is an ether derivative of HMF the products are surprisingly ester derivatives where either both the ether and aldehyde functional groups have been oxidized or just the ether function group thereby producing one or both of 5-ester-furan-2-acids (i.e., 5-alkoxycarbonylfurancarboxylic acids) or 5-ester-furan aldehydes, (i.e., -alkoxycarbonylfurfurals a. k. a, 5-(alkoxycarbonyl)furfural). | 2012-03-08 |
| 20120059179 | PALLADIUM-CATALYZED ORTHO-FLUORINATION - A new method of ortho-fluorination where an aryl C—H bond is directly replaced by an aryl C-F bond in a palladium-catalyzed reaction is provided. The method includes the ortho-fluorination of a triflamide protected benzylamine, a palladium catalyst, such as Pd(OTf) | 2012-03-08 |
| 20120059180 | Extraction and Winterization of Lipids from Oilseed and Microbial Sources - A process for purifying a lipid composition having predominantly neutral lipid components having at least one long chain polyunsaturated fatty acid is disclosed. The process employs contacting the lipid composition with a polar solvent, such as acetone, wherein the solvent is selected such that contaminants are less soluble in the solvent than is the long chain polyunsaturated fatty acid. The process is typically conducted at cooler temperatures, including about 0° C. Upon precipitation of the contaminants from the lipid composition, a separation is conducted to remove the precipitated material from the lipid composition. The long chain polyunsaturated fatty acids can include ARA, DPA, EPA, and/or DHA. The process of the present invention effectively winterizes lipid compositions, thereby reducing the tendency of such compositions to become hazy. | 2012-03-08 |
| 20120059181 | HYBRID, ORGANIC-INORGANIC, CRYSTALLINE, POROUS SILICATES AND METAL-SILICATES - The present invention relates to new hybrid, organic-inorganic hybrid silicates and metal-silicates characterized by a crystalline structure containing structural units having formula (a), wherein R is an organic group possibly containing one or more element T selected from Group IIIB, IVB, VB and from transition metals. A process starting from cyclic trisilanes for the preparation of said materials, is also described. These materials can be used as molecular sieves, adsorbents, in the field of catalysis, in the field of electronics, in the field of sensors, in the area of nanotechnology. | 2012-03-08 |
| 20120059182 | Catalysts, Methods of Makting Catalysts, and Methods of Use - Embodiments of the present disclosure provide for acyclic diaminocarbenes (ADCs) catalysts such as those shown in FIG. | 2012-03-08 |
| 20120059183 | PHOSPHORYLCHOLINE GROUP-CONTAINING COMPOUND, METHOD OF MANUFACTURING A PHOSPHORYLCHOLINE GROUP-CONTAINING COMPOUND, SURFACE-MODIFYING AGENT, AND A METHOD OF MODIFYING A SURFACE USING A SURFACE-MODIFYING AGENT - A phosphorylcholine group-containing compound that is a structure having a phosphorylcholine group represented by the following formula 1 and an amino group or a group derived from an amino group in an identical compound. | 2012-03-08 |
| 20120059184 | System for Controlling the Reactivity of Boronic Acids - A protected organoboronic acid includes a boron having an sp | 2012-03-08 |
| 20120059185 | PROCESS FOR PRODUCING POLYETHER-POLYESTER BLOCK COPOLYMER - The present invention discloses a process for producing a polyether-polyester block copolymer with a di(C 1-C 4)alkyl ester of aromatic dicarboxylic acid, an aliphatic diol or aliphatic polyol and a polyether having at least one terminal hydroxyl group in an inert solvent. In the present invention, the inert solvent 5 is used to prevent the di(C 1-C 4)alkyl ester of aromatic dicarboxylic acid from sublimation instead of excessive polyol, such that the subsequent removal of excessive polyol under high temperature and high vacuum is avoided. | 2012-03-08 |
| 20120059186 | RADIATION CURABLE COMPOSITIONS - A composition comprising at least one curable compound (I) advantageously having a refractive index Formula (I) of at least 1.60 and obtained from the reaction of A at least one aromatic polyisocyanate, B at least one monofunctional alcohol or amine, C at least one further monofunctional alcohol or amine different from B, D at least one diol or diamine, and E optionally a hydroxyl group containing (meth)acrylate, the compound (I) comprising at least one curable functional group selected from the group consisting of carbon-carbon double bonds and epoxy groups. | 2012-03-08 |
| 20120059187 | Process for Preparation of 2-Fluoroacrylic Esters - According to the present invention, there is provided a production process of a 2-fluoroacrylic ester including: a bromination step of converting a 2-fluoropropionic ester to a 2-bromo-2-fluoropropionic ester by reaction of the 2-fluoropropionic ester with a nitrogen-bromine bond-containing brominating agent in the presence of a radical initiator; and a dehydrobromination step of reacting the 2-bromo-2-fluoropropionic ester with a base. It is not necessary in this process to adopt very-low-temperature conditions and to use a stoichiometric amount of expensive reagent. The target 2-fluoroacrylic ester can be thus produced at low cost. | 2012-03-08 |
