07th week of 2013 patent applcation highlights part 47 |
Patent application number | Title | Published |
20130041130 | TRANSPARENT COPOLYESTER, PREPARING METHOD THEREOF AND ARTICLES MADE FROM THE SAME - The present invention relates to a transparent copolyester, wherein the transparent copolyester comprises an aliphatic-aromatic copolyester segment A, a segment B having repeating units —O—CH(CH | 2013-02-14 |
20130041131 | GLYCOSYLATED SPECIFICITY EXCHANGERS - The present invention is directed to ligand/receptor and antigen/antibody specificity exchangers comprising a saccharide or glycoconjugate. Methods of making these specificity exchangers and methods of using said specificity exchangers to treat or prevent human disease are described herein. | 2013-02-14 |
20130041132 | CHEMICAL PREPARATION OF UBIQUITIN THIOESTERS AND MODIFICATIONS THEREOF - The present invention discloses latent thioester functionalities attached to the C-terminus of a first polypeptide, or a first fragment thereof having a Cys residue at its N-terminus, and a process using this functionality for the preparation of polypeptide thioesters, in particular of ubiquitin thioesters, this process comprising preparing a polypeptide or a fragment thereof, being attached to a latent thioester functionality, which can then be ligated with a second polypeptide fragment, followed by selective activation of the latent thioester functionality group, to provide the requested polypeptide thioester. There are also provided the polypeptides obtained by this method, specific unnatural amino acids useful to be incorporated within the polypeptide thioesters, and kits for preparing them. | 2013-02-14 |
20130041133 | NOVEL SINGLE CHEMICAL ENTITIES AND METHODS FOR DELIVERY OF OLIGONUCLEOTIDES - In an embodiment the instant invention discloses a modular composition comprising 1) an oligonucleotide; 2) one or more linkers, which may be the same or different, selected from Table 1, wherein the linkers are attached to the oligonucleotide at any 3′ and/or 5′ end; 3) one or more peptides, which may be the same or different, selected from SEQ ID NOs: 1-59, wherein the peptides are attached to the linkers; and optionally one or more lipids, solubilizing groups and/or targeting ligands attached to the oligonucleotide. | 2013-02-14 |
20130041134 | METHODS FOR PREPARING POLYETHYLENE GLYCOL MALEIMIDE USING N-(2-HYDROXYETHYL) MALEIMIDE AS A STARTING MATERIAL - The present invention relates generally to methods for preparing polyethylene glycol maleimide (“PEG-Mal”). More specifically, the present invention relates to methods for synthesizing desired molecular weight PEG-Mal by direct ethoxylation of N-(2-hydroxyethyl)maleimide under specific reaction conditions. | 2013-02-14 |
20130041135 | FILLER FOR AFFINITY CHROMATOGRAPHY AND METHOD FOR ISOLATING IMMUNOGLOBULIN - Provided are a filler for affinity chromatography which has excellent alkali resistance, and a method for isolating immunoglobulin. The filler for affinity chromatography is a filler in which a protein represented by the following formula (1) is immobilized on a carrier. | 2013-02-14 |
20130041136 | LIGANDS THAT HAVE BINDING SPECIFICITY FOR EGFR AND/OR VEGF AND METHODS OF USE THEREFOR - Disclosed are ligands that have binding specificity for vascular endothelial growth factor (VEGF), for epidermal growth factor receptor (EGFR), or for VEGF and EGFR. Also disclosed are methods of using these ligands. In particular, the use of these ligands for cancer therapy is described. | 2013-02-14 |
20130041137 | von Willebrand Factor (vWF) - Cleaving Protease - This invention is intended to isolate and identify a vWF-specific cleaving protease. The vWF-specific cleaving protease cleaves a bond between residues Tyr 842 and Met 843 of vWF and comprises a polypeptide chain having Leu-Leu-Val-Ala-Val (SEQ ID NO: 1) as a partial sequence, and more preferably comprises a polypeptide chain having the partial N-terminal amino acid sequence of a mature protein, Ala-Ala-Gly-Gly-Ile-Leu-His-Leu-Glu-Leu-Leu-Val-Ala-Val (SEQ ID NO: 2), and having a molecular weight of 105 to 160 kDa in SDS-PAGE under reducing or non-reducing conditions. Isolation and identification of this vWF-specific cleaving protease have led to the possibility of replacement therapy for patients having diseases resulting from a deficiency of the protease, such as thrombotic thrombocytopenic purpura. | 2013-02-14 |
20130041138 | ANTIBODIES THAT BIND TO PSCA PROTEINS FOR DIAGNOSIS OF CANCER - Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization. | 2013-02-14 |
20130041139 | ENHANCED PROTEIN PURIFICATION THROUGH A MODIFIED PROTEIN A ELUTION - The present invention provides methods for purifying a polypeptide comprising a CH2/CH3 region, comprising binding the polypeptide to Protein A and eluting with a pH gradient starting at a low pH. | 2013-02-14 |
20130041140 | Preparation and/or Purification of Oligonucleotide Conjugates - Methods, systems and/or kits for the preparation, purification and isolation of oligonucleotide conjugates, comprising conjugation of modified antibodies or proteins with at least one modified oligonucleotide at greater than 80% efficiency to form oligonucleotide conjugates and isolating the oligonucleotide conjugates from the conjugation solution by binding the conjugates to an immobilized binder, wherein the binder may be a metal ion or an antibody. | 2013-02-14 |
20130041141 | FLUORESCENT POLYMER COMPOSITION - This invention relates to a detection system for measuring a fluorescent signal in a fluorescent assay. The system comprises a probe having a small sensing surface bound with a fluorescent label, and a light source and a detector both mounted at the proximal side of the sensing surface of the substrate. The invention also relates to a method for detecting an analyte in a liquid sample using a probe tip having a small surface area (≦5 mm) and a high molecular weight polymer (≧1 MD) having multiple binding molecules and multiple fluorescent labels. The binding reaction is accelerated by flowing the reaction solutions laterally and moving the probe tip up and down in the reaction vessels. The invention furthers relates to a fluorescent labeling composition comprising a cross-linked FICOLL® molecule having a plurality of binding molecules and a plurality of fluorescent labels. | 2013-02-14 |
20130041142 | HUMAN SWEET TASTE RECEPTOR-ACTING SWEET TASTE REGULATING SUBSTANCE TO SWEET TASTE SUBSTANCE - [Object] An object of the present invention is to provide a human sweet taste receptor-acting sweet taste regulating substance to a sweet taste substance by which the advantageous effects such as improvement in a taste, saving of a sweetener, reduction in calorie, low caries etc. can be obtained by applying to various foods and beverages. | 2013-02-14 |
