07th week of 2022 patent applcation highlights part 25 |
Patent application number | Title | Published |
20220049248 | MODULATORS OF IRF5 EXPRESSION - The present embodiments provide methods, compounds, and compositions useful for inhibiting IRF5 expression, which may be useful for treating, preventing, or ameliorating a disease associated with IRF5. | 2022-02-17 |
20220049249 | DOUBLE-STRANDED OLIGONUCLEOTIDE, COMPOSITION AND CONJUGATE COMPRISING DOUBLE-STRANDED OLIGONUCLEOTIDE, PREPARATION METHOD THEREOF AND USE THEREOF - Provided is a modified double-stranded oligonucleotide, in which the sense strand comprises a nucleotide sequence 1, the anti-sense strand comprises a nucleotide sequence 2, the nucleotide sequences 1 and 2 are both 19 nucleotides in length, and in the direction from 5′ end to 3′ end, nucleotides at positions 7, 8 and 9 of the nucleotide sequence 1 and nucleotides at positions 2, 6, 14 and 16 of the nucleotide sequence 2 are all fluoro-modified nucleotides, and each nucleotide at other positions is independently one of non-fluoro-modified nucleotides. Further provided are a pharmaceutical composition and a conjugate comprising the oligonucleotide, and pharmaceutical use thereof. | 2022-02-17 |
20220049250 | Antisense Oligonucleotides Rescue Aberrant Splicing of ABCA4 - The present invention relates to the field of medicine. In particular, it relates to novel antisense oligonucleotides that may be used in the treatment, prevention and/or delay of Stargardt disease | 2022-02-17 |
20220049251 | dsRNA Directed to Coronavirus Proteins - Disclosed are compositions that include double-stranded ribonucleic acid (dsRNA) constructs that inhibit expression or translation of a Coronavirus protein, and methods of using them to treat MERS, SARS, Covid-19 and/or symptoms thereof. Some embodiments relate to a method for preventing, treating, inhibiting, or ameliorating a MERS, SARS, or Covid-19 symptom using a composition herein disclosed. In some embodiments the composition targets the lung. | 2022-02-17 |
20220049252 | CHEMICALLY-MODIFIED RNAi CONSTRUCTS AND USES THEREOF - The present invention relates to chemically-modified RNAi constructs for reducing expression of a target gene. In particular, the invention relates to specific patterns of modified nucleotides to be incorporated into RNAi constructs to improve in vivo stability and efficacy. Also described are pharmaceutical compositions comprising the chemically-modified RNAi constructs and methods of inhibiting target gene expression in vivo by administering the chemically-modified RNAi constructs, for example, to treat or ameliorate various disease conditions. | 2022-02-17 |
20220049253 | COMPOSITIONS AND METHODS FOR INHIBITION OF EXPRESSION OF APOLIPOPROTEIN C-III (APOC3) GENES - The invention relates to double-stranded ribonucleic acid (dsRNA) targeting an APOC3 gene, and methods of using the dsRNA to inhibit expression of APOC3. | 2022-02-17 |
20220049254 | KLF11 siRNA For Treatment Of Diabetes And Obesity - The present invention relates to methods and compositions comprising an inhibitor of KLF11 signaling for treatment of gastrointestinal motility disorders, obesity and diabetes. | 2022-02-17 |
20220049255 | MODULATING THE CELLULAR STRESS RESPONSE - Methods of using B2 or Alu nucleic acids, or antisense oligonucleotides that modulate the EZH2/B2 or EZH2/Alu interaction and have the capacity to alter cleavage of B2 and Alu RNA, for increasing or decreasing cell and organismal viability. | 2022-02-17 |
20220049256 | CONTROL OF PLANT PESTS USING RNA MOLECULES - Disclosed are double stranded RNA (dsRNA) molecules that are toxic to insect pests. In particular, interfering RNA molecules capable of modulating expression of a pest insect target gene and that are toxic to the insect pest are provided. Further, methods of making and using the interfering RNA, for example as the active ingredient in an insecticidal composition or in a transgenic plant, to confer protection from insect damage are disclosed. | 2022-02-17 |
20220049257 | ANTISENSE NUCLEIC ACIDS - Provided is a drug that allows highly-efficient skipping of exon. The present invention provides an antisense oligomer wherein two or more unit oligomers targeting sequences that are neither consecutive nor overlap with each other in the same exon are connected. | 2022-02-17 |
20220049258 | APTAMER AGAINST IRINOTECAN - The present invention relates inter alia to aptamers that specifically bind to Irinotecan and methods of using the same. | 2022-02-17 |
20220049259 | METHODS AND MICROORGANISMS FOR MAKING 2,3-BUTANEDIOL AND DERIVATIVES THEREOF FROM C1 CARBONS - Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as 2,3-BDO are disclosed. For example, genetically modified methanotrophs that are capable of generating 2,3-BDO at high titers from a methane source are disclosed. Methods of making these genetically modified microorganisms and methods of using them are also disclosed. | 2022-02-17 |
20220049260 | INDUCIBLE EXPRESSION SYSTEM FOR PLASMID-FREE PRODUCTION OF A PROTEIN OF INTEREST - A genome-based expression system for production of a protein of interest (POI) in a prokaryotic host, comprising at least an RNA polymerase (RNAP) gene, a gene encoding a POI, comprising a coding sequence, a promoter operably linked to said coding sequence, wherein said promoter is recognized by the RNAP expressed from the RNAP gene, and at least one lac operator (lacO) within the sequence of said promoter; and a lad gene encoding a lac repressor protein (LacI) comprising a coding sequence, a lacI promoter operably linked to the lad coding sequence, wherein the lacI promoter is a wild-type lacI promoter or a lacI promoter which increases LacI expression; wherein the expression rate of the POI is regulated by an inducer binding LacI. | 2022-02-17 |
20220049261 | Novel Cell-Based Assay for Determining Activity in the Retinoblastoma Pathway - Disclosed are methods of determining activity of CDK4 and CDK6 variants upon exposure to CDK inhibitors, methods for determining activity of a Rb variant, methods for determining the activity of a p16 variant in a cell, and methods for determining the sensitivity of a CDK4 variant or a CDK6 variant to p16 in a cell. Stable cell lines for determining activity of CDK4 variants, CDK6 variants, Rb variants, and p16 variants are also disclosed. | 2022-02-17 |
20220049262 | RECOMBINANT ACID-RESISTANT YEAST WITH INHIBITED LACTATE METABOLISM AND ALCOHOL PRODUCTION AND METHOD OF PRODUCING LACTIC ACID USING THE SAME - Disclosed is a method of producing lactic acid using a recombinant acid-resistant yeast with inhibited lactate metabolism and alcohol production. More specifically, disclosed are a recombinant acid-resistant yeast in which lactate consumption reaction is reduced and which is imparted with lactic-acid-producing ability to thereby exhibit improved lactic-acid-producing ability and reduced ethanol production, and a method of producing lactic acid using the same. | 2022-02-17 |
20220049263 | VIRUS-BASED REPLICON FOR PLANT GENOME EDITING WITHOUT INSERTING REPLICON INTO PLANT GENOME AND USES THEREOF - A recombinant vector according to an embodiment is for genome editing without inserting a replicon into the plant genome in a T | 2022-02-17 |
