| 09th week of 2016 patent applcation highlights part 28 |
| Patent application number | Title | Published |
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| 20160060624 | HUNTINGTON'S DISEASE THERAPEUTIC COMPOUNDS - The present invention is directed to RNA interference (RNAi) molecules targeted against a Huntington's disease nucleic acid sequence, and methods of using these RNAi molecules to treat Huntington's disease. | 2016-03-03 |
| 20160060625 | MODULATION OF APOLIPOPROTEIN CIII (APOCIII) EXPRESSION - Provided herein are methods, compounds, and compositions for reducing expression of ApoCIII mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for increasing HDL levels and/or improving the ratio of TG to HDL and reducing plasma lipids and plasma glucose in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease or metabolic disorder, or a symptom thereof. | 2016-03-03 |
| 20160060626 | MODULATION OF ANGIOPOIETIN-LIKE 3 EXPRESSION - Provided herein are methods, compounds, and compositions for reducing expression of an ANGPTL3 mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for reducing plasma lipids, plasma glucose and atherosclerotic plaques in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease or metabolic disease, or a symptom thereof. | 2016-03-03 |
| 20160060627 | Pharmaceutical Composition for Inhibition of Disease-inducing microRNAs - The invention provides pharmaceutical compositions comprising short single stranded oligonucleotides, of length of between 8 and 17 nucleobases which are complementary to human microRNAs. The short oligonucleotides are particularly effective at alleviating miRNA repression in vivo. It is found that the incorporation of high affinity nucleotide analogues into the oligonucleotides results in highly effective anti-microRNA molecules which appear to function via the formation of almost irreversible duplexes with the miRNA target, rather than RNA cleavage based mechanisms, such as mechanisms associated with RNaseH or RISC. | 2016-03-03 |
| 20160060628 | DOWN-REGULATING GENE EXPRESSION IN INSECT PESTS - The present invention relates to genetic control of infestation by insect pest species, particularly prevention and/or control of pest infestation of plants, using interfering ribonucleic acid (RNA) molecules. Compositions and combinations containing the interfering RNA molecules of the invention for use in topical applications, for example in the form of insecticides. | 2016-03-03 |
| 20160060629 | SYNTHETIC MIMICS OF MIR-124 - Embodiments concern methods and compositions involving miR-124 mimics. In some embodiments, there are double-stranded RNA molecules with modified nucleotides having an active strand with a miR-124 sequence and a complementary passenger strand. | 2016-03-03 |
| 20160060630 | METHOD FOR EVALUATING REDOX ACTIVITY OF NUCLEIC ACID MOLECULE AND NUCLEIC ACID MOLECULE HAVING REDOX ACTIVITY - The present invention provides a novel technique by which the redox activity of a nucleic acid molecule can be evaluated. An evaluation method of the present invention includes: a detection step of electrochemically detecting a redox reaction to a substrate, the redox reaction being catalyzed by a nucleic acid molecule to be evaluated, using a device that electrochemically detects a redox reaction; and an evaluation step of evaluating redox activity of the nucleic acid molecule from a result of the detection of the redox reaction. As the device, a device in which a base provided with a detection portion is included, the detection portion includes an electrode system, and the nucleic acid molecule to be evaluated is arranged on the base is used. In the present invention, it is preferred that a plurality of kinds of nucleic acid molecule to be evaluated is arranged on the base, and the plurality of kinds of nucleic acid molecules to be evaluated is evaluated by a single device. | 2016-03-03 |
| 20160060631 | DNA APTAMERS BINDING THE HISTIDINE TAG AND THEIR APPLICATION - A DNA aptamer was obtained which has an affinity for His-tag, and contains a nucleotide sequence selected from SEQ ID No. 1 and SEQ ID No. 2, which has clear applications. | 2016-03-03 |
| 20160060632 | MODIFIED TGF-BETA2 OLIGONUCLEOTIDES - The invention refers to an oligonucleotide consisting of 10 to 18 nucleotides of selected regions of the TGF-beta2 nucleic acid sequence, which comprises modified nucleotides such as LNA, ENA, polyalkylene oxide-, 2′-fluoro, 2′-O-methoxy and/or 2′-O-methyl modified nucleotides. The invention further relates to pharmaceutical compositions comprising such oligonuc-leotide, wherein the composition or the oligonucleotide is used in the prevention and/or treatment of a malignant and/or benign tumor, an immunologic disease, fibrosis, or an ophthalmic disease such as dry eye, glaucoma or posterior capsular opacification (PCO). | 2016-03-03 |
| 20160060633 | COMPOSITION COMPRISING INHIBITOR AGAINST PAPSS2 GENE OR PROTEIN ENCODED BY GENE FOR INDUCING SENESCENCE IN TUMOR CELLS AND METHOD FOR INDUCING SENESCENCE IN TUMOR CELLS USING THE SAME - Provided is a composition for inducing tumor cell senescence and a method for inducing tumor cell senescence using the same. The composition can inhibit a PAPSS2 gene in a tumor cell to thereby induce senescence of the tumor cell, and if the composition is used concurrently with irradiation of the tumor cell, the composition can improve the sensitivity of the tumor cell to radiation. | 2016-03-03 |
| 20160060634 | Method For Treating Breast Cancer By Targeting Breast Cancer Stem Cell - The present invention relates to a composition for inhibiting growth of cancer stem cells, which includes an EXT1, LDHB, CD109, EFEMP2, RASIP1 or SERPINE1 gene expression inhibitor as an active ingredient, and a method of treating cancer using the same. The composition has targeted therapeutic activities against cancer stem cells important for resistance, metastasis and recurrence of breast cancer, and thus can be useful in fundamentally treating, preventing or alleviating cancer such as breast cancer by directly inhibiting expression of EXT1, LDHB, CD109, EFEMP2, RASIP1 or SERPINE1 which are very important for growth of the cancer stem cells. | 2016-03-03 |
| 20160060635 | RECOMBINANT MICROORGANISMS HAVING A METHANOL ELONGATION CYCLE (MEC) - Provided are microorganisms that catalyze the synthesis of chemicals and biochemicals from a methanol, methane and/or formaldehyde. Also provided are methods of generating such organisms and methods of synthesizing chemicals and biochemicals using such organisms. | 2016-03-03 |
| 20160060636 | NRPS-PKS GENE CLUSTER AND ITS MANIPULATION AND UTILITY - A nucleic acid molecule comprises a nucleotide sequence: as shown in SEQ ID No. 1, which is the complement of SEQ ID No. 1, which is degenerate with SEQ ID No. 1, or which has at least 85% sequence identity with SEQ ID No. 1, or which is a part of such a sequence. The nucleic acid molecule encodes or is a complementary to a nucleic acid molecule encoding one or more polypeptides, or comprises or is complementary to a nucleic acid molecule comprising one or more genetic elements, having functional activity in the synthesis of a polyketide-based or macrolactam molecule. The nucleic acid molecule may be used to prepare a modified BE-14106 biosynthetic gene cluster for the preparation of a modified BE-14106 molecule. | 2016-03-03 |