20130041143 | POLYNUCLEOTIDES ENCODING ANTIBODIES TO CYTOKINE RECEPTOR ZCYTOR17 - Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto. | 2013-02-14 |
20130041144 | 5'-SUBSTITUTED BICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM - Provided herein are novel 5′-(S)—CH | 2013-02-14 |
20130041145 | METHOD FOR ISOLATING RNA FROM WHOLE BLOOD SAMPLES - The present invention relates to a method for isolating RNA from a whole blood sample, comprising the steps bringing the sample into contact with an aqueous lysis solution containing at least one lysis substance in a concentration of 1.5 mol/1 to 7 mol/1 and at least one detergent, simultaneously or subsequently adding a proteinase, in particular proteinase K, then incubating the solution for at least partial enzymatic digestion and lysis of the sample so that a lysate is obtained, and isolating the RNA from the lysate. | 2013-02-14 |
20130041146 | Asymmetric Catalytic Reduction of Oxcarbazepine - A process for preparing (S)-(+)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide or (R)-(−)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide, by reduction of oxcarbazepine in the presence of a catalyst and a hydride source is disclosed. The catalyst is prepared from a combination of [RuX | 2013-02-14 |
20130041147 | Process for preparing 2-(aminomethylidene)-4,4-difluoro-3-oxobutyric esters - The present invention relates to a process for preparing difluoromethyl-substituted pyrazol-4-ylcarboxylic acids and their esters, 2-(aminomethylidene)-4,4-difluoro-3- oxobutteric esters of the formula (I) | 2013-02-14 |
20130041148 | PROCESS FOR THE SYNTHESIS OF N-ALKOXYAMINES - The present invention relates to novel processes for the preparation of sterically hindered amine ethers by the transformation of a corresponding oxo-piperidin to a hydroxy or amino substituted sterically hindered amine ether and the preparation of a N-propoxy or N-propenoxy substituted sterically hindered amine and some novel compounds obtainable by these processes. The compounds made by these processes are particularly effective in the stabilization of polymer compositions against harmful effects of light, oxygen and/or heat and as flame-retardants for polymers. | 2013-02-14 |
20130041149 | New Method for Synthesizing Imatinib - In the present invention, a synthesis method of Imatinib is disclosed, which comprises the following steps: the Imatinib, namely 4-(4-methyl-piperazin-1-ylmethyl)-N-[4-methyl-3-[4-(3-pyridinyl)-pyrimidin-2-ylamino]-benzamide shown in formula (III), is formed by reacting 4-methyl-N-3-(4-pyridin-3-yl-pyrimidin-2-yl)-1,3-benzenediamine shown in formula (I) with 4-(4-methyl-piperazin-1-methyl)-benzoic ester shown in formula (II), under the action of a base and in a non-protonic organic solvent, | 2013-02-14 |
20130041150 | PROCESS FOR THE PREPARATION OF CHIRAL BETA AMINO CARBOXAMIDE DERIVATIVES - The present invention provides a process for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof, having the R-configuration, of formula (IA), or S-configuration of formula (IB), selectively over the other enantiomer. | 2013-02-14 |
20130041151 | RUTHENIUM COMPLEX AND METHOD FOR PREPARING OPTICALLY ACTIVE ALCOHOL COMPOUND - The present invention provides a novel ruthenium complex which has an excellent catalytic activity in terms of reactivity for asymmetric reduction of a carbonyl compound and enantioselectivity, a catalyst using the ruthenium complex, and a method for preparing optically active alcohol compounds using the ruthenium complex. The present invention relates to a ruthenium complex having ruthenacycle structure, a catalyst for asymmetric reduction consisting of the ruthenium complex, and a method for preparing optically active alcohol using the ruthenium complex. | 2013-02-14 |
20130041152 | 6-HETEROCYCLIC IMIDAZO[1,2-a]PYRIDINE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF - Compounds of formula (I): | 2013-02-14 |
20130041153 | DERIVATIVES HAVING VINYL GROUP AND ITS USE IN ELECTROLUMINESCENT ELEMENT - The present invention relates to imidazole derivatives having vinyl group represented by general formula (I) which possess electron transporting character, have a high glass transition temperature (T | 2013-02-14 |
20130041154 | PROCESS FOR PRODUCING CISATRACURIUM AND ASSOCIATED INTERMEDIATES - The present invention provides a process of producing cisatracurium compounds, e.g., cisatracurium besylate, from isoquinolinium salts of the structural formula (VIIA) wherein X | 2013-02-14 |
20130041155 | CARBON NANORING, METHOD FOR PRODUCING SAME, COMPOUND SUITABLE AS STARTING MATERIAL FOR PRODUCING THE CARBON NANORING, AND METHOD FOR PRODUCING THE COMPOUND - This invention provides: a compound for accurately forming a carbon nanoring that contains a specific number of organic rings and has a definite diameter; a method for producing the compound; a method for efficiently producing a carbon nanoring; and a cycloparaphenylene obtained by the production method. The carbon nanoring of the present invention is a compound obtained by bonding a specific number of organic ring groups. The method for producing a carbon nanoring of the present invention comprises a modification step wherein a halogen atom in a U-shaped compound is modified into a boron compound, and a coupling step wherein the U-shaped compound is subjected to a coupling reaction. The U-shaped compound is a novel compound that has cyclohexane rings, benzene rings, and specific organic ring groups. | 2013-02-14 |
20130041156 | AZAPEPTIDE DERIVATIVES - This invention relates to novel compounds that are azapeptides, and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel azapeptide compounds that are derivatives of the HIV protease inhibitor atazanavir sulfate. This invention also provides pyrogen-free compositions comprising one or more compounds of the invention and a carrier, and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are treated by administering HIV protease inhibitors. The invention also relates to the use of one or more of the disclosed compounds as reagents in analytical studies involving atazanavir. | 2013-02-14 |
20130041157 | THERAPEUTIC AGENT OR PREVENTIVE AGENT FOR URINE COLLECTION DISORDER - A therapeutic agent or prophylactic agent is effective for therapy of urine storage disorders, by which agent improvement of side effects due to an anticholinergic action is attained as well as which agent also has an analgesic effect. The agent includes as an effective ingredient a cyclohexane derivative exemplified by the formula below, a pharmaceutically acceptable salt thereof, or a prodrug thereof. | 2013-02-14 |