20220049264 | ISOLATED POLYNUCLEOTIDES AND POLYPEPTIDES, AND METHODS OF USING SAME FOR INCREASING YIELD OF PLANTS - Provided are isolated polynucleotides and nucleic acid constructs which comprise a nucleic acid sequence at least 80% identical to a nucleic acid sequence selected form the group consisting of SEQ ID NOs: 1-219, 367-5628, 9688-9700, and 9709-9752; and isolated polypeptides which comprise an amino acid sequence at least 80% homologous to an amino acid sequence selected from the group consisting of SEQ ID NOs: 220-366, 5629-9400, 9701-9708, and 9753-9796. Also provided are transgenic cells and plants expressing same and methods of using same for increasing yield, growth rate, biomass, vigor, oil content, seed yield, fiber yield, fiber quality, nitrogen use efficiency, and/or abiotic stress of a plant. | 2022-02-17 |
20220049265 | PLANTS WITH IMPROVED DIGESTIBILITY AND MARKER HAPLOTYPES - The present invention relates to plants, such as maize, | 2022-02-17 |
20220049266 | TOBACCO PLANTS EXHIBITING ALTERED PHOTOSYNTHESIS AND METHODS OF MAKING AND USING - This disclosure provides tobacco plants that exhibit altered photosynthesis as well as methods of making and using such plants. | 2022-02-17 |
20220049267 | NUCLEOTIDE SEQUENCES AND POLYPEPTIDES ENCODED THEREBY USEFUL FOR MODIFYING PLANT CHARACTERISTICS - Isolated polynucleotides and polypeptides encoded thereby are described, together with the use of those products for making transgenic plants with increased tolerance to abiotic stress (e.g., high or low temperature, drought, flood). | 2022-02-17 |
20220049268 | CORN TRANSGENIC EVENT MON 95379 AND METHODS FOR DETECTION AND USES THEREOF - The invention provides a transgenic corn event MON 95379, plants, plant cells, seeds, plant parts, progeny plants, and commodity products comprising event MON 95379. The invention also provides polynucleotides specific for event MON 95379 and methods for using and detecting event MON 95379 as well as plants, plant cells, seeds, plant pails, progeny plants, and commodity products comprising event MON 95379. | 2022-02-17 |
20220049269 | COMPOSITIONS AND METHODS FOR THE IN SITU DELIVERY OF THERAPEUTIC AND DIAGNOSTIC AGENTS - Synthetic minimal cells (SMC) are provided for delivering a therapeutic or diagnostic agent to a subject or to a site within a subject in need of treatment or diagnosis. SMCs may be targeted to the site or sense the site and initiate production and release of the therapeutic or diagnostic agent. SMCs comprise a sensor, at least one genetic circuit and outputting means to deliver the therapeutic agent. | 2022-02-17 |
20220049270 | TRANSGENE CASSETTES, AAV VECTORS, AND AAV VIRAL VECTORS FOR EXPRESSION OF HUMAN CODON-OPTIMIZED CSTB - The present disclosure provides methods and compositions for the treatment of diseases and genetic disorders linked to CSTB loss and/or misfunction. The methods and compositions of the present disclosure include rAAV vectors and rAAV viral vectors comprising transgene nucleic acid molecules encoding CSTB polypeptides. | 2022-02-17 |
20220049271 | ADENOVIRUS VECTORS AND METHODS FOR USING ADENOVIRUS VECTORS - This document provides adenovirus vectors and methods and materials related to using adenovirus vectors. For example, adenoviruses for delivering nucleic acid encoding one or more immunogens (e.g., one or more immunogens associated with a pathogen causing an infection) to cells within a mammal such that the mammal produces an effective immune response against the immunogen(s) are provided. | 2022-02-17 |
20220049272 | GENE THERAPY FOR JUVENILE BATTEN DISEASE - Compositions and methods for the treatment of Juvenile Neuronal Ceroid Lipofuscinosis (JNCL), also known as Juvenile Batten Disease, are provided herein. In certain embodiments the compositions include but are not limited to adeno-associated viral (AAV) constructs, including self-complementary adeno-associated viral (sc-AAV) constructs, that express the human gene CLN3 (or a CLN3 cDNA). | 2022-02-17 |
20220049273 | NOVEL CRISPR DNA TARGETING ENZYMES AND SYSTEMS - The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered CRISPR-Cas systems, components, and methods for targeted modification of nucleic acids such as DNA. Each system includes one or more protein components and one or more nucleic acid components that together target nucleic acids. | 2022-02-17 |
20220049274 | COMPOSITION FOR INDUCING DEATH OF CELLS HAVING MUTATED GENE, AND METHOD FOR INDUCING DEATH OF CELLS HAVING MUTATED GENE BY USING COMPOSITION - The present invention relates to a composition for inducing death of cells having genomic sequence variations, comprising a nuclease and a cleavaging agent, and a method of inducing death of cells having genomic sequence variations. | 2022-02-17 |
20220049275 | SSI CELLS WITH PREDICTABLE AND STABLE TRANSGENE EXPRESSION AND METHODS OF FORMATION - Mammalian cells are described that includes a recombination target site integrated within high integrating locus. Recombinant protein producer cell lines incorporating the mammalian cells and methods for forming the mammalian cells are also described. The high integrating loci have been developed through understanding and mapping of the three dimensional hierarchical structure of chromatin in mammalian cells. The high integrating loci are present in transcriptionally active environments that can provide both chromatin accessibility and epigenetic stability. As such, the recombinant mammalian cells can provide predictable and stable transgene production. | 2022-02-17 |
20220049276 | METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION - The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms. | 2022-02-17 |
20220049277 | Metallic Nanoparticles and Methods of Making and Using the Same - The invention relates to metallic nanoparticles made by that have been made in a plant cell suspension, and methods of making the metallic particles. | 2022-02-17 |
20220049278 | METHOD FOR PRODUCING ETHANOL FROM LIGNOCELLULOSIC RAW MATERIAL - The present invention provides a method for efficiently producing ethanol from a lignocellulosic raw material. More specifically, the present invention provides a method for producing ethanol from a lignocellulosic raw material, which comprises a step of performing multiple parallel fermentation while continuously or intermittently adding an additional saccharification enzyme to a fermentation liquid comprising a lignocellulosic raw material, a saccharification enzyme and a yeast so that the physical property value of the fermentation liquid itself is maintained within a preset range. | 2022-02-17 |
20220049279 | MALONIC SEMI-ALDEHYDE-PRODUCING YEASTS - The present invention relates to a recombinant yeast, in the genome of which at least one nucleic acid encoding an enzyme able to catalyze the decarboxylation of oxaloacetate into malonic semi-aldehyde, or one of its salts is overexpressed and/or under the control of a strong or inducible promoter. The invention also relates to such an enzyme per se, as well as to a method for producing malonic semi-aldehyde, one of its salts, or a malonic semi-aldehyde derivative comprising implementing the said recombinant yeast and to the use of the said recombinant yeast for the production of malonic semi-aldehyde, one of its salts, or a malonic semi-aldehyde derivative. | 2022-02-17 |
