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06th week of 2012 patent applcation highlights part 35
Patent application numberTitlePublished
20120034256HCV VACCINES AND METHODS FOR USING THE SAME - Improved anti-HCV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus HCV genotype 1 a/1 b NS3 and NS4A. Pharmaceutical composition, recombinant vaccines comprising and live attenuated vaccines are disclosed as well methods of inducing an immune response in an individual against HCV are disclosed.2012-02-09
20120034257METHYLATED HEPARIN-BINDING HEMAGGLUTININ RECOMBINANT MYCOBACTERIAL ANTIGEN, PREPARATION METHOD AND IMMUNOGENIC COMPOSITIONS COMPRISING SAME - The invention concerns a methylated immunogenic recombinant peptide sequence comprising mycobacterial heparin-binding hemagglutinin. The invention also concerns chemical and enzymatic methods for preparing such a sequence, the sequence being previously produced in a non-methylated recombinant form then methylated by post-translational modification. The invention further concerns recombinant tools, vectors and host cells for implementing post-translational enzymatic methylation of the recombinant HBHA. The invention finally concerns immunogenic compositions comprising methylated, native or recombinant HBHA, such compositions being useful for preparing vaccines against mycobacterial infections.2012-02-09
20120034258POLYPEPTIDES AND IMMUNIZING COMPOUNDS CONTAINING GRAM POSITIVE POLYPEPTIDES AND METHODS OF USE - The present invention provides isolated polypeptides isolatable from a 2012-02-09
20120034259ANTIGEN DELIVERY VECTORS AND CONSTRUCTS - The present invention relates to fluorocarbon vectors for the delivery of antigens to immunoresponsive target cells. It further relates to fluorocarbon vector-antigen constructs and the use of such vectors associated with antigens as vaccines and immunotherapeutics in animals.2012-02-09
20120034260Elastase inhibitor - An elastase inhibitor that contains as active ingredients thereof raspberry extract and hydroxyproline, and optionally further contains yeast extract.2012-02-09
20120034261NOVEL IMMUNOGENIC COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF MENINGOCOCCAL DISEASE - The present invention relates to 2012-02-09
20120034262Bovine Herpes Virus-1 Compositions, Vaccines and Methods - The disclosure relates generally to the treatment or prevention of disease in cattle. More particularly, the invention is directed to the production and use of modified bovine herpesvirus 1 (BHV-1) and their use in compositions and vaccines that protect cattle from BHV-1 infection while not suppressing the immunological response in the host. In one example, the invention is directed to the use of modified BHV-1, administered with additional immunogens, either through co-administration and/or through administration in combination vaccines, and the use of these vaccines for the protection of cattle from disease. In one example, use of the modified BHV-1 in the administered compositions facilitates an immune response to or against the additional immunogens.2012-02-09
20120034263SEQUENCES DIAGNOSTIC FOR SHRIMP PATHOGENS - Primers have been isolated that are diagnostic for the detection of the white spot syndrome virus (WSSV). The primers are based on a new portion of the WSSV genome and may be used in primer directed amplification or nucleic acid hybridization assay methods.2012-02-09
20120034264INFLUENZA HEMAGGLUTININ AND NEURAMINIDASE VARIANTS - Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided.2012-02-09
20120034265INFLUENZA HEMAGGLUTININ AND NEURAMINIDASE VARIANTS - Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.2012-02-09
20120034266METHODS AND COMPOSITIONS FOR IMPROVING IMMUNE RESPONSE BY A NUTRACEUTICAL ANTIOXIDANT - The present invention provides a new means of restoring the immune system in aging and immunocompromised individuals using an antioxidant nutraceutical. The nutraceutical stimulates the aging immune system through the Nrf2 master gene regulatory pathway. The invention is based in part on the discovery that the Nrf2 has antioxidant and immune restorative activity. The nutraceutical improves function of both the innate and adaptive immune systems.2012-02-09
20120034267INACTIVATED VARICELLA ZOSTER VIRUS VACCINES, METHODS OF PRODUCTION, AND USES THEREOF - The invention provides an inactivated varicella zoster virus (VZV), and compositions and vaccines comprising said inactivated VZV, wherein the infectivity of the VZV is undetectable and wherein the inactivated VZV induces an immune response against VZV when administered to a patient. In embodiments of the compositions described herein, the VZV is inactivated with gamma radiation. The invention also provides a method of preparing an inactivated VZV vaccine, the method comprising gamma irradiating a sample comprising a VZV using from about 5 kGy to about 50 kGy of gamma radiation. Also provided by the invention herein is a method of treatment of or immunization against HZ or other disease associated with the reactivation of VZV, the method comprising administering to a subject a vaccine or pharmaceutical composition comprising a therapeutically effective amount of an inactivated VZV and a pharmaceutically acceptable carrier, wherein the VZV is inactivated by gamma irradiation.2012-02-09
20120034268BACTERIAL GHOSTS FOR MEDIATING INNATE IMMUNITY - The invention relates to the use of bacterial ghosts (BG) to promote an innate immune response.2012-02-09
20120034269ANALOGS OF ALPHA GALACTOSYLCERAMIDE AND USES THEREOF - Compounds of formula2012-02-09
20120034270S1P Receptors Modulators - The invention relates to novel compounds that have S1P receptor modulating activity and, preferably, apoptotic activity and/or anti proliferative activity against cancer cells and other cell types. Further, the invention relates to a pharmaceutical comprising at least one compound of the invention for the treatment of diseases and/or conditions caused by or associated with in-appropriate S1P receptor modulating activity or expression, for example, cancer. A further aspect of the invention relates to the use of a pharmaceutical comprising at least one compound of the invention for the manufacture of a medicament for the treatment of diseases and/or conditions caused by or associated with inappropriate S1P receptor modulating activity or expression such as cancer.2012-02-09
