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10th week of 2014 patent applcation highlights part 54
Patent application numberTitlePublished
20140065032CASE FOR SPECIMEN ANALYZING KIT, KIT FOR SPECIMEN ANALYZING, SPECIMEN ANALYSIS APPARATUS AND CONTROL METHOD OF SPECIMEN ANALYSIS APPARATUS - Provided is a specimen analysis apparatus. The specimen analysis apparatus includes an image photographing unit photographing an identification code disposed on a kit for specimen analyzing and a specimen reaction result reacting by injecting a specimen into the kit for specimen analyzing and a main body on which the image photographing unit is mounted. The image photographing unit photographs the identification code and the specimen reaction result with a time difference.2014-03-06
20140065033CASE FOR SPECIMEN ANALYZING KIT, KIT FOR SPECIMEN ANALYZING, SPECIMEN ANALYSIS APPARATUS AND CONTROL METHOD OF SPECIMEN ANALYSIS APPARATUS - Provided is a case for specimen analyzing kit. The case includes a cover unit comprising a put-in part through which a specimen is putted and a result exposing part exposing a reaction result between the specimen and a reaction pad to the outside, a support unit coupled to the cover unit to define a predetermined inner space, and a plurality of put-in holes passing through the put-in part to introduce the specimen into the inner space.2014-03-06
20140065034MICROFLUIDIC DEVICE AND METHOD OF FABRICATING MICROFLUIDIC DEVICES - Lab-on-a-chip microfluidic devices having micro-channels able to withstand an internal channel pressure of more than 4,000 psi are described. The micro-channels have rounded cross-sections that prevent turbulent flow within a fluid conveyed within the channel. The channel may have serpentine-shaped length extending between a channel inlet and a channel outlet, the channel thereby being of sufficient length to observe both the stationary and moving phases of the fluid in a chip having a sufficiently small footprint that it is suitable for incorporation into a miniaturized spectrometer. Methods of fabricating lab-on-a-chip microfluidic devices are described by etching recesses in chip substrates such that a first substrate recess mirrors a second substrate recess in an opposed orientation, aligning the substrates such the recesses cooperatively define a micro-channel having a rounded cross-section, and bonding the substrates to define a smooth-walled micro-channel.2014-03-06
20140065035METHOD FOR MANUFACTURING A MICROVALVE DEVICE MOUNTED ON A LAB-ON-A-CHIP, AND MICROVALVE DEVICE MANUFACTURED BY SAME - The present invention relates to a method for manufacturing a microvalve device of a lab-on-a-chip by interposing a polyvinylidene chloride film between upper and lower substrates, each of which is produced by injection molding of a rigid polymer resin, and heating and pressurizing the resultant structure. The present invention also relates to a microvalve device manufactured by the method. According to the method of the present invention, each of the upper and lower substrates can be produced by injection molding of a rigid polymeric material, thus being appropriate for mass production in a short time. Excellent thermal bonding properties between the polyvinylidene chloride film and the substrates enable the formation of the rigid substrate/film membrane/rigid substrate structure in an easy and reliable manner, which shortens the time required to manufacture the microvalve device. Therefore, the method of the present invention is suitable for the mass production of labs-on-a-chip. In addition, the polyvinylidene chloride film does not droop upon thermal pressing due to its thermal shrinkage. Therefore, the polyvinylidene chloride film does not fill a fine shape and the shape thereof remains unchanged. The shape of the film membrane is curved by the application of a vacuum, which ensures smooth and sensitive opening/closing operations. The polyvinylidene chloride film prevents mixing of fluids flowing on and under the film membrane due to its low fluid permeability. Therefore, the polyvinylidene chloride film is suitable as a valve or pump.2014-03-06
20140065036Tray Support for Chromatographic Equipment - A universal tray holder assembly on a CTC prep and load instrument is disclosed. The assembly contains sample tray and a tray support block attached directly to the sample tray, support legs attached to the tray support block at a first edge of the support legs, and clamps attached to the support leg at a second edge that is distal to the first edge. The sample tray is reversibly detachable from the tray support block when the clamps are attached to the x-beam rail, and removal and subsequent replacement of the sample tray onto the support block results in no change in the x and y positions of any sites on the sample tray relative to the positions before tray removal. The invention saves time during installation and removal because the operator does not need access to the back of the chromatograph instrument. Positions do not need to be re-taught if access to underneath the sample tray is needed. Trays can be changed without the need for purchasing a different tray holder.2014-03-06
20140065037TREATMENT OF INDIUM GALLIUM ALLOYS AND RECOVERY OF INDIUM AND GALLIUM - There is provided a hydrometallurgical process of recovering indium and gallium values from mixtures thereof with other metal values for example recycled and scrap solar panel cells which comprises subjecting the mixture to strongly oxidizing acid conditions, preferably via the simultaneous addition of sulfuric acid and hydrogen peroxide to the leach vessel, so as to form indium and gallium salt species of at least the major proportion of the indium and gallium values in the mixture, extracting the indium and gallium values with an organic extractant by adjusting the pH so as to extract individually the indium and gallium values with the organic extractant, stripping indium and gallium values from the extractant using an acid and an alkaline solution respectively and recovering the indium and gallium values.2014-03-06
20140065038PROCESSES FOR EXTRACTING ALUMINUM FROM ALUMINOUS ORES - There are provided processes for extracting aluminum ions from aluminous ores and for preparing alumina. Such processes can be used with various types of aluminous ores such as aluminous ores comprising, for example, various types of metals such as Fe, K, Mg, Na, Ca, Mn, Ba, Zn, Li, Sr, V, Ni, Cr, Pb, Cu, Co, Sb, As, B, Sn, Be, Mo, or mixtures thereof.2014-03-06
