| 06th week of 2012 patent applcation highlights part 38 |
| Patent application number | Title | Published |
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| 20120034557 | Method for preparing alignment mark for multiple patterning - A method for image pattern recognition in a multi-image patterning scheme is described. The method includes forming a first feature pattern on a substrate using a lithographic process, and forming a second feature pattern on the substrate using the lithographic process. The method further includes forming an inspection alignment mark on the substrate to distinguish the first feature pattern from the second feature pattern. The inspection alignment mark comprises a negative tone pattern having a first alignment structure aligned with at least a portion of the first feature pattern and a second alignment structure aligned with at least a portion of the second feature pattern, wherein the first alignment structure is independent from the second alignment structure. | 2012-02-09 |
| 20120034558 | PHOTOLITHOGRAPHY MATERIAL FOR IMMERSION LITHOGRAPHY PROCESSES - A photolithography material is provided. The photolithography material is a surface modifying material. The photolithography material includes a polymer (e.g., fluorine polymer) that includes less than approximately 80% hydroxyl groups. In an embodiment, the photolithography material includes less than approximately 80% fluoro-alcohol functional units. Methods of using the photolithography material include as an additive to a photoresist or topcoat layer. The photolithography material may be used in an immersion lithography process. | 2012-02-09 |
| 20120034559 | ACTINIC-RAY- OR RADIATION-SENSITIVE RESIN COMPOSITION, RESIST FILM THEREFROM AND METHOD OF FORMING PATTERN THEREWITH - Provided is an actinic-ray- or radiation-sensitive resin composition, includes a resin (P) containing a repeating unit (A) that when exposed to actinic rays or radiation, is decomposed to thereby generate an acid and a repeating unit (B) with a structure that when acted on by an acid, is decomposed to thereby increase its solubility in an alkali developer, and a compound (U) structured so that when the composition is formed into a film, the compound is unevenly distributed in a surface of the film. | 2012-02-09 |
| 20120034560 | RADIATION-SENSITIVE RESIN COMPOSITION, METHOD FOR FORMING RESIST PATTERN AND POLYMER - A radiation-sensitive resin composition includes (A) a polymer that includes a structural unit (I) including a group shown by the following formula (i), (B) a photoacid generator, and (C) a polymer that has a fluorine atom content lower than that of the polymer (A), and includes an acid-labile group. The polymer (A) preferably includes a structural unit shown by the following formula (1) as the structural unit (I). It is preferable that X in the formula (1) represent a divalent or trivalent chain-like hydrocarbon group or alicyclic hydrocarbon group. | 2012-02-09 |
| 20120034561 | RESIST POLYMER AND RESIST COMPOSITION - The resist polymer of the present invention comprises a specific constitutional unit having a cyano group, a constitutional unit having an acid-dissociable group, and a specific constitutional unit having a lactone skeleton. When the above polymer is used as a resist resin in DUV excimer laser lithography or electron beam lithography, it exhibits high sensitivity and high resolution, and provides a good resist pattern shape, having a small degree of occurrence of line edge roughness or generation of microgels. | 2012-02-09 |
| 20120034562 | COATING COMPOSITION FOR USE WITH AN OVERCOATED PHOTORESIST - In a first aspect, organic coating compositions are provided, particularly spin-on antireflective coating compositions, that contain a polyester resin component. In a further aspect, coating compositions are provided that contain a resin component obtained by polymerization of a multi-hydroxy compound. Coating compositions of the invention are particularly useful employed in combination with an overcoated photoresist layer to manufacture integrated circuits. | 2012-02-09 |
| 20120034563 | RESIST COMPOSITION AND METHOD FOR PRODUCING RESIST PATTERN - A resist composition contains; a resin having a structural unit derived from a compound represented by the formula (a); and an acid generator represented by the formula (B1). | 2012-02-09 |
| 20120034564 | POSITIVE RESIST COMPOSITION AND PATTERN FORMING METHOD - A positive photosensitive composition includes:
| 2012-02-09 |
| 20120034565 | Lithographic printing plate precursor - A lithographic printing plate precursor comprising a coating provided on a support having a hydrophilic surface, the coating containing thermoplastic polymer particles and an infrared radiation absorbing dye characterized in that the coating further comprises a phenolic stabilizer. | 2012-02-09 |
| 20120034566 | MICRO-CHANNEL DEVICE AND METHOD FOR FABRICATING MICRO-CHANNEL DEVICE - A micro-channel device provided in a solution analysis system using pressure liquid feed comprises a plurality of straight-line channels and curved channels connecting the ends of the neighboring straight-line channels. The width w of each curved channel is smaller than the width t of each straight-line channel. The radius of curvature r of each curved channel is set so that the value of a expressed by formula (1) is equal to or smaller than the value of a at a local maximum point of the theoretical step height H expressed by formula (2) and based on the shape of the curved channel. | 2012-02-09 |
| 20120034567 | AUTOMATIC GAS TORCH IGNITION IN AN OXYGEN RICH ENVIRONMENT - A method of starting an auto-ignition gas torch includes increasing a flow of oxygen above zero and increasing a flow of fuel gas to a level lower than the flow of oxygen for improved start reliability. In one form, the flow of oxygen is from about two times to about six times higher than the flow of fuel gas. | 2012-02-09 |
| 20120034568 | COMBUSTION AIR CONTROL - Embodiments of the present disclosure include devices and methods for controlling combustion air. For example, in one embodiment, a method for controlling combustion air includes determining an amount of leaking air in a boiler, determining a constant that depends on a heating value of a fuel in the boiler, and adjusting an amount of controlled air supplied to the boiler. | 2012-02-09 |
| 20120034569 | SENSOR CONTROLLER - A sensor controller for a particulate matter detection sensor includes a heater configured to heat an attachment portion so as to burn and remove particulate matter attached to the attachment portion, a learning portion for obtaining a sensor detection value immediately after burning and removing the particulate matter due to heating of the heater. The leaning portion calculates a sensor standard value based on the obtained sensor detection value in a state where the particulate matter is removed, and stores the sensor standard value as a learning value. Furthermore, a correcting portion corrects the sensor detection value based on the sensor standard value stored by the learning portion. | 2012-02-09 |
