| 10th week of 2014 patent applcation highlights part 59 |
| Patent application number | Title | Published |
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| 20140065534 | TONER, DEVELOPER AND IMAGE FORMING APPARATUS - A toner, including: a crystalline resin containing a urethane bond, a urea bond, or both thereof; and a compound represented by the following General Formula (1), wherein an amount of the compound represented by the General Formula (1) is 0.01% by mass to 0.25% by mass: | 2014-03-06 |
| 20140065535 | CORE MATERIAL OF MAGNETIC CARRIER FOR ELECTROPHOTOGRAPHIC DEVELOPER AND PROCESS FOR PRODUCING THE SAME, MAGNETIC CARRIER FOR ELECTROPHOTOGRAPHIC DEVELOPER, AND TWO-COMPONENT SYSTEM DEVELOPER - The present invention provides a magnetic carrier for an electrophotographic developer which has an excellent durability and a stable charging property and is free from occurrence of spent toner thereonto, and a two-component system developer comprising the magnetic carrier for an electrophotographic developer and a toner. The present invention relates to a core material of a magnetic carrier for an electrophotographic developer comprising spherical composite particles comprising at least ferromagnetic iron oxide fine particles and a cured phenol resin and having an average particle diameter of 1 to 100 μm, a resin index of the spherical composite particles being within the range of 35 to 80%, and a magnetic carrier obtained by coating a surface of respective particles of the magnetic carrier core material with a resin. | 2014-03-06 |
| 20140065536 | TONER FOR ELECTROSTATIC-CHARGE IMAGE DEVELOPMENT AND METHOD FOR PRODUCING TONER FOR ELECTROSTATIC-CHARGE IMAGE DEVELOPMENT - A toner for electrostatic-charge image development contains toner particles in which the surfaces of core particles, including a binder resin composed of a polyester resin, are coated with shell layers. The shell layer is formed of a resin composed of a copolymer of monomers including a monomer having a quaternary ammonium group and a (meth)acrylic copolymer. The molar ratio of units derived from a monomer having a quaternary ammonium group is 5 mol % or more and 35 mol % or less. | 2014-03-06 |
| 20140065537 | CONTINUOUS PROCESS FOR MANUFACTURING TONERS - The continuous process for manufacturing toners disclosed herein includes continuously feeding components of a toner composition into a feed section of a screw extruder at a controlled rate. The continuous process for manufacturing toners may include feeding the components of a toner composition into the feed section of a screw extruder without performing an external or secondary dispersion step. That is to say, the components of the toner composition may be fed directly into the extruder without using dispersions of individual components as used in batch processes. Rather, the toner components are added to the extruder in dry form, melt-mixed, and may be dispersed in aqueous form in the extruder. The process may produce micron-sized toner particles, thus no further size reduction may be necessary. | 2014-03-06 |
| 20140065538 | POSITIVE-WORKING LITHOGRAPHIC PRINTING PLATE PRECURSOR FOR INFRARED LASER AND PROCESS FOR MAKING LITHOGRAPHIC PRINTING PLATE - A positive-working lithographic printing plate precursor for infrared laser is provided that includes, layered sequentially above a support, a lower layer and an upper layer, the lower layer and/or the upper layer including an infrared absorbing agent, either the lower layer comprising an alkali-soluble group-containing graft copolymer or the upper layer comprising a sulfonamide group-, active imide group-, and/or amide group-containing graft copolymer, and the graft copolymer being a polyurethane resin having as a graft chain an ethylenically unsaturated monomer-derived constitutional unit. There is also provided a process for making a lithographic printing plate, the process including in sequence an exposure step of imagewise exposing by means of an infrared laser the positive-working lithographic printing plate precursor for infrared laser and a development step of developing using an aqueous alkali solution with a pH of 8.5 to 10.8. | 2014-03-06 |
| 20140065539 | POSITIVE-WORKING LITHOGRAPHIC PRINTING PLATE PRECURSORS AND USE - A thermally-sensitive, positive-working lithographic printing plate precursor can be used to prepare lithographic printing plates using high pH, silicate-free processing solutions. The precursor has a grained an anodized aluminum-containing substrate including a poly(vinyl phosphonic acid) interlayer. A first ink receptive layer, and optionally a second ink receptive layer, is disposed directly on the poly(vinyl phosphonic acid) interlayer. This first ink receptive layer comprises an aromatic acid dye that comprises at least two aromatic groups in an amount of least 0.5 weight %. In addition, the precursor comprises an infrared radiation absorber in one of the layers. | 2014-03-06 |
| 20140065540 | PHOTORESIST AND COATED SUBSTRATE COMPRISING SAME - A polymer includes the polymerized product of monomers including a nitrogen-containing monomer comprising formula (Ia), formula (Ib), or a combination of formulas (Ia) and (Ib), and an acid-deprotectable monomer having the formula (II): | 2014-03-06 |
| 20140065541 | Method of Stabilizing Fluorine-Containing Acid Amplifier - A method of stabilizing a fluorine-containing acid amplifier. The method is provided to include the step of dissolving a fluorine-containing acid amplifier in an organic solvent thereby producing a solution of the fluorine-containing acid amplifier, the fluorine-containing acid amplifier being represented by general formula (1): | 2014-03-06 |
| 20140065542 | PHOTORESIST COMPOSITION AND METHOD OF FORMING A BLACK MATRIX USING THE SAME - A photoresist composition includes a binder resin combined with a black dye, a monomer, a photo-polymerization initiator and a remainder of a solvent. | 2014-03-06 |
| 20140065543 | NEW COMPOUND, PHOTOSENSITIVE COMPOSITION COMPRISING THE SAME AND PHOTOSENSITIVE MATERIAL - The present application relates to a novel compound, a photosensitive composition comprising the same and a photosensitive material. | 2014-03-06 |
| 20140065544 | RESIST COMPOSITION AND PATTERNING PROCESS - A polymer capable of increasing alkali solubility under the action of acid, as a base resin is blended with a copolymer comprising recurring units derived from acenaphthylene, indene, benzofuran or benzothiophene and fluorine-containing recurring units, as a polymeric additive to formulate a resist composition. The photoresist film formed using the resist composition is effective for minimizing outgassing therefrom during the EUV lithography. The resist film has a hydrophilic surface and is effective for suppressing formation of blob defects after development. | 2014-03-06 |
| 20140065545 | RESIST COMPOSITION AND PATTERNING PROCESS - A polymer capable of increasing alkali solubility under the action of acid, as a base resin is blended with a copolymer comprising recurring units derived from (meth)acrylate, vinyl ether, vinylfluorene, vinylanthracene, vinylpyrene, vinylbiphenyl, stilbene, styrylnaphthalene or dinaphthylethylene, and fluorine-containing recurring units, as a polymeric additive to formulate a resist composition. The photoresist film formed using the resist composition is effective for minimizing outgassing therefrom during the EUV lithography. The resist film has a hydrophilic surface and is effective for suppressing formation of blob defects after development. | 2014-03-06 |
| 20140065546 | RESIST COMPOSITION AND PATTERNING PROCESS - A polymer capable of increasing alkali solubility under the action of acid, as a base resin is blended with a polymer comprising recurring units derived from a styrene having 1,1,1,3,3,3-hexafluoro-2-propanol as a polymeric additive to formulate a resist composition. The photoresist film formed using the resist composition is effective for minimizing outgassing therefrom during the EUV lithography, reducing LWR after development, and suppressing formation of blob defects after development because of its hydrophilic surface. | 2014-03-06 |
| 20140065547 | CHARGED PARTICLE BEAM APPARATUS, DRAWING APPARATUS, AND METHOD OF MANUFACTURING ARTICLE - An apparatus includes: an image sensor including pixels which constitute rows; and a controller configured to control an irradiation operation of irradiating a pixel of the image sensor with a charged particle beam to generate a signal charge, a transfer operation of sequentially transferring, pixel by pixel in a column direction, the signal charge accumulated in the irradiated pixel, and an output operation of outputting the transferred signal charge from the image sensor. The controller is configured to cause a first irradiation operation for a first part of the rows as an irradiated region, a transfer operation of transferring a signal charge generated in the first part to a second part of the rows adjacent to the first part, as a non-irradiated region, and a second irradiation operation for the first part, to be performed sequentially. | 2014-03-06 |
