| 10th week of 2013 patent applcation highlights part 43 |
| Patent application number | Title | Published |
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| 20130059684 | BELT TYPE CONTINUOUSLY VARIABLE TRANSMISSION - With respect to a belt type continuously variable transmission in which a belt is wound around between a primary pulley and a secondary pulley, each of which includes a stationary sheave and a movable sheave, and a transmission is carried out by forwardly and backwardly moving the movable sheave with respect to the stationary sheave, a boss portion that protrudes in an axial direction is integrally formed with the stationary sheave of the secondary pulley, and a parking gear is provided on the outer circumferential side of the boss portion. Further, the configuration to hold the bearing is achieved using the inner circumferential portion of the boss portion integrally formed with the stationary sheave, that is, the inner circumferential portion of the parking gear so as to shorten the axial length of the secondary shaft, whereby achieving cost reduction. | 2013-03-07 |
| 20130059685 | SELF-LUBRICATING TORQUE TRANSFER DEVICES - In some embodiments, a self-lubricating torque transfer device may include a shaft; a pulley body disposed about the shaft, the pulley body and shaft rotatable with respect to each other in a first direction by at least a first angular displacement and in an opposing second direction by at least a second angular displacement; each of the pulley body and shaft having engagement features that engage upon sufficient rotation between the pulley body and the shaft, wherein the engagement features, when engaged, prevent further rotation between the pulley body and the shaft in a given direction; and a resilient member disposed between the pulley body and the shaft, wherein the resilient member is compressed between the engagement features of the pulley body and the shaft upon sufficient rotation between the pulley body and the shaft, wherein the resilient member comprises a resilient material and a lubricating agent. | 2013-03-07 |
| 20130059686 | TENSIONING MECHANISM FOR A CONTINUOUS BELT OR CHAIN DRIVE SYSTEM - An apparatus ( | 2013-03-07 |
| 20130059687 | MECHANICAL TENSIONER WITH ONE WAY DAMPING - An apparatus for imparting tension to multiple strands of an endless loop power transferring member encircling a drive sprocket and at least one driven sprocket. A tensioner mechanism includes a slider assembly having a fixed body defining a slot, a slider body engaged within the slot for movement between opposite ends of the slot, and a spring urges the slider body toward one end of the slot. The slider body is operably engageable with at least one tensioning arm for driving the at least one tensioning arm to tension the power transferring member. A link assembly can include two link members pivotally connected to the slider body at first ends and individually connected at second ends to two tensioning arms. | 2013-03-07 |
| 20130059688 | TRANSMISSION GUIDE - A transmission guide comprises a synthetic resin shoe and a more rigid synthetic resin base, integrally molded by two-member molding. The base is formed with a pair of spaced, opposed, side walls extending in the direction of elongation of the base along opposite edges of a shoe-supporting surface of the base. These side walls engage respective side edges of the shoe, and extend past the front surface of the shoe so that they can restrict lateral movement of a transmission chain sliding along the front surface of the shoe. Indentations in the side walls receive protrusions formed on the edges of the shoe. Edges of the openings of the indentations are chamfered or convexly curved to avoid interference with the movement of the chain along the guide. | 2013-03-07 |
| 20130059689 | CUSHIONING STRUCTURE FOR A SPROCKET - To reduce operating noise and further improve durability in a cushioning structure for a sprocket used in a roller chain or bush chain. MEANS OF RESOLUTION Annular first and second cushion rings | 2013-03-07 |
| 20130059690 | High Performance Toothed Belt - A toothed belt is described, comprising resistant inserts that each have a total diameter, indicated by φtot, in the range between 0.9 and 3 mm. The resistant insert consist of a core consisting of at least one yarn of fibres of a first material having a diameter φc and a number N of cover yarns of fibres of a second material. The number of cover yarns N is in the range between 10 and 25 and the N yarns entirely surround the core, moreover the ratios between the total diameter of the resistant insert and the core diameter are in the range 0.4| 2013-03-07 | |
| 20130059691 | SILENT CHAIN - In a silent chain, frictional losses and noise are reduced, and power transmitting efficiency is improved, by making the inner profile of each guide plate sufficiently high in relation to a link plate tooth of a link plate overlapped by each said guide plate that engagement between a sprocket tooth and said link plate tooth takes place before engagement of the last mentioned sprocket tooth with said guide plate, even when the chain moves laterally. The tensile hardness of the guide plates is sufficiently low in relation to the bending rigidity of the connecting pins of the chain to prevent substantial warping of the guide plates as a result of tension acting on the chain. The back surfaces of the guide plates are configured to avoid contact with a sliding contact surface of a chain guide on which a back surfaces of the link plates of said chain can slide. | 2013-03-07 |
| 20130059692 | MECHANICAL SPEED VARIATOR WITH ECCENTRIC DYNAMIC MASSES HAVING A BALANCED STRUCTURE - A mechanical speed variator is provided with eccentric masses having a balanced structure. The variator includes a drive shaft, provided with a cam composed of a circular disk eccentrically mounted on the drive shaft, which drives the driven shaft in rotation with interposition of a series of eccentric masses, each of them being composed of a circular disk with eccentric circular hole in which another mass of lower dimensions is ratably housed. The larger mass is housed and rotates inside the eccentric hole of a ring coupled with bolts to a flange and counter flange, respectively mounted on the driven shaft and the drive shaft. | 2013-03-07 |
| 20130059693 | High Efficient and High Power Plane Centric Gear Unit - A plane centric gear unit has a circumferentially floating ring gear | 2013-03-07 |
