| 09th week of 2010 patent applcation highlights part 28 |
| Patent application number | Title | Published |
|---|
| 20100055668 | Fluid-Transfer Collection Assembly Including Breakable Vial and Method of Using Same - A method of using a fluid transfer and mixing collection assembly includes depressing a flexible member to cause a force to be imparted to a breakable vial to break the vial, releasing the second fluid therein into an interior of the flexible member; releasing the flexible member to impart a negative pressure in the interior of the flexible member to draw a first fluid into the interior of the flexible member through the inlet check valve to mix with the second fluid; and depressing the flexible member to impart a positive pressure in the interior of the flexible member to pump the mixed first fluid and second fluid out of the interior of the flexible member through an outlet check valve and be transferred to test media. | 2010-03-04 |
| 20100055669 | Generation of Recombinant Genes in Bacteriophages - In vivo methods for generating and detecting recombinant DNA sequences in bacteriophages or plasmids containing bacteriophage sequences, methods for generating hybrid genes and hybrid proteins encoded by these hybrid genes by the use of bacteriophages and plasmids containing bacteriophage sequences, bacteriophages and plasmids that can be used in these methods, and kits comprising appropriate bacterial host cells and bacteriophages or plasmids are described. | 2010-03-04 |
| 20100055670 | GROWTH OF WILD-TYPE HEPATITIS A VIRUS IN CELL CULTURE - The invention provides recombinant Hepatitis A Virus (HAV) nucleic acids and host cells that are permissive for their growth and replication. The recombinant Hepatitis A Virus nucleic acids not particularly limited, except that they incorporate at least one heterologous nucleic acid fragment. The heterologous nucleic acid can encode a selectable marker gene and such recombinant HAV nucleic acids are useful for selecting cells that are permissive for growth and replication of wild type HAV. Alternatively, the heterologous nucleic acid may encode a vaccine antigen or other expression product that is desirable to express in a cell harboring the recombinant HAV nucleic acid. The invention further provides cell lines permissive for growth and replication of wild type HAV or HAV having minimal mutations for growth in cell culture. The invention further provides methods for producing HAV vaccines and for monitoring environmental and patient samples for the presence of HAV. | 2010-03-04 |
| 20100055671 | Method for Determining Transduction Efficiency and Virus Dosage of Baculovirus - A method for determining transduction efficiency of baculovirus includes: providing a recombinant baculovirus, in which the recombinant baculovirus includes an inducible promoter and a reporter gene positioned downstream the inducible promoter; adding the recombinant baculovirus to incubating environment of a mammalian cell for transduction; adding an inducer to promote expression of the reporter gene in the mammalian cell; and analyzing the percentage of the mammalian cell expressing the reporter gene to determine the transduction efficiency of the recombinant baculovirus. The method provides the ability to quantitatively analyze baculovirus transduction and is a simple and faster quantitative method applicable in transduction and other research study by including an inducible promoter and a reporter gene and thus prevents from imposing excessive metabolic burden to the cells. A method for determining virus dosage of baculovirus applied in genetic therapy is also disclosed. | 2010-03-04 |
| 20100055672 | 100% SEQUENCE IDENTITY DETECTION METHODS FOR VARIABLE GENOMES - The present disclosure provides methods, reagents and kits for the detection of all known human variants of influenza A virus and at least 90% of avian and swine variants of influenza A virus in a biological sample, based on amplification primers and detection probes that are specific to a highly conserved region of the influenza A matrix gene. | 2010-03-04 |
| 20100055673 | TRANSPARENT MICROFLUIDIC DEVICE - A device for analysing the status of a biological entity. The device ( | 2010-03-04 |
| 20100055674 | UTILIZING LIVER CELL LINE QSG-7701 TO BE INFECTED WITH HEPATITIS B VIRUS - The use of the liver cell line QSG-7701 for HBV infection includes the following steps: directly infecting QSG-7701 cells with purified HBV particles and facilitating the infection by DMSO and/or PEG treatment. The easily available QSG-7701 liver cell line may not require pre-differentiation induction and is naturally susceptible for HBV infection. This cell line provides near normal physiological conditions for HBV infection, especially the infection conditions that are characterized with Chinese origin. This cell line is suitable for investigating the life cycle of HBV. Therefore, this cell line is useful for the investigation of viral infection processes and for the development of drugs that specifically target these processes. | 2010-03-04 |
| 20100055675 | METHOD FOR DETECTING MEASLES VIRUS, MEMBRANE ASSAY TEST DEVICE, AND MEMBRANE ASSAY TEST KIT - Method for detecting a measles virus in an analyte, comprising forming a complex of a first monoclonal antibody being capable of binding to a first epitope of a measles virus nuclear protein and being immobilized on a solid phase, a second monoclonal antibody being capable of binding to a second epitope of a measles virus nuclear protein different from the first epitope and being labeled, and a measles virus nuclear protein contained in the analyte, on the solid phase; and detecting the measles virus based on the amount of the label of the complex formed on the solid phase, is disclosed. Membrane assay test device, and membrane assay test kit are also disclosed. | 2010-03-04 |
| 20100055676 | METHOD OF ASSAYING ALPHA 1, 4-N-ACETYLGLUCOSAMINE TRANSFERASE (ALPHA 4GNT) MRNA - A method for assaying α1,4-N-acetylgiucosamine transferase (α4GnT) mRNA present in a sample, the method comprising a step of using a first primer homologous to at least a portion downstream from the 5′-end of a specified nucleotide sequence of the RNA and a second primer complementary to at least a portion upstream from the 3′-end of the specified nucleotide sequence to produce double-stranded DNA containing the promoter sequence and the specified nucleotide sequence downstream from the promoter sequence, wherein at least one of the first and second primers has a promoter sequence at the 5′-end, a step of using the double-stranded DNA as template to produce an RNA transcript, a step of using the RNA transcript in turn as template for DNA synthesis to produce the double-stranded DNA, a step of nucleic acid amplification in which the aforementioned steps are repeated under conditions that simultaneously promote each of the steps, and a step of assaying the amount of the RNA transcript. | 2010-03-04 |
| 20100055677 | Method for genetic identification of unknown organisms - A method of rapid, genome and proteome based identification of unknown pathogenic or non-pathogenic organisms in a complex sample. The entire sample is analyzed by creating millions of emulsion encapsulated microdroplets, each containing a single pathogenic or non-pathogenic organism sized particle and appropriate reagents for amplification. Following amplification, the amplified product is analyzed. | 2010-03-04 |
| 20100055688 | SLIT2 CANCER MARKERS - This invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, this invention relates to SLIT2 cancer markers that are useful as diagnostic markers and clinical targets for prostate cancer. | 2010-03-04 |
| 20100055689 | MULTIFACTORIAL METHODS FOR DETECTING LUNG DISORDERS - Described herein are multifactorial methods for detecting, diagnosing or aiding in the diagnosis of lung disorders or disease, e.g., lung cancer. The methods disclosed utilize multiple diagnostic paradigms, for example, to improve diagnostic sensitivity, specificity, negative predictive value and/or positive predictive value over each of the paradigms alone. For example, a clinicogenomic model is disclosed for lung cancer diagnosis which combines clinical factors and gene expression, particularly a sensitive and specific gene expression biomarker. | 2010-03-04 |
| 20100055690 | PROGNOSTIC BIOMARKERS IN PATIENTS WITH OVARIAN CANCER - The present invention provides methods for assessing an ovarian cancer patient's survival status. Also, methods for evaluating the ovarian cancer state of a patient are described herein. These methods involve the detection, analysis, and classification of biological patterns in biological samples. The biological patterns are obtained using, for example, mass spectrometry systems and other techniques. | 2010-03-04 |