| 20140065548 | LITHOGRAPHY APPARATUS AND ARTICLE MANUFACTURING METHOD USING SAME - A lithography apparatus converts vector pattern data into bitmap data and performs writing on a substrate with a charged particle beam based on the bitmap data. Here, the lithography apparatus includes a display unit and a processing unit that causes the display unit to display an image corresponding to the bitmap data and performs processing for updating the bitmap data by changing at least one of a pixel value, dimension, and shape of the image displayed on the display unit via a graphical user interface. | 2014-03-06 |
| 20140065549 | DRAWING APPARATUS AND METHOD OF MANUFACTURING ARTICLE - The present invention provides a drawing apparatus for performing drawing on a substrate using a plurality of charged particle beams, the apparatus including an aperture array including an opening region including a region in which a plurality of openings are formed to generate the plurality of charged particle beams, and a peripheral region surrounding the opening region, wherein the aperture array has a shielding structure for shielding at least part of an electric field generated by charging of a contaminant in the peripheral region with respect to the plurality of charged particle beams passing through the plurality of openings. | 2014-03-06 |
| 20140065550 | POLYMER COMPRISING END GROUPS CONTAINING PHOTOACID GENERATOR, PHOTORESIST COMPRISING THE POLYMER, AND METHOD OF MAKING A DEVICE - A polymer comprises the polymerized product of unsaturated monomers comprising an acid-deprotectable monomer, a base-soluble monomer, a lactone-containing monomer, a photoacid-generating monomer, or a combination comprising at least one of the foregoing monomers, with a chain transfer agent of Formula (I); | 2014-03-06 |
| 20140065551 | Lithographic Pattern Development Process For Amorphous Fluoropolymer - Here we disclose a lithographic pattern development process for amorphous fluoropolymers. Amorphous fluoropolymers are a class of plastic materials with high chemical inertness and favorable optical properties. Exposure of surface-deposited layers of such polymer with high energy radiation leads to a change in the chemical structure of the polymer, which selectively compromises the solubility of the exposed areas in fluorinated organic solvents. Micro- and nanopatterning with a feature size down to <50 nm was achieved by dissolving and removing unexposed amorphous fluoropolymer from exposed, surface deposited films. The amorphous fluoropolymer functions thus as a negative resist. | 2014-03-06 |
| 20140065552 | Methods For Small Trench Patterning Using Chemical Amplified Photoresist Compositions - A method for forming a pattern on a substrate is described. The method includes providing a substrate, forming a photosensitive layer over the substrate, exposing the photosensitive layer to a first exposure energy through a first mask, exposing the photosensitive layer to a second exposure energy through a second mask, baking the photosensitive layer, and developing the exposed photosensitive layer. The photosensitive layer includes a polymer that turns soluble to a developer solution, at least one photo-acid generator (PAG), and at least one photo-base generator (PBG). A portion of the layer exposed to the second exposure energy overlaps with a portion exposed to the first exposure energy. | 2014-03-06 |
| 20140065553 | CHUCK AND SEMICONDUCTOR PROCESS USING THE SAME - An apparatus of semiconductor process including a chuck and a vacuum source is provided. The chuck has a plurality of holes for holding a semiconductor substrate, and the vacuum source is used for providing vacuum suction through the holes to make the semiconductor substrate be subjected to varied suction intensities according to a warpage level thereof. | 2014-03-06 |
| 20140065554 | Method and Apparatus for Developing Process - The present disclosure involves a method of fabricating a semiconductor device. The method includes providing a substrate having a material layer formed thereon; depositing a photoresist layer on the material layer, the photoresist layer having a vertical dimension; exposing a region of the photoresist layer to radiation, the exposed region having a horizontal dimension, wherein a first ratio of the vertical dimension to the horizontal dimension exceeds a predetermined ratio; and developing the photoresist layer to remove the exposed region at least in part through applying a developer solution containing a first chemical and a second chemical, wherein: the first chemical is configured to dissolve the exposed region of the photoresist layer through a chemical reaction; the second chemical is configured to enhance flow of the first chemical that comes into contact with the photoresist layer; and an optimized second ratio exists between the first chemical and the second chemical. | 2014-03-06 |
| 20140065555 | MANUFACTURING METHOD OF SEMICONDUCTOR DEVICE - According to one embodiment, a manufacturing method includes forming a desired pattern containing an uneven pattern on a substrate, subjecting the surface of the desired pattern to a water repellent treatment, forming a resist film on the desired pattern, performing an exposure treatment to expose the uneven pattern, rinsing the substrate with water, and drying the substrate. | 2014-03-06 |
| 20140065556 | PATTERNING METHOD - According to one embodiment, a patterning method includes exposure-transferring a plurality of first island pattern images and a plurality of second island pattern images onto a resist film, each of the plurality of first island pattern images having a configuration having a contour line or a major axis extending in a third direction, the plurality of first island pattern images having a staggered arrangement, each of the plurality of second island pattern images having a configuration having a contour line or a major axis extending in a fourth direction, the plurality of second island pattern images having a staggered arrangement, the first island pattern images and the second island pattern images being continuous in the first direction by a portion of each of the second island pattern images overlapping one of the first island pattern images. | 2014-03-06 |
| 20140065557 | METHOD FOR USING A PURGE RING WITH SPLIT BAFFLES IN PHOTONIC THERMAL PROCESSING SYSTEMS - A method for supplying a first gas and a second gas using a purge ring in a photonic processing system includes arranging a first layer and a second layer to define a first plenum and a first baffle, arranging the second layer and a third layer to define a second plenum and a second baffle, receiving a first gas at the first plenum that flows through the first plenum and the first baffle to an inner region, and receiving a second gas at the second plenum that flows through the second plenum and the second baffle to the inner region. The second baffle is one of less restrictive and more restrictive than the first baffle. | 2014-03-06 |
| 20140065558 | ELECTRICALLY STABILIZED BURNER - An electrically stabilized burner is configured to support a combustion reaction such as a combustion reaction substantially at a selected fuel dilution and with a mixing rate selected to maximize the reaction rate without quenching the combustion reaction. | 2014-03-06 |
| 20140065559 | PRESSURIZED OXY-COMBUSTION POWER BOILER AND POWER PLANT AND METHOD OF OPERATING THE SAME - A pressurized oxy-combustion circulating fluidized bed power plant having a circulating fluidized bed boiler is provided. A combustion chamber of the boiler is in fluid communication with a separator and configured so that solids produced during combustion enter the separator. The power plant further includes an air separation unit that is in fluid communication with the combustion chamber. The air separation unit is configured to supply substantially pure oxygen to the combustion chamber at a pressure greater than 1 bar. An external heat exchanger is in fluid communication with the separator and in fluid communication with the combustion chamber. The external heat exchanger is configured so that a portion of the solids received in the separator pass through the external heat exchanger and transfer heat to a working fluid, after which the solids are returned to the combustion chamber to moderate or control the temperature in the combustion chamber. | 2014-03-06 |