| 20160060637 | Improved Gene Targeting and Nucleic Acid Carrier Molecule, In Particular for Use in Plants - The present invention relates to a nucleic acid carrier molecule, comprising the general formula M-S | 2016-03-03 |
| 20160060638 | PRECURSOR-DIRECTED BIOSYNTHESIS OF 5-HYDROXYTRYPTOPHAN - The invention provides compounds, compositions, non-naturally occurring organisms, and methods useful for production of 5-hydroxytryptophan (5-HTP) in a microbial cell. A microbial system which includes at least one microbial cell, such as a bacterial cell or a yeast cell, is genetically engineered to express all or a portion of non-naturally occurring biosynthetic pathway that catalyzes the conversion of a simple carbon source, such as glucose, to 5-HTP. The invention can result in improved titers of 5-HTP and permits low-cost, large scale production. Methods of making and using the genetically engineered cells are also included in the invention. | 2016-03-03 |
| 20160060639 | Positive-Selection Cloning and Expression Vector Based on the Toxicity of Killin - Here we report the creation of a new positive-selection cloning vector dubbed pKILLIN, which overcomes all of the above pitfalls. The essence behind its high cloning efficiency is the extreme toxicity and small size of the toxic domain of killin, a recently discovered p53 target gene. Insertion inactivation of killin within the multiple cloning site via either blunt- or sticky-end ligation serves not only as a highly efficient cloning trap, but also may allow any cloned genes to be expressed as His-tagged fusion proteins for subsequent purification. Thus, pKILLIN is a versatile positive-selection vector ideal for cloning PCR products, making DNA libraries, as well as routine cloning and bacterial expression of genes. | 2016-03-03 |
| 20160060640 | Coryneform Bacterium and Method for Producing Heterologous Fusion Proteins - The present invention provides a coryneform bacterium having an ability to produce a heterologous fusion protein by secretory production, which has been modified to express a genetic construct for secretory production of the heterologous fusion protein encoding at least a heterologous fusion protein comprising an extein and an intein having an activity of acyl rearrangement. The method for producing proteins modified at the C-terminus is also provided. | 2016-03-03 |
| 20160060641 | MODIFIED FUNGAL HOST CELLS AND METHOD OF USING SAME - Disclosed are modified filamentous fungal cells in which the selective autophagy system of the filamentous fungal cell has been partially or completely inactivated, methods of making such genetically modified filamentous fungal cells, and methods for producing biological products of interest in such modified filamentous fungal cells. Also disclosed are genetically modified filamentous fungal cells having disrupted or deleted atg11 activity, methods of making such genetically modified filamentous fungal cells, and methods for producing biological products of interest in such modified filamentous fungal cells. | 2016-03-03 |
| 20160060642 | G Protein Coupled Receptor Libraries - The present invention relates to a yeast cell expressing a nematode G protein coupled receptor (GPCR), whereby ligand binding to the GPCR results in a detectable signal. In particular, the present invention relates to a yeast library expressing a range of different GPCRs, and to methods of screening said library. | 2016-03-03 |
| 20160060643 | PREMETHYLATION OF DNA FOR HIGH EFFICIENCY TRANSFORMATION OF CYANOBACTERIA - Methods of pre-methylation of foreign DNA to improve genetic transformation in cyanobacterium. Two Type II methyltransferase-encoding genes, i.e., M (sll0729) and C (slr0214), were cloned from the chromosome of | 2016-03-03 |
| 20160060644 | SYSTEM FOR EXPRESSION OF GENES IN PLANTS - The present invention provides trans-complementation systems for expressing gene products in plants. In general, the invention provides systems including a carrier vector and a producer vector, both based on plant viruses. The producer vector is defective for at least one function needed for successful systemic infection of a plant, e.g., replication, cell-to-cell movement, or long distance movement. The carrier vector supplies the missing function in trans. Certain producer vectors lack a functional coat protein coding sequence, in which case the corresponding producer vector supplies coat protein in trans. The invention also provides novel plant viral vectors and methods of use, e.g., to produce polypeptides or active RNAs in plants. | 2016-03-03 |
| 20160060645 | NUCLEIC ACID SEQUENCES ENCODING TRANSCRIPTION FACTORS REGULATING ALKALOID BIOSYNTHESIS AND THEIR USE IN MODIFYING PLANT METABOLISM - Plant metabolism and alkaloid levels can be regulated by transcription factors that regulate the nicotinic alkaloid biosynthetic pathway. In one embodiment, the disclosure provides a transcription factor that negatively regulates alkaloid biosynthesis, such as nicotine biosynthesis. | 2016-03-03 |
| 20160060646 | NUCLEIC ACID SEQUENCES ENCODING TRANSCRIPTION FACTORS REGULATING ALKALOID BIOSYNTHESIS AND THEIR USE IN MODIFYING PLANT METABOLISM - Plant metabolism and alkaloid levels can be regulated by transcription factors that regulate the nicotinic alkaloid biosynthetic pathway. In one embodiment, the disclosure provides a transcription factor that negatively regulates alkaloid biosynthesis, such as nicotine biosynthesis. | 2016-03-03 |
| 20160060647 | DROUGHT TOLERANT PLANTS AND RELATED CONSTRUCTS AND METHODS INVOLVING GENES ENCODING PHOSPHATIDIC ACID PHOSPHATASE (PAP), DTP25 and DTP46 POLYPEPTIDES - Isolated polynucleotides, polypeptides and recombinant DNA constructs useful for conferring drought tolerance are disclosed. The recombinant DNA construct comprises a promoter that is functional in a plant operably linked to a polynucleotide that encodes a PAP, a DTP25 or a DTP46 polypeptide. Also disclosed are methods of utilizing the recombinant DNA construct and compositions (such as plants or seeds) comprising the recombinant DNA construct. | 2016-03-03 |
| 20160060648 | Transgenic Plants with Enhanced Agronomic Traits - This invention provides transgenic plant cells with recombinant DNA for expression of | 2016-03-03 |
| 20160060649 | LETTUCE VARIETY 45-90 RZ - The present invention relates to a | 2016-03-03 |
| 20160060650 | Potato Fertility Restoration - A family 1 cellulose-binding-domain (CBD) encoding gene from | 2016-03-03 |