20130041158 | THERAPEUTIC AGENT AND PREVENTATIVE AGENT FOR ALZHEIMER'S DISEASE - A therapeutic agent or prophylactic agent for Alzheimer's disease has an effect to inhibit or delay the progress of Alzheimer's disease and exhibits a long-lasting therapeutic effect on Alzheimer's disease even when used for a long period of time. The therapeutic agent or prophylactic agent for Alzheimer's disease includes as an effective ingredient a cyclohexane derivative exemplified by the formula below, or a pharmaceutically acceptable salt thereof or a prodrug thereof. | 2013-02-14 |
20130041159 | PROCESS FOR PURIFYING IONIC LIQUIDS - The present process purifies a salt Cat | 2013-02-14 |
20130041160 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES - The invention relates to a process for the preparation of a compound of formula (I), which process comprises a) reacting a compound of formula (II), wherein X is chloro or bromo, with an organometallic species to (III) reacting the halobenzyne of formula (III) so formed with (IV) wherein R | 2013-02-14 |
20130041161 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES - The invention relates to a process for the preparation of formula (I), which process comprises a) reacting the compound (II), with cyclopentadiene to (III); b) reacting this compound in the presence of an oxidant to the compound of formula (IV); c) hydrogenating this compound in the presence of a metal catalyst and an inert solvent under hydrogen atmosphere to the compound of formula (V); d) reacting this compound in the presence of a Brönsted acid followed by a reducing agent to the compound of formula (VI); e) reacting VI with a compound (VII), in the presence of a base to a compound of formula (VIII); f) converting the compound of formula VIII in the presence of an oxidising agent to the compound of formula (IX); and g) reacting the compound of formula IX in the presence of triphenylphosphane/carbon tetrachloride or triphenylphosphane/bromotrichloromethane to the compound of formula I. | 2013-02-14 |
20130041162 | PRODUCTION OF ATORVASTATIN LOW IN ETHER IMPURITIES - The present invention relates to a method for the production of atorvastatin having decreased levels of impurities of general formulae (3) and (4) by means of a concentrating step. | 2013-02-14 |
20130041163 | PRODUCTION OF ATORVASTATIN LOW IN LACTONE IMPURITIES - The present invention relates to a method for the production of atorvastatin having decreased levels of impurity (3) by means of a pH-controlling step. | 2013-02-14 |
20130041164 | Reduction of Alpha-Tocopherol Quinone - α-tocopherol quinone is chemically reduced by combination with a reducing agent, such as tin (II) ion in the form of stannous chloride (SnCl | 2013-02-14 |
20130041165 | PROCESS FOR PREPARING DIVINYLARENE DIOXIDES - A process for preparing a divinylarene dioxide including reacting (a) at least one divinylarene; (b) at least one oxidant, wherein the at least one oxidant includes a peroxomonosulfate triple salt oxidant, and wherein the at least one oxidant is less than about 2.0 equivalents to C═C; (c) at least one solvent, (d) at least one basic compound, and (e) optionally, at least one catalyst; under conditions to form a divinylarene dioxide product. | 2013-02-14 |
20130041166 | PROCESS FOR THE PREPARATION OF DIENOGEST SUBSTANTIALLY FREE OF IMPURITIES - The present invention provides novel process for preparation and purification of dienogest (I). The present invention provides dienogest (I) substantially free of impurities. | 2013-02-14 |
20130041167 | METHOD OF TREATING TALL OIL PITCH - A method of treating tall oil pitch, which comprises sterol esters of fatty acids. According to the present invention, the esters of sterols and fatty acids are broken down, in which case especially formic acid esters or acetic acid esters of sterols are formed instead. The free fatty acids and sterol esters generated are distilled or separated in another way. Use of the present invention increases the yield of fatty acids and also facilitates the separation of sterols from tall oil pitch. | 2013-02-14 |
20130041168 | EXTRACTION WITH FRACTIONATION OF LIPIDS AND PROTEINS FROM OLEAGINOUS MATERIAL - Systems and methods for extracting lipids of varying polarities from oleaginous material. | 2013-02-14 |
20130041169 | Neutral Bimetallic Transition Metal Phenoxyiminato Catalysts and Related Polymerization Methods - A catalyst composition comprising a neutral bimetallic diphenoxydiiminate complex of group 10 metals or Ni, Pd or Pt is disclosed. The compositions can be used for the preparation of homo- and co-polymers of olefinic monomer compounds. | 2013-02-14 |
20130041170 | ALKYL-SUBSTITUTED ALLYL CARBONYL METAL COMPLEXES AND USE THEREOF FOR PREPARING DIELECTRIC THIN FILMS - Organometallic complexes and use thereof in thin film deposition, such as CVD and ALD are provided herein. The organometallic complexes are (alkyl-substituted η | 2013-02-14 |
20130041171 | MACROMOLECULAR ANTIOXIDANTS BASED ON STERICALLY HINDERED PHENOLS AND PHOSPHITES - A sterically hindered phenol and phosphite based compound represented by the following formula: | 2013-02-14 |
20130041172 | APPARATUS FOR REMOVING CATALYST SURFACE SUBSTANCES - An apparatus for efficiently removing the exuded substance and/or the attached substance on the surface of a catalyst (catalyst surface substance) from the catalyst is provided. The apparatus comprising a main body, the apparatus for removing a catalyst surface substance present on a surface of a catalyst from the catalyst by bringing a gas flow into contact with the catalyst housed in the main body, wherein a gas flow length in a flow direction of the gas flow is 55 mm or more, and an average flow velocity of the gas flow is 80 m/s or more and 500 m/s or less in terms of a linear velocity at 15° C. and 1 atm. | 2013-02-14 |
20130041173 | MODIFIED DIAMOND PARTICLES - Modified diamond particles for use in chromatography with a desired functional group at the diamond surface, formed from reaction of hydroxyl groups at diamond surfaces with a reactive molecule. | 2013-02-14 |
20130041174 | CATALYST FOR ALKYLATION AND PROCESS FOR PRODUCING ALKYLAROMATIC HYDROCARBON COMPOUND USING THE CATALYST - A catalyst for alkylation contains an inorganic structural material having an ion-exchange ability and a metal ion having a valency of 2 or more. The metal ion is supported on the inorganic structural material. The inorganic structural material is preferably a zeolite. The metal ion is preferably a lanthanide metal. The catalyst for alkylation imparts industrially satisfiable activity and selectivity and can be readily separated, collected and recycled. Furthermore, the process for producing an alkylaromatic hydrocarbon compound includes reacting an aromatic hydrocarbon compound and a compound having an unsaturated bond in the presence of the catalyst for alkylation. | 2013-02-14 |
