| 09th week of 2011 patent applcation highlights part 56 |
| Patent application number | Title | Published |
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| 20110053173 | Game with detection capability - Methods and systems are described herein relating to game systems. In one aspect, a game system includes: at least one game component configured for use in a game system by an individual player; at least one sensor system operably connected to the at least one game component and configured to detect one or more analyte, the at least one sensor system including a signal transmitter; at least one signal detector configured to detect a signal transmitted from the at least one sensor system; and at least one principal game unit operably connected to the at least one signal detector, the at least one principal game unit including at least one signal transmitter configured to transmit a signal responsive to the at least one signal detector. | 2011-03-03 |
| 20110053174 | Magnetic-nanoparticle conjugates and methods of use - The present invention provides novel compositions of binding moiety-nanoparticle conjugates, aggregates of these conjugates, and novel methods of using these conjugates, and aggregates. The nanoparticles in these conjugates can be magnetic metal oxides, either monodisperse or polydisperse. Binding moieties can be, e.g., oligonucleotides, polypeptides, or polysaccharides. Oligonucleotide sequences are linked to either non-polymer surface functionalized metal oxides or with functionalized polymers associated with the metal oxides. The novel compositions can be used in assays for detecting target molecules, such as nucleic acids and proteins, in vitro or as magnetic resonance (MR) contrast agents to detect target molecules in living organisms. | 2011-03-03 |
| 20110053175 | Asymmetrically branched polymer conjugates and microarray assays - A composition comprising a conjugate of a randomly and asymmetrically branched dendritic polymer. | 2011-03-03 |
| 20110053176 | PARTICLE SUSPENSION AND REAGENT KIT FOR USE IN IMMUNOASSAY - A particle suspension for use in immunoassay, comprising: particles for use in immunoassay; and a silicone antifoam agent, is disclosed. And a reagent kit for use in immunoassay, comprising: a reagent containing particles and a silicone antifoam agent; another reagent containing an antigen or antibody capable of binding to a target substance and particles; and a further reagent containing a labeled antigen or antibody capable of binding to the target substance, is disclosed. | 2011-03-03 |
| 20110053177 | MASS SPECTROMETRIC METHODS AND PRODUCTS - The invention involves assays, diagnostics, kits, and assay components for mass spectrometry and other methods to determine levels of glycated CD59 in subjects. | 2011-03-03 |
| 20110053178 | Methods and Compositions for Detection of Lethal Cell and Uses Thereof - The present invention relates to methods and compositions for identifying and detecting lethal cell useful for monitoring disease status and therapy response in various types of cancer patients regardless of the etiological origin of the cancer and uses thereof. | 2011-03-03 |
| 20110053179 | Biomarkers For Prediction Of Major Adverse Cardiac Events And Uses Thereof - The present invention relates to combinations of biomarkers and levels thereof that may be used, for example, in the determination of risk associated with the occurrence of a major adverse cardiac event (MACE) in a patient. | 2011-03-03 |
| 20110053180 | KINASE SENSORS - The present invention generally relates to compositions and methods for determining kinase activity. In some cases, the compositions comprise a triazole heterocycle. In some embodiments, the compositions comprise a quinoline moiety. In one aspect, the present invention is directed to compositions that undergo chelation-enhanced fluorescence (CHEF). In some cases, the compositions may have fluorescence emission spectra with peak maxima greater than 490 nm. The compositions of the present invention can be used, in certain embodiments, to detect phosphorylated substrates and biological processes such as phosphorylation events. | 2011-03-03 |
| 20110053181 | METHOD FOR DETECTING OBJECTIVE SUBSTANCE AND KIT FOR DETECTING OBJECTIVE SUBSTANCE - A method for detecting an objective substance in a sample using a chromatographic test device having a detection region on which a capture substance capable of binding to the objective substance is immobilized, comprising: mixing the sample and an enzyme-labeled substance capable of binding to the objective substance; trapping the objective substance binding to the enzyme-labeled substance by the capture substance in the detection region, by adding the liquid mixture to the chromatographic test device; adding an anionic surfactant-containing reagent to the detection region in which the objective substance is captured; reacting a luminescent substrate with the enzyme of the enzyme-labeled substance binding to the capture substance through the objective substance in the detection region; and detecting the objective substance in the sample by detecting luminescence generated from the detection region by the reaction of the luminescent substrate with the enzyme. A kit is also disclosed. | 2011-03-03 |
| 20110053182 | DIAGNOSIS OF PRE-CANCEROUS CONDITIONS USING PCDGF AGENTS - The present invention relates to methods and compositions designed for the treatment or management of pre-cancerous conditions, especially in order to prevent, delay, or decrease the likelihood that the pre-cancerous condition will progress to malignant cancer. The methods of the invention comprise the administration of an effective amount of one or more agents that decrease/inhibit PCDGF expression, secretion, and/or activity. The invention also provides pharmaceutical compositions comprising one or more PCDGF agents. In some embodiments, the PCDGF agents can be administered with other therapeutic agents for treatment or management of a pre-cancerous condition that are not PCDGF-based. Diagnostic methods and methods for screening for therapeutically useful PCDGF agents are also provided. | 2011-03-03 |
| 20110053183 | METHOD OF CONCENTRATING HUMAN MESENCHYMAL STEM CELLS - The present invention is intended to provide methods for highly enriching human mesenchymal stem cells from a cell population containing the human mesenchymal stem cells. To highly enrich human mesenchymal stem cells, CD271 | 2011-03-03 |
| 20110053184 | Nucleic Acid Encoding A Haplotype of Human T2R Receptor hT2R50 - The present invention relates to the discovery of a novel haplotype of the human taste receptor hT2R50 in the T2R taste receptor family that responds to particular bitter ligands, i.e., 2-acetylpyrazine and ethylpyrazine. The present invention also relates to the use of this novel haplotype in assays for identifying ligands that modulate the activation of the hT250 taste receptor. These compounds potentially may be used as additives in foods, beverages and medicinals for modifying (blocking) hT2R50-associated bitter taste. | 2011-03-03 |