20140065039Extraction of alkali metals and/or alkaline earth metals for use in carbon sequestration - A method of extracting an alkali metal and/or an alkaline earth metal from a mineral including an alkali metal and/or an alkaline earth metal, or a rock containing the mineral, the method including contacting the mineral, with an aqueous composition including formic acid, and to their use in carbon sequestration.2014-03-06
20140065040PROCESS FOR SEPARATING OFF ACID GASES FROM A WATER-COMPRISING FLUID STREAM - A process for separating off acid gases from a water-comprising fluid stream wherein the water-comprising fluid stream is contacted in an absorption zone with an absorbent, producing a deacidified fluid stream and an acid gas-loaded absorbent; the deacidified fluid stream is contacted in a scrubbing zone with an aqueous scrubbing liquid, producing a deaminated, deacidified fluid stream and an amine-loaded scrubbing liquid which is cooled, producing an absorber top condensate; the loaded absorbent is passed into a desorption zone producing a regenerated absorbent and desorbed acid gases; the regenerated absorbent is returned to the absorption zone in order to form an absorbent circuit, to which the amine-loaded scrubbing liquid and the absorber top condensate are introduced; and the desorbed acid gases are conducted through an enrichment zone and the acid gases exiting at the top of the enrichment zone are cooled, producing a desorber top condensate.2014-03-06
20140065041EMISSIONS AFTERTREATMENT COMPONENT RECOVERY SYSTEM AND METHOD - Methods and systems include an operation to interpret a face-plugging index and/or a reduction in an expected oxidation efficiency of an oxidation catalyst disposed in an internal combustion engine aftertreatment system, and in response to the face-plugging index or the reduction oxidation efficiency reaching a threshold value, an operation to provide a catalyst element reversal command.2014-03-06
20140065042THREE WAY CATALYST COMPRISING EXTRUDED SOLID BODY - A three way catalyst includes an extruded solid body having by weight: 10-100% of at least one binder/matrix component; 5-90% of a zeolitic molecular sieve, a non-zeolitic molecular sieve or a mixture of any two or more thereof; and 0-80% optionally stabilised ceria. The catalyst also includes at least one precious metal and optionally at least one non-precious metal, wherein: (i) the at least one precious metal is carried in one or more coating layer(s) on the body surface; (ii) at least one metal is present throughout the body and at least one precious metal is carried in one or more coating layer(s) on a body surface; or (iii) at least one metal is present throughout the body, is present in a higher concentration at a body surface, and at least one precious metal is carried in one or more coating layer(s) on the body surface.2014-03-06
20140065043OXIDATION CATALYST FOR EXHAUST GAS PURIFICATION, METHOD FOR PRODUCING THE SAME, AND EXHAUST GAS PURIFICATION METHOD USING THE SAME - The purpose of the present invention is to provide an oxidation catalyst for exhaust gas purification having high durability and a method for producing the catalyst. The purpose is achieved by an oxidation catalyst for exhaust gas purification containing a refractory inorganic oxide, and a catalyst component and a metal component, which are supported on the refractory inorganic oxide, wherein the catalyst component is platinum, or platinum and palladium, and the metal component is one or more selected from the group consisting of magnesium, calcium, strontium and barium.2014-03-06
20140065044AMMONIA OXIDATION CATALYST, EXHAUST GAS PURIFICATION DEVICE USING SAME, AND EXHAUST GAS PURIFICATION METHOD - Ammonia oxidation catalyst being superior in heat resistance and capable of suppressing by-production of N2014-03-06
20140065045PROCESSES FOR SELECTIVELY REDUCING THE CONCENTRATION OF HYDROGEN CYANIDE IN SYNGAS - This invention pertains to processes for selectively oxidizing hydrogen cyanide contained in syngas using permanganate anion as an oxidant contained in an aqueous solution that is contacted with the syngas under certain conditions of temperature, pressure and duration of contact.2014-03-06
20140065046DESULPHURIZATION AND COOLING OF PROCESS GAS - The present invention relates to a method of cleaning a process gas containing sulphur dioxide the method including removing sulphur dioxide from the process gas by contacting the process gas with seawater to generate an at least partly cleaned process gas in a first gas cleaning device. In a second gas cleaning device, being arranged in direct fluid connection with the first gas cleaning device, the at least partly cleaned process gas having passed through the first gas cleaning device is cooled to condense water there from, thereby generating a process gas having a reduced content of water vapour. At least a part of the condensed water generated in the second gas cleaning device is passed to the first gas cleaning device. The present invention moreover relates to a gas cleaning system for cleaning of a process gas containing sulphur dioxide.2014-03-06
20140065047GAS TREATMENT BY CATALYTIC OZONE OXIDATION - In one embodiment, a catalyst for ozone oxidation of pollutant components dispersed in a gas is provided. The ozone oxidation catalyst has a porous body formed from a metal body, a ceramic, or polymeric fibers coated with metal. A catalytic noble metal composition is deposited on the surface of the porous body. The catalytic noble metal composition is formed from particles of a noble metal supported by a mesoporous molecular sieve.2014-03-06
20140065048CARBON NANOTUBE ARRAY - A carbon nanotube array suitable for use in labeling is provided. The carbon nanotube array includes at least two different isotope-doped carbon nanotube sub-arrays. Each isotope-doped carbon nanotube sub-array includes a plurality of carbon nanotubes. The carbon nanotubes in different isotope-doped carbon nanotube sub-arrays are composed of different kinds of carbon isotopes.2014-03-06