20130041175 | PROCESS FOR OXIDIZING ALKYL AROMATIC COMPOUNDS - A process for oxidizing an alkyl-aromatic compound is described. The process includes contacting the alkyl-aromatic compound, a solvent comprising an ionic liquid, a bromine source, a catalyst, and an oxidizing agent in a first reaction zone to produce a first product comprising a first mother liquor and at least one of an aromatic alcohol, an aromatic aldehyde, an aromatic ketone, and an aromatic carboxylic acid. | 2013-02-14 |
20130041176 | STRUCTURE ASSESSMENT OF HETEROGENEOUS POLYPEPTIDE MIXTURE - Methods of analyzing glatiramer acetate (GA) to assess secondary structure, for example, alpha helical content and/or random coil content thereof are provided as are methods for preparing a composition comprising GA and methods for identifying a copolymer as GA. | 2013-02-14 |
20130041177 | NON-CRYSTALLINE OXIDIZED GLUTATHIONE AND PRODUCTION METHOD THEREFOR - A non-crystalline amorphism of oxidized glutathione is produced by drying a crystal of oxidized glutathione hexahydrate at a temperature of 40 to 90° C. | 2013-02-14 |
20130041178 | METHOD FOR PREPARING OPTICALLY ACTIVE N-METHYLAMINO ACIDS AND OPTICALLY ACTIVE N-METHYLAMINO ACID AMIDES - The present invention relates to a method for preparing optically active N-methylamino acids and/or optically active N-methylamino acid amides by subjecting the cells or treatment products of a microorganism belonging to the | 2013-02-14 |
20130041179 | AMIDE COMPOUND PRODUCTION CATALYST, AND PROCESS FOR PRODUCTION OF AMIDE COMPOUND - The present provides a high-efficiency amide compound production catalyst to be used in producing an amide compound through hydration of a nitrile compound and a production method using it. The amide compound production catalyst is for producing an amide compound through reaction of a nitrile compound and water, and comprises a manganese oxide catalyst containing bismuth and further containing yttrium or vanadium. The method for producing an amide compound comprises reacting a nitrile compound and water in a liquid phase in the presence of the amide compound production catalyst. | 2013-02-14 |
20130041180 | PROCESS FOR PREPARING (R)-2-ACETAMIDO-N-BENZYL-3-METHOXY-PROPIONAMIDE - Processes for preparing and purifying (R)-2-acetamido-N-benzyl-3-methoxy-propionamide of formula-1 and intermediates thereof are provided. | 2013-02-14 |
20130041181 | TITANIUM-SILICALITE MOLECULAR SIEVE, METHOD FOR PREPARING THE SAME AND METHOD FOR PREPARING CYCLOHEXANONE OXIME USING THE MOLECULAR SIEVE - The present invention provides a titanium-silicalite molecular sieve and a method for preparing the same. The method includes the steps of preparing a mixture of a titanium source, a silicon source, a metal source selected from IIA to IVA elements and a template agent; heating the mixture to form a gel mixture; heating the gel mixture in a water bath; and calcining the gel mixture after the gel mixture in the water bath to form the titanium-silicalite molecular sieve. The present invention further provides a method for preparing cyclohexanone oxime by using the titanium-silicalite molecular sieve as the catalyst which results in high conversion rate, high selectivity and high usage efficiency of hydrogen peroxide. | 2013-02-14 |
20130041182 | RECOVERY OF TOLUENE DIAMINE FROM TAR WASTE RESIDUE DISCHARGED FROM SYNTHESIS PROCESS OF TOLUENE DIISOCYANATE - The recovery of toluene diamine from tar waste residues discharged from the synthesis process of toluene diisocyanate comprising steps of: a) grinding the tar waste residues into particles; b) dispersing the particles of tar waste residues into a phase transfer catalyst, alkali and water to obtain a slurry, said phase transfer catalyst being selected from the group consisting of higher alcohols, polyols, polyether compounds and combinations thereof having a boiling point ranging from 120 to 280° C.; c) under the protection of a protective gas, subjecting the slurry to a hydrolysis reaction at a temperature of 120-180° C. under a meter-measured pressure of 0-0.95 MPa to produce toluene diamine; and d) recovering toluene diamine from the hydrolysis reaction solution. The present invention achieves highly efficient recovery of toluene diamine (the recovery rate of TDA is up to 60%) under mild conditions such as 120-180° C. and 0-0.95 MPa (meter-measured pressure), and has a significant economic benefit and friendliness to the environment by recycling the phase transfer catalyst (its recovery rate is up to 99.6%) and water. | 2013-02-14 |
20130041183 | Process for Depolymerizing Polysulfides and the Preparation of Bis-Mercapto-Diethers - The invention related to a process for the preparation of a bismercaptodiether by reacting a polysulfide with a monothiol in the presence of a base and to a process for the depolymerization of a polysulfide by reacting said polysulfide with a monothiol in the presence of a base. These processes enable the preparation of bismercaptodiethers without inorganic salt formation. | 2013-02-14 |
20130041184 | 1,1-BIS[(ETHENYLOXY)METHYL]CYCLOHEXANE AND METHOD OF PRODUCTION OF SAME - A novel compound, 1,1-bis[(ethenyloxy)methyl]cyclohexane having the formula (I) and having a low odor, low volatility and low skin irritability, which is useful as a starting material for a polymerization composition having a low toxicity and excellent curability, adhesiveness and transparency in the ultraviolet light region, and having a special reactivity alone or with another compound, and a method for producing the same: | 2013-02-14 |
20130041185 | FULLERENE DERIVATIVE, METHOD FOR PRODUCING THE SAME, AND ALLERGEN ADSORBENT USING THE SAME - Provided are a novel fullerene derivative which can adsorb quickly and efficiently an allergen which may cause a pollen allergy without releasing the allergen again, does not contain a metal or the like which may cause a harmful effect to a human body, and is easily applicable, impregnable, or chemically bondable onto surface of various materials; and a process for producing the same. The fullerene derivative is characterized in that a halogen group and many hydroxyl groups are bonded directly to a fullerene nucleus. In the case that the halogen group is chlorine, the fullerene derivative can be synthesized by a partial hydroxylation of a chlorinated fullerene or a partial chlorination of a hydroxylated fullerene. | 2013-02-14 |
20130041186 | Olefin Hydration Process with an Integrated Membrane Reactor - An olefin hydration process and reactor are provided, wherein an integrated membrane selectively removes alcohol product from the reactor, thereby allowing for increased yields. | 2013-02-14 |
20130041187 | BUTANOL MANUFACTURING METHOD - Highly pure butanol can be produced by a method for producing butanol, the method comprising: Step A, wherein a butanol-containing solution is filtered through a nanofiltration membrane and a butanol-containing solution is recovered from the permeate side; Step B, wherein the butanol-containing solution obtained in Step A is passed through a reverse osmosis membrane and thereby concentrated to cause two-phase separation into a butanol phase and an aqueous phase; and Step C, wherein butanol is recovered from the butanol phase obtained in Step B. | 2013-02-14 |