| 20140065560 | METHOD OF OPERATING AN OXY-FUEL BOILER SYSTEM - The present disclosure relates to a method of operating a boiler system that includes an oxyfuel boiler in which an oxygen stream and a fuel stream are combusted to generate a stream of flue gas, an oxygen gas source producing the stream of oxygen for the boiler, and a gas processing unit for cleaning and compressing at least a portion of the stream of flue gas generated in the boiler for producing a stream of pressurized fluid comprising carbon dioxide. The method includes operating the boiler system, at least for a period of time, in an evaporation mode, in which a stream of oxygen from the oxygen gas source in liquid form is evaporated prior to being introduced in the boiler by transferring heat energy to the stream of liquid oxygen from a first stream of carbon dioxide of the gas processing unit. The present disclosure further relates to a boiler system for an oxy-fuel process as well as to a power plant comprising such a system. | 2014-03-06 |
| 20140065561 | SINGLE-FIREBALL TANGENTIALLY-FIRING BOILER FOR THE BURNING OF ANTHRACITE - A tangentially-fired furnace for the burning of anthracite is disclosed. The furnace may contain a boiler with a chamber having four corners. Four burner groups located at the four corners may be configured to eject pulverized coal flow into the chamber for combustion, in order to form a single fireball substantially at the center of the chamber during combustion. Each burner group may contain a first burner which includes primary-air/rich-portion nozzles for ejecting rich-portion coal flow into a lower section of the chamber, and a second burner which includes primary-air/thin-portion nozzles for ejecting thin-portion coal flow into a higher section of the chamber. | 2014-03-06 |
| 20140065562 | PREMIX BURNER - This invention relates to a premix burner for operating a heat generator, the burner at least having a swirl generator, a mixing section downstream of the swirl generator and a transition piece for transferring the swirl flow from the swirl generator into the mixing section. The invention further refers to a transition piece for such a premix burner. The transition piece includes an inlet, connected to the swirl generator, an outlet, connected to the mixing tube, and a continuing flow limiting interior contour between said inlet and said outlet, wherein at least in an inlet section said interior contour is curved radially inwards towards the inner diameter of the mixing tube and wherein at the outlet the interior contour is flush with an interior flow limiting contour of the mixing tube. | 2014-03-06 |
| 20140065563 | MATERIAL HEATING METHOD - A material heating method includes: a step of charging a silicon-containing carbon steel material into a heating furnace; a step of preheating the material; a first heating step of raising the temperature of the material; a second heating step of lowering the temperature of the material so as to reduce a temperature difference between the surface and inside of the material; a third heating step of raising the temperature of the material; and a soaking step of reducing the temperature difference between the surface and inside of the material. The temperature of the material in the heating furnace is maintained at the melting point of fayalite or lower. | 2014-03-06 |
| 20140065564 | PREHEAT BURNER ASSEMBLY AND METHOD - A preheat burner assembly and method for preheating forming dies includes a frame, a burner manifold and a link assembly. The burner manifold as a plurality of burner orifices for preheating the forming dies. The burner manifold is connected to a fuel source. The link assembly mounts the burner manifold to the frame for movement between a stowed position and a deployed position. The burner is moved via the link assembly to a deployed position for preheating the forming dies. The forming dies are preheated. The burner manifold is subsequently moved via the link assembly from the deployed position to an upright stowed position. | 2014-03-06 |
| 20140065565 | METHOD OF PRODUCING COMPOSITE METAL OXIDE, METAL OXIDE SINTERED BODY, AND ROTARY KILN - Provided is a method of producing a composite metal oxide including, to calcine a composition containing an alkali metal and obtain a composite metal oxide, calcining the composition while being arranged on a mount a part of which in contact with the composition is formed of a metal oxide component. The metal oxide component has a content of K atoms ranging from 5 to 13 parts by weight in terms of K | 2014-03-06 |
| 20140065566 | LOW PROFILE SELF-LIGATING ORTHODONTIC APPLIANCE WITH CLIP - An orthodontic appliance includes a body ( | 2014-03-06 |
| 20140065567 | Dynamic Bracket System - This invention is an adjustable orthodontic bracket system which allows brackets to be adjusted for the particular angulations required for each individual tooth of any patient, while continuously attached to the tooth surface. The orthodontist manually adjusts the relationship of the bracket component with the frame and bracket base during treatment eliminating the necessity of repositioning bracket components due to erroneous positioning. The bracket component is positioned such that it can move completely in all directions to achieve the proper angulation for tooth repositioning. The base of the bracket component and the interior surface of the bracket compartment are textured to provide friction and secure the components once positioned for proper tooth movement. The exterior of the bracket component is also textured to provide more secure attachment to the surface of the tooth. This system will lead to lower treatment cost and quicker adjustments of the orthodontic bracket system. | 2014-03-06 |
| 20140065568 | Dynamic Bracket System - This invention is a dynamic orthodontic bracket system which allows brackets to be adjusted for particular angulations required for each individual tooth of a patient, while the frames are continuously attached to tooth surface. The orthodontist manually adjusts the relationship of a bracket and a frame during treatment eliminating the necessity of a full repositioning of all components. The bracket is positioned such that it can move in various directions to achieve a proper angulation for tooth repositioning. The base of the bracket and the interior surface of the frame can be textured to provide friction and secure the components once positioned for proper tooth movement. The exterior of the frame can also be textured to provide more secure attachment to the surface of the tooth. This system will lead to lower treatment cost and quicker adjustments of the orthodontic bracket system. | 2014-03-06 |
| 20140065569 | METHOD AND DEVICE FOR CAUSING TOOTH MOVEMENT - A method of increasing movement of a tooth in a jaw having at least one tooth with an orthodontic brace thereon includes: (1) holding a handle of a device, the device having an elongate member extending from the handle and a screw tip at a distal end of the elongate member; (2) moving a sleeve along the elongate member to set a length of exposed screw tip; (3) locking the sleeve in place relative to the screw tip; (4) drilling a hole with the screw tip through a cortical bone of a jaw to increase movement of the tooth; and (5) stopping the drilling when the length of exposed screw tip has penetrated the jaw. | 2014-03-06 |
| 20140065570 | LIGHT GUIDE TYPE PAIN RELIEVER - A light guide type pain reliever includes a handle including a barrel accommodating a battery, a rear end cap and a front end cap respectively capped on two opposite ends of the barrel, a pushbutton mounted in the rear end cap and a switching connector mounted in the rear end cap and electrically connected to the battery and drivable by the pushbutton to switching on/off the battery, a holder shell connected to the front end cap and electrically coupled to the battery and having electrically connected thereto a vibrator and a light-emitting device, an adapter connected to the holder shell, and a light guide plate connected to adapter guiding out light rays emitted by the light-emitting device. | 2014-03-06 |