20140065049INTERNAL CYCLONE FOR FLUIDIZED BED REACTOR - A fluidized bed reactor comprising a reaction column having a fluid portion; a gas inflow means for flowing a gas upwardly from the fluid portion of the reaction column; a particle feed means for feeding particles to the fluid portion of the reaction column; a cyclone capable of separating particles from the gas flowing upwardly from the fluid portion of the reaction column, the cyclone being located within the reaction column and being in communication with the gas flowing upwardly, wherein the cyclone comprises a cyclone body having an inlet, a gas outlet, and a particle drop port; and a particle discharge pipe having an upper part connected to the particle drop port of the cyclone body, and a lower part, wherein the particle discharge pipe is located substantially outside of the reaction column.2014-03-06
20140065050SYSTEMS, METHODS AND COMPOSITIONS FOR THE PRODUCTION OF SILICON NITRIDE NANOSTRUCTURES - Systems, methods and compositions for the production of silicon nitride nanostructures are herein disclosed. In at least one embodiment, a carbon feedstock is preprocessed, combined with a silicon feedstock and annealed in the presence of a nitrogen containing compound to produce a silicon nitride nanostructure.2014-03-06
20140065051METHOD FOR MANUFACTURING SILICON CARBIDE POWDER - A method for revitalizing worn and fatigued silicon carbide powder thermally reacted it continuously with a mixture of silicon oxide powder and/or carbon powder and a boron and carbon-containing additive in a non-oxidizing atmosphere at a temperature higher than 1850 degrees C. but lower than 2400 degrees C.2014-03-06
20140065052PROCESS FOR MANUFACTURING NEEDLE-SHAPED STRONTIUM CARBONATE PARTICLES - Acicular strontium carbonate particles are manufactured by introducing gaseous carbon dioxide into an aqueous solution or suspension of strontium hydroxide having a concentration of 1 to 20 wt. %, at a flow rate of 0.5 to 200 mL/min., relative to one gram of the strontium hydroxide, while stirring the solution or suspension in the presence of a dicarboxylic acid, in which the dicarboxylic acid comprises a divalent linear hydrocarbon group having one to four carbon atoms and carboxyl group bonded to each terminals, with the proviso that the linear hydrocarbon group may be substituted with one or more C2014-03-06
20140065053CARBON DIOXIDE RECOVERY APPARATUS AND METHOD - An apparatus that separates and recovers CO2014-03-06
20140065054MEMBRANE-ENABLED REVERSE LUNG - An air revitalization apparatus and method simultaneously removes carbon dioxide, water vapor, and heat from air and produces oxygen gas, hydrogen gas, and concentrated carbon dioxide gas, does not require an explosion proof enclosure, and includes a fan configured to blow air into a first gas-liquid contactor, an electrochemical cell including first through fourth passages configured to emit hydrogen gas, permit a flow of a carbonate-hydroxide solution, permit a flow of carbonate-bicarbonate solution, and emit oxygen gas, respectively, the first and fourth passages separated by at least three gas-impermeable membranes, and a second gas-liquid contactor, where the first gas-liquid contactor, second passage, and a first pump are configured to circulate the carbonate-hydroxide solution therethrough, where the second gas-liquid contactor, third passage, and a second pump are configured to circulate the carbonate-bicarbonate solution therethrough, and where the output of the first passage is operationally coupled to the second gas-liquid contactor.2014-03-06
20140065055METHOD FOR PRODUCING CARBON MICRO- AND NANO-COILS USING SULFUR HEXAFLUORIDE GAS - The present invention relates to a method for producing carbon micro- and nano-coils using sulfur hexafluoride gas, wherein the carbon micro- and nano-coils are synthesized and grown on a ceramic substrate and sulfur hexafluoride is introduced during the synthesis of the carbon coils to control the geometry of the carbon coils. The invention also discloses a method of producing carbon micro- and nano-coils by synthesizing and growing the carbon coils on a substrate using a chemical vapor deposition system, wherein sulfur hexafluoride (SF2014-03-06
20140065056GRAPHITE MATERIAL FOR NEGATIVE ELECTRODES OF LITHIUM ION SECONDARY BATTERY, MANUFACATURING METHOD FOR SAID MATERIAL, AND LITHIUM ION SECONDARY BATTERY USING SAME - A graphite material for a negative electrode is provided which can suppress capacity degradation due to repeated charging and discharging cycles, storage in a charged state, and floating charging.2014-03-06
20140065057SULFUR DEGASSER APPARATUS AND METHOD - A novel system and method for degassing H2014-03-06
20140065058APPARATUS FOR PREPARING CATHODE ACTIVE MATERIAL PRECURSOR FOR LITHIUM SECONDARY BATTERIES AND METHOD FOR PREPARING THE SAME USING THE APPARATUS - Provided are an apparatus for preparing a cathode active material precursor for lithium secondary batteries including a cylindrical outer chamber, an inner cylinder that has the same central axis as the outer chamber and is mounted to rotatably move along the central axis, an electric motor to transfer power to rotate the inner cylinder, a reactant inlet disposed on the outer chamber, to add reactants to a space between the outer chamber and the inner cylinder, and an outlet disposed in the outer chamber, to obtain reaction products after reaction in the space between the outer chamber and the inner cylinder, and a method for preparing a cathode active material precursor for lithium secondary batteries using the apparatus.2014-03-06
20140065059CATALYST FOR PRODUCING AN OLEFIN FROM AN ALCOHOL, METHOD FOR PRODUCING OLEFIN, POLYOLEFIN, AND OLEFIN OXIDE - Disclosed are a catalyst for producing, from an alcohol, an olefin whose number of carbon atoms is at least one more than the number of carbon atoms of the alcohol, wherein at least the surface of the catalyst is substantially composed of zirconium oxide; a method for producing an olefin using the same; and so on.2014-03-06
20140065060Precursors for Metal Organic Chemical Vapor Deposition Processes and Their Use - The present invention relates to a compound of the general formula (I)2014-03-06
20140065061CURCUMIN-ER, A LIPOSOMAL-PLGA SUSTAINED RELEASE NANOCURCUMIN FOR MINIMIZING QT PROLONGATION FOR CANCER THERAPY - The present invention includes compositions and methods of making a nanoparticle composition comprising a polymeric core comprising one or more polymers and one or more active agents, and at least one layer of one or more lipids on the surface of the polymeric core; more specifically, the invention relates to the use of curcumin within such a lipid-polymer nanoparticle formulation for minimizing QT prolongation associated with curcumin in treatment of cancer.2014-03-06