20130041188 | PROCESS FOR PURIFYING WASTEWATERS FROM THE WORKUP OF CRUDE AROMATIC NITRO COMPOUNDS - The invention relates to a process for purifying crude aromatic nitro compounds which originate from the nitration of aromatic compounds, comprising the following wash stages (a1) and (a2), where each of stages (a1) and (a2) may be performed once or more than once in succession:
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20130041189 | PROCESS FOR PURIFYING WASTEWATERS FROM THE WORKUP OF CRUDE AROMATIC NITRO COMPOUNDS - The invention relates to a process for purifying crude aromatic nitro compounds which originate from the nitration of aromatic compounds, comprising the single or multiple performance of the following wash stage (a): | 2013-02-14 |
20130041190 | PROCESS FOR THE MANUFACTURE OF 2-CHLORO-3,3,3-TRIFLUOROPROPENE (HFCO 1233xf) BY LIQUID PHASE FLUORINATION OF PENTACHLOROPROPANE - Process of catalytic fluorination in liquid phase of product 1,1,1,2,3-pentachloropropane or/and 1,1,2,2,3-pentachloropropane into product 2-chloro-3,3,3-trifluoropropene in presence of a catalyst. | 2013-02-14 |
20130041191 | PROCESS OF FLUORINATION IN LIQUID PHASE - The present invention provides a process of fluorination in liquid phase in a solvent medium of a compound of formula (II) CX | 2013-02-14 |
20130041192 | METHOD OF UTILIZING TALL OIL PITCH - A method of treating tall oil pitch. In the present method, part of the fatty acids and the resin acids are released from their sterol esters and wood alcohol esters and converted into methanol esters or ethanol esters. The transesterified products are removed from the pitch by evaporation and then condensed, and by hydrogenating the generated condensate the acids are decarboxylated and the double bonds are satisfied. It is possible to use the present method to produce automotive fuel from tall oil pitch. | 2013-02-14 |
20130041193 | METHOD FOR PRODUCING A COMPOSITE MATERIAL - A method for producing a composite material which contains a support material and an ionic liquid, as well as a composite material and its use as synthetic catalyst. | 2013-02-14 |
20130041194 | CATALYST AND ISOMERISATION PROCESS - An alkylaromatics isomerisation catalyst, which catalyst comprises at least 50 wt % of an inorganic binder; at least 0.01 wt % of a Group VIII metal and 1-9 wt % ZSM-12 zeolite wherein the silica to alumina molar ratio (SAR) of the ZSM-12 zeolite is in the range of from 60 to 200, and a process for the isomerisation of alkylaromatics to provide a reaction mixture, said process comprising contacting a hydrocarbon stream comprising alkylaromatics with such catalyst. | 2013-02-14 |
20130041195 | Systems And Methods For Controlling Transport Reactors - Systems and methods for operating transport reactors are provided. The method can include fluidizing one or more particulates within a transport reactor. The one or more particulates can include one or more carbonaceous materials. The method can also include maintaining one or more pressure differentials between two or more points within the transport reactor using at least one integrally geared compression system. The at least one integrally geared compression system can include a bull gear, at least one pinion, and two or more compressors. | 2013-02-14 |
20130041196 | DEHYDRATION OF ALCOHOLS ON A CRYSTALLINE SILICATE OF LOW Si/Al RATIO - The present invention (in a first embodiment) relates to a process for the dehydration of an alcohol having at least 2 carbon atoms to make the corresponding olefin, comprising:
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20130041197 | METHOD OF PREPARING ALKENE COMPOUND - Disclosed is a method of preparing an alkene compound including introducing an acidic catalyst and a solvent into a reactor, increasing a temperature the reactor, and continuously removing water from the reactor while continuously supplying an alcohol into the reactor and continuously collecting an alkene compound. | 2013-02-14 |
20130041198 | Highly Active Decomposition Catalyst for Low Carbon Hydrocarbon Production from Sulfur Containing Fuel - Methods for deriving a low-C hydrocarbon fuel from a high-C hydrocarbon fuel are generally provided. A catalytic material (e.g., an aluminosilicate and/or a zeolite) can be introduced to the high-C hydrocarbon fuel to produce a product stream comprising a low-C hydrocarbon fuel, and the low-C hydrocarbon fuel can be separated in the product stream from any remaining high-C hydrocarbon fuel. | 2013-02-14 |
20130041199 | METHOD FOR THE SUBLIMATION OR PYROLYSIS OF HYDROCARBONS USING RF ENERGY TO BREAK COVALENT BONDS - High power RF energy supplied to a reaction chamber at a resonant frequency is used to break the covalent bonds of a hydrocarbon material without heat. An RF signal generator may be used to supply RF energy to a resonant ring through a four port coupler. The phase of the RF energy passing through the resonant ring may be adjusted to achieve an integral multiple of a resonant wavelength. Wavelength and intensity may be adjusted to sublimate or pyrolyze the hydrocarbon material to yield a useful gaseous product. | 2013-02-14 |
20130041200 | METHOD OF TREATING EFFLUENTS CONTAINING HALOGENATED COMPOUNDS - The present invention relates to the use of catalysts of general formula (I): | 2013-02-14 |
20130041201 | System and Method for Collecting, Storing, Processing, Transmitting and Presenting Very Low Amplitude Signals - A method and apparatus for producing an effect of a chemical or biochemical agent on a system responsive to such agent, are disclosed. In practicing the method, a plurality of low-frequency time-domain signals of the agent are generated, each at a different at a different noise level within a selected noise level range. The signals are analyzed by producing spectral plots of the time-domain signals, and identifying an optimized agent-specific time-domain signal based on information in the spectral plots. A chemical or biological system responsive to the agent is exposed to the optimized time-domain signal by placing the system within the magnetic field of an electromagnetic transducer, and applying the signal to the transducer at a signal amplitude and for a period sufficient to produce in the system an agent-specific effect on the system. | 2013-02-14 |
20130041202 | FLUID PUMP HAVING A RADIALLY COMPRESSIBLE ROTOR - To design the rotor ( | 2013-02-14 |