| 20160060651 | EXPRESSION SYSTEMS - A gene expression system is provided. The system comprises at least one coding sequence to be expressed in an organism, and at least one promoter operably linked thereto. It further comprises at least one splice control sequence which, in cooperation with a spliceosome, mediates alternative splicing of RNA transcripts of the coding sequence. The mediation of alternative splicing is in a sex-specific, stage-specific, germline-specific and tissue-specific manner. | 2016-03-03 |
| 20160060652 | MICROVESICLE AND METHOD FOR PRODUCING THE SAME - The present invention provides a method for producing microvesicles comprising a transgene product and/or a lentiviral RNA comprising a transgene, comprising the steps of: culturing a cell into which the transgene has been introduced using a lentiviral vector in vitro to extracellularly release microvesicles comprising the transgene product and/or the lentiviral RNA comprising the transgene, wherein said lentiviral vector is deficient in at least one structural protein gene and comprises the transgene under control of a telomerase reverse transcriptase (TERT) gene promoter in a lentiviral genome sequence, and collecting the microvesicles released; and a microvesicle obtained according to this method and its use. | 2016-03-03 |
| 20160060653 | METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION - The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms. | 2016-03-03 |
| 20160060654 | METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION - The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms. | 2016-03-03 |
| 20160060655 | COMPOSITIONS AND METHODS TO TREAT LATENT VIRAL INFECTIONS - Viral infection is a persistent cause of human disease. Guided nuclease systems target the genomes of viral infections, rendering the viruses incapacitated. | 2016-03-03 |
| 20160060656 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF LYSOSOMAL STORAGE DISEASES - Nucleases and methods of using these nucleases for inserting a sequence encoding a therapeutic protein such as an enzyme into a cell, thereby providing proteins or cell therapeutics for treatment and/or prevention of a lysosomal storage disease. | 2016-03-03 |
| 20160060657 | METHODS AND COMPOSITIONS FOR THE TARGETED MODIFICATION OF A GENOME - Compositions and methods are provided for modifying a genomic locus of interest in a eukaryotic cell, a mammalian cell, a human cell or a non-human mammalian cell using a large targeting vector (LTVEC) comprising various endogenous or exogenous nucleic acid sequences as described herein. Further methods combine the use of the LTVEC with a CRISPR/Cas system. Compositions and methods for generating a genetically modified non-human animal comprising one or more targeted genetic modifications in their germline are also provided. | 2016-03-03 |
| 20160060658 | FERMENTATION SYSTEM FOR DRY MILL PROCESSES - Methods of and system for growing higher and stronger levels of yeast in the Yeast Tank and Fermenter Tank during the fermentation filling cycle are provided. The yeast growth is reconfigured by continuing pumping yeast under the most active conditions while at a lower YCC (yeast cell count) into the Fermenter Tank during a filling period. A measurable and useful parameter, % DT/% Yeast by weight ratio (or “food” to yeast ratio), is introduced (e.g., % DT=glucose), which offers information on the health status of the yeast. | 2016-03-03 |
| 20160060659 | GLUCOSE AND XYLOSE CO-FERMENTING MICROORGANISM THAT EXPRESSES ACTIVE GLUCOAMYLASE - Provided are microorganisms, e.g., the | 2016-03-03 |
| 20160060660 | BIOTECHNOLOGICAL PRODUCTION OF ITACONIC ACID - The present invention provides a novel method and means of producing itaconic acid based on the use of the mammalian Immune response gene 1 (Irg1) and variants to express an enzyme which converts cis-aconitic acid to itaconic acid. The method includes cultivation a host cell comprising the Igr1 gene or variants thereof and obtaining itaconic acid. | 2016-03-03 |
| 20160060661 | PROCESSING BIOMASS - Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful intermediates and products, such as energy, fuels, foods or materials. For example, systems are described that can use feedstock materials, such as cellulosic and/or lignocellulosic materials, to produce an intermediate or product, e.g., by fermentation. | 2016-03-03 |
| 20160060662 | DESATURASES OF A GREEN MICROALGA AND USES THEREOF - Isolated proteins which are at least partially encoded by polynucleotide sequences encoding novel desaturases are provided together with a composition which includes these isolated proteins. A transgenic plant, a transgenic alga, or a transgenic seed transformed by the polynucleotides encoding proteins which are at least partially encoded by novel desaturases are also provided. The invention also includes a process for making a very long-chain polyunsaturated fatty acid in a transformed cell, a transgenic alga, or a transgenic plant expressing the isolated protein or proteins which are at least partially encoded by the polynucleotide sequences encoding novel Δ5, Δ6, or Δ12 desaturases. | 2016-03-03 |
| 20160060663 | PRODUCTION OF FATTY ACIDS ESTERS - A microbial cell is used for producing at least one fatty acid ester, wherein the cell is genetically modified to contain (i) at least one first genetic mutation that enables the cell to produce at least one fatty acid and/or acyl coenzyme A (CoA) thereof by increased enzymatic activity in the cell relative to the wild type cell of malonyl-CoA dependent and malonyl-ACP independent fatty acyl-CoA metabolic pathway, wherein the fatty acid contains at least 5 carbon atoms; and (ii) a second genetic mutation that increases the activity of at least one wax ester synthase in the cell relative to the wild type cell and the wax ester synthase has sequence identity of at least 50% to a polypeptide of SEQ ID NO: 1-8 and combinations thereof or to a functional fragment of any of the polypeptides for catalyzing the conversion of fatty acid and/or acyl coenzyme A thereof to the fatty acid ester. | 2016-03-03 |
| 20160060664 | METHOD FOR IMPROVING THE FERMENTABLE SUGAR YIELD FROM LIGNOCELLULOSIC - The invention relates to processes for the conversion of biomass into carbohydrates, notable fermentable sugars. It provides means and methods for increasing the yield of enzymatic digestion of a biomass, in particular in those cases where cellulose is converted into sugars using a cellulose converting enzyme. More in particular, the invention relates to a method for producing a fermentable sugar from a lignocellulosic material wherein the lignocellulosic material is contacted with a laccase and an enzyme capable of degrading cellulose, either simultaneously or in a sequentially deferred fashion, wherein the laccase is the | 2016-03-03 |
| 20160060665 | HEMICELLULASE ENRICHED COMPOSITIONS FOR ENHANCING HYDROLYSIS OF BIOMASS - Described are compositions and methods relating to cellulase/hemicellulase enzyme blends for improving the enzymatic hydrolysis of cellulosic and hemicellulosic materials, as commonly found in biomass. | 2016-03-03 |
