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09th week of 2011 patent applcation highlights part 51
Patent application numberTitlePublished
20110052672TREATMENTS OF DISEASE OR DISORDERS USING NANOPARTICLES FOR FOCUSED HYPERTHERMIA TO INCREASE THERAPY EFFICACY - Methods are provided for the treatment of diseases and disorders using systematically-introduced nanoparticles to create a focused localized hyperthermia in a target area to enhance the effect of additional treatment therapies such as ionizing radiation. Advantages include an enhancement of the therapeutic effect of other therapies by increasing perfusion or reducing hypoxia in the treatment area, further, the methods herein may also result in the disruption of the vasculature, which provide further impetus for such treatments, singly and in combination with conventional therapies such as chemotherapy and radiation therapy. Methods for treating a target area may comprise systemically introducing nanoparticles into an organism; allowing the nanoparticles to preferentially accumulate in the target area, applying an external energy where the nanoparticles are adapted to transduce at least a portion of the external energy into a heal energy so as to create a focused localized hyperthermia; and applying a subsequent additional therapy.2011-03-03
20110052673THERAPEUTIC COMPOSITIONS - Therapeutic compositions containing therapeutic agents and nitrogen-containing lipids are described. These tertiary amine-containing polymers are preferably biodegradable and biocompatible. Nanoparticles, microparticles, and complexes containing lipid/therapeutic agent complexes are also described.2011-03-03
20110052674ANGIOTENSIN II RECEPTOR BLOCKER DERIVATIVES - New angiotensin II receptor blocker nitroderivatives of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereof: and their use for treating cardiovascular, renal and chronic liver diseases, inflammatory processes and metabolic syndromes.2011-03-03
20110052675Orally Disintegrting Forms for Sustained Release and Controlled Release - Orally disintegrating forms with sustained release capability and a method of making thereof are provided.2011-03-03
20110052676Composition For Delaying Cellular Senescence - Disclosed herein is a composition for delaying cellular senescence comprising from about 0.01 wt % to about 5 wt % of Hexapeptide-11(Phe-Val-Ala-Pro-Phe-Pro), based on the total weight of the composition, and a dermatologically-acceptable carrier for the peptide selected from the group consisting of water, oil, alcohol, silicone, and combinations thereof.2011-03-03
20110052677MODULATION OF SRPX2-MEDIATED ANGIOGENESIS - The present invention relates to nucleic acids and antibodies against SRPX2 and SRPX2 protein function in angiogenesis. Angiogenesis-related conditions, such as cancer or wound healing, can be treated by the composition comprising the SRPX2 antagonists or agonists, respectively.2011-03-03
20110052678METHOD FOR TREATING AGE RELATED MACULAR DEGENERATION - A method for treating age related macular degeneration uses insulin preparation applied topically in a therapeutically effective amount to an affected conjunctival sac of the eye. The topically effective dose is delivered to the fovea centralis and macula lutea. In other embodiments, additional therapeutic, pharmaceutical, biochemical, nutriceutical, biological (monoclonal antibodies and others) agent or compound, and organic and inorganic agents are also applied to the afflicted site through the conjunctival sac and choroidal vascular system of the eye. IGF-1 may be applied as well with or without insulin to treat ARMD.2011-03-03
20110052679SOLID NAPROXEN CONCENTRATES AND RELATED DOSAGE FORMS - The invention provides a composition consisting essentially of a solid naproxen concentrate, wherein the solid naproxen concentrate comprises (a) a solid naproxen free acid and (b) a solid naproxen alkali salt, and wherein at least 90% of the weight of the solid naproxen concentrate is naproxen free acid and naproxen alkali salt, as well methods of producing such a solid naproxen concentrate.2011-03-03
20110052680ENCAPSULATION OF OXIDATIVELY UNSTABLE COMPOUNDS - An encapsulated material containing an oxidation-sensitive core is covered by at least a dried phospholipid layer, and contains at least one phytosterol in the core, the phospholipid layer or in a further layer or layers. By using microencapsulation, oxidatively unstable materials may be provided with a synthetic protective barrier and rendered less susceptible to oxidative degradation.2011-03-03
20110052681Pharmaceutical compositions of entacapone co-micronized with sugar alcohols - The present invention relates to pharmaceutical compositions comprising entacapone or pharmaceutically acceptable salts thereof along with one or more sugar alcohols; wherein the entacapone is co-micronized with one or more sugar alcohols. The invention also relates to processes of making such compositions.2011-03-03
20110052682METHODS FOR ENHANCING THE RELEASE AND ABSORPTION OF WATER INSOLUBLE ACTIVE AGENTS - Methods for enhancing the release and/or absorption of poorly water soluble active agents are described herein. The method involves dissolving, melting, or suspending a poorly water soluble active agent in one or more molten fatty acids, conjugated fatty acids, (semi-) solid surfactants of high HLB value, and/or hydrophilic polymers. The molten active agent mixture is then suspended and homogenized in a hydrophilic or lipophilic carrier to form microparticles suspended in the hydrophilic or lipophilic carrier. The particles suspended in the hydrophilic or lipophilic carrier can be encapsulated in a hard or soft gelatin or non-gelatin capsule. It is believed that the microparticles produced by the method described above will exhibit enhanced dissolution profiles. In vitro release studies of formulations containing cilostazol and fenofibrate showed 100% dissolution of cilostazol in 15 minutes and over 90% dissolution of fenofibrate in 35 minutes.2011-03-03
20110052683PHARMACEUTICAL PREPARATION FOR TREATING CARDIOVASCULAR DISEASE - The present invention provides a pharmaceutical preparation comprising a prior-release compartment containing a hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor as a pharmacologically active ingredient, and a delayed-release compartment containing a non-dihydropyridine calcium channel blocker as a pharmacologically active ingredient. The preparation of the present invention provides synergistic effects through combined administration of the non-dihydropyridine calcium channel blocker and the HMG-CoA reductase inhibitor, and induces the time-dependent absorption, metabolism and action mechanism of individual drugs through the controlled release thereof to avoid competitive antagonism between drugs, thus maximizing the effects of each pharmacologically active ingredient while minimizing side effects, for example, the risk of myopathy, and substantially increasing the compliance of patients by taking one tablet once a day.2011-03-03