| 20120034570 | SUBSTRATE PROCESSING APPARATUS AND METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE - A substrate processing apparatus reduces over-heating of a substrate transfer robot and suppresses deterioration of reliability or lifespan of the substrate transfer robot. The substrate processing apparatus includes a transfer chamber having a substrate transferred thereinto under a negative pressure; a process chamber connected to the transfer chamber and configured to heat the substrate; a transfer robot installed in the transfer chamber and configured to transfer the substrate into and out of the process chamber; and a cooling unit configured to cool an inner wall of the transfer chamber. | 2012-02-09 |
| 20120034571 | DEVICES, SYSTEMS, AND METHODS FOR RECYCLING PLASTIC - Systems for recycling waste plastic can include cartridges that are selectively sealable. Some cartridges can have elongated receptacles that improve heat transfer to plastic feedstock within the cartridges. | 2012-02-09 |
| 20120034572 | SURFACE MODIFICATION FOR ENHANCED SILANATION OF CERAMIC MATERIALS - A coated medical implant, such as a coated dental component, is provided, the coated medical implant including a substrate surface formed of a material comprising available hydroxyl groups and a silicon oxide coating layer chemisorbed on the substrate surface. A method for the preparation of such coated implants is also provided, the method involving application of the silicon oxide coating layer to the substrate surface by chemical vapor deposition. A dental structure is also provided, which includes a first dental component having a substrate surface formed of a material comprising available hydroxyl groups; a silicon oxide coating layer chemisorbed on the substrate surface; a silane coupling agent overlying and covalently attached to the silicon oxide layer; a dental cement overlying and coupled to the silane coupling agent; and a second dental component having a surface bonded to the dental cement. | 2012-02-09 |
| 20120034573 | Medical, in Particular Dental, Diagnostic Device Having Image Capture Means - A medical, in particular dental, diagnostic device having means for image capture and a hand piece that has a window located in the optical path of the means for image capture, wherein there are means for heating the window formed by a resistance heater. | 2012-02-09 |
| 20120034574 | DENTAL IMPLANT SYSTEM AND METHOD - A dental implant system and method for inserting a threaded implant in both edentulous and partially edentulous space of a patient's jaw bone in the form of a threaded implant having at least one hole adapted along its longitudinal axis for insertion of an abutment post and a drilling gauge having leg portions adapted for use with the implant. Any one of the leg portions includes a hole equally aligned with thee hole of the threaded implant when placed proximate the gauge. The implant is inserted into the hole drilled in the jaw bone. The hole of the drilling guage marks the location where a hole will be drilled vertically into the jaw bone through which an abutment post would be inserted and screwed into the hole of the implant, for subsequent placement of a prosthetic tooth. | 2012-02-09 |
| 20120034575 | COMBINATION ROTATING DENTAL CLEANING BRUSH AND PASTE DEVICE - The combination rotating dental cleaning brush and paste device. The device includes a housing having a rotating shaft therethrough. A compressible tube has two opposed ends, a first end which is rotated by the shaft and a second end having an opening therethrough. A brush is integral with, connected to, and rotated by the second end of the tube. Compression of the compressible tube forces dental paste inside of the tube out of an opening in the second end of the tube and onto the brush. | 2012-02-09 |
| 20120034576 | DENTAL CLEANING DEVICE - A dental cleaning device ( | 2012-02-09 |
| 20120034577 | DENTAL IMPLANT WITH OSTEOINDUCTIVE CARRIER SYSTEM - A dental implant has a first coronal portion having a first width and a second apical portion having a second smaller width, where a taper between the coronal and the apical portions is of constant slope. A threaded arrangement on an outer surface of the dental implant is provided with an osteoinductive growth stimulating substance located on the outer surface of the dental implant. | 2012-02-09 |
| 20120034578 | ONE PIECE DENTAL IMPLANT AND USE THEREOF IN PROSTODONTIC AND ORTHODONTIC APPLICATIONS - The specification describes one-piece dental implants comprising a threaded shaft, optionally a non-circular abutment and a head having a shape which is capable of accepting a keeper cap or an O-ring, or which is capable of accepting and retaining a dental wire. The implants have dimensions that permit their use in a non-surgical method of insertion into bone, and are useful in both prosthodontic and orthodontic applications. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims. | 2012-02-09 |
| 20120034579 | APPARATUS FOR EVACUATION OF ROOT CANAL - In an endodontic procedure, after the working of a root canal by instruments to remove material and shape the walls of the canal, irrigant is supplied via a microcannula. A vacuum is applied via a tube which is inserted partway down the root canal. The tube and microcannula pass through a material created by a standard dental filling material of a composite nature which provides a seal at a position near the top of the coronal opening. The irrigant is supplied in a manner sufficient to ensure delivery to a side vent of the microcannula. The vacuum at the end of tube draws the irrigant and debris up from the apex of the root canal into the tube. The side vent may have a plurality of more round holes, a diagonal slit, or a U shaped slit, or any other shape. The vent opening should not extend more than approximately 0.75 mm from the closed spherical tip of the microcannula, it must be burr free and the opening must be smaller than the internal diameter of the microcannula | 2012-02-09 |
| 20120034580 | SYSTEMS AND METHODS FOR FORMALIZED INTEGRATION OF CREATIVE MOVEMENT, RHYTHM AND EDUCATION - Methods and systems are provided for teaching educational concepts through creative activities such as movement and vocalization. A systematic procedure is provided for lesson structures including (1) students experience a lesson through a first activity involving movement and/or rhythm, (2) students experience a lesson through a second activity involving movement and/or rhythm, (3) student observation and discussion, and (4) creative assessment. These steps may be performed in various orders to adapt to various educational concepts and learning environments. | 2012-02-09 |