| 20100055691 | SCREENING METHOD FOR THERAPEUTIC AGENT FOR AMYOTROPHIC LATERAL SCLEROSIS - The objective of the present invention is to provide methods of screening therapeutic agents for juvenile familial amyotrophic lateral sclerosis (ALS2). The invention provides a method of screening therapeutic agents for juvenile familial amyotrophic lateral sclerosis, comprising a step of assessing a substance that suppresses the expression of Tollip in cells as a therapeutic agent for juvenile familial amyotrophic lateral sclerosis; a method of screening therapeutic agents for juvenile familial amyotrophic lateral sclerosis, comprising a step of assessing a substance that promotes migration of Tollip in cells from the cytoplasm to the cell nucleus as a therapeutic agent for juvenile familial amyotrophic lateral sclerosis; and a method of screening therapeutic agents for juvenile familial amyotrophic lateral sclerosis, comprising a step of assessing a substance that inhibits the interaction between Tollip and IRAK-1 in cells as a therapeutic agent for juvenile familial amyotrophic lateral sclerosis. | 2010-03-04 |
| 20100055692 | METHOD FOR SELECTION OF HOP STRAIN, BLEEDING MARKER FOR USE IN SELECTION OF HOP STRAIN, AND PRIMER SET - It is an object of the invention to screen for hop varieties with high α acid contents, as well as hop varieties with high contents of α acids, β acids, myrcene and/or xanthohumol in addition to α acids, within a short time period utilizing a molecular screening method that employs a breeding marker. The invention provides a breeding marker represented by the following (a) or (b), which is used for screening of hop varieties with high α acid contents. | 2010-03-04 |
| 20100055693 | LUCIFERASE SIGNAL ENHANCING COMPOSITIONS - Reagents and compositions for use in reactions catalysed by luciferase enzymes, and in particular for use in luciferase-based gene reporter assays are described. The invention also provides methods and compositions for, inter alia, increasing the sensitivity and/or improving the kinetics of luciferase-catalysed reactions. | 2010-03-04 |
| 20100055694 | Molecular signature representative of dysfunctions in epidermal homeostasis - The present invention concerns a method for evaluating the epidermal homeostasis of the skin of a subject, comprising differential analysis of the expression of a gene, preferably of two genes, selected from the group of genes consisting of KRT6B, KRT16, ESRRA, CBX3, MAP3K5, TRIO, PIK3CD, TCRB, PRRG2, ICP22BP, GPX3, GBA, BPGM, NID1, SMT3H2, LGALS2, DOC1, PRKCG, S100A8, S100A9, S100A2, S100A7, K15, SPRR1B and GSN in response to a physical or chemical challenge of the stratum corneum. It also concerns various methods for diagnosing the state of the epidermis of an individual and methods for detecting and screening products or procedures which can improve epidermal homeostasis. The invention also pertains to kits and arrays which can be used in these various methods and processes. | 2010-03-04 |
| 20100055695 | Method For Generating Aptamers with Improved Off-Rates - The present disclosure describes methods for producing aptamers and photoaptamers having slower dissociation rate constants than are obtained using prior SELEX and photoSELEX methods. The disclosure further describes aptamers and photoaptamers having slower dissociation rate constants than those obtained using prior methods. This invention relates to the field of diagnostic histology, cytology, histopathology, and cytopathology methods and reagents for the detection of various disease states. More specifically, the invention relates to the use of aptamers in histologic, cytologic, histopathic, and/or cytopathic diagnostic methods. Aptamers may be provided that react with specific target molecules contained within a histological or cytological sample. Aptamers may be used to assess localization, relative density, and presence or absence of one or more target. Targets may be selected that are specific and diagnostic of a given disease state for which the sample was collected. Aptamers may be used to introduce target specific signal moieties. Antigen retrieval methods may be applied to the sample prior to reaction with the specific aptamer/s to improve interaction of the aptamer and target within the sample. Or aptamers may be developed for the specific target that eliminates the need for the antigen retrieval process. In addition to target identification, aptamers may be used to amplify signal generation through a variety of methods. | 2010-03-04 |
| 20100055696 | DRG11-Responsive (DRAGON) Gene Family - This invention features methods and compositions useful for treating and diagnosing diseases of the nervous system, retina, skin, muscle, joint, and cartilage using a Dragon family protein. Protein and nucleic acid sequences of human, murine, zebrafish, and | 2010-03-04 |
| 20100055697 | POSITIVE SELECTION OF SERUM PROTEINS FOR PROTEOMIC ANALYSIS - This invention relates to methods and kits for positive selection of species of interest based on peptide/protein sequence from a biological sample. The species of interest may be proteins and/or peptides of interest which may be placed through a mass spectrometer to obtain a blood peptide/protein signature. The blood peptide/protein signature may be used in proteomic analysis. The techniques include but are not limited to the use of collectors comprising nucleic acid molecules to extract a composition that has a lower concentration of a high abundance species of interest from a sample. This limits the level of influence that any collectors species may have on the results of a mass spectra. | 2010-03-04 |
| 20100055708 | Assay for Chlamydia trachomatis by amplification and detection of Chlamydia trachomatis cytotoxin gene - A region of the | 2010-03-04 |
| 20100055709 | Tubulin Mutation Diagnostic - The present invention relates to methods for determining the potential of a subject to respond to a particular therapeutic agent, by determining the presence of one or more nucleotide or amino acid variants in the β-tubulin gene or protein. Also provided are methods for treating subjects whose potential to respond to a therapeutic agent has been evaluated. For use in the methods of the invention, there are provided variants of the β-tubulin gene. variants of the β-tubulin protein, nucleic acid molecules and agents which bind to the variant β-tubulin nucleic acid molecules and variant β-tubulin protein, respectively, and kits comprising the same. | 2010-03-04 |
| 20100055710 | Novel Carbohydrate Profile Compositions From Human Cells and Methods for Analysis and Modification Thereof - The invention describes methods for production of novel composition of glycans, glycomes, from human multipotent stem cells. The invention is further directed to methods for modifying the glycomes and analysis of the glycomes and the modified glycomes. Furthermore the invention is directed to stem cells carrying the modified glycomes on their surfaces. | 2010-03-04 |
| 20100055711 | METHODS FOR THE IDENTIFICATION OF PI3K INTERACTING MOLECULES AND FOR THE PURIFICATION OF PI3K - The present invention relates to a method for the identification of a PI3K interacting compound, comprising the steps of a) providing a protein preparation containing PI3K, b) contacting the protein preparation with phenylthiazole ligand 1 immobilized on a solid support under conditions allowing the formation of a phenylthiazole ligand 1-PI3K complex, c) incubating the phenylthiazole ligand 1-PI3K complex with a given compound, and d) determining whether the compound is able to separate PI3K from the immobilized phenylthiazole ligand 1. Furthermore, the present invention relates to a method for the identification of a PI3K interacting compound, comprising the steps of a) providing a protein preparation containing PI3K, b) contacting the protein preparation with phenylthiazole ligand 1 immobilized on a solid support and with a given compound under conditions allowing the formation of a phenylthiazole ligand 1-PI3K complex, and c) detecting the phenylthiazole ligand 1-PI3K complex formed in step b). Furthermore, the present invention relates to a method for the identification of a PI3K interacting compound, comprising the steps of a) providing two aliquots of a protein preparation containing PI3K, b) contacting one aliquot with the phenylthiazole ligand 1 immobilized on a solid support under conditions allowing the formation of a phenylthiazole ligand 1-PI3K complex, c) contacting the other aliquot with the phenylthiazole ligand 1 immobilized on a solid support and with a given compound under conditions allowing the formation of a phenylthiazole ligand 1-PI3K complex, and d) determining the amount of the phenylthiazole ligand 1-PI3K complex formed in steps b) and c). Furthermore, the present invention relates to a method for the identification of a PI3K interacting compound, comprising the steps of a) providing two aliquots comprising each at least one cell containing PI3K, b) incubating one aliquot with a given compound, c) harvesting the cells of each aliquot, d) lysing the cells in order to obtain protein preparations, e) contacting the protein preparations with the phenylthiazole ligand 1 immobilized on a solid support under conditions allowing the formation of a phenylthiazole ligand 1-PI3K complex, and f) determining the amount of the phenylthiazole ligand 1-PI3K complex formed in each aliquot in step e). | 2010-03-04 |
