07th week of 2009 patent applcation highlights part 43 |
Patent application number | Title | Published |
20090042252 | INTERFERON-ALPHA POLYPEPTIDES AND CONJUGATES - The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids. | 2009-02-12 |
20090042253 | USE OF PERFUSION TO ENHANCE PRODUCTION OF FED-BATCH CELL CULTURE IN BIOREACTORS - The invention relates to methods of improving protein production, e.g., large-scale commercial protein production, e.g., antibody production, utilizing a modified fed-batch cell culture method comprising a cell growth phase and a polypeptide production phase. The modified fed-batch cell culture method combines both cell culture perfusion and fed-batch methods to achieve higher titers of polypeptide products. Because the modified fed-batch cell culture method of the invention produces higher polypeptide product titers than fed-batch culture alone, it will substantially improve commercial-scale protein production. The invention also relates to a perfusion bioreactor apparatus comprising a fresh medium reservoir connected to a bioreactor by a feed pump, a recirculation loop connected to the bioreactor, wherein the recirculation loop comprises a filtration device, e.g., ultrafiltration or microfiltration, and a permeate pump connecting the filtration device to a permeate collection container. | 2009-02-12 |
20090042254 | EXPRESSION OF SOLUBLE ANTIBODY FRAGMENT BY TRUNCATION OF CH1 DOMAIN - Improved expression of active antibody fragments (Fabs) is achieved by truncating a heavy chain constant region. Truncation of the C | 2009-02-12 |
20090042256 | REACTOR PLATE AND REACTION PROCESSING METHOD - Disclosed herein is a reactor plate including a sealed reaction well, a reaction well channel connected to the reaction well, and a reaction well air vent channel connected to the reaction well. The reaction well contains a reagent contained in the bottom thereof and a thermally fusible material which is solid at room temperature and is contained in the bottom thereof to encapsulate the reagent. When the reaction well is heated, the thermally fusible material is melted, and as a result, a sample liquid introduced into the reaction well through the reaction well channel reacts with the reagent in the reaction well. | 2009-02-12 |
20090042257 | Adenoviral fiber exchange shuttle system - The instant invention provides methods and compositions for generating recombinant adenoviral vectors. The invention also provides kits comprising for the generation of recombinant adenoviral vectors. | 2009-02-12 |
20090042258 | Methods and Compositions for DNA Manipulation - Methods and compositions are provided for generating a single-stranded extension on a polynucleotide molecule, the single-stranded extension having a desired length and sequence composition. Methods for forming single-stranded extensions include: the use of a cassette containing at least one nicking site and at least one restriction site at a predetermined distance from each other and in a predetermined orientation; or primer-dependent amplification which introduces into a polynucleotide molecule, a modified nucleotide which is excised to create a nick using a nicking agent. The methods and compositions provided can be used to manipulate a DNA sequence including introducing site specific mutations into a polynucleotide molecule and for cloning any polynucleotide molecule or set of joined polynucleotide molecules in a recipient molecule such as a vector of choice. | 2009-02-12 |
20090042259 | Process for enzymatically converting a plant biomass - The present invention describes a process for at least a 90% conversion of a plant biomass preferably by a reduction of the units of cellulase needed and by using a xylanase which acts synergistically with the cellulase to improve the yield of xylose and glucose as sugars. The process enables greater conversion of a lignocellulosic plant biomass to glucose and xylose for use as animal feeds and as fermentation as medium for producing ethanol. | 2009-02-12 |
20090042260 | PROCESS FOR PREPARING OPTICALLY ACTIVE (S OR R)-ALPHA-AMINO ACID AND OPTICALLY ACTIVE (R OR S)-ALPHA-AMINO ACID ESTER - The present invention discloses a process for preparing an optically active (S or R)-α-amino acid represented by the formula (II): | 2009-02-12 |
20090042261 | PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE 5-SUBSTITUTED 2-OXAZOLIDINONES FROM RACEMIC EPOXIDES AND CYANATE EMPLOYING A HALOHYDRIN DEHALOGENASE - A process for the production of an optically enriched oxazolidinone of the formula (2a) or (2b), by reacting an epoxide of the formula (1) with cyanate in the presence of halo-hydrin dehalogenase. | 2009-02-12 |
20090042262 | Preparation of Pregabalin and Related Compounds - Materials and Methods for preparing (S)-(+)-3-aminomethyl-5-methyl-hexanoic acid and structurally related compounds via enzymatic kinetic resolution are disclosed. | 2009-02-12 |
20090042263 | Immobilized Enzymes and Methods of Using Thereof - The disclosed matter relates to immobilized enzymes and methods of use thereof. | 2009-02-12 |
20090042264 | COMPOSITIONS AND METHODS FOR MANIPULATING CARBON FLUX IN CELLS - Nucleotide sequences and genetic constructs that can be used to regulate genes encoding enzymes that change carbon flux through metabolic pathways that lead to lactic acid or fumarate production in a host cell, such as a | 2009-02-12 |
20090042265 | Thermophilic Microorganisms with Inactivated Lactate Dehydrogenase Gene (LDH) for Ethanol Production - A mutated thermophilic microorganism is prepared, with a modification to inactivate the lactate dehydrogenase gene of a wild-type microorganism. The mutated microorganism is used in the production of ethanol, utilising C | 2009-02-12 |
20090042266 | TREATMENT OF CELLULOSIC MATERIAL AND ENZYMES USEFUL THERERIN - The present invention relates to the production of sugar hydrolysates from cellulosic material. The method may be used e.g. for producing fermentable sugars for the production of bioethanol from lignocellulosic material. Cellulolytic enzymes and their production by recombinant technology is described, as well as uses of the enzymes and enzyme preparations. | 2009-02-12 |
20090042267 | Food waste treatment device using microorganisms - The present invention is directed to a composition for decomposing a majority of food waste into water and carbon dioxide comprising an effective combination of at least two species of microorganisms chosen from | 2009-02-12 |
20090042268 | IMINOSUGAR COMPOUNDS WITH ANTIFLAVIRUS ACTIVITY - An anti-viral compounds effective against viruses belonging to the Flaviviridae family, wherein the anti-viral compounds are 1,5-dideoxy-1,5-imino-D-glucitol derivative compounds having the general formula (I) | 2009-02-12 |
20090042269 | Isolation of quiescin-sulfhydryl oxidase from milk - Methods for isolating a highly purified QSOX enzyme from milk or whey are described. The enzyme may be used to generate intermolecular and intramolecular disulfide bridges and to facilitate oxidative protein folding. | 2009-02-12 |