| 20130059694 | SUPPORTING STRUCTURE FOR PLANETARY GEAR MECHANISM - A supporting structure for a planetary gear mechanism includes a planetary carrier, a first bearing, and a second bearing. The planetary carrier includes a rotation shaft and an arm portion. The rotation shaft extends in an axis direction to support a planetary gear of the planetary gear mechanism to be rotatable about a rotational axis along the axis direction. The rotation shaft includes a first end and a second end opposite to the first end along the rotational axis. The first and second bearings are disposed on a first side of the planetary gear in the axis direction. The planetary carrier is radially supported by the first and second bearings without a bearing which radially supports the planetary carrier in the casing and which is provided on a second side of the planetary gear in the axis direction. | 2013-03-07 |
| 20130059695 | DRIVING FORCE TRANSMISSION DEVICE - A hybrid driving force transmission device includes an engine (E), a motor-clutch unit (MC), and a transmission unit (T). The motor-clutch unit (MC) is coupled to the engine (E), and includes a multi-plate dry clutch ( | 2013-03-07 |
| 20130059696 | EXERCISE SYSTEM AND CONTROLLER - The invention relates to an exercise system/device for exercising a user's upper limb. The exercise system/device is intended for use in rehabilitating patients suffering hemiparesis that causes one upper limb to be at least partially paralysed. For example, the exercise system/device can be used for neuroplastic retraining rehabilitation techniques for enabling patients to regain control of their paralysed upper extremities, including shoulders, elbows, wrists and fingers, but primarily their shoulders and elbows via larger arm movements. This is achieved through the use of an elongate handle and a motion sensing device associated with the handle for communicating the user's movements of the A handle to a gaming system. Although the exercise system/device is primarily for rehabilitation of patients suffering hemiparesis, it will be appreciated that it may also be used by any person for bilateral training and exercising upper limbs. | 2013-03-07 |
| 20130059697 | Oblong Orbital Exercising Machine Having Adjustable Trace of Movement - An exercising machine includes a main frame, an upright post mounted on the main frame, two swinging handles pivotally connected with the upright post, a cycle movement mechanism mounted on the main frame, two pivot members mounted on the cycle movement mechanism, two links each pivotally connected with the respective swinging handle and the respective pivot member, two pedals mounted on the links, and two adjusting members each pivotally mounted between the respective link and the respective pivot member and each provided with a plurality of adjusting holes. Thus, each of the links is pivotally connected with one of the adjusting holes of the respective adjusting member to change the position and angle of each of the links and each of the swinging handles so as to adjust the movement trace of each of the links. | 2013-03-07 |
| 20130059698 | System and Method for Simulating Environmental Conditions on an Exercise Bicycle - A stationary exercise cycle includes a simulation system for simulating real-world terrain based on environmental and other real-world conditions. Using topographical or other data, an actual location can be simulated. The exercise cycle may include a resistance mechanism that is adjusted based on changes in simulated slope, and by amounts simulating actual frictional and gravitational forces. The simulated speed of the rider, as well as speed and direction of a simulated wind, are used to determine a simulated air speed. Based on the simulated air speed, the simulation system determines the simulated air resistance hindering the rider, and changes reflective of the simulated air resistance are made by the resistance mechanism. The stationary exercise cycle takes into account actual or approximate physical information of the user in determining the real-world conditions that are simulated, including the height, weight, shape, and/or rising position of the rider. | 2013-03-07 |
| 20130059699 | TRAINING STAND - A nestable training stand is provided. The stand includes a central frame member having upper and lower portions; and a base operatively coupled to the lower portion. The base comprises a U-shaped or V-shaped base member having first and second end portions; and a support member connected to and extending upwardly from the first and second end portions to the central frame member. One or more upper and/or lower weight support pins are coupled to the support member and central frame, respectively, and extend outward for holding weights to prevent the stand from moving. The central frame support may include a bend between a first point where it couples to the U-shaped or V-shaped base member and a second point where it couples to support member to shift the center of gravity of the stand backwards. | 2013-03-07 |
| 20130059700 | BASKETBALL TRAINER FOR DEVELOPING GRIPPING STRENGTH AND POWER - A training device | 2013-03-07 |
| 20130059701 | Multi-functional hand held exercise device - A hand held exercise device that is ergonomically friendly, is usable for any type of exercise of user choice. The device is most versatile and more importantly allows for complete smooth rolling motion. The overall unusual results are achieved because of the construction and inclusion of a partial sphere shaped bottom section. This novel feature allows for side to side tilting and/or vertical and horizontal movement simultaneously. Also the device includes numerous accessory optional features of choice. | 2013-03-07 |
| 20130059702 | Stretch Strap - The present invention provides in some embodiments, a device for stretching muscles having a series of loops. The device can be formed from strips of elastic material periodically joined in order to form loops. More particularly, a top portion of elastic material can be laid on top of a bottom portion of elastic material. The top and bottom portions of materials can be joined in a variety of ways. A user of the device can engage different body parts with the loops and use the device to facilitate a dynamic stretch of a muscle. Dynamic stretching involves active contraction of the muscle prior to the stretch. | 2013-03-07 |
| 20130059703 | Exercise System - An exercise system for conducting complete body range of motion exercises having a base restable on a surface. A vertical support is mounted to the base. A rear support is attached between the base and the vertical support. At least one lower resistance device is slidably secured to the rear support. A lower resistance band is attached to the lower resistance device with a handle on each end. A back support is mounted to the vertical support. A chest support is mounted above the abdominal support. A head support is mounted to the vertical support with an upper resistance device mounted below the head support. An upper resistance band is attached to the upper resistance device with a handle on each end. A pair of arms extends from the vertical support. The resistance bands provide resistance to the user thereby toning and strengthening user's body improving both posture and range of motion. | 2013-03-07 |
