06th week of 2022 patent applcation highlights part 11 |
Patent application number | Title | Published |
20220040314 | Novel Complex Comprising A Cell Penetrating Peptide, A Cargo And A TLR Peptide Agonist - The present invention provides a novel complex comprising a) a cell penetrating peptide, b) at least one antigen or antigenic epitope, and c) at least one TLR peptide agonist, wherein the components a)-c) are covalently linked. Moreover, the present invention also provides a nucleic acid encoding such a complex, wherein the complex is a peptide or a protein. Such a nucleic acid may be comprised by a vector, and such a vector may be comprised by a host cell. In particular, compositions, such as a pharmaceutical compositions and vaccines are provided, which may be useful for example in the prevention and/or treatment of a diseases and/or a disorder including cancer, hematological disorders, infectious diseases, autoimmunity disorders and transplant rejections. | 2022-02-10 |
20220040315 | NUCLEASE-DENDRIMER FORMULATIONS FOR COVID-19 AND BROAD-SPECTRUM ANTIVIRAL THERAPY AND PROPHYLAXIS - Compositions of nucleases in formulations with dendrimers are used in pharmaceutically effective dosages as therapeutics for covid-19 and a broad spectrum of viruses in various embodiments. When cationized nucleases are mixed and/or complexed with a dendrimer, an unexpected positive dendrimer effect is manifest. This positive dendrimer effect is shown to be highly effective for catalyzing anti-viral RNase properties. In various embodiments compositions of cationized nucleases in combination with a dendrimer demonstrated this synergistic amplification of anti-viral effectiveness and are used in pharmaceutically effective dosages as therapeutics against covid-19 and a broad spectrum of viruses. An exemplar formulation which exhibits a positive dendrimer effect is cationized RNase A mixed and/or complexed with gen 2 PAMAM dendrimer. | 2022-02-10 |
20220040316 | TRIPLE COMBINATION THERAPIES FOR TARGETING MITOCHONDRIA AND KILLING CANCER STEM CELLS - Cancer stem cells (CSCs) may be eradicated through a novel therapeutic strategy involving, in some embodiments, FDA-approved antibiotics and dietary supplements. The present approach effectively results in the synergistic eradication of CSCs through inhibiting mitochondrial biogenesis in CSCs during induced mitochondrial oxidative stress, without inhibiting normal cells. Embodiments may include a therapeutic agent that inhibits mitochondrial biogenesis and targets the large mitochondrial ribosome, a therapeutic agent that inhibits mitochondrial biogenesis and targets the small mitochondrial ribosome, and a therapeutic agent that behaves as a pro-oxidant or induces mitochondrial oxidative stress. Compositions according to the present approach inhibited CSC propagation by ˜90% in MCF7 ER(+) cell lines during preliminary studies, with confirmed reduction in mitochondrial oxygen consumption and ATP production. Some embodiments include sub-antimicrobial antibiotic concentrations, thereby minimizing antibiotic resistance concerns. In some embodiments, one or more therapeutic agents are conjugated with a targeting signal. | 2022-02-10 |
20220040317 | DEGRADATION OF FAK OR FAK AND ALK BY CONJUGATION OF FAK AND ALK INHIBITORS WITH E3 LIGASE LIGANDS AND METHODS OF USE - Disclosed are bifunctional compounds (degraders) that target FAK or FAK and ALK for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the compounds to treat disease. | 2022-02-10 |
20220040318 | PRIMARY AMINE COMPOUND OR SECONDARY AMINE COMPOUND-ACIDIC POLYSACCHARIDE CONJUGATE AND PRODUCTION METHOD THEREFOR - Provided is a novel conjugate of a primary or secondary amine compound with an acidic polysaccharide, which is a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof, where in Formula (I), D, R | 2022-02-10 |
20220040319 | METHODS OF TREATING OCULAR CANCER USING ANTI-MET ANTIBODIES AND BISPECIFIC ANTIGEN BINDING MOLECULES THAT BIND MET - Provided herein are methods of treating ocular cancer such as uveal melanoma, orbital lymphoma, retinoblastoma, and medulloepithelioma using antibodies and bispecific antigen-binding molecules that bind MET or antibody-drug conjugates (ADCs) comprising the antibodies or bispecific antigen-binding molecules. The bispecific antigen-binding molecules comprise a first and a second antigen-binding domain, wherein the first and second antigen-binding domains bind to two different epitopes of the extracellular domain of human MET. The ADCs comprise the antibodies or bispecific antigen-binding molecules provided herein linked to a cytotoxic agent, radionuclide, or other moiety. The antibodies and bispecific antigen-binding molecules are capable of blocking the interaction between human MET and its ligand HGF. A subject having ocular cancer, for example, an uveal melanoma expressing c-Met, can be treated by administering to the subject an antibody, a bispecific antigen-binding molecule, or an ADC thereof. | 2022-02-10 |
20220040320 | ADCS WITH THIOL MULTIPLEX LINKERS - The present disclosure provides, inter alia, thiol multiplexed Antibody Drug Conjugates (TM-ADCs) and Multiplex Linking Assemblies (MLAs) that comprise multiple Drug Moieties in a single linking assembly. | 2022-02-10 |
20220040321 | PROCESS FOR PREPARING ANTIBODY-DRUG CONJUGATES WITH IMPROVED HOMOGENEITY - Provided herein is an applicable bio-conjugation process for preparing antibody-drug conjugates (ADCs) with improved homogeneity. As compared with conventional conjugation process, the homogeneity of antibody-drug conjugate (ADC) products generated from the bio-conjugation process can be dramatically improved. Specifically, in the ADCs prepared by the process disclosed herein, the content of D0+D8 is less than 10 wt % and the content of D6 is less than 10 wt %. Moreover, the content of D4 is generally more than 65 wt %, for example, more than 70 wt %, and more than 77 wt %, while the content of D4 is normally less than 40 wt % in the ADCs prepared by conventional conjugation processes. | 2022-02-10 |
20220040322 | COMPOSITIONS AND METHODS OF TREATING MUSCLE ATROPHY AND MYOTONIC DYSTROPHY - Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating muscle atrophy or myotonic dystrophy. | 2022-02-10 |
20220040323 | COMPOSITIONS AND METHODS OF TREATING MUSCLE ATROPHY AND MYOTONIC DYSTROPHY - Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating muscle atrophy or myotonic dystrophy. | 2022-02-10 |
20220040324 | COMBINATION OF ANTIBODY-DRUG CONJUGATE AND KINASE INHIBITOR - A pharmaceutical composition wherein an antibody-drug conjugate in which a drug-linker of the represented formula (wherein A represents a connecting position to an antibody) is conjugated to the antibody via a thioether bond and a kinase inhibitor (at least one selected from the group consisting of a CDK4/6 inhibitor, an mTOR inhibitor, a PI3K inhibitor, an AKT inhibitor, an ERK inhibitor, an MEK inhibitor, an RAF inhibitor, a CDK1 inhibitor, a CDK2 inhibitor, a CHK1 inhibitor, a WEE1 inhibitor, a PLK1 inhibitor, an Aurora kinase inhibitor, a Bcr-Abl inhibitor, an Src inhibitor, an EPH inhibitor, a VEGFR inhibitor, a KIT inhibitor, an RET inhibitor, a PDGFR inhibitor, an FGFR inhibitor, a BTK inhibitor, an FLT3 inhibitor, an ALK inhibitor, a JAK inhibitor, an MET inhibitor, a CSF-1R inhibitor, an NTRK inhibitor, an EGFR inhibitor, and an HER2 inhibitor) are administered in combination, and/or a method of treatment. | 2022-02-10 |
20220040325 | LIPID NANOPARTICLES FOR IN-VIVO DRUG DELIVERY, AND USES THEREOF - The present invention relates to lipid nanoparticles for in vivo drug delivery and uses thereof, and the lipid nanoparticle are liver tissue-specific, have excellent biocompatibility and can deliver a gene therapeutic agent with high efficiency, and thus it can be usefully used in related technical fields such as lipid nanoparticle mediated gene therapy. | 2022-02-10 |