20090042270 | ACTIVATABLE RECOMBINANT NEUROTOXINS - Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids. | 2009-02-12 |
20090042271 | Esters of long-chain alcohols and preparation thereof - Disclosed are esters and a process for the preparation of the esters represented by formula 1: | 2009-02-12 |
20090042272 | Processing of Peptides and Proteins - The invention provides novel methionine aminopeptidase enzymes and their use. | 2009-02-12 |
20090042273 | RECOVERY OF VIRUS FROM CELL CULTURE USING HYPERTONIC SALT SOLUTION - A process of harvesting a herpesvirus from a cell culture infected therewith comprises treating said culture with a hypertonic aqueous salt solution to yield a virus suspension, e.g. to give improved yield of virus for live virus vaccine where otherwise cell-disruption might be used to harvest the virus by disrupting virus-infected cells. The harvesting step can be followed e.g. by nuclease treatment, diafiltration and lyophilisation. | 2009-02-12 |
20090042274 | Method of Purifying Virus Envelope - An industrial purification method of a virus (e.g., Hemagglutinating Virus of Japan, HVJ) envelope is provided. To be specific, a method of purifying an inactivated virus envelope at a high recovery rate by ion exchange chromatography and hydrophobic chromatography, while maintaining the cell fusion activity of the virus, is provided. The purified virus envelope can be used as a vector for introducing a biopolymer such as gene and the like into a cell or a living organism. In addition, this method can be used for purification of an attenuated envelope virus. | 2009-02-12 |
20090042275 | NOVEL PLASMIDS AND UTILIZATION THEREOF - A shuttle vector is constructed by preparing a DNA region replicable in bacteria belonging to the genus | 2009-02-12 |
20090042276 | USE OF HOP ACIDS IN FUEL ETHANOL PRODUCTION - Six hop acids are common to hops and beer: alpha acid, beta acids, isoalpha acids, rho-isoalpha acids, tetrahydro-isoalpha acids, and hexahydro-isoalpha acids. The six hop acids were tested to determine which were the most effective in inhibiting the growth of bacteria common to fuel ethanol production. The bacteria used in the tests were | 2009-02-12 |
20090042277 | NUCLEIC ACIDS ENCODING RECOMBINANT SOLUBLE ENDOPROTEASES - The present invention relates to the expression and secretion in | 2009-02-12 |
20090042278 | Method of protein production in yeast - Vectors, host cells, and methods are provided for the production of proteins in yeast. The vectors generally contain a selection gene, a yeast 2 micron sequence, and a polynucleotide encoding a polypeptide, where the polynucleotide is operably linked to promoter, and where the polynucleotide contains one or more yeast-preferred codons. Host cells are cultured under conditions where, after an initial batch phase, oxygen concentration is kept high and glucose feed is regulated so that the yeast cells stay in respiratory metabolism. | 2009-02-12 |
20090042279 | METHOD OF DETECTING MILD IMPAIRED GLUCOSE TOLERANCE OR INSULIN SECRETORY DEFECT - It is intended to provide a noninvasive method of conveniently detecting mild impaired glucose tolerance and/or insulin hyposecretion at the early stage with the use of an enzyme. Namely, mild impaired glucose tolerance and/or insulin hyposecretion at the early stage are detected by quantifying myoinositol secreted into the urine before loading glucose and after loading glucose for a definite period of time with the use of a reagent and comparing the increase (or the increase ratio) in the myoinositol content thus measured with a characteristic level which has been preliminarily determined in normal subjects. | 2009-02-12 |
20090042280 | FLUIDIC CARTRIDGES FOR ELECTROCHEMICAL DETECTION OF DNA - A flow cell cartridge for the detection of differences in nucleic acid sequences is disclosed. The flow cell cartridge has an electrode array and two openings, in which one opening is for the entry and exit of sample, and the other opening is for the control of the entry and exit of sample through the exertion of negative and positive pressure. The entire flow cell cartridge can be moved from sample to sample to allow different samples to be drawn into the cartridge into contact with an electrochemical electrode array, thus allowing reactions to occur in the chamber itself. | 2009-02-12 |
20090042281 | COMPOUND PROFILING DEVICES, SYSTEMS, AND RELATED METHODS - High throughput compound profiling systems, and related devices and sub-systems that can be used to perform various compound profiling processes are provided. These systems typically include work perimeters that are organized for optimum efficiency and processing accuracy. Further, these systems are readily adaptable for performing a wide array of assays, as many different system components are easily incorporated or interchangeable in a particular system. System components that are provided by the invention include cell culture dissociators, which can be used, e.g., to effect cell wetting, dissociation, and/or agitation applications. In some embodiments, these cell culture dissociators are included as components of automated cell culture passaging stations. Dispensing devices that permit on-the-fly fluid temperature regulation are also provided. In addition, various compound profiling methods, cell dissociation methods, uniform cell concentration dispensing methods, among other processes, are also provided. | 2009-02-12 |
20090042282 | PREPARATION OF PROTECTIVE ANTIGEN - A polynucleotide sequence is provided comprising a nucleic acid sequence encoding recombinant Protective Antigen (rPA). | 2009-02-12 |
20090042283 | OPTIMIZED MESSENGER RNA - The present invention is directed to a synthetic nucleic acid sequence which encodes a protein wherein at least one non-common codon or less-common codon is replaced by a common codon. The synthetic nucleic acid sequence can include a continuous stretch of at least 90 codons all of which are common codons. | 2009-02-12 |
20090042284 | Method for labeling/separation of cells and agent for labeling/separation of cells - Disclosed are a cell labeling/separation method and a cell labeling/separation agent capable of identifying a target cell in a simplified manner while achieving a significantly high degree of accuracy in cell separation. The method comprises adding a micro- or nano-capsule | 2009-02-12 |