20220049280 | METHOD FOR PROMOTING N-ACETYLGLUCOSAMINE SYNTHESIS BY USING GLCN6P RESPONSIVE ELEMENT - The present invention provides a method for promoting N-acetylglucosamine synthesis by using the GlcN6P responsive element. In the present invention, | 2022-02-17 |
20220049281 | DIAGNOSIS AND TREATMENT OF INVASIVE ASPERGILLOSIS - Methods for diagnosing, treating, and monitoring the treatment of invasive aspergillosis (IA) are described. The methods can include detecting the presence of one or more volatile organic compounds (VOCs) in the breath of subjects suspected of having IA. | 2022-02-17 |
20220049282 | Methods for Discovery of Antimicrobial Compounds - Methods are provided for inducing expression of cryptic genes in microbial cells. Microbial cells of a strain derived from a natural environment but grown in a laboratory culture, and having cryptic genes not expressed in the laboratory culture, are placed into a culture chamber having at least one nanoporous membrane. The culture chamber is then placed into a natural environment similar to the environment from which the strain was originally obtained. In the natural environment, the microbial cells are isolated in the culture chamber and exposed to inducers that diffuse into the culture chamber via the nanoporous membrane, and expression of the cryptic gene is induced. | 2022-02-17 |
20220049283 | Method of detecting SARS-CoV-2 cleavage targeted proprotein convertase and facilitated protease activity - The present invention provides the methods of detecting the cleavage activity of PCs and proteases that are in purified form or from a biological sample and target to SARS-CoV-2 spike protein cleavage. | 2022-02-17 |
20220049284 | METHOD OF DETECTING OR METHOD OF QUANTIFYING OLIGONUCLEOTIDES - The present invention provides a method of detecting and a method of quantifying oligonucleotides with more excellent specificity and quantitativity as compared to conventional signal amplification (PALSAR) measurement methods. | 2022-02-17 |
20220049285 | SINGLE CELL/EXOSOME/VESICLE PROTEIN PROFILING - The present disclosure is directed, at least in part, to methods and systems for quantifying the levels of multiple, e.g., over a hundred or more, target molecules, e.g., proteins, in, or on the surface of, single entities, including single exosomes, single cells or single vesicles. | 2022-02-17 |
20220049286 | METHODS OF IDENTIFYING MULTIPLE EPITOPES IN CELLS - The invention provides methods, compositions, kits and devices for the detection of target molecules. In some embodiments, the invention allows for multiplexed target molecule detection. | 2022-02-17 |
20220049287 | Colorimetric sensing polymerase chain reaction (PCR) - Methods are provided here for an easy and reliable non-fluorescent approach to detecting and monitoring PCR amplification. This includes monitoring PCR amplification by using magnesium-sensitive colorimetric dye. The dye is visually detectable color dye. Compositions are described here that comprise a magnesium-sensitive colorimetric dye, a buffer, dNTPs, magnesium ion and DNA polymerase. | 2022-02-17 |
20220049288 | METHODS FOR ESTIMATING CLUSTER NUMBERS - The present invention relates to methods of imaging template hybridisation for estimating cluster numbers prior to solid phase amplification and sequencing. More particularly, an initial round of imaging is carried out at the single molecule template hybridisation stage which allows a general estimation of cluster numbers prior to clusters being formed. Amplification of the signal allows single molecule imaging to be carried out using standard sequencing imaging apparatus. | 2022-02-17 |
20220049289 | CHEMICALLY-ENHANCED PRIMER COMPOSITIONS, METHODS AND KITS - A chemically-enhanced primer is provided comprising a negatively charged moiety (NCM), an oligonucleotide sequence having a) non-nuclease resistant inter-nucleotide linkages or b) at least one nuclease resistance inter-nucleotide linkage. The chemically-enhanced primer can be used for sequencing and fragment analysis. Methods for synthesizing the chemically-enhanced primer as well as a method of preparing DNA for sequencing, a method of sequencing DNA, and kits containing the chemically-enhanced primer are also provided. The method of sequencing DNA can comprise contacting amplification reaction products with the composition wherein excess amplification primer is degraded by the nuclease and the chemically-enhanced primer is essentially non-degraded. | 2022-02-17 |
20220049290 | SYSTEMS AND METHODS TO ASSESS MICROBIOMES AND TREATMENTS THEREOF - Systems and methods to assess the health of various microbiomes and to identity species therein are disclosed. Described assessments and identifications can inform treatment decisions if a microbiome is determined to have a less than optimal balance of bacterial species within it; the presence of one or more negative species; and/or the absence of one or more positive species. | 2022-02-17 |
20220049291 | METHOD AND PRODUCTS FOR PRODUCING FUNCTIONALISED SINGLE STRANDED OLIGONUCLEOTIDES - The present invention relates to functionalized single stranded oligonucleotides and in particular to a method for producing functionalized single stranded oligonucleotides comprising: (a) providing a circular DNA molecule comprising an oligonucleotide sequence bordered by cleavage domains; (b) performing a rolling circle amplification (RCA) reaction with the circular DNA molecule of (a) as a template and one or more functionalized nucleotides (dNTPs); and (c) enzymatically cleaving the product of the RCA reaction at the cleavage domains to release the single stranded functionalized oligonucleotides. | 2022-02-17 |
20220049292 | MULTIPLEXED FLUORESCENT DETECTION OF ANALYTES - In a first aspect, a method includes: providing a sample, the sample including a first nucleotide and a second nucleotide; contacting the sample with a first fluorescent dye and a second fluorescent dye, the first fluorescent dye emitting first emitted light within a first wavelength band responsive to a first excitation illumination light, the second fluorescent dye emitting second emitted light within a second wavelength band responsive to a second excitation illumination light; simultaneously collecting, using one or more image detectors, multiplexed fluorescent light comprising the first emitted light and the second emitted light, the first emitted light being a first color channel corresponding to the first wavelength band and the second emitted light being a second color channel corresponding to the second wavelength band; and identifying the first nucleotide based on the first wavelength band of the first color channel and the second nucleotide based on the second wavelength band of the second color channel. | 2022-02-17 |
20220049293 | METHODS FOR DETERMINING A LOCATION OF A BIOLOGICAL ANALYTE IN A BIOLOGICAL SAMPLE - Provided herein are methods of determining a location of a biological analyte in a biological sample. | 2022-02-17 |
