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10th week of 2013 patent applcation highlights part 46
Patent application numberTitlePublished
20130059986GRAFT COPOLYMER WITH PH DEPENDENT BEHAVIOUR - A graft copolymer with pH dependent behavior of formula 1 Comprises, (i) a backbone having the formula 1 [A2013-03-07
20130059987Functionalized Silicon Carbide And Functionalized Inorganic Whiskers For Improving Abrasion Resistance Of Polymers - Inorganic particulate or whiskers are surface-treated to facilitate receptivity to covalent bonding with a coupling agent. Surface treatment forms reactive groups that enable the inorganic particulate or whiskers to covalently bond to a reactive group of the coupling agent. The coupling agent also contains organofunctional groups, which in some examples may be covalently bonded to a polymer matrix by way of crosslinking or by co-polymerizing the functionalized particulate or whiskers together with polymer precursors. The resulting polymeric materials exhibit markedly improved abrasion resistance as well as other improved properties.2013-03-07
20130059988REMENDABLE INTERFACES FOR POLYMER COMPOSITES - Functionalized polymer matrix and/or reinforcement materials that are capable of a thermoreversible Diels-Alder reaction are useful for making composite materials. Also disclosed is a composite material which includes one or both of functionalized reinforcement materials and functionalized polymer matrix materials, as well as a method for repairing a composite material including the step of thermally treating the composite material at a temperature sufficient to react a functionality on one of the reinforcement material and the polymer matrix material with another functionality via a Diels-Alder reaction. A method of making a composite material including functionalizing one or both of a reinforcing material and a polymer matrix material with a first reactive group, providing a second reactive group capable of undergoing a Diels-Alder reaction with the first reactive group and reacting the first and second reactive groups to form a composite material, is also described.2013-03-07
20130059989Polyolefin Compositions and Articles Prepared Therefrom, and Methods for Making the Same - The invention provides a composition comprising at least one olefin multi-block interpolymer; at least one functionalized olefin-based polymer; and optionally at least one thermoplastic polyurethane. The invention also provides for articles prepared from the inventive compositions and for methods for making the same.2013-03-07
20130059990SOLID SUPPORT-POLYMETHYLALUMINOXANE COMPLEX, METHOD FOR PRODUCING SAME, OLEFIN POLYMERIZATION CATALYST, AND METHOD FOR PRODUCING POLYOLEFIN - Disclosed is a solid support-polymethylaluminoxane complex exhibiting a higher polymerization activity than a conventional substance and being homogeneous. Also disclosed is a method for producing an olefin-based polymer having a favorable quality using the complex and a transition metal compound. The complex comprises a coating layer containing polymethylaluminoxane and trimethylaluminum on the surface of a solid support. The coating layer comprises a solid polymethylaluminoxane composition in which (i) the content of aluminum is in a range of 36 to 41 mass % and (ii) the molar fraction of methyl groups derived from a trimethylaluminum moiety to the total number of moles of methyl groups is 12 mol % or less. Also disclosed is an olefin polymerization catalyst comprising the complex and a transition metal compound represented by general formula (III): MR2013-03-07
20130059991CATALYST FOR STEREOSELECTIVE OLEFIN POLYMERIZATION AND METHOD FOR MANUFACTURING STEREOSELECTIVE POLYOLEFIN - A stereoselective olefin polymerization catalyst contains a complex represented by Formula (1):2013-03-07
20130059992High Vinyl Terminated Propylene Based Oligomers - This invention relates to a co-oligomer having an Mn of 300 to 30,000 g/mol comprising 10 to 90 mol % propylene and 10 to 90 mol % of ethylene, wherein the oligomer has at least X % allyl chain ends, where: 1) X=(−0.94 (mole % ethylene incorporated)+100), when 10 to 60 mole % ethylene is present in the co-oligomer, and 2) X=45, when greater than 60 and less than 70 mole % ethylene is present in the co-oligomer, and 3) X=(1.83*(mole % ethylene incorporated)−83), when 70 to 90 mole % ethylene is present in the co-oligomer. This invention also relates to a homo-oligomer, comprising propylene, wherein the oligomer has: at least 93% allyl chain ends, an Mn of about 500 to about 20,000 g/mol, an isobutyl chain end to allylic vinyl group ratio of 0.8:1 to 1.2:1.0, and less than 100 ppm aluminum. This invention also relates to a process of making homo-oligomer, comprising propylene, wherein the productivity is greater than 4500 g/mmol Hf (or Zr)/hour.2013-03-07
20130059993CATALYST FOR POLYMERIZATION OF NORBORNENE MONOMERS, METHOD FOR PRODUCING NORBORNENE POLYMER, METHOD FOR PRODUCING NORBORNENE COPOLYMER, NORBORNENE POLYMER AND TRANSITION METAL COMPLEX - A catalyst for a polymerization of norbornene monomers includes a transition metal complex represented by a formula (1). A method for producing a norbornene copolymer includes copolymerizing first norbornene monomers corresponding to a first monomer unit represented by a formula (2) and second norbornene monomers corresponding to a second monomer unit represented by a formula (3) in a presence of the catalyst. The transition metal complex is preferably (π-allyl){2-[N-(2,6-diisopropylphenyl)iminomethyl]phenolate}palladium, (π-allyl){2-[N-(2,6-diisopropylphenyl)iminomethyl]-4-fluorophenolate}palladium, (π-allyl)[2-(N-phenyliminomethyl)phenolate]palladium or (π-allyl){2-[N-(2,6-diisopropylphenyl)iminomethyl]-6-methylphenolate}palladium.2013-03-07
20130059994PORPHYRIN COPOLYMER CONTAINING QUINOXALINE UNIT, PREPARATION METHOD AND USES THEREOF - A porphyrin copolymer containing quinoxaline unit, preparation method and uses thereof are disclosed. The copolymer has the structural formula (I), wherein R2013-03-07