| 20120059188 | HALOGENATED ANALOGUES OF ANTI-FIBROTIC AGENTS - The present invention relates to halogenated compounds of formula (I) with the substituents as described within the specification. The compounds may be useful as anti-fibrotic agents. The present invention also relates to methods for their preparation. | 2012-03-08 |
| 20120059189 | PROCESS FOR THE PRODUCTION OF L-CARNITINE TARTRATE - The invention relates to a process for the production of L-carnitine tartrate, wherein the L-carnitine tartrate is precipitated from a reaction mixture comprising L-carnitine and tartaric acid dissolved in ethanol, the ethanol having a water content of less than 5% (w/w). | 2012-03-08 |
| 20120059190 | NOVEL NITRATION OF TETRACYCLINES - The invention in one embodiment is directed to a method of preparing a compound of formula 1, | 2012-03-08 |
| 20120059191 | ZEOLITE-PALLADIUM COMPLEX, METHOD FOR PRODUCING THE SAME, CATALYST CONTAINING THE COMPLEX, AND METHOD FOR PRODUCING A COUPLING COMPOUND BY USING THE CATALYST - There is provided a substance having much higher catalytic activity for a Suzuki-Miyaura coupling reaction than conventional heterogenous catalysts. The present invention provides a zeolite-palladium complex including USY-zeolite and Pd supported on the USY-zeolite, the Pd having a Pd—Pd coordination number of 4 or less and an oxidation number of 0.5 or less. | 2012-03-08 |
| 20120059192 | METHOD FOR SEPARATING CAROTENOID - The present invention provides a method for collecting a carotenoid from a culture of a carotenoid-producing bacterium at high yield. Specifically, the present invention provides a method for separating a carotenoid comprising a step of precipitating a concentrate containing the carotenoid from a culture of a carotenoid-producing bacterium under acidic conditions; and a method for producing a carotenoid comprising the steps of precipitating a concentrate containing the carotenoid from a culture of a carotenoid-producing bacterium under acidic conditions and collecting the carotenoid from the obtained precipitate. | 2012-03-08 |
| 20120059193 | PROCESS FOR PRODUCING 2-(CYCLOHEX-1'-ENYL)CYCLOHEXANONE - The present invention discloses a process for producing 2-(cyclohex-1′-enyl)cyclohexanone by an auto-condensation of cyclohexanone at a certain temperature in the presence of a certain solid acidic catalyst. | 2012-03-08 |
| 20120059194 | PRODUCTION METHOD FOR UBIQUINONE POWDER FOR USE IN PREPARATIONS AND PRODUCT THEREOF - Disclosed are a production method for a ubiquinone powder for use in preparations, including Step 1 of compression molding a ubiquinone crystal powder at a linear molding pressure of from 0.6 to 2.5 tons/cm to obtain a compressed fragment; and Step 2 of grinding the compressed fragment obtained in Step 1 to obtain a powder; and a ubiquinone powder for use in preparations, which is obtained by the subject production method. According to the subject production method, it becomes possible to provide a ubiquinone powder for use in preparations for medicines and health foods, which has a high bulk density, a small angle of repose and excellent handling properties and fluidity, without using an additive such as an excipient, a binder and the like. | 2012-03-08 |
| 20120059195 | CATALYST COMPOSITION FOR HYDROFORMYLATION REACTION AND HYDROFORMYLATION PROCESS USING THE SAME - The present invention relates to a catalyst composition for hydroformylation reaction and a hydroformylation process using the same. In the hydroformylation process using the catalyst composition according to the present invention, increased catalytic stability and high catalytic activity can be obtained, and the selectivity of iso-aldehyde produced can be desirably controlled. | 2012-03-08 |
| 20120059196 | METHOD FOR PREPARING A TERPENYLCYCLOHEXANOL - A method for preparing a terpenylcyclohexanol using a terpenylphenol is described. A method for preparing a terpenylcyclohexanol by hydrogenation of a terpenylphenol is also described wherein the method includes hydrogenating the latter in a liquid phase, in the presence of a Raney nickel catalyst including residual aluminium and doped with a mixture of iron and chromium. | 2012-03-08 |
| 20120059197 | ALCOHOL PRODUCTION PROCESS INTEGRATING ACETIC ACID FEED STREAM COMPRISING WATER FROM CARBONYLATION PROCESS - In one embodiment, the invention is to a process for producing ethanol, comprising the step of providing from a distillation column in a carbonylation process a purified acetic acid stream comprising up to 25 wt. % water. The process further comprises the step of hydrogenating acetic acid of the purified acetic acid stream in the presence of a catalyst and under conditions effective to form a crude ethanol product comprising ethanol and water. Ethanol is recovered from the crude ethanol product. | 2012-03-08 |