20220049294 | IMAGING SYSTEM HARDWARE - A sample holder includes a first member featuring a first retaining mechanism configured to retain a first substrate that includes a sample, a second member featuring a second retaining mechanism configured to retain a second substrate that includes a reagent medium, and an alignment mechanism connected to at least one of the first and second members, and configured to align the first and second members such that the sample contacts at least a portion of the reagent medium when the first and second members are aligned. | 2022-02-17 |
20220049295 | METHODS OF DIAGNOSING AND TREATING CANCER TARGETING EXTRACHROMOSOMAL DNA - Provided herein are, inter alia, methods and compositions to detect, monitor and treat cancer, wherein the cancer includes amplified extrachromosomal oncogenes. The methods are useful for personalized treatment and exploit differential expression of amplified extrachromosomal oncogenes in cancer cells versus healthy cells. | 2022-02-17 |
20220049296 | NUCLEIC ACID ANALYSIS BY JOINING BARCODED POLYNUCLEOTIDE PROBES - Disclosed are compositions, methods and kits for determining the presence, absence, amount, copy number, or other characteristics of one or more polynucleotide sequences in two or more samples and use thereof in genotyping, evaluation of copy number variation, expression analysis, determination of splice variants and fusion genes, and other genetic analyses. | 2022-02-17 |
20220049297 | METHOD AND KIT FOR DETERMINING GENOME INSTABILITY BASED ON NEXT GENERATION SEQUENCING (NGS) - A method and a kit for determining genome instability based on next generation sequencing (NGS) are disclosed. The new method is used to determine whether there is homologous recombination defect by calculating a comprehensive value of one or more of pathogenic germline and somatic mutations, such as SNV, indels, and CNVs, and Biallelic germline and somatic mutations, pathogenic mutational signature, copy number variation (CNV) in homologous recombination repair (HRR) gene, genomic structural variation and genome instability. The genomics DNA is interrupted and added with an A adapter; then corresponding polymerase chain reaction (PCR) is conducted, and Whole genome sequencing is performed; the hybrid capture is conducted with designed probes of HRR genes and SNPs, and a captured DNA library is subjected to amplification and library sequencing; and then professional bioinformatics software is used for evaluation to determine the homologous recombination deficiency (HRD) status. | 2022-02-17 |
20220049298 | TAGGED-BASE DNA SEQUENCING READOUT ON WAVEGUIDE SURFACES - A method of tagged-base DNA sequencing readout on waveguide surfaces includes immobilizing, a surface of a waveguide, a nucleotide fragment, exposing the nucleotide fragment to a first plurality of capped nucleotides, wherein the first plurality of capped nucleotides include a first plurality of nucleotide types, each distinct nucleotide type has a distinct capping agent, and each distinct capping agent has a distinct optical signature, severing base pair connections between the at least a nucleotide fragment and the first plurality of capped nucleotides, wherein the nucleotide fragment remains attached and a first single nucleotide, of the first plurality of capped nucleotides, remains immobilized on a nucleotide binding locus adjacent to the first nucleotide sequence, and detecting a first distinct optical signature of a first distinct capping agent of the first single nucleotide using the waveguide. | 2022-02-17 |
20220049299 | METHODS AND SYSTEMS FOR DETECTING GENETIC VARIANTS - Disclosed herein in are methods and systems for determining genetic variants (e.g., copy number variation) in a polynucleotide sample. A method for determining copy number variations includes tagging double-stranded polynucleotides with duplex tags, sequencing polynucleotides from the sample and estimating total number of polynucleotides mapping to selected genetic loci. The estimate of total number of polynucleotides can involve estimating the number of double-stranded polynucleotides in the original sample for which no sequence reads are generated. This number can be generated using the number of polynucleotides for which reads for both complementary strands are detected and reads for which only one of the two complementary strands is detected. | 2022-02-17 |
20220049300 | METHODS AND SYSTEMS FOR DETECTING GENETIC VARIANTS - Disclosed herein in are methods and systems for determining genetic variants (e.g., copy number variation) in a polynucleotide sample. A method for determining copy number variations includes tagging double-stranded polynucleotides with duplex tags, sequencing polynucleotides from the sample and estimating total number of polynucleotides mapping to selected genetic loci. The estimate of total number of polynucleotides can involve estimating the number of double-stranded polynucleotides in the original sample for which no sequence reads are generated. This number can be generated using the number of polynucleotides for which reads for both complementary strands are detected and reads for which only one of the two complementary strands is detected. | 2022-02-17 |
20220049301 | BIOMARKERS FOR USE IN INTEGRIN THERAPY APPLICATIONS - The present invention relates to biomarkers for use in determining the sensitivity of patients to therapy with αvβ6 integrin inhibition or therapy with TGF-β pathway inhibitors. The biomarker profiles disclosed herein provide individualized gene and protein profiles which will aid in treating diseases and disorders which are amenable to treatment with therapies designed against αvβ6-integrin and/or TGF-β pathway inhibitors. | 2022-02-17 |
20220049302 | MULTICOMPONENT NUCLEIC ACID PROBES FOR SAMPLE ANALYSIS - The present disclosure provides methods, systems, compositions, and kits for analyzing target molecules, including using probes comprising a plurality of components for analyzing target molecules in situ in a sample. | 2022-02-17 |
20220049303 | METHODS AND SYSTEMS FOR SPATIAL MAPPING OF GENETIC VARIANTS - The present disclosure provides methods and systems for determining the location and identity of variant sequences. The present disclosure also provides methods of treating diseases and of using spatial information of variant sequences in a biological sample to guide treatment selection in a corresponding subject. | 2022-02-17 |
20220049304 | DNA METHYLATION BIOMARKERS OF POST-PARTUM DEPRESSION RISK - The present invention relates to the field of post-partum depression. More specifically, the present invention relates to the use of biomarkers to diagnose post-partum depression or predict a risk thereof. In a specific embodiment, a method for identifying a likelihood of PPD in a patient comprises the steps of (a) providing a sample from the patient; (b) measuring white blood cell type counts and DNA methylation levels of a panel of biomarkers in the sample collected from the patient, wherein the panel of biomarkers comprises HP1BP3 and TTC9B and the white blood cell type counts comprise monocytes and non-monocytes; and (c) identifying the patient as likely to develop PPD based on the relative DNA methylation levels at the biomarker loci relative to the ratio of monocytes:non-monocytes. | 2022-02-17 |