| 20120034581 | LANGUAGE LEARNING SYSTEM, LANGUAGE LEARNING METHOD, AND COMPUTER PROGRAM PRODUCT THEREOF - A language learning system including a storage module, a feature extraction module, and an assessment and diagnosis module is provided. The storage module stores training data and an assessment decision tree generated according to the training data. The feature extraction module extracts pronunciation features of a pronunciation given by a language learner. The assessment and diagnosis module identifies a diagnosis path corresponding to the pronunciation of the language learner in the assessment decision tree and outputs feedback information corresponding to the diagnosis path. Thereby, the language learning system can assess and provide feedback information regarding words, phrases or sentences pronounced by the language learner. | 2012-02-09 |
| 20120034582 | READING TEACHING METHOD - A method of teaching a person to read, based on short, intense reading sessions or lessons. After a suitable evaluation, a teacher establishes a plurality compilation of reading elements, starting with letters and which may progress in complexity to words. The student is positioned in close physical proximity to the teacher and reads the compilations aloud to an audible or sensible beat to promote a pace of reading. Reading speed of accurate reading may then be graphically illustrated to the student. Sessions including the above steps are performed in a short, intense period of perhaps fifteen minutes. Periodic sessions of the above steps may be repeated periodically such as two sessions per week for six to eight weeks. | 2012-02-09 |
| 20120034583 | VETERINARY EXAM PREPARATION ON MOBILE DEVICES - An apparatus for use in a process to assist a user to prepare for a veterinary examination includes a computer-readable non-transitory medium storing a veterinary exam practice question, and a plurality of answers that correspond to the veterinary exam practice question, and a processor configured to receive a request from a mobile device, access the medium to retrieve the veterinary exam practice question and the plurality of answers in response to the received request, and provide the retrieved veterinary exam practice question and the plurality of answers for display on the mobile device. | 2012-02-09 |
| 20120034584 | Peered Proctoring - Systems and methods described herein utilize a distributed server network to allow for the real-time distribution of copies of a data stream uploaded from a computing device. The uploaded data stream corresponds to an environment surrounding a user (exam taker) of the computing device during execution of a testing routine for an examination. Providing copies of the data stream in real-time allows proctors as well as other test assessment authorities to ‘peek in’ on the exam taker's environment during the exam. As a result, the environment surrounding the exam taker can be monitored in real-time to determine whether any visual or audio activity in the environment constitutes activity not in accordance with the exam protocol. Following an affirmative determination that the exam taker violated an exam taking protocol, a proctor or other test assessment authority can then make a final or early decision regarding disciplinary action. | 2012-02-09 |
| 20120034585 | WATER SKIER TRAINING DEVICE AND METHOD OF USING THE SAME - A floatable skier training device that includes a first floatable support comprising a first leading end and a second end, a second floatable support a first leading end and a second end, a seat (e.g., an arcuate seat) extending from the first floatable support to the second floatable support, the arcuate seat having a first forward section, a second rearward section, a top and a bottom, when the device is placed on a body of water, the bottom forms an angle with the surface of the body of water that is no greater than 45 degrees, and a method of using the same to allow a user to start from a position above the water. | 2012-02-09 |
| 20120034586 | PULSE SIMULATOR AND A METHOD FOR SIMULATING PULSE - The present invention relates to an improved pulse simulator and to an improved method for simulating pulse. It comprises a palpation conveyor connected with a flexible pump means. The flexible pump is operatively coupled to a solenoid arranged about a fixed core. The solenoid is magnetized and demagnetized by an electrical energy source causing back and forth motion of the solenoid, with consequential expansion and contraction of the flexible pump means, thereby releasing fluid in back and forth direction to the palpation conveyor for generating pulse sensation. | 2012-02-09 |
| 20120034587 | PHSYSIOLOGICAL SIMULATOR FOR USE AS A BRACHIAL PLEXUS NERVE BLOCK TRAINER - Conductive elastomeric circuits representing three brachial plexus nerve bundles and sheaths that surround each nerve bundle are embedded in a neck tissue portion of a simulated physiological structure for use in training and evaluating a user in performing a brachial plexus nerve block procedure. An electrically conductive probe is provided for the user to insert within a neck tissue structure and to attempt to contact a sheath, but not the nerve bundle within the sheath of a desired nerve bundle. The probe is electrically coupled to a voltage source. A simulated nerve stimulator is connected to the conductive elastomeric circuits (electrically insulated from each other) and detects when the probe contacts a nerve or sheath, producing an output signal. The output signal is input to a computer that displays a simulated ultrasound image hi-lighting a nerve and/or sheath that has been contacted by the probe, for evaluating the user's performance. | 2012-02-09 |
| 20120034588 | DEVICE FOR SIMULATING VARIABLE LUNG COMPLIANCE - Device for simulating variable lung compliance, comprising a structure having two main components ( | 2012-02-09 |
| 20120034589 | METHOD AND APPARATUS FOR EDUCATING AND INFLUENCING AN INDIVIDUAL - A method and apparatus for influencing a person to develop, accept and/or understand a concept, position or idea using questioning, including a technique sometimes known as the Socratic Method. A universe of question and answer subsets comprising questions and respective multiple choice answers to each question designed in advance, arranged and inter-connected on a stand-alone computer, a computer on a local area network or computer network, or any computer network and displayed in such a way as to allow the participant to follow the individual's own path by selecting answers he accepts, which tend to logically lead the individual toward agreement and or understanding on the subject. | 2012-02-09 |
| 20120034590 | AUDIENCE RESPONSE SYSTEM DATA COMMUNICATION INCORPORATING NON USER SELECTION SIGNALS - A method for a response device to wirelessly communicate data in an audience response system having a plurality of response devices includes transmitting a first signal, receiving a first acknowledgement signal indicating to the response device to transmit non user selection signals. The method further includes transmitting a non user selection signal in response to the first acknowledgement signal and receiving a second acknowledgement signal indicating to the response device to cease transmitting non user selection signals. | 2012-02-09 |