20220040326 | AAV-MEDIATED SUBCELLULAR TARGETING OF HETEROLOGOUS RHODOPSINS IN RETINAL GANGLION CELLS - Microbial type rhodopsins, such as the light-gated cation-selective membrane channel, channelrhodopsin-2 (Chop2/ChR2) or the ion pump halorhodopsin (HaloR) are expressed in retinal ganglion cells upon transduction using recombinant AAV vectors. Selective targeting of these transgenes for expression in discrete subcellular regions or sites is achieved by including a sorting motif in the vector that can target either the central area or surround (off-center) area of these cells. Nucleic acid molecules comprising nucleotide sequences encoding such rhodopsins and sorting motifs and their use in methods of differential expression of the transgene are disclosed. These compositions and methods provide significant improvements for restoring visual perception and various aspects of vision, particular in patients with retinal disease. | 2022-02-10 |
20220040327 | COMPOSITIONS AND METHODS FOR TREATING NON-AGE-ASSOCIATED HEARING IMPAIRMENT IN A HUMAN SUBJECT - Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject. | 2022-02-10 |
20220040328 | MULTIGENE CONSTRUCT FOR IMMUNE-MODULATORY PROTEIN EXPRESSION AND METHODS OF USE - Provided are expression vector constructs encoding IL-12 p35 and IL-12 p40 proteins where each protein or component thereof can be expressed utilizing appropriate promoters and/or translation modifiers. Also provided are methods of use for the expression vectors. | 2022-02-10 |
20220040329 | INDUCIBLE EXPRESSION CASSETTE, AND USES THEREOF - An expression cassette including a gene of interest under the control of an inducible promoter, characterized in that said inducible promoter includes at least one CARE regulatory sequence (C/EBP-ATF responsive element) and a minimal promoter. Also, a vector and a host cell, as well as to a pharmaceutical composition including such a cassette, and to the use thereof for treating diseases by gene therapy. | 2022-02-10 |
20220040330 | LIPID NANOPARTICLE COMPOSITIONS AND METHODS FOR MRNA DELIVERY - Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies. | 2022-02-10 |
20220040331 | COMPOSITIONS AND METHODS FOR TRANSFECTING CELLS - The present disclosure relates to branched polymers and polyplexes which find use in gene therapy applications as safe and non-toxic nucleic acid transfection agents. | 2022-02-10 |
20220040332 | GENE THERAPY FOR TREATING FAMILIAL HYPERCHOLESTEROLEMIA - Regimens useful treating a human patient having familial hypercholesterolemia are described. Such regimens comprise co-administration of corticosteroids with a suspension of replication deficient recombinant adeno-associated virus (rAAV) comprising LDLR. | 2022-02-10 |
20220040333 | Use of neuroglobin agonist for preventing or treating mitochondrial RCCI and/or RCCIII deficiency disease - The present invention concerns a neuroglobin agonist for use in the treatment or prevention of a mitochondrial disease associated with respiratory chain complex I (RCCI) deficiency and/or respiratory chain complex III (RCCIII) deficiency. | 2022-02-10 |
20220040334 | HIGH-THROUGHPUT SCREENING METHODS OF SENESCENCE-ANTAGONIZING SUBSTANCES AND SYSTEMS THEREOF - A method and system for screening candidate substances or compositions thereof, where mammalian cells containing a stain or detectable marker are introduced into the yolk sac of a fertilized egg, embryo, or larvae of a transparent and/or translucent fish model. The method and system may also be employed to identify detectable marker genes, marker proteins, or marker metabolites in the transplanted mammalian cells, where the marker may indicate, e.g., cellular senescence, non-senescence, excessive or abnormal proliferation, damaged DNA. Methods of treating a subject suffering from a disease, disorder, or condition resulting from cellular senescence, excessive or abnormal proliferation, or damaged DNA using the candidate substances or compositions thereof are provided. | 2022-02-10 |
20220040335 | RADIOLABELED PABA AND DERIVATIVES THEREOF FOR USE AS FUNCTIONAL RENAL IMAGING AGENTS - The present invention provides positron emitter radiolabeled versions of PABA, metabolites and derivatives, with good radiochemical yield, high specific activity, high chemical and radiochemical purity and having excellent characteristics for PET imaging. The inventive composition and methods provide high quality dynamic images of the kidneys while reducing the radiation exposure. The short biological half-life of PABA, added to the short physical half-life of positron emitters such as | 2022-02-10 |
20220040336 | HETEROBIARYL COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN - Provided herein are certain compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use. | 2022-02-10 |
20220040337 | RADIOLIGANDS FOR PRETARGETED PET IMAGING AND METHODS OF THEIR THERAPEUTIC USE - Described herein are Tz/TCO-based pretargeting strategies using an Al[ | 2022-02-10 |
20220040338 | Alpha Emitter Compositions And Methods - Compositions, methods, and uses of an alpha emitter are provided in which the alpha emitter is coupled to carrier protein via a cleavable coupling moiety. The coupling moiety is preferably cleavable in an acidic tumor microenvironment, and as such will enrich the alpha emitter upon cleavage within the tumor microenvironment. | 2022-02-10 |
20220040339 | CXCR4-TARGETED DIAGNOSTIC AND THERAPEUTIC AGENTS WITH REDUCED SPECIES SELECTIVITY - The present disclosure relates to imaging and endoradiotherapy of diseases involving chemokine receptor 4 (CXCR4). Provided are compounds which bind or inhibit hCXCR4 and mCXCR4 and furthermore carry at least one moiety which is amenable to labeling. Provided are also medical uses of such compounds. | 2022-02-10 |
20220040340 | RADIOLABELED MELANOCORTIN 1 RECEPTOR-SPECIFIC ALPHA-MELANOCYTE-STIMULATING HORMONE ANALOGUES FOR IMAGING OR THERAPY - A compound is provided comprising a melanocortin 1 receptor (MC1R) targeting peptide (MC1RTP), a radiolabeling group, and a linker joining the MC1RTP to the radiolabeling group. The MC1RTP is linear or cyclized, and comprises a sequence of Formula I or Formula II: Xaa | 2022-02-10 |
20220040341 | TREATMENT AND AGITATION DEVICE FOR ULTRAVIOLET, TEMPERATURE AND GASEOUS CONTROLLED STERILIZATION, CURING AND TREATMENT OF AGRICULTURAL PRODUCTS INCLUDING CANNABIS, AND METHODS FOR TREATMENT - An ultraviolet light sterilization device for treatment of plant materials, having a rotational treatment chamber having an axis of rotation and at least one mechanical agitation element, an ultraviolet light device that is positioned inside the rotational treatment chamber and is further positioned generally parallel to and congruent with the axis of rotation and where the ultraviolet light device and the rotational treatment chamber are connected to one another via a rotational bearing such that the rotational treatment chamber may be rotated about the axis of rotation while the ultraviolet light device does not rotate, and where the ultraviolet light device is electrically coupled to a power source via an electrical cable that passes through an aperture in the rotational bearing. | 2022-02-10 |
20220040342 | SOLAR-HEATED THERMO-CHEMICAL DECONTAMINATION SYSTEMS FOR FACEMASKS OR OTHER PERSONAL PROTECTION EQUIPMENT (PPE) - A system includes a containment vessel configured to receive and hold one or more pieces of personal protection equipment to be heated and decontaminated during a decontamination process. The system also includes a solar collection device configured to heat the containment vessel based on received solar energy. The solar collection device includes a body having a first portion and a second portion. The first portion includes a solar aperture configured to receive the solar energy. The second portion is configured to receive the containment vessel within the body of the solar collection device. The solar collection device also includes louvered slats across the solar aperture. The louvered slats are configured to be rotated in order to control an amount of solar energy passing through the solar aperture into the body of the solar collection device. | 2022-02-10 |