20090042285 | Antibodies at T cell receptor mimics, methods of production and uses thereof - The present invention relates to a methodology of producing antibodies that recognize peptides associated with a tumorigenic or disease state, wherein the peptides are displayed in the context of HLA molecules. These antibodies will mimic the specificity of a T cell receptor (TCR) but will have higher binding affinity such that the molecules may be used as therapeutic, diagnostic and research reagents. The method of producing a T-cell receptor mimic of the present invention includes identifying a peptide of interest, wherein the peptide of interest is capable of being presented by an MHC molecule. Then, an immunogen comprising at least one peptide/MHC complex is formed, wherein the peptide of the peptide/MHC complex is the peptide of interest. An effective amount of the immunogen is then administered to a host for eliciting an immune response, and serum collected from the host is assayed to determine if desired antibodies that recognize a three-dimensional presentation of the peptide in the binding groove of the MHC molecule are being produced. The desired antibodies can differentiate the peptide/MHC complex from the MHC molecule alone, the peptide alone, and a complex of MHC and irrelevant peptide. Finally, the desired antibodies are isolated. | 2009-02-12 |
20090042286 | USE OF THE ACA GLYCOPROTEIN FOR OBTAINING/MAINTAINING PLURIPOTENT NON-EMBRYONIC STEM CELLS - Described is the use of a glycosylphosphatidylinositol (GPI)-anchored glycoprotein ACA or activator of ACA for obtaining pluripotent non-embryonic stem cells or for maintaining the pluripotenial phenotype of non-embryonic stem cells. | 2009-02-12 |
20090042287 | PDX1 EXPRESSING ENDODERM - Disclosed herein are cell cultures comprising PDX1-positive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified PDX1-positive endoderm cells as well as methods for enriching, isolating and purifying PDX1-positive endoderm cells from other cell types. Methods of identifying differentiation factors capable of promoting the differentiation of endoderm cells, such as PDX1-positive foregut endoderm cells and PDX1-negative definitive endoderm cells, are also disclosed. | 2009-02-12 |
20090042288 | Method of Producing Organotypic Cell Cultures - The present invention relates to cell and tissue culture. In particular, the present invention provides a method for preparing an organotypic culture using dissociated cells or microexplants obtained from an animal organ. The method for preparing an organotypic culture comprises culturing cells from an organ on a surface characterised in that the cells are compacted. The invention further relates to a high-throughput method for the preparation of a collection of organotypic cultures. The invention further relates to a device for carrying out a method of organotypic culture according to the invention. | 2009-02-12 |
20090042289 | Preservation of Cells - The present invention relates to methods for preserving cells, in particular primary cells such as hepatocytes. In particular, the present invention relates to preserving cells within a gel comprising a hydrolysed gelatin and culturing the cells at a temperature between 0 and 15° C. | 2009-02-12 |
20090042290 | METHOD OF MODIFYING A MACROMOLECULE WITHOUT PRIOR EXTRACTION FROM A SAMPLE - The present invention encompasses a method of modifying a macromolecule without prior extraction from a sample by converting the macromolecule in the sample with a chemical, removing or converting chemical intermediates, if necessary; and purifying the resulting modified macromolecule. | 2009-02-12 |
20090042291 | Optimized Fc variants - The present invention relates to optimized Fc variants, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants. | 2009-02-12 |
20090042292 | B7-DC Variants - Compositions and methods for costimulating T cells (i.e., increasing antigen-specific proliferation of T cells, enhancing cytokine production by T cells, stimulating differentiation ad effector functions of T cells and/or promoting T cell survival) are provided. Suitable compositions include variant B7-DC polypeptides, fragments and fusion proteins thereof. Variant B7-DC polypeptides have reduced binding affinity for the inhibitory PD-1 ligand and substantially retain the ability to costimulate T cells. Methods for using variant B7-DC polypeptides to stimulate immune responses in subjects in need thereof are provided. | 2009-02-12 |
20090042293 | Cell Culture Apparatus, Cell Culture Method, Cell Culture Program and Cell Culture System - The invention intends to provide a cell culture apparatus which is able to realize an adequate culture according to the culture state of cells while alleviating the labor of an operator. The cell culture apparatus includes a culture bag for causing the cells to proliferate, a cell inoculation cassette (or culture bag as an antibody stimulating and proliferation culture vessel) for stimulating the cells by an inducer for the proliferation, a culture medium cassette for storing a culture medium supplied to the culture bag and the cell inoculation cassette, a CCD camera | 2009-02-12 |
20090042294 | Hydroxyphenyl cross-linked macromolecular network and applications thereof - A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties. | 2009-02-12 |
20090042295 | Cell culture substrate and its production method - A cell culture substrate which is durable and which can be readily produced in commercial scale at a low cost, and its production method are provided. The cell culture substrate comprises a substrate and a layer formed by surface modification, which comprises a polymer containing amino group produced by reacting a polymer represented by the following formula (II): | 2009-02-12 |
20090042296 | TRANSFECTION READY EUKARYOTIC CELLS - Described herein are frozen populations of transfection ready competent eukaryotic cells, transfection kits comprising the frozen populations of transfection ready competent cells, and methods of using the same. | 2009-02-12 |
20090042297 | Piggybac transposon-based vectors and methods of nucleic acid integration - Disclosed herein are compositions comprising integrating enzymes that can deliver nucleic acids to a target DNA. Additionally, the methods of using the compositions disclosed herein relate to treatments for a variety of infections, conditions, and genetic disorders. | 2009-02-12 |
20090042298 | COMPOSITIONS AND METHODS FOR ENHANCING DELIVERY OF NUCLEIC ACIDS INTO CELLS AND FOR MODIFYING EXPRESSION OF TARGET GENES IN CELLS - Polynucleotide delivery-enhancing polypeptides are admixed or complexed with, or conjugated to, nucleic acids for enhancing delivery the nucleic acids into cells. The transported nucleic acids are active in target cells as small inhibitory nucleic acids (siNAs) that modulate expression of target genes, mediated at least in part by RNA interference (RNAi). The siNA/polypeptide compositions and methods of the invention provide effective tools to modulate gene expression and alter phenotype in mammalian cells, including by altering phenotype in a manner that eliminates disease symptoms or alters disease potential in targeted cells or subject individuals to which the siNA/polypeptide compositions are administered. | 2009-02-12 |