| 20100055712 | Oligopeptides for treatment of osteoporosis and other bone diseases and methods therefor - Methods of identifying compounds for treating Alzheimer's disease are disclosed. These methods comprise a) forming an in vitro mixture comprising i) cells expressing LDL receptor related protein 1 (LRP1), ii) an LRP1 ligand comprising a label, and iii) a candidate compound; and b) determining quantity of the label incorporated by the cells, whereby a candidate compound is deemed effective for treating Alzheimer's disease if the quantity of label incorporated by the cells exceeds that of a control in vitro mixture comprising cells expressing LRP1 and the LRP1 ligand, but not comprising the compound. | 2010-03-04 |
| 20100055713 | CHEMILUMINESCENCE SENSOR ARRAY - Embodiments of the invention relate to integrated chemiluminescence devices and methods for monitoring molecular binding utilizing these devices and methods. These devices and methods can be used, for example, to identify antigen binding to antibodies. The devices include both a chemiluminescence material and a detector integrated together. | 2010-03-04 |
| 20100055714 | IKB kinase, subunits thereof, and methods of using same - The present invention provides an isolated nucleic acid molecules encoding IκB kinase (IKK) catalytic subunit polypeptides, which are associated with an IKK serine protein kinase that phosphorylates a protein (IκB) that inhibits the activity of the NF-κB transcription factor, vectors comprising such nucleic acid molecules and host cells containing such vectors. In addition, the invention provides nucleotide sequences that can bind to a nucleic acid molecule of the invention, such nucleotide sequences being useful as probes or as antisense molecules. The invention also provides isolated IKK catalytic subunits, which can phosphorylate an IκB protein, and peptide portions of such IKK subunit. In addition, the invention provides anti-IKK antibodies, which specifically bind to an IKK complex or an IKK catalytic subunit, and IKK-binding fragments of such antibodies. The invention further provides methods of substantially purifying an IKK complex, methods of identifying an agent that can alter the association of an IKK complex or an IKK catalytic subunit with a second protein, and methods of identifying proteins that can interact with an IKK complex or an IKK catalytic subunit. | 2010-03-04 |
| 20100055715 | Nucleic and amino acid sequences of prokaryotic ubiquitin-like protein and methods of use thereof - The present invention relates to prokaryotic ubiquitin-like protein (Pup) nucleic acid sequences and Pup amino acid sequences encoded therefrom. Also encompassed are antibodies that are immunologically specific for Pup. Methods directed to isolation and identification of pupylated substrates that utilize the conjugated Pup as an affinity tag are also included. Pupylated substrates that are identified using the method and reagents of the present invention provide tools useful for the identification of additional components of prokaryotic proteasomal machinery. Modulators of Pup activity and methods for identifying such modulators are also encompassed herein. | 2010-03-04 |
| 20100055716 | DETECTION INSTRUMENT, ANALYSIS DEVICE, AND DETECTION METHOD - A detection instrument of the present invention includes: a flow path through which a sample to be examined flows, the flow path having a plurality of detection areas in each of which a target substance in the sample is detected, the plurality of detection areas respectively including detection sections and immobilizing sections each of which immobilizes an antibody, and the plurality of detection areas being separated by bulbs. As such, it is possible to provide a detection instrument which can detect plural kinds of target substances in a single flow path. | 2010-03-04 |
| 20100055717 | SAMPLING AND ASSAY DEVICE TOGETHER WITH METHODS FOR USE THEREOF - An immunochemical sampling device, kits including the sampling device, processes for production of the sampling device, and methods for use of the sampling device in lateral flow immunoassays. The sampling device comprises a solid support that is partially wrapped in a porous carrier, then covered in a hydrophobic cover. At its distal end, the porous carrier comprises a labeled binding reagent that is retained in the solid support until released into controlled flow with the liquid sample when the sampling device is brought into contact with a test strip. | 2010-03-04 |
| 20100055718 | NANOPLATE DYE PLATFORM AND METHODS OF MAKING AND USING THE SAME - Embodiments disclosed herein relate to labeling reagents comprising a plurality of nanoplates attached to dye molecules. The nanoplates may be configured into stacks and/or at least partially surrounded by a surrounding layer. The reagent may then be used to label a target (e.g., structure or environment). | 2010-03-04 |
| 20100055719 | Screening method for identifying new aminoacyl-tRNA synthetase inhibitors - The method comprising: a) obtaining a gene sequence codifying a naturally occurring aminoacyl-tRNA synthetase; b) engineering the gene codifying for said aminoacyl-tRNA synthetase, resulting into an aminoacyl-tRNA synthetase with a defective activity, with the proviso that the engineering does not affect the functionality of the catalytic site of the enzyme; c) cloning the gene resulting from step (b) in an expression vector; d) transforming isolated mammalian cells with the expression vector resulting from step (c); e) growing the recombinant cells resulting from step (d) in a nutrient medium under conditions which allow the expression of the engineered aminoacyl-tRNA synthetase, resulting the expression into cell death or a decrease in the rate of cell division; f) providing a substance to be tested to the medium resulting from step (e); and g) analyzing the resulting cell growth, wherein if there is an increase in cell growth, then the substance selectively inhibits the activity of the engineered aminoacyl-tRNA synthetase and does not affect to its cellular ortholog, resulting in that said substance is a candidate to drug. | 2010-03-04 |
| 20100055720 | USE OF THE 4-lBB RECEPTOR FOR IDENTIFYING AND/OR SEPARATING ACTIVATED REGULATORY TH CELLS (TREG) - The invention relates to the use of the 4-1BB receptor for identifying and/or separating specific regulatory Th cells after activation with an antigen, polyclonal regulatory Th cells after polyclonal activation and to a method for the identification and/or separation of regulatory Th cells, the regulatory T cells being detected on the basis of the expression of the 4-1BB receptor by an antibody, an antigen or ligands which are coupled to a fluorescent substance, haptenes or magnetic microparticles. The invention also relates to a kit comprising an antibody, an antigen or ligands for detecting the 4-1BB receptor for the identification and/or separation of a regulatory Th cell, the antibody being coupled to a fluorescent substance, haptenes or magnetic microparticles. | 2010-03-04 |
| 20100055721 | Surface Enhanced Raman Scattering and Multiplexed Diagnostic Assays - Multiplexed lateral flow assays, related methods, and devices are disclosed which are capable of simultaneously detecting multiple analytes. The assays are preferably immunoassays and can be multiplexed spatially, spectrally, and both spatially and spectrally. Multiplexed assays are disclosed employing quantum dots for applications including the detection of human proteins and the monitoring of microorganisms relevant to water contamination. The multiplexed assays can employ one or more species of Surface Enhanced Raman Scattering nanoparticles, with one or more species having a unique Raman shift spectrum. The invention is widely adaptable to a variety of analytes such as biowarfare agents, human clinical markers, and other substances. | 2010-03-04 |
| 20100055722 | Methods of Detecting A Neurological Condition Via Analysis of Circulating Phagocytes - The present invention features methods of monitoring or detecting a neurological or inflammatory condition in a patient. The method comprises (1) obtaining from the patient a fluid sample from outside of a brain tissue of the patient, wherein the fluid sample contains a circulating phagocyte, and (2) detecting for one or more biomarkers (e.g., a panel of biomarkers) inside the phagocyte, wherein the biomarker is associated with the respective neurological or inflammatory condition. | 2010-03-04 |