20140065062Halogenated Di and Trisaccharides, Pharmaceutical Formulations, Diagnostic Kits and Methods of Treatment - The present invention relates to a novel family of alkylated halogenated di- and trisaccharides which exhibit pharmaceutical efficacy in the areas of permeation enhancers, anti-microbial effects, anti-fugal effects, facilitation of diagnostic procedures. The invention further includes methods of treatment and diagnostic kits.2014-03-06
20140065063THERAPEUTIC USE OF ANTI-CS1 ANTIBODIES - The present invention is directed to antagonists of CS1 that bind to and neutralize at least one biological activity of CS1. The invention also includes a pharmaceutical composition comprising such antibodies or antigen-binding fragments thereof. The present invention also provides for a method of preventing or treating disease states, including autoimmune disorders and cancer, in a subject in need thereof, comprising administering into said subject an effective amount of such antagonists.2014-03-06
20140065064MONOCLONAL ANTIBODIES AGAINST ALPHA-ACTININ-4 ANTIGENS, AND USES THEREFOR - Monoclonal antibodies (MoAbs or mAbs) specific for ALPHA-ACTININ-4 antigens, hybridoma lines that secrete these ALPHA-ACTININ-4 mAbs, and the use of such mAbs to detect ALPHA-ACTININ-4 antigens, particularly those expressed by cancer cells are disclosed. Chimeric and humanized antibodies based upon these anti-ALPHA-ACTININ-4 mAbs, processes for producing monoclonal, chimeric, and humanized antibodies using recombinant DNA technology, and their therapeutic uses, particularly in the treatment of cancer are also disclosed. Methods and kits for the immunodetection and immunotherapy of cells for samples which express ALPHA-ACTININ-4 antigens are additionally disclosed.2014-03-06
2014006506599mTc IMAGING AGENTS AND METHODS OF USE - An embodiment of the invention comprises method of imaging a target site comprising administrating ligand of Formula I complexed to 2014-03-06
20140065066IMAGING AND THERAPEUTIC METHOD USING MONOCYTES - The invention relates to a method of treating or diagnosing a disease state mediated by monocytes. The method utilizes a composition comprising a conjugate or complex of the general formula2014-03-06
20140065067RADIOPAQUE IODINATED PRODUCTS INTENDED FOR USE MEDICAL IMAGING AND THEIR METHODS - Iodinated amphiphilic compound of formula (I):2014-03-06
20140065068VITAMIN-TARGETED IMAGING AGENTS - The invention relates to compounds and methods for targeting radionuclide-based imaging agents to cells having receptors for a vitamin, or vitamin receptor binding derivative or analog thereof, by using such a vitamin as the targeting ligand for the imaging agent. The vitamin-based compounds can be used to target radionuclides to cells, such as a variety of tumor cell types, for use in diagnostic imaging of the targeted cells.2014-03-06
20140065069Materials and Methods Relating to Cardiovascular Imaging - The invention provides conjugates for imaging plaques, such as cardiovascular plaques, as well as associated pharmaceutical compositions. Other aspects of the invention include methods for administering and imaging such conjugates and compositions, and using the imaging to characterise plaques. The conjugates of the invention distinguish between tropoelastin and elastin in plaques. The presence of tropoelastin can act as an indication that a plaque is liable to rupture or erode. Such information allows assessment of disease progression and response to treatment.2014-03-06
20140065070METHODS OF PREPARING TRIAZOLE-CONTAINING RADIOIODINATED COMPOUNDS - The present application relates to methods of preparing radiohalogenated compounds, to compounds useful in such methods and to radiohalogenated compounds useful for imaging and/or therapy. In particular, the present application relates to methods of preparing radiohalogenated compounds of Formula I, to compounds useful in such methods and to radiohalogenated compounds of Formula I:2014-03-06
20140065071Sincalide Formulations - The invention features sincalide formulations that include an effective amount of sincalide, a bulking agent/tonicity adjuster, a stabilizer, a surfactant, a chelator, and a buffer. The invention also features kits and methods for preparing improved sincalide formulations as well as methods for treating, preventing, and diagnosing gall bladder-related disorders using sincalide formulations.2014-03-06
20140065072Modulation of Telomere Length in Telomerase Positive Cells and Cancer Therapy - Induction of telomere shortening, G2 arrest and apoptosis in telomerase positive cancer cells using acyclic nucleoside analogs has been disclosed. In addition, methods for impairment or prevention of tumorigenic telomerase positive cells from having a chance to grow into a tumor and methods for promoting tumor regression (decrease in size of an established tumor) using acyclic nucleoside analogs has been disclosed.2014-03-06
20140065073IMAGING AGENTS AND METHODS OF USE THEREOF - Compositions and methods useful in connection with magnetic resonance imaging are provided. Metabolites hyperpolarized by dynanic nuclear polarization are used as reporter molecules in nuclear magnetic resonance (“NMR”) spectroscopy to study metabolic pathways and diagnose disease states. The reporter molecules include hyperpolarized glutamine and hyperpolarized acetate. The invention includes the reporter molecules, compositions including the reporter molecules in pharmaceutically acceptable carriers, methods for studying metabolic pathways that include introducing one or more of the reporter molecules to a mammalian subject and imaging a target substance using NMR spectroscopy, and kits useful in studying metabolic pathways that incorporate one or more of the reporter molecules and instructions for their use.2014-03-06