| 20120059198 | DERIVATISATION OF CARBON - A molecular species is covalently attached to elemental carbon by exposing the carbon to a reaction mixture containing a strong base and a compound of the formula (I) or (II) in which X denotes a covalently attached atom or group capable of forming an X | 2012-03-08 |
| 20120059199 | CONTINUOUS LOW-TEMPERATURE PROCESS TO PRODUCE TRANS-1-CHLORO-3,3,3-TRIFLUOROPROPENE - Disclosed is process for the production of (E) 1-chloro-3,3,3-trifluoropropene (HCFO-1233zd(E)) by conducting a continuous reaction without the use of a catalyst. Also disclosed is an integrated system for producing hydrofluoro olefins, particularly 1233zd(E). The manufacturing process includes six major unit operations: (1) a fluorination reaction of HCC-240fa (in continuous or semi-batch mode) using HF with simultaneous removal of by-product HCl and the product 1233zd(E); (2) recycle of unreacted HCC-240fa and HF together with under-fluorinated by-products back to (1); (3) separation and purification of by-product HCl; (4) separation of excess HF back to (1); (5) purification of final product, 1233zd(E); and (6) isomerization of by-product 1233zd(Z) to 1233zd(E) to maximize the process yield. | 2012-03-08 |
| 20120059200 | Integrated Process to Coproduce Trans-1-Chloro-3,3,3-Trifluoropropene, Trans-1,3,3,3-Tetrafluoropropene, and 1,1,1,3,3-Pentafluoropropane - Disclosed is an integrated manufacturing process to co-produce (E)1-chloro-3,3,3-trifluoropropene, (E)1,3,3,3-tetrafluoropropene, and 1,1,1,3,3-pentafluoro-propane starting from a single chlorinated hydrocarbon feed stock, 240fa. The process includes a combined liquid or vapor phase reaction/purification operation which directly produces (E)1-chloro-3,3,3-trifluoropropene (1233zd(E)) from 240fa. In the second liquid phase fluorination reactor 1233zd(E) is contacted with HF in the presence of catalyst to produce 1,1,1,3,3-pentafluoropropane (245fa) with high conversion and selectivity. A third reactor is used for dehydrofluorination of 245fa to produce (E)1,3,3,3-tetrafluoropropene (1234ze(E)) by contacting in the liquid phase with a caustic solution or in the vapor phase using a dehydrofluorination catalyst. This operation may be followed by one or more purification processes to recover the 1234ze(E) product. | 2012-03-08 |
| 20120059201 | METHODS TO PRODUCE 3,3,3-TRIFLUOROPROPENE - Disclosed is a process for the preparation of 3,3,3-trifluoropropene comprising the steps of; (1) fluorination of 240fa to form 245fa; (2) conversion of 245fa to a cis/trans mixture of 1234ze; (3) hydrogenation of the cis/trans mixture of 1234ze to form 254fb; and (4) dehydrofluorination of 254fb to produce 3,3,3-trifluoropropene. Alternatively or additionally, a second process for the preparation of the desired compound comprises the following steps; (1) fluorination of HCC-240fa to form HCFC-244fa; (2) conversion of 244fa to a cis/trans mixture of HFO-1234ze; (3) hydrogenation of the cis/trans mixture of 1234ze to form HFC-254fb; and (4) dehydrofluorination of 254fb to produce 3,3,3-trifluoropropene. | 2012-03-08 |
| 20120059202 | PROCESS FOR THE MANUFACTURE OF HYDROFLUOROOLEFINS - In this invention we are disclosing a process for the synthesis of hydrocchlorofluoro olefins (HCFO) and/or hydrofluoroolefins (HFO). The process is based on the gas phase, noncatalytic fluorination of hydrochlorofluoropropenes to form hydrofluoropropenes. | 2012-03-08 |
| 20120059203 | MANUFACTURING PROCESS FOR IODINATED AROMATIC COMPOUNDS - Disclosed is a method for preparing an iodinated aromatic compound. More specifically, disclosed is a method of preparing an iodinated aromatic compound by iodinating an aromatic compound in the presence of oxygen over a zeolite catalyst, in which the aromatic compound and a monoiodo analog of the aromatic compound, or a monoiodo aromatic compound, as raw materials, are allowed to react with iodine. In comparison with a method in which only the aromatic compound is used as a raw material without adding the monoiodo compound, the disclosed method can increase the productivity of diiodo compounds and the selectivity to a p-diiodo compound and, at the same time, suppress side reactions, thus lengthening the life span of the catalyst. | 2012-03-08 |
| 20120059204 | METHOD FOR PURIFYING ORGANIC SOLVENT - The present invention relates to a method for purifying a compound selected from a compound represented by the following general formula [1] or [2], a saturated aliphatic hydrocarbon having no substituent, or kerosene: | 2012-03-08 |
| 20120059205 | Biogenic Fuel And Method Of Making Same - A method of producing from a biomass mesitylene-isopentane fuel is provided. A biomass may be fermented to form acetone. The acetone is converted in a catalytic reactor to mesitylene and mesityl oxide. The mesitylene is separated in a phase separator and the organic face containing mesityl oxide is sent to a dehydration reactor, then to a demethylation reactor, and finally to a hydrogenation reactor from which isopentane is recovered. This isopentane is then mixed with the mesitylene to form the final mesitylene-isopentane fuel. The catalytic reaction with acetone employs catalysts of either niobium, vanadium or tantalum. | 2012-03-08 |