| 20120034591 | STUDENT PERFORMANCE ASSESSMENT - Described are computer-based methods and apparatuses, including computer program products, for student performance assessment. In some examples, a method includes automatically generating an assessment for a plurality of students based on a selection of assessment information; receiving a plurality of assessment responses from the plurality of students in response to the generated assessment; transmitting requests for at least two preliminary assessment scores for each of the plurality of assessment responses; receiving at least two preliminary assessment scores for each of the plurality of assessment responses; determining if each of the at least two preliminary assessment scores for each of the assessment responses match a criteria; transmitting a request for an additional preliminary assessment score for the assessment response if the at least two preliminary assessment scores match the criteria; and generating a final assessment score for each of the assessment responses. | 2012-02-09 |
| 20120034592 | DUMMY COMPRISING A POSITIONING SYSTEM FOR ASSISTANCE IN RESCUE OPERATIONS FOR PEOPLE AND SHIPS IN THE SEA - A device for searching for shipwrecks and ships during rescue operations includes a dummy, in general terms, or more loosely, any type of model representing, with a minimum amount of accuracy, the main physical characteristics of a person, such as weight, size, shape, dimensions, etc. The device is designed as a dummy or any other type of model simulating a human body, that imitates, as accurately as possible, the main physiological characteristics largely determining the behaviour of a body in the water, such as dimensions, shape, weight, floatability, clothes, etc. Furthermore, the dummy includes a positioning system such as a GPS and a signal transmitter enabling its exact position to be indicated to a receiver at any moment, a “lung” compartment, which is prefereably located in the chest of the dummy and provided with an opening valve containing an inflatable impermeable bag, a compressed gas reservoir, and an activation system having a programmable timer, and, optionally, a signal receiver enabling remote activation. | 2012-02-09 |
| 20120034593 | CYCLIC PEPTIDES WITH AN ANTI-PARASITIC ACTIVITY - The present invention relates to a method for preparing a cyclic peptide with antiparasite activity and anticancer activity. The invention also relates to this peptide as an antiparasite agent, for example in the treatment of toxoplasmosis and as an anticancer agent. The invention also relates to the use of this cyclic peptide for treating organs ex vivo before transplantation. | 2012-02-09 |
| 20120034594 | Methylocystis Strain SB2 Materials and Methods - The present disclosures provides isolated or purified compounds, each of which bind to a metal atom. Generally, the compounds are small in size (e.g, molecular weight of less than about 1 kDa) and peptidic in nature, inasmuch as the compounds comprise amino acids. In some embodiments, the compound comprises a structure of Formula I: | 2012-02-09 |
| 20120034595 | Enriched stem cell and progenitor cell populations, and methods of producing and using such populations - The present invention provides a novel method to isolate and expand pure progenitor/stem cells from a primary tissue explant, which produces a population enriched in multipotent functional progenitor/stem cells free of contaminating fibroblasts and other cell types. Cardiac progenitor/stem cells isolated by this method maintain their self-renewal and clonogenic character in vitro and differentiate into normal cells in myocardium, including cardiomyocytes, endothelial cells, and smooth muscle cells, after transplantation into ischemic hearts. The present invention also includes substantially pure populations of multipotent progenitor/stem cells, e.g., cardiac progenitor/stem cells, and their use to treat and prevent diseases and injuries, including those resulting from myocardial infarction. | 2012-02-09 |
| 20120034596 | DEVICE FOR AUTOMATICALLY CULTIVATING CELLS IN PARALLEL - A device for automatically cultivating cells in parallel in cell culture vessels, in particular microtiter (MT) plates ( | 2012-02-09 |
| 20120034597 | METHODS OF MONITORING TREATMENT OF AVIREMIC HIV-INFECTED PATIENTS - Methods of monitoring the efficacy of intensified highly active anti-retroviral therapy (HAART) treatment in aviremic Human Immunodeficiency Virus (HIV)-infected patients. | 2012-02-09 |
| 20120034598 | Real-Time Detection of Influenza Virus - The present invention provides system and methods for detecting an analyte indicative of an influenza viral infection in a sample of bodily fluid. The present invention also provides for systems and method for detection a plurality of analytes, at least two of which are indicative of an influenza viral infection in a sample of bodily fluid. | 2012-02-09 |
| 20120034599 | SCREENING SYSTEMS UTILIZING RTP801 - RTP801 represents a unique gene target for hypoxia-inducible factor-1 (HIF-1). Down-regulation of the mTOR pathway activity by hypoxia requires de novo mRNA synthesis and correlates with increased expression of RTP801. | 2012-02-09 |
| 20120034600 | DECREASING POTENTIAL IATROGENIC RISKS ASSOCIATED WITH INFLUENZA VACCINES - Influenza viruses for use in preparing human vaccines have traditionally been grown on embryonated hen eggs, although more modern techniques grow the virus in mammalian cell culture e.g. on Vero, MDCK or PER.C6 cell lines. The inventor has realised that the conditions used for influenza virus culture can increase the risk that pathogens other than influenza virus may grow in the cell lines and have identified specific contamination risks. Suitable tests can thus be performed during manufacture in order to ensure safety and avoid iatrogenic infections. | 2012-02-09 |
| 20120034601 | Porous Materials for Biological Sample Collection - Methods, apparatuses, and systems for collecting samples using hybrid porous materials that include an organic material and an inorganic material. A method for sample collection includes contacting a hybrid porous material and a biological sample to the porous material. The hybrid porous material includes an inorganic material and an organic material. The method includes placing the porous material with the attached sample in a liquid medium, wherein the sample is separated from the porous material in the liquid medium to form a separated sample, and collecting the separated sample in the medium. | 2012-02-09 |
| 20120034602 | Recombinant Polymerases For Improved Single Molecule Sequencing - Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties can include enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased thermostability, increased accuracy, increased speed, increased readlength, and the like. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template. | 2012-02-09 |