20130059995PROCESS FOR PREPARING HIGH-REACTIVITY ISOBUTENE HOMO- OR COPOLYMERS - Preparation of high-reactivity isobutene homo- or copolymers with a content of terminal vinylidene double bonds per polyisobutene chain end of at least 50 mol % and a polydispersity of preferably 1.05 to less than 3.5, by polymerizing isobutene or an isobutene-comprising monomer mixture in the presence of an aluminum trihalide-donor complex effective as a polymerization catalyst or of an alkylaluminum halide-donor complex, especially of an aluminum trichloride-donor complex, said complex comprising, as the donor, an organic compound with at least one ether function or a carboxylic ester function.2013-03-07
20130059996Boron-Containing PI-Electron Materials Incorporating Formally Aromatic and Neutral Borepin Rings - The synthesis, functionalization and characterization of borepin-based extended pi-electron molecules is disclosed. Bulky substituents shielded the vacant boron p-orbitals thus allowing synthetic manipulation and purification under ambient lab conditions. The presently disclosed borepin-containing compounds displayed reversible cathodic electrochemistry and can be viewed as n-type analogues to bent acene hydrocarbons.2013-03-07
20130059997SOIL ADSORPTION POLYMERS - Soil adsorption polymers and method for making same are provided.2013-03-07
20130059998Poly(Ester Amide) Macromers and Polymers Thereof - Amino acid-based poly(ester amide) (PEA) macromers (e.g., functional PEA macromers) and methods for preparing amino acid-based poly(ester amide) (PEA) macromers. The functional PEA macromers can comprise functional groups such as hydroxyl, amine, sulfonic acids, carboxyl, thiol and acryloyl at the two terminuses of the PEA macromers. The content of the terminal functional groups on the macromers can be precisely controlled by adjusting the molar ratio of reactive monomers. The resulting versatility of these new functional PEA macromers can be used to fabricate a wide range of PEAs and PEA hybrid derivatives with very different chemical, physical, mechanical, thermal and biological properties. The functional PEA macromers can also be polycondensed into forming block PEA polymers.2013-03-07
20130059999GOLD-POLYMER NANOSTRUCTURE-IMMOBILIZED SCANDIUM CATALYST AND ITS USE - The present invention provides a Scandium catalyst that can be used in water or water-soluble organic solvent with no leaching of Scandium. Provided is a gold-polymer nanostructure-immobilized Scandium catalyst, which is formed by preparing, in liquid phase, a mixture comprising gold clusters with from 1 to 50 nm of diameter, disulfide monomer, sulfonic acid salt of disulfide and Lewis acid metal compound represented by ScY2013-03-07
20130060000METHODS FOR PRODUCING CROSSLINKABLE SILYL GROUP-CONTAINING POLYOXYALKYLENE POLYMERS - Embodiments of the invention provide for a method of producing a silylated polyoxyalkylene polymer having at least one crosslinkable silyl group and at least one hydroxyl group in each molecule. The method comprises providing a polyoxyalkylene polymer having at least one unsaturated group and at least one alcoholic hydroxyl group in each molecule, wherein the polyoxyalkylene polymer includes an impurity double metal cyanide complex mixed therein, and wherein the polyoxyalkylene polymer has not been treated with a metal-coordinating compound; and adding to the polyoxyalkylene polymer a compound having a hydrogen-silicon bond and a crosslinkable silyl group in each molecule and a hydrosilylation catalyst to thereby carry out a hydrosilylation reaction, wherein the hydrosilyation reaction is performed in an absence of a metal-coordinating compound.2013-03-07
20130060001CATALYSTS FOR THE PREPARATION OF CARBONATES FROM EPOXIDES AND CO2 - A macrocycle based on β-diketimines, a process for preparing the inventive macrocycle, an uncharged macrocyclic dimetallic complex based on the inventive macrocycle, and a process for preparing the uncharged macrocyclic dimetallic complex, the use of the uncharged macrocyclic dimetallic complex as a polymerization catalyst in the polymerization of carbon dioxide with one or more epoxides, a process for preparing polycarbonates by reacting carbon dioxide with one or more epoxides in the presence of the inventive uncharged macrocyclic dimetallic complex, and a polycarbonate prepared by the process according to the invention.2013-03-07
20130060002PROCESS FOR WORKING UP REACTION OUTPUTS FROM THE HYDROGENATION OF EDDN OR EDMN - A process is disclosed for separating the output from the reaction of EDDN or EDMN with hydrogen in the presence of THF, a catalyst, TETA or DETA, water, and optionally organic compounds having higher and lower boiling points than TETA or DETA. Hydrogen is removed, and the output is supplied to a distillation column DK1 in which an azeotrope, optionally comprising organic compounds with a boiling point lower than TETA or DETA, is removed from the top. A product comprising TETA or DETA is removed from the bottom and passed cinto a distillation column DK2, removing THF. A stream comprising TETA or DETA passes from the bottom of DK2. The DK1 azeotrope is condensed. Phase separation is induced by the addition of an organic solvent essentially immiscible with water, and the mixture is separated. The organic phase is recycled into DK1 and the water phase is discharged.2013-03-07
20130060003CHEMICAL PREPARATION OF POLYUBIQUITIN CHAINS - The present invention discloses a process for the preparation of a Poly-ubiquitin chain, this process comprising ligating a Ubiquitin thioester Ubm-SR with a Ubiquitin Ubq. Further are disclosed poly-ubiquitin chains prepared according to this process, in particular poly-ubiquitin chains containing at least one unnatural amino acid.2013-03-07
20130060004Novel Process For The Preparation Of Leuprolide And Its Pharmaceutically Acceptable Salts Thereof - The present invention relates to a novel process for the preparation of Leuprolide or its pharmaceutically acceptable salts thereof by solid and solution phase peptide synthesis (Hybrid approach). The present invention also relates to a process for the preparation of Leuprolide or its pharmaceutically acceptable salts thereof by synthesizing the peptide fragments by solid phase (7 and 5 amino acids fragment) and solution phase (2 and 4 amino acids fragment) respectively. The final solution phase condensation of these peptide fragments (7+2 and 5+4) led to a nonapeptide Leuprolide in the protected form. The present invention further relates to novel peptide fragements—Pyr-His(Trt)-Trp(Boc)-Ser(tBu)-Tyr(tBu)-DLeu-Leu-OH (Fragment-11); H-Arg(Pbf)-Pro-NHEt (Fragment-I11); Pyr-His(Trt)-Trp(Boc)-Ser(tBu)-Tyr(tBu)-DLeu-Leu-Arg(Pbf)-Pro-NHEt (Protected Leuprolide) (Fragment-IV); Pyr-His(Trt)-Trp(Boc)-Ser(tBu)-Tyr(tBu)-OH (Fragment-V); H-DLeu-Leu-Arg(Pbf)-Pro-NHEt (Fragment-VI) and process for the preparation thereof.2013-03-07
