06th week of 2017 patent applcation highlights part 34 |
Patent application number | Title | Published |
20170038290 | FLOATING PARTICLE DETECTION DEVICE - A floating particle detection device | 2017-02-09 |
20170038291 | FLOW CYTOMETER - The disclosed flow cytometer includes a wavelength division multiplexer (WDM). The WDM includes an extended light source providing light that forms an object, a collimating optical element that captures light from the extended light source and projects a magnified image of the object as a first light beam, and a first focusing optical element configured to focus the first light beam to a size smaller than the object of the extended light source to a first semiconductor detector. The disclosed flow cytometer further includes a composite microscope objective to direct light emitted by a particle in a flow channel in a viewing zone of the composite microscope to the extended light source, a fluidic system and a peristaltic pump configured to supply liquid sheath and liquid sample to the flow channel, and a laser diode system to illuminate the particle in the flow channel. | 2017-02-09 |
20170038292 | CELL CAPTURE SYSTEM AND METHOD OF USE - A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber. | 2017-02-09 |
20170038293 | METHOD FOR EVALUATING WEATHERABILITY OF FLUORINATED COATING FILM - To provide a method for evaluating the weather resistance by which the weather resistance of a fluorinated coating film can be evaluated accurately in a short time. | 2017-02-09 |
20170038294 | GAS CAP FOR OPTICAL SENSOR - A cap for a gas sensor module is described herein. The cap can include at least one wall forming a cavity having a first portion and a second portion. The cap can also include an inlet tube coupling feature disposed in the at least one wall, where the first location is adjacent to the first portion of the cavity. The cap can further include an outlet tube coupling feature disposed in the at least one wall, where the second location is adjacent to the second portion of the cavity. The cap can also include a distribution channel coupling feature disposed in the at least one wall, where the third location is adjacent to the first portion of the cavity. The cap can further include a receiving channel coupling feature disposed in the at least one wall, where the fourth location is adjacent to the second portion of the cavity. | 2017-02-09 |
20170038295 | COLORIMETRIC SENSOR WITH AUTOMATED READOUT - A system and method to measure properties of a liquid, comprising: a colorimetric sensor comprising a photonic structure that displays a first signature upon exposure to a sample liquid that wets at least some of the interior surfaces of the porous photonic structure and displays a signature different from the first signature as the sample liquid evaporates. The system further includes a device to capture changes in the color of the colorimetric sensor; a memory to store data generated by the device; and a processing unit to analyze the data captured by the device. The processing unit compares the data captured by the device with a reference data, wherein the reference data comprises information regarding a time-dependent response of the colorimetric sensor upon exposure to and removal of a first set of predetermined liquids and to output information regarding the sample liquid. | 2017-02-09 |
20170038296 | DETECTION DEVICE AND PRODUCTION METHOD FOR SAME - A detection device having: a terahertz wave generation element; a terahertz wave detection element; a first transmission path arranged upon the terahertz wave generation element; a second transmission path arranged upon the terahertz wave detection element; and a sealed section arranged between the terahertz wave generation element and the terahertz wave detection element and separated from the first transmission path and the second transmission path, so as to surround the first transmission path and the second transmission path. A space between an emission surface in the first transmission path and an incident surface in the second transmission path is connected to a space between the first transmission path and the sealed section and to a space between the second transmission path and the sealed section. | 2017-02-09 |
20170038297 | APPARATUS AND METHOD FOR CUSTOMIZED HAIR-COLORING - An apparatus and method for customized hair-coloring is disclosed. In some embodiments the method comprises: a. performing a plurality of light-scattering measurements upon a sample of hair such that for each light-scattering measurement, the sample of hair is illuminated from a different respective direction; b. comparing the results of the light-scattering measurements; c. in accordance with results of the comparing, computing an initial damage-state of hair of the sample by comparing the results of the light-scattering measurements; d. obtaining an initial color-state of the hair of the sample; and e. computing a hair-coloring composition that is predicted to transform the hair sample from the initial color-state to a target color-state such that in response to a determining of a greater (lesser) extent of initial damage, a concentration of artificial- colorant(s) within the computed coloring composition is reduced (increased). | 2017-02-09 |
20170038298 | Optical Waveguide, and SPR Sensor Cell and Colorimetric Sensor Cell Which Use Optical Waveguide - An optical waveguide in which the occurrence of a crack in a cladding layer is prevented, and the SPR sensor cell and the colorimetric sensor cell each using the optical waveguide can be provided. The optical waveguide according to the present invention includes a cladding layer and a core layer buried in the cladding layer so that at least one surface of the core layer is exposed. The cladding layer has a surface hardness of HB to 2H. | 2017-02-09 |
20170038299 | ONLINE PROCESS MONITORING - A method to analyze a sample includes performing sample interrogation cycles on the sample to generate replicates. Each of the sample interrogation cycles is performed by: illuminating the sample with two or more fluorescence excitation signals at different wavelengths; and detecting both a fluorescence emission spectral profile and a fluorescence lifetime profile of the sample for each of the two or more fluorescence excitation signals to generate two or more fluorescence emission spectral profiles and two or more fluorescence lifetime profiles of the sample. Each replicate includes the two or more fluorescence emission spectral profiles and the two or more fluorescence lifetime profiles generated for a corresponding one of the sample interrogation cycles. The method includes performing a comparison of the replicates to predetermined spectroscopic relationships. The method includes determining a target analyte concentration of the sample based on the comparison of the replicates to the predetermined spectroscopic relationships. | 2017-02-09 |
20170038300 | STRUCTURED ILLUMINATION MICROSCOPIC DEVICE AND STRUCTURED ILLUMINATION OBSERVATION METHOD - A structured illumination microscopic device includes a first spatial modulation unit spatially modulating a fluorescent sample using an excitation light having a sinusoidal illumination distribution of a spatial frequency K and having an optical frequency ω | 2017-02-09 |
20170038301 | MULTI EXCITATION-MULTI EMISSION FLUOROMETER FOR MULTIPARAMETER WATER QUALITY MONITORING - A fluorometer is provided for monitoring the quality of water, featuring an array of excitation sources, an array of multiple emission detectors and a signal processor. In the array of excitation sources, each excitation source provides respective excitation source optical signaling at a respective illuminating wavelength. The array of multiple emission detectors detects multiple emission wavelengths emitted from water containing information about multiple coexisting fluorescent species present in the water that emit optical radiation at at least two different wavelengths when illuminated by the respective illuminating wavelength provided from the array of excitation sources, and provide multiple emission detector signaling containing information about the multiple coexisting fluorescent species. The signal processor receives the multiple emission detector signaling, and determines corresponding signaling containing information about an identification of the multiple coexisting fluorescent species present in the water using a near-simultaneous identification technique, based upon the multiple emission detector signaling received. | 2017-02-09 |
20170038302 | STABILIZED TEST REAGENT - A 3-methyl-2-benzothiazolinone (MBTH) test reagent having improved stability. | 2017-02-09 |