20130041203 | BLOOD FLOW ASSIST DEVICES, SYSTEMS AND METHODS - An implantable pump system for assisting blood flow includes a flexible conduit, at least one movable valve in fluid connection with the flexible conduit, a drive system comprising a rotary motor and a speed reducer operatively connected to the rotary motor; and a converter operatively connected to the drive system and operatively connected to the valve to drive the valve in a reciprocating linear manner. In a number of embodiments, the speed reducer includes a spur gear driving a ring gear, wherein the converter is operatively connected to the speed reducer. | 2013-02-14 |
20130041204 | CONTROL OF BLOOD FLOW ASSIST SYSTEMS - In one aspect, an implantable pump system for assisting blood flow in a patient includes a blood flow path comprising a flexible conduit, at least one valve in fluid connection with the flexible conduit, a drive system in operative connection with the valve to move the valve in a reciprocating manner, an implantable control system and at least one sensor in communicative connection with the control system. The sensor is adapted to measure at least one property of blood. The control system is adapted to control movement of the valve on the basis of data regarding position of the valve with respect to time or a derivative thereof (that is, position, velocity, acceleration or a derivative thereof) in combination with data of the measured at least one property of blood from the sensor. | 2013-02-14 |
20130041205 | METHOD AND APPARATUS FOR PUMPING BLOOD - A pump system is disclosed for pumping blood from a patient's right atrium or right ventricle to a patient's pulmonary artery, the pump system including a distal section having at least one outlet; a pumping section in fluid communication with the distal section to provide blood to the outlet of the distal section, the pumping section having at least one inlet valve to receive blood; and a pump constructed and arranged to be positioned within the pumping section to draw blood into the pumping section in a first phase of operation and to pump blood out of the outlet of the distal section in a second phase of operation. | 2013-02-14 |
20130041206 | EPIDERMAL DOWN-GROWTH BARRIER - A percutaneous implant for reducing the risk of post-implant infection by reducing the likelihood of epidermal down-growth between the dermis of the skin and the implant. In one example, the implant comprises a barrier member between the epidermis and the dermis about the implant. In another example, a barrier is provided by removing a portion of the epidermis from the dermis about the implant. | 2013-02-14 |
20130041207 | SHAPE MEMORY CONTROLLER - An apparatus for selectively opening and closing a body lumen within a patient's body is provided. The apparatus includes an elongate member and a shape memory element. The elongate member is configured to at least partially surround the body lumen and defines a lumen. The shape memory element is disposed of adjacent to the lumen defined by the elongate member. Further, the shape memory element is adapted to change its configuration based on a change in temperature. These changes in the configuration of the shape memory element causes selective the apparatus to move between a first configuration and a second configuration. | 2013-02-14 |
20130041208 | SURGICAL ARTICLES FOR PLACING AN IMPLANT ABOUT A TUBULAR TISSUE STRUCTURE AND METHODS - A minimally invasive surgical instrument for placing an implantable article about a tubular tissue structure is disclosed. The surgical instrument is particularly useful for treating urological disorders such as incontinence. Surgical methods using the novel instrument are also described. | 2013-02-14 |
20130041209 | METHODS AND COMPOSITIONS FOR IMPROVED FERTILIZATION AND EMBRYONIC SURVIVAL - Single nucleotide polymorphic sites of the bovine HSP genes are associated with improved fertilization rate and/or improved embryo survival rate in cattle. Nucleic acid molecules, kits, methods of genotyping and marker assisted bovine breeding methods based on these SNPs are disclosed. | 2013-02-14 |
20130041210 | Process for the Synchronization of Ovulation for Timed Breeding Without Heat Detection - A method for synchronizing ovulation in sows and gilts by a single injection of hormones is disclosed. A hormone, gonadotropin releasing hormone (GnRH), luteinizing hormone (LH), follicle stimulating hormone (FSH), human chorionic gonadotropin (hCG), analogues, derivatives, agonists or combinations thereof is administered to an open sow post weaning at a specific time to stimulate ovulation of mature responsive follicles. The sow is then bred, without heat detection, at a specific subsequent timed interval after injection with hormone, with one or two artificial or natural breedings. In gilts, the hormone is injected at a timed interval from onset of estrus or at a specific timed interval following Prostaglandin F2a for those gilts which have been held in a state of pseudopregnancy. | 2013-02-14 |
20130041214 | METHODS AND APPARATUS FOR OFF-AXIS VISUALIZATION - Methods and apparatus for off-axis visualization are described herein. An endoluminal tissue manipulation assembly is disclosed which provides for a stable endoluminal platform and which also provides for effective triangulation of tools. Such an apparatus may comprise an optionally shape-lockable elongate body defining a longitudinal axis and adapted for endoluminal advancement in a patient body, at least one articulatable visualization lumen disposed near or at a distal region of the elongate body, the at least one articulating visualization lumen being adapted to articulate off-axis relative to a longitudinal axis of the elongate body, and at least one articulatable tool arm member disposed near or at the distal region of the elongate body, the at least one articulatable tool arm member being adapted to articulate off-axis and manipulate a tissue region of interest. | 2013-02-14 |
20130041215 | FEATURE DIFFERENTIATION IMAGE CAPTURE UNIT AND METHOD IN A SURGICAL INSTRUMENT - In a minimally invasive surgical system, an image capture unit includes a prism assembly and sensor assembly. The prism assembly includes a beam splitter, while the sensor assembly includes coplanar image capture sensors. Each of the coplanar image capture sensors has a common front end optical structure, e.g., the optical structure distal to the image capture unit is the same for each of the sensors. A controller enhances images acquired by the coplanar image capture sensors. The enhanced images may include (a) visible images with enhanced feature definition, in which a particular feature in the scene is emphasized to the operator of minimally invasive surgical system; (b) images having increased image apparent resolution; (c) images having increased dynamic range; (d) images displayed in a way based on a pixel color component vector having three or more color components; and (e) images having extended depth of field. | 2013-02-14 |