| 20130059704 | Method and Device for Training Athletes to Stay Low - The invention is a method and device for training athletes to stay low. The device utilizes a series of belts, adjustable straps and foot ankle braces removably attached to each other via magnet connections so that when an athlete rises too far from the court, the straps disengage from the foot-ankle braces at the magnetic connection alerting both the athlete and the coach that the player is no longer staying low and has risen upward. The device facilitates several drills that teach the athletes to stay low during predefined sporting conditions. | 2013-03-07 |
| 20130059705 | Tilting inversion exerciser - A tilting inversion exerciser includes a carrier pivotally attached to a supporting stand for mounting a supporting table and for supporting a user, and a support member is engaged with the supporting table and curved upwardly from the supporting table for selectively engaging with a waist portion of the user and for supporting and massaging the waist portion of the user. The support member includes a latch element extended from each side for engaging with the supporting table and for anchoring and securing the support member to the supporting table, and the supporting table includes a number of slots and channels for engaging with the latch elements of the support member and for adjusting a curvature of the support member relative to the supporting table. | 2013-03-07 |
| 20130059706 | Massage device for tilting inversion exerciser - A tilting inversion exerciser includes a carrier pivotally attached to a supporting stand for mounting a supporting table and for supporting a user, the supporting table includes a number of grooves, and a massage member is engaged with either of the grooves of the supporting table for attaching to the supporting table and for selectively engaging with the user to selectively massage the user. The massage member includes a catch engageable through the grooves of the supporting table for attaching to the supporting table, the catch is coupled to the massage member with a reduced neck member. The catch includes a length (L) greater than the width (D) of the grooves of the supporting table for engaging with the supporting table. | 2013-03-07 |
| 20130059707 | MACHINE FOR PRODUCING CARDBOARD CUTOUTS - The invention relates to a machine for producing cardboard cutouts, comprising a magazine ( | 2013-03-07 |
| 20130059708 | Method and Apparatus For Making Bag Using Ultrasonic Sealing - A method and apparatus for making bags or pouches is disclosed. An ultrasonic sealer may be used to form the seals. Sealing patterns may be used to provide a desired strength profile. | 2013-03-07 |
| 20130059709 | BAG MAKING AND PACKAGING MACHINE - A bag making and packaging machine forms a first transverse seal portion in a packaging material formed in a tubular shape, fills the packaging material with articles, thereafter further forms a second transverse seal portion to make a bag, and allows the bag to fall, and is equipped with a vibrating mechanism. The first transverse seal portion is formed in a direction perpendicular to a conveyance direction of the packaging material. The vibrating mechanism tilts the packaging material to an outer side of a fall path of the bag and vibrates the packaging material after the packaging material has been filled with the articles and before the second transverse seal portion is formed. | 2013-03-07 |
| 20130059710 | HEAT SEAL BAR MOUNTING APPARATUS OF PLASTIC BAG MAKING MACHINE - It is intended to mount and remove the heat seal bar | 2013-03-07 |
| 20130059711 | Method For Inserting A First Folded Film Within A Second Folded Film - Methods for inserting a folded film into another folded film include combining the films without unfolding or folding either of the folded films. In particular, one or more implementations of a method of combining folded films involves directing a first folded film in a first direction and separating first and second halves of the first folded film. The method also involves directing a second folded film in a second direction generally perpendicular to the first direction. Additionally, the method involves inserting the second folded film between the first and second halves of the first folded film. Furthermore, the method involves redirecting the second folded film into the first direction while between the first and second halves of the first folded film. | 2013-03-07 |
| 20130059712 | Apparatus For Inserting A First Folded Film Within A Second C-Folded Film - Apparatus for inserting a folded film into another folded film include combining the films without unfolding or folding either of the folded films. In particular, one or more implementations include a spreader bar configured to separate layers of a first folded film. Additionally, the apparatus can include one or more orientation rollers configured to direct a second film between the separated layers of the first folded film. Furthermore, the apparatus can include a direction change bar configured to change the direction a travel of the second film while the second film is positioned between the layers of the first folded film. | 2013-03-07 |
| 20130059713 | ABSORBENT-BODY MANUFACTURING APPARATUS - An absorbent-body manufacturing apparatus manufactures an absorbent body by depositing absorbent-body material in a plurality of recess sections spaced at an arrangement pitch on an outer circumferential face of a drum. The apparatus has a driving source that drives the drum in synchronization with another apparatus based on a synchronization signal. First and second signal-generating sections repeatedly generate first and second rotational-angle signals based on a rotation of the drum with a rotational angle of the drum as a unit, the rotational angle of the drum corresponding to first and second pitches, respectively. Depending on whether the arrangement pitch is set to the first or second pitch, a controller controls rotational driving operation of the driving source based on the first or second rotational-angle signal and on the synchronization signal. | 2013-03-07 |
| 20130059714 | CONTINUOUS WEB PROCESSING DEVICE - A folding unit extends in the MD | 2013-03-07 |
| 20130059715 | Apparatus and Method for Folding Film Edges - Pre-stretched films may be used to increase the rate at which loads can be wrapped and to minimize the exertion required when using traditional handheld film. However, the edges of pre-stretched films are easily damaged, which may result in tearing or failure of the film during use. The present disclosure describes devices, systems, and methods for folding the edges of the film, resulting in a film that is less susceptible to damage and easier to use. | 2013-03-07 |