20130060005COMPOSITIONS AND METHODS FOR INHIBITING THE INTERACTION BETWEEN CFTR AND CAL - The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention provides peptides and peptidomimetics that selectively inhibit the interaction between CAL and mutant CFTR proteins, thereby stabilizing the CFTR and facilitating transport of the same to the cell surface.2013-03-07
20130060006Natural Flavour Enhancers and Methods for Making Same - The present invention pertains to the use of certain flavour enhancing compounds obtainable from an 2013-03-07
20130060007METHOD OF PROTEIN REFOLDING WITH ION EXCHANGE RESINS AND THE APPLICATION OF THE SAME - A method for protein refolding using a like-charged ion exchange resins as an additive to facilitate protein refolding. The ion exchange resins mentioned herein includes charged group with the same sign as the target protein to be refolded and the method for refolding an unfolded protein. The method has some advantages described as below: firstly, no new impurity is introduced into the final product of protein due to ion exchange resins used in the present invention is insoluble and easy to remove by settlement or centrifugation, secondly; the key material used in the present invention, ion exchange resins, is easy to recycle after regeneration; thirdly, compared with the refolding method by chromatographic techniques, the current method requires no expensive chromatograph facilities and is simple to perform at lower cost, which is a desirable character for preparative refolding of therapeutic proteins expressed in bacteria as inclusion bodies.2013-03-07
20130060008METHOD FOR SILK FIBROIN GELATION USING SONICATION - This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after the ultrasonication treatment. Biological materials, including viable cells, or therapeutic agents can be encapsulated in the hydrogels formed from the process and be used as delivery vehicles.2013-03-07
20130060009PROCESS FOR OBTAINING ANTIBODIES - The present disclosure relates to a method for the manufacture of recombinant antibody molecules comprising culturing a host cell sample transformed with an expression vector encoding a recombinant antibody molecule; adding an extraction buffer to the sample; and subjecting the sample to a heat treatment step; wherein the pH of the sample is detected after addition of the extraction buffer, and optionally adjusted, to ensure that the pH of the sample is 6 to 9 prior to the heat treatment step.2013-03-07
20130060010DESIGN AND DEVELOPMENT OF MASKED THERAPEUTIC ANTIBODIES TO LIMIT OFF-TARGET EFFECTS - In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a masked monoclonal antibody (mAb) is provided, which includes a therapeutic mAb and a mask, the mask comprising protein A and protein L attached by a protease cleavable linker.2013-03-07
20130060011FC-FREE ANTIBODIES COMPRISING TWO FAB FRAGMENTS AND METHODS OF USE - The present invention relates to bispecific antibodies comprising at least two fab fragments, wherein the first Fab fragment comprises at least one antigen binding site specific for a first antigen; and the second Fab fragment comprises at least one antigen binding site specific for a second antigen, wherein either the variable regions or the constant regions of the second Fab heavy and light chain are exchanged; and wherein the bispecific antibody is devoid of a Fc domain; methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.2013-03-07
20130060012METHOD FOR PURIFYING BONE MORPHOGENETIC PROTEIN - The present invention relates to a method for purifying a protein belonging to the TGF-β, superfamily, preferably BMP, and more preferably BMP-2. According to the invention, the number of purification steps is reduced and the purification process is simplified, compared to the conventional BMP-2 purification method. Thus, the time required for purification can be shortened and the cost can be reduced. In addition, the invention solves the problem that as the time for purification increases and the number of purification steps increases, BMP-2 is degraded by protease or lost during purification steps, resulting in a decrease in the final yield of BMP-2. Thus, the invention increases the final yield of BMP-2. In addition, according to the invention, although the number of purification steps is reduced, BMP-2 having high purity is obtained in high yield by optimizing and using filtrations and chromatographies, and columns, types and concentrations of buffers, and a cut-off size of membrane used in diafiltration, which are different from those of the conventional BMP-2 purification method.2013-03-07
20130060013Compounds useful for treating neurodegenerative disorders - The present invention provides compounds of formula I:2013-03-07
20130060014SURFACE MODIFIED INORGANIC MATERIAL AND PRODUCING METHOD THEREOF - A surface-modified inorganic material and a preparation method thereof. A surface-modified inorganic material is provided which is obtained by allowing an organosilane compound having allyl or an allyl derivative to react with an inorganic material, particularly solid silica or ITO glass, in the presence of an acid and an organic solvent, to introduce an organic group into the inorganic material even at room temperature, as well as a preparation method thereof. The invention can effectively introduce the organic group into the inorganic material even at room temperature, and thus is very effective in introducing compounds having a thermally sensitive functional group, for example, natural compounds or proteins. It is possible to introduce various organic groups into an inorganic material and to separate and purify organic molecule-bonded organosilane compounds using a silica gel column to effectively bond them to inorganic materials.2013-03-07