20090042299 | Vectors and methods for tissue specific synthesis of proteins in eggs of transgenic hens - Vectors and methods are provided for introducing genetic material into cells of a chicken or other avian species. More particularly, vectors and methods are provided for transferring a transgene to an embryonic chicken cell, so as to create a transgenic hen wherein the transgene is expressed in the hen's oviduct and the transgene product is secreted in the hen's eggs and/or those of her offspring. In a preferred embodiment, the transgene product is secreted in the egg white. | 2009-02-12 |
20090042300 | METHOD FOR ENHANCING GENE EXPRESSION IN PLANTS - The invention relates to the field of gene expression in plants and describes methods and constructs using the first intron of a FAD2 gene in order to enhance gene expression. | 2009-02-12 |
20090042301 | TEMPERATURE REGULATED GENE EXPRESSION - A method for regulation of gene expression by variation of temperature uses a riboswitch. The riboswitch includes a 5′-UTR construct of crhC which alters its secondary structure in response to temperature, resulting in a more stable transcript at lower temperatures, permitting translation. At higher temperatures, the transcript is destabilized and functionally inactive. The 5′-UTR construct of crhC may be operatively linked to a promoter and a gene and administered to cells with an expression vector. | 2009-02-12 |
20090042302 | Isolated Polynucleotides and Methods of Promoting a Morphology in a Fungus - The invention includes isolated polynucleotide molecules that are differentially expressed in a native fungus exhibiting a first morphology relative to the native fungus exhibiting a second morphology. The invention includes a method of enhancing a bioprocess utilizing a fungus. A transformed fungus is produced by transforming a fungus with a recombinant polynucleotide molecule. The recombinant polynucleotide molecule contains an isolated polynucleotide sequence linked operably to a promoter. The polynucleotide sequence is expressed to promote a first morphology. The first morphology of the transformed fungus enhances a bioprocess relative to the bioprocess utilizing a second morphology. | 2009-02-12 |
20090042303 | METHOD FOR MEASURING THE CONCENTRATION OF A GLYCOSAMINOGLYCAN ANTICOAGULANT - The invention provides an accurate, economical, automatable, high throughput method for the determination of the concentration of glycosaminoglycan anticoagulants, including low molecular weight heparin (LMWH) anticoagulants, in aqueous solutions. A method for cleaning a unit of manufacturing equipment used in the preparation of a LMWH to obtain an acceptable residual concentration of LMWH is further provided. | 2009-02-12 |
20090042304 | METHOD FOR ANALYZING FOODS - A method for using stable isotope profiling and optionally trace element profiling to differentiate the origin of commodities, such as pistachios ( | 2009-02-12 |
20090042305 | Sensor Release Mechanism for a Test Meter - A sensor-dispensing instrument adapted to handle a sensor pack containing a plurality of sensors and to perform a test using one of the sensors. The sensor dispensing instrument includes an outer housing and a mechanical mechanism contained therein for rotating the sensor pack and ejecting one of the sensors from the sensor pack and through a sensor slot on the housing. The sensor dispensing instrument also includes a rotational-release wheel that is disposed on the outer housing of the sensor-dispensing instrument that is turnable to remove a sensor disposed in the sensor slot. | 2009-02-12 |
20090042306 | System and Method for Automatic Calibration - A device includes a sensor array and a processor is automatically calibrated. The sensor array collects data from a pattern using at least one of a capacitive measurement and a radio frequency measurement. The pattern is included on a calibration storage device. The processor receives the data from the sensor array and calibrates the device in accordance with the data. | 2009-02-12 |
20090042307 | Hydrophilic Polymer Microparticle, Filler for Ion Exchange Liquid Chromatography, and Method for Production of Filler for Ion Exchange Liquid Chromatography - An object of the present invention is to provide a hydrophilic polymer microparticle which shows reduced swelling in an aqueous medium and has an excellent dispersibility in an aqueous medium, a filler for ion-exchange liquid chromatography which can effectively suppress non-specific adsorption of protein and the like, a method for analyzing glycosylated hemoglobin using the filler for ion-exchange liquid chromatography, a method for production of a filler for ion-exchange liquid chromatography that can maintain suppressive effects on swelling, non-specific adsorption and the like for a long period of time, a filler for ion-exchange liquid chromatography produced by the method for production of a filler for ion-exchange liquid chromatography, and a filler for ion-exchange liquid chromatography for glycosylated hemoglobin analysis. | 2009-02-12 |
20090042308 | Method for isolating and modifying DNA from blood and body fluids - This invention is related to a method and assay kit for rapidly quantifying global DNA methylation through immobilizing DNA by simple dry-capture on the plastic carrier followed by immunodetection of 5-methylcytosine structure that is the marker of DNA methylation. | 2009-02-12 |
20090042309 | Breath test for total organic carbon - A total amount of volatile organic compounds (VOCs) in a breath sample ( | 2009-02-12 |
20090042310 | Particle Quantifying Systems and Methods Using Acoustic Radiation Pressure - The present invention comprises methods and systems that use acoustic radiation pressure. | 2009-02-12 |
20090042311 | ANALYTE SENSOR DEVICES AND HOLDERS, AND METHODS AND SYSTEMS UTILIZING THE SAME - Provided are sensor devices, methods, systems, and kits for measuring the concentration of at least one target analyte. Sensor devices may be mounted into an optical system for measuring the target analyte. Example sensor devices may also be removably mounted in a holder that enables the sensor device to be inserted into a container that allows the sensor device to contact an analyte containing sample. Further provided are methods that include contacting a sensor device with an analyte-containing sample; determining analyte concentration; and optionally repeating these steps to determine if the analyte concentration spikes or exceeds a predetermined level, which may trigger an alarm response. | 2009-02-12 |
20090042312 | Test method for determining compounds capable of quenching electronic singlet state excitation of photoactive compounds - A method of testing a compound for its capability of quenching singlet excited state energy from a photon-excited photoactive compound, thereby photostabilizing said photoactive compound, comprising mixing: (1) a composition comprising a photoactive compound in a solvent and determining the degree of fluorescence of said composition (1) by exposing the composition (1) to UV radiation in an amount sufficient for the photoactive compound to reach an electronic singlet excited state, and (2) a mixture comprising said photoactive compound with a test compound in a solvent, and determining the degree of fluorescence of said mixture (2) by exposing the mixture to UV radiation to the same degree as composition (1), and comparing the degree of fluorescence of composition (1) with mixture (2). | 2009-02-12 |