20220049305 | SYSTEMS AND METHODS FOR DETECTION OF DELIRIUM RISK USING EPIGENETIC MARKERS - Disclosed is a method of determining a subject's susceptibility to by collecting a biological sample from the subject; determining the methylation status of at least one CpG sequence in the biological sample from the subject; and comparing the methylation status in the biological sample to an established threshold and determining whether or not the subject is likely to suffer delirium. | 2022-02-17 |
20220049306 | CARDIOVASCULAR DISEASE - The invention relates to a method for the reclassification of a subject to a more appropriate risk assessment to that obtained using the algorithms for such risk estimation such us but not limited to Framingham, Regicor, Score, Procamor Qrisk based on the presence of different polymorphisms. The invention also relates to a method for determining the risk of suffering a cardiovascular disease by combining the absence or presence of one or more polymorphic markers in a sample from the subject with conventional risk factors for CVD as well as computer-implemented means for carrying out said method. | 2022-02-17 |
20220049307 | MITOCHONDRIAL MARKERS OF NEURODEGENERATIVE DISEASES - The present invention relates to an in vitro method to diagnose or determine the risk of developing a neurodegenerative disease in a subject based on the determination of the methylation pattern in certain regions of mitochondrial DNA from said subject or determining the nucleotide at the polymorphic position 16519 in the mitochondrial DNA of said subject. Finally, the present invention relates to nucleic acids suitable for application of the invention. | 2022-02-17 |
20220049308 | Treatment Of Obesity In Subjects Having Variant Nucleic Acid Molecules Encoding Calcitonin Receptor (CALCR) - The present disclosure provides methods of treating subjects having obesity and/or increased body mass index (BMI), and methods of identifying subjects having an increased risk of developing obesity and/or BMI. | 2022-02-17 |
20220049309 | MARKERS OF DISEASE PROGNOSIS IN MULTIPLE SCLEROSIS - Provided are methods and kits for early determination of disease outcome and prognosis of Multiple Sclerosis (MS) patients and for adjustment of suitable treatment. | 2022-02-17 |
20220049310 | Use of ZNF124 Gene in Early Screening or Auxiliary Diagnosis of Retinitis Pigmentosa Disease - The present disclosure discloses a use of a ZNF124 gene in early screening or auxiliary diagnosis of retinitis pigmentosa disease. The present disclosure also discloses a use of a detection reagent for detecting ZNF124 gene mutation in preparation of a reagent or a kit for early screening or auxiliary diagnosis of the retinitis pigmentosa disease. Research of the present disclosure finds that the mutation of the ZNF124 gene is related to the retinitis pigmentosa disease, early screening or auxiliary diagnosis can be performed on the retinitis pigmentosa disease by detecting the mutation of the ZNF124 gene. | 2022-02-17 |
20220049311 | CHROMATIN MAPPING ASSAYS AND KITS USING LONG-READ SEQUENCING - This present invention relates to methods for carrying out chromatin mapping assays that use enzymes to incorporate barcoded DNA at targeted genomic regions followed by long-read sequencing (e.g., Third Generation Sequencing (TGS)). This approach enables the mapping of chromatin targets using TGS and can be used for a wide range of elements or features, including histone post-translational modifications, chromatin associated proteins, nucleosome positioning, and chromatin accessibility. The invention further relates to kits and reagents for carrying out the methods on chromatin samples that include one or more cells. | 2022-02-17 |
20220049312 | microRNAs as Biomarkers for Endometriosis - Disclosed herein are compositions and methods useful for the diagnosis, assessment, and characterization of endometriosis in a subject in need thereof, based upon the expression level of at least one miRNA that is associated with endometriosis. | 2022-02-17 |
20220049313 | PRIMER FOR DETECTING TUMOR MICROSATELLITE INSTABILITY, USE THEREOF AND KIT - In the technical field of molecular diagnosis, a detection primer for detecting tumor microsatellite instability (MSI), use thereof, a kit and method for amplifying tumor microsatellite loci is disclosed. The detection primer includes one or more of microsatellite locus amplification primers selected from sequences shown as SEQ ID NOs: 1 to 26 and can simultaneously amplify a plurality of microsatellite loci in the same PCR system and perform multiplex fluorescent PCR to detect MSI, with no cross peak or overlapped peak among fluorescence peaks generated by electrophoresis of amplified products of microsatellite sites and with high detection efficiency and excellent sensitivity. | 2022-02-17 |
20220049314 | PKS-ISLAND POSITIVE E. COLI AS MARKER OF NEGATIVE RESPONSE TO ANTI-PD1 THERAPY IN COLORECTAL CANCER - A method of predicting resistance to anti-PD1 therapy in a subject suffering from cancer comprising the steps of a) determining, from a biological sample from a subject, in particular a feces or colonic biopsy sample from the subject, the presence of a bacterial pks island, b) predicting from the result of step a) that the subject is likely to be resistant to anti-PD1 therapy, is provided. Methods of treating cancer in a subject by assessing the presence or absence of bacterial pks island in a biological sample from a subject, in particular a feces or colonic biopsy sample from the subject and administering to the subject an anti-cancer therapy are also provided. | 2022-02-17 |
20220049315 | COMPOSITIONS AND METHODS FOR DETECTING AND TREATING HIGH GRADE SUBTYPES OF UTERINE CANCER - The present invention relates to methods and biomarkers for detection and characterization of conditions associated with aberrant function of the PPP2R1A subunit of the PP2A protein (e.g., high grade subtypes of uterine cancer) in biological samples (e.g., tissue samples, blood samples, plasma samples, cell samples, serum samples), and related methods of treatment. In particular, the present invention provides compositions and methods for characterizing a patient as having such a condition by identifying mutations in the PPP2R1A subunit of the PP2A gene or gene products, and related methods of treatment through administering to such a patient a DNA Damage Response Pathway (DDR) modulating agent (e.g., a ribonucleotide reductase inhibitor). | 2022-02-17 |
20220049316 | METHOD FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF BREAST CANCER METASTASIS - The present invention relates to a method for the diagnosis or the prognosis of metastasis in breast cancer which comprises determining if the c-MAF gene is amplified in a primary tumor sample. Likewise, the invention also relates to a method for the diagnosis or the prognosis of metastasis in ER-breast cancer, as well as to a method for determining the tendency to develop bone metastasis with respect to metastasis in other organs, which comprise determining the c-MAF gene expression level. Finally, the invention relates to the use of a c-MAF inhibitor as therapeutic target for treating the ER-breast cancer metastasis. | 2022-02-17 |