20120034271INJECTABLE IN-SITU CROSSLINKED HYDROGEL AND METHODS OF MAKING AND USING THEREOF - The present invention discloses an injectable in-situ crosslinked hydrogel and its preparation method. The preparation method is as below: Filling the crosslinking active solution of at least one kind of the biocompatible macromolecules containing more than two thiol groups on the side chains into an injectable container and sealing it, and forming the in-situ disulfide-bond crosslinked hydrogel under the action of the dissolved oxygen; through controlling such parameters as partial pressure of oxygen gas, temperature and time, regulating concentration of the oxygen dissolved in the crosslinking active solution, and optimizing the gelation process and the gel properties. The present invention further relates to application of the injectable in-situ crosslinked hydrogel in pharmaceutics or surgery. The present invention has many advantages, such as no need for a crosslinking agent, simple preparation process, convenient application, containing no impurities, good biocompatibility, no toxic and side effect, and wide application in the medical science.2012-02-09
20120034272Pharmaceutical dosage form comprising nifedipine or nisoldipine and an angiotensin II antagonist and/or a diuretic - The present invention relates to a pharmaceutical dosage form comprising an active ingredient combination of nifedipine or nisoldipine and at least one angiotensin II antagonist and/or at least one diuretic, characterized in that nifedipine or nisoldipine is released in the body in a controlled (modified) manner and the angiotensin II antagonist and/or the diuretic is released rapidly (immediate release (IR)), and also to processes for their preparation, to their use as medicaments and to their use for the prophylaxis, secondary prophylaxis or treatment of disorders.2012-02-09
20120034273EXTRUDATE HAVING SPICULAR ACTIVE SUBSTANCES - The invention relates to extrudates containing at least one pharmaceutically active substance in the form of needles, wherein the ratio of the particle size of the needle-shaped pharmaceutically active substance to the strand diameter is at least 1:15, and the use of these extrudates for the production of medicaments.2012-02-09
20120034274PHARMACEUTICAL COMPOSITION COMPRISING ONE OR MORE FUMARIC ACID ESTERS - A pharmaceutical controlled release composition comprising one or more fumaric acid esters.2012-02-09
20120034275POWDER FORMULATIONS FOR INHALATION, COMPRISING ENANTIOMERICALLY PURE BETA AGONISTS - The present invention relates to powder formulations for inhalation containing enantiomerically pure compounds of general formula 12012-02-09
20120034276SOLID PREPARATION - A solid preparation 2012-02-09
20120034277RESUSCITATION FLUID - A method for treating conditions related to lack of blood supply with a lipid based resuscitation fluid is disclosed. The resuscitation fluid contains a lipid component and an aqueous carrier. The lipid component forms an emulsion with the aqueous carrier. The resuscitation fluid can be used to increase the blood pressure and to carry oxygen to tissues. The resuscitation fluid can also be used for preserving the biological integrity of donor organs for transplantation.2012-02-09
20120034278OPHTHALMIC PREPARATION CONTAINING MENTHYL ESTER OF INDOMETHACIN - There is provided an ophthalmic pharmaceutical preparation comprising menthyl ester of indomethacin as an active ingredient. Also provided are different possible formulations of the ophthalmic preparation, and different methods of treating ophthalmic irritation using the ophthalmic preparation.2012-02-09
20120034279TRANSSCLERAL DELIVERY - Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration.2012-02-09
20120034280ORAL COMPOSITIONS COMPRISING A ZINC COMPOUND AND AN ANTI-MICROBIAL AGENT - Oral compositions and methods of use thereof are provided herein. The oral compositions comprise a first component comprising at least one E2012-02-09
20120034281Solid Powder Cosmetic And Method For Producing The Same - An object of the present invention is to provide a solid powder cosmetic having an excellent long-lasting makeup effect and the feeling of use. A solid powder cosmetic comprising: spherical poly(meth)acrylate particles having pores in the interiors and at the surfaces and having an average particle size of 3 to 20 μm, a specific surface area of 80 to 180 m2012-02-09
20120034282DENTIFRICE COMPOSITION AND METHOD OF USE - An exfoliating dentifrice composition is described that contains a plurality of granules and an orally acceptable vehicle. The granules include at least one polymeric binding agent. The composition includes at least one abrasive agent having an average particle diameter of 0.01 mm to 4 mm. Also included are methods of exfoliating an oral cavity soft tissue by use of the composition.2012-02-09
20120034283GRANULAR WASHING, CLEANING OR TREATMENT AGENT ADDITIVE - A granular washing, cleaning or treatment agent additive, comprising 5 to 90 wt % of a particulate carrier material having an oil absorption capacity of at least 100 ml/100 g and 10 to 80 wt % of capsules in which one or more beneficial agents are enclosed, can be produced in that the particulate carrier material is fluidized, a pourable capsule preparation is applied to the carrier material, and the mixture thus obtained is granulated.2012-02-09
20120034284Microencapsulation Product and Process - Microcapsules possessing Lewis acid-Lewis base salt walls incorporate water-immiscible materials, such as N,N-di-ethyl-m-toluamide (DEET), as a core component. Such microcapsules, or similar microcapsules incorporating other core components, may be made by emulsifying a water-immiscible core component in an aqueous solution of one wall-forming reactant, such as the Lewis base, and then mixing that solution with the other wall-forming reactant, such as the Lewis acid. Various adjuvants may be included with the core component to contribute additional characteristics, such as enhancement of a controlled release characteristic or improved mechanical stability.2012-02-09
20120034285Mosquito Net with Dinotefuran and PBO for Killing Mosquitoes, Especially Mosquitoes with Pyrethroid Resistance - Dinotefuran and PBO is used for killing mosquitoes, as PBO increases the knockdown speed of Dinotefuran.2012-02-09
20120034286STABILIZATION OF BIOSOLIDS USING IRON NANOPARTICLES - This invention discloses a stabilized biosolids composition and a method for the stabilization of biosolids. It entails the use of a chemically and biologically reactive material, in the form of ultrafine iron particles. The nanometer-sized iron particles are capable of degrading odorous organosulfur compounds, transforming persistent and toxic organic pollutants such as PCBs and chlorinated pesticides, inhibiting the growth of pathogens by increasing pH and maintaining the increased pH of the stabilized biosolids, immobilizing toxic metal ions such as mercury and lead, and improving the overall quality of biosolids for land application and plant growth.2012-02-09
20120034287Quaternary Ammonium Glycol Ether Disinfectant Wipes - A nonwoven absorbent wipe is impregnated with an antibacterial and antimicrobial composition comprising quaternary ammonium salts, glycol ethers, a surfactant and water. A method of preparation and a process for disinfecting hard surfaces with the wipe are provided.2012-02-09