20090042313 | Recording assay device - The invention herein described relates to an assessment device comprising an assay part and a detachable recording part. The assessment device facilitates the rapid assaying and processing of tissue/fluid samples by healthcare workers. Also, advantageously, the result of the assay is only apparent to the healthcare worker after interrogation of the recording part at a processing facility. | 2009-02-12 |
20090042314 | LANTHANIDE-DOPED NAYF4 NANOCRYSTALS, METHOD OF PREPARING AND USES THEREOF - The present invention relates to a method of preparing lanthanide-doped NaYF | 2009-02-12 |
20090042315 | COMPOSITIONS OF SPECIFIC BINDING AGENTS TO HEPATOCYTE GROWTH FACTOR - Compositions comprising nonpolar amino acids and specific binding agents to hepatocyte growth factor (HGF) are provided. Methods of making and using such compositions are also provided. | 2009-02-12 |
20090042316 | USE OF PERFLUOROPOLYMERS IN THE DETERMINATION OF THE RECEPTOR-LIGAND BINDING CONSTANT - Use of flat surfaces comprising perfluorinated polymers in the determination of the binding constant of two interacting molecular species by using measurements of reflected light intensity, said surface comprising at least one molecule with the receptor function adsorbed or immobilized on said surface, and at least one ligand which interacts with the receptor. | 2009-02-12 |
20090042317 | SUBSTANCE IMMOBILIZING APPARATUS, SUBSTANCE DETECTING APPARATUS AND SUBSTANCE IMMOBILIZING METHOD - The efficiency of the specific binding of a target substance to an immobilization region is increased. As a first step, target substance | 2009-02-12 |
20090042318 | METHOD FOR EFFECTIVE SEARCH FOR TARGET MOLECULE - The present invention provides a solid phase carrier capable of adsorbing a highly hydrophobic target molecule, for example, a membrane associated protein, and a solid phase carrier optimized not only for a highly hydrophobic target molecule, but also for an optionally chosen target molecule. More specifically, the present invention provides a solid phase carrier having a ligand and a capping agent immobilized thereon, with the hydrophobic property of the surface thereof adjusted to enable the binding of the target molecule to the ligand, or to increase the amount of target molecule bound to the ligand; various methods using the solid phase carrier (for example, method of concentrating, isolating, or purifying a target molecule, a method of selectively adsorbing a particular target molecule to the solid phase carrier, or a method of analyzing the interaction between ligand and target molecule therefor); a production method for the solid phase carrier; and an improvement method for a solid phase carrier having a ligand and a capping agent immobilized thereon and the like. | 2009-02-12 |
20090042319 | Biosensor Detection By Means Of Droplet Driving, Agitation, and Evaporation - Methods of improving microfluidic assays are disclosed. Assays can be improved (better signal to noise ratio) by using sessile drop evaporation as an analyte concentration step (enhanced signal) and repeated passes of wash droplets as a means to reduce non-specific binding (noise reduction). In addition multiple massively parallel analyses improve the statistical precision of the analyses. | 2009-02-12 |
20090042320 | METHODS FOR LIQUID TRANSFER COATING OF THREE-DIMENSIONAL SUBSTRATES - Methods here disclosed provide for selectively coating the top surfaces or ridges of a 3-D substrate while avoiding liquid coating material wicking into micro cavities on 3-D substrates. The substrate includes holes formed in a three-dimensional substrate by forming a sacrificial layer on a template. The template includes a template substrate with posts and trenches between the posts. The steps include subsequently depositing a semiconductor layer and selectively etching the sacrificial layer. Then, the steps include releasing the semiconductor layer from the template and coating the 3-D substrate using a liquid transfer coating step for applying a liquid coating material to a surface of the 3-D substrate. The method may further include coating the 3-D substrate by selectively coating the top ridges or surfaces of the substrate. Additional features may include filling the micro cavities of the substrate with a filling material, removing the filling material to expose only the substrate surfaces to be coated, coating the substrate with a layer of liquid coating material, and removing said filling material from the micro cavities of the substrate. | 2009-02-12 |
20090042321 | APPARATUS AND METHOD FOR PLASMA DOPING - Gas supplied to gas flow passages of a top plate from a gas supply device by gas supply lines forms flow along a vertical direction along a central axis of a substrate, so that the gas blown from gas blow holes can be made to be uniform, and a sheet resistance distribution is rotationally symmetric around a substrate center. | 2009-02-12 |
20090042322 | METHOD FOR INSPECTING SEMICONDUCTOR DEVICE - According to the present invention, a method for inspecting a semiconductor device includes the steps of carrying out a first test for inspecting characteristic of semiconductor devices under a shielded (dark) condition to discriminate non-defective devices; and carrying out a second test to semiconductor devices, which have been passed the first test as non-defective devices, for inspecting characteristic of the semiconductor devices. The second test is carried out while a predetermined color of light is applied to semiconductor devices. | 2009-02-12 |
20090042323 | PROBE CARD, SEMICONDUCTOR INSPECTING APPARATUS, AND MANUFACTURING METHOD OF SEMICONDUCTOR DEVICE - A frame bonded and fixed to a back face of a probe sheet so as to surround a group of pyramid-shaped or truncated pyramid-shaped contact terminals collectively formed at a central region portion of the probe sheet on a probing side thereof is protruded from a multi-layered wiring board, and pressing force is imparted to the frame and a pressing piece at a central portion by a plurality of guide pins having spring property so as to tilt finely. | 2009-02-12 |
20090042324 | SUBSTRATE SUPPORTING APPARATUS - A substrate supporting apparatus includes first and second shafts spaced by a distance that corresponds to or exceeds a width of a substrate, and at least one wire to support the substrate. The wire has ends coupled to respective ones of the first and second shafts. The wire is raised and lowered to place a substrate onto a lower electrode in a substrate processing chamber and to remove the substrate when processing is completed. | 2009-02-12 |