| 20100055723 | Galectin-3-Binding Protein as a Biomarker of Cardiovascular Disease - The present invention provides compositions and methods for using biomarkers to diagnose and monitor cardiovascular associated diseases and disorders. More specifically, the present invention provides Galectin-3-binding protein as a biomarker for disease. | 2010-03-04 |
| 20100055724 | METHODS OF DETECTING AUTOANTIBODIES FOR DIAGNOSING AND CHARACTERIZING DISORDERS - Methods for detecting and/or quantitating levels of autoantibodies in subjects are provided. Methods for diagnosing and/or characterizing a disorder associated with autoantibody production are further provided. In some embodiments, the disorder diagnosed and/or characterized can be a cancer or an infertility disorder. | 2010-03-04 |
| 20100055725 | SYSTEM FOR ASSAYS OF AMINOTRANSFERASE - An assay system ( | 2010-03-04 |
| 20100055726 | ASPARAGINASES - The invention relates to new asparaginases having improved properties, preferably improved thermotolerance, such as improved activity at high temperatures and/or improved thermostability. The invention also relates to DNA sequences encoding such improved asparaginases, their production in a recombinant host cell, as well as methods of using the asparaginases, in particular for reduction of acrylamide in foods. The invention furthermore relates to methods of generating and preparing asparaginase variants having improved properties. | 2010-03-04 |
| 20100055727 | FRET PROTEASE ASSAYS FOR BOTULINUM SEROTYPE A/E TOXINS - The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus toxins. A clostridial toxin substrate of the invention contains a donor fluorophore; an acceptor having an absorbance spectrum overlapping the emission spectrum of the donor fluorophore; and a clostridial toxin recognition sequence that includes a cleavage site, where the cleavage site intervenes between the donor fluorophore and the acceptor and where, under the appropriate conditions, resonance energy transfer is exhibited between the donor fluorophore and the acceptor. | 2010-03-04 |
| 20100055748 | L-AMINO ACID PRODUCING BACTERIUM AND METHOD FOR PRODUCING L-AMINO ACID - An L-amino acid can be produced by culturing an L-amino acid-producing bacterium which belongs to the Enterobacteriaceae family and which has been modified so that the expression of a yggG gene is enhanced. | 2010-03-04 |
| 20100055749 | PROCESS FOR THE PRODUCTION OF CLAVULANIC ACID - The present invention relates to a process for preparation of a pharmaceutically acceptable metal salt of clavulanic acid comprising the steps of (a) fermenting of a microorganism capable of producing and excreting the clavulanic acid into the broth; (b) removing biomass and other solid material from the clavulanic acid containing fermentation broth obtained in step (a); (c) acidifying the solution obtained after step (b) to a pH between 1 and 3 and extracting the acidified solution with a partly or fully water-immiscible solvent and separating the clavulanic acid containing extract; (d) mixing the clavulanic acid containing extract obtained in step (c) with a metal donor and at least one additional cosolvent to result in an insoluble, preferably crystalline metal clavulanate salt with a yield of at least 80%; and (e) separating the insoluble, preferably crystalline, metal clavulanate salt from the mixture obtained in step (d). | 2010-03-04 |
| 20100055750 | POLYESTER SYNTHESIS - The present disclosure provides for enzymatic polymerization to produce polyester resins suitable for use in manufacturing toners. In embodiments, crystalline copolymers, which are polyesters, may be synthesized from lactones, cyclic anhydrides, cyclic carbonates, and combinations thereof. These crystalline copolymers, in turn, may be utilized in the synthesis of toner particles. | 2010-03-04 |
| 20100055751 | KETOREDUCTASE POLYPEPTIDES AND USES THEREOF - The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme including the capability of stereo specifically reducing (R)-2-methylpentanal to (R)-2-methylpentanol. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to produce (R)-2-methylpentanol and related compounds. | 2010-03-04 |
| 20100055752 | Native Grain Amylases in Enzyme Combinations for Granular Starch Hydrolysis - Described herein are starch hydrolysis processes for obtaining fermentable sugars from starch in milled plant material at temperatures below the starch gelatinization temperature and using exogenous plant alpha amylases further to the fermentation of the sugars to produce end products, such as ethanol. | 2010-03-04 |
| 20100055753 | METHOD FOR THE PRODUCTION OF CONCENTRATED ALCOHOL FROM FERMENTATION BROTHS - A method for obtaining a concentrated alcohol solution from a lignocellulosic feedstock. The lignocellulosic feedstock is hydrolyzed to prepare a sugar solution. The sugar solution is fermented to produce a fermentation broth comprising alcohol and at least about 1 g ammonium ions/kg fermentation broth. The alcohol in the fermentation broth is then concentrated by distillation to produce an alcohol-enriched vapour. Either before distillation, during distillation or during the azeotrope breaking process, the concentration of ammonia in the alcohol-enriched vapour can be reduced by acid addition to at most about 300 ppm. The alcohol in the alcohol-rich vapour is then further concentrated by an azeotrope breaking process to provide the concentrated alcohol solution. | 2010-03-04 |
| 20100055754 | METHODS FOR INCREASING ISOPRENOID AND ISOPRENOID PRECURSOR PRODUCTION BY MODULATING FATTY ACID LEVELS - The present invention provides methods of increasing production of an isoprenoid or an isoprenoid precursor in a host cell, the methods generally involving modulating the level of activity of a fatty acid biosynthetic pathway enzyme in the host cell and/or culturing the host cell in a culture medium comprising a fatty acid or a compound that can be metabolized in a cell or broken down in the medium to yield a fatty acid and/or culturing the host cell in a culture medium having increased osmolarity. | 2010-03-04 |
| 20100055755 | Methods of Eliminating or Reducing Expression of Genes in Filamentous Fungal Strains by Transitive RNA Interference - The present invention relates to methods of reducing or eliminating expression of a target gene in a filamentous fungal strain by transitive RNA interference. | 2010-03-04 |
| 20100055756 | System and method for modifying biological cells using an ultra-short pulsed laser - A system and method for modifying a biological cell are presented. A beam of ultra-short pulses is generated. The beam is delivered to a mixture that includes a biological cell and a medium. The beam is focused to form a focal zone. The focal zone may be proximate to the biological cell. An event is generated at the focal zone that effectuates a modification to the biological cell. | 2010-03-04 |
| 20100055757 | STEM CELLS AND METHODS INCORPORATING ENVIRONMENTAL FACTORS AS A MEANS FOR ENHANCING STEM CELL PROLIFERATION AND PLASTICITY - Disclosed are methods for expanding stem cells that use a unique combination of environmental factors and cell culture conditions to produce stem cells having enhanced proliferation and differentiation characteristics. Also disclosed are methods for enhancing the engraftment and/or migratory potential of stem cells for therapeutic uses. Stem cells having unique proliferation, differentiation, migratory and engraftment characteristics are also disclosed. | 2010-03-04 |
| 20100055758 | Magnetic Device for Isolation of Cells and Biomolecules in a Microfluidic Environment - The present invention features a new and useful magnetic device and methods of its use for isolation, enrichment, and purification of cells, proteins, DNA, and other molecules. In general the device includes magnetic regions or obstacles to which magnetic particles can bind. The chemical groups, i.e., capture moieties, on the surface of the magnetic particles may then be used to bind particles, e.g., cells, or molecules of interest from complex samples, and the bound species may then be selectively released for downstream collection or further analysis. | 2010-03-04 |
| 20100055759 | TRANSPARENT POLYMER MEMBRANE FOR LASER DISSECTION - The disclosure encompasses transparent polymer membranes suitable for use in laser microdissection methods, where the membranes allow the subsequent analysis of the microdissected cell or cells with light of a wavelength that can traverse the membrane with little if any absorbance by the membrane. The transfer capture membranes of the disclosure comprise a polymeric composition having the characteristic of being cut by a laser light at a wavelength less than 360 nm, while being substantially optically transparent at a wavelength greater than about 360 nm. The disclosure further provides methods of isolating a cell or population of cells from a tissue, comprising: overlaying a tissue sample with a transfer capture membrane having the characteristic of being cut by a laser light at a wavelength less than 360 nm, and substantially optically transparent at a wavelength greater than about 360 nm, defining an area of the transfer capture membrane by a laser light cutting through the thickness of the transfer capture membrane and the issue sample; and removing the defined area of the transfer capture membrane with the targeted cell or population of cells adhering thereto. | 2010-03-04 |