20220040343 | ULTRAVIOLET LED LIGHT SANITIZER AND DEVICES SANITIZED THEREBY - A portable sanitizing system for rapidly dispensing reusable finger coverings for handling contaminated surfaces in a sanitary fashion. A battery operated ultraviolet LED system sanitizes finger coverings which are customized for use with the sanitizing device. The sanitary finger coverings can be rapidly applied to the user's hand without contamination, using a single hand. Repeated sanitization and utilization are similarly rapid and easy. The sanitizer can be carried by the user or attached to their uniform. The reusable finger covers can be custom fit to a variety of hand sizes and are optimally designed to work with the sanitizing device. The implement aids in grasping surfaces securely without touching the surface with the user's bare fingers. | 2022-02-10 |
20220040344 | METHOD FOR INACTIVATING BACTERIA OR VIRUSES AND INACTIVATING APPARATUS FOR BACTERIA OR VIRUSES - Provided are a method and an apparatus for inactivating bacteria or viruses attached to an object while suppressing generation of a strange odor. The method for inactivating bacteria or viruses includes a step (a) of irradiating with ultraviolet light having an optical output at a specific wavelength in a range of 200 nm to 235 nm. The step (a) is a step of irradiating with the ultraviolet light is performed so that an irradiance (X) [mW/cm | 2022-02-10 |
20220040345 | APPARATUS AND METHOD FOR PREVENTING BIOFOULING IN HVAC DRAIN SYSTEMS - The invention provides a solution for biofouling in HVAC condensate drain systems, including drain pans and drain lines, using ultraviolet (UV) radiation. Embodiments of the invention include one or more of: one or more ultraviolet (UV) radiation sources, positioning mechanisms for the UV radiation sources, and one or more UV radiation source control systems. Specific location of the UV radiation source control system(s) can be proximal to the UV radiation sources, or located remotely. | 2022-02-10 |
20220040346 | SYSTEM AND METHOD FOR SHOPPING CART DISINFECTION AND STERILIZATION USING ULTRAVIOLET LIGHT - A system and method for sterilizing one or more high-touch implements, such as shopping carts, using ultraviolet (UV) light within a contained chamber for a specified period of time. In an embodiment, one or more shopping carts may be guided into a sterilization chamber through a front-side opening of an apparatus. Once the shopping cart is in place inside the sterilization chamber, a UV light process may be engaged whereby several UV lights will be turned on to flood the sterilization chamber with UV light. UV light has been shown to be effective at killing bacteria, viruses, mold, and other pathogens with exposure in as little as 5 seconds. The sterilization procedures results in sterilizing a shopping cart for next use as sterilized carts may be collected in a corral designated form newly sterilized shopping intended for next use. | 2022-02-10 |
20220040347 | System and method for cleaning and disinfecting shopping carts - The present invention provides a system and method for cleaning and disinfecting shopping carts. The system comprises a main housing with three main systems: a steam system, an ultraviolet system and a microwave system. The combination of the systems allows for the reduction of germs and viruses without the use of chemicals which may be both harmful to the shopping carts and to the environment. A conveying means allows shopping carts to be displaced through the system. The system further provides a disinfecting box in connection with the main housing for users to disinfect their hands. The method provided allows for the cleaning and disinfecting of a shopping cart with the use of the system. | 2022-02-10 |
20220040348 | METHOD, APPARATUS AND SYSTEM FOR DISINFECTING AIR AND/OR SURFACES - To provide a method for disinfecting air and/or surfaces which can be carried out truly continuously, in particular for essentially 24 hours a day, with people and/or animals present, the a method for disinfecting air and/or surfaces is proposed, wherein a disinfectant is dispersed continuously into a volume and/or area to be disinfected, wherein the disinfectant comprises electrolyzed and/or sterilized water containing hypochlorous acid, and wherein the disinfectant is dispersed at a dispersion rate between 0.5 ml/m | 2022-02-10 |
20220040349 | ANTIVIRAL METHODS AND COMPOSITIONS - A method of inactivating an enveloped ssRNA virus, such as SARS-CoV-2. The method involves contacting the enveloped ssRNA virus with an antiviral polyelectrolyte compound and/or a conjugated aromatic compound effective to inactivate the virus. The disclosure also provides a method of reducing the period of viability of enveloped ssRNA virus, such as SARS-CoV-2, on personal protective equipment, in air, in water, and/or on surfaces that have come into contact with the virus. | 2022-02-10 |
20220040350 | Instrument disinfection - Instrument disinfecting apparatus and method. The instrument disinfecting apparatus includes a first nozzle sized to be positioned with respect to an instrument to at least partially disinfect the instrument, a first hose configured to operably connect with the first nozzle, and a disinfectant generator. The disinfectant generator is configured to operably connect with the first hose and emit a disinfectant agent into the first hose so that the disinfectant agent travels through the first hose and exits the first nozzle to at least partially disinfectant the instrument. | 2022-02-10 |
20220040351 | Disinfection apparatus and method - Disinfecting apparatus and method. The disinfecting apparatus includes a first nozzle sized to be positioned with respect to a surface to disinfect the surface, a first hose configured to operably connect with the first nozzle, and a disinfectant generator. The disinfectant generator is configured to operably connect with the first hose and emit a disinfectant agent into the first hose so that the disinfectant agent travels through the first hose and exits the first nozzle to disinfectant the surface. | 2022-02-10 |
20220040352 | SANITIZING UVC LIGHTING SYSTEM - A system or kit for distributing UVC light in an environment occupied by humans generally comprises a fiber optic cable, a UVC light assembly that couples to the fiber optic cable and emits a wavelength of 200-250 nm, and a flexible plastic tube that receives and carries the light and distributes the UVC light through its outer surface. UVC light issues from multiple locations along the length of the flexible plastic tube at varied angles toward surfaces in the light's path to disinfect the surfaces and intervening air. The UVC light does not penetrate the outer layer of human skin. One light source may feed multiple flexible plastic tubes, which may have light-emitting perforations and a flat side shaped to aid mounting on many surfaces. An outer finish on the flexible plastic tube may enhance dispersion of the emitted UVC light. | 2022-02-10 |
20220040353 | DEODORANT-CONTAINING WORKING FLUID, METHOD FOR MANUFACTURING DEODORIZING PRODUCT, DEODORIZING FILTER MEDIUM, DEODORIZING FILTER UNIT, AND DEODORIZING DEVICE - The present deodorant-containing processing liquid includes an acid salt of an aminoguanidine, an inorganic carrier capable of carrying the acid salt of the aminoguanidine, a dispersant, and water, a content of the acid salt of the aminoguanidine is 15 parts or more by mass based on 100 parts by mass of a content of the inorganic carrier, and the dispersant is at least one selected from a group consisting of an anionic surfactant and a nonionic surfactant. | 2022-02-10 |
20220040354 | CORONAVIRUS (COVID-19) AIR SANITIZATION/ISOLATION SYSTEM WITH ANTI-VIRUS CURTAIN WALLS - Various embodiments are directed to a coronavirus air sanitization/isolation system with anti-virus curtain. The system may include a group of anti-virus strips with attached separation magnets coupled to an air inlet housing mounted above (e.g., in an attic ceiling) in an enclosed space. The anti-virus strips may be coated with a saline and soap solution that attracts airborne droplets contaminated with the coronavirus and dissolves a fatty layer of coronavirus cell membranes to prevent cell replication of the coronavirus, thereby destroying the coronavirus. The air inlet housing may include exhaust ventilation fans, salt filters, a wick saturated with the saline and soap solution, an electro-static air filter, and a distribution air duct. The fans may be utilized to circulate an airstream containing the coronavirus through the anti-virus strips, the filters, the saturated wick, and the distribution air duct to remove the coronavirus while protecting occupants with uncontaminated air. | 2022-02-10 |