20110052684PHARMACEUTICAL COMPOSITION - The present invention relates to a pharmaceutical composition comprising a tablet core comprising a combination of actives selected from the group consisting of bupropion hydrochloride and escitalopram oxalate, bupropion hydrobromide and citalopram hydrochloride, bupropion hydrobromide and escitalopram oxalate, and bupropion hydrobromide and quetiapine fu-marate, and at least one pharmaceutically acceptable excipient, and a control-releasing coat surrounding the tablet core, wherein said composition surprisingly provides for a synchronous release of the combination of active agents in-vitro. The once-daily pharmaceutical composition surprisingly also provides for enhanced absorption of bupropion hydrobromide when administered to a subject in need of such administration.2011-03-03
20110052685GASTRIC RETENTIVE PHARMACEUTICAL COMPOSITIONS FOR IMMEDIATE AND EXTENDED RELEASE OF ACETAMINOPHEN - Gastric retentive dosage forms for extended release of acetaminophen or for both immediate and extended release of acetaminophen are described. The dosage forms allow effective pain relief upon once- or twice-daily dosing. Methods of treatment using the dosage forms and methods of making the dosage forms are also described.2011-03-03
20110052686MODIFIED RELEASE LAMOTRIGINE TABLETS - The present invention relates to uncoated modified-release tablets of lamotrigine and the process for preparation thereof, wherein the tablets comprise a portion of lamotrigine in an admixture with a pH-dependent polymer.2011-03-03
20110052687EXTENDED RELEASE PHARMACEUTICAL COMPOSITION OF PALIPERIDONE - The present invention provides an extended release tablet of paliperidone, comprising a) a core containing paliperidone and at least one water soluble and/or gellable polymer, b) a coating comprising at least one water insoluble or permeable polymer, and a water soluble and/or gellable polymer and optionally an enteric polymer.2011-03-03
20110052688SOLID DISPERSION COMPOSITION - A solid dispersion extended release tablet composition is provided. The composition comprises fluvastatin sodium and a polymer, wherein molecules of the fluvastatin sodium are separate from one another and dispersed in the polymer, and wherein the composition displays two distinct peaks at about 3.5 and 20.4.degrees 2θ of X-ray diffraction.2011-03-03
20110052689SUSTAINED RELEASE OF GUAIFENESIN - The invention relates to a novel pharmaceutical sustained release formulation of guaifenesin. The formulation may comprise a hydrophilic polymer, preferably a hydroxypropyl methylcellulose, and a water-insoluble polymer, preferably an acrylic resin, in a ratio range of about one-to-one (1: 1) to about nine-to-one (9: 1), more preferably a range of about three-to-two (3:2) to about six-to-one (6: 1), and most preferably in a range of about two-to-one (2: 1) to about four-to-one (4: 1) by weight. This formulation capable of providing therapeutically effective bioavailability of guaifenesin for at least twelve hours after dosing in a human subject. The invention also relates to a modified release product which has two portions: a first portion having an immediate release formulation of guaifenesin and a second portion having a sustained release formulation of guaifenesin. The modified release product has a maximum guaifenesin serum concentration equivalent to that of an immediate release guaifenesin tablet, and is capable of providing therapeutically effective bioavailability of guaifenesin for at least twelve hours after dosing in a human subject.2011-03-03
20110052690PROCESS FOR MANUFACTURE OF A MEDICAMENT WITH GRANULATION AND PAN COATING - A process for the manufacture of a coated tablet comprising a serotonin-norepinephrine reuptake inhibitor (SNRI), such as venlafaxine. According to one embodiment of the present invention, there is provided a process for manufacturing a coated tablet containing a serotonin-norepinephrine reuptake inhibitor, the process comprising preparing a granulate of the serotonin-norepinephrine reuptake inhibitor using a low shear granulator; compressing the granulation into a core; and applying a coating to the core using a pan coater.2011-03-03
20110052691Sustained Release Systems and Preparation Method Thereof - The present invention relates to a hydrophilic drug and β-tricalcium phosphate (β-TCP) coating on a surface area of biopolymer matrix to form a sustained release system. The present invention also provides a method for preparing a sustained release system, comprising providing a surface are of biopolymer matrix coated with a hydrophilic drug and β-TCP.2011-03-03
20110052692NOVEL HYDROGELS AND USES THEREOF - The present invention provides novel hydrogels and methods of making and using such hydrogels. The present invention provides hydrogels that may be formed by the self-assembly of peptides in solution. Such self-assembly may be brought about by a change in one or more characteristics of the solution. Characteristics of the solution that may be changed include pH, ionic strength, temperature, and concentration of one or more specific ions. In addition, hydrogels of the invention may be disassembled by changing one or more characteristic of the hydrogel such as pH, ionic strength, temperature, and concentration of one or more specific ions.2011-03-03
20110052693METHOD FOR PRODUCING ARTIFICIAL SKIN - An object of the invention is to provide artificial skin that does not contain any animal-derived material or pathogen and has excellent biocompatibility. The invention provides, as a solution means, a method for producing artificial skin comprising the steps of: (A) forming a dermal layer by solidifying a mixture of dermal fibroblasts and a peptide hydrogel having a fibrous structure; and (B) forming an epidermal layer by seeding skin keratinocytes onto the dermal layer obtained in Step (A), and culturing the epidermal keratinocytes.2011-03-03
20110052694USE OF CANNABIDIOL PRODRUGS IN TOPICAL AND TRANSDERMAL ADMINISTRATION WITH MICRONEEDLES - Described herein are microneedle drug delivery systems comprising a pharmaceutical compositions comprising pharmaceutically active agents (e.g., cannabidiol and prodrugs of cannabidiol) and microneedle arrays suitable for local and systemic delivery of the active agent to a mammal. Also described herein are methods of using a microneedle transdermal or topical drug delivery systems comprising pharmaceutical compositions, comprising cannabidiol and prodrugs of cannabidiol, and microneedle arrays in the treatment disease, including pancreatitis and pancreatic cancer.2011-03-03