20120034288COMPOSITIONS AND METHODS FOR ENHANCED ATTRACTION OF NOCTUID MOTHS - The invention provides compositions for attracting noctuid moths, which include at least one pheromone and at least one enhancer. The enhancer is a naturally-occurring phytochemical compound. The enhancer is preferably trans-2, cis-6-nonadienal. The invention also provides lures and traps containing the composition for attracting noctuid moths, and methods for attracting, capturing, killing or sterilizing noctuid moths using the composition.2012-02-09
20120034289Antimicrobial Material - The invention relates to a method for preparing antimicrobial material. The method comprises heating material comprising wood or bark or material derived therefrom, under conditions sufficient to render the material antimicrobial. The invention also relates to antimicrobial materials prepared by such methods, and to various uses of the antimicrobial materials, for example in reducing microbial activity in animal bedding, such as that which is used in poultry farming.2012-02-09
20120034290QUATERNARY AMMONIUM SALTS AS MICROBE INHIBITORS - The present invention relates to quaternary ammonium salts and their use as mold inhibitors. The quaternary salts can be prepared by a chloride ion-promoted reaction between a tertiary amine and an alcohol or polyol in strong acid solution. The quaternary ammonium salts can be applied to a substrate in order to impart anti-mold properties to the substrate. Preferably, the quaternary ammonium salt compounds are applied to paper substrates in an amount of about 1000 ppm. Preferably, the quaternary ammonium salts compounds are applied as mixtures of more than one quaternary ammonium salt compound. The treated substrate does not require encapsulators, binders, or retention aids.2012-02-09
20120034291NANOIMPRINTING OF SILK FIBROIN STRUCTURES FOR BIOMEDICAL AND BIOPHOTONIC APPLICATIONS - The present invention provides for photonic nanoimprinted silk fibroin-based materials and methods for making same, comprising embossing silk fibroin-based films with photonic nanometer scale patterns. In addition, the invention provides for processes by which the silk fibroin-based films can be nanoimprinted at room temperature, by locally decreasing the glass sition temperature of the silk film Such nanoimprinting process increases high throughput and improves potential for incorporation of silk-based photonics into biomedical and other optical devices.2012-02-09
20120034292Composition For Transdermal Delivery Of Fentanyl - A transdermal drug delivery composition comprises an acrylate copolymer and from about 8% to about 30% by weight fentanyl. A transdermal fentanyl delivery composition comprising methyl laurate or tetraglycol as a permeation enhancer is also provided. The transdermal drug delivery compositions can be used to make a transdermal drug delivery device for the delivery of fentanyl.2012-02-09
20120034293TRANSDERMAL DELIVERY OF CANNABINOIDS - The present invention overcomes the problems associated with existing drug delivery systems by delivering cannabinoids transdermally. Preferably, the cannabinoids are delivered via an occlusive body (i.e., a patch) to alleviate harmful side effects and avoid gastrointestinal (first-pass) metabolism of the drug by the patient. A first aspect of the invention provides a method for relieving symptoms associated with illness or associated with the treatment of illness in a mammalian subject, comprising the steps of selecting at least one cannabinoid from the group consisting of cannabinol, cannabidiol, nabilone, levonantradol, (−)-HU-210, (+)-HU-210, 11-hydroxy-Δ2012-02-09
20120034294METHOD OF MAKING SMALL LIPOSOMES - Liposomes of constrained particle size are prepared by substantially continuously mixing substantially continuously flowing streams of water, and of an organic solvent contain lipid(s) capable of forming liposomes, and cooling the mixture so liposomes form, the ratio of the flow rate of the stream of water to the flow rate of the stream of organic solvent, and the rate of cooling of said mixture, being controlled so as to obtain a preparation of liposomes such that at least about 90% of the liposomes are of a particle size less than about 200 nm.2012-02-09
20120034295CHIMERIC SMALL MOLECULES FOR THE RECRUITMENT OF ANTIBODIES TO CANCER CELLS - The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.2012-02-09
20120034296PROLONGED DURATION LOCAL ANESTHESIA WITH MINIMAL TOXICITY - Compositions containing site 1 sodium channel blockers for use as local anesthetics with rapid nerve block, improved potency and efficacy, and no local toxicity have been developed. Liposomes were employed for increased loading of the site 1 sodium channel blocker, producing prolonged duration of block without systemic toxicity. In one embodiment, the compositions contain a site 1 sodium channel blocker alone. In another embodiment, the compositions contain a site 1 sodium channel blocker in combination with a corticosteroid. As demonstrated by the examples, encapsulating site 1 sodium channel blockers in liposomes results in rapid and prolonged nerve block without systemic toxicity, which is enhanced by the addition of a corticosteroid. Fluid liposomes showed more rapid release of STX than did solid ones, and dexamethasone accelerated STX release.2012-02-09
20120034297Pharmaceutical dosage forms comprising 6'-fluoro-(N-methyl- or N,N-dimethyl-)-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3- ,4,b]indol]-4-amine - A pharmaceutical dosage form for administration twice daily, once daily or less frequently, which contains 6′-fluoro-(N-methyl- or N,N-dimethyl)-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine or a physiologically acceptable salt thereof.2012-02-09
20120034298Chewable Soft Capsule - A matrix formulation for a soft chewable capsule is provided which includes a gel-forming composition, a plasticizer, a polymer modifier, and water. The polymer modifier may be a carboxylic acid or other organic compound that alters the physical and/or chemical properties of the capsule formulation. A chewable soft capsule is also provided, having enhanced organo-leptic and processing properties. An active material may be delivered to a user using this dosage form. A method of forming the chewable soft capsule is also provided.2012-02-09
20120034299COMPOSITIONS FOR THE TREATMENT OF GLUTEN INTOLERANCE AND USES THEREOF - The present invention provides compositions for use in the prophylaxis or treatment of a condition arising from gluten intolerance, the compositions including at least partially purified caricain (or a biologically active fragment, analogue or variant thereof) alone or in combination with other suitable enzymes including bromelain, and/or an intestinal extract, as herein described. The present invention also provides methods of using such compositions for the prophylaxis or treatment of a condition arising from gluten intolerance.2012-02-09