20220040355 | WIRELESS DISINFECTION DEVICE - A wireless disinfection device, comprising a housing with a grip hole and a through hole. A spraying unit is fitted to the through hole. An air-intake motor, a liquid delivery tube, a nozzle unit and a liquid storage unit are disposed within the housing. A first tube end of the nozzle unit is connected to the spraying unit. A second tube end of the nozzle unit is connected to an air outlet tube of the air-intake motor. A third tube end of the nozzle unit is fitted downwardly to the liquid storage unit. The liquid delivery tube extends from the liquid storage unit and enters into the nozzle unit. The spraying unit includes a nozzle structure. After the air-intake motor is driven, the air can be blown into the nozzle unit such that each tube end of the nozzle unit generates an airflow pressure difference, thereby shooting an disinfecting liquid in the liquid storage unit to a first spray end of the nozzle structure located outside the nozzle orifice. Then, the high-pressure jet is directed to a second spray end of the nozzle structure outside the nozzle orifice such that the air and the disinfecting liquid are combined outside the nozzle orifice to achieve the spray disinfection. | 2022-02-10 |
20220040356 | SPACE CLEANING SYSTEM AND SPACE CLEANING METHOD - A space cleaning system includes: a detection unit configured to detect generation and a generation position of an infectious substance in a space; an airflow control unit configured to generate an airflow towards the generation position detected in response to detection of the generation of the infectious substance; and a cleaning control unit configured to clean the space at least after the generation of the infectious substance is detected. | 2022-02-10 |
20220040357 | Photocatalytic sanitizing reactor - A sanitizing photocatalytic reactor suitable for air liquid or liquid fluids includes a reaction region containing a photocatalyst selected from nanotechnological materials of natural light photocatalyst type, which is supported on an inert support or mixed with a plastic material, and an illumination region having white color LED lights, the reaction region further having one or more channels through which the fluids to be sanitized flow. | 2022-02-10 |
20220040358 | Ultra-v mask - As the human population continues to grow and evolve so are the viruses and bacterium. Our modern world is becoming a more complex and hazardous environment as time moves on. Through technology we must create counter measures to combat this growing threat. One such measure is the creation of the Ultra-V Mask. This mask is state of the art and like none other. My personal protection device treats the air you inhale and exhale with uniquely designed baffled chambers that utilize UVC light as a sterilization method limiting if not eliminating the risk of transmission of harmful microbes to the user or others. As a result The Ultra-V Mask may very well save your life and lives of others. | 2022-02-10 |
20220040359 | UV-C Room Air Sanitizer Light Box - Wall-mounted UV-C sanitizer light box has ultraviolet lamp elements and a cover or shade movable between operating positions. In a closed position in the lamp elements are covered. In an optional intermediate position the lamp elements can emit ultraviolet to the upper part of the room space above head level. In a full open position room surfaces and furniture in the room are exposed to germicidal irradiation. The unit is fully programmable as to mode of operation and duration. Sensors can shut the unit off if persons are present or motion is detected in the room space during sanitizing. An indicator light show the status of the arrangement, i.e., whether the most recent sanitization operation was completed successfully. The shade may have built-in louvers, wherein an upper room air sanitization operation can occur with the shade in the raised or closed condition. | 2022-02-10 |
20220040360 | PORTABLE AIR STERILIZER WITH OXYGEN GENERATOR - A personal protective wearable air sterilizing apparatus is comprised of a series of looped internal conduits, designed in such a way to allow total internal reflection of UV light, and the simultaneous sterilization of atmospheric air. The apparatus has oxygen generator using electrolysis of water and neutralizes hydrogen gas derived from the process to an inert compound such as hydrogen peroxide; or reuses the hydrogen to generate electricity. | 2022-02-10 |
20220040361 | Projection of germicidal ultra-violet light by edgelit substrate - A novel purification device is provided which projects Ultra-Violet wavelength light to create curtain-like beams that impair germs and pathogens exposed thereto or passing through the beams. A preferred embodiment described herein is comprised of a powered Light Emitting Diode to produce light, mounted edgelight-fashion onto an optically clear substrate light guide that has clear remote outer edges for light projection. Substrate utilized herein is an optically clear sheet such as acrylic that guides the edge-mounted L.E.D. produced Ultra-Violet wavelength light to its remote edges, projecting it outwardly through surrounding air and onto surfaces in light beams emitting from edges of the substrate, projected in suitable strength and wavelength UV-C to create a curtain-like partition, a barrier deadly to airborne or surface germs, and renders germs exposed to the light dead, damaged or inert. | 2022-02-10 |
20220040362 | DUAL-MODE SANITZER - A sanitizer may operate in two modes and in its primary mode include a UVC lamp, enclosed by a base with electronic components, a shroud with fan and filter attached, to cover the UVC lamp. The shroud may have inlet holes at one end thereof. When the fan is turned on, air may be drawn in from the exterior through the inlet holes of the shroud. The fan may continue to direct the drawn in air through the filter, across the UVC lamp, and then back to the exterior of the sanitizer. Thus, the air may be filtered of ozone and cleansed of pathogens, even when in the presence of room occupants. To operate in its secondary mode, the sanitizer would have the above-described shroud removed to emit UVC light directly to sanitize both air and surfaces simultaneously in a space without occupants. | 2022-02-10 |
20220040363 | Systems and Methods for Air Treatment Using UV Irradiation - An air treatment system includes an enclosure, a first UV lamp, a second UV lamp, and one or more air driving components. The enclosure includes an inlet, an outlet, and a passageway between the inlet and the outlet. The one or more air driving components are configured to draw air into the enclosure via the inlet, and to direct air toward the outlet via the passageway. The first UV lamp is configured to output first UV light having a first peak wavelength, and the second UV lamp is configured to output second UV light having a second peak wavelength that is different from the first peak wavelength. The first and second UV lamps are disposed in the enclosure, and each of the first light and the second light irradiates the passageway. A method of operating the air treatment system is also disclosed. | 2022-02-10 |
20220040364 | Systems for Avoiding Contamination and Accumulation of Airborne Pathogens - In one embodiment, systems and methods for reducing infections from a pathogen by influencing transport of the pathogen. A material is positioned in a location where a pathogen may be transmitted from a person and through a volume of air about the person. The material is provided with a net electric charge sufficient to create a measurable electric field extending from the material. To the extent the pathogen becomes positioned along a portion of the material, a treatment is applied about the material portion to disable the infectious nature of the pathogen. | 2022-02-10 |