20110052695DRUG DELIVERY PLATFORMS COMPRISING SILK FIBROIN HYDROGELS AND USES THEREOF - The present specification provides drug delivery platforms useful for the controlled release of a compound over time in an individual.2011-03-03
20110052696DENDRIMERS WITH INTERIOR AND EXTERIOR FUNCTIONALITIES COMPRISING OF AZIDE OR ALKYNE GROUPS FOR POST-FUNCTIONALIZATION BY THE HUISGEN CLICK CYCLOADDITION - A dendritic structure includes a core and repeating units, wherein the repeating units comprise units of the type AB2011-03-03
20110052697Aptamer-Directed Drug Delivery - The present invention provides systems, methods, and compositions for targeted delivery of a therapeutic agent organs, tissues, cells, extracellular matrix components, and intracellular compartments. The present invention provides a complex comprising a therapeutic or diagnostic agent and a nucleic acid targeting moiety, wherein the agent non-covalently associates with base pairs of the nucleic acid targeting moiety. The invention provides targeted particles comprising a particle and an inventive complex. The present invention provides methods of designing, manufacturing, and using inventive complexes and targeted particles.2011-03-03
20110052698NOVEL MATERIAL WITH BACTERIOSTATIC PROPERTIES - The invention relates to a method for making a composite material including a porous polymer matrix containing HEMA monomers and in which silver nanoparticles are dispersed, and to the use thereof as an anti-microbial material.2011-03-03
20110052699DRUG DELIVERY SYSTEM WITH STABILISING EFFECT - A drug delivery system also intended as unit dosage form comprising a thin water-soluble film matrix, wherein said film matrix comprises 2011-03-03
20110052700GASTRIC RETENTIVE PHARMACEUTICAL COMPOSITIONS FOR IMMEDIATE AND EXTENDED RELEASE OF LEVOSULPIRIDE - Gastric retentive oral dosage forms which provide both immediate and extended release of levosulpiride are described which may allow once- or twice-daily dosing. Methods of treatment using the dosage forms and methods of making the dosage forms are also described.2011-03-03
20110052701PARTICULATES OF A CRTH2 ANTAGONIST - Provided herein are particulates of {4,6-bis(dimethylamino)-2-(4-(4-(trifluoromethyl)benzamido)benzyl)pyrimidin-5-yl} acetic acid in amorphous or crystalline forms, processes for their preparation, pharmaceutical compositions comprising them, and methods of their use for treating, preventing, or ameliorating one or more symptoms of a CRTH2-mediated disorder or disease.2011-03-03
20110052702Method and Apparatus for Producing Organic Nanotubes - An object of the present invention is to provide a method and apparatus capable of continuously producing organic nanotubes, wherein an organic nanotube material dispersion solution consisting of an organic nanotube material and an organic solvent is pressurized and caused to pass through a very narrow orifice.2011-03-03
20110052703BETA-CASEIN ASSEMBLIES FOR MUCOSAL DELIVERY OF THERAPEUTIC BIOACTIVE AGENTS - Nanoparticulate assemblies of isolated beta-casein, are useful for encapsulation of bioactive therapeutic substances, particularly therapeutic agents with poor bioavailability. These nano-sized beta-casein assemblies are preferably formed at pH values which are at least one or more pH units below or above the pI of the protein. Pharmaceutical compositions comprising the beta-casein micelles may be used to administer the agents to the GI tract for treatment of local or systemic conditions. These carriers are stable over a wide temperature range (optionally at least from about 1° C. to at least about 45° C.).2011-03-03
20110052704TOCOTRIENOL COMPOSITIONS - Compositions containing tocotrienol, non-tocotrienol lipids and surface active agents; compositions containing particles having a statin and a tocotrienol wherein the particle size is less than 1000 nm; and microemulsions containing a statin and a tocotrienol are disclosed. Methods relating to the creation of such compositions and the use of such compositions are further disclosed.2011-03-03
20110052705CARTILAGE COMPOSITION AND PROCESS FOR PRODUCING THE CARTILAGE COMPOSITION - Disclosed is a method for regenerating articular cartilage in an animal comprising administering a therapeutically effective amount of a non-demineralized particulate articular cartilage having a distribution of particle sizes within the range of from about 60 microns to about 500 microns.2011-03-03
20110052706Pancreatine pellets and method of producing same - In order to prevent impairment of the pharmacological effect of pancreatine through added auxiliary substances or binding agents a pancreatine pellet consists exclusively of pancreatine.2011-03-03
20110052707COMBINATION OF VITAMIN D AND 25-HYDROXYVITAMIN D 3 - We disclose compositions comprising Vitamin D (cholecalciferol and/or ergocalciferol) and 25-OH D3 (calcifediol), and use of those compositions to affect at least concentration, bioavailability, metabolism, or efficacy of vitamin D in a human. Forms and dosages of the composition, as well as processes for manufacturing a spray-dried formulation, are also disclosed.2011-03-03
20110052708METHODS AND FORMULATIONS FOR THE DELIVERY OF PHARMACOLOGICALLY ACTIVE AGENTS - In accordance with the present invention, novel formulations have been developed which are much more effective for the delivery of hydrophobic drugs to patients in need thereof than are prior art formulations. Invention formulations are capable of delivering more drug in shorter periods of time, with reduced side effects caused by the pharmaceutical carrier employed for delivery.2011-03-03
20110052709NOVEL NANOPARTICLES FOR DELIVERY OF ACTIVE AGENTS - Milled nanoparticles comprising a biologically active agent, at least one biopolymer and a coating containing at least one coating which is a polymer or ligand are produced using milling and coating techniques which have not previously been used for these applications.2011-03-03
20110052710NOVEL NANOPARTICLES FOR DELIVERY OF ACTIVE AGENTS - Milled nanoparticles comprising a biologically active agent, at least one biopolymer and a coating containing at least one coating which is a polymer or ligand are produced using milling and coating techniques which have not previously been used for these applications.2011-03-03