| 20110053185 | CULTURE BASED SCREENING ASSAY AND METHODS OF USE THEREOF TO IDENTIFY AGENTS WHICH MODULATE TUMOR DEVELOPMENT, INVASION AND DIFFERENTIATION - A 3D organotypic culture which phenocopies aggressive, invasive cancer and methods of use thereof are provided. | 2011-03-03 |
| 20110053186 | Chlorite in the Treatment of Neurodegenerative Disease - The invention features methods of treating a macrophage-associated neurodegenerative disease such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), or multiple sclerosis (MS) in a subject by administering chlorite in an amount effective to decrease blood immune cell activation. The invention also features methods of monitoring therapy by assessing blood immune cell activation before and after therapy. | 2011-03-03 |
| 20110053187 | SILICA-BASED MATERIAL FOR DETECTION AND ISOLATION OF CHITIN AND CHITIN-CONTAINING MICROORGANISMS - The subject invention provides silica-based material that has high affinity to chitin, chitin derivatives and chitin-containing microorganisms at an acidic pH. In an embodiment, the silica-based material surface comprises glass. Also provided are methods for preparing the subject silica-based chitin-binding material. In addition, the subject invention provides rapid, specific, sensitive, accurate and convenient methods for detection, isolation and purification of chitin, chitin derivatives and chitin-containing microorganisms. | 2011-03-03 |
| 20110053188 | ENDOTOXIN DETECTION METHOD - The invention relates to a method for detecting endotoxins in a sample. | 2011-03-03 |
| 20110053189 | Type IV secretion system proteins in sero-detection of Anaplasma phagocytophium - Disclosed are two (2) proteins in the Type IV Secretion System (TIVSS) in | 2011-03-03 |
| 20110053190 | Use of CFH or ApoH as a Biochemical Diagnostic Marker for Complete Remission in Acute Myeloid Leukemia - The present invention relates to a diagnostic method for acute myeloid leukemia, in particular, a method for using CFH or ApoH in patient sera as biochemical diagnostic markers to determine complete remission in acute myeloid leukemia. In accordance with this invention, CFH and ApoH are identified as a novel biochemical marker for understanding the biological mechanism and responsiveness to disease in AML patients after induction chemotherapy, and can be used as a biochemical marker for evaluating the prognosis of disease in patients after induction chemotherapy. | 2011-03-03 |
| 20110053191 | METHOD FOR RISK REDUCTION IN GLYCEMIC CONTROL - Disclosed is a method for identifying a subject being susceptible to a therapy for intensive glycemic control, the subject suffering from diabetes and being in need for a therapy for intensive glycemic control, based on determining the amount of PLGF (placental growth factor) in a sample of the subject and comparing the thus determined amount to a reference amount. In a preferred embodiment, the method further includes determining at least one further marker selected from the group consisting of a cardiac troponin and a natriuretic peptide and comparing the determined amount(s) to a reference amount (amounts). Moreover, disclosed is a method for predicting the risk of an acute cardiovascular event in a subject who suffers from diabetes and is on intensive glycemic control. Further disclosed is a kit and a device adapted to carry out the method of the present invention. | 2011-03-03 |
| 20110053192 | Method Of Rapid Detection Of An Analyte In Bodily Fluids Using A Fluorescent Dry Test Strip Biosensor - Disclosed herein is a dry fluorescence biosensor strip for rapid detection of a target analyte present in bodily fluids. The dry fluorescence biosensor strip comprises a sample receptacle and a dry detection membrane. The sample receptacle receives a sample of one of the bodily fluids. The dry detection membrane detects presence of the target analyte in the received sample based on fluorescence induced on the dry detection membrane. Fluorescent signals are emitted from the dry detection membrane on induction of fluorescence. A fluorometer quantifies measurable properties of the target analyte based on the emitted fluorescent signals. The dry fluorescence biosensor strip may further comprise a filtration membrane for filtering the received sample. The filtered sample migrates from the filtration membrane to the dry detection membrane. The dry detection membrane may then detect presence of the target analyte in the filtered sample. | 2011-03-03 |
| 20110053193 | Protein Assay - A method is described for the measurement of thrombin activity in the presence of fibrinogen, or for the measurement of the functionality of fibrinogen in the presence of thrombin. | 2011-03-03 |
| 20110053194 | TRANSFORMANT TRANSFECTED WITH FLAVIN ADENINE DINUCLEOTIDE-BINDING GLUCOSE DEHYDROGENASE GENE AND METHOD FOR PRODUCING FLAVIN ADENINE DINUCLEOTIDE-BINDING GLUCOSE DEHYDROGENASE USING THE SAME - It is intended to highly efficiently produce a large amount of novel FAD-GDH capable of more accurately measuring a glucose level. Provided is a transformant in which a DNA encoding a flavin adenine dinucleotide-binding glucose dehydrogenase selected from the group consisting of (a) a DNA encoding the amino acid sequence of SEQ ID NO: 20; (b) a DNA consisting of the base sequence of SEQ ID NO: 19; (c) a DNA having a base sequence homologous to the base sequence of SEQ ID NO: 19 and encoding a protein having a flavin adenine dinucleotide-binding glucose dehydrogenase activity; (d) a DNA encoding the amino acid sequence of SEQ ID NO: 34; (e) a DNA consisting of the base sequence of SEQ ID NO: 33; and (f) a DNA having a base sequence homologous to the base sequence of SEQ ID NO: 33 and encoding a protein having a flavin adenine dinucleotide-binding glucose dehydrogenase activity has been introduced. Further, a method for producing a flavin adenine dinucleotide-binding glucose dehydrogenase using the transformant is provided. | 2011-03-03 |
| 20110053195 | CATALYTICALLY INACTIVE PROTEINS AND METHOD FOR RECOVERY OF ENZYMES FROM PLANT-DERIVED MATERIALS - An inactive xylanase molecule for the recovery of xylanase activity in plant-derived material containing active xylanase enzyme(s) and xylanase inhibitors. The inactive xylanase molecule of binds to xylanase inhibitors in the plant-derived material, thereby allowing accurate measurement of xylanase enzyme activity of the enzyme contained in the plant-derived material. The invention further includes amino acid molecules depicted by SEQ ID NOS. 4 through 112, wherein the catalytically active sites of each of the amino acids have been modified resulting in inactive xylanase molecules. A method of production of the inactive xylanase molecules includes expression of the inactive xylanase molecule in microbial or eukaryal (e.g., yeast including | 2011-03-03 |
| 20110053196 | METHOD FOR MODIFYING A PEPTIDE AND A METHOD FOR IDENTIFYING A PEPTIDE - The present invention is to provide a method for easily and specifically modifying specific amino acid residue(s) constituting a peptide and to provide a methodology of improving the accuracy of identification of the peptide using a new information of the peptide obtained from the number of modified amino acid residue by said specific modification method as mentioned. The method for modifying a peptide according to the present invention is characterized: | 2011-03-03 |