| 20140065571 | INTRAORAL MAXRETRACTOR - An intraoral retractor includes a main body plane with one curved end and is dented in the middle to avoid injure the frenum; and the other end is a handle bended 30 degree away from the plan of the body. The grasper is inserted within a patient's mouth to retract the lip and open the patient's mouth vertically, while the handle allows easy operation. With the retractor, the operator can pull the patient's upper or lower lip as desired and examine the upper or lower dentition, which is highly useful for intraoral photography, dental checkups and treatments. | 2014-03-06 |
| 20140065572 | Anti-Rotation Instrument - The present invention features an anti-rotation instrument system which could be applied/used in all health professions such as medical, dental, and any other specialties. The system includes an anti-rotation instrument device comprising a main handle, a first removable hand grip and a first instrumental tip. The first removable hand grip is attached to a first female screw cavity disposed on the main handle. One end of the instrumental tip passes through a channel disposed within first hand grip with an anti-rotation key disposed on the instrumental tip securely reside within a dent disposed on the distal end of the first removable hand grip and the threading disposed on the end of the instrumental tip is subsequently screwed into the first female screw cavity of the main handle such that the first hand grip is tightly sandwiched between the first instrumental tip and main body. | 2014-03-06 |
| 20140065573 | DRILL FOR IMPLANT SURGERY - Disclosed is a drill for implant surgery drill for implant surgery. The drill includes a drill connecting part having a drill top portion formed at one side of the top portion thereof, a drill fixing groove formed on the lower portion of the drill top portion, and a drill connecting body formed on the lower portion of the drill fixing groove; and a drilling part disposed on the underside of the drill connecting part and having a cylindrical shape in such a manner as to be small in diameter toward the lower portion thereof and to have a space portion formed at the inside thereof. | 2014-03-06 |
| 20140065574 | SCREW CHANNEL DIRECTING DEVICE FOR A DENTAL SUPERSTRUCTURE AND METHODS FOR MANUFACTURING A DENTAL SUPERSTRUCTURE - A screw channel directing device ( | 2014-03-06 |
| 20140065575 | METHOD AND APPARATUS FOR TREATMENT OF SOLID MATERIAL INCLUDING HARD TISSUE - An apparatus for treatment of dental tissue has a first laser source optically connected to a first channel and the same first laser source optically connected to a second channel. The second laser source is optically connected to the first channel. That second laser source is designed to be pumped via the first channel by the diode laser to generate a power of radiation sufficient to cut hard dental tissue. The second channel is connected to a device for treatment of soft dental tissue and is designed to transmit radiation sufficient for treating soft dental tissue. The first laser source can be a diode laser designed to emit radiation of a wavelength selected from a range of 700 nm to 2700 nm. The second laser source can be a solid-state or fiber laser designed to emit a wavelength from a range of 2700 nm to 3000 nm. | 2014-03-06 |
| 20140065576 | Device for Visualizing Military Operations - A device for visualizing military operations for depicting a scenario for a plurality of action subjects represents each action subject by a representative. The device for visualizing military operations has a memory unit, a first representation unit, and a computing unit. The computing unit is designed to control the first representation unit in such a way that a scenario stored in the memory unit together with the action subjects represented by the representatives are reproduced. | 2014-03-06 |
| 20140065577 | Air-Gun Simulated Training Weapon - A non-lethal, air-gun training weapon that is used to realistically simulate the behavior of a live firearm. The non-lethal, air-gun training weapon provides an air-gun to simulate the weight and feel of a live firearm. A magazine that attaches to the air-gun houses a gas container, which feeds compressed gas into the air-gun. The release of compressed gas actuates a laser assembly and a bolt both housed within the air-gun. The laser assembly allows users to track dry-fired shots, while movement of the bolt simulates the recoil of a live firearm. An electromechanical system housed within the magazine features a transceiver that is capable of wirelessly transmitting and receiving information from an external computer system. The electromechanical assembly also includes a jamming mechanism that can be activated by a controller board in order to simulate an empty clip or jammed weapon. The jamming mechanism can be manually or remotely reset. | 2014-03-06 |
| 20140065578 | AIRBURST SIMULATION SYSTEM AND METHOD OF SIMULATION FOR AIRBURST - The present disclosure relates to an airburst simulation system and method. The airburst simulation system includes a laser emitting unit to emit laser beam to an airburst aiming position, preset above a target hidden behind an obstacle, such that a warhead is airbursted to shoot the target, a laser detecting unit mounted onto the target to detect an arrival of the laser beam above the target, and a determining unit to measure a distance between the airburst aiming position and an arrival position of the laser detected by the laser detecting unit, and determine whether or not the target has been shot based on the distance. This allows for a simulated engagement using an airburst apparatus, with no harm to human bodies by virtue of the use of laser. | 2014-03-06 |
| 20140065579 | BRAILLE ERASURE MECHANISM - An improved Braille erasure mechanism may comprise a reverse-embosser or impressing mechanism to imprint a negative Braille cell. A negative Braille cell is the reverse of a normal Braille cell, with one or more dots lowered or pressed into the printing medium in an opposite direction to the raised dots of a normal Braille cell. Because the dots of a negative Braille cell are lowered past the surface of the printing medium, they may be ordinarily undetectable to the fingers of a Braille user. Accordingly, by imprinting a full negative Braille cell on top of a Braille cell to be erased, all of the previously raised dots of the Braille cell may be lowered beyond the surface of the printing medium. Any further Braille cell embossed over the erased cell will be free from corruption, because any dot not used by the new cell will remain lowered and undetectable. | 2014-03-06 |
| 20140065580 | Method and System of Emulating a Patient Programmer - The present disclosure involves a method of emulating a patient programmer. A first language is associated with a virtual representation of the patient programmer. The first language corresponds to a language understood by a healthcare professional. A second language is associated with the virtual representation of the patient programmer. The second language corresponds to a language understood by a patient user of the patient programmer. The virtual representation of the patient programmer is displayed in the first language and in the second language simultaneously. | 2014-03-06 |
| 20140065581 | System and Method for Evaluating Reading Fluency Using Underlining - A system of evaluating reading fluency by monitoring the underlining of text as it is being read on a tablet or other computing device. The text or passage is presented on the screen of the tablet computing device with a touchscreen, such as, but not limited to, an iPad. The reader uses a stylus, finger, or other device to underline each word as it is read, and may go back and re-underline any words to regress within the passage. Alternatively, a mouse can be used to indicate words as they are read. Computer software tracks the reader's underlining, providing detailed information about reading rate, pauses, regressions, and other word and word combination features. | 2014-03-06 |
| 20140065582 | Method and System for Learning Call Analysis - A system and method are presented for learning call analysis. Audio fingerprinting may be employed to identify audio recordings that answer communications. In one embodiment, the system may generate a fingerprint of a candidate audio stream and compare it against known fingerprints within a database. The system may also search for a speech-like signal to determine if the end point contains a known audio recording. If a known audio recording is not encountered, a fingerprint may be computed for the contact and the communication routed to a human for handling. An indication may be made as to if the call is indeed an audio recording. The associated information may be saved and used for future identification purposes. | 2014-03-06 |