20140065074METHOD OF TRACKING GROWTH AND METASTASIS OF SPECIFIC CELLS IN VIVO - A method of tracking growth and metastasis of specific cells in vivo is disclosed. The method of the disclosure includes culturing the specific cells in a medium containing 0.1 μM to 10 mM nanoparticles as a biomarker for X-rays, such that the specific cells carry the nanoparticles, administering the specific cells carrying the nanoparticles to a subject, irradiating the subject by an X-ray source, and determining the growth and metastasis of the specific cells by X-ray images of the nanoparticles in the subject.2014-03-06
20140065075TARGETED CONTRAST AGENTS AND USES THEREOF - Described herein is a contrast agent for administration to a subject. The contrast agent includes a targeting portion that includes an unchelated aminocarboxylate functional group; a metal ion bound to a metal-complexable portion; and a linker joining the targeting portion and the metal-complexable portion of the contrast agent. The portion that is not bound to a metal ion is for binding to necrotic tissue in the subject.2014-03-06
20140065076CONTAINER WITH CONCENTRATED SUBSTANCE AND METHOD OF USING THE SAME - Apparatus and methods are described herein for a container with a unit dose of a concentrated substance that can be diluted and orally consumed using the container. In some embodiments, an apparatus includes a container body that defines an opening in fluid communication with an interior of the container body. A cap is coupled to the container body and encloses the opening. A unit dose of a concentrated medicament or a concentrated contrast agent is disposed within the interior of the container body. The unit dose of concentrated medicament or contrast agent can be diluted to a select dilution strength with a volume of a liquid receivable through the opening and within the interior of the container body. In some embodiments, the apparatus can include a barrier member in which the container body and cap can be disposed to protect the medicament or contrast agent from light and/or moisture.2014-03-06
20140065077CONTAINER WITH CONCENTRATED SUBSTANCE AND METHOD OF USING THE SAME - Apparatus and methods are described herein for a container with a unit dose of a concentrated substance that can be diluted and orally consumed using the container. In some embodiments, an apparatus includes a container body that defines an opening in fluid communication with an interior of the container body. A cap is coupled to the container body and encloses the opening. A unit dose of a concentrated medicament or a concentrated contrast agent is disposed within the interior of the container body. The unit dose of concentrated medicament or contrast agent can be diluted to a select dilution strength with a volume of a liquid receivable through the opening and within the interior of the container body. In some embodiments, the apparatus can include a barrier member in which the container body and cap can be disposed to protect the medicament or contrast agent from light and/or moisture.2014-03-06
20140065078ORAL CARE COMPOSITION FOR PROMOTING AND MAINTAINING ORAL HEALTH AND METHOD OF FORMING AND USING SAME - An oral care composition, a method of forming the oral care composition, and a method of using the oral care composition are disclosed. The oral care composition includes a plurality of enzymes to prevent formation of and/or facilitate the breakup of biofilm in an oral cavity and a metal ion management system to inhibit growth of gram negative bacteria.2014-03-06
20140065079METHOD FOR DE-COLORING SHELLAC, DE-COLORED SHELLAC, COMPOSITIONS COMPRISING SAME, AND USES THEREFOR - A method for producing de-colored shellac by dissolving colored shellac in an aqueous solution comprising an alkaline agent; contacting the colored shellac in the aqueous solution with a sufficient amount of a chlorite salt to achieve de-coloration of the shellac; precipitating the de-colored shellac by neutralizing the aqueous solution with an acid; and recovering the precipitated de-colored shellac from said aqueous solution. The de-colored shellac produced is non-toxic and suitable for human use. Dental compositions comprising the de-colored shellac are disclosed, as well as uses of the de-colored shellac as a food product coating, a nail polish or varnish, and a wood varnish.2014-03-06
20140065080ORAL CARE COMPOSITIONS - Described herein are oral compositions comprising an extract obtained from Arialaceae, Zingiberaceae, Lamiaceae, Fabaceae, Solanaceae, Punicaceae. Asteraceae or mixtures thereof; Their uses for alleviating dry mouth is also described.2014-03-06
20140065081FUNCTIONAL FRAGRANCE PRECURSOR - The present invention relates to a class of fragrance precursor compounds comprising one or more of the compounds derived from the reaction of X—OH and an aldehyde or ketone, said fragrance precursor compounds being of the formula X—O—C(R)(R*)(OR**) wherein R is a C2014-03-06
20140065082Topical skin care formulations - A white, color-stable anti-aging emulsion formula containing CoQ10 and/or vanillin. The amount of vanillin can be adjusted to provide light or dark tanning of the skin. Lime oil and lime juice form a preferred emulsion foundation.2014-03-06
20140065083TOPICAL SKIN CARE FORMULATIONS COMPRISING PLANT EXTRACTS - Disclosed are topical skin compositions and corresponding methods of their use that include an extract from 2014-03-06
20140065084SOLID COSMETIC MAKEUP AND/OR CARE COMPOSITION - The present invention relates to a cosmetic composition for making up and/or caring for keratin materials, in the form of an oil-in-water solid emulsion, comprising, in a physiologically acceptable medium: —from 4.0% to 8.0% by weight, relative to the total weight of the composition, of at least one fatty alcohol, —from 1.0% to 3.0% by weight, relative to the total weight of the composition, of at least one solid linear ester, —from 2.5% to 6.0% by weight, relative to the total weight of the composition, of at least one non-ethoxylated glyceryl stearate, and —from 0.25% to 0.50% by weight, relative to the total weight of the composition, of sodium polyacrylate.2014-03-06
20140065085Topical skin care formulations - A white, color-stable, stain-free emulsion formulation containing vanillin for sunless tanning. The amount of vanillin can be adjusted, from about 1% up to about 45%, to provide light or dark tanning of the skin. Lime oil and lime juice form a preferred white emulsion foundation.2014-03-06