| 20130059716 | ALUMINO-SILICATE GLASS HAVING HIGH THERMAL STABILITY AND LOW PROCESSING TEMPERATURE - The invention relates to an alumino-silicate glass which has a thermal expansion coefficient in the range of 8 to 10×10 | 2013-03-07 |
| 20130059717 | Method of strengthening glass by plasma induced ion exchanges in connection with tin baths, and articles made according to the same - Certain example embodiments relate to an improved method of strengthening glass substrates (e.g., soda lime silica glass substrates). In certain examples, a glass substrate may be chemically strengthened by creating an electric field within the glass. In certain cases, the chemical tempering may be performed by surrounding the substrate by a plasma including certain ions, such as Li | 2013-03-07 |
| 20130059718 | GLASS SUBSTRATE FOR FLAT PANEL DISPLAY AND METHOD FOR MANUFACTURING SAME - A substrate for p-Si TFT flat panel displays made of a glass having a high low-temperature-viscosity characteristic temperature and manufactured while avoiding erosion/wear of a melting tank during melting through direct electrical heating. The glass substrate comprises 52-78 mass % of SiO | 2013-03-07 |
| 20130059719 | Aluminum oxycarbide composition, production method therefor, and refractory material - It is an object to provide an aluminum oxycarbide composition capable of suppressing oxidation of Al | 2013-03-07 |
| 20130059720 | SILICON CARBIDE FIBER DISPERSION-REINFORCED COMPOSITE REFRACTORY MOLDING - A silicon carbide fiber dispersion-reinforced composite refractory molding includes an aggregate part and a bonding part which are obtained by compounding an plastic refractory composition containing at least SiC, with SiC fiber chops, in an amount of 0.1 to 3% by weight based on the plastic refractory composition, wherein fiber bundles each including a plurality of SiC inorganic fibers containing 50% or more SiC in their main component and having a length of 10 mm to 100 mm and a fiber diameter of 5 μm to 25 μm were bundled via an organic binder, kneading the mixture with water and then drying and solidifying it, wherein monofilaments including SiC inorganic fibers containing 50% or more SiC, having a fiber diameter of 5 μm to 25 μm, a fiber length of 50 μm to 2,000 μm and an aspect ratio of 5 to 200 are dispersed in the bonding part. | 2013-03-07 |
| 20130059721 | SUPERHARD ELEMENT, METHOD OF USING SAME AND METHOD OF MAKING SAME - A superhard element ( | 2013-03-07 |
| 20130059722 | ONE-STEP SYNTHESIS OF MESOPOROUS PENTASIL ZEOLITE WITH SINGLE-UNIT-CELL LAMELLAR STRUCTURAL FEATURES - A method for making a pentasil zeolite material includes forming an aqueous solution that includes a structure directing agent and a silica precursor; and heating the solution at a sufficient temperature and for sufficient time to form a pentasil zeolite material from the silica precursor, wherein the structure directing agent includes a quaternary phosphonium ion. | 2013-03-07 |
| 20130059723 | Synthesis of Zeolitic Materials using N,N-Dimethyl Organotemplates - The present invention relates to a process for the preparation of a zeolitic material having a structure comprising YO | 2013-03-07 |
| 20130059724 | HONEYCOMB STRUCTURE AND HONEYCOMB CATALYST BODY - Partition walls are provided with small pores and large pores, a porosity of the partition walls is from 50 to 70%, a porosity of the large pores of the partition walls is 30% or larger, a ratio of a total volume of the small pores to a total volume of the large pores is 20% or larger, and in a graph showing a pore diameter distribution of the partition walls, the pore diameter at a maximum peak value of the large pores is from 20 to 200 μm, and the pore diameter at a maximum peak value of the small pores is from 0.1 to 8 μm. Furthermore, a value obtained by dividing a porosity value (%) of the large pores by a thickness value (μm) of the partition walls is 0.2 or larger in a honeycomb structure. | 2013-03-07 |
| 20130059725 | Metallic Alloys with Microbiological Component and Catalytic Properties - This invention concerns a new material with enhanced catalytic properties, produced by mechanical alloying of microbially encapsulated metallic (or zerovalent) nanoparticles with a second metallic component. The bioencapsulation ensures a maximized contact area for molecular restructuring, since the microbial biomass can prevent agglomeration during the mechanical alloying process. The resulting product is a metallic alloy with at least 1% of the material dry weight comprising microbial biomass and with enhanced catalytic properties. | 2013-03-07 |
| 20130059726 | THERMAL IMAGING MEMBERS AND METHODS - There are described thermal imaging members and thermal imaging methods utilizing unsymmetrical rhodamine compounds. The rhodamine color-forming compounds exhibit a first color when in a crystalline form and a second color, different from the first color, when in an amorphous form. | 2013-03-07 |
| 20130059727 | REVERSIBLE THERMOSENSITIVE RECORDING MEDIUM - To provide a reversible thermosensitive recording medium, which contains: a base; and a reversible thermosensitive recording layer disposed on the base, wherein the base contains a first support, an electronic information recording module, an adhesive covering the first support, and a second support in a surface of which a groove is formed as a laser mark by laser marking, and wherein a ratio of a maximum depth A to a total thickness of the reversible thermosensitive recording medium is 20% or less, where the maximum depth A is a length from the surface of the second support to a bottom of the groove of the laser mark with respect to a thickness direction of the reversible thermosensitive recording medium. | 2013-03-07 |
| 20130059728 | THERMOSENSITIVE RECORDING MEDIUM - A thermosensitive recording medium having excellent image quality and surface strength is provided. The thermosensitive recording medium having excellent image quality and surface strength is obtained by containing a saturated fatty acid amide in the substrate to lower the density of the substrate. The thermosensitive recording medium of the present invention has an adequate general printability and problems such as print through are avoided. Furthermore, the thermosensitive recording medium of the present invention can assure adequate image quality and general printability even when an undercoat layer is not installed. | 2013-03-07 |
| 20130059729 | STREPTOMYCES BETA-VULGARIS STRAIN, CULTURE FILTRATE, DERIVED ACTIVE COMPOUNDS AND USE THEREOF IN THE TREATMENT OF PLANTS - A method of stimulating the natural defense system of a plant utilizing an isolated strain of | 2013-03-07 |