| 20140065583 | INTRA-OPERATIVE FIRE/SMOKE SIMULATION DEVICE - A simple, low-cost but extremely effective means to represent an intraoperative (for example) fire that highlights recognition using multi-sensual stimulation. The device can be used as part of a high fidelity simulation program that includes an explosion (sound), profuse smoke (visual), and odor (smells) to simulate an intraoperative fire. The design is re-usable, simple to set up, and does not use toxic agents (either to participants or mannequin). | 2014-03-06 |
| 20140065584 | VIRTUAL TESTING AND INSPECTION OF A VIRTUAL WELDMENT - Arc welding simulations that provide simulation of virtual destructive and non-destructive testing and inspection of virtual weldments for training purposes. The virtual testing simulations may be performed on virtual weldments created using a virtual reality welding simulator system (e.g., a virtual reality arc welding (VRAW) system). The virtual inspection simulations may be performed on “pre-canned” (i.e. pre-defined) virtual weldments or using virtual weldments created using a virtual reality welding simulator system. In general, virtual testing may be performed using a virtual reality welding simulator system (e.g., a virtual reality arc welding (VRAW) system), and virtual inspection may be performed using a standalone virtual weldment inspection (VWI) system or using a virtual reality welding simulator system (e.g., a virtual reality arc welding (VRAW) system). However, in accordance with certain enhanced embodiments of the present invention, virtual testing may also be performed on a standalone VWI system. | 2014-03-06 |
| 20140065585 | SYSTEM AND METHOD FOR ASSESSING AND IMPROVING A USERS LIFE SKILLS AND SELF-EFFICACY FOR LIFE STAGE READINESS - A computer-implemented mental and emotional life efficacy development system and method are disclosed which assist lay individuals to measure and improve their mental health and emotional capabilities and life skill deficits to increase the individual's ability to achieve life efficacy. A scoring subsystem measures competencies or deficits in a breadth of critical life skills. The system provides feedback concerning personality traits and mental and emotional deficits and compares the user's scores to the scores of those who are successfully navigating a particular life step. This pinpoints deficits for which the user can receive training and treatment tailored to that user's personality and individual difficulties. Through the collection and aggregating of such symptoms, a preliminary diagnosis is made of the user's mental health and life skills. This diagnosis is subsequently refined before it is used to offer emotion and/or mental health care treatment and life skills training for life efficacy competency. | 2014-03-06 |
| 20140065586 | Method of recording a motion for robotic playback - A method of recording the motion of a physical object moved under human control is described that allows repeated replay of the exact motion using a robot to cause the motion of the object to occur in such a way as to allow a human student to interact with the object and experience the fundamental movements required to reproduce the motion consistently, thereby enhancing motor learning. | 2014-03-06 |
| 20140065587 | Personal Communication Device For Managing Individual Fitness Training - Managing individual fitness training over a communications network comprising a mobile client device ( | 2014-03-06 |
| 20140065588 | Toothbrush Training System - A toothbrush training system for children includes an instrumented toothbrush with physics sensors, along with optional feedback elements, interacting with a dynamic audio-visual instructional program providing guidance, assessment and feedback on proper brushing procedures. The system provides instruction on tooth brushing technique in combination with monitoring and corrective feedback based on that technique in the context of an audio-visual game environment. The instructional program uses an animated character to illustrate the desired toothbrush positioning and movement for cleaning specific tooth surfaces. The content and progress of the audio-visual presentation may be dynamically altered based on data received from the toothbrush to adjust the presentation in response to a comparison of the instructional information and the actual tooth brushing movement performed by the user. | 2014-03-06 |
| 20140065589 | HEALTHCARE TRAINING SYSTEM AND METHOD - A healthcare simulation system includes a mannequin with active physiological characteristics, a display monitor adapted for displaying physiological parameters and a computer for controlling the mannequin and the monitor. A healthcare simulation method includes the steps of programming the computer with healthcare scenarios, operating active characteristics of the mannequin and dynamically displaying physiological parameters corresponding to patient vital signs. Alternative aspects of the invention include tools, such as computers and other equipment, for obtaining and displaying information and for interconnecting and interfacing participants, subjects and controllers in training systems and methods. | 2014-03-06 |
| 20140065590 | METHOD, SYSTEM, AND COMPUTER-READABLE RECORDING MEDIUM FOR PROVIDING EDUCATION SERVICE BASED ON KNOWLEDGE UNITS - According to one aspect of the present invention, a method for providing education service based on knowledge units is provided, comprising the steps of: (a) generating a curriculum based on a user's achievement for at least one knowledge unit, said curriculum including at least one problem composed based on said at least one knowledge unit; and (b) providing said at least one problem to said user. | 2014-03-06 |
| 20140065591 | COLLABORATIVE LEARNING SYSTEM - In one aspect, in general, a system comprises a computer system configured to enable users to interact with a collection of learning groups, each learning group associated with at least one group leader and having members each approved by a group leader, and within each learning group, instances of training programs chosen by the group leader from a library of training programs available to the system, each instance of a training program includes a collection of lessons, each lesson includes a multimedia portion and an interactivity portion, the interactivity portion enabling asynchronous interaction among the members of the learning group, the multimedia portion being available to users other than members of the learning group, and the interactivity portion being available only to the members of the learning group | 2014-03-06 |
| 20140065592 | INTERACTIVE LEARNING AND PERFORMANCE ENHANCEMENT SYSTEM - The present invention comprises a system and method for monitoring participants in an educational environment and comprises: obtaining a set of predefined parameters, obtaining a first data set and a second data set, wherein the first data set comprises standardized summary data relating to the educational environment and the second data set comprises non-standardized granular data relating to the educational environment, converting the second data set into a standardized data set (a third data set) by identifying relationships between a value in the first data set and a value in the second data set, storing the standardized data sets in a consolidated data set on a memory resource, and generating a notification when the data in the consolidated data set satisfies the set of predefined parameters. | 2014-03-06 |
| 20140065593 | Automated Assessment and Analysis System - The present invention relates to the field of automated evaluation, assessment and analysis. Disclosed is a method to create and store assignments, automatically analyze student accuracy and ability, and store analysis on individual students for an extended amount of time. This method can reduce the time and effort exerted by teachers in the creation and grading of assignments and more effectively analyzes student progress than any known software. An assessment software, “TEACH-TECH,” combined with a web-based database, “Cloud,” in the novel manner disclosed provides a means for substantially increasing the effectiveness of the educational system. | 2014-03-06 |
| 20140065594 | CREATING ASSESSMENT MODEL FOR EDUCATIONAL ASSESSMENT SYSTEM - A method, a system, and a computer program product for creating an assessment model are disclosed. Marked regions in an electronic document are identified. Thereafter, mark-ups within the marked regions are identified. Based on the identified marked regions and mark-ups the assessment model is created. | 2014-03-06 |