20170038303 | SELECTIVE COLORIMETRIC DETECTION SENSOR AND SELECTIVE COLORIMETRIC DETECTION METHOD FOR DETECTING HEXAVALENT CHROMIUM IONS USING SIZE CONTROLLED LABEL-FREE GOLD NANOPARTICLES - Disclosed are a selective colorimetric detection sensor and a colorimetric detection method for C | 2017-02-09 |
20170038304 | REAPING BASED YIELD MONITORING SYSTEM AND METHOD FOR THE SAME - A reaping based yield monitor system includes one or more reaping yield instruments configured for coupling with a harvester head. The one or more reaping yield instruments measure at least one crop characteristic of a harvested crop in sections of the harvester head. A yield monitor determines a variable yield of the harvested crop. An apportionment module apportions the variable yield of the harvested crop to the sections of the harvester head based on the at least one crop characteristic measured in each of the sections of the harvester head. In another example, a stand counting module counts a harvested standing crop with the one or more reaping yield instruments and a stand count output module output a harvested standing crop value based on one or more of the counted harvested standing crop or filtered measured values of a stand characteristic measured with the one or more reaping yield instruments. | 2017-02-09 |
20170038305 | IN-SITU SPECTRAL PROCESS MONITORING - Increasing the precision of process monitoring may be improved if the sensors take the form of travelling probes riding along with the flowing materials in the manufacturing process rather than sample only when the process moves passed the sensors fixed location. The probe includes an outer housing hermetically sealed from the flowing materials, and a light source for transmitting light through a window in the housing onto the flowing materials. A spatially variable optical filter (SVF) captures light returning from the flowing materials, and separates the captured light into a spectrum of constituent wavelength signals for transmission to a detector array, which provides a power reading for each constituent wavelength signal. | 2017-02-09 |
20170038306 | SUBSTRATE DAMAGE INSPECTION APPARATUS, PRODUCTION SYSTEM AND INSPECTION METHOD - The present invention relates to the technical field of display, and particularly relates to a substrate damage inspection apparatus, a production system and an inspection method. The substrate damage inspection apparatus comprises a drive unit, support rods, sensors and a controller, wherein the drive unit is connected with the support rods so as to drive the support rods to ascend or descend below a substrate to be detected; and the sensors are disposed on the support rods and communicatively connect with the controller, so as to emit light beams to the substrate to be detected, receive the light beams reflected by the substrate to be detected, and feed them back to the controller. By means of the drive unit and the support rods with the sensors, the substrate damage inspection apparatus realizes damage inspection for the substrate to be detected in a vertical direction. That is, a technical solution provided by the present invention allows for damage inspection for the substrate to be detected when it vertically moves. In addition, the substrate damage inspection apparatus is simple in structure and convenient to operate, thereby having strong utility value and significance of generalization. | 2017-02-09 |
20170038307 | INFORMATION PROCESSING DEVICE, INFORMATION PROCESSING METHOD AND MEDIUM - For detecting a crack formed on a structure surface without erroneously, an information processing device that detects a crack on a structure, includes a change detection unit that detects a change in positions of at least two measurement points on the structure; and a crack detection unit that detects a crack based on the change in the positions of the measurement points detected by the change detection unit. | 2017-02-09 |
20170038308 | APPARATUS AND METHOD FOR INSPECTING CONTAINERS - An apparatus for inspecting containers in a container treatment machine includes an optical probe, for detecting surface irregularities. The probe is formed as an optical coherence tomography probe providing in-plane resolution and/or volume resolution. | 2017-02-09 |
20170038309 | DEVICE AND METHOD FOR DETECTION OF COUNTERFEIT PHARMACEUTICALS AND/OR DRUG PACKAGING - Featured are a device ( | 2017-02-09 |
20170038310 | INSPECTION TOOL - An inspection tool for inspecting oil and/or gas production and/or injection wells and pipes is provided. The tool comprises at least an image sensor, one or more processors or chips and one or more power supplies. The tool further comprises at least a first and a second chamber being insulated from each other. The first chamber comprises the image sensor and is provided with one or more passive cooling means, and the second chamber comprises the one or more processors and is provided with one or more active cooling means. Further, a method for cooling such inspection tool is provided. | 2017-02-09 |
20170038311 | RADIO FREQUENCY MATERIAL ANALYSIS UTILIZING PHASE - Briefly, embodiments of the present invention describe an inexpensive, accurate, rapid and automated method to detecting bubbles, foreign object, debris, dissimilar material or property changes in a liquid, lubricant, compressed gas or fine solid. This method uses the vector signal analysis [also known as a phase-gain meter or automatic network analysis] phase change in the transmitted energy versus the reflected energy in radio waves to detect bubbles, foreign object, debris, dissimilar material or property changes in a liquid, lubricant, compressed gas or fine solid using one, two or three antennas or a coil. This method describes the means by which to develop the specific sensor for the intended application. This method also describes the method by which to develop and tune a specific sensor for an exact application. This method also describes the type of sensor that would be used with the described method of detection. This method also describes the application of a sensor employing this method that includes: medical devices, printer ink, manufacturing/refining processes, industrial food processing, engine fuel monitoring, specific property sensing and lubricant property sensing. | 2017-02-09 |
20170038312 | RADIOPAQUE PROTECTIVE FILL FOR MANUFACTURE, REPAIR, OR REMANUFACTURE OF COOLED COMPONENTS - A method of manufacturing a core for casting a component can include manufacturing a core for at least partially forming an internal passage architecture of a component with a material including radiopaque particles. A method can include removing a material including radio opaque particles from an internal passage architecture of a component; and inspecting the component via radiographic imaging at gamma/X-ray wavelengths to detect residual material. A core for use in casting an internal passage architecture of a component can include a material with radiopaque particles dispersed therein. | 2017-02-09 |
20170038313 | Methods and System for Determining Shear Angle - A method for determining an actual shear angle between an interior wall and a facesheet of a cellular panel using an imaging system is disclosed. The imaging system may include a radiation source and a detector diametrically opposed to the radiation source. The method may include positioning the cellular panel at a tilt angle relative to a line extending between the radiation source and the detector, transmitting radiation from the radiation source to the detector through the cellular panel at the tilt angle to obtain an image, measuring a projected shear angle in the obtained image, and determining the actual shear angle between the interior wall and the facesheet using the tilt angle and the projected shear angle. | 2017-02-09 |
20170038314 | IMAGE ACQUISITION DEVICE AND IMAGE ACQUISITION METHOD - An image acquisition device is an image acquisition device that acquires an X-ray transmission image of an object conveyed in a conveyance direction, and the image acquisition device includes an X-ray irradiator that outputs an X-ray, a belt conveyor that conveys the object in the conveyance direction, an X-ray detection camera having a scintillator that converts an X-ray penetrating the object into scintillation light, a line scan camera that detects the scintillation light and outputs a detection signal, and an amplifier that amplifies the detection signal at a predetermined set amplification factor and outputs a amplified signal, a controller that generates an X-ray transmission image based on the amplified signal, and an amplifier controller that sets one of a first amplification factor or a second amplification factor corresponding to an amplification factor lower than the first amplification factor as the set amplification factor based on a predetermined imaging condition. | 2017-02-09 |