20130060015METHOD FOR PRODUCING GLUCOSIDES - The present invention relates to methods for producing glucosides directly from glucose or a polysaccharide comprising glucose as a structural unit. The present invention provides a method comprising reacting glucose or a polysaccharide comprising glucose as a structural unit with a compound represented by R—OH in the presence of a supercritical or subcritical carbon dioxide to produce glucosides and a method comprising dissolving or suspending glucose or a polysaccharide comprising glucose as a structural unit in an organic solvent containing a compound represent by R—OH and reacting the glucose or polysaccharide with the compound represented by R—OH in the presence of a supercritical or subcritical carbon dioxide to produce glucosides.2013-03-07
20130060016GENETICALLY MODIFIED PLANTS WHICH SYNTHESIZE A LOW AMYLOSE STARCH WITH INCREASED SWELLING POWER - The present invention relates to genetically modified monocotyledonous plant cells and plants whose starch has an apparent amylose content of less than 5% by weight and an increased activity of a protein with the activity of a starch synthase II and an increased activity of a protein with the activity of a glucan, water dikinase. Such plants synthesize starch with an increased hot-water swelling power. Methods and processes for the generation/preparation of these plant cells, plants, starches and flours are likewise subject matter of the present invention.2013-03-07
20130060017METHODS FOR SYNTHESIZING LABELED COMPOUNDS - The invention relates to methods for synthesizing compounds on solid supports. The invention also relates to synthesizing labeled compounds, such as those used in the field of radiopharmaceuticals. The invention relates to methods for synthesizing halogenated radiopharmaceuticals such as fludeoxyglucose (also known as fluorodeoxyglucose or FDG).2013-03-07
20130060018PROCESS FOR THE PREPARATION OF SUCRALOSE - The present invention provides a method for preparing colorless sucralose, wherein 4,1′,6′-trichloro-4,1′,6′-trideoxy-galacto sucrose-6- acetate containing colored impurities formed during chlorination of sucrose-6-acetate is treated with sodium hypochlorite, where sodium hypochlorite acts both as a decolorizing agent and as a reagent for the ester hydrolysis.2013-03-07
20130060019Compounds for Use in Treating Neurodegenerative Disorders, Synthesis Thereof, and Intermediates Thereto - The present invention provides methods of making a compound of formula II:2013-03-07
20130060020Compounds useful for treating neurodegenerative disorders - The present invention provides compounds of formula I:2013-03-07
20130060021Compounds useful for treating neurodegenerative disorders - The present invention provides compounds of formula I:2013-03-07
20130060022Compounds useful for treating neurodegenerative disorders - The present invention provides compounds of formula I:2013-03-07
20130060023Compounds useful for treating neurodegenerative disorders - The present invention provides compounds of formula I:2013-03-07
20130060024Compounds useful for treating neurodegenerative disorders - The present invention provides compounds of formula I:2013-03-07
20130060025CERTAIN HETEROCYCLES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE - Provided are compounds of Formula I:2013-03-07
20130060026PROCESSES AND INTERMEDIATES FOR MAKING A JAK INHIBITOR - This invention relates to processes and intermediates for making {1-{1-[3-fluoro-2-(trifluoromethyl)isonicotinoyl]piperidin-4-yl}-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile, useful in the treatment of diseases related to the activity of Janus kinases (JAK) including inflammatory disorders, autoimmune disorders, cancer, and other diseases.2013-03-07
20130060027TETRAHYDROISOQUINOLINES AND INTERMEDIATES THEREFOR - Disclosed are processes for preparing tetrahydroisoquinolines, intermediates useful in the preparation of tetrahydroisoquinolines, processes for preparing such intermediates, and a crystalline form of 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine. Also disclosed are pharmaceutical compositions comprising tetrahydroisoquinolines, methods of using tetrahydroisoquinolines in the treatment of depression and other conditions and methods for obtaining the crystalline form.2013-03-07
20130060028NOVEL PROCESSES - This invention relates to methods of making a compound of formula (I) and intermediates for same2013-03-07
20130060029QUINAZOLINONE DERIVATIVES USEFUL AS VANILLOID ANTAGONISTS - There is described a process for the manufacture of compounds of the formula I2013-03-07
20130060030PROCESS FOR THE PREPARATION OF HIGHLY PURE CRYSTALLINE IMATINIB BASE - A process for the preparation of highly pure crystalline imatinib base form- N of Formula (I) is disclosed. Imatinib base of this invention is suitable for conversion to pharmaceutically acceptable salts.2013-03-07
20130060031PROCESS FOR THE PREPARATION OF HIGHLY PURE AMBRISENTAN - The present invention relates to an improved and novel process for the preparation of highly pure (>99.8%) (+)-2(S)-(4,6-dimethylpyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionic acid (Ambrisentan) of formula (I).2013-03-07
20130060032POTASSIUM FLUORIDE DISPERSION AND PROCESS FOR PRODUCING FLUORINE-CONTAINING ORGANIC COMPOUND USING THE SAME - A potassium fluoride dispersion essentially consisting of potassium fluoride and an aprotic organic solvent having a boiling point higher than that of methanol, which is obtainable by mixing a mixture containing potassium fluoride and 5 to 50 parts by weight of methanol per 1 part by weight of potassium fluoride with the aprotic organic solvent followed by concentrating the obtained mixture, and a process for producing a fluorine-containing organic compound comprising contacting an organic compound having at least one group capable of being substituted nucleophilically with a fluorine atom with the potassium fluoride dispersion.2013-03-07
20130060033LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, ELECTRONIC DEVICE, LIGHTING DEVICE, AND HETEROCYCLIC COMPOUND - Provided is a novel heterocyclic compound which has excellent heat resistance and can be used as a host material for a light-emitting substance (a substance emitting fluorescence or a substance emitting phosphorescence). A light-emitting element includes a heterocyclic compound which includes one dibenzo[f,h]quinoxaline ring, one ring having a hole-transport skeleton, and two to eight benzene rings. Note that in the above structure, the molecular weight of the heterocyclic compound is greater than or equal to 564 and less than or equal to 1000.2013-03-07