| 20110053197 | UBIQUITIN PROTEASOME SYSTEM PROFILING AND THE USE THEREOF IN CLINICAL APPLICATIONS FOR CANCER DIAGNOSIS - Provided herein are methods for the diagnosis, prognosis, or management of neoplastic diseases, i.e. cancer, and other diseases using profiles of the ubiquitin-proteasome system determined from acellular body fluids or cell-containing samples. Further provided are methods of predicting response to therapy in certain populations of cancer patients. | 2011-03-03 |
| 20110053198 | UBIQUITIN PROTEASOME SYSTEM PROFILING AND THE USE THEREOF IN CLINICAL APPLICATIONS FOR PROLIFERATIVE HEMATOLOGICAL DISORDERS - Provided herein are methods for the diagnosis, prognosis, or management of proliferative hematological disorders and other diseases using profiles of the ubiquitin-proteasome system determined from acellular body fluids or cell-containing samples. Further provided are methods of predicting response to therapy in certain populations of leukemia patients. | 2011-03-03 |
| 20110053199 | UBIQUITIN PROTEASOME SYSTEM PROFILING AND THE USE THEREOF IN CLINICAL APPLICATIONS FOR CANCER DIAGNOSIS - Provided herein are methods for the diagnosis, prognosis, or management of neoplastic diseases, i.e. cancer, and other diseases using profiles of the ubiquitin-protcasome system determined from acellular body fluids or cell-containing samples. Further provided are methods of predicting response to therapy in certain populations of cancer patients. | 2011-03-03 |
| 20110053200 | Method for increasing light emission from a chemiluminescent reaction - Method for increasing the emission of light from a chemiluminescent reaction including luminol, a peroxidase enzyme, an oxidant and a mediator of electrons through the use of a hypernucleophilic acylation catalyst belonging to the class of 4-aminopyridines. It is also described the use in diagnostic assays of chemiluminescent substrates containing said catalysts. | 2011-03-03 |
| 20110053201 | METHOD OF CELL SEPARATION - A method for the cell separation from blood or from blood products, having the following steps:
| 2011-03-03 |
| 20110053202 | ANALYTICAL SYSTEM, ANALYTICAL METHOD AND FLOW-PATH STRUCTURE - An analytical system for performing centrifugal analysis on a working fluid with different components includes a uniform-dividing unit with a reduced cross section to divide the working fluid, a separating unit connected to the uniform-dividing unit, and a detecting unit. The detecting unit includes a detection compartment and a constant-quantity region connected to the separating unit through a separation channel. When rotating the uniform-dividing unit, the working fluid located at the uniform-dividing unit is transmitted to and separated by the separating unit, thereby causing one component of the working fluid to be separated from the other component and transmitted to the detection compartment through the constant-quantity region. With constant-quantity region, the detection compartment can be prevented from flushing by the excess of the separated component, and thus yield of product detection can be increased and different assays detection is carried out with a small sample volume at the same time. | 2011-03-03 |
| 20110053203 | COPOLYMER ASSAY - The present invention provides methods and compositions for evaluating one or more properties of an amino acid copolymer. | 2011-03-03 |
| 20110053204 | USE OF AN ADAPTIVE CHEMICALLY REACTIVE PLASMA FOR PRODUCTION OF MICROBIAL DERIVED MATERIALS - A relatively lower value carbonaceous feedstock can be converted into a relatively higher value chemical product, by introducing the relatively lower value carbonaceous feedstock into an inductively coupled plasma (ICP) torch under conditions selected to generate a synthetic gas mixture having a tailored composition, and then introducing the synthetic gas mixture into a microbial digester configured to convert the synthetic gas mixture into the product. Significantly, the composition of the synthetic gas mixture produced by the ICP torch can be quickly modified to correspond to an optimal quality and quantity required by the digester, such that if the quantity of composition of the synthetic gas mixture being provided does not meet the needs of the digester, the quantity and stoichiometric ratio can be quickly varied. This enables greater efficiency to be achieved as compared to systems where the quality and quantity of the synthetic gas mixture cannot be easily changed. | 2011-03-03 |
| 20110053205 | Composition and Methods for Expressing Reporter Molecules in Mammalian Cells - Disclosed herein is a novel system and methods for expressing exogenous genes, such as genes encoding fluorescent proteins, in mammalian cells. In one embodiment of this system and methods, a gene essential for viral infectivity or replication in cell culture is deleted or inactivated in the genome of a non-mammalian DNA virus. The exogenous gene operably linked to a mammalian promoter is then inserted into the non-replicative non-mammalian DNA virus. The non-replicative virus is propagated in a host cell that expresses in trans the deleted or inactivated gene or a functional homolog. | 2011-03-03 |
| 20110053206 | METHOD OF USING LIGAND-FREE LYSING AGENT IN HEMOGLOBIN ANALYSIS - Lysing agents that are free of ligands, including cyanide, for binding hemoglobin for hematology analyzers. The ligand-free lysing agents achieve accurate quantification of hemoglobin parameters, thereby replacing existing lysing agents for analysis of hemoglobin. | 2011-03-03 |
| 20110053207 | SYSTEM AND METHOD FOR IN VITRO BLOOD VESSEL MODELING - The present invention provides an in vitro blood vessel model for investigation of drug induced vascular injury and other vascular pathologies. The in vitro blood vessel model provides two channels separated by a porous membrane that is coated on one side by an endothelial cell layer and is coated on the other side by a smooth muscle cell layer, wherein said model is susceptible to the extravasation of red blood cells across said porous membrane due to drug induced vascular injury. | 2011-03-03 |
| 20110053208 | BIOLOGICAL SAMPLE IDENTIFICATION SYSTEM - The present invention contemplates a handling device for a biological specimen. The handling device includes a substrate with at least one crease that divides the substrate into a handle portion and a receiving portion that includes an aperture having a perimeter that is configured so that it receives a container having a cover that includes a biological specimen for testing, while resisting pull-through of the container relative to the substrate. | 2011-03-03 |
| 20110053209 | USE OF AN IMMUNOREGULATORY NK CELL POPULATION FOR MONITORING THE EFFICACY OF ANTI-IL-2R ANTIBODIES IN MULTIPLE SCLEROSIS PATIENTS - The use of CD56bright NK cell counts as a biomarker for the efficacy of anti-IL-2R antibody treatment in patients diagnosed with multiple sclerosis. | 2011-03-03 |