20220049317 | IN-VITRO METHOD FOR DIAGNOSIS AND PROGNOSIS OF A DISEASE - The present invention relates an in-vitro method for diagnosis and/or prognosis of a disease in a tissue sample obtained from a mammalian subject comprising (i) Determining the level of a first biomarker using matrix-assisted laser desorption/ionization (MALDI)-imaging in the sample; (ii) Performing a histochemical staining of the sample; (iii) Determining the ratio of the levels of a second biomarker and a reference marker using fluorescence in situ-hybridization (FISH); wherein the same sample is used in steps (i) to (iii). | 2022-02-17 |
20220049318 | METHODS FOR DETECTING SINGLE NUCLEOTIDE VARIANTS OR INDELS BY DEEP SEQUENCING - Disclosed herein are methods for use in detection of single nucleotide variants (SNVs) or indels. The methods may comprise enriching cell-free DNA molecules for a panel of genomic regions and deep sequencing the enriched cfDNA to detect the SNVs or indels. | 2022-02-17 |
20220049319 | METHODS FOR DETECTING AND TREATING PROPRANOLOL SENSITIVE TUMORS - The present disclosure relates to methods for detecting and treating propranolol sensitive tumors. | 2022-02-17 |
20220049320 | METHOD FOR THE CYTOLOGICAL ANALYSIS OF CERVICAL CELLS - The invention provides for a diagnostic test to monitor cancer-specific genetic abnormalities to diagnose cervical cell disorders and predict which patients might progress to cancer. Genetic abnormalities are detected by identification in chromosomal copy number of chromosome 3 and chromosome 5 using FISH analysis of probes targeted to 3q and/or 5p. | 2022-02-17 |
20220049321 | METHOD, SYSTEM AND APPARATUS FOR BLOOD PROCESSING UNIT - The disclosed embodiments may be used, among others, to extract particles from blood. The particles may include pathogens, viruses, bacteria and other microorganisms present in mammalian blood. An embodiment of the disclosure relates to a system to detect one or more blood-borne pathogens. The exemplary system includes: a transfer assembly having a tube and a hallow needle, the hallow needle centrally located within the transfer assembly tube and configured to communicate a sample material therethrough; a lysing syringe to couple to the transfer assembly, the lysing syringe comprising one or more lysing reagent and a plunger activatable to receive the sample material through the transfer assembly; and a large volume concentrator (LVC) to sealingly couple to the lysing syringe and to separate at least one pathogen from the sample material, the LVC further comprising: a filter support, a membrane, a retainer and a threaded portion. | 2022-02-17 |
20220049322 | NON-DIRECTIONAL ELECTRICAL STEEL SHEET AND METHOD FOR PRODUCING SAME - A non-oriented electrical steel sheet according to an embodiment of the present invention includes, in wt %, Si at 0.2 to 4.3%, Mn at 0.05 to 2.5%, Al at 0.1 to 2.1%, Bi at 0.0001 to 0.003%, Ga at 0.0001 to 0.003%, and the balance of Fe and inevitable impurities. | 2022-02-17 |
20220049323 | NON-ORIENTED ELECTRICAL STEEL SHEET - Proposed is a non-oriented electrical steel sheet being low in iron loss and excellent in tensile strength and fatigue strength, which has a chemical composition comprising C: not more than 0.005 mass %, Si: 3 to 5 mass %, Mn: not more than 5 mass %, P: not more than 0.1 mass %, S: not more than 0.01 mass %, Al: not more than 3 mass %, N: not more than 0.005 mass %, Zn: 0.0005 mass % to 0.003 mass %, and the remainder being Fe and inevitable impurities, an average crystal grain size being not more than 40 μm, the number of the inclusions having a diameter of not less than 5 μm being not more than 5/mm | 2022-02-17 |
20220049324 | METHOD FOR MANUFACTURING STEEL SHEET FOR COLD PRESS AND METHOD FOR MANUFACTURING PRESS COMPONENT - A method that improves stretch flange formability of a steel sheet by individual treatment matching a material of the steel sheet without performing heat treatment in a die. This method is a method for manufacturing a steel sheet for cold press, and the steel sheet is manufactured by heating an edge of the steel sheet to a temperature within a heating temperature range preset according to a microstructure of the steel sheet and cooling the steel sheet. A region, within an edge of the steel sheet subjected to shearing in a shearing step, where it is estimated that a stretch flange crack is likely to occur when a press component is formed by cold pressing is determined, and a site to be heated and cooled is set within the region. By press-forming the manufactured steel sheet, a target press component is manufactured. | 2022-02-17 |
20220049325 | METHOD FOR PROTECTION AGAINST FRETTING FATIGUE BY COMPOUND MODIFICATION VIA LASER SHOCK PEENING AND COATING LUBRICATION - The present disclosure provides a method for protection against fretting fatigue by compound modification via laser shock peening and coating lubrication, where a group of micro-pits distributed into a regular array is firstly formed in a surface of a metal material by using laser shock peening, with a single micro-pit having a diameter of 1 to 10 mm and a depth of 1 to 20 μm; and the micro-pits are then coated with a lubricant by coating preparation. Based on the micro-pit styling feature and surface residual compressive stress introducing feature of the laser shock peening, with compound modification by surface texturing via the laser shock peening and coating lubrication, the surface of the material can be reinforced by residual compressive stress, coating lubrication and surface micro-pit texturing with a synergistic effect, thus allowing for improved fretting fatigue behavior of the material. | 2022-02-17 |
20220049326 | NICKEL-BASED SUPERALLOY AND PARTS MADE FROM SAID SUPERALLOY - A nickel superalloy has the following composition, the concentrations of the different elements being expressed as wt-%: Formula (I), the remainder consisting of nickel and impurities resulting from the production of the superalloy. In addition, the composition satisfies the following equation, wherein the concentrations of the different elements are expressed as atomic percent: Formula (II). | 2022-02-17 |
20220049327 | CORRODIBLE DOWNHOLE ARTICLE - This invention relates to a corrodible downhole article comprising an aluminium alloy, wherein the aluminium alloy comprises (a) 3-15 wt % Mg, (b) 0.01-5 wt % In, (c) 0-0.25 wt % Ga, and (d) at least 60 wt % Al. The invention also relates to a method of making a corrodible downhole article comprising an aluminium alloy, the method comprising the steps of: (a) melting aluminium, Mg, In, optionally Ga, and Ni, to form a molten aluminium alloy comprising 3-15 wt % Mg, 0.01-5 wt % In, 0-0.25 wt % Ga, and at least 60 wt % Al, (b) mixing the resulting molten aluminium alloy, (c) casting the aluminium alloy or producing an aluminium alloy powder, and (d) forming the aluminium alloy into a corrodible downhole article. In addition, the invention relates to a method of hydraulic fracturing comprising the use of the corrodible downhole article. | 2022-02-17 |