20130060034ALIPHATIC PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS WITH BETA AGONIST ACTIVITY - The present application provides sodium channel blockers exemplified by the following structure:2013-03-07
20130060035RUTHENIUM BASED COMPLEXES - The present invention relates to the field of catalysis and, more particularly, to a ruthenium carbonate complex of formula [Ru(diene)(C02013-03-07
20130060036PROCESS FOR PRODUCTION OF QUINUCLIDINE COMPOUNDS - Provided is a production method for a cis-QMF, which has a low environmental burden and is industrially advantageous. Specifically provided is a production method for a cis-type 2-alkylspiro(1,3-oxathiolane-5,3′)quinuclidine hydrochloride, including: reacting a cis-trans isomer mixture of 2-alkylspiro(1,3-oxathiolane-5,3′)quinuclidine with p-nitrobenzoic acid; resolving the resultant product to produce a cis-type 2-alkylspiro(1,3-oxathiolane-5,3′)quinuclidine p-nitrobenzoate; and converting the p-nitrobenzoate into a hydrochloride.2013-03-07
20130060037MATERIALS WITH AZA-DIBENZOTHIOPHENE OR AZA-DIBENZOFURAN CORE FOR PHOLED - A new class of compounds containing aza-dibenzothiophene or aza-dibenzofuran are provided. The compounds may be used in organic light emitting devices giving improved stability, improved efficiency, long lifetime and low operational voltage. In particular, the compounds may be used as the host material of an emissive layer having a host and an emissive dopant, or as a material in an enhancement layer.2013-03-07
20130060038PREPARATION OF DIHYDROPYRROL DERIVATIVES AS INTERMEDIATES - The invention is concerned with a new scalable process for the preparation of compounds of formula I comprising a new process for the preparation of the key intermediate, a dihydropyrrole derivative formula II or a salt thereof.2013-03-07
20130060039AZABICYCLIC CARBAMATES AND THEIR USE AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS - The invention relates to novel benzothiophene-, benzofuran-, and indole ureas and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning, and/or memory.2013-03-07
20130060040Salt and Crystalline Forms Thereof of a Drug - A crystalline form of a drug, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.2013-03-07
20130060041SYNTHESIS OF SUBSTITUTED PYRAZOLINE CARBOXAMIDINE DERIVATIVES - This invention relates to organic chemistry, in particular to processes for the preparation of pyrazoline carboxamidine derivatives of formula (I), known as potent 5-HT6 antagonists. The invention also relates to novel intermediates of these compounds. wherein the symbols have the meanings given in the description.2013-03-07
20130060042PROCESS FOR PRODUCING PYRIPYROPENE DERIVATIVES - Disclosed is a process for efficiently producing pyripyropene derivatives having acyloxy at the 1-position and 11-position and hydroxyl at the 7-position. The process comprises selectively acylating hydroxyl at the 1-position and 11-position of a compound represented by formula B1 through one to three steps with an acylating agent in the presence or absence of a base.2013-03-07
20130060043PREPARATION METHOD OF FLUORO-SUBSTITUTED DEUTERATED DIPHENYLUREA - A fluoro-substituted deuterated diphenylurea compound, especially 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-2-(N-(methyl-d3))picolinamide, preparing method and use for treating or preventing tumor and relative diseases thereof.2013-03-07
20130060044METHOD FOR PREPARING DEUTERATED DIPHENYLUREA - Disclosed are an intermediate compound of N-(1,1,1-trideuterated methyl)phthalimide, and its use in the preparation of deuterated diphenylurea derivative.2013-03-07
201300600451, 2, 4-TRIAZOLE DERIVATIVES AND THEIR ANTI MYCOBACTERIAL ACTIVITY - Invention provides antitubercular compounds selected from propargylated 1,2,3 triazoles of Formula I, wherein, X is sulfur (S) or a sulphone (A), n, m represent independently an integer O or 1, with the provision that when ‘n’ is 1, ‘m’ is 1; R1 is hydrogen; C1-C6 linear or branched alkyl group optionally substituted with aryl group; halogen; or aryl group optionally substituted with —OCH3, halogen, and nitro; R2 and R3 are selected from the group consisting of hydrogen, C1-C6 alkyl optionally substituted with heterocyclic ring of 5 to 6 ring atoms containing one to three hetero atoms selected from oxygen, sulfur, nitrogen, which may be substituted with alkyl, arylalkyl, linear or branched alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or allyl or propargyl groups consisting of 1 to 6 carbon atoms; Z is C1-C6 alkyl optionally substituted with heterocyclic ring of 1 to 6 ring atoms, containing one to three hetero atoms selected from oxygen, sulfur, nitrogen, which may be substituted with arylalkyl, linear or branched alkenyl, substituted alkenyl, alkynyl, substituted alkynyl allyl or propargyl groups consisting of 1 to 6 carbon atoms; with the provision that when ‘m’ is 1, and ‘n’ is zero; R1 is selected from the group consisting of hydrogen, halogen; C1-C6 linear or branched alkyl group optionally substituted with aryl group or aryl group optionally substituted with —OCH3, halogen, and nitro, R2 and R3 are selected from the group consisting of hydrogen, C1-C6 alkyl optionally substituted with heterocyclic ring of 5 to 6 ring atoms containing one to three hetero atoms selected from oxygen, sulfur, nitrogen, which may be substituted with alkyl, arylalkyl, linear or branched alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or allyl or propargyl groups consisting of 1 to 6 carbon atoms; Z is selected from the group consisting of halogen, C1-C6 linear or branched alkyl group optionally substituted with heterocyclic ring of 1 to 6 ring atoms, containing one to three hetero atoms selected from oxygen, sulfur, nitrogen, wherein the heterocyclic ring may further be substituted with halogen, alkyl, arylalkyl.2013-03-07
20130060046TRIMETHINE CYANINE AND ITS USE - The present invention relates to a trimethine cyanine represented by the formula (1):2013-03-07