| 20160060666 | THERMOSTABLE XYLANASE BELONGING TO GH FAMILY 10 - A thermostable xylanase having a xylanase catalytic domain including: (A) a polypeptide including the amino acid sequence represented by SEQ ID NO: 1, (B) a polypeptide including an amino acid sequence in which at least one amino acid has been deleted, substituted, or added in the amino acid sequence represented by SEQ ID NO: 1, and having xylanase activity at least under conditions of 85° C. and pH 6.0, or (C) a polypeptide including an amino acid sequence having 80% or greater sequence identity with the amino acid sequence represented by SEQ ID NO: 1, and having xylanase activity at least under conditions of 85° C. and pH 6.0. | 2016-03-03 |
| 20160060667 | CONTINUOUS COUNTERCURRENT ENZYMATIC HYDROLYSIS OF PRETREATED BIOMASS AT HIGH SOLIDS CONCENTRATIONS - The invention provides a continuous process for enzymatic hydrolysis of pretreated biomass, the process comprising: providing a pretreated lignocellulosic biomass feed material containing cellulose; introducing the pretreated lignocellulosic biomass feed material to a mechanical-treatment unit containing one or more decompression regions configured to release pressure; introducing a liquid solution containing cellulase enzymes to one or more decompression regions in the mechanical-treatment unit, wherein the liquid solution enters void spaces between fibers of the pretreated lignocellulosic biomass feed material, to form enzyme-containing cellulose-rich solids; and retaining the enzyme-containing cellulose-rich solids under effective hydrolysis conditions to hydrolyze at least some of the cellulose to glucose. Various apparatus configurations are disclosed for the mechanical-treatment unit. | 2016-03-03 |
| 20160060668 | BIOPROCESSING - Functionalized substrate materials, for example inorganic particles and/or synthetic polymeric particles, are used to enhance bioprocesses such as saccharification and fermentation. | 2016-03-03 |
| 20160060669 | GLUCOSE PRODUCTION METHOD AND GLUCOSE PRODUCED BY SAID METHOD - A glucose production method produces glucose by using excrement from living matter that is disposed as waste, without consuming food resources or agricultural resources, which can stably provide glucose at low cost without being affected by crop yields. | 2016-03-03 |
| 20160060670 | Polypeptides Having Cellobiohydrolase Activity and Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 2016-03-03 |
| 20160060671 | Synthon Formation - This disclosure provides, among other things, a composition comprising: a 5′ exonuclease; a strand-displacing polymerase; and optionally a single strand DNA binding protein and/or a ligase. A method for polynucleotide assembly to form a synthon, as well as a kit for performing the same, are also described. | 2016-03-03 |
| 20160060672 | METHOD AND DEVICE FOR POLYMERASE CHAIN REACTION - Method and apparatus for amplifying a target nucleic acid sequence of a reaction mixture in a Polymerase Chain Reaction (PCR). The method includes contacting the reaction mixture with EMR frequency absorbing particles formed from a material having a transition metal, transition metal oxide or a transition metal hydroxide, or a nitride, a phosphide or an arsenide of a Group III metal doped with the transition metal or a transition metal oxide, or silicon dioxide doped with the transition metal, transition metal oxide, or transition metal hydroxide; and irradiating the EMR absorbing particles with EMR having a frequency of about 200 kHz to 500 THz to amplify the target nucleic acid sequence, wherein the Group III metal is any one of Al, Ga, and In, and the transition metal is any one of Mn, Fe, Co and Cu. | 2016-03-03 |
| 20160060673 | NUCLEIC ACID AMPLIFICATION - Methods and compositions for the amplification of nucleic acids are disclosed. Amplification methods provided herein may be performed under isothermal conditions. Methods and compositions may include reagents such as nucleic acid polymerases, ligases, and primers. | 2016-03-03 |
| 20160060674 | NUCLEIC ACID AMPLIFICATION - Methods and compositions for the amplification of nucleic acids are disclosed. Amplification methods provided herein may be performed under isothermal conditions. Methods and compositions may include reagents such as restriction enzymes, polymerases, ligases, primers, and polynucleotide adaptors. | 2016-03-03 |
| 20160060675 | N-ACETYLHEXOSAMINE-CONTAINING N-GLYCANS IN GLYCOPROTEIN PRODUCTS - The present invention provides methods of evaluating a glycoprotein preparation for the absence, presence or amount of an N-acetylhexosamine glycan, e.g., an N-acetylglucosamine glycan. | 2016-03-03 |
| 20160060676 | Automated Cell Growth/Migration Detection System And Associated Methods - An automated cell growth/migration detection system includes: a container for containing a cell growth/migration matrix/medium into which deposited cells form a cell surface; an image sensor for capturing images; an actuator for incrementally varying distance between the image sensor lens and the cell surface such that the images correspond to varying imaging depths; and an image data processor for processing the images to determine cell growth/migration. An automated cell growth/migration detection method includes: capturing a first image series of a cell surface within a first imaging cycle corresponding to a sequence of imaging depths between the cell surface and an image sensor; capturing an additional image series of the cell surface within each of at least one additional imaging cycle and corresponding to the same sequence of imaging depths; processing each image series for each imaging cycle to determine a clearest-looking image; and determining cell growth/migration from the clearest-looking image. | 2016-03-03 |
| 20160060677 | DEVICE FOR THE MICROBIOLOGICAL DETERMINATION AND ANALYSIS OF A PREPARED LIQUID SAMPLE - The device comprises a microbiologically interactive platform within a liquid-based environment. The platform is positioned by a vertical positioning pin rising centrally from the floor of the device with a floating ball within the device that angles the platform in a specific manner that creates a multiplicity of environments within the device. While the device remains dry, there are no significant microbiological interactions. When a suitably prepared liquid sample is added then there are interactions that allow the determinative analysis of any generated microbiologically generated reactions and responses. These activities are generated primarily from the positioning of the microbiologically interactive platform wherein the platform is formed into an angled profile positioned by the floating ball and the base of the vertical extension pillar. When so positioned, both oxidative and reductive environments are created. Oxidative conditions dominate the platform on the upper side which is directly under the floating ball and where the extension remains exposed. Reductive conditions dominate the lower side of the platform. | 2016-03-03 |