| 20140065595 | STANDARDIZED TEST AND SURVEY IMAGING SYSTEM - Disclosed herein, among other things, is an imaging system for processing educational assessments. According to one embodiment of the present subject matter, educational assessments are received in a paper format and processed from the paper format to an electronic format. A navigation console is provided and adapted to provide a portal and a login interface to a user. Educational assessment documents are scanned and images are generated. The images are passed through applications to derive data from the images, and the data is transferred to peripheral systems, according to various embodiments. | 2014-03-06 |
| 20140065596 | REAL TIME LEARNING AND SELF IMPROVEMENT EDUCATIONAL SYSTEM AND METHOD - A computer-implemented method of generating learning exercises is provided. The method comprises receiving text, processing the text using linguistic parsers to generate linguistic characteristics of the text, storing the linguistic characteristics in a data file, retrieving user information comprising a user knowledge level and user goals, using the stored linguistic characteristics and the user information to generate the learning exercises based on a parametrical model, receiving responses to the learning exercises from the user, and updating the user information based on the responses to the learning exercises. The linguistic characteristics comprise words of the text and relationships between the words. | 2014-03-06 |
| 20140065597 | APPARATUSES FOR AND METHODS OF PROCESSING CELLS AND RELATED STRUCTURES - Apparatus for processing life-based organic particles, including particles selected from the list comprising cells, cellular spheroids, tissues, eukaryotes, micro-organisms, organs or embryos, comprises a hollow volume ( | 2014-03-06 |
| 20140065598 | SELF-CONTAINED BIOLOGICAL ASSAY APPARATUS, METHODS, AND APPLICATIONS - A self-contained, fully automated, biological assay-performing apparatus includes a housing; a dispensing platform including a controllably-movable reagent dispensing system, disposed in the housing; a reagent supply component disposed in the housing; a pneumatic manifold removably disposed in the housing in a space shared by the dispensing platform, removably coupled to a fluidic transport layer and a plurality of reservoirs, wherein the fluidic transport layer, the reservoirs, and a test sample to be introduced therein are disposed in the housing in the space separate from the dispensing platform; a pneumatic supply system removably coupled to the pneumatic manifold in the housing in a space separate from the dispensing platform; and a control system coupled to at least one of the dispensing platform and the pneumatic supply system, disposed in the housing. | 2014-03-06 |
| 20140065599 | NOVEL POLYMAVIRUS ASSOCIATED WITH DIARRHEA IN CHILDREN - Provided is a new polyomavirus, provisionally named MX polyomavirus, (MXPyV). Further provided are cDNA nucleic acid sequences, recombinant proteins, expression vectors and host cells, recombinant anti-MXPyV antibodies, vaccines, compositions, methods of detecting MXPyV, methods for assaying for anti-MXPyV compounds, and methods for treating or preventing a MXPyV infection. | 2014-03-06 |
| 20140065600 | METHOD OF EVALUATING ORAL CANCER RISK IN HUMAN - A method of providing a risk evaluation and diagnosis of human oral cancer, by examining at the presence in human saliva sample of a combination of particulate nucleic acids from bacteria, virus, as well as human, and/or the presence of particulate biochemical volatile organic compounds, which are indicative of an increased risk of oral cancer. | 2014-03-06 |
| 20140065601 | METHOD AND KIT FOR ESTIMATING HUMAN IMMUNODEFICIENCY VIRUS (HIV) INCIDENCE - The present invention provides a method for determining the incidence of human immunodeficiency virus (HIV) infections in a population comprising comparing the anti-HIV antibody levels of in vitro stimulated tissue samples to those of un-stimulated tissue samples from individual members of said population and related kits. The present invention also provides a method of determining the distribution of recent, non-recent, and late stage human immunodeficiency virus (HIV) infections in a population comprising comparing the in vitro stimulated anti-HIV immunoreactivity and un-stimulated anti-HIV immunoreactivity in tissue samples from individual members of said population and related kits. | 2014-03-06 |
| 20140065602 | Human Exhaled Aerosol Droplet Biomarker System and Method - A system and method for detecting a biomarker in exhaled breath condensate nanodroplets comprises noninvasively collecting exhaled breath condensate nanodroplets of a subject, and analyzing said nanodroplets utilizing immuno-quantitative polymerase chain reaction to detect one or more target biomarkers. | 2014-03-06 |
| 20140065603 | Quantitative Real-Time Assay for Noroviruses and Enteroviruses with Built in Quality Control Standard - A method is provided for reverse transcription-polymerase chain reaction (RT-PCR) comprising a) amplifying a reverse transcribed cDNA in a mixture comprising Norovirus Genogroup I and Norovirus Genogroup II primers and probes, wherein said Norovirus primers and probes distinguish between Genogroup I and Genogroup II viruses; b) quantifying virus; and c) normalizing data based on a universal internal RNA control. Optionally, the method may also include primers and probes for Enteroviruses. A reaction mixture comprising Norovirus Genogroup I and Norovirus Genogroup II primers and probes, wherein said Norovirus primers and probes distinguish between Genogroup I and Genogroup II viruses and universal internal RNA control primers and probes are also included. | 2014-03-06 |
| 20140065604 | METHODS AND SYSTEMS FOR SEQUENCING LONG NUCLEIC ACIDS - The present invention provides methods and systems for sequencing long nucleic acid fragments. | 2014-03-06 |
| 20140065605 | METHODS AND COMPOSITIONS FOR LABELING NUCLEIC ACIDS - The present invention relates to methods for the labeling of nucleic acid polymers in vitro and in vivo. Certain methods are provided that include a [3+2] cycloaddition between a nucleotide analogue incorporated into a nucleic acid polymer and a reagent attached to a label. Other methods are provided that include a Staudinger ligation between a nucleotide analogue incorporated into a nucleic acid polymer and a reagent comprising a substituted triarylphosphine attached to a label. Such methods do not require fixation and denaturation and therefore can be applied to the labeling of nucleic acid polymers in living cells and in organisms. Also provided are methods for measuring cellular proliferation. In these methods, the amount of label incorporated into the DNA is measured as an indication of cellular proliferation. The methods of the invention can be used in a wide variety of applications including clinical diagnosis of diseases and disorders in which cellular proliferation is involved, toxicity assays, and as a tool for the study of chromosomes' ultrastructures. | 2014-03-06 |
| 20140065606 | Compositions, Apparatus and Methods for Monitoring Biomarkers - A single device to collect, transfer, and measure salivary nitric oxide analyte and metabolite, nitrite, a biomarker for nitric oxide, as well as, a method to assess the effects of diet and exercise on changing an individual's nitric oxide status and health. | 2014-03-06 |
| 20140065607 | PHOSPHOLINK NUCLEOTIDES FOR SEQUENCING APPLICATIONS - The present invention provides labeled phospholink, nucleotides that can be used in place of naturally occurring nucleotide triphosphates or other analogs in template directed nucleic acid synthesis reactions and other nucleic acid reactions and various analyses based thereon, including DNA sequencing, single base identification, hybridization assays, and others. | 2014-03-06 |
| 20140065608 | METHOD FOR THE ENUMERATION OF MAMMALIAN MICRONUCLEATED ERYTHROCYTE POPULATIONS, WHILE DISTINGUISHING PLATELETS AND/OR PLATELET-ASSOCIATED AGGREGATES - A method for the enumeration of micronucleated erythrocyte populations while distinguishing platelet and platelet-associated aggregates involves the use of a first fluorescent labeled antibody having binding specificity for a surface marker for reticulocytes, a second fluorescent labeled antibody having binding specificity for a surface marker for platelets, and a nucleic acid staining dye that stains DNA (micronuclei) in erythrocyte populations. Because the fluorescent emission spectra of the first and second fluorescent labeled antibodies do not substantially overlap with one another or with the emission spectra of the nucleic acid staining dye, upon excitation of the labels and dye it is possible to detect the fluorescent emission and light scatter produced by the erythrocyte populations and platelets, and count the number of cells from one or more erythrocyte populations in said sample. In particular, the use of the second antibody prevents interference by platelet-associated aggregates in the scoring procedures. | 2014-03-06 |