| 20110053210 | BLOOD ANALYZER, BLOOD ANALYSIS METHOD AND HEMOLYTIC AGENT - This blood analyzer includes a sample preparation portion preparing a measurement sample free from a labeling substance from a blood sample and a hemolytic agent free from a labeling substance, a light information generation portion generating fluorescent information and at least two types of scattered light information from the measurement sample and a control portion performing a first classification of white blood cells in the measurement sample into at least four groups of monocytes, neutrophils, eosinophils and others on the basis of the fluorescent information and the two types of scattered light information. | 2011-03-03 |
| 20110053211 | PROCESS AND DEVICE FOR DETERMINING THE CONDITION OF BIOLOGICAL MATERIAL, IN PARTICULAR FOOD - The invention relates to a process for determining—remotely and without taking samples—the condition of biological material, in particular food, as well as a device for performing this process. Radiation emission is thus induced with coherent beams in the material to be examined and is directly measured, whereby the measured values are compared to a nominal or boundary value. To this end, the device has a radiation source for emitting coherent beams, a detector for determining the induced radiation emission, and a control device, whereby the control device contains a microcomputer unit for comparison of the determined radiation emission with the nominal and boundary values that are stored in the memory. | 2011-03-03 |
| 20110053212 | BLOOD ANALYZER, BLOOD ANALYSIS METHOD, HEMOLYTIC AGENT AND STAINING AGENT - This blood analyzer includes a sample preparation portion preparing a first measurement sample containing a blood sample and a hemolytic agent and a second measurement sample containing the blood sample, the same hemolytic agent as the hemolytic agent and a staining agent and a control portion classifying white blood cells in the first measurement sample into at least four groups of monocytes, neutrophils, eosinophils and others on the basis of fluorescent information and two types of scattered light information generated by a light information generation portion and classifying blood cells in the second measurement sample into at least malaria-infected red blood cells and others on the basis of fluorescent information and scattered light information generated by the light information generation portion. | 2011-03-03 |
| 20110053213 | Polypeptides Having Ferulic Acid Esterase Activity and Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having ferulic acid esterase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 2011-03-03 |
| 20110053214 | PRODUCTION OF GALACTOSYLATED GLYCOPROTEINS IN LOWER EUKARYOTES - The present invention provides a novel lower eukaryotic host cell producing human-like glycoproteins characterized as having a terminal β-galactose residue and essentially lacking fucose and sialic acid residues. The present invention also provides a method for catalyzing the transfer of a galactose residue from UDP-galactose onto an acceptor substrate in a recombinant lower eukaryotic host cell, which can be used as a therapeutic glycoprotein. | 2011-03-03 |
| 20110053215 | Endoglycosidases that Cleave O-linked Glycans - Methods and compositions have been described that relate to a newly identified polypeptide family wherein each member has O-glycosidase activity and specified sequence characteristics. This family of enzymes can be used for example for cleaving O-linked glycans and for synthesis of neoglycopeptides or neoglycoproteins. | 2011-03-03 |
| 20110053216 | Modified Cyanobacteria - Disclosed is a modified photoautotrophic bacterium comprising genes of interest that are modified in terms of their expression and/or coding region sequence, wherein modification of the genes of interest increases production of a desired product in the bacterium relative to the amount of the desired product production in a photoautotrophic bacterium that is not modified with respect to the genes of interest. | 2011-03-03 |
| 20110053217 | Polynucleotides encoding signal peptide-containing molecules - The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP. | 2011-03-03 |
| 20110053218 | MULTIPLE PROMOTER PLATFORM FOR PROTEIN PRODUCTION - A multiple promoter platform for expression of a protein or multiple and different proteins in a microorganism comprising two or more expression vectors having a nucleic acid molecule encoding a protein to be expressed, or having different nucleic acid molecules encoding different proteins to be expressed, wherein each vector has a different promoter operably linked to the nucleic acid molecule, and uses of the multiple promoter platform to produce recombinant proteins. | 2011-03-03 |
| 20110053219 | Method for the Targeted Integration of Multiple Copies of a Gene of Interest in a Yarrowia Strain - This invention concerns a method for the targeted integration of at least three copies of a gene of interest in the genome of a | 2011-03-03 |
| 20110053220 | NOVEL PROTEIN CAPABLE OF BINDING TO HYALURONIC ACID, AND METHOD FOR MEASUREMENT OF HYALURONIC ACID USING THE SAME - The present invention relates to a polynucleotide encoding a protein comprising an amino acid sequence shown in SEQ ID NO: 2, wherein the protein encoded by the polynucleotide has a hyaluronic acid binding ability, the protein, a method for measuring hyaluronic acid using the protein, and a reagent kit for measuring hyaluronic acid comprising the protein as a constituent. | 2011-03-03 |
| 20110053221 | RECOMBINANT PRODUCTION OF AUTHENTIC HUMAN PROTEINS USING HUMAN CELL EXPRESSION SYSTEMS - The present invention relates to novel expression cassettes and vectors for efficiently producing authentic recombinant human proteins from stable cultures of novel human cell lines, the authentic recombinant proteins produced therefrom, and antibodies raised against those authentic recombinant proteins. | 2011-03-03 |
| 20110053222 | PC5 as a Factor IX Propeptide Processing Enzyme - Compositions and methods for preparing Factor IX, Factor IX-containing fusion proteins, and Factor IX-containing conjugates with processing of Factor IX propeptide by PCS, are provided. In one embodiment PCS is used to process a precursor polypeptide for a Factor IX-Fc monomer-dimer hybrid. | 2011-03-03 |
| 20110053223 | CELL CULTURE METHODS TO MAKE ANTIBODIES WITH ENHANCED ADCC FUNCTION - The present invention concerns antibodies with enhanced antibody-dependent cell mediated cytotoxicity (ADCC) and method for preparation thereof. | 2011-03-03 |