| 20120034603 | LIGATION-BASED DETECTION OF GENETIC VARIANTS - The present invention provides assays systems and methods for detection of genetic variants in a sample, including copy number variation and single nucleotide polymorphisms. The invention preferably employs the technique of tandem ligation, i.e. the ligation of two or more fixed sequence oligonucleotides and one or more bridging oligonucleotides complementary to a region between the fixed sequence oligonucleotides. | 2012-02-09 |
| 20120034604 | USE OF BASIC PROLIN-RICH LACRIMAL GENE PRODUCTS, SUCH AS OPIORPHIN, AS A BIOMARKER - The present invention relates to the use of Basic Prolin-rich Lacrimal protein (BPLP) gene products, such as Opiorphin, for establishing a prognosis, a diagnosis or the monitoring of a pathological state or of treatment efficacy in a subject and the related method of use. | 2012-02-09 |
| 20120034605 | METHOD FOR DETECTION OF COLORECTAL TUMOR - Disclosed is a method for determining the presence or absence of a colorectal tumor, specifically colorectal cancer or colorectal adenoma, with high sensitivity and high specificity by employing the methylation of DNA as a measure. Also disclosed is a kit for carrying out the method. Specifically, measurement is made on the degree of methylation of one or more CpG sequences contained in the region lying between positions -477 to -747, more preferably a CGCG sequence contained in the region lying between positions -688 to -691, in TWIST1 gene ( | 2012-02-09 |
| 20120034606 | DETECTION OF SALMONELLA ENTERICA SUBSPECIES ENTERICA SEROVAR ENTERITIDIS IN FOOD AND ENVIRONMENTAL SAMPLES, METHODS AND COMPOSITIONS THEREFOR - Embodiments of the disclosure relate to compositions of isolated nucleic acid sequences, methods, workflows and kits of use thereof for detection of | 2012-02-09 |
| 20120034607 | Methods and apparatus for measuring analytes using large scale fet arrays - Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis. | 2012-02-09 |
| 20120034608 | MICRORNA AS A BIOMARKER OF PANCREATIC ISLET BETA-CELL ENGAGEMENT - MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression and which play important roles in many cell types, including as described herein, the pancreatic β-cell. Glucagon like peptide-1 (GLP-1), a hormone released from intestinal L-cells following meal intake, exerts pleiotropic effects on β-cell function including raising intracellular cAMP levels and now represents an important therapy for type 2 diabetes. Expression of miR-132 and miR212 is upregulated by CREB protein in response increased cAMP levels in the cell; therefore, methods for detecting and evaluating β-cell engagement by GLP-1 receptor agonists by monitoring miR-132 and miR-212 expression in a subject is described. The methods herein are particularly useful in the context of longitudinal clinical trials, such as those designed for testing the durability of any single or combination therapy in type 2 diabetes populations. Because the expression of these miRNAs is not affected by glucose, fatty acid, insulin, or β-cell function, monitoring miR-132 and miR-212 expression can be used to monitor the efficacy of any agent that effects an increase cAMP in β-cells. Such agents include for example, GLP-1, glucagon, GPR-119, and GIP receptor agonists; dipeptidyl peptidase IV (DPP IV) inhibitors; and phosphodiesterase inhibitors. | 2012-02-09 |
| 20120034609 | GENE DETECTION ASSAY FOR IMPROVING THE LIKELIHOOD OF AN EFFECTIVE RESPONSE TO AN EGFR ANTAGONIST CANCER THERAPY - The invention provides a method for more effective treatment of patients susceptible to or diagnosed with tumors overexpressing EGFR, as determined by a gene amplification assay, with an EGFR antagonist. Such method comprises administering a cancer-treating dose of the EGFR antagonist, preferably in addition to chemotherapeutic agents, to a subject in whose tumor cells erbB1 gene has been found to be amplified e.g., by fluorescent in situ hybridization. EGFR antagonists described include an anti-EGFR antibody. | 2012-02-09 |
| 20120034610 | IDENTIFICATION OF TOXIN-BINDING PROTEIN INVOLVED IN RESISTANCE TO CRY1 TOXINS, AND RELATED SCREENING METHODS - The subject invention relates in part to the surprising and unexpected discovery that insects that are resistant to | 2012-02-09 |
| 20120034611 | METHOD FOR DETECTING PRESUMED IGA NEPHROPATHY AND METHOD FOR SCREENING IGA NEPHROPATHY PATIENTS - Based on detection of | 2012-02-09 |
| 20120034612 | Methods and Kits for miRNA Isolation and Quantitation - The present invention is a kit and method for isolating and quantitating miRNA and to the use of such methods in the diagnosis and prognosis of disease. | 2012-02-09 |
| 20120034613 | Apparatus and Method for Testing Relationships Between Gene Expression and Physical Appearance of Skin - The disclosure is directed to apparatus and methods for testing relationships between gene expression and physical appearance of skin and methods of assessing the efficacy of skin anti-aging agents. | 2012-02-09 |
| 20120034614 | EARLY DETECTION OF PATHOGENS IN BLOOD - The present invention is a method of extracting infectious pathogens from a volume of blood including the steps of creating a fibrin aggregate confining the pathogens and introducing a fibrin lysis reagent to expose the pathogens for analysis. The fibrin lysis reagent is preferably composed of plasminogen and streptokinase frozen in coincident relation until the fibrin lysis reagent is needed whereby streptokinase enzymatically reacts with plasminogen to form plasmin upon thawing. The plasminogen is suspended in an aqueous salt solution prior to freezing including NaCl and Na | 2012-02-09 |
| 20120034615 | HIFU INDUCED CAVITATION WITH REDUCED POWER THRESHOLD - An apparatus for irradiating a liquid sample with acoustic energy to generate cavitation in the liquid sample is provided. The apparatus includes a source and is adapted to receive a cartridge in such a way, that the apparatus focuses the HIFU waves emitted from the source onto a liquid air interface that is present within the cartridge. This focusing is performed when the cartridge is inserted into a receiving section of the apparatus. | 2012-02-09 |
| 20120034616 | Method for Modulating Epithelial Stem Cell Lineage - The present invention relates to methods of modulating epithelial stem cell lineage by regulating the expression of Lef1 or a BMP inhibitor and/or the stability of β-catenin or the expression of a Wnt; regulating the expression or activity of GATA-3; or regulating BMPR1A activity either at the level of receptor expression or at the level of pathway activation. Methods of regulating E-cadherin, GATA-3, BMPR1A and HK1-hair keratin and methods of identifying agents which modulate the epithelial stem cell lineage are further provided. Such agents are useful for inhibiting or stimulating inner root sheath development or hair follicle formation. | 2012-02-09 |