20220040365 | AIR DISINFECTION CHAMBER - A system disinfects air. The system includes an elongated chamber having an inlet configured for air to flow into the chamber. The chamber also has an outlet configured for air to flow out of the chamber, and a sidewall formed from a material that is at least 90% UVC reflective. The chamber defines a longitudinal axis. A LED is positioned to emit UVC radiation in a direction substantially perpendicular to the longitudinal axis of the chamber. A filter is configured to trap pathogens. The filter is formed of a material that is UVC reflective and UVC transmissive. | 2022-02-10 |
20220040366 | Multi-Mode Lighting Device - A multi-mode lighting device includes a visible light source configured to emit a visible light and a controlling mechanism. The controlling mechanism is configured to operate the lighting device in at least two operational modes: a regular mode and a therapeutic mode. In the regular mode, the controlling mechanism operates the visible light source for general illumination. In the therapeutic mode, the controlling mechanism is configured to either flash the visible light source at a frequency in a frequency range of 35˜45 Hz or generate an audible sound at a frequency in a frequency range of 35˜45 Hz, or both. Some embodiments may support additionally a germicidal lighting mode, and some other embodiments with continuous photocatalyst-based air filtering and sanitization. | 2022-02-10 |
20220040367 | PACKAGING SOLUTIONS - A packaging system for the storage of an ophthalmic device is disclosed. The packaging system comprises a sealed container containing one or more unused ophthalmic devices immersed in an aqueous packaging solution comprising (a) one or more osmoprotectants, (b) one or more poloxamer comfort agents and (c) one or more polyol demulcents, wherein the aqueous packaging solution has an osmolality of at least about 150 mOsm/kg, a pH of about 6 to about 9 and is heat sterilized. | 2022-02-10 |
20220040368 | ODOR/TOXIN-ABSORBING SANITARY PADS, PANTY LINERS, AND TAMPONS - An odor and menses absorption device includes a user contact layer and at least one adjoining super absorbent core layer. Fluid can move from the user contact layer to the super absorbent core layer. The user contact layer contains a blend of polylactic acid fiber and bamboo charcoal fiber and acts as a barrier to fluids with a surface tension greater than 30 dynes. | 2022-02-10 |
20220040369 | MEDICAL ARTICLE WITH BACKING - Aspects of the present disclosure relate to an article that includes a conformable backing having first and second opposed major surfaces. The conformable backing can be formed from a thermoplastic polymer selected from a group consisting of polyurethanes, polyesters, and combinations thereof. The conformable backing has a tensile strength of no greater than 60 grams per centimeter force at 25% elongation in a machine direction according to the Tensile and Elongation Test Method. A hydrophobic adhesive can be disposed on a portion of the first major surface of the conformable backing. The hydrophobic adhesive includes a cationic, bioactive agent, a hydrophobic solubilizer capable of solubilizing at least part of the bioactive agent, and a hydrophobic plasticizing agent having a weight average molecular weight of above 1500. | 2022-02-10 |
20220040370 | ULTRA-LIGHT WEIGHT HEMOSTATIC MICROSPHERES - A hemostatic composition comprises a powder of a plurality of hollow or highly-porous microparticles that exhibit hemostatic properties, wherein each of the microparticles comprise a body comprising a clay material that is a crystalline hydrated form of a layered silicate. | 2022-02-10 |
20220040371 | PHOTOACTIVATED CROSSLINKING OF A PROTEIN OR PEPTIDE - A method of crosslinking a protein or peptide for use as a biomaterial, the method comprising the step of irradiating a photoactivatable metal-ligand complex and an electron acceptor in the presence of the protein or peptide, thereby initiating a cross-linking reaction to form a 3-dimensional matrix of the biomaterial. | 2022-02-10 |
20220040372 | DEVICE FOR GUIDED BONE REGENERATION AND PRODUCTION METHOD - The present invention relates to a device for guided bone regeneration, intended for the reconstruction of a buccal bone defect, composed of zirconium dioxide and having a shape which covers said buccal bone defect. The present invention also relates to a method for producing a device of the invention, comprising a step of constructing the device of the invention according to a three-dimensional representation obtained by means of a technique of maxillo-dental imaging of the bone defect. | 2022-02-10 |
20220040373 | UV ABSORBING OCULAR LENS - Ocular lenses having UV absorbing properties are disclosed. The ocular lens comprises a hydrogel polymer comprising polymerised residues derived from a polymerisable UV absorber of formula (I): | 2022-02-10 |
20220040374 | CROSSLINKED HYALURONIC ACID, HYALURONIC ACID HYDROGEL, AND METHOD FOR PRODUCING CROSSLINKED HYALURONIC ACID AND HYALURONIC ACID HYDROGEL - Provided are a crosslinked hyaluronic acid product in the form of powder and a method of preparing the same, and a crosslinked hyaluronic acid hydrogel prepared using the crosslinked hyaluronic acid product in the form of powder, and a method of preparing the same. The crosslinked hyaluronic acid hydrogel according to the present disclosure exhibits excellent rheological properties, and mass production thereof is easy and quality uniformity thereof is excellent. | 2022-02-10 |
20220040375 | METHOD OF COATING MEDICAL IMPLANTS WITH HYDROXYAPATITE AND DEVICE FOR IMPLEMENTING THE SAME - A method of coating a medical implant with hydroxyapatite comprises steps of: (a) plasma treating said medical implant by a plasma electrolytic oxidation bath within an electrolyte; (b) hydroxyapatite coating a plasma treated medical implant in a hydrothermal pressurized reactor; (c) washing a hydroxyapatite coated medical implant; and (d) drying a washed medical implant. At least one of steps a and b further comprises a sub-step of forming crystallization seeds on a surface of said medical implant. | 2022-02-10 |
20220040376 | DECELLULARIZED NERVE ALLOGRAFTS - This document relates to decellularized nerve allografts. For example, decellularized nerve allografts and methods and materials for using decellularized nerve allografts to repair nerve injuries or bridge a severed nerve are provided. | 2022-02-10 |
20220040377 | LASER ABLATION/REMOVAL AND LASER INDUCED FORWARD TRANSFER OF BIOLOGICAL MATERIAL - A method for cell printing is disclosed. The method includes generating a receiver substrate, ablating or removing a portion of the receiver substrate via a first laser to expose a target layer, generating a donor substrate containing a back surface and a front surface, applying a coating of donor material to the front surface. The method further includes aligning the front surface of the donor substrate to be parallel to and facing the receiver substrate, wherein the donor material is disposed adjacent to the target layer, and irradiating the coating through the back surface of the donor substrate with one or more laser pulses produced by a second laser to transfer a portion of the donor material to the target layer. A system for cell printing is also disclosed. | 2022-02-10 |
20220040378 | WOUND CARE TREATMENT AND METHODS OF MAKING AND USING SAME - A method of treating a wound including applying a wound care treatment to the wound, the wound care treatment including a preparation composed of morselized amnion tissue and amniotic fluid cells adsorbed to a porous collagen matrix and optionally, glycosaminoglycan. The morselized amnion tissue includes organized amniotic extracellular matrix (ECM), amniotic tissue cells and growth factors contained within the ECM and amniotic tissue cells. The porous collagen matrix is provided as a solid sheet, a meshed or perforated sheet or a flowable material. | 2022-02-10 |