20220049328 | MECHANICALLY ALLOYED LI-SN-ZN - A product includes a ternary alloy consisting essentially of Sn | 2022-02-17 |
20220049329 | ALLOY COMPOSITION, METHOD FOR PRODUCING ALLOY COMPOSITION, AND DIE - An object is to provide an alloy composition that has a sufficient melting point for casting of an aluminum alloy, also has high hardness, and can suppress an occurrence of galling. The alloy composition of the present invention includes: a Mo—Cr-based dendritic structure | 2022-02-17 |
20220049330 | SPOT WELDED MEMBER - A spot welded member includes a spot weld formed by holding a sheet stack of multiple steel sheets between a pair of electrodes and spot-welding the sheet stack, in which at least one of the multiple steel sheets is a high-strength zinc-based coated steel sheet having a tensile strength of 780 MPa or more, the high-strength zinc-based coated steel sheet having a coating with an Al content of 0.5% or more by mass, and in which the heat shock region of the spot weld outwardly extending from an edge of a corona bond area includes a coated layer including an FeAl alloy layer having an average thickness of 0.3 μm or more and a zinc-based coated layer having an average thickness of 2.0 μm or more on the FeAl alloy layer at the interface between the base steel sheet of the high-strength zinc-based coated steel sheet and the coating. | 2022-02-17 |
20220049331 | LONG DURABILITY HIGH PERFORMANCE STEEL FOR STRUCTURAL, MACHINE AND TOOLING APPLICATIONS - Steels, in particular hot work steels having high toughness even for high thickness, including steels having long durability combined with mechanical, tribological and thermal properties for highly demanding applications, and steels which can achieve a very good environmental resistance and resistance to certain aggressive media combined with other relevant properties, are described. These steels may also be obtained at low cost. A method for the manufacture of steels having high thickness and manufacturing methods to shape the materials of the invention through several steps, including an additive manufacturing step to manufacture at least apart of an intermediate mold, a mold or a model, a Cold Isostatic Pressing (CIP) step, the elimination of the mold and densification among other steps, are also described. | 2022-02-17 |
20220049332 | LOW THERMAL EXPANSION ALLOY HAVING EXCELLENT LOW TEMPERATURE STABILITY AND METHOD FOR PRODUCING SAME - Provided is a low thermal expansion alloy that contains, in mass %, not more than 0.015% of C, not more than 0.10% of Si, not more than 0.15% of Mn, 35.0-37.0% of Ni, and less than 2.0% of Co. Ni+0.8Co is 35.0-37.0%, and the remaining portion is Fe and unavoidable impurities. The low thermal expansion alloy has a solidification structure in which the secondary dendrite-arm spacing is 5 μm or less, has an average thermal expansion coefficient in a range of 0±0.2 ppm/° C. at 100° C. to −70° C., and has an Ms point of −196° C. or less. | 2022-02-17 |
20220049333 | AUSTENITIC STAINLESS STEEL HAVING EXCELLENT PIPE-EXPANDABILITY AND AGE CRACKING RESISTANCE - The austenitic stainless steel that does not cause defects such as aging crack or delayed fracture even after the expansion and curling process of 5 steps or more is disclosed. In accordance with an aspect of the present disclosure, an austenitic stainless steel with excellent pipe expanding workability and aging crack resistance includes, in percent (%) by weight of the entire composition, C: 0.01 to 0.04%, Si: 0.1 to 1.0%, Mn: 0.1 to 2.0%, Cr: 16 to 20%, Ni: 6 to 10%, Cu: 0.1 to 2.0%, Mo: 0.2% or less, N: 0.035 to 0.07%, the remainder of iron (Fe) and other inevitable impurities, and the C+N satisfies 0.1% or less, the product of the Md30 (° C.) value and average grain size (μm) satisfies less than −500. | 2022-02-17 |
20220049334 | PERFORMANCE CONTROLLING METHOD FOR HIGH-STRENGTH ALUMINUM ALLOY SHELL DURING ULTRA-LOW TEMPERATURE FORMING PROCESS - Provided is a performance controlling method for a high-strength aluminum alloy shell during an ultra-low temperature forming process. The present disclosure greatly improves the performance of an aluminum alloy sheet by applying an ultra-low temperature. The present disclosure cools the aluminum alloy sheet to an ultra-low temperature by using an ultra-low temperature cooling medium, so as to compensate for insufficient hardening caused by insufficient deformation and avoid cracking caused by increased deformation. The present disclosure cools the sheet blank zonally according to a deformation law of a desired curved part, and controls the ultra-low temperature distribution of the sheet blank during forming so as to promote the formation of a substructure in a small-deformation zone. In this way, the present disclosure improves a subsequent age-hardening effect, and corresponding uniformity of microstructure and performance, and effectively solves the problem of non-uniformity due to uneven deformation. | 2022-02-17 |
20220049335 | AlMgMn ALLOY PRODUCT WITH IMPROVED CORROSION RESISTANCE - The invention relates to a method for manufacturing an aluminum alloy sheet, wherein an aluminum alloy is prepared with the following composition, in wt %: Mg: 4.0-5.2, Mn: 0.40-1.0, Zn: 0.15-0.40, at least one element selected from Ti, Cr, Cu and Zr, the content of the element, if selected, being 0.01-0.15 for Ti, 0.05-0.25 for Cr, 0.02-0.25 for Cu, 0.05-0.25 for Zr, Fe: <0.40, Si: <0.40, other elements or impurities<0.05 each and<0.15 in total, the remainder being aluminum. A rolling plate is cast by vertical semi-continuous casting, and said optionally homogenised plate is hot-rolled in two successive stages to obtain a sheet. The sheets obtained by the method according to the invention are advantageous, in particular for shipbuilding, since they demonstrate, after being exposed for 7 days to a temperature of 100° C., a weight loss of less than 15 mg/cm2 during a corrosion test according to the ASTM G67 standard. | 2022-02-17 |
20220049336 | NICKEL-COBALT MATERIAL AND METHOD OF FORMING - A nickel-cobalt material and component includes a thermally stabilized nickel-cobalt alloy. The nickel-cobalt alloy disclosed herein includes nanocrystalline grain structures, pinning, such as Zener pinning, and intragranular twinning. The nickel-cobalt alloy disclosed herein exhibits multiple properties including an improved fracture toughness, an increased thermal stability, and an improved ultimate tensile strength. | 2022-02-17 |