| 20130059730 | INSECTICIDAL COMBINATION - A method of controlling or preventing damage to a plant, which comprises applying to the plant, part of a plant, plant organ, and/or plant propagation material thereof, or surrounding area thereof a combination comprising (I) abamectin, and (II) etoxazole, in any desired sequence or simultaneously. | 2013-03-07 |
| 20130059731 | NOVEL SOLID FORM OF 4-[[(6-CHLOROPYRIDIN-3-YL)METHYL](2,2-DIFLUOROETHYL)AMINO]FURAN-2(5H)-ONE - The present invention relates to a novel solid form of 4-[[(6-chloropyridin-3-yl)methyl](2,2-difluoroethyl)amino]furan-2(5H)-one, to processes for its preparation and to its use in agrochemical preparations. | 2013-03-07 |
| 20130059732 | AAV CAPSID PROTEINS FOR NUCLEIC ACID TRANSFER - Recombinant adeno-associated viral (AAV) capsid proteins are provided. Methods for generating the recombinant adeno-associated viral capsid proteins and a library from which the capsids are selected are also provided. | 2013-03-07 |
| 20130059733 | MOLECULAR TESTING OF MULTIPLE PREGNANCIES - Methods, systems, and apparatus are provided for determining zygosity of a multiple-fetus pregnancy using a biological sample taken from the mother. The fetal and maternal DNA in the sample (e.g. plasma) can be analyzed for a particular chromosomal region to identify genetic differences in the fetuses. For example, a normalized parameter for the measure of a primary or secondary allele can show variances for different chromosomal regions when fetuses are dizygotic. Such a variance can be determined relative to an expected value if the fetuses were genetically identical. Statistical methods are provided for analyzing the variation of the normalized parameters to determine fetal DNA concentration and the maternal-fetal mixed genotype at various loci. Parental genotype and haplotype information can also be used to identify inheritance of different parental haplotypes to indicate genetic differences among the fetuses. | 2013-03-07 |
| 20130059734 | Epigenetic analysis - Provided herein are methods for the analysis of methylation in nucleic acid molecules, comprising bisulfite conversion and subsequent copying or amplification in the presence of a ligand-labelled dCTP or a ligand-labelled dGTP incorporated at the site of a cytosine or complementary guanine, respectively, at positions corresponding to methylated cytosines in the bisulfite-treated nucleic acid or after the copying or amplification, subjecting the resulting nucleic acid molecules to restriction endonuclease digestion with an enzyme which comprises a cytosine nucleotide in its target recognition sequence to generate nucleic acid fragments with termini proximal or adjacent to one or more cytosines and attaching a ligand or oligonucleotide adaptor and subsequently amplifying the nucleic acid molecules. | 2013-03-07 |
| 20130059735 | METHODS FOR MULTIPLEX AMPLIFICATION - Methods for multiplex amplification of target nucleic acid sequences are provided. | 2013-03-07 |
| 20130059736 | METHODS AND COMPOSITIONS FOR PROFILING RNA MOLECULES - Disclosed are compositions and methods for detecting target RNA molecules. A specialized DNA probe can be used to form RNA/DNA hybrids with target RNA molecules. Separation of the RNA/DNA hybrids increases the ease and sensitivity of detection and quantitation of the target RNA molecules. | 2013-03-07 |
| 20130059737 | EFFICIENT SHOTGUN SEQUENCING METHODS - Methods are provided for efficient shotgun sequencing to allow efficient selection and sequencing of nucleic acids of interest contained in a library. The nucleic acids of interest can be defined any time before or after preparation of the library. One example of nucleic acids of interest is missing or low confidence genome sequences resulting from an initial sequencing procedure. Other nucleic acids of interest include subsets of genomic DNA, RNA or cDNAs (exons, genes, gene sets, transciptomes). By designing an efficient (simple to implement, speedy, high specificity, low cost) selection procedure, a more complete sequence is achieved with less effort than by using highly redundant shotgun sequencing in an initial sequencing procedure | 2013-03-07 |
| 20130059738 | METHODS AND COMPOSITIONS FOR MULTIPLEX PCR - The present invention provides methods, compositions, kits, systems and apparatus that are useful for determining copy number variation of one or more nucleic acids present in a sample. In some aspects, the method includes various target-specific primers that allow for the selective amplification of one or more target nucleic acids in the sample. In yet another aspect, the invention relates to determining copy number variation with respect to gene or chromosome representation of a nucleic acid in the sample. In some aspects, the method for determining copy number variation of different target nucleic acids in a sample using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including diagnosis, predictive therapeutic regimes or other therapeutic purposes. | 2013-03-07 |
| 20130059739 | METHOD FOR HIGH-THROUGHPUT AFLP-BASED POLYMORPHISM DETECTION - The invention relates to a method for the high throughput discovery, detection and genotyping of one or more genetic markers in one or more samples, comprising the steps of restriction endonuclease digest of DNA, adaptor-ligation, optional pre-amplification, selective amplification, pooling of the amplified products, sequencing the libraries with sufficient redundancy, clustering followed by identification of the genetic markers within the library and/or between libraries and determination of (co-)dominant genotypes of the genetic markers. | 2013-03-07 |
| 20130059740 | Sequencing Small Amounts of Complex Nucleic Acids - The present invention provides methods and compositions for sequencing small amounts of complex nucleic acids such as human genomes and for analyzing the resulting sequence information in order to reduce sequencing errors and perform haplotype phasing, for example. | 2013-03-07 |
| 20130059741 | BINDING ASSAYS FOR MARKERS - This invention provides compositions and methods for assaying the presence of a target analyte in a sample using a solid support. Embodiments of the present invention provide a solid support having a binding protein, such as an antibody, antibody fragment or protein receptor, immobilized to the solid support and at least two separate nucleic acid primers immobilized near the binding protein. This invention also provides a method for tethering two or more polypeptide subunits to generate a multifunctional fusion protein, which can have a primary function, e.g., binding a target analyte, such as a target protein, or an enzymatic activity, and one or more of the subunits of the fusion protein carries out a secondary function, e.g., capture on a solid matrix or quantitation. | 2013-03-07 |