20140065086Dickkopf-1 Expression Modulating Compositions and Uses Thereof - The present invention relates generally to compositions for topical application to the skin which comprise at least one DICKKOPF-1 expression modulator and the use of such compositions to provide benefits to the skin, including but not limited to lightening or darkening skin; treating hyper or hypopigmented skin; increasing or decreasing skin thickness; reducing or increasing skin hirsuteness; and/or changing skin phenotype from non-palmoplantar to palmoplantar.2014-03-06
20140065087Preservative Mixtures and Polymer Solutions Stabilized Therewith - Aqueous polymer solutions are described which have been stabilized with a preservative mixture of 0.01 to 0.2% by weight of ethylhexylglycerol, 0.001 to 0.01% by weight of 2-methylisothiazolinone and 0.05 to 0.5% by weight of phenoxyethanol. The stabilized polymer solutions are suitable for cosmetic preparations, such as skincare and hair care compositions, products of decorative cosmetics and cosmetic cleaning products.2014-03-06
20140065088COMBINED STABLE CATIONIC AND ANIONIC SURFACTANT COMPOSITIONS - Aqueous free-flowing surfactant compositions having non-Newtonian shear thinning properties are disclosed. These stable compositions include both cationic and anionic surfactants and can suspend water-insoluble particles or partially insoluble components.2014-03-06
20140065089HYDRATING COMPOSITION - The present invention is directed to a composition for hydrating keratinous substrates such as skin, hair and nails, the composition containing: (a) greater than 10% by weight of glycerin; (b) at least one C3-C8 alkanediol, other than glycerin; (c) an emollient mixture comprising shea butter and squalane; (d) at least one surfactant; and (e) water, all weights based on the total weight of the composition.2014-03-06
20140065090Reactive Oxidative Species Generating Materials and Methods of Use - Materials capable of delivering stabilized free radicals to targeted treatment sites. The materials comprise semi-crystalline, hydrolytically degradable polymers that are subjected to ionizing radiation to create stabilized free radicals therein. Upon exposure to oxygen containing aqueous media, the materials generate reactive oxidative species which are useful in biological processes.2014-03-06
20140065091MEDICAL ADHESIVE FOR STEMMING BLEEDING - The present invention relates to a polyurea system comprising as component A) isocyanate-functional prepolymers obtainable by reaction of aliphatic isocyanates A1) with polyols A2), which in particular can have a number-average molecular weight of ≧400 g/mol and a mean OH functionality of from 2 to 6, as component B) an amino-functional compound of the general formula (I) in which X is an organic radical containing a secondary amino function, Y is an organic radical that contains a tertiary amino group and does not contain Zerewitinoff-active hydrogen, R2014-03-06
20140065092Yarns, fibers or filaments, textile article, and medical device obtained from said yarns for skin cicatrization - The subject of the present invention is yarns, fibers or filaments and also a textile article and a medical device obtained from said yarns, for improving skin cicatrization, in particular by activating collagen synthesis at the surface of the injured skin. The yarns, fibers or filaments of the invention comprise a polymeric matrix and inorganic fillers, uniformly dispersed in the polymeric matrix, having properties of absorption and/or of emission in the 2-20 μm far-infrared region.2014-03-06
20140065093Compositions For Achieving A Therapeutic Effect In An Anatomical Structure - Compositions and methods of using the compositions are provided for forming an embolus within a region of an anatomical lumen for a transitory period in order to achieve a therapeutic effect.2014-03-06
20140065094POLYMER CONJUGATES OF BOX-A OF HMGB1 AND BOX-A VARIANTS OF HMGB1 - The present invention relates to novel polymer conjugates of polypeptide variants of the HMGB1 high affinity binding domain Box-A (HMGB1 Box-A) or of a biologically active fragment of HMGB1 Box-A. Further, the invention relates to novel polymer conjugates of polypeptide variants of the HMGB1 high affinity binding domain Box-A (HMGB1 Box-A). Moreover, the present invention concerns the use of said polymer conjugates of polypeptide molecules of HMGB1 Box-A to diagnose, prevent, alleviate and/or treat pathologies associated with extracellular HMGB1 and/or associated with an increased expression of RAGE.2014-03-06
20140065095NOVEL INHIBITORS - The invention relates to novel pyrrolidine derivatives of formula (I):2014-03-06
20140065096CANCER THERAPY BY EX VIVO ACTIVATED AUTOLOGOUS IMMUNE CELLS - Disclosed are therapeutic methods for ex-vivo activation of immune cells from a cancer patient for the purpose of inducing tumor regression and/or suppressing metastasis and/or tumor recurrence. In one embodiment mononuclear cells of a patient are isolated from peripheral blood and activated by a combination of innate immune system activators together with means allowing for T cell activation.2014-03-06
20140065097Immunotherapy - The present invention provides combinations of (a) an immunoconjugate comprising at least one antigen-binding moiety and an effector moiety, and (b) an antibody engineered to have increased effector function, for use in treating a disease in an individual in need thereof. Further provided are pharmaceutical compositions comprising the combinations, and methods of using them.2014-03-06
20140065098METHOD TO AUGMENT IMMUNE SYSTEM IN RESPONSE TO DISEASE OR INJURY - In one example, the present invention comprises a deliberate insult or the recognition that an insult has occurred in a patient, which insult induces an immune recognition event. The T cell repertoire is catalogued from samples of the patient's lymphocytes from before and after the insult in order to detect and sequence the TCR alpha and beta loci of highly expanded T cell clonotypes. In some examples, this information is used in turn to generate autologous T cells or to create autologous genetically-engineered T cells, either of which include TCR sequences that target the individual's disease or injury, resulting in cure or amelioration of symptoms.2014-03-06
20140065099Methods of Treating Mitochondrial Dysfunction - The present invention provides methods of treating various disorders associated with mitochondrial dysfunction, including but not limited to metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, and diseases of aging.2014-03-06