20220049337 | STEEL SHEET PLATED WITH AL-FE ALLOY FOR HOT PRESS FORMING HAVING EXCELLENT CORROSION RESISTANCE AND HEAT RESISTANCE, HOT PRESS FORMED PART, AND MANUFACTURING METHOD THEREFOR - The present invention provides a steel plate plated with an aluminum-iron alloy for hot press forming, the steel plate comprising a base steel sheet and an alloy plated layer formed on the base steel sheet, wherein the alloy plated layer comprises: an alloyed layer (I) formed on the base steel sheet and containing, by weight, Al: 5-30%; an alloyed layer (II) formed on the alloyed layer (I) and containing, by weight, Al: 30-60%; and an alloyed layer (III) formed on the alloyed layer (II) and containing, by weight, Al: 20-50%, wherein the alloy layer (II) has a FeAl (Si) alloy phase dispersed and distributed therein, the FeAl(Si) alloy phase comprising, by weight, Al: 20-50% and Si: 5-20%, and the number density of the FeAl(Si) alloy phase having a circle-equivalent diameter of 5 μm or less is 103/mm2 or more. | 2022-02-17 |
20220049338 | ALUMINUM-BASED PLATED STEEL PLATE FOR HOT PRESS HAVING EXCELLENT RESISTANCE AGAINST HYDROGEN DELAYED FRACTURE AND SPOT WELDABILITY, AND METHOD FOR MANUFACTURING SAME - The present invention provides an aluminum-based plated steel plate used in hot-press forming, the steel plate comprising: a base steel plate; and a plating layer formed on the base steel plate, wherein the plating layer comprises: an alloying layer formed on the surface of the base steel plate and including one or more of Fe 3Al, FeAl(Si), Fe 2Al 5, and FeAl 3; and an aluminum layer formed on the alloying layer and having a thickness less than 10% of the thickness of the plating layer, and the plating layer has a thickness of 5-20 μm and an oxygen content of 10 weight % or less, as measured by GDS, at a depth of 0.1 μm from the surface of the plating layer. | 2022-02-17 |
20220049339 | Method and coating device for coating a metal strip - Within a coating device, a metal strip first runs through a coating container with a liquid coating agent and then a stripping nozzle device for stripping off excess coating agent from the surface of the strip. After the stripping nozzle device, the strip runs through a strip stabilizing device with a plurality of magnets on both broad sides of the strip. A form control deviation is determined as the difference between an actual form of the strip and a desired form of the strip and this form control deviation is used for activating the magnets in order to transform the actual form of the strip into the desired form. The magnets of the strip stabilizing device may be moved in the widthwise direction of the strip into a traversing position in relation to the magnets on the respectively opposite broad side of the strip. | 2022-02-17 |
20220049340 | THERMAL SPRAYING METHOD AND APPARATUS FOR PRODUCING ENVIRONMENTAL BARRIER COATINGS - A method includes feeding at least one ceramic feedstock into a heating zone of a thermal spray apparatus to form a heated ceramic feedstock. The heated ceramic feedstock is entrained in a plasma gas to form a heated gas stream directed toward a target surface of a CMC substrate. A sacrificial composition is fed with a sacrificial composition feed apparatus into the heated gas stream downstream of the heating zone at a selected injection angle α of about −30° to about +30° with respect to a plane of the target surface of the substrate. The heated ceramic feedstock is deposited from the heated gas stream onto the target surface to form a coating thereon. The thermal spray apparatus and the sacrificial composition feed system are configured to independently control a chemistry and a porosity of the coating. | 2022-02-17 |
20220049341 | HIGH SURFACE-PRESSURE RESISTANT COMPONENT AND PRODUCTION METHOD THEREFOR - A high surface-pressure resistant component includes a steel having a composition containing, in mass %, 0.17-0.23% of C, 0.80-1.00% of Si, 0.65-1.00% of Mn, 0.030% or less of P, 0.030% or less of S, 0.01-1.00% of Cu, 0.01-3.00% of Ni, and 0.80-1.00% of Cr, with the remainder being Fe and unavoidable impurities, in which the surface layer C concentration of a carburized and quenched layer is 0.70-0.80% in mass %. | 2022-02-17 |
20220049342 | MASK AND FABRICATING METHOD THEREOF, AND DISPLAYING BASE PLATE AND FABRICATING METHOD THEREOF - A mask and a fabricating method thereof, and a displaying base plate and a fabricating method thereof, which relates to the technical field of displaying. The mask includes at least one mask unit, and the at least one mask unit includes an opening region and a main-body region that surrounds the opening region; and the main-body region includes a via-hole unit adjacent to the opening region, and the via-hole unit is configured so that, when the mask is being used on a substrate to form a film-layer pattern, a film-layer material is able to pass through the via-hole unit and deposit within a region of the substrate that corresponds to the opening region. The present disclosure is suitable for the fabrication of masks. | 2022-02-17 |
20220049343 | MASK, METHOD OF PROVIDING MASK, AND METHOD OF PROVIDING DISPLAY PANEL USING THE SAME - A deposition mask includes a mask film including a polymer, a plurality of first deposition openings defined in the mask film. and a conductive layer which is on the mask film and receives a power. The conductive layer includes a first conductive pattern and a second conductive pattern spaced apart from each other along the mask film and electrically disconnected from each other. The conductive layer receives the power at the first conductive pattern and the second conductive pattern, and receipt of the power at the first conductive pattern and the second conductive pattern provides an electrostatic chuck function of the deposition mask. | 2022-02-17 |
20220049344 | High-Frequency-Transparent Component and Method for Producing the Same - The invention relates to a high-frequency-transparent component comprising: a main body ( | 2022-02-17 |
20220049345 | FLUORINE-DOPED OPTICAL MATERIALS FOR OPTICAL COMPONENTS - An optical component includes an optical material which is a fluorine (F)-containing optical material doped with an F-containing species different from the F-containing optical material. A coating system for depositing the optical material onto a substrate or a bulk material of an optical component is an electron beam evaporation coating system, an ion assisted deposition coating system, or an ion beam sputtering coating system. | 2022-02-17 |
20220049346 | Sputtering Target and Method for Producing Same - Provided is a cylindrical sputtering target made of a metal material, which has reduced particles. The sputtering target includes at least a target material, wherein the target material includes one or more metal elements, and has a crystal grain size of 10 μm or less. | 2022-02-17 |
20220049347 | METHOD FOR OPERATING A COATING INSTALLATION FOR PRODUCING LAYER SYSTEMS - A self-controlling feedback method for operating at least one coating installation for producing layer systems, a method for producing a layer system in at least one coating installation, a method for running in a coating process in at least one coating installation for producing a layer system, a coating system for producing a layer system, a coating installation for producing a layer system, a system of coating installations for producing layer systems, a database for storing installation datasets, a computer program product for a method for operating at least one coating installation, and a data processing system for executing a data processing program are disclosed. | 2022-02-17 |