| 20100055760 | ENZYME PREPARATIONS - The invention is directed to enzyme preparations which are obtainable by providing enzyme immobilizates which comprise enzymes or microorganisms comprising enzymes immobilized on an inert support with a polyethersilicone coating obtained by hydrosilylation, to a process for preparing such enzyme preparations and to the use of enzyme preparations as an industrial biocatalyst. | 2010-03-04 |
| 20100055761 | METHODS, COMPOSITIONS, AND KITS FOR THE SELECTIVE ACTIVATION OF PROTOXINS THROUGH COMBINATORAL TARGETING - The present invention provides methods and compositions for treating various diseases through selective killipg of targeted cells using a combinatorial targeting approach. The invention features protoxin fusion proteins containing a cell targeting moiety and, a modifiable activation moiety which is activated by an activation moiety not naturally operably found in, on, or in the vicinity of a target cell. These methods also include the combinatorial use of two or more therapeutic agents, at minimum comprising a protoxin and a protoxin activator, to target and destroy a specific cell population. | 2010-03-04 |
| 20100055762 | Method for Preparation of Hepatocyte Using Es Cell - This invention relates to an agent for promoting differentiation of an ES cell, preferably an agent for promoting differentiation of an ES cell into a hepatocyte or a prophylactic agent for teratoma, comprising uPA. | 2010-03-04 |
| 20100055763 | METHOD FOR THE PRODUCTION AND PURIFICATION OF RETROVIRAL VECTORS - The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of low-medium perfusion rates in an attached cell culture system provides for improved yields. In other embodiments, the inventors have shown that there is improved Ad-p53 production with cells grown in serum-free conditions, and in particular in serum-free suspension culture. Also important to the increase of yields is the use of detergent lysis. Combination of these aspects of the invention permits purification of virus by a single chromatography step that results in purified virus of the same quality as preparations from double CsCl banding using an ultracentrifuge. | 2010-03-04 |
| 20100055764 | CELL CULTURE APPARATUS AND METHOD - Cell culture apparatuses and methods for culturing cells include bags for culturing cells. The bags are folded and unfolded to control cell culture conditions. As the bags are folded, segmented sealed chambers for culturing cells are formed. As the bags are unfolded, the segments are unsealed allowing for exchange of fluid between the regions of the subchambers. | 2010-03-04 |
| 20100055765 | SEMI-CLOSED LOOP ALGA-DIESEL FUEL PHOTOBIOREACTOR USING WASTE WATER - A semi-closed loop diesel photobioreactor system and method are provided for producing diesel fuel from wild algae or from specialized algae that has been biologically modified for high efficiency oil production using waste water as a primary food source. The diesel photobioreactor provides a semi-closed loop system with an opening to acquire waste water below the surface to obtain waste water nutrients and to protect the algae species from contamination. The semi-closed loop diesel photobioreactor includes a container that can be designed in a variety of shapes with a tube design preferred, and containing a liquid culture medium for cultivating photosynthetic organisms. The system can utilize natural light and can also deploy an innovative lighting system integrated into the photobioreactor container. The diesel photobioreactor system also has one or more cleaning devices mounted within the container for cleaning the surface of the photobioreactor container. | 2010-03-04 |
| 20100055766 | MICROFLUIDIC CARTRIDGE FOR SEPARATING TARGET MOLECULES, AND SEPARATOR AND METHOD OF SEPARATING TARGET MOLECULES USING SAME - A microfluidic cartridge includes a capture portion capturing target material on surfaces of nonmagnetic particles; and a separating portion separating target molecules from the target material captured on the surfaces of the particles. The microfluidic cartridge is mounted on an adaptor that is rotated by a rotating unit in order to separate a fluid including the target molecules from the particles through centrifugal force. | 2010-03-04 |
| 20100055767 | BIO-ENERGY SYSTEM AND APPARATUS - A bio-energy system includes a waste collecting station at which raw waste material such as municipal waste, household waste and the like is collected. The waste is delivered through a rotating organic material digester in a controlled manner for converting the organic waste material content of the raw waste to a bio-fuel. Treated material discharged from the digester is passed through a screen to remove any inorganic materials, leaving the bio-fuel. The bio-fuel is dried at a drying station and then delivered to a boiler for combustion to generate energy. | 2010-03-04 |
| 20100055798 | Degenerate Nucleobase Analogs - The present invention relates to novel degenerate nucleobase analogs and degenerate nucleobase oligomers derived therefrom, and methods of using such degenerate nucleobase oligomers. | 2010-03-04 |
| 20100055799 | TEST AGENT FOR DIAGNOSING DYSPEPSIA - The present invention provides a composition for measuring the gastric-emptying function and a method for measuring the gastric-emptying function effectively usable in diagnosing dyspepsia. The present invention also provides a dyspepsia diagnostic agent, a method for diagnosing dyspepsia, and a method for measuring the treatment effect on a patient suffering from gastrointestinal disorders caused by insufficiencies in the gastric-emptying function (including a pharmacotherapy). One of the main features of the composition for measuring the gastric-emptying function of the present invention is that a pyrimidine compound, which is converted to a labeled CO | 2010-03-04 |
| 20100055800 | Compositions for Chemiluminescent Detection of Hydrogen Peroxide - Methods and compound useful for detecting a source of hydrogen peroxide are disclosed wherein a signalling compound of the formula: | 2010-03-04 |
| 20100055801 | SENSOR FOR DETECTING AND DIFFERENTIATING CHEMICAL ANALYTES - A sensor for detecting and differentiating chemical analytes includes a microscale body having a first end and a second end and a surface between the ends for adsorbing a chemical analyte. The surface includes at least one conductive heating track for heating the chemical analyte and also a conductive response track, which is electrically isolated from the heating track, for producing a thermal response signal from the chemical analyte. The heating track is electrically connected with a voltage source and the response track is electrically connected with a signal recorder. The microscale body is restrained at the first end and the second end and is substantially isolated from its surroundings therebetween, thus having a bridge configuration. | 2010-03-04 |
| 20100055802 | Analysis using separation combined with chemical conversion followed by optical spectroscopy - The present invention relates to the separation, quantitative measurement, and analysis of trace species using a combination of three steps in succession. First, trace species are separated from other species that are present. Second, the trace species are chemically modified to convert them into specific species that are advantageous for the third and final step. In this last step, cavity enhanced optical detection of the converted species is performed to detect and measure the concentrations of the species of interest. Because the last step has spectroscopic resolution, the concentration of isotopologues in each converted species can be determined. Further processing can provide the ratios between pairs of isotopologues, in particular the ratio of the rare isotopologues to the most abundant isotopologue. | 2010-03-04 |
| 20100055803 | METHOD AND APPARATUS FOR DETECTING MOLECULES - A method and apparatus for detecting a target molecule in a sample are disclosed. The method optionally includes, but is not limited to, contacting the sample with a substrate having a metallic surface and receptors configured to bind to a target molecule, optionally in the presence of one or more metallic nanoparticles also including receptors configured to bind to a target molecule. The method optionally further includes dispersing a dye over the substrate; and applying a magnetic field to the substrate. | 2010-03-04 |