| 20120034617 | ASSAYS FOR BACTERIAL DETECTION AND IDENTIFICATION - The invention herein generally relates to kits and methods for detecting the presence of a bacterium in a subject, for example, methicillin resistant | 2012-02-09 |
| 20120034618 | METHODS FOR CULTURE AND PRODUCTION OF SINGLE CELL POPULATIONS OF HUMAN EMBRYONIC STEM CELLS - We used ACCUTASE®, a commercially available cell detachment solution, for single cell propagation of pluripotent hESCs. Unlike trypsin dissociation, ACCUTASE® treatment does not significantly affect the plating efficiency of hESC dissociation into single cells. Cultures dissociated with ACCUTASE® to single cells at each passage maintain a higher proportion of pluripotent cells as compared to collagenase-passaged hESCs. ACCUTASE®-treated hESCs can be grown to a high density as monolayers, and yet retain their pluripotency. | 2012-02-09 |
| 20120034619 | METHOD OF DETERMINING THE OLIGOMERIC STATE OF A PROTEIN COMPLEX - A method of counting protein subunits to determine the oligomeric state of an oligomeric protein complex includes tagging and expressing the protein subunits with a mass/charge tag and selectively removing each mass/charge tag. The number of protein subunits of the oligomeric complex corresponds to the number of mass/charge tags removed. | 2012-02-09 |
| 20120034620 | COMPOSITIONS AND METHODS FOR ADHESION OF INTACT CELLS TO AN APPARATUS - Bio-adhesive compositions that include an extra-cellular matrix protein, bovine serum albumin conjugated with a fluorophore, and an aggregate are provided. The bio-adhesive composition may also include at least one component selected from the group consisting of collagen type IV, laminin, and chitosan. Also provided are methods of making the present compositions, that include taking a desired amount of extracellular matrix gel to liquid form of extracellular matrix; adding a desired amount of bovine serum albumin conjugated with a fluorophore; adding a desired amount of aggregate; and mixing. Further provided are methods for attaching cells to an apparatus using the present bio-adhesive compositions, and methods of attaching the present bio-adhesive compositions to an apparatus. Also provided are kits that include the present composition, components thereof or apparatuses, having the present composition attached thereto. | 2012-02-09 |
| 20120034621 | MICROORGANISM CONCENTRATION PROCESS AND DEVICE - A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration device comprising a sintered porous polymer matrix comprising at least one concentration agent that comprises an amorphous metal silicate and that has a surface composition having a metal atom to silicon atom ratio of less than or equal to 0.5, as determined by X-ray photoelectron spectroscopy (XPS); (b) providing a sample comprising at least one microorganism strain; and (c) contacting the concentration device with the sample such that at least a portion of the at least one microorganism strain is bound to or captured by the concentration device. | 2012-02-09 |
| 20120034622 | ACTIVATION AND MONITORING OF CELLULAR TRANSMEMBRANE POTENTIALS - The use of nanostructures to monitor or modulate changes in cellular membrane potentials is disclosed. | 2012-02-09 |
| 20120034623 | UP-CONCENTRATION OF ORGANIZ MICROOBJECTS FOR MICROSCOPIC IMAGING - A method of analyzing a sample fluid containing organic microobjects is proposed. The method comprises the steps of: up-concentrating (S | 2012-02-09 |
| 20120034624 | OSCILLATING IMMUNOASSAY METHOD AND DEVICE - The present invention provides apparatus and methods for the rapid determination of analytes in liquid samples by immunoassays incorporating magnetic capture of beads on a sensor capable of being used in the point-of-care diagnostic field. | 2012-02-09 |
| 20120034625 | Monoclonal Antibody Capable of Binding Integrin Alpha 10 Beta 1 - The present invention provides a monoclonal antibody or a fragment thereof binding to the extracellular I-domain of integrin alpha10beta1 and a hybridoma cell line deposited at the Deutsche Sammlung von Microorganismen and Zellkulturen GmbH under the accession number DSM ACC2583. Furthermore, the present invention also provides a monoclonal antibody or a fragment thereof binding to the extracellular I-domain of integrin alpha10beta1 produced by the hybridoma cell line deposited. Methods and uses of said antibody or a fragment thereof in identifying and selecting cells of a chondrogenic nature for treatment purposes, in particular for the identification and isolation of chondrocytes, mesenchymal progenitor cells and embryonic stem cells for tissue engineering of cartilage, or for identifying diagnostic and therapeutic tools in studying the biological role and the structural/functional relationships of the integrin alpha10beta1 with its various extracellular matrix ligands are also included. | 2012-02-09 |
| 20120034626 | Neoplasia-Specific Autoantibodies and Methods - ENOX2 proteins are growth-related cell surface proteins expressed specifically by cancer cells; they catalyze NADH oxidation and protein disulfide-thiol interchange reactions. Taught herein are IgM class autoantibodies specific to ENOX2 (tNOX) in a variety of cancer patient sera. Early cancer patients produce these autoantibodies as a possible defense mechanism. Because ENOX2 is bound to autoantibodies in patients, it is unavailable to bind conventional ENOX2-specific antibodies in standard ELISA assays, but two-dimensional gel electrophoresis dissociates ENOX2 protein from autoantibodies, allowing detection. Probing ENOX2 using cancer sera as a source of ENOX2 autoantibodies followed by horseradish peroxidase-coupled anti-human IgM allows visualization and detection of the ENOX2 autoantibody. ENOX2 autoantibodies from breast cancer sera reacts with the ENOX2 isoforms from, e.g., lung and ovarian cancer patient sera. ENOX2 autoantibodies enable cancer screening based both on autoantibody detection and autoantibody dissociation to allow for standard ELISA development as well as therapy. | 2012-02-09 |
| 20120034627 | Diagnosis of benign and cancerous growths by measuring circulation tumor stem cells and serum annexina2 - Provided herein is a method for diagnosing/prognosing a metastatic cancer in a subject by measuring and detecting one or more of CS-ANXA2, DCAMKL, Lgr5 or CS-ANAX2 and DCAMKL or CS-ANXA2 and Lgr5 positive circulating tumor stem cells in the subject's blood or plasma. Also provided is a method for distinguishing the presence of early stage primary cancer from advanced stage metastatic cancer in the subject by measuring and detecting AnnexinA2, CS-ANXA2 and DCAMKL−1 or Lgr5 in the blood or plasma. In addition, there is provided a method for distinguishing the presence of benign, pre-cancerous tumorous growths or cancerous tumors in the subject by measuring and detecting AnnexinA2 and circulating tumor stem cells positive for CS-ANXA2 and DCAMKL or CS-ANXA2 and Lgr5 in the blood or plasma. | 2012-02-09 |