| 20130059742 | GLOBAL ANALYSIS OF SERUM MICRO RNAS AS POTENTIAL BIOMARKERS FOR LUNG ADENOCARCINOMA - A diagnostic kit to detect lung adenocarcinoma, or to stratify patients according to expected prognosis comprising at least one oligonucleotide probe capable of binding to at least a portion of a circulating miRNA selected from the group comprising miR-556, -550, -939, -616*, 146b-3p and -30c-1* biomarkers. | 2013-03-07 |
| 20130059743 | METHODS AND MICROARRAYS COMPATIBLE WITH DUAL FUNCTIONALITY OPTICAL DRIVES - A microarray with optically recorded information and a sample capable of producing a signal as a response to external influence, or a precursor which, when activated or combined with a reagent, produces a sample capable of generating a signal. The microarray is compatible with a dual functionality optical drive. A method for acquiring information about a sample comprises directing a probe to a sample at a microarray to produce a signal from the sample, wherein the microarray is compatible with a dual functionality optical drive, and detecting the signal. The information optically recorded on the microarray can be in the CD, DVD or HD DVD or Blue Ray format. | 2013-03-07 |
| 20130059744 | METHOD FOR EARLY DETECTION OF CANCER - The present inventors have demonstrated that circulating auto-antibodies to cancer antigens hold promise as specific and sensitive biomarkers for the early detection of cancer. The present invention thus relates to methods of detecting cancer in a sample, comprising utilising a glycopeptide bait derived from human mucins with different cancer-associated O-glycans. Detected antibodies were demonstrated as glycopeptide specific, and it could be discriminated between e.g. colorectal cancer patients and healthy individuals. The inventors have also developed monoclonal antibodies based on the identified glycopeptides epitope baits, and demonstrated differential expression of the relevant target antigens. The invention thus, in a lock and key-based manner includes both glycopeptides and antibody tools for early detection of cancer, as well as methods of using the same for in situ visualisation and treatment of specific cancer types. | 2013-03-07 |
| 20130059745 | METHODS AND USES RELATING TO THE IDENTIFICATION OF COMPOUND INVOLVED IN PAIN AS WELL AS METHODS OF DIAGNOSING ALGESIA - The present invention relates to a method of identifying a compound involved in pain, the use of Il2rg nucleic acid or Il2rg protein for identifying a compound involved in pain as well as methods of diagnosing algesia involving the same. | 2013-03-07 |
| 20130059746 | GENE EXPRESSION PROFILING OF CYTOGENETIC ABNORMALITIES - Provided herein are methods of predicting cytogenetic abnormalities associated with a cancer in a subject, for example, multiple myeloma. A cytogenetic abnormalities model of a set of reference values obtained from an average of gene expression profile values based on copy number-sensitive genes that correlate to cytogenetic abnormalities associated with the cancer is utilized as a predictive tool. The cytogenetic abnormalities model, as a virtual model (i.e. a “virtual karyotype”), may be tangibly stored with program instructions to implement the model in a computer system. In particular embodiments, the methods and systems provided by the invention operate without FISH (fluorescent in situ hybridization). | 2013-03-07 |
| 20130059747 | MULTIGENE PROGNOSTIC ASSAY FOR LUNG CANCER - The present invention provides methods for providing a prognosis for lung cancer using a panel of eleven molecular markers that includes BAG1, BRCA1, CDC6, CDK2AP1, ERBB3, FUT3, IL11, LCK, RND3, SH3BGR, and WNT3A, which are differentially expressed in lung cancer. The eleven markers are related to patient prognosis to 5-year overall survival outcomes, and are particularly useful in providing a prognosis for non-squamous NSCLC. | 2013-03-07 |
| 20130059748 | OPTIMIZED PROBES AND PRIMERS AND METHODS OF USING SAME FOR THE BINDING, DETECTION, DIFFERENTIATION, ISOLATION AND SEQUENCING OF INFLUENZA A; INFLUENZA B AND RESPIRATORY SYNCYTIAL VIRUS - Described herein are primers and probes useful for the binding, detecting, differentiating, isolating, and sequencing of influenza A, influenza B and RSV viruses. | 2013-03-07 |
| 20130059749 | METHOD FOR PREDICTING THE RESPONSE OF A SUBJECT SUFFERING FROM A VIRAL INFECTION OF THE LIVER TO AN ANTIVIRAL THERAPY - The application relates to treatments for improving antiviral therapies and to method for determining whether or not antiviral therapies will be effective. In particular, the present application provides a method for determining the likelihood that a subject having a viral infection of the liver will be responsive to antiviral therapy that includes stimulation of Interferon (IFN) activity, and kits for the performance of said determination. | 2013-03-07 |
| 20130059750 | BIOMARKERS - The invention relates to a method of diagnosing or monitoring schizophrenia or other psychotic disorder. | 2013-03-07 |
| 20130059751 | GENE FAMILY (LBFL313) ASSOCIATED WITH PANCREATIC CANCER - The invention relates generally to the changes in gene expression in human pancreatic adenocarcinoma. The invention relates specifically to a human gene family which is differentially expressed in cancerous pancreatic tissues compared to corresponding non-cancerous pancreatic tissues. | 2013-03-07 |
| 20130059752 | Compositions and methods for the treatment of immune related diseases - The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases. | 2013-03-07 |
| 20130059753 | Global Analysis of Serum microRNAs as Potential Biomarkers for Lung Adenocarcinoma - A diagnostic kit to detect lung adenocarcinoma, or to stratify patients according to expected prognosis comprising at least one oligonucleotide probe capable of binding to at least a portion of a circulating miRNA selected from the group comprising miR-556, -550, -939, -616*, -146b-3p, -30c-1*, -339-5p and -656. | 2013-03-07 |
| 20130059754 | DIGITAL ASSAYS WITH REDUCED MEASUREMENT UNCERTAINTY - The present disclosure provides a digital assay system, includes methods and apparatus, with reduced measurement uncertainty. In an exemplary method, an expected value for a measure that is a function of a level of a first target and a level of a second target in a sample may be provided. An optimal concentration for the first target may be obtained based on the expected value. An experimental value for the measure may be determined from a digital assay with partitions formed according to the optimal concentration. | 2013-03-07 |