20130041216 | INCREASED RESOLUTION AND DYNAMIC RANGE IMAGE CAPTURE UNIT IN A SURGICAL INSTRUMENT AND METHOD - In a minimally invasive surgical system, an image capture unit includes a prism assembly and sensor assembly. The prism assembly includes a beam splitter, while the sensor assembly includes coplanar image capture sensors. Each of the coplanar image capture sensors has a common front end optical structure, e.g., the optical structure distal to the image capture unit is the same for each of the sensors. A controller enhances images acquired by the coplanar image capture sensors. The enhanced images may include (a) visible images with enhanced feature definition, in which a particular feature in the scene is emphasized to the operator of minimally invasive surgical system; (b) images having increased image apparent resolution; (c) images having increased dynamic range; (d) images displayed in a way based on a pixel color component vector having three or more color components; and (e) images having extended depth of field. | 2013-02-14 |
20130041217 | CAPSULE MEDICAL DEVICE GUIDING SYSTEM AND MAGNETIC FIELD GENERATING DEVICE - A guiding system includes a capsule medical device including a permanent magnet; a magnetic field generating unit to generate a magnetic field to the magnet to guide the capsule, and change a direction of the magnetic field in a three-dimensional space; and a control unit to control the magnetic field generated by the generating unit. Where the capsule is located on a liquid surface, the control unit generates a first magnetic field such that a plane, which is parallel to a vertical axis and in which a magnetic field including a rotating magnetic field where a magnetic field is rotated on the plane is generated, pivots about the vertical axis at a predetermined period and a second magnetic field for generating a magnetic attracting force for moving the magnet vertically downward to submerge the capsule in the liquid, the first and second magnetic fields being applied at a same time. | 2013-02-14 |
20130041218 | ENDOSCOPIC DEVICE - An endoscopic device that irradiates a plurality of illuminating light having different spectrums from each other onto a subject at a front edge of an endoscope inserting module and captures the subject to obtain an observation image The endoscopic device includes an illuminating module, an imaging module, a light intensity ratio control module, and a color tone correcting module. The illuminating module generates the plurality of illuminating light. The imaging module captures the subject and output an image signal of the observation image. The light intensity ratio control module controls the illuminating module to irradiate the plurality of illuminating light onto the subject with a set light intensity ratio by setting the light intensity ratio of the plurality of illuminating light. The color tone correcting module corrects the color tone to obtain the observation image with substantially the same color tone even though the light intensity ratio is changed. | 2013-02-14 |
20130041219 | MEDICAL MANIPULATOR AND SURGICAL SUPPORT APPARATUS - A medical manipulator includes: a holding portion whose proximal end portion is fixed to a base; a positioning portion that has a fixing portion that is fixed to a distal end portion of the holding portion, and that is formed such that a treatment portion of a surgical instrument is able to move relative to the fixing portion; a reference orientation detecting portion that detects an orientation of a reference position on the positioning portion; a drive section that is used to move the treatment portion relative to the fixing portion; and a displacement detecting section that detects an amount of movement, including angular displacement, of the treatment portion relative to the reference position, and that calculates as the orientation on the treatment portion an orientation that is different by an amount of angular displacement that it has itself detected from the orientation on the reference position detected by the reference orientation detecting portion. | 2013-02-14 |
20130041220 | ENDOSCOPE SYSTEM - An endoscope system is an endoscope system including a first endoscope and a second endoscope, the first endoscope including a first frequency correction section, and the second endoscope not including the first frequency correction section, and a video processor, wherein the video processor includes a frequency correction information storage section which stores third frequency correction information based on the endoscope information of the second endoscope, a correction amount acquiring section which acquires second frequency correction information for performing frequency correction in concert with frequency correction processing by the first frequency correction section when the first endoscope is connected and acquires the third frequency correction information from the frequency correction information storage section when the second endoscope is connected, and a second frequency correction section which performs frequency correction on the video signal from the endoscopes on the basis of the correction information acquired by the correction amount acquiring section. | 2013-02-14 |
20130041221 | IMAGE CAPTURE UNIT AND AN IMAGING PIPELINE WITH ENHANCED COLOR PERFORMANCE IN A SURGICAL INSTRUMENT AND METHOD - In a minimally invasive surgical system, an image capture unit includes a prism assembly and sensor assembly. The prism assembly includes a beam splitter, while the sensor assembly includes coplanar image capture sensors. Each of the coplanar image capture sensors has a common front end optical structure, e.g., the optical structure distal to the image capture unit is the same for each of the sensors. A controller enhances images acquired by the coplanar image capture sensors. The enhanced images may include (a) visible images with enhanced feature definition, in which a particular feature in the scene is emphasized to the operator of minimally invasive surgical system; (b) images having increased image apparent resolution; (c) images having increased dynamic range; (d) images displayed in a way based on a pixel color component vector having three or more color components; and (e) images having extended depth of field. | 2013-02-14 |
20130041222 | ENDOSCOPE - An endoscope includes a drive force transmitting section attached to an insertion main body, and configured to transmit rotational drive force that rotates an attachment unit to the attachment unit, and a member inserting portion provided to a proximal direction side of an insertion section. The endoscope includes a first linear member insertable into the insertion section from the member inserting portion and removable from the insertion section through the member inserting portion, and has a distal end connectable to the drive force transmitting section while being inserted into the insertion section. The first linear member is configured to transmit the rotational drive force to the drive force transmitting section when rotated while being connected to the drive force transmitting section. | 2013-02-14 |