20110052711CONTROLLED RELEASE MULTIDRUG FORMULATIONS FOR SPINAL CORD INJURY - A controlled release multidrug formulation for improving locomotor recovery after spinal cord injury comprising: (a) a first composition comprising a first bioactive agent, encapsulated within a first polymeric particle; (b) a second composition comprising a second bioactive agent, encapsulated within a second polymeric particle, wherein the second polymeric particle is encapsulated within the first polymeric particle; and (c) a third composition comprising a third bioactive agent, encapsulated within either the first or the second polymeric particle, wherein the second composition is released subsequently to the release of the first composition, and wherein the first bioactive agent is a neurotrophic factor, the second bioactive agent is a collagen synthesis inhibitor, and the third bioactive agent is selected from the group consisting of cyclic AMP (cAMP), an adenylate cyclase activator and a Rho inhibitor.2011-03-03
20110052712Sprayable Polymers As Adhesion Barriers - A formulation for generating an adhesion barrier that includes a plurality of particles or a dry powder that is made of a polymer combination of at least one biodegradable polymer and at least one water soluble polymer is disclosed. Methods of making and delivering the formulation are further disclosed. The formulation of particles is deposited on a surface of internal body tissue and the deposited formulation absorbs moisture from the tissue and forms a film over the surface. The film acts as an adhesion barrier by reducing or preventing adhesion of the surface to other body tissue.2011-03-03
20110052713REPAIRING DAMAGED NERVOUS SYSTEM TISSUE WITH NANOPARTICLES - The present application relates to reduction of acrolein-mediated cell death following neural insult. According to at least one embodiment, chitosan is utilized as a membrane fusogen to restore cell function. According to at least one other embodiment, chitosan or silica is used to create a non-toxic polymer surfaced microcolloid (PSM). PSMs were found to preferentially target the damaged nerve tissues; to restore conduction of nerve impulses; to seal/restore nerve fiber membranes; and to reduce to baseline the efflux of a large intracellular enzyme. PSMs are further used as a drug delivery vehicle for acrolein scavengers including hydralazine.2011-03-03
20110052714ORGANIC POLYMER-INORGANIC FINE PARTICLE ANTIMICROBIAL COMPOSITES AND USES THEREOF - An embodiment relates to a composition comprising a noble-metal containing nanoparticle and a polymer located on a surface of the nanoparticle, wherein the polymer is a polycondensation product of a halogenated monomer. Other embodiments relate to the method of making a composition and providing antimicrobial treatment using the composition.2011-03-03
20110052715NANOPARTICLE AND POLYMER FORMULATIONS FOR THYROID HORMONE ANALOGS, ANTAGONISTS, AND FORMULATIONS AND USES THEREOF - Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric nanoparticle form of thyroid hormone agonist, partial agonist or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Nanoparticle forms of thyroid hormone or thyroid hormone analogs as well as uses thereof are also disclosed.2011-03-03
20110052716Adjuvant Comprising Aluminum, Oligonucleotide and Polycation - An immunological adjuvant comprises an aluminium salt, an immunostimulatory oligonucleotide and a polycationic polymer, wherein the oligonucleotide and the polymer ideally associate with each other to form a complex. The adjuvant can be included in a composition with an immunogen e.g. to elicit an immune response that protects against a bacterial disease or a fungal disease.2011-03-03
20110052717SLOW RELEASE PHARMACEUTICAL COMPOSITION MADE OF MICROPARTICLES - Pharmaceutical composition made of microparticles for the slow release of an active substance at least during a period covering the 6th month after injection of said composition, said composition comprising a group of microparticles made of a copolymer of the PLGA type which incorporate an active substance in the form of a water insoluble peptide salt; said copolymer furthermore comprising at least 75% of lactic acid and an inherent viscosity between 0.1 and 0.9 dl/g, as measured in chloroform at 25° C. and at a polymer concentration of 0.5 g/dL; said microparticles furthermore having a size distribution defined as follows: D (v,0.1) is between 10 and 30 micrometers, D (v,0.5) is between 30 and 70 micrometers, D (v,0.9) is between 50 and 1 10 micrometers.2011-03-03
20110052718Synergistic Phytoceutical Compositions - Phytoceutical compositions for the prevention and treatment of circulatory disorders, feminine endocrine disorders, and dermal disorders. A specific combination of extracts of plants is taught, as well as principles for varying the formulations based on categorizing plants into one of three groups, Energy, Bio-Intelligence, and Organization and selecting several plants from each group. Such combinations have synergistic effects, with minimal side effects.2011-03-03
20110052719DERMATOLOGICAL COMPOSITION THAT CAN BE USED IN PARTICULAR FOR THE CARE AND PREVENTION OF ESCHARS - The invention relates to a composition formulated for a topical application to the skin containing, as essential constituents, peroxide lipids that have a degree of peroxidation between 30 and 500 milliequivalents per kg of peroxide lipids and cod liver oil. This composition can be used as a medical device, in order to form a protective film on the skin, especially for the care of irritated skin and/or skin that has red spots and/or skin that has superficial lesions, and/or as an adjuvant in skin massaging operations. It is most particularly useful for the care and/or prevention of eschars.2011-03-03
20110052720COMPOSITIONS FOR THE CONTROL OF PLANT PATHOGENS AND FOR USE AS PLANT FERTILIZER - The present invention relates to a composition comprising a metal compound, a lignosulfonate and phosphorous acid and/or a salt and/or a hydrate and/or an ester thereof and its use as fungicide, bactericide or fertilizer and its use in preventing the formation of a metal phosphite precipitate in an aqueous composition. The composition is preferably an aqueous composition comprising 0.1 wt. % to 40 wt. % of dry matter, calculated on the total weight of the aqueous composition. The present invention also relates to a process for preparing the aqueous composition.2011-03-03
20110052721INTRA-MAMMARY TEAT SEALANT FORMULATION AND METHOD OF USING SAME TO REDUCE OR ELIMINATE VISUAL DEFECTS IN AGED CHEESES - Described is an intra-mammary teat sealant and a corresponding method of forming a physical barrier in the teat canal of a non-human animal for prophylactic treatment of mammary disorders during the animal's dry period. The method includes the step of infusing a bismuth-free teat seal formulation into the teat canal of the animal. The method also prevents the formation of black spot defect in dairy products, especially cheddar cheese, made from the milk of animals so treated.2011-03-03