20120034300STABILIZED ZOLPIDEM PHARMACEUTICAL COMPOSITIONS - Methods of inducing antinociception in a human are described. The method includes the step of administering an effective dose of a polypeptide comprising L-neo-tryptophan to the human extracranially. The polypeptide containing L-neo-tryptophan could be, but is not limited to, NT64L, NT65L, NT66L, NT67L, NT69L, NT69L′, NT71, NT72, NT73, NT74, NT75, NT76, or NT77.2012-02-09
20120034301TABLET AND PESTLE THEREFOR - A tablet which comprises solid particles, especially magnesium oxide particles as the main component and has excellent shape retentivity with extremely low susceptibility to wearing and chipping. The tablet has a domed shape on each of the upper and lower horizontal surfaces of a cylindrical plate shape, wherein the domed shape on each of the upper and lower horizontal surfaces satisfies the following requirements (a), (b) and (c) in the cross-sectional shape including the center line of the cylindrical plate shape: (a) each corner has an angle of 25 to 45°, (b) each corner has a horizontal length of 0.30 to 1.0 mm, and (c) the cup has a depth of 0.6 to 1.2 mm.2012-02-09
20120034302PARTICULATE COMPOSITION AND THE METHOD OF MAKING THE SAME - A particulate material for delivering an active ingredient and a method for making the same is provided. The particulate material can be included in a solid dosage form to provide both high tablet strength and smooth-dissolving mouth-feel. The particulate material includes at least two low moldability sugars, such as, dextrose and sucrose, in an amount of from about 70% to about 100% of the particulate material and is granulated in the presence of a binding agent.2012-02-09
20120034303PHARMACEUTICAL FORMULATION COMPRISING ONE OR MORE FUMARIC ACID ESTERS IN AN EROSION MATRIX - A pharmaceutical formulation comprising an erosion matrix comprising one or more fumaric acid esters as well as one or more rate-controlling agents, wherein erosion of said erosion matrix permits controlled release of said fumaric acid ester(s).2012-02-09
20120034304Prolonged Release Pharmaceutical Composition Containing 3-(3-Dimethylamino-1-Ethyl-2-Methyl-Propyl)Phenol - A pharmaceutical formulation for prolonged release of the active ingredient 3-(3-dimethylamino-1-ethyl-2-methylpropyl)phenol or a pharmaceutically acceptable salt thereof in a matrix containing between 1 and 80 wt. % of at least one pharmaceutically acceptable hydrophilic or hydrophobic polymer as a matrix forming agent and exhibiting in vivo the following release rate: 3 to 35% by weight (based on 100% by weight active ingredient) 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 0.5 hours; 5 to 50% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 1 hour; 10 to 75% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 2 hours; 15 to 82% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 3 hours; 30 to 97% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 6 hours; more than 50% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 12 hours; more than 70% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 18 hours, and more than 80% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 24 hours.2012-02-09
20120034305SOLID DISPERSING VACCINE COMPOSITION FOR ORAL DELIVERY - The invention disclosed herein relate to an oral vaccine in which the vaccine composition and adjuvant(s) are carried on a solid fast-dispersing dosage form. The vaccines are targeted toward mucosal tissue and the adjuvant serves to ensure sufficient residence time for the vaccine composition on the mucosal tissue to facilitate its absorption thereby. The fast-dispersing oral solid vaccine dosage form of the invention is particularly useful to administer the vaccine to patients that have difficulty swallowing medications. In one embodiment, the invention provides a fast disintegrating oral solid vaccine dosage form comprising: an immunogenic amount of an antigenic preparation, the antigenic preparation comprising a microsphere-antigen complex; an adjuvant, wherein the adjuvant enhances the absorption of the antigen or potentiates the immunogenic response; a mucoadhesive substance; and a low density dosage form matrix.2012-02-09
20120034306POLYMERIC DRUG DELIVERY SYSTEMS AND PROCESSES FOR PRODUCING SUCH SYSTEMS - The subject invention relates to implants for delivery of therapeutic agents such as opioids, and the manufacture and uses of such implants.2012-02-09
20120034307Aqueous gel formulation and method for inducing topical anesthesia - Disclosed is a stable aqueous gel formulation suitable for topical use comprising water, an anesthetic (e.g., lidocaine hydrochloride), a viscoelastic polymer, and a tonicity modifier, wherein the aqueous gel formulation is free of preservatives and phosphate buffer, is isotonic with physiological fluids, and is sterile and has low particulate count. Also disclosed is a method of inducing topical anesthesia on a tissue or organ, e.g., the eye, of an animal comprising providing a stable aqueous gel formulation comprising water, an anesthetic, a viscoelastic polymer, and a tonicity modifier, wherein the aqueous gel formulation is free of preservatives and phosphate buffer, is isotonic with physiological fluids, and is sterile, and topically administering an effective amount of the aqueous gel formulation to the tissue or organ of the animal.2012-02-09
20120034308REDUCED-CHOLESTEROL DAIRY PRODUCT FOR USE AS A MEDICAMENT - A ruminant reduced-cholesterol dairy product is used as a medicament.2012-02-09
20120034309HONEY PRODUCT HAVING A LOW WATER CONTENT - The present application relates to a honey product having a low water content. The honey product retains the physical and palatable properties of untreated honey while having a prolonged shelf-life. It can be advantageously used to sweeten beverages (such as hot beverages) and in the manufacture of throat lozenges and/or confectionery.2012-02-09
20120034310NUTRACEUTICAL FOR THE PREVENTION AND TREATMENT OF CANCERS AND DISEASES AFFECTING THE LIVER - A composition comprising vegetable/herbal based dietary ingredients, or extracts, which contains vitamins and nutrients that provide a novel nontoxic treatment for liver cancers, hepatitis, and liver cirrhosis. The composition can be taken as a daily dietary supplement to enhance normal physiological functions of the body. The said composition, or extracts thereof, are useful and effective in the treatment and prevention of liver and possibly other cancers. The compositions are also useful for administration to patients with pre-existing hepatitis and/or liver cirrhosis. The compositions or extracts thereof may be useful for treating other cancers and other disorders, diseases, or conditions.2012-02-09