| 20120059206 | PROCESS FOR PRODUCTION OF ETHYLBENZENE FROM TOLUENE AND METHANE - A process for making ethylbenzene and/or styrene by reacting toluene with methane is disclosed. In one embodiment the process can include reacting toluene with methane to form a product stream comprising ethylbenzene and further processing the ethylbenzene to form styrene in an existing styrene production facility. | 2012-03-08 |
| 20120059207 | Production of Polyolefins - A method for preparing a liquid polyolefin includes contacting a feedstock comprising at least one olefin monomer with a catalyst system to produce a reactor effluent stream, filtering the reactor effluent stream, washing a created filter cake with a wash fluid comprising at least one hydrocarbon liquid; and recovering the liquid polyolefin. The catalyst system may be any conventional polyolefin catalyst system, and in a preferred embodiment, the catalyst system contains at least one activated metallocene catalyst. The reactor effluent stream comprises at least one liquid polyolefin, residual catalyst, and unreacted olefin monomer. | 2012-03-08 |
| 20120059208 | MODIFIED ZINC FERRITE CATALYST AND METHOD OF PREPARATION AND USE - A catalyst for oxidative dehydrogenation of organic compounds is provided by forming a solution of catalyst precursor components comprised of Fe | 2012-03-08 |
| 20120059209 | PROCESS FOR THE CONTINUOUS HYDROGENATION OF TRIGLYCERIDE CONTAINING RAW MATERIALS USING A NICKEL AND MOLYBDENUM-BASED CATALYST - Process for the continuous hydrogenation of triglyceride containing raw materials in a fixed bed reactor system having several catalyst beds arranged in series and comprising at least e hydrogenation catalyst comprising an active phase constituted by a nickel and molybdenum element. The raw material feed, hydrogen containing gas and diluting agent are passed together through the catalyst beds at hydrogenation conditions. The raw material feed stream as well as the stream of hydrogen containing gas are divided into an equal number of different partial streams. These are each passed to one catalyst bed in such a manner that the weight ratio of diluting agent to raw material feed is essentially the same at the entrance of all catalyst beds and does not exceed 4:1. The claimed process is preferably conducted at low temperatures and allows the utilization of existing units due to the low recycle ratio. | 2012-03-08 |
| 20120059210 | Rotate-to-advance catheterization system - A system of rotate-to-advance medical devices including catheters, dilators, occluders, stents, suprapubic catheters and camera introducers configured with external screw threads and depending substantially on rotation for means of advancement and emplacement in mammalian genitourinary and gastrointestinal passages and organs. | 2012-03-08 |
| 20120059211 | Method of diagnosing and treatment of hypertension - A method for the provision of electrical, electromagnetic or magnetic stimulation to the T8 and T9 vertebrae and related off-shoot vertebrae of the human spine, through the use of probes, related induction coils and electrodes, imparting one or more of low frequency, high frequency, AC or magnetic fields and pulses, and their combinations, through the sympathetic and parasympathetic nervous systems, to diagnose and treat hypertension activity of the cells in any one or combination of the vascular wall, kidney or adrenal glands, to innervate and affect such cells to approximate normal function, inclusive of sodium regulation and regulated release of hormones from such cells of the adrenal gland as well as regulation of vascular tone through improved function of various ion channels and improved sympathic nervous system function. | 2012-03-08 |
| 20120059212 | CONDUIT DEVICE FOR USE WITH A VENTRICULAR ASSIST DEVICE - The present invention is a conduit device designed to be placed within a wall of a heart, such as through a prepared opening or hole in the heart wall. The conduit is hollow and extends to form a sleeve over a portion of the heart pump, such as a VAD, which traverses the heart wall and enters a chamber of the heart. The conduit provides for a simplified and noninvasive approach to removal and/or replacement of the heart pump. | 2012-03-08 |