20110052722Toleration Iron Supplement Compositions - The invention relates to compositions and methods for the treatment or prophylaxis of iron deficiency, and in particular of iron deficiency anemia, by administering a composition containing an effective amount of a pharmaceutically acceptable ferrous iron salt; and an effective amount of polysaccharide iron complex.2011-03-03
20110052723USE OF COMPOUNDS BINDING TO THE SIGMA RECEPTOR LIGANDS FOR THE TREATMENT OF NEUROPATHIC PAIN DEVELOPING AS A CONSEQUENCE OF CHEMOTHERAPY - The present invention refers to the use of compounds binding to the sigma receptor for the treatment or prevention of neuropathic pain resulting from chemotherapy.2011-03-03
20110052724CALCIUM HYPOCHLORITE COMPOSITIONS - Described are compositions containing a mixture of (a) particulate calcium hypochlorite and (b) an amount of aluminum hydroxide that is sufficient to increase the UN-burn time of the composition by a factor of at least 2.5 compared to that of the calcium hypochlorite, the composition having an available chlorine content of at least 35 weight percent. Further described are solid compositions of (a) granular calcium hypochlorite having a UN Packing Group oxidizer classification of II, and (b) an amount of aluminum hydroxide such that the composition is classified as a Packing Group III Division 5.1 oxidizer or as a non-Division 5.1 oxidizer, the composition having an available chlorine content of at least 40 weight percent. Further described are formed articles prepared from the above-described compositions.2011-03-03
20110052725THERAPEUTIC AGENT FOR INFECTIOUS SKIN AND MUCOSAL DISEASE - A therapeutic agent for infectious skin and mucosal diseases to be applied to an infected area for ameliorating a symptom of the infected area caused by infection with a pathogenic microorganism includes: a chlorine dioxide solution including a dissolved chlorine dioxide gas.2011-03-03
20110052726SOLID-LAYERED BLEACH COMPOSITIONS AND METHODS OF USE - The present invention provides a solid-layered composition having at least two parts. The first part comprises a) calcium hypochlorite, magnesium hypochlorite and mixtures thereof, b) a builder, c) a water-soluble polymer, d) an acid, and e) wherein the first part does not contain sodium hypochlorite, lithium hypochlorite, potassium hypochlorite and mixtures thereof. The second part comprises a) a functional ingredient, b) a builder or filler, and c) wherein the second part does not contain any oxidant.2011-03-03
20110052727Anti Influenza Nutritional Supplements - The invention presents nutritional supplements with anti influenza activities. In a preferred embodiment, the invention features administration to a subject an effective dose of a nutritional supplement that includes a combination of all or some of the following ingredients licorice, quercetin, green tea, cinnamon, propolis, and selenium.2011-03-03
20110052728BOTANICAL EXTRACT FROM THE AQUEOUS STREAM OF THE PALM OIL MILLING PROCESS FOR THE PREVENTION AND INHIBITION OF OXIDATIVE STRESS AND HAEMOLYSIS IN HUMAN RED BLOOD CELLS - The invention provides a composition for the prevention and inhibition of oxidative stress and haemolysis in human red blood cell wherein said composition compounds obtained from the aqueous stream of palm oil milling (palm oil vegetation liquor), in particular from vegetative liquor from the milling of palm oil fruit.2011-03-03
20110052729Pharmaceutical or nutraceutical composition - The invention relates to a pharmaceutical or nutraceutical composition comprising an alkalized organic substance selected from the group comprising proteins, carbohydrates, lipids, amino acids, vitamins, therapeutic agents and mixtures thereof. Such compositions are useful for treating a range of diseases and conditions. They also give rise to beneficial physiological effects such as, for example, increasing physical strength, muscle mass and endurance.2011-03-03
20110052730Leaves Extract of Panax sp., a Process of Making the Same and Uses Thereof - The present invention relates to a composition for improvement of exercise performance, fatigue recovery or prevention of oxidation response comprising 2011-03-03
20110052731MEDICINAL PLANTS EXTRACT USING PROCESSING OF HERBAL MEDICINE AND COMPOSITION OF SKIN EXTERNAL APPLICATION COMPRISING THE SAME - The present invention relates to an extract of a processed herbal medicinal plant and a composition for skin external application which contains the extract. More specifically, the composition for skin external application contains an extract of processed herbal medicinal plant, prepared through a method comprising the steps of: (a) processing an herbal medicinal plant by a process of boiling, steaming, roasting, baking or heating the medicinal plant or a combination of two or more of these processes; (b) obtaining an extract of the processed medicinal plant. The composition shows an improved antioxidant effect.2011-03-03
20110052732MINERAL ABSORPTION ACCELERATOR AND IRON DEFICIENCY ANEMIA IMPROVER OF FOOD COMPOSITION - A mineral absorption accelerator, and an anemia improving agent, food and drink or food and drink material containing the mineral absorption accelerator are provided, the mineral absorption accelerator including: an α-glucosidase inhibitory component.2011-03-03
20110052733HERBAL COMPOSITIONS FOR THE TREATMENT OF MUCOSAL LESIONS - The present invention provides therapeutic compositions comprising extracts of the plant species 2011-03-03
20110052734Transparent Oil Gelling System - The invention relates to a gellant system for a polar oil comprising gellant effective amounts of silica, a sugar fatty acid ester and a long chain polymer. The gellant system of the invention is useful in gelling polar oils to produce transparent or translucent gels useful in topical compositions.2011-03-03
20110052735SHAMPOO WITH FRUIT JUICE AND/OR VEGETABLE JUICE - Shampoos providing hair treated therewith improved strength, handle and tensile strength, as well as combability in the dry and wet states and, at the same time, are particularly mild and ecologically compatible, and contain, in a cosmetically acceptable carrier, 0.1 to 35% by weight of at least one surfactant and 15 to 85% by weight of at least one fruit juice or vegetable juice.2011-03-03