20140065100Compositions and Methods for Cancer Immunotherapy - The invention relates to immunotherapeutic compounds and to methods for stimulating an immune response in a subject individual at risk for developing cancer, diagnosed with a cancer, in treatment for cancer, or in post-therapy recovery from cancer or the compounds of the invention can be administered as a prophylactic to a subject individual to prevent or delay the development of cancer.2014-03-06
201400651012'-Branched Nucleosides for Treatment of Viral Infections - The present invention provides a compound of formula I:2014-03-06
20140065102METHODS FOR THE TREATMENT OF HEPATITIS B AND HEPATITIS D INFECTIONS - It is disclosed a method for the treatment of HBV infection or HBV/HDV co-infection, the method comprising administering to a subject in need of treatment a first pharmaceutically acceptable agent that removes the hepatitis B surface antigen from the blood and a second pharmaceutically acceptable agent which stimulates immune function.2014-03-06
20140065103COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRIDAE VIRAL INFECTIONS - A compound is selected from the structural formulae depicted in FIG. 2014-03-06
20140065104PROTEINS FOR USE IN HUMAN AND ANIMAL STAPHYLOCOCCUS INFECTIONS - The present invention relates to a polypeptide termed ply_pitti26 comprising the sequence as depicted in SEQ ID NO:1 as well as variants of this polypeptide. Furthermore, the present invention relates to nucleic acids and vectors encoding for said polypeptide and variants thereof as well as host cells comprising these nucleic acids and/or vectors. Finally, the present invention relates to the uses of said polypeptide, variants thereof, nucleic acid sequences, vectors and host cells, in particular for the treatment or prophylaxis of a subject infected by or exposed to Staphylococci.2014-03-06
20140065105Simian Adenovirus Nucleic Acid and Amino Acid Sequences, Vectors Containing Same, and Methods of Use - A recombinant vector comprises simian adenovirus sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.2014-03-06
20140065106Blood Plasma Based Hydrogels for Tissue Regeneration and Wound Healing Applications - The present disclosure generally relates to tissue engineering and wound healing. More particularly, the present disclosure relates to the modification of plasma with a stability conferring agent to create a hydrogel for use in regenerative medicine and other tissue engineering applications.2014-03-06
20140065107DEVICES, SYSTEMS, AND METHODS FOR MODULATING UTERINE FUNCTION - One aspect of the present disclosure relates to a method for modulating uterine function in a mammal. One step of the method includes placing a therapy delivery device into direct contact with a spinal cord target associated with uterine function. Next, the therapy delivery device is activated to deliver a therapy signal to the spinal cord target in an amount and for a time sufficient to effect a change in sympathetic and/or parasympathetic activity in the mammal and thereby modulate uterine function.2014-03-06
20140065108Tendon Stem Cells - The invention relates to tendon stem cells useful for treating a variety of diseases and condition, including tendon repair and attachment of tendon to bone. The invention is also directed to treatment and/or inhibition of bone formation by use of biglycan and/or fibromodulin.2014-03-06
20140065109USE OF SUBSTANCE P FOR MOBILIZATION OF MESENCHYMAL STEM CELLS OR PROLIFERATION OF MESENCHYMAL STEM CELLS AND FOR WOUND HEALING OR FACILITATING WOUND HEALING - The present invention relates to a use of Substance-P for the manufacture of a medicament for mobilization or proliferation of Mesenchymal stem cells (MSCs) from the bone marrow, or facilitating said mobilization or proliferation, and use of Substance-P for the manufacture of a medicament for wound-healing or facilitating wound-healing.2014-03-06
20140065110GENETICALLY MODIFIED MSC AND THERAPEUTIC METHODS - This disclosure relates to vectors, isolated cells, compositions, and methods for the treatment of critical limb ischemia and associated disorders. One aspect of the disclosure relates to a vector comprising a nucleic acid encoding a 165A isoform VEGF protein and a promoter that regulates expression of the nucleic acid encoding the VEGF.2014-03-06
20140065111Affinity Maturated T Cell Receptors And Use Thereof - The present invention relates to methods and systems for increasing the affinity of a T cell receptor (TCR) to its ligand by subjecting the TCR gene to somatic hypermutation. The present invention further relates to use of affinity maturated TCRs to create T cells reactive against a selected antigen.2014-03-06
20140065112COMPOSITIONS AND METHODS FOR MESENCHYMAL/STROMAL STEM CELL REJUVENATION AND TISSUE REPAIR BY ENHANCED CO-EXPRESSION OF TELOMERASE AND MYOCARDIN - A major risk factor for ischemic heart disease is advanced age. In adult bone marrow and other tissues, the number and function of stem cells decline with aging. Telomerase reverse transcriptase (TERT) is a nuclear protein that decreases senescence. Myocardin (MYOCD) is a transcription factor for myogenesis. Thus a method is provided for the simultaneous delivery of the telomerase reverse transcriptase (TERT) and myocardin MYOCD genes that resuscitates mesenchymal stromal cells (MSCs) from aged adipose and bone marrow tissues by increasing their capacity for survival, proliferation, and differentiation. TERT2014-03-06
20140065113GENETICALLY ENGINEERED GROWTH FACTOR VARIANTS - The present application discloses a recombinantly made protein construct that preferentially forms multimers.2014-03-06
20140065114USE OF LACTOBACILLUS FOR LIVER PROTECTION - A method for liver protection of a mammal is provided and includes administering an effective amount of isolated 2014-03-06
20140065115EFFERVESCENT COMPOSITION IN SOLID FORM FOR USE IN VAGINAL APPLICATIONS FOR THE TREATMENT OF VAGINAL INFECTIONS - The present invention relates to an effervescent composition in solid form for use in vaginal applications for the treatment of vaginal infections.2014-03-06
20140065116PROBIOTIC BACTERIA HAVING ANTIOXIDANT ACTIVITY AND USE THEREOF - The present invention relates to a composition having antioxidant activity. Furthermore, the present invention relates to probiotic bacteria having antioxidant activity and the use thereof.2014-03-06