20220040379 | NEW USE OF STEM CELL GENERATOR IN PREPARATION OF BONE DEFECT REPAIR MATERIALS - Disclosed is a new use of a stem cell generator in preparation of bone defect repair materials, wherein the stem cell generator is formed by implanting a biomaterial with osteogenic induction capability or a biomaterial loaded with active substances and/or cells into an animal or a human body and generating organoids after development, the active substances are bone morphogenetic protein-2, or bone morphogenetic protein-7, other growth factors/polypeptides having bone regeneration induction ability, growth factors/polypeptide combinations, or a combination thereof. The cells are bone marrow-derived mesenchymal stem cells, adipose-derived mesenchymal stem cells or other derived mesenchymal stem cells; other types of cells with osteogenic differentiation capability; cells that aid in osteogenic differentiation of mesenchymal stem cells, such as vascular endothelial cells and the like. The stem cell generator is used to prepare bone repair materials for treatment of various types of bone defects or bone deformities that are spontaneous or caused by trauma. | 2022-02-10 |
20220040380 | USE OF STEM CELLS PRODUCED BY STEM CELL GENERATOR IN TREATMENT OF HEMATOPOIETIC DAMAGE - Disclosed is a stem cell generator for the generation of organoids after the development of biological materials loaded with active substances which are implanted into an animal or a human body. The active substances are mesenchymal stem cells, bone morphogenetic protein-2 or bone morphogenesis protein-7, other growth factors/polypeptides or growth factors/polypeptide combinations having the ability of inducing bone regeneration, or combinations thereof. The stem cell generator contains various types of blood cells and hematopoietic progenitor/stem cells having complete functions. The produced stem cells are used for treating hematopoietic damage, and can treat bone marrow failure and leukemia caused by radiotherapy/chemotherapy. | 2022-02-10 |
20220040381 | METHODS AND POLYMER-CONTAINING FORMULATIONS FOR TREATING RETINAL DETACHMENT AND OTHER OCULAR DISORDERS - The invention provides methods and polymer-containing formulations for treating retinal detachment and other ocular disorders, where the methods employ polymer compositions that can form a hydrogel in the eye of a subject. The hydrogel is formed by reaction of (a) a nucleo-functional polymer is a biocompatible polyalkylene polymer substituted by (i) a plurality of —OH groups, (ii) a plurality of thio-functional groups —R | 2022-02-10 |
20220040382 | HYDROGEL CONTAINING POLYMER NANOFIBER HAVING SULFATE GROUP INTRODUCED AND METHOD FOR PREPARING THE SAME - Proposed are a hydrogel containing a polymer nanofiber into which a sulfate group is introduced, and a method for preparing the same. The hydrogel contains polymer compound nanofibers into which a sulfate group is introduced, the polymer compound nanofibers may be connected to each other by a crosslink to form a network structure, and gelling may proceed as water is filled in empty space of the network structure. According to an embodiment, it is possible to provide a hydrogel containing a polymer nanofiber into which a sulfate group is introduced, which is highly utilizable as an artificial extracellular matrix by providing a cell culture scaffold which exhibits high cell adhesiveness and of which the three-dimensional structure can be controlled. | 2022-02-10 |
20220040383 | FILLER HAVING EXCELLENT FILLER PROPERTIES COMPRISING HYALURONIC ACID HYDROGEL - The present invention relates to a filler comprising a hyaluronic acid hydrogel having a lift value in a specific range relative to the unit amount (w/w %) of hyaluronic acid included in a filler, in contrast to the modification degree, and as a result of having said lift value the filler exhibits improved high viscoelasticity flow properties, has the advantages of both monophasic and biphasic hyaluronic acid hydrogel fillers, and thus exhibits good tissue-restoring properties, has low mobility when injected into skin whilst still maintaining the shape thereof for a long time, and has minimized deformation of the hyaluronic acid through the minimization of the use of crosslinkers, and thus the natural form of hyaluronic acid molecules can be maintained, enabling a reduction in the occurrence of immune reactions and side effects, and thus has excellent soft tissue restoration properties, volume expansion properties and wrinkle alleviation properties. | 2022-02-10 |
20220040384 | CENTRAL VENOUS CATHETER, PREPARATION METHOD THEREFOR AND MEDICAL DEVICE COMPRISING SAME - The disclosure relates to a central venous catheter, preparation method thereof and a medical device having the same. The central venous catheter comprises a tube body and a coating formed on the surface of tube body, coating being formed of a coating composition comprising at least one photosensitive functional compound and at least one photocurable polymer. The central venous catheter of the disclosure can prevent thrombosis, dissolve primary thrombus, and possess super-lubricated surface and firm coating bonding. | 2022-02-10 |
20220040385 | LOCAL DELIVERY OF DRUGS FROM SELF ASSEMBLED COATINGS - The invention relates to oligofluorinated coatings and their use in drag delivery. The oligofluorinated coatings are compositions comprising formula (XVII). These coatings are used in a method of delivering a biologically active agent to a tissue surface in a mammalian tissue. This method occurs by contacting the surface with the coating including an oligofluorinated oligomer and a biologically active agent wherein the coating resides on the tissue surface and release the biologically active agent to the tissue surface. | 2022-02-10 |
20220040386 | SEALING AGENT FOR GENITALS - The present invention aims to provide a cervical canal sealant that can be used as a sealant to stop bleeding in the uterus and vaginal discharge, particularly, a cervical canal sealant that can block the cervical canal to inhibit amniotic fluid leakage and that can also be peeled off without damaging reproductive tissue. The present invention relates to a sealant for reproductive organs in which a cured product (X) at 25° C. has a storage modulus G′ of 200 to 2,000 kPa, the cured product (X) being a cured product obtained by curing the sealant for reproductive organs to a thickness of 120 to 150 μm. | 2022-02-10 |
20220040387 | COLLECTION SYSTEM FOR MANAGING OUTFLOW FROM A SURGICAL PROCEDURE - A fluid collection system includes a vacuum source, a collection vessel, and a surgical drape. A fluid outflow line is connected between the surgical drape and the collection vessel. The fluid outflow line provides a path for fluid to the collection vessel. A suction line is connected with the collection vessel. The suction line provides suction to draw fluid through the fluid outflow line to the collection vessel. The suction line branches into a first suction line and a second suction line parallel with the first suction line. The first suction line and the second suction line are each connected with the vacuum source. A flow restrictor is disposed along the first suction line. A valve is disposed along the second suction line. The valve is opened in a pulsatile fashion when fluid is present in the surgical drape to increase a level of suction provided to the surgical drape. | 2022-02-10 |
20220040388 | EXTRACORPOREAL BLOOD TREATMENT DEVICE - The present invention pertains to an extracorporeal blood treatment device ( | 2022-02-10 |
20220040389 | DIALYSIS SYSTEM AND METHODS - Dialysis systems and methods are described which can include a number of features. The dialysis systems described can be to provide dialysis therapy to a patient in the comfort of their own home. The dialysis system can be configured to prepare purified water from a tap water source in real-time that is used for creating a dialysate solution. The dialysis systems described also include features that make it easy for a patient to self-administer therapy. | 2022-02-10 |