20130060047NOVEL METHODS FOR THE PREPARATION OF P2X7R ANTAGONISTS - Disclosed are novel methods for the synthesis of N-substituted indol-3-yl-alkylamide compounds which act as P2X7R antagonists, said methods involving the rearrangement of an oxime intermediate.2013-03-07
20130060048CRYSTALLINE D-ISOGLUTAMYL-D-TRYPTOPHAN AND THE MONO AMMONIUM SLAT OF D-ISOGLUTAMYL-D-TRYPTOPHAN - A process for making pure crystalline D-isoglutamyl-D-tryptophan is provided which includes the step of deprotecting essentially pure N-tert-butoxycarbonyl-D-isoglutamyl-D-tryptophan or its diester to yield essentially pure D-isoglutamyl-D-tryptophan. A process is also provided for the preparation of pure mono ammonium salt of D-isoglutamyl-D-tryptophan from essentially pure N-tert-butoxycarbonyl-D-isoglutamyl-D-tryptophan. D-isoglutamyl-D-tryptophan, ammonium salt (2013-03-07
20130060049METHOD FOR PREPARING (S)-4-HYDROXY-2-OXO-1-PYRROLIDINE ACETAMIDE - A preparation method of (S)-4-hydroxy-2-oxo-1-pyrrolidine acetamide is provided, which includes the steps of preparing the crude product and crystallizing, wherein acetone and water are used as solvents in the step of crystallizing. The (S)-oxiracetam prepared by the method of the present invention has high purity of more than 99.3% and low impurity of 0-0.5%, based on the percentages of the mass. According to the method of the present invention, with regard to the way of charging materials, adding inorganic base only just a few times is easier to handle and more convenient to the industrial manufacturing and application.2013-03-07
20130060050PROCESS FOR PRODUCING THIOPHENE COMPOUND AND INTERMEDIATE THEREOF - Provided are γ-ketosulfide compounds represented by the formula (5):2013-03-07
20130060051Process For The Preparation Of L-Lactide Of High Chemical Yield And Optical Purity - A process for the synthesis of 100% optically pure L(+)-lactide catalyzed by zinc and tin metal catalysts of less than 150 micron particle size is disclosed. The L-lactide obtained was further purified to obtain lactide of 100% optical purity and acid impurities less than 10 meq/kg.2013-03-07
20130060052ORALLY DISPERSIBLE TABLET - The present invention provides a preparation with improved disintegration property, a preparation showing improved bioavailability of a medicament, production methods thereof and the like. A rapidly disintegrating preparation comprising granules comprising a medicament coated with a coating layer containing sugar or sugar alcohol; and a disintegrant. A production method of a rapidly disintegrating preparation including a step of producing granules comprising a medicament, a step of forming a coating layer containing sugar or sugar alcohol on the obtained granules and a step of mixing the coated granules with a disintegrant and molding the mixture.2013-03-07
20130060053SYNTHESIS OF LONG-CHAIN POLYUNSATURATED FATTY ACIDS BY RECOMBINANT CELL - The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids.2013-03-07
20130060054METHODS OF FORMING SINGLE SOURCE PRECURSORS, METHODS OF FORMING POLYMERIC SINGLE SOURCE PRECURSORS, AND SINGLE SOURCE PRECURSORS FORMED BY SUCH METHODS - Methods of forming single source precursors (SSPs) include forming intermediate products having the empirical formula ½{L2013-03-07
20130060055ORGANIC MOLYBDENUM COMPOUNDS AND LUBRICATING COMPOSITIONS WHICH CONTAIN SAID COMPOUNDS - Dicyclopentadienyl molybdenum crosslinked complexes which can be represented by general formula (2013-03-07
20130060056CATALYSTS, METHODS OF MAKING CATALYSTS, AND METHODS OF USE - Embodiments of the present disclosure provide for catalysts such as those shown in FIG. 2013-03-07
20130060057METHOD FOR PRODUCING ESTER-FUNCTIONAL SILANES - Silanes containing an ester group are produced in high yield and purity by reacting a salt of a carboxylic acid with a silane containing a carboxylate substitutable leaving group following by distilling the product mixture to obtain a distillate containing the ester group containing silane product, wherein a solvent having a boiling point higher than the product is contained in the product mixture during at least a terminal portion of the distillation.2013-03-07
20130060058METHOD FOR CONTINUOUS HYDROSILYLATION - The invention relates to a method for continuously producing silanes and/or organopolysiloxanes by hydrosilylation, in which at least one compound (A) containing at least one carbon-carbon multiple bond is reacted with at least one compound (B) comprising at least one Si—H functionality, wherein the reaction is carried out in a reaction mixing pump.2013-03-07
20130060059SYNTHESIS OF SILYL ACETYLENES - The present disclosure provides a method of preparing silylethynyl compounds in which two of the hydrocarbyl groups bonded to the silicon exclusive of the ethynyl group, are the same and one is different, that may be used in preparing novel silylethynyl functionalized acene semiconductor chromophores.2013-03-07
20130060060Preparation of Organohalosilanes - A process for preparing organohalosilanes comprising combining hydrogen, a halosilane having the formula H2013-03-07
20130060061Low-Impurity Organosilicon Product as Precursor for CVD - The present invention provides an organosilicon composition comprising diethoxymethylsilane, a concentration of dissolved residual chloride, and a concentration of dissolved residual chloride scavenger that does not yield unwanted chloride salt precipitate when combined with another composition comprising diethoxymethylsilane.2013-03-07
20130060062PROCESS FOR PREPARING ISOCYANATES - Process for preparing isocyanates by reacting the corresponding amines comprised in at least one feed stream A with phosgene comprised in at least one feed stream P in a reaction plant comprising at least one mixing zone and at least one reaction zone, wherein feed stream A and/or feed stream P optionally comprise one or more inert material s and,2013-03-07
20130060063METHOD FOR PRODUCING PRECURSORS FOR L-3,4-DIHYDROXY-6-[18F]FLUOROPHENYLALANINE AND 2-[18F]FLUORO-L-TYROSINE AND THE A-METHYLATED DERIVATIVES THEREOF, PRECURSOR, AND METHOD FOR PRODUCING L-3,4DIHYDROXY-6-[18F]FLUOROPHENYLALANINE AND 2-[18F]FLUORO-L-TYROSINE AND THE A-METHYLATED DERIVATIVES FROM THE PRECURSOR - Disclosed is a method for producing precursors for L-3,4-dihydroxy-6-[2013-03-07