20110052736METHODS AND MATERIALS FOR REDUCING OR ELIMINATING RISK FACTORS ASSOCIATED WITH SYNDROME X - A composition containing cinnamon extract reduces and/or eliminates one or more risk factors associated with Syndrome X. The composition also includes optionally one of more components selected from the group consisting of vitamins, cholesterol lowering agents, lipid lowering agents, and glucose lowering agent. Also described is a method of reducing and/or eliminating risk factors associated with Syndrome X in a subject through the administration of the cinnamon extract. The cinnamon extract supplement is administered orally, intravenously, or subcutaneously. In one embodiment, a daily dose of 10-1,000 mg of the cinnamon extract supplement is administered to the subject for a period of 6 weeks to 6 months.2011-03-03
20110052737TOPICAL SKIN FORMULATIONS COMPRISING BOTANICAL EXTRACTS - Disclosed are compositions and corresponding methods of their use that include 2011-03-03
20110052738TOPICAL PAIN FORMULATION - A topical pain formulation, comprising one or more analgesic compounds and a plurality of skin penetrants.2011-03-03
20110052739Active Ingredient That Stimulates the Proliferation and/or Activity of Fibroblasts - The invention relates to a novel active ingredient that stimulates the proliferation and/or the activity of fibroblasts and also to its applications in the cosmetic or pharmaceutical, in particular dermatological, field. In particular, the active ingredient according to the invention comprises a combination of at least one 2011-03-03
20110052740Skin Circulation-Improving Agent And Skin Temperature-Elevating Agent - Skin blood circulation is improved, skin temperature is increased, or shoulder stiffness or sensitivity to cold is prevented or improved by using, as an active ingredient, at least one of the members selected from the group consisting of an Arabian jasmine (matsurika, jasmin sambac) extract, a damask rose (2011-03-03
20110052741Composition and Method for Skin Repair - A composition and a method of using the composition is described that is effective to protect or repair oxidative damage to DNA in mammalian skin by up regulating each of SIRT1, Gadd45b, and SOD2. The composition includes at least two of a candle bush extract, noni leaf extract, and melon extract with each present in an amount such that the composition is effective to up regulate each of SIRT1, Gadd45b, and SOD2.2011-03-03
20110052742MOLD CLAMPING APPARATUS - There is provided a mold clamping apparatus that can prevent a molding material from spouting from a split surface of a mold even if in-cavity resin pressure causes offset of a mold opening force, and can extend the life of the mold. The mold clamping apparatus includes a control device that estimates a mold opening force by mold internal pressure for molding with mold internal pressure being asymmetrical with respect to a center of a mold block, determines a mold clamping hydraulic value applied to each time bar correspondingly to the estimated mold opening force, and distributes hydraulic pressure supplied to each tie bar so that the determined mold clamping hydraulic value is reached.2011-03-03
20110052743MOLDING UNIT ATTACHMENT SYSTEM AND MOLDING UNIT COMPRISING SUCH A SYSTEM - The invention relates to a molding unit attachment system enabling the attachment of at least one interchangeable molding part (2011-03-03
20110052744MAGAZINE APPARATUS FOR THE STORAGE OF BLOW MOULDS AND METHODS OF STORING BLOW MOULDS - A magazine apparatus including a plurality of receiving elements that are constructed and arranged to separately receive individual blow moulds each having a plurality of parts and each configured to shape plastic-material pre-forms into plastic-material containers. The magazine apparatus being constructed and arranged to store a plurality of blow moulds outside the working operational area of a blow moulding machine.2011-03-03
20110052745Honeycomb Extrusion Die Apparatus And Methods - Honeycomb extrusion die apparatus include a die body including a first set of die pins circumscribed by a second set of die pins. At least a portion of the end face of die pins of the second set of die pins are positioned along a peripheral surface extending at an oblique angle with respect to the extrusion direction. A lateral width of the open end of a plurality of discharge slots defined by the second set of die pins is larger than a lateral width of the open end of a plurality of discharge slots defined by the first set of die pins. Methods of making a honeycomb extrusion die apparatus are also provided.2011-03-03
20110052746DIE HEAD FOR FORMING A MULTI-LAYER RESIN AND AN EXTRUSION-FORMING MACHINE HAVING THE SAME - A die head is provided with a plunger and a measuring chamber, and the molten resin is uniformly fed to the die head of an extrusion-forming machine. That is, the die head comprises a main layer-forming flow passage for flowing a molten resin into an ejection port of the die head of the extrusion-forming machine passing through the die head, and a core layer-forming flow passage for intermittently flowing a molten resin into the ejection port of the die head passing through the die head. The main layer-forming flow passage and the core layer-forming flow passage are provided with measuring chambers into which the molten resins are pressure-introduced from the upstream sides of the flow passages due to the pressure-feeding forces of the molten resins, and the measuring chambers are provided with plungers which move back due to the pressure-feeding forces of the molten resins and eject the measured molten resins to the downstream side of the flow passage, and the amounts of ejecting the molten resins by said plungers and the ejection timings are controlled by control units that control the plungers.2011-03-03
20110052747APPARATUS FOR THE SHAPING OF PLASTICS-MATERIAL CONTAINERS WITH A BLOW MOULD - An apparatus for the shaping of plastics-material containers with a blow mould, wherein the blow mould has at least one first and one second blow-mould part, may include at least one first and one second carrier element for holding the blow-mould parts. The carrier elements are movable relative to one another at least in one plane, in order to be transferred at least from a closed configuration into an opened configuration. In this case the carrier elements each have a receiving area for receiving one blow-mould part in each case, wherein the blow-mould parts in the closed configuration form at least one cavity for the expansion of the containers. The blow-mould parts may be capable of being coupled in a magnetic and releasable manner to each other and/or at least one of the blow-mould parts is capable of being coupled in a magnetic and releasable manner to at least one carrier element.2011-03-03
20110052748Mould cavity with decoupled cooling-channel routing - The present invention relates to a cavity for a mould-cavity system for the production of hollow mouldings, where the cavity (2011-03-03