| 20100055804 | METHOD FOR PATTERNING SEMICONDUCTOR DEVICE HAVING MAGNETIC TUNNELING JUNCTION STRUCTURE - A method for patterning a semiconductor device includes forming a lower electrode conductive layer over a substrate, forming a stack structure including a lower electrode conductive layer, a first ferromagnetic layer, an insulation layer and a second ferromagnetic layer over a substrate, forming an upper electrode conductive layer used as a first hard mask over the stack structure, forming a second hard mask layer over the upper electrode conductive layer, selectively etching the second hard mask layer to form a second hard mask pattern, etching the upper electrode conductive layer using the second hard mask pattern as an etch barrier to form an upper electrode, and etching the stack structure including the lower electrode conductive layer, the first ferromagnetic layer, the insulation layer and the second ferromagnetic layer by at least using the upper electrode as an etch barrier. | 2010-03-04 |
| 20100055805 | SEMICONDUCTOR DEVICE MANUFACTURING METHOD - A semiconductor device manufacturing method includes forming a first film made of a first metal to an upper portion of a substrate, forming a second film made of an amorphous metal oxide or an microcrystalline metal oxide on the first film, subjecting the second film to a heat treatment, subjecting the second film after the heat treatment to a reduction treatment, forming a third film made of a ferroelectric material on the second film, and forming a fourth film made of a second metal on the third film. | 2010-03-04 |
| 20100055806 | Piezoelectrically Actuated Ultrananocrystalline Diamond Tip Array Integrated With Ferroelectric Or Phase Change Media For High-Density Memory - A compact large density memory piezoactuated storage device and process for its fabrication provides an integrated microelectromechanical (MEMS) and/or nanoelectromechanical (NEMS) system and structure that features an integrated large density array of nanotips made of wear-resistant conductive ultrananocrystalline diamond (UNCD) in which the tips are actuated via a piezoelectric thin film integrated with the UNCD tips. The tips of the special piezoactuated storage device effectively contact an underlying metal layer (top electrode) deposited on a polarizable ferroelectric layer that is grown on top of another metal layer (bottom electrode) to form a ferroelectric capacitor. Information is imprinted in the ferroelectric layer by the polarization induced by the application of a voltage pulse between the top and bottom electrodes through the conductive UNCD tips. This integrated microelectromechanical (MEMS) and/or nanoelectromechanical (NEMS) system and structure can be efficiently used to imprint data in the ferroelectric layer for memory storage with high density in the gigabit (Gb) to terabit (Tb) range. An alternative memory media to the ferroelectric layer can be a phase change material that exhibits two orders of magnitude difference in electrical resistance between amorphous and crystalline phases. | 2010-03-04 |
| 20100055807 | PLASMA ASHING APPARATUS AND ENDPOINT DETECTION PROCESS - A plasma ashing apparatus for removing organic matter from a substrate including a low k dielectric, comprising a first gas source; a plasma generating component in fluid communication with the first gas source; a process chamber in fluid communication with the plasma generating component; an exhaust conduit in fluid communication with the process chamber; wherein the exhaust conduit comprises an inlet for a second gas source and an afterburner assembly coupled to the exhaust conduit, wherein the inlet is disposed intermediate to the process chamber and an afterburner assembly, and wherein the afterburner assembly comprises means for generating a plasma within the exhaust conduit with or without introduction of a gas from the second gas source; and an optical emission spectroscopy device coupled to the exhaust conduit comprising collection optics focused within a plasma discharge region of the afterburner assembly. An endpoint detection process for an oxygen free and nitrogen free plasma process comprises monitoring an optical emission signal of an afterburner excited species in an exhaust conduit of the plasma asher apparatus. The process and apparatus can be used with carbon and/or hydrogen containing low k dielectric materials. | 2010-03-04 |
| 20100055808 | SUBSTRATE PROCESSING APPARATUS AND METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE - A substrate processing apparatus for executing a predetermined process on a substrate loaded into a process chamber by running a recipe containing a plurality of steps is provided. The recipe includes a process step of processing the substrate, and a leak check step executed before the process step to check whether a leak occurs inside the process chamber, and the substrate processing apparatus includes a main control unit configured to execute the process step while keeping an error that occurs in the leak check step. | 2010-03-04 |
| 20100055809 | PROCESS OF FABRICATING A WORKPIECE USING A TEST MASK - A product workpiece can be processed to form product dice. A test mask can allow intentional changes to be made to a feature on the product workpiece to examine how the altered feature performs. Use of the test mask may be used or not used based on the needs or desires of skilled artisans. By using the test mask, a separate dedicated test structure is not required to be formed in a scribe lane or within an area that could otherwise be used for a product die. Thus, the sampling level by using the test mask can be varied. Also, separate test workpieces, which may not be processed using a significantly different process flow or at significantly different times as compared to product workpieces, are not required. The product workpiece with the altered feature can be electrically tested without the need to form test or bond pads. | 2010-03-04 |
| 20100055810 | MASK FOR THIN FILM DEPOSITION AND METHOD OF MANUFACTURING OLED USING THE SAME - A mask for thin film deposition used in forming an organic thin film or a conductive layer in an organic light emitting device is disclosed. In one embodiment, the mask includes i) a base member, ii) a plurality of slits configured to penetrate through the base member, wherein the plurality of slits have a predetermined length and extend in a first direction, wherein the plurality of slits comprise an outermost slit positioned in an outermost in a second direction having a predetermined angle with respect to the first direction, and wherein the outermost slit comprises two sub-slits separated from each other and iii) a rib supporting part formed between and contacting the two sub-slits, wherein the rib supporting part extends from a rib which is adjacent to the outermost slit. | 2010-03-04 |
| 20100055811 | METHOD OF MAKING A SEMICONDUCTOR CHIP ASSEMBLY WITH A POST/BASE HEAT SPREADER AND A SUBSTRATE - A method of making a semiconductor chip assembly includes providing a post and a base, mounting an adhesive on the base including inserting the post through an opening in the adhesive, mounting a substrate on the adhesive including inserting the post into an aperture in the substrate to form a gap in the aperture between the post and the substrate, then flowing the adhesive into and upward in the gap, solidifying the adhesive, then mounting a semiconductor device on a heat spreader that includes the post and the base, electrically connecting the semiconductor device to the substrate and thermally connecting the semiconductor device to the heat spreader. | 2010-03-04 |
| 20100055812 | METHOD OF MAKING A SEMICONDUCTOR CHIP ASSEMBLY WITH A POST/BASE HEAT SPREADER AND A CONDUCTIVE TRACE - A method of making a semiconductor chip assembly includes providing a post and a base, mounting an adhesive on the base including inserting the post into an opening in the adhesive, mounting a conductive layer on the adhesive including aligning the post with an aperture in the conductive layer, then flowing the adhesive into and upward in a gap located in the aperture between the post and the conductive layer, solidifying the adhesive, then providing a conductive trace that includes a pad, a terminal and a selected portion of the conductive layer, mounting a semiconductor device on a heat spreader that includes the post and the base, electrically connecting the semiconductor device to the conductive trace and thermally connecting the semiconductor device to the heat spreader. | 2010-03-04 |
| 20100055813 | Method of Packaging Light Emitting Diode on Through-Hole Substrate - In a method of packaging a light emitting diode on a through-hole substrate, through holes are created and a wire bonded light emitting diode (LED) chip is set on the substrate, and a lens is set on the through holes and the wire bonded LED chip. The through holes are provided for filling a phosphor into the lens and extracting air in the lens, so that the phosphor can be coated uniformly on the wire bonded LED chip. After the phosphor is solidified, the packaging of the LED is completed. The method can produce a desired shape of the phosphor while the cost is being taken into consideration, and thus the invention can help manufacturers to produce an accurate shape of the phosphor to provide an LED light source of a better quality without involving a complicated procedure. | 2010-03-04 |