20170038315 | OPERATION GUIDE SYSTEM FOR X-RAY ANALYSIS, OPERATION GUIDE METHOD THEREFOR, AND OPERATION GUIDE PROGRAM THEREFOR - Provided is an operation guide system for an X-ray analysis, including: a sample information acquisition portion for acquiring sample information on a sample to be measured for a predetermined analysis purpose with an X-ray measuring unit; a measurement condition acquisition portion for acquiring a plurality of measurement conditions different from one another; a virtual result acquisition portion for subjecting the sample information to simulations respectively based on the plurality of measurement conditions, to thereby acquire a plurality of virtual measurement results of measurements for the predetermined analysis purpose; and a comparison result output portion for outputting, as comparison results, at least two virtual measurement results among the plurality of virtual measurement results and at least two of the plurality of measurement conditions respectively corresponding to the at least two virtual measurement results. | 2017-02-09 |
20170038316 | SYSTEM AND METHOD FOR INTERNAL INSPECTION OF RAIL COMPONENTS - An internal imaging system has a radiation source and a plurality of detectors positioned to receive portions of the plurality of collimated beams that have been attenuated by interaction with the target. The radiation source is configured to irradiate a target with a plurality of collimated beams of radiation. Two of the plurality of collimated beams of radiation may have different beam shapes. Another internal imaging system includes a radiation source configured to irradiate a target with at least one collimated beam of radiation and at least one detector. A planar rotating collimator is positioned adjacent to the radiation source and is configured to form the at least one collimated beam. The at least one detector is positioned to receive attenuated portions of the at least one collimated beam. The radiation source may be or include a neutron source. The detectors may be or include a plurality of neutron converters. | 2017-02-09 |
20170038317 | X-RAY MULTIGRAIN CRYSTALLOGRAPHY - Disclosed is method of determining one or more unit cells of a poly-crystalline sample and indexing a set DV of 3D diffraction vectors . The method comprising obtaining a plurality of candidate first lattice plane normal vectors and a plurality of candidate second lattice plane normal vectors for a particular unknown grain; using said plurality of candidate first lattice plane normal vectors and said plurality of candidate second lattice plane normal vectors to select a plurality of subsets SSDV_n of the set DV of 3D diffraction vectors and processing said plurality of subsets SSDV_n of 3D diffraction vectors to determine a primary candidate unit cell PCUC defined by three lattice vectors; wherein the primary candidate unit cell PCUC is validated by evaluating the fit of the PCUC with the full set DV of 3D diffraction vectors. | 2017-02-09 |
20170038318 | X-RAY TALBOT INTERFEROMETER - An X-ray Talbot interferometer includes a source grating having a plurality of X-ray transmitting portions to transmit some X-rays from an X-ray source, a beam splitter grating configured to diffract the X-rays from the X-ray transmitting portions with a periodic structure to form interference patterns, an analyzer grating configured to block parts of the interference patterns, and a detector configured to detect X-rays from the analyzer grating. The X-ray transmitting portions of the source grating are arranged to form a periodic pattern in which spatial frequency components contained in a sideband resulting from modulation caused by the presence of an object are enhanced by superimposing the interference patterns corresponding to the respective X-ray transmitting portions. In the absence of any object, the positional relation between the periodic pattern and the grating pattern of the analyzer grating is substantially the same over the entire imaging field. | 2017-02-09 |
20170038319 | METAL ANALYSIS DURING PHARMACEUTICAL MANUFACTURING - A system and method for detecting, measuring, and analyzing for metallic impurities in pharmaceutical drugs and compounds utilizes an x-ray fluorescence system. The system and method may be co-located with a pharmaceutical manufacturing process for in-line continuous monitoring of metal impurities. The pharmaceutical products may be in a form selected from a powder, slurry, pill, tablet, and gel. | 2017-02-09 |
20170038320 | MONITOR FOR MEASURING MERCURY EMISSIONS - A mercury emissions monitor includes a mercury sensor tape configured to be fed in a reel-to-reel manner between first and second tape reels, wherein the mercury sensor tape includes a thin metallic film configured to form an amalgam with detected mercury. A mercury collection unit is configured to receive into a chamber a sample of a gas containing mercury, wherein the mercury collection unit is further configured to permit passage of portions of the mercury sensor tape through the chamber containing the gas sample so that the amalgam is formed with the thin metallic film. A mercury analysis unit includes a total reflection x-ray fluorescence (“TXRF”) system configured to perform a TXRF analysis of the amalgam, wherein the mercury analysis unit is configured to permit passage of the mercury sensor tape within a proximity of an XRF detector of the TXRF system. The mercury collection unit and the mercury analysis unit are positioned between the first and second tape reels so that the mercury sensor tape can move in a continuous manner from the first tape reel through the chamber of the mercury collection unit, then within sufficient proximity to the XRF detector, to be then taken up onto the second tape reel. | 2017-02-09 |
20170038321 | ANALYZING AN OBJECT USING A PARTICLE BEAM APPARATUS - Described herein is a method for analyzing an object using a particle beam apparatus, for example an electron beam apparatus and/or an ion beam apparatus, or using an x-ray beam device and a particle beam apparatus or an x-ray beam device, by means of which the method is carried out. In the method, information about the object is loaded from a data memory into a control device. Furthermore, a group of detection units from the multiplicity of detection units is identified using the information loaded into the control device. A first detector segment is formed from the group of detection units using the control device. Interaction particles and/or interaction radiation, which is/are detected, is/are generated by guiding a particle beam onto the object and scanning the object using the particle beam, where a detector segment signal is read from the detector segment. | 2017-02-09 |
20170038322 | FABRIC WITH DEGRADABLE SENSOR - A fabric comprising at least one conductive element to define at least one portion of an electric circuit, and a sensor coupled to said conductive element, wherein the sensor comprises a degradable element configured to at least partially degrade in preset conditions to change an electric feature of said sensor. An article comprising the fabric and a process for monitoring the life-cycle of the fabric are also disclosed. | 2017-02-09 |
20170038323 | WIRELESS SENSOR AND METHOD OF INTERROGATING THEREOF - A wireless sensor array communication system includes a plurality of wireless sensors each including a resonant circuit that is excited by an RF pulse so as to provide a resonant energy proportional to a measurand being monitored. A transceiver of an interrogator system transmits RF pulses to each of the sensors to excite the resonant circuits therein and receives RF signals transmitted from each of the sensors that are indicative of the resonant energy provided by the resonant circuit. A magnet-gradient coil arrangement of the interrogator system generates a magnetic field and selectively applies magnetic field gradients along a number of axes, such that a frequency and phase of the resonant energy provided by the resonant circuit of each wireless sensor is altered responsive thereto, with the altered frequency and phase of the resonant energy being a function of a location of the respective wireless sensor within the magnetic field. | 2017-02-09 |
20170038324 | PERMEABILITY EVALUATION METHOD - A permeability evaluation method for evaluating permeability of heavy metal ions through a specimen, comprising a step of, in a state in which a first liquid containing heavy metal ions and a second liquid containing water and an organic solvent are separated by a specimen, applying a voltage between a positive electrode provided on the side of the first liquid and a negative electrode provided on the side of the second liquid and measuring the value of the current flowing between the positive electrode and the negative electrode, wherein the specimen contains an insulating material used in semiconductor production, and the heavy metal ion concentration of the first liquid is 0.5 mg/kg or more. | 2017-02-09 |