| 20110053224 | NOVEL COMPOSITION OF MATTER AND METHOD FOR STIMULATING THE GROWTH OF BENEFICIAL MICROORGANISMS - The invention describes a novel composition of matter obtained from the leaves of green plants, which is useful in promoting the growth of beneficial microorganisms. Specifically, that the invention describes a hydrolysate prepared from plant leaf biomass (leaf biomass hydrolysate or ‘LBH’) which dramatically stimulates the growth of beneficial microorganisms. Use of LBH as a fermentation substrate can also stimulate rapid production of organic acids and other organic compounds. LBH can be used as a substrate to promote the fermentation-based production of biobased industrial chemicals or biofuels, LBH can be utilized as a prebiotic to promote the growth of beneficial probiotic organisms, hi addition, LBH may also be useful in stimulating the fermentation-based production of other products, examples of which include preservatives, antibiotics, antigens, vaccines, amino acids, vitamins, recombinant proteins, bioremediation treatments, and immobilized enzymes. | 2011-03-03 |
| 20110053225 | MULTIFUNCTIONAL TAGS - The present invention relates to multifunctional protein production tags comprising at least 4, preferably 4-8 amino acids, for optimising expression of proteins and purification thereof by various multi-step processes including chromatographic or filtration, as well as batch unit operations. The tags include sequences of multiple defined purposes which are not generated in defined linear sequence regions related to one purpose but as integrated sequences often overlapping each other, i.e. the defined purposes are not discrete separate units on the tag but rather heterogeneously distributed in the tag. The invention also relates to an expression vector encoding the multipurpose tag and a method for protein purification, comprising expressing a protein in the expression vector and purifying the protein in several steps using functionalities of the multipurpose tag. | 2011-03-03 |
| 20110053226 | METHOD FOR ENZYMATIC SYNTHESIS OF CHEMICALLY MODIFIED RNA - The present invention relates to a method for enzymatically synthesizing chemically modified RNA by using RNA-dependent RNA polymerases (RdRp), especially RdRps from viruses of the Caliciviridae family. The method of the present invention is particularly useful for preparing RNA molecules of increased stability especially with respect to RNA degradation, for example for in vivo applications. Further subject matter of the present invention relates to a kit for carrying out the enzymatic synthesis of the chemically modified RNA. | 2011-03-03 |
| 20110053227 | PROCESS FOR PREPARING L-AMINO ACIDS USING IMPROVED STRAINS OF THE ENTEROBACTERIACEAE FAMILY - The invention relates to a process for preparing L-amino acids by fermenting recombinant microorganisms of the Enterobacteriaceae family, characterized in that
| 2011-03-03 |
| 20110053228 | MICROBIAL PROCESSING OF CELLULOSIC FEEDSTOCKS FOR FUEL - A system and method are provided which utilize microbes to convert biomass feedstock into a fuel. In one aspect, a method of producing aromatic compounds and lipids includes: receiving a feedstock including biological matter; separating the feedstock into a liquid phase feedstock and a solid phase feedstock; adding water and nutrients to the solid phase feedstock, thereby producing a liquid culture; inoculating the liquid culture with microbes capable of converting the solid phase feedstock into aromatic compounds and lipids, the inoculated liquid culture yielding microbial biomass; providing suitable conditions for the microbes to convert the solid phase feedstock to aromatic compounds and lipids; and extracting produced aromatic compounds and lipids. | 2011-03-03 |
| 20110053229 | METHOD FOR PRODUCTION OF IMMOBILIZED ENZYME - Provided is a method of producing an immobilized lipolytic enzyme which has almost the same ability as that of an unused immobilized enzyme by effectively utilizing an immobilization carrier in a used immobilized enzyme which has been used in an esterification reaction. | 2011-03-03 |
| 20110053230 | METHOD FOR CONTROLLING RATE OF LOWERING MOLECULAR WEIGHT OF POLYSACCHARIDES CONTAINED IN CELLULOSIC BIOMASS, AND METHOD FOR PRODUCING SUGAR, ALCOHOL, OR ORGANIC ACID - An object of the present invention is to provide, with regard to a method for lowering the molecular weight of polysaccharides contained in a cellulosic biomass by mixing the cellulosic biomass with ionic liquid, a method for controlling such rate of lowering of molecular weight. Also, a method for producing sugar, alcohol, or organic acid using the controlling method is provided. The method comprises mixing a cellulosic biomass with ionic liquid under an atmosphere with a partial pressure ratio differing from that of air. Under such an atmosphere with oxygen partial pressure higher than that of air, the rate of lowering molecular weight can be increased, and under an atmosphere with nitrogen partial pressure or carbon dioxide partial pressure higher than that of air or a reduced-pressure atmosphere, the rate of lowering molecular weight can be decreased. | 2011-03-03 |
| 20110053231 | METHOD OF PRODUCING LACTIC ACID BY CONTINUOUS FERMENTATION - A method of producing lactic acid continuous fermentation including filtering a culture of polyploid yeast having a capacity to produce lactic acid through a porous membrane having an average pore size of not less than 0.01 μm and less than 1 μm, and recovering the product from the filtrate while the unfiltered liquid is retained in or returned to the culture and a fermentation feedstock is added to the culture. | 2011-03-03 |
| 20110053232 | Producing Itaconic Acid in Yeast Using Glycerol as the Substrate - Method for producing itaconic acid in yeast cells using glycerol as the substrate. The yeast cells express cis-aconitic acid decarboxylase and optionally, citrate synthase and/or aconitase at high levels. | 2011-03-03 |
| 20110053233 | Methods for improving malic acid production in filamentous fungi - The present invention relates to methods of producing a C4 dicarboxylic acid, comprising: (a) cultivating a filamentous fungal host cell comprising a polynucleotide selected from the group consisting of a heterologous first polynucleotide encoding a C4 dicarboxylic acid transporter, a heterologous second polynucleotide encoding a malate dehydrogenase, and a heterologous third polynucleotide encoding a pyruvate carboxylase; wherein the filamentous fungal host cell is capable of secreting increased levels of the C4 dicarboxylic acid compared to the filamentous fungal host cell without the heterologous polynucleotide when cultivated under the same conditions; and (b) recovering the C4 dicarboxylic acid. The present invention also relates to methods for increasing C4 dicarboxylic acid production, filamentous fungal host cells and malate dehydrogenase variants. | 2011-03-03 |
| 20110053234 | PRODUCTION METHOD FOR BIOMASS ALCOHOL - The production method for biomass-alcohol comprises saccharification step to saccharify biomass, first concentrating step including to atomize for ultrasonically vibrating the saccharified solution and atomizing the saccharified solution into mist, and to elevate the sugar concentration in the saccharified solution by removing water from the saccharified solution, fermentation step for fermenting the saccharified solution concentrated at the first concentrating step, and second concentrating step for separating alcohol from the alcohol water solution fermented at the fermentation step. | 2011-03-03 |