20090042325 | SEMICONDUCTOR LIGHT EMITTING DEVICE AND METHOD FOR MANUFACTURING THE SAME - In a semiconductor light emitting device, a semiconductor light emitting element has a light extracted surface on which a plurality of convex structures is formed. The convex structures each have a conical mesa portion constituting a refractive index gradient structure, a cylindrical portion constituting a diffraction grating structure, and a conical portion constituting a refractive index gradient structure. The mesa portion, cylindrical portion, and conical portion are arranged in this order from the light extracted surface. The period between the convex structures is longer than 1/(the refractive index of an external medium+the refractive index of the convex structures) of an emission wavelength and equal to or shorter than the emission wavelength. The circle-equivalent average diameter of the cylindrical portion is ⅓ to 9/10 of that of the bottom of the mesa portion. | 2009-02-12 |
20090042326 | DISPLAY DEVICE AND METHOD FOR MANUFACTURING THE SAME - According to one aspect of the present invention, a laminated structure of conductive transparent oxide layers containing silicon or silicon oxide is applied as an electrode on the side of injecting a hole (a hole injection electrode; an anode) instead of the conventional conductive transparent oxide layer such as ITO. In addition, according to another aspect of the invention, a laminated structure of conductive transparent oxide layers containing silicon or silicon oxide, each of which content is different, is applied as a hole injection electrode. Preferably, silicon or a silicon oxide concentration of the conductive layer on the side where it is connected to a TFT ranges from 1 atomic % to 6 atomic % and a silicon or silicon oxide concentration on the side of a layer containing an organic compound ranges from 7 atomic % to 15 atomic %. | 2009-02-12 |
20090042327 | Method for assembling array-type semiconductor laser device - According to an aspect of the present invention, there is provided a method for assembling a semiconductor laser device, including: preparing a laser chip including: a substrate; stripe waveguides that are formed on the substrate and that each includes a gain producing area and a window area; electrodes formed on the stripe waveguides; an insulating layer formed on the electrodes; a metal layer formed on the insulating layer; projections arranged at an interval in the window areas; and joining structures connected to the electrodes and formed in the window areas; preparing a submount including: a first solder; second solders arranged at the interval; and submount electrodes connected to the second solders; contacting the laser chip to the submount by fitting the projections with respect to the second solders; and heating the submount and the laser chip. | 2009-02-12 |
20090042328 | SEMICONDUCTOR LIGHT EMITTING DEVICE - At least one recess and/or protruding portion is created on the surface portion of a substrate for scattering or diffracting light generated in a light emitting region. The recess and/or protruding portion has a shape that prevents crystal defects from occurring in semiconductor layers. | 2009-02-12 |
20090042329 | Laser Process for Reliable and Low-Resistance Electrical Contacts - Disclosed is a method for manufacturing an organic optoelectronic device. The method comprises providing a substrate, disposing a first electrode on the substrate, disposing a metal pad on the substrate, electrically separated from the first electrode, disposing a first material over the first electrode and at least partially over the metal pad, applying a beam, wherein the beam ablates the first material in an ablation window so that the ablation window includes at least a portion of an edge of the metal pad, and disposing a second electrode over the first material and over the ablation window so that the second electrode is in electrical contact with the at least a portion of an edge of the metal pad. | 2009-02-12 |
20090042330 | Etching Of Solar Cell Materials - A solar cell is fabricated by etching one or more of its layers without substantially etching another layer of the solar cell. In one embodiment, a copper layer in the solar cell is etched without substantially etching a topmost metallic layer comprising tin. For example, an etchant comprising sulfuric acid and hydrogen peroxide may be employed to etch the copper layer selective to the tin layer. A particular example of the aforementioned etchant is a Co-Bra Etch® etchant modified to comprise about 1% by volume of sulfuric acid, about 4% by volume of phosphoric acid, and about 2% by volume of stabilized hydrogen peroxide. In one embodiment, an aluminum layer in the solar cell is etched without substantially etching the tin layer. For example, an etchant comprising potassium hydroxide may be employed to etch the aluminum layer without substantially etching the tin layer. | 2009-02-12 |
20090042331 | Pinned photodiode (PPD) pixel with high shutter rejection ratio for snapshot operating CMOS sensor - A method for forming a pixel image sensor that has a high shutter rejection ratio for preventing substrate charge leakage and prevents generation of photoelectrons within a floating diffusion storage node and storage node control transistor switches of the pixel image sensor. The pixel image sensor that prevents substrate charge leakage of photoelectrons from pixel image sensor adjacent to the pixel image sensor. The pixel image sensor is fabricated on a substrate with an isolation barrier and a carrier conduction well. The isolation barrier formed underneath the floating diffusion storage node allows effective isolation by draining away the stray carriers and preventing them from reaching the floating diffusion storage node. The carrier conduction well in combination with the deep N-well isolation barrier separates the pinned photodiode region from the deep N-well isolation barrier that is underneath the floating diffusion storage node. | 2009-02-12 |
20090042332 | METHODS FOR FABRICATING A CMOS IMAGE SENSOR - A method for fabricating a CMOS image sensor includes providing a substrate having a sensor array region and a peripheral region defined thereon, forming at least a contact pad on the substrate of the peripheral region, forming a first dielectric layer covering the contact pad on the substrate, performing a first etching process to expose the contact pad and to form a step height, forming an optical shielding layer on the first dielectric layer, forming a plurality of color filters on the first dielectric layer, sequentially forming a planarizing layer and a plurality of micro-lenses on the first dielectric layer. | 2009-02-12 |