20140065117METHODS FOR PRODUCING AND USING REJUVENATED RED BLOOD CELLS - Methods for treating blood. The methods comprise obtaining whole blood from a donor, mixing the whole blood with a red blood cell enhancement composition, and incubating the mixture of whole blood and red blood cell enhancement composition. The method can be performed at a time proximate to the time of obtaining blood from the donor, or after the blood has been stored for a period of time. The method rejuvenates red blood cells.2014-03-06
20140065118METHODS OF EXPANDING AND ASSESSING B CELLS AND USING EXPANDED B CELLS TO TREAT DISEASE - Provided herein are methods of expanding B cells, and in particularly B10 cells capable of producing IL-10, ex vivo. The methods include incubation of harvested B cells in the presence of IL-21. Compositions comprising the ex vivo expanded B cells and methods of using the expanded B cell-containing compositions to treat diseases or conditions are also provided. Methods of assessing B10 cell function in a subject are also provided.2014-03-06
20140065119METHODS AND COMPOSITIONS COMPRISING CYCLIC ANALOGUES OF HISTATIN 5 FOR TREATING WOUNDS - Compositions and methods for treating wounds are provided. The compositions include cyclic analogues of histatin (5).2014-03-06
20140065120DELIVERY OF COMPOUNDS WITH REHYDRATED BLOOD CELLS - Fixed-dried blood cells carrying an active agent are described, along with methods of making the same, methods of using the same, and compositions containing the same. The blood cells are preferably blood platelets.2014-03-06
20140065121BLOOD PLASMA BASED HYDROGELS FOR TISSUE REGENERATION AND WOUND HEALING APPLICATIONS - The present disclosure generally relates to tissue engineering and wound healing. More particularly, the present disclosure relates to the modification of plasma with a stability conferring agent to create a hydrogel for use in regenerative medicine and other tissue engineering applications.2014-03-06
20140065122Method for Removing a Microorganism Biofilm - The invention relates to a method for eliminating a biofilm of microorganism preexisting on an inert surface, characterized in that one subjects said biofilm to a cocktail of microorganisms comprising at least strains said to be “swimming” able to cross said biofilm in the plane and in the thickness, and one subjects said biofilm to at least one antimicrobial product directed against at least one microorganism of the biofilm to be eliminated.2014-03-06
20140065123PEGYLATED ANALOGUE PROTEIN OR CANINE URATE OXIDASE, PREPARATION METHOD AND USE THEREOF - Provided are a PEGylated analogue protein of canine urate oxidase, preparation method and use thereof. The analogue protein of canine urate oxidase is a canine urate oxidase, or a chimeric protein comprising part of the amino acid sequence of a canine urate oxidase and part of the amino acid sequence of a human urate oxidase, or a mutant protein thereof. The PEGylated analogue protein of canine urate oxidase and pharmaceutical compositions thereof according to the present invention can be used for the prevention and/or treatment of hyperuricemia and chronic gout.2014-03-06
20140065124PIGGYBAC TRANSPOSON VARIANTS AND METHODS OF USE - The present invention provides hyperactive piggyBac transposons, in particular hyperactive piggyBac transposons from 2014-03-06
20140065125PHARMACEUTICAL COMPOSITOIN FOR TREATING DEPRESSION AND METHOD FOR PREPARATION THEREOF - A pharmaceutical composition for treating depression and method for preparation thereof is provided. The pharmaceutical composition includes Radix 2014-03-06
20140065126BChE ALBUMIN FUSIONS FOR THE TREATMENT OF COCAINE ABUSE - A method of attenuating a biological effect of cocaine exposure in a primate. Such method includes administering to the primate an amount of a BChE-albumin fusion protein comprising the amino acid substitutions A227S, S315G, A356W, and Y360G, wherein the amount of the fusion protein is effective to cause attenuation of the biological effect of cocaine exposure in the primate.2014-03-06
20140065127Staphylococcus haemolyticus Prophage PhiSH2 Endolysin is Lytic for Staphylococcus aureus - Methicillin-resistant (MRSA) and multi-drug resistant strains of 2014-03-06
20140065128TREATMENT FOR IgE-MEDIATED DISEASE - The invention provides an EndoS polypeptide, or a polynucleotide encoding an EndoS polypeptide, for use in a method for treating or preventing a disease or condition mediated by IgE antibodies.2014-03-06
20140065129METHODS AND DEVICES FOR TREATING PARASYMPATHETIC BIAS MEDIATED CONDITIONS - Methods for treating a subject for a parasympathetic bias mediated condition are provided. Aspects of the methods include modulating at least a portion of the subject's autonomic nervous system to increase the sympathetic/parasympathetic activity ratio in a manner effective to treat the subject for the parasympathetic bias mediated condition. In some instances, the subject is known to have parasympathetic bias. Also provided are devices that find use in practicing various embodiments of the methods.2014-03-06
20140065130METHOD FOR TREATING PREMATURE EJACULATION WITH A NEUROTOXIN - Methods for treating premature ejaculation and prolongation of climax time in a patient in need thereof by local administration of a Clostridial neurotoxin, such as a botulinum toxin, are provided.2014-03-06
20140065131EXTRACT OF A MYCELIATED AGRICULTURAL SUBSTRATE AND ITS USE AS A NUTRACEUTICAL COMPOSITION - The present invention provides an aqueous extract of a myceliated agricultural substrate for use as a nutraceutical or food composition for human consumption comprising at least one small molecule compound, wherein mycelia is grown on an agricultural substrate by inoculating the agricultural substrate with a pure strain of a fungal culture selected from the group comprising Basidiomycota and Ascomycota derived from a liquid fermentation, under optimum growth conditions. The present invention further provides methods of formation of an aqueous extract and nutraceutical or food compositions obtained from the extract. The aqueous extract and the nutraceutical compositions obtained from the extract thereof have neuroprotective and neuroregenerative properties amongst many other therapeutic properties.2014-03-06
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