201200343124-ISOPROPYL-3-METHYLPHENOL FOR THE TREATMENT OF INFLAMMATION - This invention relates to the use of 4-isopropyl-3-methylphenol (IPMP) for combating inflammation and compositions comprising IPMP for such use.2012-02-09
20120034313Microbiocide/Sulfide Control Blends - A chemical blend that simultaneously kills bacteria and suppresses the production of hydrogen sulfide (H2012-02-09
20120034314Antiseptic Liquid Formulation, A Method for Its Use, and A Method for Preparing the Formulation - An antiseptic formulation capable of providing antimicrobial properties over an extended period of time is disclosed. The formulation includes chelated metal ions and a fixative polymer with the capacity to bond the chelated metal ions to the skin. This fixative polymer, polyquaternium-69 has the ability to bond chelated metal ions, and other types of antimicrobial agents, to the skin for periods of hours or days depending on the conditions in which it is used. An antiseptic liquid formulation can be integrated in a soap product and a spray product. An antiseptic gel formulation is further disclosed.2012-02-09
20120034315SOLID FORMS OF AN AZOCYCLIC AMIDE - Disclosed are solid forms of 1-[4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]-1-piperidinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone (Compound 1). Methods for the preparation of solid forms of Compound 1 and for the conversion of one solid form of Compound 1 into another are disclosed.2012-02-09
20120034316PHARMACEUTICAL COMPOSITIONS FOR DEHYDRATING, ATROPHYING AND ELIMINATING PATHOLOGICAL TISSUES - The present invention provides a pharmaceutical composition for dehydrating, atrophying and eliminating pathological tissues comprising inorganic polymeric ferric salt and/or inorganic polymeric ferric salt composite as its active ingredients, in which the inorganic polymeric ferric salt is polyferric sulfate, and the inorganic polymeric ferric salt composite is selected from a group consisting of poly-silicate ferric salts, polyphosphate ferric salts and their analogue. A surprising medical effect can be reached by treating pathological tissues with the pharmaceutical composition of the present invention which will make the treated pathological tissues dehydrated, atrophied, and absorbed or sloughed off. The pharmaceutical composition of the present invention is cost-effective, convenient to use and has significant effects in treatment of hemorrhoids, hemangiomas, varix, hygromas, abscess, tumors, scalding and burning wounds, bleeding traumatic wounds, and/or local injuries caused by chemical agents or microorganism.2012-02-09
20120034317Prediction of Response to Platinum-Based Therapy - Method for determining whether a mammalian subject having a cancer belongs to a first or a second group, wherein subjects of the first group are more likely to respond to a platinum-based therapy than subjects of the second group, comprising the steps of: evaluating the amount of RBM3 protein or RBM3 mRNA present in at least part of a sample earlier obtained from said subject, and determining a sample value corresponding to said amount; comparing the sample value with a reference value; and, if said sample value is higher than said reference value, concluding that said subject belongs to a first group; and if said sample value is lower than or equal to said reference value, concluding that said subject belongs to a second group. There is further provided means useful in the establishment of a treatment prediction.2012-02-09
20120034318DIAGNOSTIC METHOD USING PALB2 - The present invention provides a method for detecting mutations in the PALB2 gene in pancreatic cancer patients and in individuals having a family history of pancreatic cancer. Methods are also provided for diagnosing a predisposition to pancreatic cancer, for predicting a patient's response to pancreatic cancer therapies, and for treating pancreatic cancer, based on presence of a PALB2 mutation or abberant PALB2 gene expression in a patient.2012-02-09
20120034319ANTIMICROBIAL HYDROCHLORIC ACID CATHETER LOCK SOLUTION AND METHOD OF USE - A catheter lock solution includes a hydrochloric acid solution having a concentration of 0.3 Molar to 1.0 Molar. This hydrochloric acid solution may be used to lock a catheter and/or salvage an infected catheter.2012-02-09
20120034320Skin Penetration Composition - The present invention comprises an all-natural composition of matter and methods of delivering nutrients, medicines, pain relievers, antioxidants, antidotes, antibiotics and various active ingredients and supplements directly to the affected area of the body. The all-natural carrier composition consists essentially of the combination of a natural oil, water, salt(s), natural emulsifier, natural sugar(s), plant extracts, natural acid(s), starch and natural flavor(s). The active substances that are mixed with the all-natural carrier composition, include, but are not limited to, drugs, vitamins, minerals, antibiotics anti fungal agents, antioxidants, diuretics, allergy medicines, anti-inflammatory agents, muscle relaxers, pain reducers, diabetic drugs, neuropathy drugs, chemotherapy agents, arthritis drugs, lotions for eczema, shingles, psoriasis, skin rash; herbal medicines, erectile dysfunction drugs, hormones, cholesterol drugs, essential fatty acids, and the like. The all-natural carrier composition facilitates the penetration of active substances into the dermal layer of the skin.2012-02-09
20120034321NITRIC OXIDE ENHANCING PROSTAGLANDIN COMPOUNDS, COMPOSITIONS AND METHODS OF USE - The invention provides methods for treating ophthalmic disorders comprising at least one nitric oxide enhancing prostaglandin compound or a pharmaceutically acceptable salt thereof, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The nitric oxide enhancing prostaglandin compounds comprise at least one heterocyclic nitric oxide donor group and/or at least one nitroxide group.2012-02-09
20120034322INTESTINAL BACTERIAL FLORA DISTRIBUTION RATIO REGULATOR - A food or pharmaceutical capable of regulating an intestinal bacterial flora distribution ratio, which is safe and has few side effects, is provided.2012-02-09
20120034323COMPOSITIONS AND METHODS FOR PROMOTING WEIGHT LOSS AND INCREASING ENERGY - The present invention relates to compositions comprising plants and extracts of plants with chlorogenic acids and antioxidants and/or caffeine; methods for preparing the same; and methods to promote weight loss through the administration of compositions containing these plants and plant extracts in specific proportions.2012-02-09
20120034324ROLE OF AN HERBAL FORMULATION IN THE PREVENTION AND MANAGEMENT OF AGE RELATED NEURODEGENERATIVE DISORDERS WITH SPECIAL REFERENCE TO SENILE DEMENTIA - According to this invention there is provided a herbal formulation for the prevention and management of neurodegenerative disorders comprising, hydro-methanolic extract of at least one plant selected from 2012-02-09