20090042333 | Structure and Method for Surfaced-Passivated Zinc-Oxide - A semiconductor device has a heterostructure including a first layer of semiconductor oxide material. A second layer of semiconductor oxide material is formed on the first layer of semiconductor oxide material such that a two dimensional electron gas builds up at an interface between the first and second materials. A passivation layer on the outer surface stabilizes the structure. The device also has a source contact and a drain contact. | 2009-02-12 |
20090042334 | CMOS image sensor and method for fabricating the same - A CMOS image sensor includes a substrate including silicon, a silicon germanium (SiGe) epitaxial layer formed over the substrate, the SiGe epitaxial layer formed through epitaxial growth and doped with a predetermined concentration level of impurities, an undoped silicon epitaxial layer formed over the SiGe epitaxial layer by epitaxial growth, and a photodiode region formed from a top surface of the undoped silicon epitaxial layer to a predetermined depth in the SiGe epitaxial layer. | 2009-02-12 |
20090042335 | VERTICAL SIDE WALL ACTIVE PIN STRUCTURES IN A PHASE CHANGE MEMORY AND MANUFACTURING METHODS - A programmable resistor memory, such as a phase change memory, with a memory element comprising narrow vertical side wall active pins is described. The side wall active pins comprise a programmable resistive material, such as a phase change material. In a first aspect of the invention, a method of forming a memory cell is described which comprises forming a stack comprising a first electrode having a principal surface with a perimeter, an insulating layer overlying a portion of the principal surface of the first electrode, and a second electrode vertically separated from the first electrode and overlying the insulating layer. Side walls on the insulating layer and on the second electrode are positioned over the principle surface of the first electrode with a lateral offset from the perimeter of the first electrode. | 2009-02-12 |
20090042336 | Fabrication method of an organic substrate having embedded active-chips - The fabrication method of an organic substrate having embedded active-chips such as semiconductor chips is disclosed. The present invention previously applies the conductive adhesives in a wafer state, makes them in a B-stage state, obtains individual semiconductor chips through dicing, and positions the individual semiconductor chips previously applied with the conductive adhesives in the cavities, making it possible to simultaneously obtain an electrical connection and a physical adhesion of the substrate and the semiconductor chips by means of a method of applying heat and pressure and stack the copper clad laminates on the upper portion of the substrate to which the semiconductor chips are connected. The present invention has advantages in processes such as a lead-free process, an environmental-friendly fluxless process, a low temperature process, ultra-fine pitch applications, etc., by mounting the active-chips through the flip chip interconnection using the non-solder bumps and the conductive adhesives. | 2009-02-12 |
20090042337 | Method of Manufacturing an Integrated Circuit Module - A method includes providing an integral array of first carriers, arranging first semiconductor chips on the first carriers, and arranging an integral array of second carriers over the semiconductor chips. | 2009-02-12 |
20090042338 | Capping Coating for 3D Integration Applications - A structure for a semiconductor component is provided having a bi-layer capping coating integrated and built on supporting layer to be transferred. The bi-layer capping protects the layer to be transferred from possible degradation resulting from the attachment and removal processes of the carrier assembly used for layer transfer. A wafer-level layer transfer process using this structure is enabled to create three-dimensional integrated circuits. | 2009-02-12 |
20090042339 | PACKAGED INTEGRATED CIRCUITS AND METHODS TO FORM A PACKAGED INTEGRATED CIRCUIT - Packaged integrated circuits and methods to form a packaged integrated circuit are disclosed. A disclosed method comprises attaching an integrated circuit to a substrate, coupling a first end of a bond wire directly to the substrate without an intervening bonding pad and a second end of the bond wire to a contact of the integrated circuit, encapsulating the integrated circuit and the bond wire, and removing the substrate to expose the first end of the bond wire. | 2009-02-12 |
20090042340 | NONVOLATILE STORAGE DEVICE AND METHOD OF MANUFACTURING THE SAME, AND STORAGE DEVICE AND METHOD OF MANUFACTURING THE SAME - A nonvolatile storage device includes a plurality of bit lines | 2009-02-12 |
20090042341 | ELECTRICAL FUSE WITH A THINNED FUSELINK MIDDLE PORTION - A metal layer is deposited on the patterned semiconductor material layer containing a cathode semiconductor portion, a fuselink semiconductor portion, and an anode semiconductor portion. The metal layer may be patterned so that a middle portion of the fuselink semiconductor portion has a thin metal layer, which upon annealing produces a thinner metal semiconductor alloy portion than surrounding metal semiconductor alloy portion on the fuselink semiconductor portion. Alternatively, a middle portion of the metal semiconductor alloy having a uniform thickness throughout the fuselink may be lithographically patterned and etched to form a thin metal semiconductor alloy portion in the middle of the fuselink, while thick metal semiconductor alloy portions are formed on the end portions of the fuselink. The resulting inventive electrical fuse has interfaces at which a thinner metal semiconductor alloy abuts a thicker metal semiconductor alloy in the fuselink to enhance the divergence of electrical current. | 2009-02-12 |
20090042342 | METHOD FOR CRYSTALLIZATION OF AMORPHOUS SILICON BY JOULE HEATING - The present invention provides a method for preparation of crystallization of amorphous silicon thin film, which comprises providing a forming a amorphous silicon on a dielectric film formed on a transparent substrate; then forming a conductive layer on the top surface of substrate; applying an electric field to the conductive layer so as to generate heat; and crystallization of amorphous silicon thin film by the generated heat. | 2009-02-12 |
20090042343 | METHODS OF FABRICATING CRYSTALLINE SILICON, THIN FILM TRANSISTORS, AND SOLAR CELLS - The present invention includes methods to crystallize amorphous silicon. A structure including a conductive film with at least one conductive layer in thermal contact with an amorphous silicon (a-Si) layer to be crystallized is exposed to an alternating or varying magnetic field. The conductive film is more easily heated by the alternative or varying magnetic field, which, in-turn, heats the a-Si film and crystallizes it while keeping the substrate at a low enough temperature to avoid damage to or bending of the substrate. The method can be applied to the fabrication of many semiconductor devices, including thin film transistors and solar cells. | 2009-02-12 |