| 20120059213 | Cannula Systems and Methods - Disclosed herein is a cannula assembly for directing the flow of material from an organ chamber, e.g., blood from the left chamber of the heart, and methods of placing the cannula assembly in fluidic communication with the chamber. The cannula assembly includes an elongate tubular member and a coupling assembly disposed at the distal end of elongate tubular member. The elongate tubular member includes a lumen extending from a distal opening at the distal end to a proximal opening at the proximal end. The coupling assembly includes a retaining element and a retention member configured to cooperate with each other and with the portion of the organ wall surrounding the opening in the wall to couple or anchor cannula system to the wall and to provide fluidic communication between the distal opening of the elongate tubular member and the organ chamber. | 2012-03-08 |
| 20120059214 | Active hydraulic ventricular attaching support system - An active hydraulic ventricular attachable support system includes a net cover for surrounding a ventricle and is formed by hollow tubes. All the hollow tubes can completely communicate with each other or form a plurality of independent areas, and the interior of each independent area is intercommunicating, while the independent areas are not communicating with each other. The system as a whole is positioned on the surface of the heart. The hollow tubular structure can be filled with various kinds of liquid of different physical characteristics, and then the corresponding reaction pressure generated can be applied to the ventricle and the surfaces of the heart. The system also can be incorporated with local administration. | 2012-03-08 |
| 20120059215 | METHOD OF COLLECTING SEMEN FROM LAB ANIMALS AND ARTIFICIAL INSEMINATION METHOD THEREOF - The present invention relates to a method of collecting semen from the epididymis or the testis of a lab animal and an artificial insemination method thereof. The present invention relates to a new applicable method in the animal production field using artificial insemination. Since the present invention solves the problems of the conventional method of artificial insemination of lab animals, it is excellent in terms of the pregnancy rate and productivity; is time-efficient; and is superior in economic and industrial respects by preventing a huge economic loss due to the costs for maintaining the mass breeding of animals. | 2012-03-08 |
| 20120059216 | REMOTELY ADJUSTABLE GASTRIC BANDING SYSTEM - A fluid reservoir for use in a remotely adjustable gastric banding system comprises a housing and a flexible reservoir pouch positioned within the housing. The flexible reservoir pouch is coupled to an inflatable portion of a gastric band via flexible tubing. A pump coupled to the flexible reservoir pouch facilitates filling and draining the inflatable portion of the gastric band. The pump may be located within or outside of the housing. A receiving coil may be coupled to the housing, and the receiving coil forms a loop around the housing. The receiving coil receives radio frequency signals to drive the pump. A circuit board may be disposed in the housing for driving the pump to move the fluid between the flexible reservoir pouch and the inflatable portion of the gastric band. A portion of the circuit board may be a flexible circuit board to allow the housing to flex. | 2012-03-08 |
| 20120059217 | PELVIC IMPLANTS AND METHODS OF IMPLANTING THE SAME - In one embodiment, an implant is configured to be placed within a body of a patient. The implant includes a support member. The support member is configured to be placed adjacent a vaginal apex of a patient. The support member has a length sufficient to extend the length of the vaginal apex but not of a length sufficient to extend from the vaginal apex to a location between a vagina of the patient and a rectum of the patient. The implant also includes first and second arm members coupled to the support member. The arm members are configured to be coupled to bodily tissue of the patient to help secure the implant within the body of the patient. | 2012-03-08 |
| 20120059219 | BIPOLAR RESECTION DEVICE HAVING SIMPLIFIED ROTATIONAL CONTROL AND BETTER VISUALIZATION - An oval or ovoid electrode is used in a resectoscope. A longer dimension of the electrode preferably extends in a direction that is perpendicular to the direction in which the electrode is moved during tissue resection. | 2012-03-08 |
| 20120059220 | APPARATUS AND METHOD FOR FOUR DIMENSIONAL SOFT TISSUE NAVIGATION IN ENDOSCOPIC APPLICATIONS - A surgical instrument navigation system is provided that visually simulates a virtual volumetric scene of a body cavity of a patient from a point of view of a surgical instrument residing in the cavity of the patient. The surgical instrument navigation system includes: a surgical instrument; an imaging device which is operable to capture scan data representative of an internal region of interest within a given patient; a tracking subsystem that employs electro-magnetic sensing to capture in real-time position data indicative of the position of the surgical instrument; a data processor which is operable to render a volumetric, perspective image of the internal region of interest from a point of view of the surgical instrument; and a display which is operable to display the volumetric perspective image of the patient. | 2012-03-08 |