| 20120034628 | STANDARDIZED EVALUATION OF THERAPEUTIC EFFICACY BASED ON CELLULAR BIOMARKERS - The present invention provides materials and methods for predicting the response of a disease state to a therapeutic agent. A targeting moiety specific for a biological marker is labeled with a reporter moiety and used to analyze cells characteristic of the disease state. The output of the reporter moiety, which may be fluorescence intensity, is compared to the output of reference standard analyzed under similar or identical conditions. The use of a reference standard allows biomarker reporting to be normalized. Biomarker values can then be correlated from sample to sample and from laboratory to laboratory based on quantitative calibration on a universal reference standard. | 2012-02-09 |
| 20120034629 | PREDICTION OF NON-FATAL AND FATAL ATHEROTHROMBOTIC EVENTS - The present invention relates to methods and systems for the prediction of atherothrombotic events in human subjects. Preferably the human subjects are afflicted with a cardiovascular disease, such as end-stage renal disease. Methods and systems of the invention are particularly suited to predict atherothrombotic events in patients on hemodialysis. | 2012-02-09 |
| 20120034630 | Circovirus Sequences Associated With Piglet Weight Loss Disease (PWD) - The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a PWD circovirus, also are provided. Method for selecting compounds capable of modulating the viral infection are further provided. Pharmaceutical, including vaccine, compositions for preventing and/or treating viral infections caused by PWD circovirus and the use of vectors for preventing and/or treating diseases also are provided. | 2012-02-09 |
| 20120034631 | ANTI-LYSOPHOSPHOLIPID ANTIBODY DESIGN USING ANTIBODY STRUCTURES - The present invention provides crystalline forms of an anti-LPA antibody or fragment thereof, which may further comprise a lipid ligand of said antibody and/or salts, metals, or co-factors. Methods for making such crystals and co-crystals are provided, as are methods of using structural information in antibody design or optimization. Methods for designing a humanized antibody to a lipid are provided. These methods may be performed in silico and may be intended to enhance binding affinity of an antibody to its original target lipid, and/or to alter binding specificity. Optimized variant anti-LPA antibodies are also provided. | 2012-02-09 |
| 20120034632 | TWO-PHASE OPTICAL ASSAYS FOR ANALYTES OF NO INTRINSIC OPITCAL CONTRAST - Methods and kits for performing a two-phase optical assay for one or more than one analyte without intrinsic optical contrast in a sample are disclosed. The method requires use of a functionalized microparticle immobilized with two or more than functional components and an additional set of one or more than one functional component. The assay can be performed in one single container and does not need a wash step. | 2012-02-09 |
| 20120034633 | MAGNETIC IMMUNOSENSOR AND METHOD OF USE - The present invention provides apparatus and methods for the rapid determination of analytes in liquid samples by immunoassays incorporating magnetic capture of beads on a sensor capable of being used in the point-of-care diagnostic field. | 2012-02-09 |
| 20120034634 | MODIFIED LUCIOLA CRUCIATA LUCIFERASE PROTEIN - A codon optimized and stabilized luciferase gene based upon the sequence of the natural luciferase gene isolated from | 2012-02-09 |
| 20120034635 | METHOD FOR AMPLIFYING ADENOSINE TRIPHOSPHATE AND METHOD AND REAGENT FOR DETECTING THE CONCENTRATION OF MICROORGANISMS - A method for amplifying adenosine triphosphate is provided, including mixing adenosine triphosphate sulfurylase, adenosine 5′ phosphosulfate, adenylate kinase, uridine triphosphate, acetate kinase, acetyl phosphate, luciferin and luciferase in the presence of ATP to form a mixture, and reacting the mixture to amplify ATP. A method and reagent for detecting a concentration of microorganisms are also provided. | 2012-02-09 |
| 20120034636 | CHEMICAL SENSING DEVICE - This invention relates to a chemical sensing device for detecting an analyte. The device comprises a light source, at least one luminescent reagent which is capable of luminescing when irradiated by the light source wherein the luminescence of the luminescent reagent is modifiable by the analyte thereby changing the generation of heat, which change in heat generation is proportional to the concentration of the analyte, a transducer having a pyroelectric or piezoelectric element and electrodes which is capable of transducing the change in heat to an electrical signal, and a detector which is capable of converting the electrical signal into an indication of the concentration of the analyte. The invention also relates to a method for detecting an analyte. | 2012-02-09 |
| 20120034637 | DETECTION OF TRICHOMONAS AND CANDIDA - The invention relates to a method and a kit for the detection of | 2012-02-09 |
| 20120034638 | Electrochemical assay for the detection of enzymatically active PSA - The present invention is directed to the diagnosis of cancer associated with enzymatically active PSA in samples. | 2012-02-09 |
| 20120034639 | ANALYTE DETECTION - The present invention relates to analyte detection test systems, including test systems for the oral detection of analytes in saliva. The present invention also provides compositions and methods for storing multiple assay tests and compositions and methods for measuring the concentration of analytes in a sample. | 2012-02-09 |
| 20120034640 | Isotonic Buffered Composition and Method that Enables Counting of Cells - The present invention discloses multi-purpose metering fluid/rinse reagents for use in automated cellular analyzers that use liquid volumetric metering. The compositions contain a chelating agent, an ionizing salt, optionally a stabilizing ion, a buffer, a non-hemolytic surfactant, and optionally an antimicrobial agent. Advantageously, the compositions produce less than one part-per-million of formaldehyde over the course of one year. Methods for using the compositions are also described. | 2012-02-09 |
| 20120034641 | BIOLOGICAL INFORMATION ACQUISITION METHOD - A biological information acquisition method includes: measuring an amount of nicotinamide metabolite in a sample collectable from a living organism in a minimally invasive manner; and acquiring information concerning the living organism based on the measured amount of nicotinamide metabolite. | 2012-02-09 |