20120034325Formulation for Prevention and Treatment of Bacterial Infections and Preparation Thereof - The invention provides a formulation for the prevention and treatment of bacterial infections by administering an effective amount of the formulation comprising an extract of at least one plant selected from 2012-02-09
20120034326NOVEL HERBAL FORMULATION ADVOCATED FOR THE PREVENTION AND MANAGEMENT OF CORONARY HEART DISEASE - According to this invention there a novel herbal formulation for the prevention and management of coronary heart disease and associated CHD risk factors, comprising, preparing a hydromethanolic extract of at least two plants selected from of 2012-02-09
20120034327APPARATUS FOR COMPRESSION MOULDING PREFORMS - An apparatus for compression-moulding preforms from a dose of plastics comprises a punch arrangement, a die arrangement provided with a cavity and at least two die elements which are mutually movable between a contact position and a detached position. The punch arrangement comprising a punch suitable for being inserted into the cavity and a pressing sleeve mounted slidably around the punch to maintain the at least two die elements in the contact position. The punch arrangement further comprises a jacket arrangement arranged for receiving the punch and the pressing sleeve and at least a first chamber, containing a first fluid at a first pressure and acting on the pressing sleeve, which is entirely bounded by the pressing sleeve and by the jacket arrangement so as to enable the punch to be dismantled from the punch arrangement, maintaining the first chamber pressurised.2012-02-09
20120034328APPARATUS FOR LASER PROCESSING - An apparatus for laser processing a board is provided. The apparatus for laser processing a board includes a chip, a laser, a modulating device and a focus device. The chip receives a first frequency signal to generate a second frequency signal. The laser receives the first frequency signal to emit a first laser beam. The modulating device receives the second frequency signal and the first laser beam, and adjusts the first laser beam to emit a second laser beam. The focus device focuses the second laser beam to emit a third laser beam onto the board for forming plural dots on the board.2012-02-09
20120034329Method of Manufacturing Thermoformed Plastic Articles and Drink Cup Lid Made by Such Method - A method and apparatus for vacuum thermoforming disposable drink cups lids2012-02-09
20120034330INJECTION FOAM MOLDING MACHINE - An injection foam molding machine of the invention includes: a movable mold platen; a fixed mold platen; a mold fastening hydraulic cylinder that is provided at each of four corners of both mold platens; a tie bar that is driven by the hydraulic cylinder to fasten the molds; two sets of mold opening and closing actuators that drive the movable mold platen to move close to or away from the fixed mold platen; two sets of dedicated core back devices; and a control device that controls the two sets of mold opening and closing actuators and the two sets of dedicated core back devices, wherein the control device includes a dedicated core back program that simultaneously controls the two sets of mold opening and closing actuators and the two sets of dedicated core back devices during a foaming core back operation of moving the movable mold platen away from the fixed mold platen.2012-02-09
20120034331Blow Mould Assembly - A blow mould assembly for moulding plastic preforms into plastic containers may include a blow mould unit forming a cavity, within which the plastic preforms can be expanded into plastic containers. The blow mould unit may be of a design that includes at least two parts. The assembly further includes a blow mould holder for receiving the blow mould unit. The blow mould holder may include at least two mould holder elements for receiving parts of the blow mould unit. The assembly further includes a locking mechanism configured to arrest at least one part of the blow mould unit with respect to at least one mould holder element. The locking mechanism includes an engagement member that exerts a force, in a latched condition of the part of the blow mould unit with respect to a mould holder element, onto a section of the part of the blow mould unit. The force holds the part of the blow mould unit relative to the mould holder element. The locking mechanism has an actuating member configured to release a latching engagement between the mould holder element and the part of the blow mould unit. An orientation of the engagement member is latched in a first position of the actuating member and the orientation of the engagement member can be changed in a second position of the actuating member.2012-02-09
20120034332HOT-RUNNER SYSTEM HAVING BLADDER ASSEMBLY - A hot-runner system (2012-02-09
20120034333Injection moulding tool for the manufacture of a hybrid component - Injection moulding tool for the manufacture of a plastic element sheathed with a sheet-metal shell (2012-02-09
20120034334MOLD FOR FORMING OPTICAL FIBER CONNECTOR - A mold for molding optical fiber connector includes a core pin, a cavity mold and a sprue hole defined on the sidewall of the cavity mold. The core pin is used to mold the blind hole of the optical fiber connector. The cavity mold and the core mold cooperatively define a molding cavity for forming the optical fiber connector. A support block is configured in the molding cavity. The molding cavity includes a lens forming portion used to mold the lens and the support block configures a cutout to support the blind hole forming portion to make the blind hole forming portion align with the lens forming portion during the molding process, the opening of the cutout is towards the sprue hole.2012-02-09
20120034335Injection Moulding Method and Apparatus - The invention is directed to a method and an apparatus for the production of three-dimensionally thin products using injection moulding of polymer based material. By dividing one of the mould halves in at least two groups of elements, whereby at least a first group of at least one element forms a rim cavity and a stop, defined as an area of the element contacting the other halve if the mould is in the closed position, and at least a second group of at least one element forms the main body part of the cavity, whereby all the elements together form with the other mould halve one cavity, and whereby each of the groups of elements is connected to its own means for clamping, it is possible to produce a set of different products with a constant rim thickness and a variable thickness of the main body part of the product.2012-02-09