20130041223 | ENDOSCOPE - An endoscope of the present invention includes a cover member, a groove formed on an outer circumferential face of the cover member, holes which are located at least two places in a circumferential direction of the groove and communicate with the interior of the cover member, a bending portion and a loop-shaped puller wire wound around the groove so as to enter the groove from within the cover member through the hole at one end in the cover member and enter the cover member from the groove through the hole at the other end. | 2013-02-14 |
20130041224 | ENDOSCOPE - An endoscope includes an active bending portion provided in an insertion portion and bendable according to a bending operation, the active bending portion including bending pieces adjacent to each other and pivotably connected together via a plurality of rotation shafts, the rotation shafts being located at positions differing by 90° in a circumferential direction J of the bending pieces, and a passive bending portion provided closer to the proximal end side than the active bending portion and passively bendable when an external force is applied thereto, the passive bending portion including bending pieces adjacent to each other and pivotably connected together via a plurality of rotation shafts, the rotation shafts being located at positions differing by 60° in the circumferential direction J. | 2013-02-14 |
20130041225 | ENDOSCOPY SYSTEM AND A PRESSURE TRANSMITTING CONNECTOR FOR SAID SYSTEM - The inventive endoscopy system includes a cannula for arranging an endoscope and forming, between said cannula and endoscope, an irrigation or aspiration channel for transporting an irrigation or aspiration fluid, respectively, a connection ring mounted around the cannula and provided with a connection channel connectable to the irrigation or aspiration channel, respectively and a connector which is mounted on the connection ring and includes a transport channel with the connection channel and a first pressure sensor for detecting pressure in the transport channel. The connection ring is provided with a bypass circuit connectable to the irrigation or aspiration channel, respectively and the connector including a dead channel connectable to the bypass circuit and a second pressure sensor for detecting pressure in the dead channel. | 2013-02-14 |
20130041226 | IMAGE CAPTURE UNIT IN A SURGICAL INSTRUMENT - In a minimally invasive surgical system, an image capture unit includes a prism assembly and sensor assembly. The prism assembly includes a beam splitter, while the sensor assembly includes coplanar image capture sensors. Each of the coplanar image capture sensors has a common front end optical structure, e.g., the optical structure distal to the image capture unit is the same for each of the sensors. A controller enhances images acquired by the coplanar image capture sensors. The enhanced images may include (a) visible images with enhanced feature definition, in which a particular feature in the scene is emphasized to the operator of minimally invasive surgical system; (b) images having increased image apparent resolution; (c) images having increased dynamic range; (d) images displayed in a way based on a pixel color component vector having three or more color components; and (e) images having extended depth of field. | 2013-02-14 |
20130041227 | LIGHTWAND FOR ORAL/NASAL INTUBATION - According to some embodiments, a light wand is described that can be used for fast, easy and non-traumatic oral and nasal tracheal intubation. A flexible light wand assembly includes an adapter plate that is compatible with existing standard laryngoscope handles. | 2013-02-14 |
20130041228 | MINIMALLY INVASIVE RETRACTOR AND METHODS OF USE - A device, system and method for orthopedic spine surgery using a novel screw-based retractor, disclosed herein, that allows for access to the spine through a minimally or less invasive approach. The retractor device is designed to be coupled to a pedicle screw and then to have opposed arms of the retractor spread apart to open the wound proximally. The retractor is removed by pulling it out of the wound whereby the retractor is deformed to pass over the pedicle screw head. The retractor is intended to be made of a stiff plastic material, sterile packaged and disposable after one use. A system and method for using the retractor and performing a minimally invasive spine surgical procedure are also disclosed. | 2013-02-14 |
20130041229 | MINIMALLY OBSTRUCTIVE RETRACTOR - This application presents minimally-obstructive and structurally-adjustable retractors which afford an open work area of desirable size and enhanced visualization for a surgeon about the perineum and the posterior vaginal wall of the patient. The retractors may be lightweight and compact, and also configured and dimensioned to minimize slippage during use. The retractors may retract the engorged labia of the postpartum patient as well as the vaginal walls. The device may also be used as a speculum. | 2013-02-14 |
20130041230 | SURGICAL INSTRUMENT CLEANING ARRANGEMENT - An instrument cleaning apparatus facilitates the cleaning of a scope utilized during a surgical procedure. The instrument cleaning apparatus includes a base portion and a fluid retention portion. The base portion includes a substantially tubular wall having a proximal end and a distal end and a longitudinal passageway extending therethrough. The fluid retention portion is in mechanical cooperation with the base portion and is adapted to retain a cleaning fluid therein. The fluid retention portion may be contacted by the scope. | 2013-02-14 |
20130041231 | Instrument Access Device - An instrument access device | 2013-02-14 |
20130041232 | DEVICES AND METHODS FOR CONTROLLING DEPTH OF INSERTION - A medical device and a method for preparing a patient's body to receive a bodily implant are disclosed. The medical device includes a needle member configured to be inserted into a tissue layer. The needle member has a proximal end portion and a distal end portion. An adjustment member is coupled to the proximal end portion of the needle member. The adjustment member includes an adjustment screw and a nut for setting a predetermined depth of insertion of the needle member within the tissue layer. The adjustment member further includes an adjustment member support configured to provide a support to the adjustment screw and the nut. The adjustment member is configured to move between a first position and a second position with respect to the adjustment member support to limit insertion of the needle member within the tissue layer to the predetermined depth. | 2013-02-14 |