20220040390 | DIALYSIS SYSTEMS AND METHODS FOR MODULATING FLOW OF A DIALYSATE DURING DIALYSIS USING RAMAN SPECTROSCOPY - The present invention is a system to continuously monitor, in real-time, the small molecules being dialyzed during hemodialysis treatment using Raman spectroscopy and press control algorithms. By monitoring the treatment, the amount of water needed per dialysis treatment is drastically reduced by optimizing analyte saturation and removal of wastes. This will significantly conserve water and reduce the cost of dialysis treatments, possibly reducing the amount of time necessary for dialysis treatment, improving quality of life for patients during and after treatment, and reducing the costs of building new treatment centers as well as operating costs. | 2022-02-10 |
20220040391 | FLUID FLOW SENSING AND BUBBLE DETECTING APPARATUS AND METHOD FOR IMPROVING A FLUID FLOW SENSING AND BUBBLE DETECTING APPARATUS - A fluid flow sensing and bubble detecting apparatus, comprising:—housing provided with a cavity configured to receive a tube through which conductive fluid flows;—a fluid flow sensing and bubble detecting electrical sensor assembly supported by the housing and configured to sense the flow of the fluid flowing through the tube and to detect bubbles in the fluid; and—an electrically grounded Electro-Magnetic Interference (EMI) shielding arranged between at least a part of the sensor assembly and the cavity such that the EMI shielding protects the sensor assembly from unwanted EMI emanating from a tube received within the cavity, which might otherwise cause the fluid flow sensing and bubble detecting apparatus to generate false bubble detection signals. | 2022-02-10 |
20220040392 | BIOLOGICAL COMPONENT SEPARATION DEVICE - A biological component separation device includes a device main body which is formed of a soft material in a sheet-like shape and in which a filter accommodating unit is provided, a filter member, an introduction port member, and a lead-out port member. An introduction line and a lead-out line are provided in the device main body. In a state in which the device main body is suspended by an introduction tube, a filter accommodating unit inlet where the filter accommodating unit and the introduction line are connected is positioned lower than a filter accommodating unit outlet where the filter accommodating unit and the lead-out line are connected. | 2022-02-10 |
20220040393 | Device and Method for Attenuation of CO2 in Circulating Blood - Systems and methods for the removal of carbon dioxide from circulating blood via the use of microbubbles within a body cavity, optionally including the simultaneous provision of oxygen to the circulatory system. Through placement of microbubbles within a body cavity and the use of a carbon dioxide scavenging catheter, carbon dioxide and/or oxygen exchange may occur. Overall improvement in extending survival rate time during emergency situations caused by pulmonary or similar ventilation restricting injury and/or failure may be achieved. | 2022-02-10 |
20220040394 | SYSTEMS, DEVICES, AND METHODS FOR ASPIRATING BIOLOGICAL MATERIAL FROM A BODY LUMEN - An intraluminal system for aspirating biological material from a lumen of a patient includes a disposable intraluminal device having a proximal portion and a distal portion. The system includes a disposable pump configured to aspirate the biological material from the lumen of the patient. The disposable pump is coupled to the proximal portion of the intraluminal device. The disposable pump comprises a pump chassis that houses: an inlet port configured to sealably attach to the proximal portion of the intraluminal device; an outlet port configured to expel the aspirated biological from the pump; and a flow controller configured to adjust a fluid flow through the pump, wherein the pump chassis is sized and shaped to be manually supported by a user. | 2022-02-10 |
20220040395 | FECAL MANAGEMENT SYSTEMS AND METHODS - Fecal management methods and apparatuses (e.g., devices, systems, etc.) are described herein. The fecal management apparatuses may apply one or more fecal removal cycles of suction and irrigation (and in some examples air) to actively remove fecal material. The apparatus may control the timing of delivery of the fecal removal cycles as well as the parameters of the applied suction, irrigation and/or air within and between fecal removal cycles. | 2022-02-10 |
20220040396 | DEVICE FOR AN ASPIRATOR, ASPIRATOR AND METHOD - A device for an aspirator, the device comprising a suction inlet for suctioned air, liquid and particles; an exhaust outlet for air; a reservoir for collecting liquid and particles separated from the air; and a clearing arrangement fluidly between the suction inlet and the exhaust outlet, the clearing arrangement being configured to provide a path of air, substantially cleared from liquid sucked through the suction inlet, to the exhaust outlet, in any orientation of the device in space. An aspirator comprising a device, and a method of modifying a device for an aspirator, are also provided. | 2022-02-10 |
20220040397 | CLIP - A clip for holding one or more buttons of a medical device in a pre-use state. The clip includes an elongate band for wrapping around the medical device. A receiving portion formed in the elongate band that is configured to receive at least one button when the band is wrapped around the medical device and a retaining means for retaining the band around the medical device. | 2022-02-10 |
20220040398 | DUAL CANNULATED SUCTION AND DELIVERY DEVICE - A medical device related to suction and delivery of components at a surgical site, the device comprising: a shaft body having a suction channel for suctioning a first component from a site, and a delivery channel associated with the shaft body for delivering a second component to the site. | 2022-02-10 |
20220040399 | FAT CUTTER AND INTEGRATED MACHINE FOR PREPARATION OF IN VITRO FINE-PARTICLE FAT - A fat cutter and an integrated machine for preparation of in vitro fine-particle fat are provided. The fat cutter includes a fat inlet channel, a fat outlet channel, at least one set of blades disposed between an outlet of the fat inlet channel and an inlet of the fat outlet channel, and a housing that seals a space in which the outlet of the fat inlet channel, the inlet of the fat outlet channel, and the blades are located. A fat inlet of the fat inlet channel is connected to a large-diameter liposuction tube by a liposuction channel, and a fat outlet of the fat outlet channel is connected to a high-negative pressure device. The outlet of the fat inlet channel and the inlet of the fat outlet channel are oppositely provided, and a gap therebetween matches the thickness of the blades. | 2022-02-10 |
20220040400 | Differential Collapse Wound Dressings - Dressings and kits for use in negative-pressure therapy are provided herein comprising one or more manifolds and a polymer film laminated to the one or more manifolds. At least one manifold is felted and the manifolds may be placed in a stacked configuration and differentially collapse under negative pressure. Methods of making and using the dressings are also provided herein. | 2022-02-10 |
20220040401 | WOUND THERAPY SYSTEMS AND METHODS WITH MULTIPLE POWER SOURCES - The present disclosure provides in part improved apparatuses, systems, and methods for providing therapy to a wound. A system can include a first power source configured to power an electronic component and a second power source configured to power the electronic component in place of the first power source. Responsive to a first condition, the second power source can power the electronic component in place of the first power source. In some cases, the system can include a pressure source that is configured to provide negative pressure to a wound dressing positioned over a wound. The wound dressing can support the first power source or the second power source. | 2022-02-10 |
20220040402 | METHODS AND SYSTEMS FOR AUTOMATIC PULLBACK TRIGGER - One or more devices, systems, methods, and storage mediums for optical imaging medical devices, such as, but not limited to, Optical Coherence Tomography (OCT), single mode OCT, and/or multi-modal OCT apparatuses and systems, and methods and storage mediums for use with same, for triggering auto-pullback, including for devices or systems using blood clearing, are provided herein. Examples of applications include imaging, evaluating and diagnosing biological objects, such as, but not limited to, for Gastro-intestinal, cardio and/or ophthalmic applications, and being obtained via one or more optical instruments, such as, but not limited to, optical probes, catheters, capsules and needles (e.g., a biopsy needle). Techniques provided herein also improve processing and imaging efficiency while achieving images that are more precise. | 2022-02-10 |