| 20120059221 | ENDOSCOPIC FORM DETECTION DEVICE AND FORM DETECTING METHOD OF INSERTION SECTION OF ENDOSCOPE - An endoscopic form detection device includes a posture detecting section configured to detect a posture of each of sensor units based on measurement data in the sensor unit, and a linear form detecting section configured to detect a detected linear form of an inserting section on an assumption that a form between the respective sensor units is a linear link whose dimension is equal to an inter-sensor dimension based on the detected posture of each of the sensor units. The endoscopic form detection device includes a form correcting section configured to compensate at least a position of each of the sensor units by using a particle filter, and configured to detect a corrected form obtained by correcting the detected linear form. | 2012-03-08 |
| 20120059222 | IMAGING DEVICE AND METHOD OF CLEANING AN ILLUMINATION WINDOW OF THE IMAGING DEVICE - In an imaging device for capturing an image by applying illuminating light emitted from a light source to a part to be observed through a light exit window and receiving light coming from the part to be observed when the illuminating light is applied, a light exit window cleaning unit discharges a liquid toward the light exit window to clean the light exit window in response to an instruction to start application of the illuminating light. | 2012-03-08 |
| 20120059223 | LARYNGSCOPE INSERTION SECTION WITH TUBE GUIDE - A laryngoscope insertion section includes an elongate member and a tube guide having a moveable guiding member, located transversely of the elongate member and moveable relative to adjacent elongate member to adjust the path of a retained endotracheal tube, thereby facilitating intubation. | 2012-03-08 |
| 20120059224 | HAND-HELD EAR VACUUM WITH CAMERA AND VIDEO DISPLAY - An ear speculum that includes a body having an ear-contacting tip with an opening; a light providing member; a viewing member; and a vacuum intake port, wherein the members and intake port are provided within the ear speculum with the vacuum intake port occupying a larger portion of the of the cross-sectional area of the ear speculum opening than the light providing or viewing members to facilitate removal of material from an ear canal. Also, an otoscope that includes a head; an ear speculum as described herein in operative association with the head; an image detector in image communication with the viewing member; a suction source in vacuum communication with the vacuum intake port; and a light source in illumination communication with the light providing member. Also, a system and method for removing material or debris from an ear canal using the otoscope described herein. | 2012-03-08 |
| 20120059225 | EXPANDABLE SPACE-OCCUPYING TISSUE RETRACTORS - This document provides methods and materials for retracting tissue during a minimally invasive surgical procedure (e.g., an endoscopic surgical procedure). For example, methods and materials for using an expandable space-occupying tissue retractor during an endoscopic surgical procedure such as a laparoscopic cholecystectomy procedure or a NOTES procedure are provided. | 2012-03-08 |
| 20120059226 | SURGICAL RETRACTORS WITH ILLUMINATION - A surgical retractor has a plurality of lights affixed to a blade thereof, that can illuminate a wound of a patient during operation. The lights can be on a distal end of the blade and/or an interior or exterior surface of the blade, so that the user can control the lighting on the retractor to suit the particular needs of a particular application. The lights can be powered by a battery compartment within the handle, allowing for untethered operation of the retractor. | 2012-03-08 |
| 20120059227 | DIRECTING A USER TO A MEDICAL RESOURCE - A processor-implemented method, system, and/or computer program product directs a user using a physiological sensor to a needed medical resource. A real-time state of a medical condition of a user is determined based on readings from a physiological sensor on a user. A processing system correlates the real-time state of the medical condition of the user to a medical resource, which has been predetermined to have a capability of ameliorating the real-time state of the medical condition of the user. Directions are then sent, to the user, for a temporally nearest medical resource that has been predetermined to have the capability of ameliorating the real-time state of the medical condition of the user. | 2012-03-08 |
| 20120059228 | METHODS FOR DETECTING ENDOMETRIOSIS - The method of the present invention is directed towards detecting endometriosis in a mammalian subject. This method comprises the following steps; taking a sample from the mammal, measuring the level of sphingomyelin (SM) or phosphatidylcholine (PC), or combinations thereof, in the sample, comparing the measured levels of SM or PC, or combinations thereof, to predetermined levels, and diagnosing the mammal based on the comparison. This method may also comprise the following steps: taking a sample from the mammal, measuring the level of F11 Receptor (F11R) in the sample, comparing the measured level of F11R to a predetermined level, and diagnosing the mammal based on the comparison. | 2012-03-08 |