| 20140065609 | VARIETAL COUNTING OF NUCLEIC ACIDS FOR OBTAINING GENOMIC COPY NUMBER INFORMATION - A method for obtaining from genomic material genomic copy number information unaffected by amplification distortion, comprising obtaining segments of the genomic material, tagging the segments with substantially unique tags to generate tagged nucleic acid molecules, such that each tagged nucleic acid molecule comprises one segment of the genomic material and a tag, subjecting the tagged nucleic acid molecules to polymerase chain reaction (PCR) amplification, generating tag associated sequence reads by sequencing the product of the PCR reaction, assigning each tagged nucleic acid molecule to a location on a genome associated with the genomic material by mapping the subsequence of each tag associated sequence read corresponding to a segment of the genomic material to a location on the genome, and counting the number of tagged nucleic acid molecules assigned to the same location on the genome having a different tag, thereby obtaining genomic copy number information unaffected by amplification distortion. | 2014-03-06 |
| 20140065610 | METHOD FOR PREDICTING CLINICAL BENEFIT IN THE TREATMENT OF NEURODEVELOPMENTAL, NEUROLOGICAL OR NEUROPSYCHIATRIC DISORDERS - An in vitro method of predicting whether a patient, having a neurodevelopmental, neurological or neuropsychiatric disorder, will derive a clinical benefit if treated with a glycine reuptake inhibitor (GRI), via determination of the protein concentration of one, two, three, four five or six members of the complement factor H family or a mixture or a combination thereof and comparison against a representative value, wherein a higher value of the protein concentration in the patient's sample against the representative value is indicative of a patient whom will derive clinical benefit from treatment with GRI. | 2014-03-06 |
| 20140065611 | MODIFICATION OF NEUROBEHAVIORAL EFFECTS OF MERCURY BY A GENETIC POLYMORPHISM OF COPROPORPHYRINOGEN OXIDASE IN CHILDREN - In one aspect, the present invention provides a method and reagents for predicting a subject's susceptibility or risk to developing a neurobehavioral deficit associated with mercury exposure. The method comprises performing an assay to determine the presence or absence of a CPOX4 polymorphism in one or both alleles of the coproporphyrinogen oxidase (CPOX) gene, and classifying the susceptibility of the subject to developing a neurobehavioral deficit associated with mercury exposure. A subject determined to possess the CPOX4 polymorphism in at least one allele of the CPOX gene is classified as having an increased susceptibility to developing at least one neurobehavioral deficit associated with mercury exposure compared to a subject with no CPOX4 polymorphisms. | 2014-03-06 |
| 20140065612 | METHOD FOR IN VITRO DETECTING KERATIN GENE FUSION OF SQUAMOUS-CELL CANCER - A method for in vitro detecting keratin gene fusion of squamous-cell cancer comprises steps: (a) obtaining a sample of squamous cells from a testee; and (b) detecting whether the sample of squamous cells has gene fusion, which is likely to occur in squamous-cell cancer and unlikely to occur in healthy tissue. The sample of squamous cells is determined to have squamous-cell cancer if the gene fusion exists in the sample of squamous cells. | 2014-03-06 |
| 20140065613 | Multiplex Y-STR Analysis - Novel Y-STR multiplex analysis designs, primer design, allelic ladders, methods of use and kits are disclosed, including the use of primer sets designed to provide amplicons for at least 11 Y-STR loci having a base pair size of less than about 220 bp, as well as the use of primer sets designed to provide amplicons for at least 22 Y-STR loci including at least 5 rapidly mutating loci. | 2014-03-06 |
| 20140065614 | ESTROGEN RECEPTOR ALLELES THAT ARE PREDICTIVE OF INCREASED SUSCEPTIBILITY TO BONE FRACTURE - In one aspect, the present invention provides methods of determining susceptibility to bone fracture in a mammalian subject, wherein the methods comprise analyzing nucleic acid molecules obtained from the mammalian subject to determine which of the P, p X, and x alleles of the estrogen receptor α gene are present, wherein the presence of a haplotype comprising the p and x alleles is indicative of an increased susceptibility to bone fracture. The present invention also provides kits for determining susceptibility to bone fracture in a mammalian subject. | 2014-03-06 |
| 20140065615 | The KRAS Variant and Tumor Biology - The disclosure provides methods for identifying a subject at risk of developing cancer, predicting the onset of cancer, and predicting a subject's response to chemotherapy/treatment by determining the presence or absence of a SNP in the KRAS oncogene, known as the KRAS variant. | 2014-03-06 |
| 20140065616 | Isoltation of Factors Associated with Nucleic Acid - Methods for screening and isolating peptide, polypeptide, protein complexes and non-coding nucleic acids that are associated with selected target genomic locus are provided. The methods comprise the steps of obtaining a sample that comprises a modified target genomic DNA sequence and one or more peptide, polypeptide, protein complexes and non-coding nucleic acids as with that DNA sequence. The target genomic locus DNA sequence which contain all the elements that enable it keeping its function independently in spite of their genomic position are modified by introducing one or more labeling and cutting sequences. These modified target genomic locus DNA sequences are amplified and purified. The purified modified target genomic locus DNA sequences are introduced into cells or animals and their functions are regulated as the same as original endogenous target genomic locus. The modified target sequence and the factors associated with it are crosslinked and selectively isolated. | 2014-03-06 |
| 20140065617 | COMPOSITIONS AND METHODS FOR DETECTING BV-ASSOCIATED BACTERIAL NUCLEIC ACID - Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of a 16S rRNA or its encoding gene from bacterial species associated with bacterial vaginosis. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits. | 2014-03-06 |
| 20140065618 | METHOD FOR DETECTING A CHROMOSOMAL ABERRATION - The invention relates to a method for detecting several different chromosomes or DNA regions in a cell in order to provide evidence for structural chromosomal aberrations, wherein the chromosomal aberrations have at least two breaking point regions within a chromosome, on the basis of directly or indirectly labeled nucleic acid fragments (probes), wherein: a first probe labeled with label A (probe A) and a second probe labeled with label B (probe B) flank a breaking point region | 2014-03-06 |
| 20140065619 | MARKER SET OF HIF-1alpha, HDAC3 AND WDR5 FOR PREDICTING METASTASIS AND SURVIVAL OF CANCERS - In the present invention, the mechanisms to coordinately regulate EMT marker genes during EMT and the interplay between these chromatin modifiers were examined. According to the experimental results, a set of marker consisting of HIF-1α, HDAC3, and WDR5 is provided to predict prognosis or overall survival of cancer patients. By determining if the set markers are co-expressed in a biological sample, it can reach relatively higher predictability of prognosis situation or overall survival as compared with the current markers. | 2014-03-06 |
| 20140065620 | NUCLEIC ACIDS FOR DETECTING BREAST CANCER - This document provides methods and materials involved in detecting breast cancer. For example, nucleic acids for detecting gene rearrangements (e.g., translocations) associated with breast cancer as well as methods and materials for detecting breast cancer are provided. | 2014-03-06 |
| 20140065621 | METHODS FOR INCREASING FETAL FRACTION IN MATERNAL BLOOD - The invention provides methods of increasing the fetal fraction in maternal blood and plasma. This increase in fetal fraction improves the accuracy and decreases the “no call” rate for prenatal testing that measures fetal DNA in maternal blood. | 2014-03-06 |