| 20110053235 | FERMENTATIVE PRODUCTION OF ISOBUTANOL WITH YEAST - The invention relates to a yeast cell producing isobutanol, characterized in that the cell has an increased metabolic flow of material from pyruvate and acetolactate, 2,3-dihydroxy isovalerate, 2-ketoisovalerate, isobutyraldehyde to isobutanol, in that at least one of the genes coding the enzymes, which are involved in this conversion, is over-expressed, and without any of said genes being heterologous to said yeast cell, and to a method for the production of isobutanol using yeast cells, comprising the provision of the yeast cells according to the invention, and bringing the yeast cell into contact with a fermentable carbon source. | 2011-03-03 |
| 20110053236 | ETHANOL PRODUCTION - A method for increasing production of ethanol in an ethanologenic cell using an autoinducer molecule, for example AI-2. | 2011-03-03 |
| 20110053237 | Producing Fermentation Products in the Presence of Aldehyde Dehydrogenase - The invention relates to a process of fermenting plant material in a fermentation medium into a fermentation product using a fermenting organism, wherein one or more aldehyde dehydrogenases are present in the fermentation medium. | 2011-03-03 |
| 20110053238 | METHOD OF PRODUCTION OF ETHANOL FROM TWO DIFFERENT STARTING MATERIALS - The present invention provides a method of improving the ethanol yield in production of an ethanol-containing product from a lignocellulosic biomass and a sugar product containing fermentable sugars derived from a sugar-rich material. The method comprises treatment, involving hydrolysis, of said lignocellulosic biomass in one or more steps to obtain lignocellulose-derived treatment products including fermentable sugars; and fermentation, using a fermenting agent, of a mixture comprising at least part of said lignocellulose-derived treatment products and said fermentable sugars derived from said sugar-rich material to obtain the ethanol-containing product, wherein an amount of said sugar product is mixed with an amount of at least one of the following: (i) lignocellulose-derived material in the treatment; (ii) lignocellulose-derived treatment products from the treatment; and (iii) lignocellulose-derived treatment products in the fermentation, such that said fermentable sugars derived from said sugar-rich material and said at least part of said lignocellulose-derived treatment products are present in the mixture, and said amounts are controlled such that the fermenting agent is subjected to stress by lignocellulose-derived treatment products to the extent that the ethanol yield is improved. Further, a corresponding method using a starch-rich starting material is provided as well as a corresponding use, composition and system. | 2011-03-03 |
| 20110053239 | METHODS - A method of pre-treating lignocellulosic and cellulosic biomass for utilization of carbohydrate or lignin from the biomass, the method comprising the steps of inoculating the lignocellulosic biomass with lignocellulose degrading brown rot fungus and incubating the inoculated biomass under conditions in which growth of the lignocellulose degrading brown rot is promoted. The incubation may be under conditions in which growth of the lignocellulose degrading brown rot is promoted is terminated after less than 50 days or before substantial depletion of glucose in the biomass occurs. | 2011-03-03 |
| 20110053240 | DNA DAMAGING AGENTS IN COMBINATION WITH TYROSINE KINASE INHIBITORS - The present invention relates to the signalling pathways connecting DNA damage, such as that induced by ionizing radiation or alkylating agents, and phosphorylation by tyrosine kinases. | 2011-03-03 |
| 20110053241 | DEVICE AND METHOD FOR MECHANICALLY DEFORMING CELLS - The present invention relates to a device for mechanically deforming cells comprising: a cell holding element ( | 2011-03-03 |
| 20110053242 | Immunoaffinity isolation of modified peptides from complex mixtures - The invention provides methods for isolating a modified peptide from a complex mixture of peptides, the method comprising the steps of: (a) obtaining a proteinaceous preparation from an organism, wherein the preparation comprises modified peptides from two or more different proteins; (b) contacting the preparation with at least one immobilized modification-specific antibody; and (c) isolating at least one modified peptide specifically bound by the immobilized modification-specific antibody in step (b). The method may further comprise the step of (d) characterizing the modified peptide isolated in step (c) by mass spectrometry (MS), tandem mass spectrometry (MS-MS), and/or MS | 2011-03-03 |
| 20110053243 | Asymmetrically branched polymer conjugates and microarray assays - A conjugate of a randomly and asymmetrically branched dendritic polymer and a member of a binding pair. | 2011-03-03 |
| 20110053244 | NOVEL PROTEIN DELIVERY SYSTEM TO GENERATE INDUCED PLURIPOTENT STEM (iPS) CELLS OR TISSUE-SPECIFIC CELLS - A novel protein delivery system to generate induced pluripotent stem (iPS) cells is described. The delivery system comprises a construct with a receptor binding domain that recognizes a receptor in a somatic cell, a translocation domain that allows the transfer of an inducer into the cytosolic space, and a cargo bearing domain to which the inducer is attached and facilitates transfer of the inducer into the cell. | 2011-03-03 |
| 20110053245 | ISOMERASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM - This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having isomerase activity, e.g., racemase activity, e.g., amino acid racemase activity, alanine racemase activity, and/or epimerase activity, and/or catalyze the re-, arrangement of atoms within a molecule, catalyze the conversion of one isomer into another, catalyze the conversion of an optically active substrate into a raceme, which is optically inactive, catalyze the interconversion of substrate enantiomers, catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of asymmetry, catalyze the stereochemical inversion of the configuration around an asymmetric carbon atom in a substrate having more than one asymmetric center, and/or catalyze the racemization of amino acids. Thus, the invention provides enzymes, compositions, methods for production of pharmaceutical compositions, pharmaceutical intermerdiates, antibiotics, sweeteners, peptide enzymes, peptide hormones, fuel and fuel additive compositions, foods and food additives, beverage and beverage additives, feeds and feed additives, drugs and drug additives, dietary supplements, textiles, wood, paper, pulp, and detergents comprising the polypeptides or polynucleotides in accordance with the invention. | 2011-03-03 |
| 20110053246 | OVEREXPRESSION OF PHYTASE GENES IN YEAST SYSTEMS - The present invention relates to a method of producing a heterologous protein or polypeptide having phytase activity in a yeast system. The invention also provides proteins having phytase activity which have increased thermostability. Yeast strains which produce a heterologous phytase and the vectors used to produce the phytase are also provided. | 2011-03-03 |