| 20160060678 | SELECTIVE CHROMOGENIC MEDIUM - The invention deals with chromogenic media which are suitable for the selective growth and identification of one or more species of yeast. | 2016-03-03 |
| 20160060679 | COMPOUNDS, SUBSTRATES AND METHODS RELATED TO HISTONE DEACETYLASES - The invention relates to methods for the identification of compounds, peptides and proteins that can act as substrates for histone deacetylases. The invention further relates to compounds of Formula I: | 2016-03-03 |
| 20160060680 | METHOD FOR ANALYZING PLURALITY OF SAMPLES - A diagnostic system performs a first nucleic acid amplification reaction and a second, different nucleic acid amplification reaction. The diagnostic system includes a compartment configured to store at least a first bulk reagent container comprising a first bulk reagent for performing a sample preparation process, and a second bulk reagent container comprising a second bulk reagent for performing the first reaction. The system including a compartment configured to store at least one unit-dose pack comprising a plurality of unit-dose reagents for performing the second reaction. The diagnostic system is configured to perform the sample preparation process using the first bulk reagent on each of a plurality of samples provided to the diagnostic system. The system is configured to perform the first reaction using the second bulk reagent on a first sample subset, and perform the second reaction using the plurality of first unit-dose reagents on a second sample subset. | 2016-03-03 |
| 20160060681 | METHOD AND DEVICE FOR AMPLIFYING AND DETECTING GENE USING GRAPHENE HEATER - Provided is a gene amplifying and detecting device. The gene amplifying and detecting device includes: a gene amplifying chip including a chamber formed therein; a reaction solution filled in the chamber and including a fluorescent material; a light source located at one side of the gene amplifying chip; a light detector located at the other side of the gene amplifying chip; and a graphene heater formed on an inner surface or outer surface of the gene amplifying chip so as to heat the reaction solution. | 2016-03-03 |
| 20160060682 | MULTIPLEXED ANALYSIS OF TARGET NUCLEIC ACIDS - The present invention provides, among other things, methods of detecting target nucleic acid, comprising steps of: a) contacting a sample with one or more capturing probes, each comprising at least one target capturing sequence, under conditions that permit the one or more capturing probes to capture one or more target nucleic acids in the sample; b) amplifying the captured one or more target nucleic acids in a reaction mixture comprising a detectable entity such that the amplified one or more target nucleic acids are labeled with the detectable entity; c) incubating amplification product with a plurality of re-capturing probes such that the amplified one or more target nucleic acids are re-captured by the plurality of the re-capturing probes; and d) detecting signal generated by detectable entity associated with the re-captured amplified one or more target nucleic acids, wherein the presence and/or abundance of the detectable signal indicates the presence and/or abundance of the one or more target nucleic acids in the sample. | 2016-03-03 |
| 20160060683 | NORMALIZATION OF POLYMERASE ACTIVITY - Provided herein is technology relating to the amplification-based detection of nucleic acids and particularly, but not exclusively, to methods and compositions for minimizing variability in the activity between different samples or manufacturing lots of DNA polymerases, such as Taq DNA polymerase. | 2016-03-03 |
| 20160060684 | RAPID SALMONELLA SEROTYPING ASSAY - Processes for the serotype specific detection and identification of one or more | 2016-03-03 |
| 20160060685 | COMPOSITIONS AND METHODS FOR DETECTING NUCLEIC ACID FROM MOLLICUTES - Compositions, reaction mixtures, kits and methods used in amplifying and detecting nucleic acids from various species of the class Mollicutes. Particular regions of the 23S rRNA or its gene have been identified as preferred targets for nucleic acid amplification reactions of a sample suspected containing at least one species of Mollicutes. Some oligomers comprise tag regions, target closing regions, promoter sequences, and/or binding moieties. Samples can be from any source suspected of containing a species of the class Mollicutes. Preferred sample sources include bioreactors, cell lines, cell culture wares and pharmaceutical manufacturing wares. | 2016-03-03 |
| 20160060686 | STRATEGIES FOR HIGH THROUGHPUT IDENTIFICATION AND DETECTION OF POLYMORPHISMS - The invention relates to a method for the high throughput identification of single nucleotide polymorphisms by performing a complexity reduction on two or more samples to yield two or more libraries, sequencing at least part of the libraries, aligning the identified sequences and determining any putative single nucleotide polymorphisms, confirming any putative single nucleotide polymorphism, generating detection probes for the confirmed single nucleotide polymorphisms, subjection a test sample to the same complexity reduction to provide a test library and screen the test library for the presence or absence of the single nucleotide polymorphisms using the detection probe. | 2016-03-03 |
| 20160060687 | METHODS AND COMPOSITIONS TO IDENTIFY, QUANTIFY, AND CHARACTERIZE TARGET ANALYTES AND BINDING MOIETIES - Proximity coupling and sequencing methods to screen identify, validate and/or characterize interactions between analytes and binding moieties are disclosed. Also disclosed herein are proximity coupling methods and sequencing methods to determine or quantify levels of target analytes. The disclosed methods can be multiplexed in two dimensions, and can be used to determine the affinity and specificity of each of a plurality of binding moieties for each of a plurality of target analytes. Also disclosed herein are substrates, arrays, and reagents for use in the methods, and methods of their preparation. | 2016-03-03 |
| 20160060688 | USE OF PROBES FOR MASS SPECTROMETRIC IDENTIFICATION OF MICROORGANISMS OR CELLS AND ASSOCIATED CONDITIONS OF INTEREST - This invention pertains to identifying one or more hybridization probes sequestered within (or optionally released from the intact) cells or microorganisms by mass spectrometry to thereby determine a trait of the cells or microorganisms and/or to identify the cells or microorganisms themselves. The cells or microorganisms can come from a subject and the information obtained from the mass spectrometry analysis may, if clinically relevant, optionally be used to diagnose and/or treat the subject. | 2016-03-03 |
| 20160060689 | AUTOMATED METHOD FOR DETECTING CANCERS AND HIGH GRADE HYPERPLASIAS - Automated methods for detecting cancer and related hyperplasias in biological samples. | 2016-03-03 |