20170038325 | Humidity Sensor, Wireless Device Including the Same, and Methods of Making and Using the Same - A tag or smart label including a humidity sensor, and methods of manufacturing and using the same, are disclosed. The tag or smart label includes a substrate or backplane with a battery or antenna, a humidity sensor, and an integrated circuit thereon. The integrated circuit is in electrical communication with the humidity sensor and the antenna or battery, and is configured to process a signal from the humidity sensor corresponding to the humidity level or value in the environment to be monitored, and provide or generate a signal that represents the humidity level/value. The humidity sensor includes first and second electrodes that are a predetermined distance apart, a humidity-sensitive material having one or more electrical, mechanical or chemical properties that vary as a function of the humidity level/value, and a water- and/or humidity-permeable membrane covering the humidity-sensitive material. | 2017-02-09 |
20170038326 | Highly Selective Nanostructure Sensors and Methods of Detecting Target Analytes - A nanostructure sensing device comprises a semiconductor nanostructure having an outer surface, and at least one of metal or metal-oxide nanoparticle clusters functionalizing the outer surface of the nanostructure and forming a photoconductive nanostructure/nanocluster hybrid sensor enabling light-assisted sensing of a target analyte. | 2017-02-09 |
20170038327 | Systems And Methods For Humidity Measurement Using Dielectric Material-Based Relative Humidity Sensors - Systems and methods are provided that may be implemented to improve accuracy of relative humidity (RH) determination from dielectric sensing material-based RH sensors, e.g., by decreasing shift and drift effects and compensating for dielectric material aging to improve RH sensor accuracy. The disclosed systems and methods may be implemented to improve RH sensing accuracy by correcting humidity-sensitive electrical parameters (e.g., capacitance, effective resistance, etc.) based on other other measured sensor electrical operating characteristics (e.g., such as real time sensor circuit phase angle) and/or selection of sensor electrical parameters (e.g., such as optimized operating frequency) that are employed for sensing changes in dielectric constant of a dielectric material-based RH sensor. | 2017-02-09 |
20170038328 | ACTIVE CONTROL GUARDS AND RATIONOMETRIC CALIBRATION AND RECONSTRUCTION FOR USE WITH ELECTRICAL CAPACITANCE VOLUME TOMOGRAPHY - A method and system for generating a three-dimensional tomograph of a vessel interior or other object using a sensor having a plurality of electrodes and active control segments that are electrically isolated from the electrodes. | 2017-02-09 |
20170038329 | High-Pressure Reference Electrode for Application in Systems Containing High-Pressure Gases - When a pressure-balanced reference electrode is exposed to a system containing a high-pressure gas (such as CO | 2017-02-09 |
20170038330 | METHOD FOR ESTIMATING DISTRIBUTION OF SAMPLE - The present invention relates to a method for estimating a distribution of a sample flowed from a first electrode toward a second electrode of an electrochemical test strip. A working voltage is provided between the first electrode and the second electrode for obtaining a first and a second currents, where a ratio of the first current to the second current is applied to estimate the distribution of the sample on the first and the second electrodes and an effectiveness of a measurement of a target analyte of the sample. | 2017-02-09 |
20170038331 | SYSTEM AND METHOD FOR COMPENSATING SAMPLE-RELATED MEASUREMENTS BASED ON POLARIZATION EFFECTS OF TEST STRIPS - A system and a method for correcting an analyte concentration measurement taken by a test strip is described herein. The test strip includes at least two spaced apart electrodes defining an electrochemical cell or reaction chamber. An initial polarization parameter of the test strip is determined at the time of test strip manufacture and a testing polarization parameter is determined at the time of testing. A resulting correction factor is then determined based on the initial and testing polarization parameters. The correction parameter can be applied to a measured analyte concentration in order to correct the measured analyte concentration. | 2017-02-09 |
20170038332 | Apparatus, Method and System for Detecting Salt in a Hydrocarbon Fluid - A method for determining a salt concentration of a hydrocarbon fluid using a conductivity sensor and a hydrocarbon testing solution includes forming the hydrocarbon testing solution. The electropolymerizable monomer is operable to form a resultant associated polymer at a peak potential of the electropolymerizable polymer. The method includes introducing the hydrocarbon testing solution into the conductivity sensor. The method includes inducing a range of potential across the hydrocarbon testing solution such that at least a portion of the electropolymerizable monomer polymerizes. The range of induced potential includes the peak potential of the electropolymerizable polymer. The method includes detecting a range of electrical current associated with the range of potential induced. The method also includes the step of determining the salt concentration of the hydrocarbon fluid using the range of potential induced and the range of electrical current detected. | 2017-02-09 |
20170038333 | SYSTEMS AND METHODS FOR SELECTIVELY ADDRESSING SPARSELY ARRANGED ELECTRONIC MEASUREMENT DEVICES - A circuit comprising a substrate with sectors on the substrate is provided, each sector comprising clock and data lines, a controller in electrical communication with the clock and data lines, a counter bias line, an amplifier input line and nano-electronic measurement devices on the substrate. A source of each device is coupled to the counter bias line and a drain of each device is coupled to the amplifier input line to obtain an electrical signal on the drain, the identity of which is determined by electrical interaction between the device and a charge label. Each device drain is gated by a corresponding switch between an on state, in which the drain is connected to the amplifier input line, and an off state, in which the drain is isolated from the amplifier input line. The controller controls switch states responsive to clock signal line pulses and data input line data. | 2017-02-09 |
20170038334 | ELECTRIC FIELD DIRECTED LOADING OF MICROWELL ARRAY - An apparatus includes a device substrate including an array of sensors. Each sensor of the array of sensors can include a electrode structure disposed at a surface of the device substrate. The apparatus further includes a wall structure overlying the surface of the device substrate and defining an array of wells at least partially corresponding with the array of sensors. The well structure including an electrode layer and an insulative layer. | 2017-02-09 |
20170038335 | FRAME MEMBER-EQUIPPED TRANSFER FILM, BIOMOLECULE ANALYSIS DEVICE, REAGENT TANK, AND SHAKING DEVICE - A frame member-equipped transfer film ( | 2017-02-09 |
20170038336 | BIOMOLECULE ANALYZER - A biomolecule analyzer ( | 2017-02-09 |
20170038337 | SAMPLE SEPARATION/TRANSFER DEVICE AND SAMPLE ANALYSIS METHOD - A novel technique is provided for automatically performing the separation and transfer of analyte, and subsequent processing. A sample separation/transfer device ( | 2017-02-09 |
20170038338 | WIRE ROPE INSPECTION APPARATUS - Provided is a wire rope inspection apparatus that is light, small in size and portable. A portable rope tester has a sensor device for sensing magnetic leakage flux leaking from a magnetized wire rope. Provided on the front of sensor device is a sensor face formed to be flat. The sensor face is pressed against the wire rope. By pressing the flat sensor face against the wire rope, magnetic leakage flux is sensed by the sensor device and whether the wire rope is damaged or not is detected. A handle is secured to the back of the sensor device on the side opposite the sensor face. The sensor device is held by grasping the handle by hand, and the sensor face of the device is pressed against the wire rope. | 2017-02-09 |