| 20100055814 | METHOD OF MANUFACTURING LIGHT EMITTING DIODE DEVICE - A method of manufacturing light-emitting diode device has steps of isolating a light-emitting side of an LED chip from a wire-bonding region by disposing partition panels on the wire-bonding region and coating phosphors on the light-emitting side of the LED chip in a phosphor-coating process. The method can be applied to manufacturing LED device having a flip chip structure or a vertical chip structure. According to the method, a white LED device can be directly manufactured without adopting a phosphor package technique, and thereby a whole package process of the white LED device is simplified. | 2010-03-04 |
| 20100055815 | METHOD OF MANFUACTURING LENS FOR LIGHT EMITTING DIODE PACKAGE - The present invention relates to a method of manufacturing a lens for a light emitting diode package and can reduce a manufacture cost through reduction of material loss and improve productivity through a simple process without an additional device by freely implementing a final lens shape by curing liquid resin in multi-steps. | 2010-03-04 |
| 20100055816 | Light Emitting Device Manufacturing Apparatus and Method - A disclosed light-emitting-device manufacturing apparatus for manufacturing a light emitting device by forming, on an in-process substrate, an organic layer including an emitting layer includes multiple processing chambers to which the in-process substrate is sequentially transferred to be subjected to multiple substrate processing steps; and multiple substrate transfer chambers, each of which is connected to a different one of the processing chambers. A substrate holding container configured to contain the in-process substrate is sequentially connected to the substrate transfer chambers in order so that the in-process substrate is sequentially transferred to the processing chambers to be subjected to the substrate processing steps. | 2010-03-04 |
| 20100055817 | METHOD OF MANUFACTURING ARRAY SUBSTRATE OF HORIZONTAL ELECTRIC FIELD TYPE TRANSREFLECTIVE LIQUID CRYSTAL DISPLAY - A method of manufacturing an array substrate of horizontal electric field type transreflective LCD is provided in the invention. An array substrate of liquid crystal display is obtained by using one full tone mask and two dual tone masks according to the method. Specifically, the gate line, the gate electrode and the display region are formed by using a full tone mask, the thin film transistor, the transmissive region and the reflective region on the electrode are formed by using a first dual tone mask, and the via hole and the electrode with slits are formed by using a second dual tone mask. | 2010-03-04 |
| 20100055828 | PROCESS AND PASTE FOR CONTACTING METAL SURFACES - For production of an electrically conductive or thermally conductive connection for contacting two elements, an elemental metal, in particular silver, is formed from a metal compound, in particular a silver compound, between the contact surfaces. In this production, the processing temperature for the use of a silver solder can be decreased below 240° C. and the processing pressure can be reduced to normal pressure. A contacting paste for this purpose contains a metal compound, in particular a silver compound, which decomposes below 400° C. while forming elemental silver. As a result, a metal is generated in situ from a chemical compound for producing a contact, which is usable above the temperature necessary for its production. | 2010-03-04 |
| 20100055829 | APPARATUS AND METHODS FOR FORMING PHASE CHANGE LAYER AND METHOD OF MANUFACTURING PHASE CHANGE MEMORY DEVICE - Provided are apparatus and methods for forming phase change layers, and methods of manufacturing a phase change memory device. A source material is supplied to a reaction chamber, and purges from the chamber. A pressure of the chamber is varied according to the supply of the source material and the purge of the source material. | 2010-03-04 |
| 20100055830 | I-SHAPED PHASE CHANGE MEMORY CELL - A memory device includes two electrodes, vertically separated and having mutually opposed contact surfaces, between which lies a phase change cell. The phase change cell includes an upper phase change member, having a contact surface in electrical contact with the first electrode; a lower phase change member, having a contact surface in electrical contact with the second electrode; and a kernel member disposed between and in electrical contact with the upper and lower phase change members. The phase change cell is formed of material having at least two solid phases, and the lateral extent of the upper and lower phase change members is substantially greater than that of the kernel member. An intermediate insulating layer is disposed between the upper and lower phase change members adjacent to the kernel member. | 2010-03-04 |
| 20100055831 | PHASE CHANGEABLE MEMORY CELL ARRAY REGION AND METHOD OF FORMING THE SAME - A phase changeable memory cell array region includes a lower interlayer insulating layer disposed on a semiconductor substrate. The region also includes a plurality of conductive plugs disposed through the lower interlayer insulating layer. The region also includes a phase changeable material pattern operably disposed on the lower interlayer insulating layer, the phase changeable pattern covering at least two of the plurality of conductive plugs, wherein the phase changeable material pattern includes a plurality of first regions in contact with one or more of the plurality of conductive plugs and at least one second region interposed between the plurality of the first regions, wherein the at least one second region has a lower thermal conductivity than the plurality of first regions. The phase changeable memory cell array region also includes an upper interlayer insulating layer covering at least one of the phase changeable material pattern and the lower interlayer insulating layer. The region also includes conductive patterns disposed through the upper interlayer insulating layer and electrically connected to a plurality of predetermined regions of the plurality of first regions. | 2010-03-04 |
| 20100055832 | METHOD FOR MANUFACTURING SEMICONDUCTOR DEVICE - To provide a method for manufacturing a thin film transistor in which contact resistance between an oxide semiconductor layer and source and drain electrode layers is small, the surfaces of the source and drain electrode layers are subjected to sputtering treatment with plasma and an oxide semiconductor layer containing In, Ga, and Zn is formed successively over the source and drain electrode layers without exposure of the source and drain electrode layers to air. | 2010-03-04 |
| 20100055833 | METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE IN WHICH FUNCTIONAL PORTION OF ELEMENT IS EXPOSED - A method of manufacturing a semiconductor device includes: forming a first resin layer on a wafer having a light receiving portion; patterning the first resin layer into a predetermined shape and forming a first resin film on the light receiving portion; dividing the wafer into light receiving elements; mounting the light receiving elements on an upper surface of a lead frame; a sealing step of forming a sealing resin layer around the first resin film; and removing the first resin film such that a portion of the light receiving element is exposed to the outside, and in the sealing step, the upper surface of the first resin film is flush with the upper surface of the sealing resin layer, or the upper surface of the first resin film is higher than the upper surface of the sealing resin layer. | 2010-03-04 |
| 20100055834 | SEMICONDUCTOR DEVICE MANUFACTURING METHOD - An improved method of manufacturing a semiconductor device. The resulting semiconductor device operates properly even when a plurality of semiconductor chips is mounted. One or more semiconductor chips are mounted on the bottom surface of a mounting substrate, the semiconductor chips are fixed to a supporting substrate with adhesive, and then the semiconductor chips are sealed with resin. Subsequently, another semiconductor chips are mounted on the top surface of the mounting substrate. | 2010-03-04 |
| 20100055835 | METHOD OF STACKING AND INTERCONNECTING SEMICONDUCTOR PACKAGES VIA ELECTRICAL CONNECTORS EXTENDING BETWEEN ADJOINING SEMICONDUCTOR PACKAGES - An electronic component is disclosed including a plurality of stacked semiconductor packages. A first such embodiment includes an internal connector for electrically coupling the stacked semiconductor packages. A second such embodiment includes an external connector for electrically coupling the stacked semiconductor packages. | 2010-03-04 |