| 20160060690 | DETECTION OF TARGET NUCLEIC ACID SEQUENCE BY PTO CLEAVAGE AND EXTENSION-DEPENDENT NON-HYBRIDIZATION ASSAY - The present invention relates to the detection of a target nucleic acid sequence by a PCE-NH (PTO Cleavage and Extension-Dependent Non-Hybridization) assay. The present invention adopts the occurrence of the inhibition of the hybridization between the HO with the CTO by the formation of the target-dependent extended duplex. Therefore, the present invention may detect target sequences even when the HO is not cleaved. In this regard, the design of the 5′-tagging portion of PTO, CTO and HO sequences may be readily performed and the conditions for reactions may be also easily established. In addition, the detection of the hybrid between the CTO and the HO may be performed in a different vessel from that for the extension of the CTO. | 2016-03-03 |
| 20160060691 | Transposition of Native Chromatin for Personal Epigenomics - Provided herein is a method for analyzing polynucleotides such as genomic DNA. In certain embodiments, the method comprises: (a) treating chromatin isolated from a population of cells with an insertional enzyme complex to produce tagged fragments of genomic DNA; (b) sequencing a portion of the tagged fragments to produce a plurality of sequence reads; and (c) making an epigenetic map of a region of the genome of the cells by mapping information obtained from the sequence reads to the region. A kit for performing the method is also provided. | 2016-03-03 |
| 20160060692 | LABELLED NUCLEOTIDES - Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group. | 2016-03-03 |
| 20160060693 | Compositions and Methods for Intramolecular Nucleic Acid Rearrangement - Aspects of the present invention are drawn to processes for moving a region of interest in a polynucleotide from a first position to a second position with regard to a domain within the polynucleotide, also referred to as a “reflex method”. In certain embodiments, the reflex method results in moving a region of interest into functional proximity to specific domain elements present in the polynucleotide (e.g., primer sites and/or MID). Compositions, kits and systems that find use in carrying out the reflex processes described herein are also provided. | 2016-03-03 |
| 20160060694 | OLIGONUCLEOTIDES FOR CONTROLLING AMPLIFICATION OF NUCLEIC ACIDS - Methods and oligonucleotides are provided for detecting an internal control nucleic acid for qualitative and/or quantitative purposes. | 2016-03-03 |
| 20160060695 | METHOD AND KIT FOR MULTIPLEX DNA TYPING OF HLA GENE - The purpose of the present invention is to provide a method and kit for highly precise DNA typing, in which a high throughput sequencer is used and ambiguity derived from phase ambiguity is eliminated. The present invention provides a method for the DNA typing of HLA, which is characterized by comprising: (1) a step of preparing sets of primers which respectively hybridize specifically to an upstream region and a downstream region of at least 2 genes selected from genes belonging to HLA class I and HLA class II in a human genome sequence, and are capable of amplifying under the same PCR conditions; (2) a step of simultaneously amplifying said at least 2 genes in a test sample (DNA) using the sets of primers in a single container under the same PCR conditions; (3) a step of determining the nucleotide sequences of PCR amplified products; and (4) a step of optionally carrying out a homology search within a database. | 2016-03-03 |
| 20160060696 | METHOD FOR THE IDENTIFICATION BY MOLECULAR TECHNIQUES OF GENETIC VARIANTS THAT ENCODE NO D ANTIGEN (D-) AND ALTERED C ANTIGEN (C+W) - The invention relates to genotyping and blood cell antigen determination. In particular, the invention addresses discriminating the RHD*DIIIa-CE(4-7)-D or RHD*DIIIa-CE(4-7)-D)-like blood type variants, from RHD*DIIIa, RHD*DIVa-2 and other blood type variants. The invention provides methods for genotyping a subject, comprising determining at least 4 markers in a sample that has been obtained from the subject, wherein the markers comprise:
| 2016-03-03 |
| 20160060697 | Compositions and Methods for Evaluating Heart Failure - The present invention provides compositions and kits comprising miRNAs useful for the monitoring or diagnosis of heart disease in an individual. In particular, the compositions of the invention can be used for the prognosis of patients towards the development of left ventricular remodeling having suffered from an acute myocardial infarction. In addition, the present invention provides pharmaceutical compositions for the treatment of left ventricular remodeling. | 2016-03-03 |
| 20160060698 | SIMPLE DETECTION METHOD FOR RNA MODIFICATION, AND METHOD FOR DETECTING TYPE-II DIABETES USING SAID DETECTION METHOD - An object of the present invention is to provide a method for detecting a modification present in RNA using a small amount of RNA sample. Another object of the present invention is to provide a method for detecting a modification present in tRNA, for example, thiomethylation. Still another object of the present invention is to provide a method for detecting the thiomethylation of tRNA, thereby diagnosing human type 2 diabetes or the risk thereof. The present invention is characterized in that, with respect to a modification present in RNA in an RNA sample, cDNA is produced by reverse transcription of RNA using a first primer, and the resulting amount of cDNA is compared with the amount of cDNA produced by reverse transcription of RNA using a second primer, thereby detecting a modification (e.g., thiomethylation) present in RNA. | 2016-03-03 |
| 20160060699 | SLE AND SLE-RELATED DISEASE-ASSOCIATED RISK MARKERS AND USES THEREOF - Provided herein are methods and compositions for identifying subjects, including canine subjects, as having an elevated risk of developing systemic lupus erythematosus (SLE) or an SLE-related immune-mediated rheumatic disorder or having undiagnosed SLE or an SLE-related immune-mediated rheumatic disorder. These subjects are identified based on the presence of gem-line risk markers. | 2016-03-03 |
| 20160060700 | COPY NUMBER VARIATIONS AND AUTOIMMUNE DISEASES - This disclosure describes methods of determining the copy number of FCGR3A and/or FCGR3B in the genome of an individual, which is shown herein to be statistically significantly associated with an increased risk of the individual developing an autoimmune disease. | 2016-03-03 |
| 20160060701 | METHODS FOR PREDICTING RISK OF INTERSTITIAL PNEUMONIA - Disclosed are biomarkers, methods and assay systems for the identification of poor prognosis of interstitial pneumonia (pulmonary fibrosis) in an individual diagnosed with suspected of having interstitial pneumonia. | 2016-03-03 |
| 20160060702 | METHODS, KITS, AND DEVICES FOR DIAGNOSING, PROGNOSING, AND TREATING PSYCHIATRIC DISORDERS IN A PATIENT - Disclosed are methods, kits, and devices for diagnosing and treating psychiatric, disorders and the symptoms thereof. The methods, kits, and devices relate to identifying genetic markers that may be utilized to diagnose and/or prognose a patient and treat the diagnosed and/or prognosed patient by administering a drug the patient based on the genetic marker having been identified. Genetic markers identified in the methods may include HTR2C polymorphisms such as a polymorphism resulting in a Cys23Ser amino acid substitution, an rs3813929 (−759C/T) polymorphism, and an rs518147 (−697G/C) polymorphism). | 2016-03-03 |