20110052749MOVABLE PLATEN SUPPORT MECHANISM - An injection molding machine is provided with a linear guide block configured to be guided on a linear guide rail and a guide mounting block which is secured to the linear guide block and supports the movable platen. Two mounting bolts and two adjust bolts are disposed individually at two positions, spanning between the movable platen and the guide mounting block. The size of a gap between the movable platen and the guide mounting block is adjusted by independently tightening the adjust bolts, whereby the horizontal tilt of the movable platen is adjusted.2011-03-03
20110052750OLIVE JUICE EXTRACTS FOR PROMOTING MUSCLE HEALTH - Olive extracts comprising hydroxytyrosol are effective in promoting muscle health in both animals and humans which are subject to muscle damage, muscle pain and muscle soreness due to exercise. The olive extracts can decrease the accumulation of lactic acid present post-exercise, and can also work by maintaining glutathione levels.2011-03-03
20110052751FEED COMPOSITION FOR COMPANION ANIMALS - The present invention relates to animal feed compositions which are useful for balancing body weight in companion animals and which after ingestions results in reduced calorie intake at a subsequent meal. It has been found surprisingly that the calorie intake of a pet can be reduced without negative effects towards the begging behavior of the unsatisfied pet which often results in a over-feeding by the owner when the daily feed intake of the diet (preferably a calorie-restricted diet) is combined with the intake of a mixture of triglyceride oils having a solid fat content at ambient to body temperature and an emulsifier, a mixture hereinafter abbreviated by “oil-composition”.2011-03-03
20110052752ROTATIONAL PET-FOOD FORMULATION AND METHOD - Compositions and methods are disclosed for providing a rotational pet-food diet to a pet. Rotational pet-food formulas are provided that enable a pet owner to cycle a pet's diet through a sequence of different pet-food formulas that are digestively compatible and developed to nutritionally complement one another. The rotational pet-food formulas may be packaged together and sold as a single point-of-purchase unit.2011-03-03
20110052753COMPOSITIONS AND METHODS FOR INFLUENCING RECOVERY FROM STRENUOUS PHYSICAL ACTIVITY - Compositions and methods for influencing the recovery of an animal from the effects of strenuous physical activity. The compositions generally comprise about 4% to 6% readily absorbable carbohydrate; about 10% to 30% maltodextrins; about 20% to 50% starch, for a total of about 40% to 80% carbohydrate; about 20% to about 40% protein; and optionally one or more antioxidants. The methods generally comprise administering the composition to an animal within the period from about 120 minutes before initiation of or 120 minutes after completion of the physical activity.2011-03-03
20110052754Weight Loss Composition and Method - A composition is provided for promoting weight loss. This comprises a component for supporting healthy thyroid function; a component for increasing satiety; a component for inhibiting carbohydrate uptake and usage; a component for increasing calorie expenditure; and a component for increasing fatty acid oxidation therefore improving lean body composition. A method promoting weight loss in a human is also provided. The method comprises the following steps: supporting healthy thyroid function; increasing satiety; inhibiting carbohydrate uptake and usage; increasing calorie expenditure; and increasing fatty acid oxidation therefore improving lean body composition.2011-03-03
20110052755SWEETENER COMPOSITIONS - Provided is a sweetener composition comprising: an extract from the leaves of the 2011-03-03
20110052756CHEWING GUM MANUFACTURE - A chewing gum sheet is formed without substantial use of a powdered non-stick agent by extruding a slab having a tacky surface of heated chewing gum composition onto a moving conveyor; cooling the slab on the conveyor sufficiently to cool the surface of the slab; and passing the slab from the conveyor through at least one cooled roller to form a chewing gum sheet with predetermined dimensions.2011-03-03
20110052757NOVEL SIALIDASE - The present invention relates to a process for the preparation of fermented food wherein a carboxypeptidase preparation is used to obtain accelerated fungal growth.2011-03-03
20110052759PROCESS TO EXTRACT DRINKING WATER FROM PLANT, PLANT DRINKING WATER AND BEVERAGES THEREOF - There is provided a process to extract drinking water from a plant, which comprises the steps of: a) filtrating collected plant sap to separate plant water content from concentrated plant extract; and b) disinfecting the separated plant water content to remove or inactivate microorganism to obtain plant drinking water. and the process may further comprise step c) bottling the plant drinking water. There is also provided plant drinking water prepared according to the process and a liquid beverage containing plant drinking water and nutriments and/or dietary minerals extracted from plants and optionally any flavoring ingredients.2011-03-03
20110052760SOUP OR SAUCE COMPOSITION AND PROCESS FOR ITS PRODUCTION - A soup or sauce comprising: water; one or more components selected from meat ingredients, vegetable ingredients and carbohydrates; and from 0.5 to 20% by weight added fat, wherein said fat comprises at least 5 to 35% by weight pinolenic acid.2011-03-03
20110052761CAPSULE SYSTEM FOR THE PREPARATION OF BEVERAGES BY CENTRIFUGATION - A capsule system for preparing beverages by centrifugation of a capsule in a centrifuging brewing device. The system includes a set of different capsules each one for selectively delivering a beverage having specific characteristics that differ from the other capsules of the set. The capsules have a body with a sidewall and a free rim, an upper wall and an extractable or infusible ingredient therein. The capsules are configured with an insertion diameter of the body of the capsule designed for insertion in a rotary capsule holder of the centrifuge brewing device in a referential position, wherein the different capsules in the set having bodies of different storage volumes obtained by a variable depths of the body in the set but the same insertion diameter for all capsules of the set.2011-03-03