20130060064METHOD AND SYNTHESIS - The present invention provides a method for the preparation of a radiolabeled guanidine derivative, in particular wherein the radiolabeled guanidine derivative is a positron emission tomography (PET) tracer. Certain intermediates useful in said method are also provided, as well as means for carrying out said method in an automated fashion. The method of the invention provides advantages over known methods for the preparation of radiolabeled guanidine derivatives.2013-03-07
20130060065Process for the Dehydration of Substituted 4-Dimethylamino-2-aryl-butan-2-ol Compounds and Process for the Preparation of Substituted Dimethyl-(3-aryl-butyl)- Amine Compounds by Heterogeneous Catalysis - Process for the preparation of substituted dimethyl-(3-aryl-butyl)-amine compounds. The process comprises dehydration by heterogeneous catalysis of substituted 4-dimethylamino-2-aryl-butan-2-ol compounds, to form substituted dimethyl-(3-aryl-but-3-enyl)-amine intermediates, which are then converted by hydrogenation with hydrogen to substituted dimethyl-(3-aryl-butyl)-amine compounds.2013-03-07
20130060066METHOD FOR ISOMERISATION OF HOP ALPHA-ACIDS USING HETEROGENEOUS ALKALINE EARTH METAL BASED CATALYSTS - The invention relates to a process for the production of iso-alpha-acids starting from hop alpha-acids in which an hop alpha-acid containing feed is contacted with a heterogeneous alkaline earth metal based catalyst, that essentially does not dissolve in the alpha-acid containing feed or in the iso-alpha-acid product phase, either in solvent-free conditions or in the presence of water, carbon dioxide, or an organic solvent or a mixture thereof. The resulting mixture is subjected to a temperature of at least 293 K, preferably under an inert atmosphere, for a time sufficient to effect high conversion of the alpha-acid reactant into the iso-alpha-acid product. The molar ratio of alpha-acid to earth alkaline metal (Mg, Ca, Sr, Ba) varies preferably between 0.2 and 20. After the isomerisation process, the heterogeneous alkaline earth metal based catalyst can be quantitatively separated from the iso-alpha-acid product phase by liquid-solid separation techniques.2013-03-07
20130060067NOVEL METHOD FOR THE CONVERSION OF CELLULOSE AND RELATED CARBOHYDRATE MATERIALS TO LOW-MOLECULAR-WEIGHT COMPOUNDS - Methods of converting cellulose or related biorenewable carbohydrate materials into high-value chemical compounds. The methods provide a means of converting low-cost materials such as cellulose and biomass into high yields of compounds such as ethylene glycol, propylene glycol, glycerin, methanol, hydroxyacetone, glycolaldehyde and dihydroxyacetone.2013-03-07
20130060068PROCESSES FOR THE PRODUCTION OF FLUOROPROPANES AND HALOPROPENES - A process is disclosed for making CF2013-03-07
20130060069DEHYDROFLUORINATION OF PENTAFLUOROALKANES TO FORM TETRAFLUOROOLEFINS - A method for producing a tetrafluoroolefin, such as 2,3,3,3-tetrafluoropropene (HFO-123434), comprises dehydrofluorinating a pentafluoroalkane in a gas phase in the presence of a catalyst comprising chromium oxyfluoride. In a preferred embodiment, 2,3,3,3-tetrafluoropropene (HFO-1234yf) is produced by forming a catalyst comprising chromium oxyfluoride by calcining CrF3?xH2O, where x is 1-10, in the presence of a flowing gas comprising nitrogen to form a calcined chromium oxyfluoride, and dehydrofluorinating 1,1,1,2,2-pentafluoropropane (HFC-245cb) in a gas phase in the presence of the catalyst to form the 2,3,3,3-tetrafluoropropene (HFO-1234yf).2013-03-07
20130060070METHOD FOR PRODUCING FLUID HYDROCARBONS - The invention relates to methods for producing fluid hydrocarbon products, and more specifically, to methods for producing fluid hydrocarbon product via catalytic pyrolysis. The reactants comprise solid hydrocarbonaceous materials, and hydrogen or a source of hydrogen (e.g., an alcohol). The products may include specific aromatic compounds (e.g., benzene, toluene, naphthalene, xylene, etc.).2013-03-07
20130060071PROCESS FOR THE CONVERSION OF LIGNIN TO LIQUID HYDROCARBONS - Process for the conversion of lignin to liquid hydro-carbons comprising: subjecting the lignin to hydrogenolysis in the presence of at least one hydrogenolysis catalyst, at a temperature ranging from 250° C. to 350° C., preferably ranging from 290° C. to 320 ° C., so as to obtain depolymerized lignin; subjecting said depolymerized lignin to hydrotreating so as to obtain a mixture of liquid hydrocarbons. Said liquid hydrocarbons can be used as such (biofuels) for the production of reformulated gasolines, or they can be used for the production of gasolines or of gas oils through conventional refining processes.2013-03-07
20130060072Processed Support and Methods of Making and Using Same - A method for removing tightly bound sodium from a zeolitic support comprising contacting the support with a sodium specific removal agent to produce a treated support. A method comprising providing an aromatization catalyst comprising a treated support, and contacting the aromatization catalyst with a hydrocarbon feed in a reaction zone under conditions suitable for the production of an aromatic product. A catalyst support comprising an L-zeolite having less than 0.35 wt. % sodium.2013-03-07
20130060073METHOD AND SYSTEM FOR PRODUCING LOW-OXYGENATE OLEFIN FLOWS - A process and a plant for producing an olefin stream from a hydrocarbon mixture feed stream, wherein the olefin stream is depleted as regards its content of oxygen-containing organic compounds (oxygenates) as compared to the feed stream. The hydrocarbon mixture feed stream is charged to a separation column operated by a thermal separation process, for example to a distillation column, wherein a material stream enriched in oxygenates is withdrawn via a side outlet and removed from the process. The process according to the invention is particularly useful for processing the product streams obtained in the olefin synthesis by an OTO process.2013-03-07
20130060074Method for Producing High Purity Biomethane Without Adding Unacceptable Quantities of Moisture - A method for producing high purity biomethane using two non-regenerative media in series to reliably and virtually completely eliminate undesirable impurities from biomethane. The first media in the series is activated carbon, preferably virgin media, produced from coconut shells or coal. The second media in the series is silica gel or other desiccant. Neither material is regenerated; rather, the purity of the biomethane is monitored and when the media is spent, the media is discarded.2013-03-07