| 20100055836 | METHOD OF STACKING AND INTERCONNECTING SEMICONDUCTOR PACKAGES VIA ELECTRICAL CONNECTORS EXTENDING BETWEEN ADJOINING SEMICONDUCTOR PACKAGES - An electronic component is disclosed including a plurality of stacked semiconductor packages. A first such embodiment includes an internal connector for electrically coupling the stacked semiconductor packages. A second such embodiment includes an external connector for electrically coupling the stacked semiconductor packages. | 2010-03-04 |
| 20100055837 | MULTI-CHIP MODULE AND METHODS - A substrate includes first and second regions over which first and second semiconductor devices are to be respectively positioned. The first region is located at least partially within the second region. Contact areas are located external to the first region but within the second region. In one embodiment, in which semiconductor devices are to be stacked over and secured to the substrate in a flip-chip type arrangement, the contact areas correspond to bond pads of an upper, second semiconductor device, while other contact areas located within the first region correspond to bond pads of a lower, first semiconductor device. In another embodiment, the contact areas correspond to bond pads of the first semiconductor device, which are electrically connected thereto by way of laterally extending discrete conductive elements, while other contact areas that are located external to the second region correspond to bond pads of the upper, second semiconductor device. | 2010-03-04 |
| 20100055848 | Inspection of underfill in integrated circuit package - In inspecting for quality of underfill material dispensed in an IC package, a camera image is captured for the IC package having the underfill material dispensed between an IC die and a package substrate. A data processor analyzes the camera image to determine an occurrence of an unacceptable condition of the underfill material. Pre-heating and/or post-heating of the package substrate before and/or after dispensing the underfill material by a contact-less heater ensures uniform spreading of the underfill material. | 2010-03-04 |
| 20100055849 | METHOD OF ENCAPSULATING WIRE BONDS - A method encapsulating wire bonds that extend between a die and conductors on a supporting substrate, by contacting an edge of a profiling blade with the encapsulant material to form a bead of the encapsulant on the edge, positioning the edge such that the bead contacts the die and, moving the profiling blade relative to the die to cover the wire bonds with the encapsulant. Wiping the encapsulant over the wire bonds with a profiling blade provides control of the encapsulant front as well as the height of the encapsulant relative to the die. The movement of the profiling surface relative to the die can closely controlled to shape the encapsulant to a desired form. Using the example of a printhead die, the encapsulant can be shaped to present an inclined face rising from the nozzle surface to a high point over the wire bonds. This can be used by the printhead maintenance facilities to maintain contact pressure on the wiping mechanism. However, it will be appreciated that the encapsulant can be shaped to have ridges, gutters, grooves and so on by using a particular shape of profiling blade edge and relative movement with the die. | 2010-03-04 |
| 20100055850 | METHODS FOR FABRICATING PIXEL STRUCTURE, DISPLAY PANEL AND ELECTRO-OPTICAL APPARATUS - A substrate having a switching device and a storage capacitor thereon is provided. A protective layer is formed on the substrate. A patterned organic material layer is formed on the protective layer, wherein bump patterns are formed on a part of the patterned organic material layer and the patterned organic material layer has first openings to expose the partial protective layer. A reflective layer is formed on the patterned organic material layer and the exposed protective layer. A first patterned photoresist layer is formed on a part of the reflective layer, wherein the first patterned photoresist layer has second openings to expose a part of the reflective layer. The first patterned photoresist layer is used as an etching mask to form a first contact hole and a second contact hole. The first patterned photoresist layer is removed. A pixel electrode is formed on the patterned organic material layer. | 2010-03-04 |
| 20100055851 | PHOTORESIST COMPOSTION, METHOD FOR FORMING THIN FILM PATTERNS, AND METHOD FOR MANUFACTURING A THIN FILM TRANSISTOR USING THE SAME - The present invention relates to a photoresist composition that comprises a resin that is represented by Formula 1, a method for forming a thin film pattern, and a method for manufacturing a thin film transistor array panel by using the same. | 2010-03-04 |
| 20100055852 | SEMICONDUCTOR DEVICE AND METHOD OF FABRICATING THE SAME - There is disclosed a method of fabricating TFTs having reduced interconnect resistance by having improved contacts to source/drain regions. A silicide layer is formed in intimate contact with the source/drain regions. The remaining metallization layer is selectively etched to form a contact pad or conductive interconnects. | 2010-03-04 |
| 20100055853 | METHOD FOR MANUFACTURING PIXEL STRUCTURE - A method for manufacturing a pixel structure is provided. A gate and a gate insulating layer are sequentially formed on a substrate. A semiconductor layer and a second metal layer are sequentially formed on the gate insulating layer. The semiconductor layer and the second metal layer are patterned to form a channel layer, a source and a drain by using a patterned photoresist layer formed thereon, wherein the source and drain are disposed on a portion of the channel layer. The gate, channel, source and drain form a thin film transistor. A passivation layer is formed on the patterned photoresist layer, the gate insulating layer and the thin film transistor. Then, the patterned photoresist layer is removed, such that the passivation layer thereon is removed simultaneously to form a patterned passivation layer and the drain is exposed. A pixel electrode is formed on the patterned passivation layer and the drain. | 2010-03-04 |
| 20100055854 | Method of manufacturing semiconductor device - A method of manufacturing a semiconductor device includes forming a trench in an interlayer dielectric film on the semiconductor substrate, the trench reaching a semiconductor substrate and having a sidewall made of silicon nitride film; depositing a gate insulation film made of a HfSiO film at a temperature within a range of 200 degrees centigrade to 260 degrees centigrade, so that the HfSiO film is deposited on the semiconductor substrate which is exposed at a bottom surface of the trench without depositing the HfSiO film on the silicon nitride film; and filling the trench with a gate electrode made of metal. | 2010-03-04 |
| 20100055855 | Method of preventing sliding in manufacturing semiconductur device - A method for manufacturing transistors includes forming a gate electrode and a side wall insulating film over the device-forming surface of a silicon substrate. A source/drain region is formed in a periphery of the gate electrode on the silicon substrate. A Ni film is formed on the entire device-forming surface of the silicon substrate that is provided with a side wall formed thereon, and then, a reaction of the silicon substrate with the Ni film on the source/drain region by heating the silicon substrate. | 2010-03-04 |
| 20100055856 | Method of forming oxide layer, and method of manufacturing semiconductor device - A method of forming an oxide layer on a trench, a method of forming a semiconductor device, and a semiconductor device, the method of forming an oxide layer on a trench including forming a first trench in a first portion of a substrate and a second trench in a second portion of the substrate, the first portion being different from the second portion, performing a plasma doping process on at least one of the first portion and the second portion to implant an impurity therein, and performing an oxidation process to form an oxide layer on the substrate, a thickness of the oxide layer being determined by the impurity implanted in the substrate. | 2010-03-04 |
| 20100055857 | METHOD OF FORMING A POWER DEVICE - A method of forming a power device includes providing a substrate, a semiconductor layer having at least a trench and being disposed on the substrate, a gate insulating layer covering the semiconductor layer, and a conductive material disposed in the trench, performing an ion implantation process to from a body layer, performing a tilted ion implantation process to from a heavy doped region, forming a first dielectric layer overall, performing a chemical mechanical polishing process until the body layer disposed under the heavy doped region is exposed to form source regions on the opposite sides of the trench, and forming a source trace directly covering the source regions disposed on the opposite sides of the trench. | 2010-03-04 |