| 20110053247 | LARGE-SCALE PRODUCTION OF SOLUBLE HYALURONIDASE - Provided are methods for preparing large-scale preparations of soluble hyaluronidases. The methods employ cells that contain a plurality of active copies of nucleic acid encoding the soluble hyaluronidase and a plurality of feedings and temperature changes, whereby the encoded soluble hyaluronidase is secreted into the cell culture medium. | 2011-03-03 |
| 20110053248 | Serum-Free Virus Propagation Platform For A Virus Vaccine Candidate - The invention relates to methods for propagating viruses. In particular, the invention provides optimized conditions for propagating viruses. Optimization of the following parameters are provided: lipid concentrates as supplements to the medium, temperature shift from pre-infection to post-infection, multiplicity of infection, direct bead-to-bead transfer and serum supplementation of pre-infection medium. In particular, the invention provides for the first time a method for propagating a virus by culturing cells that are infected with the virus in a medium comprising chemically defined lipid concentrate (CDLC). In another claim, the CDLC is added to medium that is substantially free of serum for culture of virus-infected cells. | 2011-03-03 |
| 20110053249 | Adenoviruses Mutated In The VA Genes For Cancer Treatment - This invention refers to the use of an adenovirus for cancer treatment, being this adenovirus defective in its virus-associated (VA) RNAs. Said adenovirus has a mutation in the VAI or VAII gene sequence or both. This adenovirus may also have mutations in the sequences controlling expression of the VA RNAs. | 2011-03-03 |
| 20110053250 | ENRICHMENT METHOD OF VIRUS - The present invention provides a novel method that can increase readily a virus or viral vector concentration in a solution having a low concentration and a kit for performing the method. Conventional methods require complicated operations, expensive equipment, or highly trained experts for efficiently concentrating viruses from low-concentration virus solutions. The method of the present invention can concentrate viral vectors readily while maintaining infection abilities of the viral vectors, and thus it can be used as a safe and simple technique for concentrating a vector useful in the field of a genetic therapy or a vaccine therapy using a viral vector. | 2011-03-03 |
| 20110053251 | REAGENTS FOR LYSIS OF BACTERIAL CELLS - The invention provides a composition containing an aqueous liquid phase, bacterial cells, and an ionic compound dissolved in the liquid phase. The ionic compound is selected from the group consisting of 1-butyl-3-methyl-imidazolium-thiocyanate, 1-butyl-3-methyl-imidazolium-2(2-methoxy-ethoxy)ethylsulfate, 1-methyl-1-[4-(3-methyl-3H-imidazol-1-ium)-but-1-yl]-3H-imidazolium-di(toluylsulfate), and 1-butyl-3-methyl-imidazolium-octylsulfate. The compositions of the invention are advantageously used for preparing lysates of biological cells, particularly bacterial cells. | 2011-03-03 |
| 20110053252 | MICROORGANISM PRODUCING O-ACETYL-HOMOSERINE AND THE METHOD OF PRODUCING O-ACETYL-HOMOSERINE USING THE MICROORGANISM - Disclosed herein are a microorganism strain capable of producing the L-methionine precursor O-acetyl homoserine in high yield and a method of producing O-acetyl homoserine using the same. The microorganism strain is a strain of | 2011-03-03 |
| 20110053253 | MICROORGANISM PRODUCING O-ACETYL-HOMOSERINE AND THE METHOD OF PRODUCING O-ACETYL-HOMOSERINE USING THE MICROORGANISM - Disclosed is a strain of | 2011-03-03 |
| 20110053254 | MATERIALS AND METHODS RELATING TO MODIFYING THE BINDING OF ANTIBODIES - The invention relates to materials and methods for modifying the binding of antibodies, and more particularly to antibodies that are obtainable by inserting an amino acid sequence capable of binding to a target into a complementarity determining region of a parent antibody so that the antibody thus obtained is capable of binding to the target. The invention further relates to the uses of the antibodies for therapy, diagnosis or imaging, and to methods of producing the antibodies. | 2011-03-03 |
| 20110053255 | DEACTIVATING AN EXPLOSIVE COMPOSITION USING PLANTS - A method of deactivating an explosive composition provided in an explosive cartridge, which method comprises exposing the explosive composition to a deactivating agent that renders the explosive composition insensitive to detonation, wherein the deactivating agent is a plant. | 2011-03-03 |
| 20110053256 | Apparatus and method for maintaining and/or restoring viability of organs - An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program. | 2011-03-03 |
| 20110053257 | Photo-bioreactor with Particle Separation and Water Recovery System - The Photo-bioreactor with Particle Concentration and Water Recovery System is a bioreactor system designed to propagate algae under fully closed, controlled conditions. The system is highly efficient and has a reduced turnaround time compared to similar photo-bioreactors. The system has an integrated, gravity-flow biomass harvest and water recovery system that allows the operator to simultaneously harvest the cell concentrate and recycle the water used in the growth media. The bioreactor's scale can range from a single bench-top unit to multiple, large-scale commercial units in a manifold type array, and can utilize sunlight or artificial light. | 2011-03-03 |
| 20110053258 | Novel promoter sequence and the application thereof - The present invention provides a novel promoter sequence derived from a promoter of geminivirus, a eukaryotic virus, and has the characteristics of prokaryotic promoters. The isolated sequence includes SEQ ID NO: 5, which can drive the expression of foreign genes in prokaryotic cells to a high level utilizing the prokaryotic RNA polymerases. The present invention is a constitutive promoter which does not require the addition of external inducers to promote high-level gene expressions. The promoter activity of the present invention is 15-fold higher than the Rep gene promoter of geminivirus, which is also active in prokaryotic cells. Compared to the promoter activity of the standard constitutive prokaryotic promoter rrnB P1, the activity of the present invention is 11.1% higher. The activity of the present invention is additive when concatenated in the same polarity in the constructs, further enhancing the expression level of genes. | 2011-03-03 |
| 20110053259 | RECOMBINANT POXVIRUS EXPRESSING HOMOLOGOUS GENES INSERTED INTO THE POXVIRUS GENOME - The present invention relates to a recombinant poxvirus vector capable of expressing two or more homologous, foreign sequences, which derive from different variants of a microorganism, and which have a homology of 50% or above. The invention further relates to a method for preparing such recombinant poxvirus and the use of such recombinant poxvirus as medicament or vaccine. Additionally, a method for affecting preferably inducing, an immune response in a living animal, including a human, is provided. | 2011-03-03 |