20120034336CHUNKS IN GRAVY FOOD COMPOSITIONS - The invention provides chunks in gravy food compositions comprising chunks in gravy in a chunks to gravy ratio of from about 25:75 to about 60:40, wherein the gravy comprises from about 0.01 to about 1% guar and from about 0.01 to about 1% deacetylated xanthan. The gravy maintains its viscosity during the manufacturing process and ensures an even distribution of the chunks in the chunks in gravy food composition.2012-02-09
20120034337PROTEIN PARTICLES AND THEIR USE IN FOOD - The invention relates to oil-comprising protein particles, oil-free protein particles, and a method for preparation thereof. The invention is also concerned with the use of such protein particles for increasing the protein content of a food product, for replacing fat in a food product, and for controlled release of protein in the gastrointestinal tract.2012-02-09
20120034338Enzyme with silaffin - A method of separating an enzyme construct from a solution, comprising providing an enzyme construct comprising an enzyme fused to a silaffin; adding the enzyme construct to a solution; adding a silica to the solution and separating the silica bound enzyme construct from the solution, wherein the solution is a beverage or a beverage intermediate.2012-02-09
20120034339PROCESS OF MICROBIC BIOTECHNOLOGY FOR COMPLETELY DEGRADING GLUTEN IN FLOURS - The present invention concerns the use of lactic acid bacteria selected and fungal enzymes for the gluten complete degradation from both bread and durum wheat, barley, rye and oat flour. In particular, the invention concerns the use of lactic acid bacteria selected and fungal enzymes for the gluten complete degradation (residual gluten concentration lower than 20 ppm) of cereal flours, which after detoxification can be used according to a standardized biotechnological protocol for the production of various gluten-free foods.2012-02-09
20120034340FOOD COMPOSITION AND RELATED METHODS FOR FRIED GNOCCO - A food composition is described for fried gnocco comprising flour and optionally lard, wherein when the lard is present, the lard quantity is less than 2% of the flour quantity. Methods for preparing fried gnocco are also described. Fried gnocco obtained by frying the described food composition may be softer, more easily digested, more consistent/uniform and non-deformed in appearance, and/or easily prepared.2012-02-09
20120034341Oligo-Saccharide Enhanced Oat-Based Drink for Treating Hyperlipidaemia and Hyperglycemia and Improving Gastrointestinal Function and Process for Preparing the Same by Tri-Enzyme Hydrolysis and Micro-Particle Milling - The invention relates to a tri-enzyme hydrolysis method for preparing an oligo-saccharide enhanced oat-based drink product useful in lowering cholesterol, triglyceride, blood sugar and improving gastrointestinal function which comprises not only oat β-glucan and but also a higher amount of isomalto-oligosacchride. In accordance with the invention, whole grains of oats are micronized to an average particle size of 100 microns prior to enzyme treatments, and a product of creamy milk-like texture is obtained without filtration so that nutrients of the whole grains of oats are retained. This invention enhances the value of oat-based processing to yield additional health-associated content and illness (such as hyperlipidaemia and hyperglycemia) prevention efficacy that are beyond the potential of oats per se.2012-02-09
20120034342METHOD FOR OBTAINING A PREPARATION OF BETA-AMYLASES FROM THE SOLUBLE FRACTIONS OF STARCH PLANTS - The present invention relates to a method for obtaining a preparation of β-amylases from the soluble fraction of starch plants, characterized in that the soluble fraction of starch plants is selected from the group consisting of the soluble fractions of wheat, pea, broad bean, horse bean, rice, barley, rye, buckwheat, potato and sweet potato, and preferably of wheat and barley, a clarification of said soluble fractions is carried out in such a way as to remove therefrom the insoluble substances and the colloids and, optionally, an ultrafiltration of said clarified soluble fractions is carried out in such a way as to obtain an ultrafiltration retentate containing the concentrated β-amylase and an ultrafiltration permeate, said ultrafiltration retentate containing the concentrated β-amylase is diafiltered and the resulting β-amylase is recovered.2012-02-09
20120034343PREVENTION OF EXTRACT DARKENING AND MALODOR FORMATION DURING SOLUBILIZATION OF PLANT CELL WALL MATERIAL - The present invention relates to methods for reducing color and/or unpleasant taste and/or malodor development in a composition comprising at plant material, such a ceral bran, in particular during solubilization processes of the plant material. The invention further relates to optimised methods of solubilization, wherein color and/or unpleasant taste and/or malodor development is controlled. Solubilised plant material, kit of parts, the use of such solubilised plant material, e.g. in food products or bioethanol are also encompassed by the present invention.2012-02-09
20120034344BIOREACTORS COMPRISING FUNGAL STRAINS - Disclosed herein are compositions comprising an isolated cellulose degrading fungus. Also disclosed are culture compositions and bioreactor compositions comprising the cellulose degrading fungus. Further described herein are filtration and extraction devices comprising the cellulose degrading fungus. Still further disclosed are bioprocessing facilities for and methods for producing co-products resulting from one or more bioprocesses of the cellulose degrading fungus.2012-02-09
20120034345LOW CALORIE DAIRY PRODUCTS - The present invention pertains to fermented dairy products with reduced caloric values, in particular to low-fat, milkshakes and smoothies having reduced amounts in sugar. The dairy products of the invention comprise gelatine. They have high foaming rates and are stable over time. Further, the present invention also relates to processes and kits-of-parts for obtaining said dairy products.2012-02-09
20120034346Edible Composite Images - Edible composite images including a substrate, an underlying image, an optional lacquer barrier, an overlying image, optional varnish, and optional glaze are provided herein, wherein the overlying image obscures the underlying image at least in part and is removable by wetting or licking to reveal the underlying image. Also provided are edible flavor samples, edible pH-sensitive images, and composite images not intended for consumption.2012-02-09