20170038339 | MUD SETTLEMENT DETECTION TECHNIQUE BY NON-DESTRUCTIVE ULTRASONIC MEASUREMENTS - Systems and methods of determining settlement characteristics of a drilling mud are disclosed. Conditions under which heavier elements of the drilling mud settle under the influence of gravity can be determined. Samples of drilling mud can be placed in testing cells, and ultrasonic test pulses can be transmitted through the samples. Responses to the test pulses can be detected and compared to other responses detected at different vertical positions within the testing cell. Settlement can be detected when the responses from different vertical positions are generally dissimilar. An environmental temperature of the testing cell can be changed over a testing time interval, and a settlement temperature can be determined by detecting a divergence in the responses from different vertical positions. | 2017-02-09 |
20170038340 | DEVICE FOR INSPECTING A STRUCTURE - There is presented a device for being secured to a structure. The device comprising a first portion comprising an element configured to impart mechanical waves to the structure upon application of a voltage and a second portion supporting the element and comprising a body. The body may be elastomeric, flexible, or both. The first and second portions are configured such that the element reacts against the second portion to generate mechanical waves at least partially within the structure. The body attenuates mechanical waves propagating from the first portion and away from the structure. A securing device for securing a mechanical wave generator to a structure and a system comprising the securing device are also presented. | 2017-02-09 |
20170038341 | SPECIALLY DESIGNED PHASED ARRAY TRANSDUCER FOR THE INSPECTION OF FASTENER HOLES AND ADJACENT STRUCTURE WITHOUT THE REMOVAL OF THE FASTENER - A phased array transducer for inspecting a fastener hole and adjacent structure to identify defects and determine hole integrity without removing the fastener from the hole. The phased array transducer includes a plurality of transducer elements, where one of the transducer elements is used to align the transducer to the hole, one group of the remaining transducer elements inspects the entire thickness of the structure at one side of the fastener and another group of the remaining transducer elements inspects the entire thickness of the structure at an opposite side of the fastener. | 2017-02-09 |
20170038342 | SYSTEMS FOR QUALITY MONITORING OF ADDITIVE MANUFACTURING - A system for quality monitoring of additive manufacturing includes an acoustic emission (AE) sensor configured to be attached to an additive manufacturing substrate and to output a sensor signal indicative of acoustic vibrations received at the AE sensor and an AE module. The AE module is configured to receive the sensor signal from the AE sensor and process the sensor signal to determine at least one characteristic of an additive manufacturing process and/or an additively manufactured article. | 2017-02-09 |
20170038343 | BOX-IN-BOX GAS SENSOR HOUSING - A housing for a gas sensor module is described herein. The housing can include an outer portion and an inner portion disposed within the outer portion. The outer portion can include at least one wall forming a first cavity. The outer portion can also include an inlet tube coupling feature disposed at a first location in the at least one first wall, and an outlet tube coupling feature disposed in a second location in the at least one first wall. The inner portion can include at least one second wall forming a second cavity, and a distribution channel coupling feature disposed at a third location in the at least one second wall. The inner portion can also include a receiving channel coupling feature disposed in a fourth location and a tuning fork coupling feature disposed at a fifth location in the at least one second wall. | 2017-02-09 |
20170038344 | IMPROVEMENTS IN OR RELATING TO SONAR APPARATUS - A method of determining at least part of the structure of an object the method comprising the steps of providing at least one wideband acoustic signal transmission and reception device, the at least one wideband acoustic signal transmission and reception device being capable of transmitting and receiving one or more wideband acoustic signals, using the at least one wideband acoustic signal transmission and reception device to transmit at least one wideband acoustic signal towards at least a portion of the object, using the at least one wideband acoustic signal transmission and reception device to receive at least one wideband acoustic signal from the object, using the received at least one wideband acoustic signal from the object to createat least one acoustic data set, and analysing the at least one acoustic data set to determine the at least part of the structure of the object. | 2017-02-09 |
20170038345 | PASSIVE COLUMN PRE-HEATER FOR USE IN CHROMATOGRAPHIC SYSTEMS - A passive pre-heater assembly includes a thermally conductive heat-spreading block and a plurality of passive pre-heaters in thermally conductive communication with the heat-spreading block. The plurality of the pre-heaters exchanges heat with the thermally conductive heat-spreading block. Each pre-heater includes a thermally conductive base in thermal communication with the heat-spreading block, and a plurality of thermally conductive fins is in thermal communication with the thermally conductive base. The plurality of fins of each pre-heater exchanges heat convectively with ambient air and conductively with the thermally conductive base of that pre-heater. A given one of the passive pre-heaters further comprises a tube in thermally conductive contact with the thermally conductive base of the given passive pre-heater. The thermally conductive heat-spreading block exchanges heat with a fluid passing through the tube of the given passive pre-heater. | 2017-02-09 |
20170038346 | CONVECTIVELY CONTROLLED ADIABATIC COLUMN CHAMBER FOR USE IN CHROMATOGRAPHIC SYSTEMS - A column-conditioning enclosure includes a column chamber adapted to hold one or more chromatography separation columns. A duct system provides an airflow path around the column chamber such that the one or more chromatography separation columns held within the column chamber are isolated from the airflow path. An air mover disposed in the airflow path generates a flow of air within the duct system. A heat exchanger system disposed in the airflow path near the air to exchange heat with the air as the air flows past the heat exchanger system. The air circulates through the duct system around the column chamber, convectively exchanging heat with the column chamber to produce a thermally conditioned environment for the one or more chromatography separation columns held within the column chamber. | 2017-02-09 |
20170038347 | CHROMATOGRAPHY SYSTEMS WITH MOBILE PHASE GENERATORS - Certain configurations of a gas chromatography system comprising an internal gas generator are described. In some instances, the gas chromatography system may comprise an internal hydrogen generator to provide hydrogen gas to a chromatography column for separation of analyte species. In certain examples, the gas chromatography system can be operated without any external gas inputs. | 2017-02-09 |
20170038348 | Gas Chromatograph Column Connection Device - A column connection device for use in gas chromatography is disclosed. The column connection device includes a housing with a piston, a piston spring retainer, and disk springs composed of an austenite nickel-chromium-based superalloy (e.g. Special Metals Corp.'s Inconel family of metals). The piston has a ferrule on its exposed end. The disk springs urge the ferrule against the mating portion of an external device maintaining a seal with the external device and creating a seal radially around a column disposed within. The column connection device also includes a release slider and a column base with a column retainer, column tab, and wire springs composed of an austenite nickel-chromium-based superalloy. The wire springs urge the column tab to frictionally engage the column, thereby inhibiting column movement. Depressing the release slider flexes the wire springs, urging the column tab away from the column, removing the frictional inhibition. | 2017-02-09 |
20170038349 | PLATE FOR GAS CHROMATOGRAPH WITH A CAPILLARY COLUMN, CAPILLARY DEVICE AND GAS CHROMATOGRAPH - The present invention relates to gas chromatography with capillary column and more particularly to a plate for gas chromatograph with a capillary column, a capillary device and a gas chromatograph comprising such capillary device. At least one face of the plate is etched with a furrow forming a first part of the capillary column. The capillary device 4 comprises at least two planes closely stacked with each other to form the capillary column of the gas chromatograph. The capillary device thus provided has advantageously reduced dimensions with respect to a laboratory gas chromatograph and a capillary column with conventional dimensions with respect to a laboratory gas chromatograph. | 2017-02-09 |