| 20140065622 | Device for and Method of Isolating and Analyzing a fraction in a Biological Sample - A device and a method are provided for isolating a fraction in a biological sample. The fraction is bound to solid phase substrate to define a fraction-bound solid phase substrate. The device includes an input zone for receiving the biological sample therein to capture a desired fraction of the biological sample. A force is provided that is generally perpendicular to gravity. The force is movable between a first position adjacent the input zone multiple other positions adjacent various purification, protein analysis, separation and extraction zones. The force captures the fraction-bound solid phase substrate and the fraction-bound solid phase substrate moves from the input zone to the other zones to perform a multi-step assay on the isolated fraction within the device. | 2014-03-06 |
| 20140065623 | Methods and Systems for the Detection of Ricin and Other Ribosome Inactivating Proteins - A device, method, and system for the detection of ribosome inactivating protein activity, including the ricin toxin, in a sample. According to one embodiment, the ribosome inactivating protein in the sample removes an adenine from a labeled DNA substrate to create an abasic site. An AP lyase can then cleave the DNA substrate at the abasic site, allowing the fluorophore located at or near one end of the DNA substrate and the quencher at or near the other end of the DNA substrate to spatially separate. Once the fluorophore and the quencher are sufficiently separated, the fluorophore will emit a fluorescence signal. Increasing fluorescence, indicating ribosome inactivating protein activity, will be monitored in real time using a detection system. | 2014-03-06 |
| 20140065624 | Analyzing Messenger RNA and Micro RNA in the Same Reaction Mixture - The present teachings provide methods, compositions, and kits for performing primer extension reactions on at least two target polynucleotides in the same reaction mixture. In some embodiments, a reverse transcription reaction is performed on a first target polynucleotide with a hot start primer comprising a self-complementary stem and a loop, and extension products form at high temperatures but extension products form less so at low temperatures since the self-complementary stem of the hot start primer prevents hybridization of the target specific region to the target. However, non-hot start primers with free target specific regions can hybridize to their corresponding targets at the low temperature and extension can happen at the low temperature. | 2014-03-06 |
| 20140065625 | Isotopically-Labeled Proteome Standards - The invention provides methods for quantifying biomolecules, such as polypeptides in mass spectrometric analysis. The methods include use of a biomolecule standard having at least one atomic isotope different than that of the naturally occurring isotopes in the biomolecule of interest. Methods of the present invention also include methods for quantifying biomolecules where the copy biomolecule standard is made by expressing the biomolecule using a recombinant cell. Further included are the biomolecule standards themselves, method for making such standards, kits, systems, reagents, and engineered cells relating to the use of biomolecule standards in mass spectrometric analysis. | 2014-03-06 |
| 20140065626 | COMPOSITIONS AND METHODS OF SELECTIVE NUCLEIC ACID ISOLATION - The invention relates to methods for isolating and/or identifying nucleic acids. The invention also provides kits for isolating and/or identifying nucleic acids. | 2014-03-06 |
| 20140065627 | COMPOSITIONS AND METHODS FOR BIOLOGICAL SAMPLE STORAGE - Compositions and methods are disclosed for substantially dry storage at ambient or elevated temperatures of biological samples such as nucleic acids, proteins and cells in a form from which the samples can be substantially recovered, using a dissolvable or dissociable dry storage matrix comprising a borate composition and a stabilizer as disclosed, such as any of a number of zwitterionic stabilizers. | 2014-03-06 |
| 20140065628 | Methods and Devices for Multi-Color, Out-of-Phase Detection in Electrophoresis - The disclosure provides methods and devices for separating and detecting nucleic acid fragments labeled with a plurality of spectrally resolvable dyes using a single light source or multiple light sources. Use of a greater number of light sources increases the number of spectrally resolvable dyes that can be interrogated. Labeling fragments with a greater number of spectrally resolvable dyes permits more overlapping of fragments with differentiation of the fragments, and thus separation can be conducted on a smaller range of fragment sizes/lengths. To improve the detection sensitivity of a detection system employing multiple light sources, light emitted by the light sources can be spatially separated from one another and/or the intensity of each of the light sources can be modulated. Each of the one or more light sources can be, e.g., a laser or a light-emitting diode. The methods and devices of the disclosure are useful for performing genetic analysis, e.g., analysis of a plurality of STR markers utilized in a forensic database (e.g., CODIS) to identify humans. | 2014-03-06 |
| 20140065629 | METHODS OF TREATING DISEASES - In one example, the present invention comprises deliberate tumor insult and sequencing of the T cell repertoire before and after the insult in order to detect and sequence the TCR alpha and beta loci of highly expanded T cell clonotypes. In some examples, this information is used in turn to create autologous genetically engineered T cells with TCR sequences that target the individual's tumor. | 2014-03-06 |
| 20140065630 | METHODS AND COMPOSITIONS FOR DIAGNOSING GASTROINTESTINAL STROMAL TUMORS - The present invention relates to an in vitro method for diagnosing and/or monitoring in a subject a gastrointestinal stromal tumor or a predisposition to develop a gastrointestinal stromal tumor, comprising detecting and/or analyzing in a test sample derived from the subject one or more mutations at the DNA level in any one or both of the marker genes cKIT (GenBank acc. no. NM_000222.2) and PDGFRA (GenBank acc. no. NM_006206.4), wherein the DNA is circulating DNA, and wherein the presence of any one of the mutations detected in the test sample is indicative of a gastrointestinal stromal tumor or a predisposition to develop a gastrointestinal stromal tumor in the subject. The present invention is also directed to a corresponding kit-of-parts for diagnosing and/or monitoring a gastrointestinal stromal tumor or a predisposition to develop a gastrointestinal stromal tumor, comprising means for detecting and/or analyzing one or more mutations as defined herein, as well as to the use of one or more mutations as defined herein as a panel of molecular markers for diagnosing and/or monitoring a gastrointestinal stromal tumor or a predisposition to develop a gastrointestinal stromal tumor. | 2014-03-06 |
| 20140065631 | Microfluidic Chip, Device and System for the Generation of Aqueous Droplets in Emulsion Oil for Nucleic Acid Amplification - A microfluidic chip, device, system, the use thereof and method for the generation of aqueous droplets in emulsion oil for nucleic acid amplification. | 2014-03-06 |
| 20140065632 | MARKER GENE FOR DETECTION OF TUMOR PROMOTER, AND METHOD FOR DETECTION OF TUMOR PROMOTER - The present invention provides 27 marker genes comprising Orm1, Scarb1, Stmn1, Rad21, Nup54, Jun, Dmp1, Abi1, 6530403A03Rik, Slc2a1, Plf (Plf2, Mrpplf3), Fosl1, Chek1, Pik3r5, JunB, Vegfa, Rif1 (LOC671598), Il1rl1, Phex, Tfrc, Zfhx1b, Rad51ap1, Hells, Mcm3, Orm2, Car13 and Ccnb1, which enables the detection of a tumor promoter in a simple manner and within a short period of time in a test for predicting carcinogenicity as a tumor promoter using a cultured cell. The present invention further provide a tumor promoter detection method using at least one of the marker genes. | 2014-03-06 |
| 20140065633 | METHODS FOR DETERMINING THE EFFECTS OF COMPOUNDS ON JAK/STAT ACTIVITY - An embodiment of the present invention is a method for subjecting a hematopoetic cell to a JAK/STAT inhibitor, determining the activity of gain-of-function mutations of a Jak family kinase, determining the expression levels and activity of JAK/STAT regulatory proteins, correlating the expression levels and the activity of JAK/STAT regulatory proteins with the activity of gain-of-function mutations of a Jak family kinase and with a response to the JAK/STAT inhibitor, and then classifying the cells. A further embodiment of the invention includes determining the clinical outcome based on the cell classification, determining a method of treatment, determining dosing and scheduling of at least one of the JAK/STAT inhibitors or other compounds. | 2014-03-06 |