| 20130059755 | Gene Based Prediction of PSA Recurrence for Clinically Localized Prostate Cancer Patients - Disclosed are methods, devices and kits for determining the likelihood of recurrence of prostate cancer using the expression levels of preferably three-gene classifier. The methods, devices and kits can be used independent of many nomograms currently in use or to improve the overall performance of such nomograms. | 2013-03-07 |
| 20130059756 | PRIMER SET FOR PCR, PEACTION LIQUID FOR PCR, AND METHOD FOR DETECTING FOOD POISONING BACTERIA - Nucleic acid of two or more types of food poisoning bacteria among | 2013-03-07 |
| 20130059757 | Novel Gene Targets Associated with Amyotrophic Lateral Sclerosis and Methods of Use Thereof - Compositions and methods for diagnosis and treatment of ALS are provided. | 2013-03-07 |
| 20130059758 | Detection, Staging and Grading of Benign and Malignant Tumors - The present invention provides a method for detecting and grading benign and malignant tumors using at least one sensor of conductive nanoparticles capped with an organic coating in conjunction with a learning and pattern recognition algorithm. The method utilizes a plurality of response induced parameters to obtain improved sensitivity and selectivity for diagnosis, prognosis, monitoring and staging various types of cancers, or for identifying or grading benign or malignant tumors. | 2013-03-07 |
| 20130059759 | REVERSE TRANSCRIPTION PRIMERS AND METHODS OF DESIGN - The present invention provides novel algorithms for designing oligonucleotides that do not substantially hybridize to a small group of unwanted transcripts, while hybridizing to most other transcripts. Such oligonucleotides are particularly useful as primers for reverse transcription. The invention also provides compositions containing oligonucleotides that do not substantially hybridize to a small group of unwanted transcripts, while hybridizing to most other transcripts. | 2013-03-07 |
| 20130059760 | siRNA Targeting Fructose-1, 6-bisphosphatase 1 (FBP1) - Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for FBP1. | 2013-03-07 |
| 20130059761 | Assembly of High Fidelity Polynucleotides - Methods and apparatus relate to the synthesis of high fidelity polynucleotides and to the reduction of sequence errors generated during synthesis of nucleic acids on a solid support. Specifically, design of support-bound template oligonucleotides is disclosed. Assembly methods include cycles of annealing, stringent wash and extension of polynucleotides comprising a sequence region complementary to immobilized template oligonucleotides. The error free synthetic nucleic acids generated therefrom can be used for a variety of applications, including synthesis of biofuels and value-added pharmaceutical products. | 2013-03-07 |
| 20130059762 | METHODS AND COMPOSITIONS FOR MULTIPLEX PCR - The present invention provides methods, compositions, kits, systems and apparatus that are useful for multiplex PCR of one or more nucleic acids present in a sample. In particular, various target-specific primers are provided that allow for the selective amplification of one or more target sequences. In one aspect, the invention relates to target-specific primers useful for the selective amplification of one or more target sequences associated with cancer or inherited disease. In some aspects, amplified target sequences obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing and used to detect the presence of genetic variants. | 2013-03-07 |
| 20130059763 | System for photolithographic synthesis of polymer arrays - The present invention provides novel processes for the large scale preparation of arrays of polymer sequences wherein each array includes a plurality of different, positionally distinct polymer sequences having known monomer sequences. The methods of the invention combine high throughput process steps with high resolution photolithographic techniques in the manufacture of polymer arrays. | 2013-03-07 |
| 20130059764 | CLEANSING COSMETIC - A cleansing cosmetic including (A) a first oil component having an I/O value of from 0.05 to 0.25, in an amount of 30% by mass or more, (B) a liquid form emulsifier including an aliphatic hydrocarbon chain and not including an unsaturated aliphatic hydrocarbon chain, in an amount of more than 10% by mass, and (C) a carotenoid | 2013-03-07 |
| 20130059765 | BLEACHING AGENT PARTICLES COMPRISING SODIUM PERCARBONATE AND A BLEACH ACTIVATOR - Bleach particles with a core of sodium percarbonate, an inner coating layer with at least 50% by weight of sodium sulfate in the form of thenardite or burkeite and an outer coating layer comprising a water-soluble binder and a perhydrolyzable N-acyl compound or O-acyl compound as bleach activator are storage-stable, are suitable for silo storage and can be transported and handled safely even in a hot and humid climate. | 2013-03-07 |
| 20130059766 | CLEANING COMPOSITIONS AND SOIL CAPTURE AGENT FOR CLEANING OBJECTS - A cleaning composition including a soil capture agent for cleaning objects. | 2013-03-07 |
| 20130059767 | FATTY ACID CHAIN SATURATION IN ALKANOL AMINE BASED ESTERQUAT - A composition comprising an esterquat that is a quaternized reaction product of an alkanol amine and a fatty acid having a ratio of fatty acid to alkanol amine of 1.5 to 1.75, wherein 45 to 75% by weight of the fatty acids are saturated. Also, a method of softening a fabric and increasing fragrance delivery comprising treating the fabric with the composition. | 2013-03-07 |
| 20130059768 | LIPID COMPOSITIONS WITH HIGH DHA CONTENT - The invention provides lipid compositions comprising phospholipids having a high docosahexaenoic acid (DHA) content, which compositions are preferably extracted from natural sources. The lipid compositions are excellent sources of highly bioavailable DHA and they can be used in oral delivery vehicles, dietary supplements, functional foods, and the like. | 2013-03-07 |
| 20130059769 | TOPICALLY ADMINISTERED, SKIN-PENETRATING GLYCOSAMINOGLYCAN FORMULATIONS SUITABLE FOR USE IN COSMETIC AND PHARMACEUTICAL APPLICATIONS - The present invention relates to topical glycosaminoglycan compositions, particularly hyaluronan compositions, that facilitate the penetration of modified glycosaminoglycans through the skin barrier into the epidermal and dermal layers of the skin, thereby allowing for the dermal administration of a glycosaminoglycan, such as hyaluronan, without requiring an injection. Through their ability to deliver hyaluronan to the epidermal and dermal layers, the present formulations are therefore suitable for use in dermal rejuvenation, enhancement, hyaluronan replenishment and protection therapy. The glycosaminoglycan compositions are also useful as delivery devices to facilitate the dermal and transdermal delivery of cosmetically and pharmaceutically active substances, including pharmaceuticals, polypeptides, proteins and similarly sized biomacromolecules, through the skin barrier. | 2013-03-07 |