| 20120059229 | DEVICE AND METHOD FOR MEASURING MILD PERCEPTUAL IMPAIRMENT - A device and method for measuring mild perceptual impairment of a human subject, in which a stimulus having at least one parameter is applied to the human subject. The human subject produces a response to the stimulus indicative of a perception by the human subject of the at least one parameter of the stimulus. The response of the human subject is then processed in view of determining if the human subject suffers from mild perceptual impairment. | 2012-03-08 |
| 20120059230 | WEARABLE BODY MONITOR TO PROVIDE INDICATORS OF AN INDIVIDUAL - The invention is a system for detecting, monitoring, and reporting an individual's physiological or contextual status. The system works deriving a physiological or contextual status parameter of an individual using the system. The derivation utilizes two sensed parameters of the individual. The system is able to present the derived parameter in relation to any other sensed parameters, entered information, life activities data, or other derived data. | 2012-03-08 |
| 20120059231 | DEVICE FOR PERFORMING AT LEAST ONE MEDICAL FUNCTION - A device for performing at least one medical function on a user is proposed. The device has at least one medical functional element that is designed to perform the medical function. The medical function is selected from a diagnostic, a therapeutic and a surgical function. The device has at least one evaluation and control part that comprises at least one actuation component for controlling the medical function. The evaluation and control part has at least one casing and at least one battery receptacle. The battery receptacle comprises at least one electrical energy reservoir, more particularly at least one battery. The battery receptacle is designed to be opened irreversibly by the user for removing the energy reservoir. | 2012-03-08 |
| 20120059232 | IMPLANTABLE OPTICAL GLUCOSE SENSING - Apparatus is provided, including a support ( | 2012-03-08 |
| 20120059233 | DISPOSABLE AND DETACHABLE SENSOR FOR CONTINUOUS NON-INVASIVE ARTERIAL BLOOD PRESSURE MONITORING - A sensor system for continuous non-invasive arterial blood pressure (CNAP) is provided. The CNAP-sensor comprises of a base portion and a detachable and disposable portion. The base portion is connected to a control system. The disposable portion is for attachment to a human body part. The CNAP-sensor system includes a photo-plethysmographic (PPG) system having at least one light source, at least one light detector, electrical supplies, light coupling systems, one or more connectors, and a cuff including air supplies. | 2012-03-08 |
| 20120059234 | Blood Chamber for an Optical Blood Monitoring System - An extracorporeal blood chamber for an optical blood monitoring system includes an opaque chamber body in order to prevent inaccuracies when measuring oxygen saturation levels due to light ducting, which can occur at low oxygen saturation levels and low hematocrit levels. In one embodiment, the blood chamber need not include a moat as is present in conventional blood chambers. | 2012-03-08 |
| 20120059235 | Animal Instrumentation - An approach to instrumentation and telemetry of physiological and physical parameters of an animal and its environment has particular application to horses. This approach improves the effectiveness of one or more of evaluation, diagnosis, care conditioning or monitoring of animals because it does not require use of restrictive equipment such as force plates or treadmills, and it can provide objective and quantitative data that is complete, accurate, precise and reproducible, and this data can be obtained under real-world conditions, for either or both of more or less real-time or continuous processing of data to perform the monitoring or diagnosis. That is, in such an approach objective and quantitative data can be collected under real-world conditions and this data can be processed and the information can be displayed in a form that is familiar to experts in real-time locally, or can be stored for subsequent retrieval or transmitted for remote review. | 2012-03-08 |
| 20120059236 | IMPLANTABLE DEVICE FOR REAL-TIME MONITORING OF GLYCEMIA AND DOSAGE - An implantable device for constant collection and dosage of glycemia with real-time monitoring, with no need of external collection by punctioning which is constituted by a metal compartment, hermetically sealed with the cap, containing at least a micro-computerized mini-center fed by the battery or similar, which is externally rechargeable. The device contains a sensor which collects a portion of the circulating blood and reads glycemia levels in real time, sending reading information through the transmission component. The device is connected to an inlet catheter with its collecting edge duly implanted by means of punctioning at the subclavian vein, to deviate a small flow of blood to pass through within said dosage and monitoring device, thus allowing the sensor to verify the glycemic dosage and following its natural course by exiting the exit catheter through the outlet edge, thus returning to the blood current within said subclavian vein. | 2012-03-08 |