| 20120034642 | METHOD FOR OBTAINING A SINGULAR CELL MODEL CAPABLE OF REPRODUCING IN VITRO THE METABOLIC IDIOSYNCRASY OF HUMANS - The method is based on the use of expression vectors coding for the sense and anti-sense mRNA of the Phase I and Phase II drug biotransformation enzymes showing a greatest variability in humans for transforming cells expressing reductase activity. Such vectors can modulate (increase or decrease) the individualized expression of an enzyme without affecting the other enzymes. This singular cell model can reproduce in vitro the metabolic idiosyncrasy of humans. It is applicable in the study of development of new drugs, specifically in the study of metabolism, potential idiosyncratic hepatotoxicity, medicament interactions, etc., of new drugs. | 2012-02-09 |
| 20120034643 | FLUORESCENT PROTEIN - An object of the present invention is to provide a red or orange fluorescent protein, which is characterized in that the difference (stokes shift) between an excitation peak value (wavelength of maximum absorption) and a fluorescence peak value (wavelength of maximum fluorescence) is greatened, so that the maximum fluorescence can be obtained by the maximum excitation. The present invention provides a novel fluorescent protein monomerized by introducing a mutation into a florescent protein derived from | 2012-02-09 |
| 20120034644 | IDENTIFYING MATERIAL FROM A BREAST DUCT - Methods and systems for identifying material from a breast duct using one or more markers that can be identified in ductal fluid retrieved from the breast are provided. | 2012-02-09 |
| 20120034645 | METHOD AND APPARATUSES FOR CONDUCTING ASSAYS - Disclosed are methods for conducting assays of samples, such as whole blood, that may contain cells or other particulate matter. Also disclosed are systems, devices, equipment, kits and reagents for use in such methods. One advantage of certain disclosed methods and systems is the ability to rapidly measure the concentration of an analyte of interest in blood plasma from a whole blood sample without blood separation and hematocrit correction. | 2012-02-09 |
| 20120034646 | DETECTION OF H. PYLORI UTILIZING UNLABELED UREA - Disclosed is a method and device for detection of | 2012-02-09 |
| 20120034647 | METHOD AND APPARATUS FOR AUTOMATED WHOLE BLOOD SAMPLE ANALYSES FROM MICROSCOPY IMAGES - A method and apparatus for identifying one or more target constituents (e.g., white blood cells) within a biological sample is provided. The method includes the steps of: a) adding at least one colorant to the sample; b) disposing the sample into a chamber defined by at least one transparent panel; c) creating at least one image of the sample quiescently residing within the chamber; d) identifying target constituents within the sample image; e) quantitatively analyzing at least some of the identified target constituents within the image relative to one or more predetermined quantitatively determinable features; and f) identifying at least one type of target constituent within the identified target constituents using the quantitatively determinable features. | 2012-02-09 |
| 20120034648 | PENTOSE SUGAR FERMENTING CELL - The invention relates to a cell which comprises a nucleotide sequence encoding a xylose isomerase, wherein the amino acid sequence of the xylose isomerase has at least about 70% sequence identity to the amino acid sequence set out in SEQ ID NO: 3 and wherein the nucleotide sequence is heterologous to the host. A cell of the invention may be used in a process for producing a fermentation product, such as ethanol. Such a process may comprise fermenting a medium containing a source of xylose with a cell of the invention such that the cell ferments xylose to the fermentation product. | 2012-02-09 |
| 20120034649 | MICROORGANISM AND METHOD FOR PRODUCING CANTHAXANTHIN - A carotenoid producing bacterium belonging to the genus | 2012-02-09 |
| 20120034650 | Nucleic acid molecule of a biosynthetic cluster encoding non ribosomal peptide synthases and uses thereof - The present invention relates to the provision of a polynucleotide comprising one or more functional fragments of a biosynthetic gene cluster involved in the production of a compound of formula (I) or (I′). The present invention also provides a method of preparing a compound of formula (I) or (I′) or of formula (II) to (VII), (XI) to (XIV) and (XVII) and (XVIII). Moreover, the use of such compound as a pharmaceutical composition is also provided in the present invention. | 2012-02-09 |
| 20120034651 | Akt activity specifically inhibiting polypeptide - The present invention is to provide a polypeptide specifically inhibiting the activity of Akt (Protein Kinase B), the DNA thereof, the antibody thereof, an inhibitor of Akt activity or an antitumor agent, and the like. The polypeptide comprises polypeptides (SEQ ID NO: 1, 3, 5, 7, and 9 of the sequence listing) that contain an amino acid sequence corresponding to any of the position of amino acid residue 10-24 of human TCL1, amino acid residue 8-22 of human TCL1B, amino acid residue 5-19 of human MTCP1, and amino acid residue 9-24 of mouse or rat TCL1; and the derivatives. Further, the present invention includes DNA encording the polypeptide (SEQ ID NO: 2, 4, 6, 8 or 10 of the sequence listing), and the antibodies specifically binding to the polypeptides. The polypeptide of the present invention can be used for an inhibitor of Akt activity, an antitumor agent, or the like. | 2012-02-09 |
| 20120034652 | Method for the Targeted Integration of Multiple Copies of a Gene of Interest in a Yarrowia Strain - This invention concerns a method for the targeted integration of at least three copies of a gene of interest in the genome of a | 2012-02-09 |
| 20120034653 | Trophic Conversion of Obligate Phototrophic Algae Through Metabolic Engineering - Most microalgae are obligate photoautotrophs and their growth is strictly dependent on the generation of photosynthetically-derived energy. In this study it is shown that the microalga | 2012-02-09 |
| 20120034654 | METHOD FOR TRANSFORMING SCHIZOSACCHAROMYCES POMBE, TRANSFORMANT OF SCHIZOSACCHAROMYCES POMBE AND METHOD FOR PRODUCING HETEROLOGOUS PROTEIN - To provide a method for transforming | 2012-02-09 |
| 20120034655 | FSH PRODUCING CELL CLONE - The present invention relates to nucleic acid molecules comprising a nucleic acid sequence coding for the α- and the β-chain of the human follicle stimulating hormone (FSH), respectively, which has been modified with respect to the codon usage in CHO cells. The present invention further relates to a recombinant nucleic acid molecule comprising such nucleic acid sequences and host cells containing such recombinant nucleic acid molecules, as well as their use in the production of recombinant human FSH. Finally, the present invention also relates to a method for producing host cells expressing human follicle stimulating hormone by transfecting cells in suspension culture under serum-free conditions with the recombinant nucleic acid molecule of the present invention. | 2012-02-09 |
| 20120034656 | Neutralising Antibody Molecules Having Specificity for Human IL-17 - The invention relates to an antibody molecule having specificity for antigenic determinants of IL-17, therapeutic uses of the antibody molecule and methods for producing said antibody molecule. | 2012-02-09 |