| 20160060703 | HAPLOTYPE DETECTION - A method of diagnosing Ankylosing Spondylitis (AS), a spondyloarthropathy, arthritis, psoriasis, type-1 diabetes or a carcinoma comprising typing the ERAP1 haplotype of an individual. | 2016-03-03 |
| 20160060704 | Methods and Compositions for Diagnosis of Glioblastoma or a Subtype Thereof - An isoform-level gene panel is disclosed that can accurately classify a glioblastoma subtype from a tumor sample. Such an isoform level gene panel comprises the 121 to 214 target isoforms identified in Table 1. Also disclosed are reagents for quantitatively detecting the expression or activity of the target isoforms of Table 1 in a patient sample. For example, such ligands can be PCR primer and probes sets. This isoform-level gene panel and reagents for detection of the isoforms are useful in an isoform-level assay for diagnosis of the molecular subtype of a glioblastoma in a patient. The assay employs algorithms and a novel computer program that performs the functions of FIG. | 2016-03-03 |
| 20160060705 | MOLECULAR DIAGNOSTIC TEST FOR CANCER - Methods and compositions are provided for the identification of a molecular diagnostic test for cancer. The test defines a novel DNA damage repair deficient molecular subtype and enables classification of a patient within this subtype. The present invention can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to administration of any chemotherapy. This test may be used in different cancer types and with different drugs that directly or indirectly affect DNA damage or repair, such as many of the standard cytotoxic chemotherapeutic drugs currently in use. In particular, the present invention is directed to the use of certain combinations of predictive markers, wherein the expression of the predictive markers correlates with responsiveness or non-responsiveness to a therapeutic regimen. | 2016-03-03 |
| 20160060706 | METHODS FOR CANCER SCREENING IN LATIN AMERICAN/HISPANIC POPULATIONS - Provided herein are novel methods for diagnosing ovarian and breast cancer risk in a Latin American/Hispanic population based on the presence of specific BRCA1 and/or BRCA2 mutations. | 2016-03-03 |
| 20160060707 | Identification of Cancer Genes by In-Vivo Fusion of Human Cancer Cells and Animal Cells - The present invention concerns compositions and methods for detecting and identifying novel cancer genes. The technique involves in vivo fusion of human cancer cells and animal cells, preferably hamster stromal cells, to form hybrid human cancer-animal cells, followed by identification of genes that are overexpressed in the hybrid cells compared to normal or transformed animal cells. The novel oncogenes or their protein products may be utilized for detection and/or diagnosis of human cancer or for development of new cancer therapies targeted against the novel oncogenes or their expressed proteins. | 2016-03-03 |
| 20160060708 | Method for detecting the risk of early gastric cancer - The present invention discloses the nine biomarkers including HIF1A, FAM84B, CRIP2, GSN, RPL15, DLG1, MAT2A, PGBD2 and ID3 are respectively selected according to their specific and unique expression profile in the gastric cancer cells or gastric cancer tissue. Therefore, the nine biomarkers are related to diagnose gastric cancer, such as detecting early gastric cancer, staging gastric cancer, predicting prognosis of gastric cancer and diagnosing lymph node metastasis. By analyzing the expression value of at least one biomarker of a sample from a subject, the subject can be precisely diagnose the risk about gastric cancer. | 2016-03-03 |
| 20160060709 | NOVEL BIOMARKERS FOR ACUTE MYELOID LEUKEMIA - Methods for the diagnosis of leukemias, and more specifically AML, such as MLL-AF9 AML, in a subject, based on the assessment of the expression or activity of one or more of the genes listed in Tables 1 and 2 are disclosed. The use of antibodies or antigen-binding fragments thereof that bind to one or more of proteins showing preferential expression at the cell surface of AML leukemic cells for treating AML is also disclosed. | 2016-03-03 |
| 20160060710 | COMPAS-PCR METHOD AND METHODS FOR DETECTING, IDENTIFYING OR MONITORING SALMONID SPECIES - The present invention provides an asymmetric PCR method, the COMplementary-Primer-Asymmetric (COMPAS)-PCR, and specific methods for detecting, identifying or monitoring salmonid species. The present invention also encompasses oligonucleotide primers corresponding to species specific sequences. The use of the methods and primers are also an aspect of the present invention together with kits comprising said primers. | 2016-03-03 |
| 20160060711 | CruP Protects Against ROS in Oxygenic Photosynthetic Organisms - The herein invention provides methods for selecting a plant that is cold and anoxia tolerant by detecting the expression of CruP in said plant, selecting a plant that overexpresses CruP as being cold and anoxia tolerant. Also provided are methods for providing cold tolerance, anoxia tolerance and protection against reactive oxygen species in a plant by introducing a gene that encodes CruP with higher than wild type expression in said plant. | 2016-03-03 |
| 20160060712 | SYSTEMS AND METHODS FOR PERICARP GENOTYPING - The invention includes methods for obtaining samples of maternal tissue from seeds, obtaining genetic material from the maternal seed tissue, and performing a molecular analysis on the genetic material from the maternal seed tissue to determine maternal lineage of a single seed. The invention also includes methods for establishing a consensus maternal genotype from maternal seed tissues obtained from multiple seeds as well as methods for determining paternal lineage. | 2016-03-03 |
| 20160060713 | Systems and Methods for Genotyping Seed Components - The invention provides methods for obtaining genetic material from plant embryos while preserving their viability as well as methods for performing a molecular analysis of plant embryos, particularly with small quantities of genetic material. The methods may include the steps of collecting shed cellular material from one or more embryos; obtaining DNA from the shed cellular material; performing a molecular analysis of the DNA; and germinating at least one of said one or more embryos. A further extension of this method includes determining whether to germinate and grow the embryo or to discard the embryo based on its genotype as part of a breeding process. | 2016-03-03 |