20120034347BITE-SIZE CARBOHYDRATE NUTRITIONAL PRODUCTS AND METHODS FOR USING SAME - Bite-size carbohydrate-based products and methods of using same are provided. In a general embodiment, the present disclosure provides a bite-size carbohydrate-based product comprises a carbohydrate source comprising a glucogenic:fructogenic carbohydrate ratio ranging between about 1.5 to about 2.5 with at least 60% of the energy content of the bite-size carbohydrate-based product coming from the carbohydrate source. Along with the carbohydrate source, the bite-size carbohydrate-based product further comprises a suitable amount of sodium. The bite-size carbohydrate-based products can be specifically designed and provided to an athlete for customized carbohydrate intake and portion control before, during and/or after exercising.2012-02-09
20120034348Pet food and method of preparation - A pet food product and method which utilizes meaty, whole, otherwise unaltered raw animal source ingredients which are coated, bonded and sealed with concentrated dried/dehydrated/and/or freeze dried vegetables, fruits, seeds, or other plant based nutrient powders, flakes, or other particle forms of dry shelf-stable vegetables or fruits. The raw animal-sourced ingredients could be the flesh or muscle meats, organ meats, or connective tissue from beef cattle, bison, elk, venison, lamb, mutton, other mammalian sources, or any form of poultry, or any fish or other marine protein ingredients. Sources could include, but would not be limited to liver, hearts, muscle meats, kidneys, tripe, spleen, lungs, and tendons, or any animal based protein source.2012-02-09
20120034349DISTINGUISHING ABUTTING FOOD PRODUCT - A method for determining the boundary between abutting food product in a food processing system uses scan data of the food product to identify a perimeter of the abutting food product. Optionally, data from scanning the food product is first tested to determine or predict if more than one article is present. A perimeter of the abutting food product is generated from the scan data, and the perimeter information is manipulated to identify or estimate the boundary between the product. For example, the boundary may be eroded until it separates into two portions. The two portions are then expanded, constrained by the original perimeter, such that a region of interest includes overlapping portion that includes the boundary. The region of interest is analyzed to locate the boundary. In another method, a parametric shape is fit to the image to identify the individual articles. In another method, a shortest line or surface separating the perimeter into two substantial portions is found.2012-02-09
20120034350Microwave Oven for Roasting Low Moisture Foods - A roasting oven includes an enclosure coupled to a source of microwave RF energy, an operable door for sealing the enclosure for RF, the operable door having a viewing aperture which prevents the escape of RF from inside the chamber. A rotating support has an axis which is perpendicular to the viewing aperture such that the progress of roasting may be viewed through the viewing aperture and into a food container placed in the rotating support. The applied power of the microwave RF source and the rotational velocity of the rotating support are selected to provide uniform or wide spectrum roasting of the food item. A roasting profile may include a roasting interval during which the microwave RF source and rotating support are both energized, and subsequently a cool-down interval where the microwave RF source is disabled and the rotating support continues to rotate.2012-02-09
20120034351CARBONATED JELLY BEVERAGE WITH INCLUSIONS - A carbonated gelatinous beverage containing inclusions and methods for making same.2012-02-09
20120034352TARTARIC SALT STABILIZER FOR WINE - The present application relates to tartaric salt stabilizers for wine, comprising carboxymethyl cellulose agglomerates which, in dry form, readily disperse in wine without formation of lumps, and methods of stabilizing wine employing the same.2012-02-09
20120034353High Pressure Homogenization In Combination With Functionalized Egg For Production Of Emulsion-Based Food Products - An emulsified food product and method of making and using are provided herein. The emulsified food product has a small oil droplet size while also providing increased viscosity in a stable emulsion having a high fat content. The method achieves the increased viscosity and small oil droplet size by use of high pressure homogenization with enzyme-modified egg with a high fat content. The emulsified food product can be used directly as a mayonnaise product or combined with further ingredients to provide other products, including mayonnaise products with lower fat content but desirable creamy mouthfeel and viscosity.2012-02-09
20120034354Food Heating System - A food heating system has a container within which the food is to be heated. The food heating system also has a heater means for heating either or both of the food present in the container or a fluid heating medium present in the container. At least part of either or both of the food present in the container or the fluid heating medium is in the liquid phase. The heater means is controlled so as to not raise the temperature of the fluid heating medium to the boiling point of the liquid present in the container. Further, the pressure within the container is increased so as to raise the boiling point of the liquid within the container. The food heating system causes the cooking period of the foodstuff to be reduced and reduces the amount of energy required to heat the foodstuff.2012-02-09
20120034355POLYESTER COMPOSITION AND BOTTLE FOR CARBONATED PASTEURIZED PRODUCTS - This invention relates to polyester compositions useful for the manufacturing containers that minimizes the effect of secondary contamination during filling. More specifically, the present invention relates to a polyester bottle for use in filling of carbonated pasteurized products comprising at least one oxygen scavenging component that limits oxygen ingress to about 1 ppm or less when measured six months after filling, and at least one passive component that limits the carbonation loss to less than about 25% when measured six months after filing. The present invention also relates to a method of using the polyester bottle to minimize the growth of secondary contaminants in a carbonated pasteurized product.2012-02-09
20120034356METHOD FOR PROLONGING THE SHELF LIFE OF AGRICULTURAL AND FOOD PRODUCTS - A method for prolonging the shelf life of agricultural and food products is provided, especially fruit and vegetables, which method comprises forcing a stream of air to flow upwardly through a treatment zone, such that it comes into contact with a stream of an aqueous salt solution having Redox potential of not less than 200 mV on a substantially horizontally aligned perforated surface, thereby forming a layer of bubbling liquid located above said surface, and delivering the treated air which exits said treatment zone into a storage room in which said agricultural or food products are placed.2012-02-09
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