20090042344 | InP-Based Transistor Fabrication - Methods of forming structures that include InP-based materials, such as a transistor operating as an inversion-type, enhancement-mode device. A dielectric layer may be deposited by ALD over a semiconductor layer including In and P. A channel layer may be formed above a buffer layer having a lattice constant similar to a lattice constant of InP, the buffer layer being formed over a substrate having a lattice constant different from a lattice constant of InP. | 2009-02-12 |
20090042345 | Methods of Fabricating Transistors Having Buried N-Type and P-Type Regions Beneath the Source Region - High electron mobility transistors are provided that include a non-uniform aluminum concentration AlGaN based cap layer having a high aluminum concentration adjacent a surface of the cap layer that is remote from the barrier layer on which the cap layer is provided. High electron mobility transistors are provided that include a cap layer having a doped region adjacent a surface of the cap layer that is remote from the barrier layer on which the cap layer is provided. Graphitic BN passivation structures for wide bandgap semiconductor devices are provided. SiC passivation structures for Group III-nitride semiconductor devices are provided. Oxygen anneals of passivation structures are also provided. Ohmic contacts without a recess are also provided. | 2009-02-12 |
20090042346 | Electrolyte pattern and method for manufacturing an electrolyte pattern - A method for manufacturing a gel electrolyte pattern is disclosed, the method comprising depositing an electrolyte precursor by inkjet printing onto a gelling agent layer. A gel electrolyte pattern is also disclosed, the gel electrolyte pattern comprising either a mixture of a gelling agent and an electrolyte precursor or the products of a chemical reaction between a gelling agent and an electrolyte precursor. | 2009-02-12 |
20090042347 | METHOD FOR MANUFACTURING VERTICAL MOS TRANSISTOR - A method for manufacturing a vertical MOS transistor comprising forming a protrusion-like region, forming a silicon oxide film on an exposed surface of the protrusion-like region and a surface of the silicon semiconductor substrate, increasing a film thickness of at least the silicon oxide film on the silicon semiconductor substrate by thermal oxidation to form a first insulating film, forming a lower impurity diffusion region, removing the silicon oxide film to expose a silicon side of the protrusion-like region, thermally oxidizing the silicon side to form a second insulating film having a thinner film thickness than a film thickness of the first insulating film, forming a gate electrode over a side of the protrusion-like region, and forming an upper impurity diffusion region. | 2009-02-12 |
20090042348 | METHOD FOR MANUFACTURING SEMICONDUCTOR DEVICE - In the present invention, there is provided a method for manufacturing a semiconductor device that has on a semiconductor substrate first and second transistor groups having different operating voltages respectively, the first transistor group having a first gate electrode, the second transistor group having a second gate electrode, the method including the steps of: forming the silicide layer on the first gate electrode of the first transistor group after setting a height of the first gate electrode smaller than a height of a dummy gate electrode formed in a dummy gate part; and forming a gate forming trench by removing the dummy gate part after forming an interlayer insulating film that covers a silicide layer and planarizing a surface of the interlayer insulating film. | 2009-02-12 |
20090042349 | SPLIT GATE MEMORY CELL AND METHOD THEREFOR - A split gate memory cell has a select gate, a control gate, and a charge storage structure. The select gate includes a first portion located over the control gate and a second portion not located over the control gate. In one example, the first portion of the select gate has a sidewall aligned with a sidewall of the control gate and aligned with a sidewall of the charge storage structure. In one example, the control gate has a p-type conductivity. In one example, the gate can be programmed by a hot carrier injection operation and can be erased by a tunneling operation. | 2009-02-12 |
20090042350 | MANUFACTURING METHOD OF NONVOLATILE MEMORY - A manufacturing method for a non-volatile memory includes first providing a substrate with a gate structure formed thereon. The gate structure includes a first gate and a gate dielectric layer located between the first gate and the substrate. A first doping and a second doping region are formed on the substrate at two sides of the gate, respectively. A first insulating layer is formed on the substrate, and a portion of the first insulating layer and a portion of the substrate are removed to form a trench, which divides the second doping region into a third doping region and a fourth doping region. Finally, a tunneling dielectric layer, a charge-trapping layer and a top dielectric layer are formed inside the trench, and a second gate which fills the trench is formed on the substrate. | 2009-02-12 |
20090042351 | METHOD FOR MAKING A TRANSISTOR WITH A STRESSOR - A method for forming a semiconductor device on a semiconductor material layer includes forming a gate structure over the semiconductor material layer. The method further includes forming a first nitride spacer adjacent to the gate structure and forming source/drain extensions in the semiconductor material layer. The method further includes forming an oxide liner overlying the gate structure and the source/drain extensions. The method further includes forming a second nitride spacer adjacent to the oxide liner. The method further includes forming source/drain regions in the semiconductor material layer. The method further includes using an etching process that is selective to the oxide liner, removing the second nitride spacer. The method further includes using an etching process that is selective to the first nitride spacer, at least partially removing the oxide liner. The method further includes forming silicide regions overlying the source/drain regions and the gate structure. | 2009-02-12 |
20090042352 | GATE INTERFACE RELAXATION ANNEAL METHOD FOR WAFER PROCESSING WITH POST-IMPLANT DYNAMIC SURFACE ANNEALING - Defects and fixed charge in a gate dielectric near the gate dielectric-substrate interface are reduced by performing a gate dielectric relaxation anneal step prior to source-drain ion implantation, in which the wafer temperature is ramped gradually to near a melting temperature of the substrate equal to a peak post-ion implantation anneal peak temperature. The ramping rates are sufficiently gradual so that the gate dielectric is held above its reflow temperature for a significant duration. | 2009-02-12 |