20170038350 | CHROMATOGRAPHY APPARATUS HAVING DIFFUSION-BONDED AND SURFACE-MODIFIED COMPONENTS - A microfluidic device for separating a sample by chromatography includes diffusion bonded metallic sheets joined together to create a hermetically sealed interface between each adjacent metallic sheet without the introduction of a secondary material. Enclosed within the diffusion bonded sheets is a separation channel accessible by at least one of an inlet or an outlet. The separation channel is packed with micrometer-sized particles serving as a stationary phase in a chromatographic separation. Wetted surfaces of the separation channel include a coating of an organic material at least one monolayer thick. | 2017-02-09 |
20170038351 | Multi-Trace Quantitation - Systems and methods are provided for calculating the area of a peak profile using information from one or more correlated peak profiles. One or more compounds are separated from a mixture over time using a separation device. Traces of the one or more compounds are monitored during the separation using a tandem mass spectrometer. A plurality of intensity measurements are received using a processor. A first peak profile for a compound of interest is detected from the plurality of intensity measurements for a first trace and one or more correlated peak profiles for the compound of interest are detected from the plurality of intensity measurements for one or more other traces using the processor. An area of the first peak profile is calculated based on the one or more correlated peak profiles using the processor. | 2017-02-09 |
20170038352 | PROCESS FOR TRANSFER OF A METHOD FROM A STARTING SYSTEM TO A TARGET SYSTEM IN LIQUID CHROMATOGRAPHY - A process for transferring a method from a starting system to a target system in liquid chromatography, in particular in high performance liquid chromatography, is described. A first chromatogram of the method carried out on the starting system is available or determined. The method developed for the starting system is carried out on the target system without any change in its physical parameters, and a second chromatogram is thereby determined. The two chromatograms of the starting system and the target system are compared, and measures for adjusting the physical system parameters of the target system are derived from the deviations. | 2017-02-09 |
20170038353 | Pathogen Surrogates Based on Encapsulated Tagged DNA for Verification of Sanitation and Wash Water Systems for Fresh Produce - A pathogen surrogate, formed by a DNA tag or bar code and a carrier, is described for use in the validation and verification of sanitation, such as in food processing operations and for wash water systems for fresh produce. The carrier material is selected so that the pathogen surrogate mimics the behavior of a pathogen when subjected to a sanitation operation. One or more surrogates can be introduced in to an environment, which is then subjected to sanitation process, followed by a detection process using the DNA tag of the surrogate. | 2017-02-09 |
20170038354 | TEMPERATURE COMPENSATION OF GAS SENSORS - A target gas sensor employing a radiation source ( | 2017-02-09 |
20170038355 | GAS DETECTING DEVICE AND GAS DETECTING METHOD USING THE SAME - A gas detecting device and a gas detecting method using the same are provided. The gas detecting device includes a casing, a gas detecting element, a first value, a second value and a forced exhausting element. The casing has a cavity, an inlet and an outlet. The gas detector is disposed within the cavity. The first value is for selectively opening or closing the inlet. The second value is for selectively opening or closing the outlet. The forced exhausting element is disposed within the outlet. | 2017-02-09 |
20170038356 | Method and apparatus for assessing the current state of doneness of a cooking food item - A method and apparatus is provided for assessing the current state of doneness of a cooking food item. In a preferred embodiment, a sharpened hollow tubular cutting member of relatively small diameter is rotationally activated to cut and remove from a cooking food item a cylindrical core sample, preferably throughout its entire thickness, without substantial distortion of the shape of the sample. Upon expulsion from the cutting member, inspection of the core sample permits visual determination of the current state of doneness of the food item. | 2017-02-09 |
20170038357 | APPARATUS, SYSTEM, AND METHOD FOR WATER CONTAMINANT TESTING - A system for detecting and quantifying an analyte in a liquid includes a vial including one or more pre-dosed reagents disposed in the vial. The vial is configured to hold a volume of a liquid including an analyte. The one or more pre-dosed reagents are dissolvable in the volume of the liquid to form a sample liquid solution comprising chromophores or fluorophores. The analyte and the one or more pre-dosed reagents react to yield the chromophores or fluorophores. The system further includes a detection device including a chamber configured to retain the vial, the detection device configured to quantify the analyte in the sample liquid solution. | 2017-02-09 |
20170038358 | CONCENTRATION-FACTOR MEASUREMENT DEVICE, CONCENTRATION-FACTOR MEASUREMENT METHOD, AND WATER-QUALITY-INDEX-VALUE MEASUREMENT METHOD - Provided are a concentration-factor measurement device and method for accurately calculating a concentration factor of circulating water, and a method for measuring a water-quality index value of the circulating water. The concentration-factor measurement device includes a light-absorbance measurement unit ( | 2017-02-09 |
20170038359 | PRODUCTS AND PROCESSES FOR ANALYZING OCTANE CONTENT - Products and processes are provided herewith for analyzing octane content in a fuel sample that include the step or steps of receiving an octane measurement of a fuel sample from a octane analyzer, rounding the octane measurement to a nearest recognized octane rating, comparing the rounded octane measurement with a listed octane rating for the fuel sample, and communicating results of the comparison to a user of the octane analyzer. The octane analyzer may be incorporated into a fuel pump or a vehicle. The results of the comparison may also be used to adjust the vehicle operating parameters to account for the actual octane rating of the fuel dispensed into the vehicle. | 2017-02-09 |
20170038360 | MANAGING FUEL OIL MIXTURE IN ENGINES - A fuel tank containing a fuel and oil mixture is managed to determine if the fuel and oil mixture contains the correct ratio for a motor. The fuel tank containing a fuel and oil mixture is monitored. A fuel to oil ratio is selected for the motor. A combined viscosity of the fuel and oil mixture is calculated with respect to the fuel to oil ratio, and the temperature of the fuel and oil mixture. The combined viscosity is used to determine a predetermined range of the combined viscosity. The viscosity of the fuel and oil mixture within the fuel tank is measured as a measured viscosity. If the measured viscosity of the fuel and oil mixture does not correspond with the predetermined range, then a user may be alerted that the measured viscosity does not correspond with the predetermined range. | 2017-02-09 |
20170038361 | MULTIWELL MICROELECTRODE ARRAY WITH OPTICAL STIMULATION - An electro-optical stimulation and recording system is disclosed, including a substrate and a plurality of wells coupled to the substrate. The system also includes at least one electrode set disposed proximate a respective one of the plurality of wells, wherein the electrode set comprises at least one electrode configured to collect an electric signal associated with at least a portion of the respective well. The system also includes a light-emitting element set corresponding to a respective one of the wells and configured to deliver optical stimulation to at least a portion of the respective well. | 2017-02-09 |
20170038362 | Combination of Single-Cell Electroporation and Electrical Recording Using the Same Electrode - Methods for stimulating exocytosis from a cell are provided where the same electrochemical microelectrode is used to electroporate an adjacent cell and then measure quantal exocytosis from the adjacent cell. Also provided are methods for stimulating and measuring exocytosis from a select cell population arrayed on a chip comprising addressable electrodes. Calcium independent stimulation of exocytosis with inorganic anions such as chloride ions is also provided. These methods can provide for specific stimulation of a desired subset of cells without exposing other nearby cells to the stimulus. | 2017-02-09 |