20110052762Package With a Food Product Therein and Machine for Manufacturing a Packaged Food Product - A package with a food product therein is provided and, in particular, with a coffee product, comprising at least an inner package and at least an outer package, and having at least one means for reclosing provided on the inner package and/or on an inner side of the outer package. Alternatively, the inner package may comprise a vacuum-packed inner package with an outer package. A machine for producing a packaged food product is also provided and, in particular, for producing a packaged coffee product. The machine comprises at least one device for applying a means for reclose to the inner package and/or to the inner side of the outer package, the device provided in the machine direction upstream of a device for providing the at least one outer package around the at least one inner package.2011-03-03
20110052763USE OF SOLUBLE TOMATO SOLIDS FOR REDUCING THE SALT CONTENT OF FOOD PRODUCTS - The present invention is primarily directed to a method for reducing the amount of sodium chloride in a food product without adversely affecting the salty taste thereof, comprising adding soluble tomato solids (STS) to said food product and reducing the amount of salt normally added thereto. In a preferred embodiment of this method, the STS used is characterized in having an acidity level, formol number and color intensity within certain defined ranges or with defined minimal/maximal values.2011-03-03
20110052764NUTRITIONAL PRODUCT DISPENSER - An apparatus for dispensing nutritional products including a number of storage hoppers for powdered ingredients, a controllable outlet connected to each storage hopper and operable to release controlled amounts of the powdered ingredients, a controllable liquid supply, a mixer, and a control system including a user interface for capturing data from a user. The control system uses the data that the user inputs to determine the quantity of each powdered ingredient and the quantity of liquid to be released to create a nutritional product, and sends signals to the liquid supply and the outlets to release the determined quantity of liquid and each powdered ingredient into the mixer to be mixed before being dispensed into a container.2011-03-03
20110052765MARINADE INJECTOR - A device, system, and method for injecting an injection substance into one or more food objects is provided. The system further provides for detection of the position of injectors relative to the food objects to selectively provide and remove injection pressure to the injectors and to selectively provide and remove movement to the food objects.2011-03-03
20110052766BREWER SYSTEM INCLUDING PERVASIVE RFID SENSING FOR SERVERS - An apparatus, system, and method for use with beverages and beverage making and dispensing equipment. The apparatus, system, and method of use monitors characteristics of the beverage, reports characteristics, or both and selectively affects the beverage and beverage making and dispensing equipment, a server containing the beverage, or both. The apparatus, system, and method of use employs an information vehicle device associated with each beverage server or dispenser and a reader which reads the information device. The reader communicates the information from the information device to a controller for use to individually or collectively display information, collect information, and/or selectively affect the condition of the beverage in response to the information.2011-03-03
20110052767Method and system for determining level of doneness in a cooking process - A method and apparatus for determining when meat is cooked to a desired degree of doneness, the method continuously calculating the arithmetic integral of the meat's temperature (T) minus some threshold temperature (T2011-03-03
20110052768Container Closure with Overlying Needle Penetrable and Resealable Portion and Underlying Portion Compatible with Fat Containing Liquid Product, and Related Method - A container and method are provided for storing fat containing liquid products. The container includes a body defining a storage chamber for receiving the product, and a container closure. A first material portion forms at least most of the surface area overlying the storage chamber that can contact any product therein. Neither the body nor the first material portion leach more than a predetermined amount of leachables into the product or undesirably alter a taste profile thereof. A needle penetrable and thermally resealable second material portion either (i) overlies the first material portion and cannot contact any product within the storage chamber, or (ii) forms a substantially lesser surface area overlying the storage chamber that can contact any product therein in comparison to the first material portion. A sealing portion is engageable with the body to form a substantially dry hermetic seal between the container closure and body.2011-03-03
20110052769PROCESS FOR SPRAYING NATAMYCIN ONTO BAKERY PRODUCTS AND USE OF HEAT FOR THE REMOVAL OF SOLVENT FROM BAKED PRODUCTS - The present invention provides a process for increasing the shelf life of bakery products, comprising baking a shaped dough in an oven; placing the shaped baked product on a bed, spraying a solution or suspension of natamycin in a solvent onto the surfaces of said shaped baked product, said spray being provided from sprayers located in at least two directions so as to deposit natamycin in an amount from 0.5 to 10 μg per cm2011-03-03
20110052770INCLUSION/INCORPORATING VISCOUS MATERIAL INTO MUSCLE MEAT - A method of increasing the mass of muscle meat, such as trimmed fish fillet or fish loin. As the invention pertains to fish products, up to approximately twenty percent of the muscle mass of the fish fillet or fish loin is removed during routine trimming operations which is ground to create a quantity of ground trimmings having a solids content of at least five percent by weight. The ground trimmings are fed to a volumetric chamber and injected within the trimmed fish fillet or fish loin to increase its mass in a form representing natural muscle flake2011-03-03
20110052771PROCESS AND PRODUCT - Process for producing a chocolate or chocolate-like product comprising mixing together components of chocolate or chocolate-like product to give a flowable powder mixture, and feeding the flowable powder mixture to a roller compactor whereby the powder mixture is compressed to give the chocolate or chocolate-like product. The process can produce a chocolate or chocolate-like product comprising a compressed mass of particles of chocolate components.2011-03-03
20110052772FOODSTUFF TREATMENT COMPOSITION - A foodstuff treatment composition, particularly for the treatment of meat, meat products, fish and seafood products, the composition comprising a combination of sodium lactate and/or potassium lactate and at least one sodium and/or potassium phosphate salt, and the composition is in the form of a powder, granules, a slurry or a paste.2011-03-03
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