20130060075METHOD AND APPARATUS FOR HOMOGENISING AND STABILISING AN IRON-BEARING RESIDUE - A method and apparatus for converting an iron-bearing residue generated in a hydrometallurgical process that contains small amounts of soluble heavy metals into a stable form by means of a neutralising agent. The residue is elutriated and the elutriated residue is fed into at least one stabilisation or homogenisation reactor, into which a neutralising agent is also routed, and the homogenous mixing together of the residue and neutralising agent takes place by means of a helix mixer, where the ratio of the diameter of the mixer to the diameter of the reactor is 0.75-0.99.2013-03-07
20130060076METHOD TO REDUCE PCB CONTENT AND/OR LEAD TCLP SOLUBILITY - This invention provides a method for the treatment of wastes and materials by addition of Amber Phosphoric Acid to reduce the PCB content and/or TCLP Pb content, thus allowing treated materials or waste to be classified as non-Toxic Substance Control Act (TSCA) waste and/or non-hazardous RCRA solid waste, or otherwise allowed to be reused or land filled at a cost lower than without such treatment.2013-03-07
20130060077PUMP ARRANGEMENT - The subject matter of the present invention is a pump arrangement (2013-03-07
20130060078BODILY IMPLANT WITH TENSION INDICATOR - A bodily implant is provided to support body tissues of a patient. The bodily implant includes a strip having a first portion and a second portion. The strip is configured to be stretched in a manner such that the second portion is stretched from a first length to a second length. The second portion of the strip is configured to maintain the second length. The strip is further configured to be disposed proximate to the patient's body tissues.2013-03-07
20130060079COMPOSITIONS AND METHODS FOR AUTOLOGOUS GERMLINE MITOCHONDRIAL ENERGY TRANSFER - Oogonial stem cell (OSC)-derived compositions, such as nuclear free cytoplasm or isolated mitochondria, and uses of OSC-derived compositions in autologous fertility-enhancing procedures are described.2013-03-07
20130060080Pelvic Implant Needle System and Method - Various embodiments of a trocar or needle system for use in inserting and deploying pelvic implants are provided. The needle device can include a solid or hollow shaft portion with a non-circular cross-section. A grip element can be provided to slide along a length of the needle shaft to further facilitate handling.2013-03-07
20130060082PROBE SHAPE DETECTION APPARATUS AND PROBE SHAPE DETECTION METHOD - A probe shape detection apparatus includes a magnetic field sensing section for sensing a magnetic field generated by an electromagnetic coil in a flexible probe, a movement speed calculation section for calculating a movement speed of the coil, a coordinate computation section for calculating three-dimensional coordinates of the coil based on the sensed magnetic field, a moving average coordinate calculation section for calculating moving average coordinates of the coil, a comparison section for comparing the calculated movement speed with a predetermined threshold, a coil coordinate setting section for setting one of the moving average coordinates and the three-dimensional coordinates calculated by the coordinate computation section as the three-dimensional coordinates of the coil, based on a comparison result of the calculated moving speed, and a signal processing section for generating a video signal to display a shape of the probe, based on the set three-dimensional coordinates of the coil.2013-03-07
20130060083ENDOSCOPIC INSERTION SECTION TIP AND ENDOSCOPE - A tip of an endoscopic insertion section includes a tip body having a forceps hole, and a cap covering the distal face of the tip body and having an opening corresponding to the forceps hole. Protrusions are provided between the distal face of the tip body and the opposite face of the cap that is opposite to the distal face, so that a specified space is formed between the distal face and the opposite face with the protrusions. In the space, at least a region around the forceps hole is filled with an adhesive so as to adhere the tip body and the tip cap together with no voids in the adhesive surrounding the forceps hole and thereby prevent disadvantages due to the entrance of a body fluid or a chemical cleaning solution through such voids.2013-03-07
20130060084ARRANGEMENT FOR MINIMAL ACCESS SURGERY - An access and positioning arrangement for use during an endoscopic surgical procedure in which a pair of surgical tools are utilized, such as an endoscopic imaging device for providing an image of the surgical site and a surgical instrument for manipulating tissue at the surgical site. The arrangement includes a housing for positioning over a surgical portal defined in the patient through which the surgical site is accessed, which housing defines first and second channels which receive the respective surgical tools so that the tools can be maintained in a fixed orientation relative to one another within the surgical site and so that the tools can be readily positioned in the correct positions relative to one another at the surgical site.2013-03-07
20130060085ENDOSCOPE CAPSULE FOR DETECTING THE THREE-DIMENSIONAL STRUCTURE OF THE INNER SURFACE OF A BODY CAVITY - In a method and a device to detect information about the three-dimensional structure of the inner surface of a body cavity (2013-03-07
20130060086IMAGING SENSOR PROVIDING IMPROVED VISUALIZATION FOR SURGICAL SCOPES - A system, apparatus and methods for providing a single use imaging device having improved viewing for sterile environments is disclosed and described. A single use high definition camera used for general purpose surgical procedures including, but not limited to: arthroscopic, laparoscopic, gynecologic, and urologic procedures, may comprise an imaging device that is a sterile and designed to ensure single use. The imaging device may further include a sensor located near the tip of a laparoscope and a view optimizing assembly.2013-03-07
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