20170038363 | TEST STRIP EJECTOR FOR MEDICAL DEVICE - A system for receiving and ejecting a fluid testing device test strip includes a strip connector having first and second guide rails, and divider walls each having a channel. A sled has first and second legs connected to a cross member. Each leg has a contact leg extending inwardly from a chamfered end. The first and second legs when positioned parallel to the guide rails have the contact leg captured in the divider wall channels retaining the sled in sliding contact with the guide rails for motions in loading and ejection directions. A mechanism assembly is movably connected to the fluid testing device. The cross member is coupled so operation in a first direction displaces the sled in the loading direction positioning the sled in a test strip test position, and opposite operation positions the contact legs in direct contact with and ejects the test strip. | 2017-02-09 |
20170038364 | Systems And Methods Enabling Patch-Clamp Re-Use - A method for cleaning patch-clamp glass pipette electrodes that enables their re-use. By immersing pipette tips or planar patch clamp chips into a detergent, followed by rinsing, pipettes and planar patch clamp chips were re-usable at least ten times with little to no degradation in signal fidelity, in experimental preparations ranging from human embryonic kidney cells to neurons in culture, slices, and in vivo. | 2017-02-09 |
20170038365 | SMALL MOLECULE INHIBITORS OF 8-OXOGUANINE DNA GLYCOSYLASE-1 (OGG1) - Disclosed herein are methods of identifying small molecule compounds that are likely to be OGG1 inhibitors, kits that facilitate the performance of the methods, and methods of inhibiting OGG1 in vitro and in vivo. | 2017-02-09 |
20170038366 | SIGNAL AMPLIFICATION IN SOLUTION-BASED PLASMONIC SPECIFIC-BINDING PARTNER ASSAYS - The present invention relates to analyte detection devices and methods of using such devices to detect minute quantities of a target analyte in a sample. In particular, the invention provides a method of detecting a target analyte in a sample comprising mixing the sample with a first detection conjugate and a second detection conjugate in solution, wherein the first and second detection conjugates comprise metallic nanostructures coupled to binding partners that are capable of specifically binding to the target analyte if present in the sample to form a complex between the first detection conjugate, the analyte, and the second detection conjugate, wherein a change in an optical signal upon complex formation indicates the presence of the target analyte in the sample. Methods of preparing nanostructures and nanoalloys, as well as nanostructures and nanoalloys conjugated to binding partners, are also described. | 2017-02-09 |
20170038367 | SYSTEMS AND METHODS FOR THE MONITORING OF PROTEIN COMPLEX FORMATION IN CELLS - Described herein is a bioluminescence resonance energy transfer (BRET) based system and method to monitor ternary complex formation in real-time in live cells with high sensitivity and accuracy. This system transfers energy simultaneously between a luciferase donor and intermediate and terminal acceptors, appropriately chosen to also enable transfer from the intermediate to terminal acceptor while minimizing contaminating signals. The system may also be adapted for quaternary complex detection by including a protein complementation assay (PCA) component. The system is broadly applicable to the detection of any protein ternary/quaternary complex such as those involving nuclear receptors, GPCRs, Receptor Tyrosine Kinase (RTKs), multimeric enzymes or structural proteins. | 2017-02-09 |
20170038368 | DIGITAL MICROFLUIDICS SYSTEM AND METHOD - A system and method for sample droplet processing, the system including a substrate, an electrode array network coupled to the substrate and configured to provide a pattern of controlled electric fields for manipulation of the set of sample droplets; a first layer in communication with the electrode array network, the first layer separating the electrode array network from fluid of the set of sample droplets; and a second layer opposing the first layer and displaced from the first layer to define a region wherein droplets of the set of sample droplets can reside. In some variations, the system can additionally include an electronics subsystem coupled to at least one of the substrate and the electrode array network, and a control module in communication with the electronics subsystem, wherein the control module generates and manipulates the pattern of controlled electric fields. | 2017-02-09 |
20170038369 | DIGITAL PROTEIN SENSING CHIP AND METHODS FOR DETECTION OF LOW CONCENTRATIONS OF MOLECULES - A sensing device is provided that includes a tunnel junction created by forming a hole in a layered tunnel junction (for example). A chemically, well-defined surface may be formed by coupling affinity reagents to the electrodes, which, by these means, the surface may be configured to be selective for a particular analyte. | 2017-02-09 |
20170038370 | METHOD AND KIT FOR THE DETECTION OF MICROORGANISMS - There is provided a method of detecting an analyte in a sample. The method is based on colorimetry and also on the binding affinity between the analyte and a chemical substrate which may be a recognition receptor thereof. The method involves a support and a colored carrier. A kit for use in the detection is also provided. | 2017-02-09 |
20170038371 | COMBINATORIC ENCODING METHODS FOR MICROARRAYS - A method for determining a presence or absence of one or more target analytes in a sample includes contacting the sample with an array of particles comprising at least first and second particle subsets disposed therein with a known particle number ratio with respect to each other. The first particle subset has at least one binding site configured to bind with a first target analyte and the second particle subset has at least one binding site configured to bind with a second, different target analyte. Changes are detected in a detectable signal emitted by the particles after contacting the sample with the array. A number of the particles that emit the change in the detectable signal are counted and this number is compared to the known particle number ratio of the subsets so as to determine the presence or absence of the one or more of the target analytes. | 2017-02-09 |
20170038372 | Methods And Devices For Performing Biological Assays Using Magnetic Components - A method for retrieving magnetic components from a sample solution includes obtaining an array plate with a sample surface that includes a plurality of sample regions and a surrounding region. A first solution is located on a sample region of the plurality of sample regions. The first solution includes a plurality of magnetic components. A separation layer that includes one or more protrusions is placed so that at least a respective protrusion of the one or more protrusions is at least partially immersed in the first solution. A first magnetic device is placed within the respective protrusion. At least a portion of the plurality of magnetic components is retrieved from the first solution by concurrently moving the separation layer and the magnetic device so that the respective protrusion ceases to be at least partially immersed in the first solution on the sample region. | 2017-02-09 |
20170038373 | BIOSENSOR USING MAGNETIC PARTICLES FOR PATHOGEN DETECTION - There is provided a biosensor for detecting pathogens in a sample. The detection is based on colorimetry. The biosensor comprises one or more particle supports and a magnetic material attached to a planar support. The biosensor embodies magnetic particles that are functionalized using a chemical substrate specific to the pathogens to be detected. The sensor may allow for a simultaneous detection of a plurality of pathogens in the sample. Also, the sensor may be disposable. Moreover, the sensor may be integrated in a portable detection device. | 2017-02-09 |
20170038374 | METHODS FOR ISOLATING A TARGET ANALYTE FROM A HETEROGENOUS SAMPLE - The invention generally relates to methods of using compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen, and magnets to isolate a pathogen from a body fluid sample. | 2017-02-09 |
20170038375 | COMPLEX FOR DETECTING TARGET MATERIAL AND METHOD OF DETECTING TARGET MATERIAL USING THE SAME - The present disclosure relates to a complex for detecting a target material comprising upconverting nanoparticles; and at least one target material specific aptamer-quencher, connected through a linker with the upconverting nanoparticles, a method of preparing the same, a kit for detecting a target material comprising the same, and a method of detecting a target material using the same. | 2017-02-09 |