| 20160060714 | SYSTEMS AND METHODS FOR GENOTYPING SEED COMPONENTS - The invention provides methods for obtaining genetic material from plant embryos while preserving their viability as well as methods for performing a molecular analysis of plant embryos, particularly with small quantities of genetic material. The methods may include the steps of collecting shed cellular material from one or more plant embryos; obtaining DNA from the shed cellular material; performing a molecular analysis of the DNA; and germinating at least one of said one or more plant embryos. A further extension of this method includes determining whether to germinate and grow the embryo or to discard the embryo based on its genotype as part of a breeding process. Also provided are methods of genotyping embryos using embryo shed cellular material contained in or on agar and methods of analyzing plant embryonic tissue derived from microspores. | 2016-03-03 |
| 20160060715 | SYSTEMS AND METHODS FOR GENOTYPING SEED COMPONENTS - The invention provides methods for obtaining genetic material from plant embryos while preserving their viability as well as methods for performing a molecular analysis of plant embryos, particularly with small quantities of genetic material. The methods may include the steps of collecting shed cellular material from one or more plant embryos; obtaining DNA from the shed cellular material; performing a molecular analysis of the DNA; and germinating at least one of said one or more plant embryos. A further extension of this method includes determining whether to germinate and grow the embryo or to discard the embryo based on its genotype as part of a breeding process. Also provided are methods of genotyping embryos using embryo shed cellular material contained in or on agar and methods of analyzing plant embryonic tissue derived from microspores. | 2016-03-03 |
| 20160060716 | GeXP Detection Kits for Identification of 11 Kinds of Duck Virus Diseases - Provided herein is a GeXP detection kit for identification of 11 kinds of duck virus diseases. The detection kit includes a primer set for identifying or auxiliarily identifying pathogens of duck communicable diseases, including one or more of primer pair A, primer pair B primer pair C, primer pair D, primer pair E, primer pair F, primer pair G, primer pair H, primer pair I, primer pair J, primer pair K and primer pair L. The can kit detect, simultaneously avian influenza virus, subtype H5, H7 and H9 of avian influenza virus, duck hepatitis virus, duck enteritis virus, duck Tembusu virus, Newcastle disease virus, egg drop syndrome virus, Muscovy duck reovirus, Muscovy duck parvovirus and duck circovirus with the primer set, PCR reagent or primer pairs provided in the present invention. | 2016-03-03 |
| 20160060717 | Amplification and Sequencing of Transrenal Nucleic Acids - The present invention provides highly sensitive methods used for diagnosing and monitoring various diseases and disorders by detecting and analyzing “ultra short” (20-50 base pair) nucleic acids obtained from bodily fluids. | 2016-03-03 |
| 20160060718 | EPSTEIN BARR VIRUS GENOTIPIC VARIANTS AND USES THEREOF AS RISK PREDICTORS, BIOMARKERS AND THERAPEUTIC TARGETS IN MULTIPLE SCLEROSIS - The present invention relates to a nucleic acid coding for a variant of the Epstein Barr nuclear antigen 2 (EBNA2) for use as a biomarker for predicting the risk of developing multiple sclerosis and/or for screening and/or for the diagnosis and/or prognosis of multiple sclerosis, and to an in vitro method for predicting the risk of developing and/or for screening for multiple sclerosis and/or for the diagnosis and/or prognosis of multiple sclerosis in a subject, comprising the detection of the presence of said nucleic acid. | 2016-03-03 |
| 20160060719 | PROCESS FOR PURIFYING BEET JUICE - The present invention relates to a process for purifying beet sugar juice and more particularly sugar juice obtained by pressing beets. It also relates to the purified juice and to the uses thereof, in particular as a fermentation substrate and for preparing granulated sugar. The purification process according to the invention comprises a step of passing the juice to be treated through a cellulose-fibre-based pre-layer. This process can be improved when the juice to be treated comprises between 0.1% and 4% of cellulose fibres. | 2016-03-03 |
| 20160060720 | STAINLESS STEEL AND METHOD OF MANUFACTURING THE SAME - A stainless steel that includes chromium and other alloying element as a plurality of alloying elements including: a base material layer including chromium of a specified chromium content necessary for forming a passive film or more; and a superficial layer including chromium at a lower chromium content than the chromium content contained in the base material layer, and the superficial layer including the other alloying elements at a same content of the other alloying element as the content of the other alloying element contained in the base material layer. | 2016-03-03 |
| 20160060721 | ABRASION RESISTANT STEEL PLATE HAVING EXCELLENT LOW-TEMPERATURE TOUGHNESS AND HYDROGEN EMBRITTLEMENT RESISTANCE AND METHOD FOR MANUFACTURING THE SAME - Abrasion resistant steel plates with excellent low-temperature toughness and hydrogen embrittlement resistance having a Brinell hardness of 401 or more, and methods for manufacturing such steel plates. The steel plates have a lath martensitic structure with an average grain size of not more than 20 μm, and the steel plates include fine precipitates that are 50 nm or less in diameter and that have a density of 50 or more particles per 100 μm | 2016-03-03 |
| 20160060722 | HOT-STAMPED STEEL, COLD-ROLLED STEEL SHEET AND METHOD FOR PRODUCING HOT-STAMPED STEEL - A hot-stamped steel according to the present invention has a predetermined chemical composition, satisfies (5×[Si]+[Mn])/[C]>10 when [C] is the amount of C by mass %, [Si] is the amount of Si by mass %, and [Mn] is the amount of Mn by mass %, includes 40% to 95% ferrite and 5% to 60% martensite in area fraction, and optionally further includes 10% or less pearlite in area fraction, 5% or less retained austenite in volume fraction, and less than 40% bainite in area fraction. The total of the area fraction of ferrite and the area fraction of martensite is 60% or more, the hardness of martensite measured with a nanoindenter satisfies H | 2016-03-03 |
| 20160060723 | HIGH STRENGTH HOT-ROLLED STEEL SHEET AND METHOD OF PRODUCING THE SAME - A high-strength hot-rolled steel sheet has a tensile strength TS of 980 MPa or more and is manufactured by controlling the steel sheet to have a chemical composition containing C: more than 0.1% and 0.2% or less, Si: 0.5% or more and 3.0% or less, Mn: 1.0% or more and 3.5% or less, P: 0.05% or less, S: 0.004% or less, Al: 0.10% or less, N: 0.008% or less, Ti: 0.05% or more and 0.15% or less, V: more than 0.10% and 0.30% or less, and the balance being Fe and inevitable impurities. Surface regions have a microstructure including mainly a ferrite phase, and an inner region has a microstructure including mainly a bainite phase. The proportions of the surface regions in the thickness direction of the steel sheet are 1.0% or more and 5.0% or less of the whole thickness respectively from the upper and lower surfaces of the steel sheet. | 2016-03-03 |