| 20120059237 | SYSTEM AND METHOD FOR MONITORING BLOOD GLUCOSE LEVELS NON-INVASIVELY - A system and method is described for non-invasive monitoring of blood glucose levels. The system includes a pulse-sensor unit configured to detect a pulse wave travelling through a blood vessel and a processor unit configured to determine pulse wave velocity, to calculate the blood density and so to determine blood glucose level. Various embodiments include pulse-sensor arrays and wearable units configured to communicate with insulin pumps worn about the person of the subject. | 2012-03-08 |
| 20120059238 | System for transcutaneous monitoring of intracranial pressure - A system for measuring and converting to an observer intelligible form an internal physiological parameter of a patient. The invention allows transcutaneous telemetry of intracranial pressure via a system which includes a patient implanted sensor module and an external processing module, optically coupled to the sensor module via an external coupling module. A sensor within the sensor module transduces the measured pressure and a near infrared emitter transmits the telemetry when interrogated by the external coupling module. A set of tuned inductor-crystal circuits comprised in part of a cylindrical crystal oscillator whose resonant frequency is sensed by a dipper circuit arrangement is provided. Power for the sensor module is derived inductively through rectification of a transcutaneously-applied high-frequency alternating electromagnetic field generated within the external coupling module. A computer within the processing module calculates the physiological parameter from the telemetry signal and represents this data in numerical, graphical, or analog format. | 2012-03-08 |
| 20120059239 | BODY MOTION DETECTION DEVICE AND METHOD, AS WELL AS RADIOGRAPHIC IMAGING APPARATUS AND METHOD - An image obtaining unit obtains a plurality of radiographic images, which at least partially overlap with one another, taken by carrying out a plurality of imaging operations with respect to an identical subject. An imaging information obtaining unit obtains imaging information representing imaging conditions and an imaged subject during the imaging operations. A body motion index value obtaining unit obtains a body motion index value, which indicates a body motion of the subject during imaging of the radiographic images, based on the imaging information. | 2012-03-08 |
| 20120059240 | METHOD FOR PREPARATION OF MICELLAR HYBRID NANOPARTICLES FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS AND COMPOSITIONS THEREOF - The disclosure provides a long-circulating, micellar hybrid nanoparticles (MHN) that contain MN, QD, and the anti-cancer drug doxorubicin (DOX) within a single polyethylene glycol (PEG)-phospholipid micelle and provide the first examples of simultaneous targeted drug delivery and dual-mode NIR-fluorescent and MR imaging of diseased tissue in vitro and in vivo. | 2012-03-08 |
| 20120059241 | SYSTEMS AND METHODS FOR MAKING AND USING A STEERABLE IMAGING SYSTEM CONFIGURED AND ARRANGED FOR INSERTION INTO A PATIENT - A medical imaging assembly includes a sheath with a lumen. An imaging core is disposed at one end of an imaging core shaft disposed in the lumen. The imaging core shaft bends along a shape memory region when the imaging core is extended from the lumen. The imaging core includes a transducer to image patient tissue, a mirror to redirect acoustic signals between the transducer and patient tissue, and a magnet to drive rotation of the mirror. The magnet is rotatable by a magnetic field generated at the location of the magnet. An imaging core shaft rotator rotates the imaging core shaft such that, when the imaging core is extended from the lumen, rotation of the imaging core shaft causes radial rotation of the imaging core about the sheath. The imaging core shaft rotator includes rotatable imaging core shaft magnets fixedly disposed over a portion of the imaging core shaft. | 2012-03-08 |
| 20120059242 | Hybrid MR/PET Scanner With Patient Table Split Cable Feed - A hybrid magnetic resonance (MR) and positron emission tomography (PET) imaging system reduces likelihood of artifact distortion in PET images attributable to MR local coil cables and connectors in the patient table. MR local coil cables coupling the MR scanner and the MR local coil connectors are oriented so that they are outside the scanner field of view when performing PET scans. | 2012-03-08 |