20170038376 | SULFONATED POLYESTER-METAL NANOPARTICLE COMPOSITE TONER FOR COLORIMETRIC SENSING APPLICATIONS - A toner composite material includes toner particles that include a sulfonated polyester and a wax and metal nanoparticles disposed on the surface of the toner particles. A method includes providing such toner composite materials, fusing the material to a substrate and covalently linking a ligand to the surface of the silver nanoparticles via a thiol, carboxylate, or amine functional group. Detection strips include a substrate and such toner composite materials fused on the substrate. | 2017-02-09 |
20170038377 | USE OF A COLORANT IN ORDER TO IMPROVE SIGNAL DETECTION IN AN ANALYSIS METHOD - The invention relates to the use of at least one colorant in order to improve the detection of a signal corresponding to the presence of an analyte in a dot analysis method, in particular when the detection of the signal takes place in the presence of a liquid phase. The invention also relates to a dot analysis method that can be used to improve the detection of a signal corresponding to the presence of an analyte, in the presence of a liquid phase comprising at least one colorant. | 2017-02-09 |
20170038378 | GLYCAN ARRAYS ON PTFE-LIKE ALUMINUM COATED GLASS SLIDES AND RELATED METHODS - Aluminum coated glass slides provide a novel glycan array platform. Specifically, aluminum coated glass slides increase sensitivity of fluorescent based assay methods. Additionally, aluminum coated glass slides allows for mass spectroscopic analysis of carbohydrates and provide a platform for examining activity of cellulases. The unique properties of ACG slides include: 1) the metal oxide layer on the surface can be activated for grafting organic compounds such as modified oligosaccharides; 2) the surface remains electrically conductive, and the grafted oligosaccharides can be simultaneously characterized by mass spectrometry and carbohydrate-binding assay; and 3) the slides are more sensitive than transparent glass slides in binding analysis. | 2017-02-09 |
20170038379 | METHOD AND SYSTEM FOR INTERACTION ANALYSIS - A method for evaluation of an interaction between an analyte in a fluid sample and a ligand immobilized on a sensor surface of a biosensor, which comprises the steps of:
| 2017-02-09 |
20170038380 | INTEGRATED MICROARRAY PRINTING AND DETECTION SYSTEM FOR MOLECULAR BINDING ANALYSIS - A method and system for analysis of protein interaction kinetics in microarray or whole-cell based formats includes positioning a sensor chip on a prism. The sensor chip is spotted with a plurality of target molecules. A movable printer head deposits a plurality of analyte droplets on predefined regions of the sensor chip surface. A light source transmits light through the prism to excite surface plasmon resonance on the sensor chip surface, whereby the plurality of target molecules bound to the upper surface are changing the SPR resonance angle and therefore the intensity of the reflected beam. A detector receives reflected light transmitted through the prism from the bottom surface. Signals from the detector are received and processed into kinetic data and microarray labeled data to determine molecular interactions and binding kinetic properties for the plurality of analyte droplets. | 2017-02-09 |
20170038381 | METHODS AND COMPOSITIONS FOR IDENTIFYING PATIENT POPULATIONS FOR DIAGNOSIS AND TREATMENT OF TLR4-DEPENDENT DISORDERS - This invention relates generally to methods and compositions for identifying patient populations for diagnosis and treatment of Toll-like Receptor 4 (TLR4)-dependent disorders. In particular, the invention relates to detecting levels of anti-citrullinated protein antibodies (ACPA) and citrullinated peptides to identify patients having a TLR4-dependent disease and to identify patients who are likely to respond to anti-TLR4 therapy. The invention also relates to methods of treating, delaying the progression of, or otherwise ameliorating a symptom of a disorder in patients with elevated levels of ACPA and citrullinated peptides using agents that interfere with or otherwise antagonize TLR-4 signaling, including neutralizing anti-TLR4 antibodies. | 2017-02-09 |
20170038382 | METHODS AND COMPOSITIONS FOR IMMUNE DIS-INHIBITION - The disclosure provides methods and compositions for immune dis-inhibition. In certain embodiments, the methods comprise administering an effective amount of an agent that decreases the amount of a soluble cytotoxic receptor or inhibits its activity. In certain embodiments, the agent inhibits the proliferation, growth, or survival of cancer cells, decreases the size or a tumor, or inhibits tumor growth. | 2017-02-09 |
20170038383 | METHODS, COMPOSITIONS, AND KITS FOR DETECTION OF ASPERGILLOSIS - Provided herein are methods for detecting an | 2017-02-09 |
20170038384 | TREATMENT OF TUMORS EXPRESSING MUTANT P53 - PDGFRb inhibitors and the use of such inhibitors to treat mutant p53-expressing tumors are described. The present disclosure encompasses the discovery that mutant p53-induced upregulation of the platelet-derived growth factor receptor b (PDGFRb) contributes to invasion and/or metastasis of tumors expressing mutant p53. Specifically, the present disclosure encompasses the discovery that mutant p53 can disrupt a p73/NF-Y complex (which can repress PDGFRB transcription), leading to transcription of PDGFRb. The present disclosure therefore provides, at least in part, PDGFRb modulators (e.g., activators or inhibitors) for use in medicine, and specifically in diagnosis, treatment and/or prevention (e.g., delay of onset) of certain disorders, e.g., cancer. | 2017-02-09 |
20170038385 | G-Alpha Interacting Vesicle Associated Protein (GIV) as a Predictive Marker in Stage II Colorectal Cancer - Provided herein are methods of analyzing stage II colorectal cancer (CRC) samples (such as those that are mis-match repair proficient, pMMR), by scoring G-alpha interacting vesicle associated protein (GIV, also known as girdin) full-length (GIV-fl) expression in combination with lymphovascular invasion (LVI) status or clinical variables. The disclosed methods can be used to identify GIV-fl expressing tumors that are likely to recur (high risk) and those that are not likely to recur (high risk). Subjects identified as having a high risk CRC can be selected to receive chemotherapy or biotherapy for the CRC. Thus, in some examples, the disclosed methods can be used to identify CRC tumors that are likely to respond to chemotherapy or biotherapy. Also provided are computer implemented methods, systems, and kits that can be used with these methods. | 2017-02-09 |
20170038386 | METHODS AND BIOMARKERS FOR ANALYSIS OF COLORECTAL CANCER - The present invention relates to methods and biomarkers (e.g., protein biomarkers) for detection of colorectal cancer in biological samples (e.g., tissue samples, biopsy samples, stool samples, blood samples, plasma samples, serum samples). In some embodiments, methods and biomarkers of the present invention find use in detection of colon cancer, providing a prognosis to colorectal cancer patients, and in companion diagnostics. | 2017-02-09 |
20170038387 | METHODS FOR TREATING CHRONIC LYMPHOCYTIC LEUKEMIA AND THE USE OF BIOMARKERS AS A PREDICTOR OF CLINICAL SENSITIVITY TO IMMUNOMODULATORY THERAPIES - A method of identifying a subject having chronic lymphocytic leukemia (CLL) who is likely to be responsive to a treatment compound, comprising obtaining a first sample and a second sample from the subject having CLL; administering 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione (Compound A) to the first sample and administering lenalidomide to the second sample; determining the level of a biomarker in the first sample and determining the level of the biomarker in the second sample; and diagnosing the subject as being likely to be responsive to the treatment compound if the level of the biomarker in the first sample is different from the level of the biomarker in the second sample. | 2017-02-09 |
20170038388 | DIAGNOSTIC METHODS FOR LIVER DISORDERS - The present invention relates to methods of diagnosing a liver disorder in a patient, as well as methods of monitoring the progression of a liver disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a chemotherapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein. | 2017-02-09 |
20170038389 | METHOD TO SCREEN OUT FALSE POSITIVES IN A CIRCULATING TUMOR CELL ASSAY - Provided herein are methods of screening a patient sample in a circulating tumor cell assay for false positives as well as methods of performing a circulating tumor cell detection assay. Also provided herein are methods of simultaneously identifying, and methods of distinguishing between, a circulating tumor cell and a circulating endothelial cell in a patient sample. Methods of treating a patient with cancer comprising screening for false positives in a circulating tumor cell assay and administering to the patient an anti-cancer therapy are further provided. | 2017-02-09 |