| 20130059770 | POLYPEPTIDES - The invention relates to polypeptides comprising an amino acid sequence which is an analogue of pramlintide, pharmaceutical compositions comprising these polypeptides, and these polypeptides for use as medicaments. | 2013-03-07 |
| 20130059771 | Function and Regulation of Angiopoietin-3/Angiopoietin-4 - The present invention relates to Angiopoietin-3 (Ang-3) and Angiopoietin-4 (Ang-4). The present invention also relates to methods of modulating an activity of Ang-3 or Ang-4. The present invention further relates to methods of treating cancer, diabetes, and arthritis. | 2013-03-07 |
| 20130059772 | Use of Repeat Sequence Protein Polymers in Personal Care Compositions - The present invention provides personal care compositions, and more particularly, personal care compositions comprising a bioactively effective amount of a repeat sequence protein polymer. In some particularly preferred embodiments, the present invention provides personal care compositions comprising an effective amount of at least one fragment of a repeat sequence protein polymer having bioactivity. | 2013-03-07 |
| 20130059773 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATION AND NEUTROPENIA - The present invention concerns compounds modulating apoptosis of neutrophil cells. In particular, the invention concerns compounds inhibiting an interaction between Proliferating Cell Nuclear Antigen (PCNA) and proteins binding to cytoplasmic PCNA in neutrophil cells, for use in the treatment of a disease involving a neutrophil-dependent inflammatory process. The invention also relates to a method for the identification of a compound for use in the treatment of a neutrophil-dependent inflammatory process. The invention further relates to peptides for use in the treatment of neutropenia. | 2013-03-07 |
| 20130059774 | EFFLUX PUMP INHIBITORS - Novel compositions and methods of reducing microbial resistance to antimicrobial agents and treating infections are disclosed. In particular, compositions and methods of inhibiting efflux pump activity, treating infection and methods of enhancing antimicrobial activity of antimicrobial agents are provided. | 2013-03-07 |
| 20130059775 | Nucleic Acid Complexes - The present invention relates to complexes of transcription factor decoys, their delivery to bacteria and their formulation. In particular, the present invention resides in an antibacterial complex comprising a nucleic acid sequence and one or more delivery moieties selected from quaternary amine compounds; bis-aminoalkanes and unsaturated derivatives thereof, wherein the amino component of the aminoalkane is an amino group forming part of a heterocyclic ring; and an antibacterial peptide. | 2013-03-07 |
| 20130059776 | Antiviral Cell-Penetrating Peptides - Disclosed herein are cell penetrating peptides useful as treatment for Human Immunodeficiency Virus. | 2013-03-07 |
| 20130059777 | MODULATION OF GLUCOSE-6-PHOSPHATASE TRANSLOCASE EXPRESSION - Compositions and methods are provided for decreasing blood glucose levels in an animal, comprising administering to said animal an antisense inhibitor of glucose-6-phosphatase translocase expression alone or in combination with at least one glucose-lowering drug. Also provided are compositions and methods for treating diabetes and other metabolic disorders. | 2013-03-07 |
| 20130059778 | Identification of a Genetic Risk Factor for Diabetes - Loss of function ankyrin-B variants have impaired function in pancreatic islets and are associated with type 2 diabetes. This finding provides the basis for methods of identifying at-risk individuals for type 2 diabetes and for personalized therapeutic strategies. | 2013-03-07 |
| 20130059779 | Stabilized Insulin-like Growth Factor Polypeptides - The invention relates to stabilized polypeptides having an IGF-1 sequence and an Ea peptide sequence, where the natural physiological cleavage of the Ea peptide from the IGF-1 is prevented. | 2013-03-07 |
| 20130059780 | BRANCHED PEG REMODELING AND GLYCOSYLATION OF GLUCAGON-LIKE PEPTIDE-1 [GLP-1] - The present invention provides polypeptides that include an O-linked glycoconjugate in which a species such as a water-soluble polymer, a therapeutic agent of a biomolecule is covalently linked through an intact O-linked glycosyl residue to the polypeptide. The polypeptides of the invention include wild-type peptides and mutant peptides that include an O-linked glycosylation site that is not present in the wild-type peptide. Also provided are methods of making the peptides of the invention and methods, pharmaceutical compositions containing the peptides and methods of treating, ameliorating or preventing diseased in mammals by administering an amount of a peptide of the invention sufficient to achieve the desired response. | 2013-03-07 |
| 20130059781 | Long-Acting Gastrin Derivatives - The present invention relates to gastrin derivatives comprising gastrin or an analogue or fragment thereof and a derivatisation group and therapeutic use thereof. | 2013-03-07 |
| 20130059782 | PHOSPHOLIPID-ENRICHED VESICLES BEARING TISSUE FACTOR HAVING HAEMOSTATIC ACTIVITIES AND USES THEREOF - The invention relates to a method for improving the procoagulant properties of TF expressed in eukaryotic cells by contacting microvesicles derived from said eukaryotic cells with a negatively-charged phospholipid such as phosphatidylserine. The invention also relates to microvesicles obtained using said method as well as to the uses thereof as procoagulant agents, for wound healing and for promoting angiogenesis. | 2013-03-07 |
| 20130059783 | COMPOSITIONS AND METHODS FOR EXPANDING BFU-E CELLS - The invention provides methods of expanding BFU-E cells comprising contacting one or more BFU-E cells with a hypoxia inducible factor 1 activator and a glucocorticoid receptor (GR) activator, e.g., a GR agonist. In some embodiments, the FIIF-1 activator is a prolyl hydroxylase inhibitor (PHI). In some embodiments, the method comprises culturing BFU-E in medium containing a HIF-1a activator and a glucocorticoid receptor (GR) activator, e.g., a GR agonist. In some embodiments the BFU-E cells are human cells. The invention provides cell culture media useful for expanding BFU-Es, wherein the cell culture media comprise a HIF-1 activator and a GR activator (e.g., a GR agonist) The invention provides a method comprises administering a HIF-1 activator and a GR agonist to a subject in need thereof. In some embodiments, the subject suffers from anemia. In some embodiments, the anemia is an Epo-resistant anemia. In some embodiments, the anemia is Diamond-Blackfan anemia. | 2013-03-07 |