20220040403 | INFUSION PUMP CASSETTE LATCH - A tube cassette ( | 2022-02-10 |
20220040404 | MEDICAL DEVICE, EXTERNAL UNIT, POWER TRANSMISSION SHEET, MEDICAL TOOL, AND POSITION DETECTION METHOD - A medical device includes: a power transmitter to transmit power without contact; a power receiver to receive the power that is transmitted from the power transmitter; a medical tool that includes any one of the power transmitter and the power receiver and that is to be embedded in a body and is used; and a notification unit to, when a relative positional relationship between the power transmitter and the power receiver reaches a given state in association with move of any one of the power transmitter and the power receiver, notify that the relative positional relationship enters the given state. | 2022-02-10 |
20220040405 | ANTI-FREE-FLOW VALVE - Apparatus for delivering a fluid to a subject through infusion tubing ( | 2022-02-10 |
20220040406 | METHOD AND APPARATUS FOR THE FAIL-SAFE TERMINATION OF IN VIVO DRUG DELIVERY FROM AN IMPLANTABLE DRUG DELIVERY SYSTEM - A method for the fail-safe termination of in vivo drug delivery from an implantable drug delivery system, the method comprising: providing an implantable drug delivery system comprising: a housing having a reservoir for containing a drug, and a port for dispensing the drug to a patient; and an emergency deactivation unit disposed between the reservoir and the port, the emergency deactivation unit comprising a composite structure comprising a biocompatible ferromagnetic mesh open to fluid flow and a hydrophobic meltable material, the hydrophobic meltable material comprising at least one hole therein for enabling a fluid to pass through the hydrophobic meltable material; implanting the implantable drug delivery system within a patient; enabling the drug to flow from the reservoir, through the at least one hole in the hydrophobic meltable material and out the port; and when drug flow is to be terminated, applying a magnetic field to the composite structure, such that a current is induced in the ferromagnetic mesh which heats the ferromagnetic mesh and melts the hydrophobic meltable material, thereby closing the at least one hole in the hydrophobic meltable material and blocking drug delivery to the patient. | 2022-02-10 |
20220040407 | Method, System, and Computer Readable Medium for Controlling Insulin Delivery Using Retrospective Virtual Basal Rates - Equivalent insulin pump retrospective virtual basal rates for daily injections are constructed from planned insulin injections according to a virtual basal rate profile developed for a patient, and a database of historical insulin injections, i.e. basal injections actually administered by the patient, providing a unified framework for analysis, design, optimization, and adaptation of MDI (multiple daily injections) and CSII (continuous subcutaneous insulin infusion (i.e. insulin pump)) treatment parameters for patients with diabetes. | 2022-02-10 |
20220040408 | INJECTION DEVICE - An injection device comprises a casing, a syringe carrier located within a proximal end of the casing and being movable along a longitudinal axis of the device between a stowed position and a needle insertion position, and a drive assembly located within a distal end of the casing and being movable by an insertion driver in order to move the syringe carrier and a loaded syringe from a stowed position to a needle insertion position. The device further comprises a first formation fixed relative to the casing and a second formation fixed relative to an insertion tube of the drive assembly, the first and second formations defining between them a plurality of stop positions for the insertion tube relative to the casing, spaced along the direction of said longitudinal axis, to prevent significant rearward movement of the insertion tube along said axis when a plunger of a firing cartridge is released from a reaction assembly of the cartridge. | 2022-02-10 |
20220040409 | INJECTION DEVICE, IN PARTICULAR AUTOINJECTOR, FOR THE SIMULTANEOUS ADMINISTRATION OF SEVERAL MEDICATIONS - An injection device is disclosed for the administration of several medications. The injection device includes a carrying housing, an activation sleeve surrounding the carrying housing, at least two carpules, a first drive module for the administration of the medications, a securing device, a needle arrangement, a needle protection element, and a second triggerable drive module for the needle arrangement. The first drive module includes a drive element with a number of piston rods equal to the number of carpules. At least one of the piston rods is configured in the form of a hollow cylinder the is closed on the piston side, wherein arranged inside this is a first drive means of the first drive module. The first drive means can be arranged in an accommodation part of the drive element, wherein the accommodation part forms with the piston rods a composite structural unit. | 2022-02-10 |
20220040410 | NEEDLE-FREE INTRADERMAL INJECTION DEVICE - A needle-free injection device suitable for delivering a therapeutic substance into the intradermal space of a patient. The needle-free injection device includes a first handle positioned to pivot between an open position and a closed position, a main spring, and a hammer engaged with the main spring. The needle-free injection device also includes a return sleeve engaged with the hammer when the first handle is in the open position. The return sleeve is disengaged with the hammer when the first handle is in the closed position. Needle-free injection systems and methods of operating a needle-free injection device are also disclosed. | 2022-02-10 |
20220040411 | SYRINGE - This disclosure describes devices and methods used to inject or aspirate fluid into or from various regions of the human body, such as the anterior chamber of the eye. The disclosed devices and methods provide improvements over conventional devices and methods in that an operator can perform a procedure using the disclosed device without an assistant. The disclosed devices and methods allow one-handed injection or aspiration of fluid into or from body tissue, and provide means for controlling the volume of injected or aspirated fluid. | 2022-02-10 |
20220040412 | SYRINGE AND GASKET SYSTEMS - A process for producing gaskets with an improved channel for use in matched syringe and plunger systems, preferably prefilled plastic syringe systems. In particular, an improved process for making and inspecting continuous channels in a gasket film by laser treatment. The gaskets are useful in matched syringe and plunger systems with high and consistent container closure integrity (CCI), and consistent break loose and glide forces over time, and sealability. | 2022-02-10 |
20220040413 | DEVICES AND METHODS FOR DELIVERY OF SUBSTANCES WITHIN A PREFILLED SYRINGE - An apparatus includes a housing, a carrier, a medicament container, and a flexible member. The housing defines an opening placing a gas chamber of the housing in fluid communication with an exterior volume. The carrier has a proximal surface that defines a portion of the gas chamber. The medicament container is coupled to the carrier and has a distal end portion coupled to a delivery member. The medicament container containing a medicament and includes an elastomeric member that seals the medicament therein. The flexible member has a distal end portion coupled to the elastomeric member and a proximal end portion coupled to a valve member. The flexible member transitions from a collapsed configuration to an expanded configuration when the elastomeric member moves within the medicament container. The flexible member moves the valve member relative to the opening when the flexible member transitions from the collapsed configuration to the expanded configuration. | 2022-02-10 |