| 20110053260 | RECOMBINANT POXVIRUS EXPRESSING HOMOLOGOUS GENES INSERTED INTO THE POXVIRAL GENOME - The present invention relates to a recombinant poxvirus vector capable of expressing two or more homologous, foreign sequences, which derive from different variants of a microorganism, and which have a homology of 50% or above. The invention further relates to a method for preparing such recombinant poxvirus and the use of such recombinant poxvirus as medicament or vaccine. Additionally, a method for affecting preferably inducing, an immune response in a living animal, including a human, is provided. | 2011-03-03 |
| 20110053261 | METHODS FOR DETERMINING CORRELATED RESIDUES IN A PROTEIN OR OTHER BIOPOLYMER USING MOLECULAR DYNAMICS - The invention provides methods and systems of determining biopolymer profiles and correlations between structural units (residues) of a biopolymer based on sampling of the conformational space available to the molecule. The correlations between these structural units can further be used to find networks within a biopolymer such as the coupled residue networks in a protein. The invention also provides for designing and engineering biopolymers including polypeptides, nucleic acids and carbohydrates using the information derived from the conformation clustering and subsequent methods described herein. | 2011-03-03 |
| 20110053262 | METHODS OF FABRICATING ENHANCED TISSUE-ENGINEERED CARTILAGE - Compositions and methods for fabricating a tissue-engineered cartilage construct comprising: providing a cell sample comprising a plurality of chondrocytes; culturing the cell sample to produce a tissue-engineered cartilage construct; and treating the tissue-engineered cartilage construct, wherein treating the tissue-engineered cartilage construct comprises the use of a biochemical reagent, a mechanical force, hydrostatic pressure, or any combination thereof. | 2011-03-03 |
| 20110053263 | Multipotent Cancer Stem Cell Lines and Method for Producing the Same - Provided is a multipotent cancer stem cell line derived from breast-cancer tissue and expressing a breast cancer stem cell marker. Also provided is a method for producing a multipotent cancer stem cell line, including (1) isolation of breast-cancer cells from previously extracted breast cancer tissue, (2) primary culture of the isolated breast cancer cells in a suspended state in a medium for suspension culture, (3) recovery of the cells in the suspended state from the primary culture, and (4) production of a multipotent cancer stem cell line by subculturing the recovered cells a predetermined number of times or more in a suspended state in the medium for suspension culture. | 2011-03-03 |
| 20110053264 | FRAMEWORK RESIDUE SUBSTITUTED HUMANIZED COL-1 ANTIBODIES AND THEIR USE - The present disclosure provides humanized COL-1 monoclonal antibodies that retain CEA binding affinity, compared to a parent antibody. Also disclosed herein are humanized COL-1 monoclonal antibodies that have reduced immunogenicity, compared to a parent antibody. The disclosed humanized COL-1 antibodies include substitution of framework residues with residues from the corresponding positions of a homologous human sequence. In several embodiments, methods are disclosed for the use of a humanized COL-1 antibody in the detection or treatment of a CEA-expressing tumor or cell in a subject. Also disclosed is a kit including the humanized COL-1 antibodies described herein. | 2011-03-03 |
| 20110053265 | Cell Culture Performance with Betaine - This invention relates generally to the field of cell culture. More particularly, the invention relates to improving viability of recombinant cell cultures and the yields of secreted polypeptides therefrom by the addition of betaine to the tissue culture medium. | 2011-03-03 |
| 20110053266 | Methods, kits, and compositions for stem cell self-renewal - The present invention relates to methods and kits for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods, kits, and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population. | 2011-03-03 |
| 20110053267 | METHOD FOR PREPARATION OF PLATELET FROM iPS CELL - It is an object of the present invention to provide a method for efficiently preparing blood cells, such as mature megakaryocytes and platelets, from iPS cells in an in vitro culture system. | 2011-03-03 |
| 20110053268 | METHOD FOR DIAGNOSIS OF ABNORMAL IRON METABOLISM USING ACTIVE HEPCIDIN AS INDICATOR - The present inventor employed surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) to analyze distinctive serum proteomic patterns of hemodialysis patients. The present inventor found three peptides at 2,192, 2,789, and 2,851 m/z that showed a significant correlation with the levels of serum ferritin. The molecular sizes of the 2,192 and 2,789 m/z matched well with the reported sizes of hepcidin-20 and -25, respectively, and the latter completely coincided with the size of synthetic hepcidin-25. It would be possible to diagnose abnormal iron metabolism by detecting bioactive forms of hepcidin in the serum. | 2011-03-03 |
| 20110053269 | LAMINAR CONSTRUCT FOR TISSUE-ENGINEERED DERMAL EQUIVALENT - Compositions and methods for creating a laminar construct for tissue-engineered dermal equivalent are provided. One composition provided herein comprises a hydrogel matrix comprising two or more hydrogels layers and a population of stem cells. Associated methods are also provided. | 2011-03-03 |
| 20110053270 | Patterning Hydrogels - A method for forming a pattern-coated substrate includes disposing a composition comprising a polysaccharide-based polymer on a substrate to generate a coated substrate. The polysaccharide-based polymer composition is substantially free of cross-linking monomers. The method further includes exposing a portion of the coated substrate to a first dose of UV radiation to induce crosslinking of the polysaccharide-based polymer, wherein a portion of the substrate is shielded from the ionizing radiation. The UV exposed coated substrate may be washed or hydrated to remove uncross-linked polysaccharide-based polymer. | 2011-03-03 |
| 20110053271 | IRRADIATION INDUCED GRAFTING OF POLYSACCHARIDES TO CELL CULTURE VESSELS - A method for grafting a polysaccharide to a surface of a cell culture article includes (a) contacting the surface of the article with the polysaccharide in a dry form; and (b) exposing the surface of the article and contacted dry polysaccharide to ionizing radiation to graft the polysaccharide to the surface of the article. In addition to grafting the polysaccharide to the surface, the ionizing radiation may serve to sterilize the article. | 2011-03-03 |
| 20110053272 | METHODS FOR CLONING AND MANIPULATING GENOMES - Compositions and methods are disclosed herein for cloning a donor genome in a heterologous host cell. In one embodiment, the donor genome can be further modified within a host cell. Modified or unmodified genomes can be further isolated from the host cell and transferred to a recipient cell. Methods disclosed herein can be used to alter donor genomes from intractable donor cells in more tractable host cells. | 2011-03-03 |
